CN101849993A - Chinese medicinal sustained release tablets for treating dysentery and enteritis of livestock and poultry - Google Patents

Abstract

The invention relates to Chinese medicinal sustained release tablets for treating dysentery and enteritis of livestock and poultry, which comprise the following raw materials in part by weight: 3 to 8 parts of baical skullcap root extract, 10 to 20 parts of weeping forsythia extract, 0.2 to 0.5 part of toad venom, 3 to 8 parts of extractum glycyrrhizae, 1 to 3 parts of dahurian rhododendron leaf oil, 25 to 45 parts of hydroxypropyl methylcellulose and 10 to 20 parts of corn starch. The components of the Chinese medicinal sustained release tablets are scientifically compatible according to the GMP standard of veterinary medicaments on the basis of the theories of Chinese medicaments and sustained release preparations, semiquantitative detection is performed on active ingredients in main components by utilizing the modern scientific and technological means, and the Chinese medicinal sustained release tablets are developed by adopting the modern detection means and modern pharmaceutical equipment, and have the advantages of good curative effect, no medicament residues, high content, safety and reliability. The Chinese medicinal sustained release tablets have the definite curative effect through clinical verification, and are green veterinary medicaments which have no public hazards and medicament residues.

Description

A kind of Chinese medicine slow releasing tablet for the treatment of animal dysentery, enteritis

Technical field

The invention belongs to the herbal medicine formulation art, especially a kind of Chinese medicine slow releasing tablet for the treatment of animal dysentery, enteritis.

Background technology

Respiratory system disease has become the problem that China many large-scale cultivations field and rural culture rich and influential family extremely pay close attention to; after poultry infect respiratory tract disease; the body performance descends; benefit reduces; and become the source of infection of other healthy poultry; and be to perplex numerous raisers' a difficult problem at the problem of the Drug therapy of livestock and birds respiratory disease, the main at present antibiotic therapy of using, but antibiotic drug residue has a strong impact on the healthy of people. always

At present the Chinese medicine veterinary drug of China also is in compatibility of drugs and lacks that systematic study, product forms are coarse, the low-level state of unstable product quality, and this situation is unfavorable for the sustainable development of China's poultry industry very much.Chinese medicine has that content is lower, and the drug disposition rate of release is uncontrollable, discharges the toxic and side effects of too fast easy enhancing medicine, and thing absorption difference effect is also poor.

Summary of the invention

The objective of the invention is to overcome the deficiencies in the prior art, a kind of good effect, no drug residue, content height, safe and reliable treatment animal dysentery, the Chinese medicine slow releasing tablet of enteritis are provided.

The present invention realizes that the technical scheme of purpose is as follows:

A kind of Chinese medicine slow releasing tablet for the treatment of animal dysentery, enteritis comprises following raw material and each raw materials in part by weight:

3～8 parts of Radix Scutellariae extracts: Fructus Forsythiae extract 10-20 part; Venenum Bufonis: 0.2-0.5 part; Radix Glycyrrhizae extractum 3-8 part: Oleum Rhododendri Daurici 1-3 part; Hypromellose: 25-45 part; Corn starch: 10-20 part.

And, described Radix Scutellariae extract dry product meter, content of baicalin is no less than 85.0%, Fructus Forsythiae extract dry product meter, phillyrin content is no less than 0.50%, Radix Glycyrrhizae extractum dry product meter, glycyrrhizic acid content is no less than 20.0%.

And, also comprising the filling adjuvant, the weight fraction of interpolation is 20-30 part.

And the optimum weight umber of each raw material is as follows:

5 parts of Radix Scutellariae extracts: 15 parts of Fructus Forsythiae extracts; 0.3 part of Venenum Bufonis; 5 parts of Radix Glycyrrhizae extractum: 2 parts of Oleum Rhododendri Dauricis; 35 parts of hypromelloses; 15 parts of corn starchs; Fill 25 parts of adjuvants.

And be: described filling adjuvant comprises one of dextrin, sucrose or two or more mixture.

And the step of preparation is as follows:

(1) takes by weighing Radix Scutellariae extract, Fructus Forsythiae extract, Radix Glycyrrhizae extractum, Venenum Bufonis, Oleum Rhododendri Daurici elder generation slot-in type mixer mix homogeneously by weight;

(2) hypromellose, corn starch, filling adjuvant slot-in type mixer are continued to mix with said mixture, make soft material, granulate drying;

(3) above-mentioned dried particles and magnesium stearate are gone into three-dimensional mixer and mix, tabletting, packing.

Advantage of the present invention and beneficial effect are:

1, Chinese medicine slow releasing tablet of the present invention is according to tcm theory and slow releasing preparation theory, according to veterinary drug GMP standard, the science compatibility, and the utilization modern means of science and technology are carried out half-quantitative detection to the effective ingredient of key component, adopt a kind of good effect that modern detection means and modern pharmaceutical equipment develop, no drug residue, content height, safe and reliable Chinese medicine slow releasing tablet, through the clinical verification determined curative effect, be a kind of green veterinary drug of nuisanceless no drug residue.

2, the Chinese medicine slow releasing tablet of the present invention's preparation is pure Chinese medicine preparation, avoided the teratogenesis defective that disables of chemicals, add corn starch etc. simultaneously and play the slow releasing function composition, the slow release of medicine has improved the half-life of medicine, reduces medicining times, improve the ill domestic animal compliance, make haemoconcentration steady, avoid peak valley phenomenon, help reducing the toxic and side effects of medicine, reduce the accumulated dose of medication, to realize reaching maximum drug effect with minimum dose.

3, the Chinese medicine slow releasing tablet of the present invention's preparation is short according to the birds reproductive tract, can not digest the special physiological structure of wood fibre, pass through oral administration for ill poultry, medicine slowly discharges in vivo, directly, long-acting is in the affected part, having improved bioavailability, reduced the personnel's that culture labor intensity, is the desirable Chinese medicine preparation of current treatment livestock and birds respiratory disease.

The specific embodiment

The invention will be further described below by specific embodiment, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.

Embodiment 1:

A kind of Chinese medicine slow releasing tablet for the treatment of animal dysentery, enteritis, each raw material and parts by weight thereof are respectively:

5 parts of Radix Scutellariae extracts (the dry product meter contains baicalin and is no less than 85.0%);

15 parts of Fructus Forsythiae extracts (the dry product meter contains phillyrin and is no less than 0.50%);

5 parts of Radix Glycyrrhizae extractum (the dry product meter contains glycyrrhizic acid and is no less than 20.0%);

0.3 part of Venenum Bufonis; 2 parts of Oleum Rhododendri Dauricis; 35 parts of hypromelloses;

15 parts of corn starchs; 0.5 part of magnesium stearate; 18 parts in dextrin;

4.2 parts of sucrose.

Wherein Radix Scutellariae extract, Fructus Forsythiae extract, Radix Glycyrrhizae extractum are the extract after the water steaming and decocting, and the concentration of active substance need meet the demands in the extract, in the bracket of corresponding composition back.Dextrin and sucrose are filled adjuvant and also comprise the other materials of using as adjuvant in the medicines of being everlasting, as starch, maltose, other spice and sweeting agent etc. for filling adjuvant.

Preparation method is as follows:

(1) takes by weighing Radix Scutellariae extract, Fructus Forsythiae extract, Radix Glycyrrhizae extractum, Venenum Bufonis, Oleum Rhododendri Daurici adding trough type mixing machine mix homogeneously by weight ratio;

(2) hypromellose, corn starch are continued to mix with other adjuvant slot-in type mixers and said mixture, make soft material, granulate drying;

(3) above-mentioned dried particles and magnesium stearate are gone into three-dimensional mixer and mix, tabletting, packing, the percentage by weight that wherein adds magnesium stearate is 0.5%.

Embodiment 2

Radix Scutellariae extract (the dry product meter contains baicalin and is no less than 85.0%): 8 parts:

Fructus Forsythiae extract (the dry product meter contains phillyrin and is no less than 0.50%): 20 parts;

5 parts of Radix Glycyrrhizae extractum (the dry product meter contains glycyrrhizic acid and is no less than 20.0%):

0.5 part of Venenum Bufonis; 3 parts of Oleum Rhododendri Dauricis; Hypromellose: 45 parts;

20 parts of corn starchs; Other fill 30 parts of adjuvants;

Preparation method is with embodiment 1.

Embodiment 3

3 parts of Radix Scutellariae extracts (the dry product meter contains baicalin and is no less than 85.0%):

10 parts of Fructus Forsythiae extracts (the dry product meter contains phillyrin and is no less than 0.50%);

3 parts of Radix Glycyrrhizae extractum (the dry product meter contains glycyrrhizic acid and is no less than 20.0%):

0.2 part of Venenum Bufonis; 1 part of Oleum Rhododendri Daurici; 25 parts of hypromelloses;

10 parts of corn starchs; Fill 20 parts of adjuvants.

Preparation method is with embodiment 1.

Below be the assay of above-mentioned raw materials main component:

Radix Scutellariae extract: contain baicalin (C according to high effective liquid chromatography for measuring according to " Chinese veterinary drug allusion quotation " version in 2005 ₂₁H ₁₈O ₁₁) must not be less than 4.0%.

Fructus Forsythiae extract: contain phillyrin (C according to high effective liquid chromatography for measuring according to " Chinese veterinary drug allusion quotation " version in 2005 ₄₂H ₆₂O ₁₆) must not be less than 0.075%.

Radix Glycyrrhizae extractum: contain glycyrrhizic acid (C according to high effective liquid chromatography for measuring according to " Chinese veterinary drug allusion quotation " version in 2005 ₂₉H ₃₆O ₁₅) must not be less than 1%.

The pharmacology of each raw material of the present invention is:

Radix Scutellariae extract: have heat clearing and damp drying, eliminating fire and detoxication; The cough due to lung-heat, the damp and hot effect of gastrointestinal;

Fructus Forsythiae extract: have heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; The epidemic febrile disease heating, the yellow poisoning effect of skin ulcer;

Venenum Bufonis: have laryngopharynx swelling and pain, the yellow furunculosis effect of skin ulcer;

Oleum Rhododendri Daurici: have cough-relieving, an effect of eliminating the phlegm;

Radix Glycyrrhizae extract: have expelling phlegm for arresting cough and middle emergency, detoxifcation, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong effect.Hypromellose: have effects such as emulsifying, thickening, suspending, adhesion-promoting, bonding, gelling and film forming;

Corn starch: have effects such as slow releasing agent, filler, adhesive.

Claims (6)

1. Chinese medicine slow releasing tablet for the treatment of animal dysentery, enteritis is characterized in that: comprise following raw material and each raw materials in part by weight:

3～8 parts of Radix Scutellariae extracts: Fructus Forsythiae extract 10-20 part; Venenum Bufonis: 0.2-0.5 part; Radix Glycyrrhizae extractum 3-8 part: Oleum Rhododendri Daurici 1-3 part; Hypromellose: 25-45 part; Corn starch: 10-20 part.

2. a kind of Chinese medicine slow releasing tablet for the treatment of animal dysentery, enteritis according to claim 1, it is characterized in that: described Radix Scutellariae extract dry product meter, content of baicalin is no less than 85.0%, Fructus Forsythiae extract dry product meter, phillyrin content is no less than 0.50%, Radix Glycyrrhizae extractum dry product meter, glycyrrhizic acid content is no less than 20.0%.

3. a kind of Chinese medicine slow releasing tablet for the treatment of animal dysentery, enteritis according to claim 1 is characterized in that: also comprise the filling adjuvant, the weight fraction of interpolation is 20-30 part.

4. a kind of Chinese medicine slow releasing tablet for the treatment of animal dysentery, enteritis according to claim 3, it is characterized in that: the optimum weight umber of each raw material is as follows:

5 parts of Radix Scutellariae extracts: 15 parts of Fructus Forsythiae extracts; 0.3 part of Venenum Bufonis; 5 parts of Radix Glycyrrhizae extractum: 2 parts of Oleum Rhododendri Dauricis; 35 parts of hypromelloses; 15 parts of corn starchs; Fill 25 parts of adjuvants.

5. according to claim 3 or 4 described a kind of Chinese medicine slow releasing tablet for the treatment of animal dysentery, enteritis, it is characterized in that: described filling adjuvant comprises one of dextrin, sucrose or two or more mixture.

6. a kind of Chinese medicine slow releasing tablet for the treatment of animal dysentery, enteritis according to claim 3, it is characterized in that: the step of preparation is as follows:

(1) takes by weighing Radix Scutellariae extract, Fructus Forsythiae extract, Radix Glycyrrhizae extractum, Venenum Bufonis, Oleum Rhododendri Daurici elder generation slot-in type mixer mix homogeneously by weight;

(2) hypromellose, corn starch, filling adjuvant slot-in type mixer are continued to mix with said mixture, make soft material, granulate drying;

(3) above-mentioned dried particles and magnesium stearate are gone into three-dimensional mixer and mix, tabletting, packing.