CN101842076A - Antiperspirant composition and product - Google Patents

Abstract

Antiperspirant dispersions in the form of a cream suitable for employment in a sachet, optionally fitted with a nozzle, and having improved stability at elevated temperatures to assist manufacturing, filling, transportation and storage of the resultant filled packs in tropical climates comprise an aqueous phase in an amount of from 82 to 91.5% by weight, containing a soluble astringent antiperspirant a water-immiscible phase in an amount of from 5 to 14.5% by weight, containing at least 0.5% by weight of an oil and at least 3% by weight of a wax and at least 3.5% by weight of a mixture of non-ionic emulsifiers comprising at least 1.5% by weight of a low HLB emulsifier having an HLB value of below 7 and at least 1.5% by weight of a complementary emulsifier having an HLB value such that the weight average HLB value of said mixture is at least 10. In a big nose pack, preferably made from laminate material, the sachet sidewalls are advantageously heat welded to a tubular nozzle which is closed with a screw cap.

Description

Antipers pirant compositions and product

The present invention relates to Antipers pirant compositions and comprise described compositions, particularly seal the product of the described compositions of the dispersion form in the sachet.

Summary of the invention

Perspire in the part of oxter in order for example to resist, many in the world geographic conventional practice are to apply the compositions that comprises active antiperspirant to local skin now.The effective antiperspirant of one class comprises water solublity convergence antiperspirant salts.This material can use with the solid form in anhydrous composition, or with the solution form, for example at water or have the water miscibility material, for example uses in the aqueous mixture of low weight aliphatic alcohol.Although solution can be used as it is, the optional classification that obtains the compositions of many user's preferences comprises two-phase system, and this two-phase system comprises retainer base solution and water immiscible phase.

Antipers pirant compositions can be applied by the multiple applicator part that also can be described as allotter sometimes, and the physical property of each composition of said composition is also different, and they can be distributed from this type of applicator.Therefore, physical property from via shower nozzle spraying than dilute liquid to the solid bar that raises via large aperture distributing pipe (dispensing barrel) and difference.A kind of allotter of specific type comprises the sachet of usually being made by thermoplastic, polymeric materials, particularly comprises disclosed sachet among the WO2004/112739 of Unilever and HindustanLever.The emulsion composition that is used for this sachet is open at described ' 739 open source literatures.This sachet be heat-sealed in case its inclusions before using transportation and storing process in discharge, they are more typically in ambient temperature in transportation and/or the storing process and may surpass in 50 ℃ the tropic countries and be used for antiperspirant products in addition.Sachet is extruded, and via usually discharging its inclusions in sachet edge slit or the opening torn, this point produces restriction to the physical property of the compositions of distributing.If compositions too easily flows, it will spray from sachet, even may be when making dispense aperture, so not only waste, and be that thrifty user dislikes.

Alternatively, sachet also can be equipped with tubular nozzle, so that inclusions can be discharged on the applicator surface rapidly.Tubular nozzle can make that sachet can sealing wholesomely after each the use for example with threaded cap capping easily.This point makes in this sachet (being sometimes referred to as giant (big nose) packing) be convenient to pack into wallet or the pocket, is used for the open air, and for example whilst on tour uses.The manufacture method of giant packing is included under 180-250 ℃ sachet heat is fused to tubular nozzle, makes emulsion stand heat shock, though continue a microsecond.Heat shock may cause unstability, itself shows as to be separated, and this may take place in transportation or storing process at once or subsequently.

Two-phase compositions can be called dispersion in addition at this, be introduce sachet compositions make things convenient for form be suitable for controlling the Emulsion denseness that discharges from sachet because they can prepare to provide.But, have been found that when in storage or transportation, being exposed to high temperature the aqueous antiperspirant dispersion demonstration of hydrophobic phase becomes runny tendency.This point makes them more be not suitable for, and is dirty and be easy to be repelled by the user.Equally, this compositions may be it is desirable to and the localized hyperthermia that runs in the heat-sealing sachet process can be resisted.

Those skilled in the art understand and adopt self-supporting not flow the bar stick compositions (stickcomposition) of bar form in the open source literature with the name of Henkel (or its inventor), i.e. WO2006/119981, WP2006/136330 and US2006/0029624 and required to describe in the application of priority by them.This stick compositions is different from the compositions of the present invention in this consideration because of their physical form.The bar rod has the physical characteristic different with Emulsion, this physical characteristic to small part since use with Emulsion in the remarkable different composition of component ratio, the relative scale that comprises water and oil phase, and owing to the ratio that involves compositions Zhong Shui, oil and gellant produces.For example, the maximum % that the Henkel disclosure limits water clearly is lower than 50%, and most of embodiment uses 22.9 to 28.9%, and the water of considering among the present invention is remarkable higher ratio.Therefore, those skilled in the art's disclosure that can not will be referred to the bar stick compositions is migrated and is the solution in the emulsion composition problem of this explanation.

Many antiperspirant emulsions are described in the US5968490 of Helene Curtis Inc, use borate crosslink and therefore do not provide about need not the instruction of the compositions that borate crosslink exists but this compositions relates to.

The objective of the invention is to produce the hydrophobic phase dispersion in the aqueous antiperspirant salt solution, it is suitable for being incorporated in the sachet and overcomes or improve one or more above-mentioned shortcomings at least.

According to an aspect of the present invention, provide the aqueous Antipers pirant compositions of dispersion form, comprise

82 to 91.5wt% water, it comprises 5 to 30wt% solvable convergence antiperspirant salts,

5 to 14.5wt% water immiscible phase, its comprise the oil of 0.5wt% at least and at least 3wt% wax and

At least the nonionic emulsifier mixture of 3.5wt%, it comprise the HLB value of 1.5wt% at least be lower than 7 low HLB emulsifying agent and at least the HLB value of 1.5wt% make the weight average HLB value of described mixture be at least 10 complementary emulsifying agent.

At this, unless clearly mention in addition, wt% is based on the weight of whole dispersions.Emulsifying agent is considered between water and water immiscible phase at the interface, makes their weight get rid of and is calculating outside this phase weight biphase.

By select this composition of compositions with this relative quantity according to the present invention, the heat and the storage stability of this dispersion are improved, as by keeping much longer as shown in stable in the high temperature test.

Aspect second of the present invention, sachet is provided, it is chosen wantonly and further is connected to tubular nozzle, comprises the dispersion according to first aspect, and described sachet is particularly suitable for selling and/or resist the heat shock of making during filling sachet the tropical climate.

The 3rd aspect of the present invention comprises the method for compositions of manufacturing according to first aspect.

The 4th aspect comprises the manufacturing according to the product of second aspect.

It is optional from according to the compositions according to first aspect in the filling sachet of second aspect that the 5th aspect comprises that the part applies.

Detailed Description Of The Invention comprises preferred embodiment

The present invention relates to comprise the dispersion of water, water immiscible phase and emulsifier combination, select the composition of combination make dispersions obtained at least at high temperature, for example relatively stable under the temperature that exists among the tropical climate, and preferably resist during dispersion manufacturing and filling sachet and/or giant packing the thermal history that dispersion may experience alternatively or in addition.

The character of in carrying out the present invention's selection, having paid close attention to that factor is an emulsifier mixture.For example, it is desirable to not only consider the gross weight of emulsifying agent, and consider two components of mixture in addition, the independent weight of promptly low HLB emulsifying agent and complementary emulsifying agent.Two kinds of emulsifying agents all exist with such amount, to allow to make the dispersion with improved stability.The gross weight of the emulsifying agent that exists is desirably at least 3.5% and be in particular at least 4%.Usually, the gross weight of emulsifying agent is not higher than 8%, and in many ideal dispersions at the most 7% and particularly at the most 6%.Preferred range be dispersion 4 to 5.5wt%.Two kinds low and complementary emulsifying agent are preferably with at least 0.5: 1 and often at least 0.7: 1 weight ratio exists.Described weight ratio is not higher than 1.25: 1 usually, is not higher than 1.1: 1 in many cases.The described weight ratio of use at least 0.75: 1 has obtained excellent result, comprises that wherein said weight ratio is many dispersions of at least 0.8: 1.In many valuable dispersions, described weight ratio advantageously is 1: 1 at the most.

It is desirable to low HLB emulsifying agent with 1.5wt% at least, preferred 1.75wt% at least and the particularly amount of 2wt% existence at least.Usually, the amount of low HLB emulsifying agent is 4wt% at the most and preferred 3wt% at the most.Particularly preferred scope is 2 to 2.5wt%.Low HLB emulsifying agent has 2 to 7 HLB value usually, and many preferred low HLB emulsifying agents have the HLB value above 3.Expediently, fit closely low HLB emulsifying agent can be at the most 6, and for example 4 to 6 HLB value obtains.Although the description of writing relates to single low HLB emulsifying agent, will be appreciated that the mixture that can use weight average HLB value to meet the low HLB emulsifying agent of above-mentioned restriction.

The emulsifying agent that complementary emulsifying agent can be considered to have high HLB value, or emulsifier mixture.Usually, complementary emulsifying agent has at least 12, and advantageously at least 14,19.5 HLB value at the most for example.In some preferred embodiments, complementary emulsifying agent is the mixture of at least two kinds of emulsifying agents, and wherein a kind of have a high HLB value of 14 to 17.Equally, the emulsifier mixture that constitutes complementary emulsifying agent can comprise the emulsifying agent that for example has 17 to 19.5 higher HLB value.Advantageously use the complementary emulsifying agent that comprises high HLB emulsifying agent and Geng Gao HLB emulsifying agent.The weight ratio of this height and higher HLB emulsifying agent is preferably at least 1: 1 and be desirably 2: 1 at the most.Most suitable scope is 1.2: 1 to 1.7: 1.

Whole ratios of complementary emulsifying agent are desirably at least 2wt% and are preferably 2.2wt% at least in the dispersion.Its whole ratios are no more than the 5wt% of dispersion usually, often are 4wt% at the most, and are 3wt% at the most in many valuable embodiments.

It is desirable to especially to select to comprise contain at least 12 carbon atoms, often is the emulsifying agent of the polyalkylene oxide derivative, particularly polyethylene oxide derivant of the alkyl acid of 16 to 20 carbon atoms or alcohol.The HLB value of this emulsifying agent significantly changes with respect to the chain length of ethylene oxide unit number and moieties.Low HLB emulsifying agent often comprises 4 at the most, and preferred 2 or 3 ethylene oxide units, and for high HLB emulsifying agent, the ethylene oxide unit number often is at least 10 are about 30 unit at the most in many cases.For the emulsifying agent with higher HLB value, the poly(ethylene oxide) unit number is tended to the number of high HLB emulsifying agent overlapping, depends on hydrophobic part, begins and extend to about at the most 150 or 200 unit from about 25.Preferably use i with combining form) contain 2 or 3 cetyls or the unitary polyethylene oxide alkyl ethers of stearyl alcohol, the mixture that ii) contains 15 to 25 cetyls or the unitary polyethylene oxide alkyl ethers of stearyl alcohol and iii) contain 70 to 150 Palmic acids or the unitary poly(ethylene oxide) Arrcostab of stearic acid is as i) low HLB emulsifying agent, the representative emulsifying agent of ii) high HLB emulsifying agent and iii) higher HLB emulsifying agent.

Select the mixture of low and complementary emulsifying agent, producing at least 10, preferred at least 10.5 and at least 11 weight average HLB value particularly.Average HLB value in the described mixture is generally at the most 13, in the dispersion of many reality at the most 12.5 and particularly at the most 12.

The important component of dispersion Emulsion be can the hydrophobic phase of thickening solid.In the present invention, it is desirable to use wax and particularly fusing point to be at least 55 ℃ a kind of wax or the mixture of wax.Advantageously, selecting fusing point to be 90 ℃ at the most, is 80 ℃ wax at the most in many cases.In some highly ideal embodiments, wax has and is not higher than 70 ℃ fusing point.In the middle of the classification of the wax that satisfies above standard, preferred wax is for preferably comprising the linear aliphatic alcohol of at least 14 carbon atoms.Preferred linear aliphatic alcohol comprises 16 to 24 carbon atoms, and particularly preferred alcohol is stearyl alcohol, cetyl alcohol or this mixture of two kinds, and this mixture is often sold as 16/stearyl alcohol (cetearyl alcohol).Will be appreciated that described alcohol often comprises fraction and contains than described alcohol and Duo or other alcohol of few 2 or 4 carbon atoms.Therefore, for example, commercially available stearyl alcohol often comprises and amounts to the pure and mild docosyl alcohol of cetyl alcohol, eicosyl of 5wt% at the most.

Wax amount in the dispersion is generally 3wt% at least, often is 3.5wt% at least, and has obtained good result when having the wax of 4wt% at least.Usually and non-essential is the wax content that surpasses 7wt%, in fact under wax content is no more than the situation of 6wt%, obtained excellent result.The preferable range of wax content is 4 to 5.5wt%.At the sale or the memory period of compositions, the existence of wax causes dispersive hydrophobic (immiscible with water) to form solid particle in ambient temperature usually, although when dispersion at high temperature forms, this is the drop form mutually.The particle mean size of dispersion is subjected to the control of dispersion maker, depends in part at least to mix the intensity that said composition produces drop.In many embodiments, average particle size is lower than 25 μ m, for example greater than 1 μ m, and for example is 3 to 10 μ m.

The present invention can be in the presence of not having borate crosslink (for example borate crosslink of describing among the US5968490) the production emulsion formulations.

Another composition of dispersion is oil or oil mixture, usually with at least 1 or sometimes at least the amount of 1.25wt% exist.The gross weight of dispersion medium oil often is not higher than 6%, is not higher than 4% in many ideal embodiments.Utilize 1.3 to 3wt% oil content to obtain excellent result.

Be included in 20 ℃, one standard atmosphere at this term oil and depress the immiscible material of any and water into liquid.Therefore, can comprise one or more aromatic oil, silicone oil and or ether oil at these one or more oil.Advantageously, have for introduction into the selected silicone oil in the dispersion of the present invention and ether oil and surpass 100 ℃ boiling point.In the middle of admissible silicone oil, preferably use so-called volatile silicone oils, its most convenient ground is cyclohexyl methyl siloxanes and the preferred silicone oil that on average contains at least 4.75 silicon atoms, D5 (encircling penta dimethyl siloxane) for example, choose wantonly and contain small part D4 and/or D6, or encircle four (D4) or six dimethyl siloxanes (D6) chemical compound accordingly.Alternatively, all or part ring-type silicone oil can be substituted by volatility acyclic silicone oil or the blend similar to the cyclohexyl methyl silicone oil.Volatile silicone oils, for example the part by weight of volatility cyclohexyl methyl silicone oil in dispersion often is 0.2 to 0.8wt%, for example 0.35 to 0.55wt%.

Volatile silicone oils or its part can be substituted by so-called non-volatile silicone oil, and described non-volatile silicone oil is generally the oil that wherein a part of methyl substituents has been replaced by the residue of phenyl, diphenyl-ethyl or αJia Jibenyixi dimer.Ethereal oil often is chosen as 2: 3 to 1: 6 to the ratio of nonvolatile oil (comprising any non-volatile silicone oil) and is 1: 2 to 1: 4 in many ideal embodiments in the dispersion.

At this ether oil advantageously derived from polypropylene glycol with particularly have an aliphatic monohydric alcohol.Preferred polytrimethylene partly contains 10 to 20 unit.Very ideally, monohydric alcohol partly contains 12 to 20 or 14 to 20 carbon, and advantageously is linear, for example octadecanol or hexadecanol.The part by weight of ether oil is desirably at least 0.5% and often at the most 2% in the dispersion.

Optional, the water immiscible phase can comprise silicone elastomer, and particularly can be non-emulsifying elastomer, and described silicone elastomer is represented crosslinked polysiloxane.Suitably, crosslinked silicone elastomer can be formed by the hydrosilylation of vinylsiloxane fluid owing to hydrogen siloxane.More preferably, non-emulsifying silicone elastomer is the Dimethicone/Vinyl Dimethicone cross linked polymer.Elastomeric amount is preferably 0.025% to 0.1% of dispersion when existing.With the water immiscible phase is that benchmark is represented, elastomer often exists with 1 to 3wt% ratio of this phase.Easily, when being dispersed in the silicone oil, in the time of for example in the volatile silicone oils, can introduce elastomer.

The part by weight of water immiscible phase is generally 5 to 14.5% of dispersion in the dispersion of the present invention, and is at least 6% in many ideal prescriptions.In preferred prescription, the part by weight of described phase be dispersion at the most 11% and particularly dispersion at the most 9%.

The part by weight of water is generally 82 to 91.5% of dispersion in the dispersion of the present invention, and is at least 85% in many ideal prescriptions.In preferred prescription, the part by weight of described phase is at the most 90% of a dispersion.

Retainer base often is selected from the convergence active salt as used herein, particularly including aluminum salt, zirconates and blended aluminum-zirconium salt, includes inorganic salt and organic salt and complex for each.Preferred convergence salt comprises aluminum halide, zirconium halide and halogenation aluminum-zirconium, and hydroxyhalide (halohydrate) salt, for example hydroxychloride (chlorohydrate).Many preferred antiperspirant convergence salt are polymeric aluminum chloride (aluminium chlorohydrate) and/or zirconium, optional complexation.

Preferred aluminum salt comprises that general formula is Al ₂(OH) _xQ _y.wH ₂The halogenation hydroxy Al of O, wherein Q represents chlorine, bromine or iodine, and x is 2 to 5, and x+y=6, x and y are integer or non-integer, and w represents the variable of hydration, can be zero.Activatory polymeric aluminum chloride, those that describe among EP-A-6739 people such as () Unilever NV for example can be dissolved in the aqueous phase of this dispersion.

The zirconates that can use ideally in Antipers pirant compositions is represented by following empirical formula: ZrO (OH) _2n-nzB _z.wH ₂O, wherein z is 0.9 to 2.0 integer or non-integer, and n is the quantivalence of B, and 2n-nZ is at least 0, and B is selected from the halogen root, comprises the chlorine root, the sulfamic acid root, sulfate radical and composition thereof, w are represented the variable of hydration, can be zero.In preferred zirconates, B represents the chlorine root, and z is 1.5 to 1.87.In practice, do not use this zirconates usually separately, but as a component of blended aluminum and zirconio antiperspirant, al composition is selected according to the above-mentioned formula of hydroxyhalide (halohydrates) usually.Ideal especially salt comprises blended polymeric aluminum chloride-zirconium, and optional is activatory.

The above-mentioned formula that will be appreciated that aluminum, zirconium and aluminum-zirconium salt is experimental, and comprises the water of coordination with various amounts and/or chemical compound and polymeric material and the mixture and the complex of bound water.Especially, the zirconium hydroxy salt often represents to have the salt of various amount oh groups.

Antiperspirant complex based on above-mentioned convergence aluminum, zirconium and aluminum-zirconium salt can be used for the present invention ideally.Preferably, halogenation hydroxy Al and/or zirconyl hydroxychloride material are complexations.Complex often uses carboxylic acid or carboxylate group, and aminoacid advantageously.The amino acid whose example that is fit to comprises dl-tryptophan, dl-beta-phenyl aniline, dl-valine, dl-methionine and β-aniline, and preferably satisfies formula CH ₃(NH ₂) CO ₂The glycine of H.

Highly it is desirable to use halogenation hydroxy Al and zirconyl hydroxychloride the complex of the combination of glycine for example, for example those disclosed among US-A3792068 people such as () Luedders in some embodiments together with aminoacid.Some of those Al/Zr complex is commonly called ZAG in the literature.The ZAG active matter contains aluminum, zirconium and chlorine root usually, and the aminoacid of variable, particularly glycine, and wherein the Al/Zr ratio is 2 to 10, and particularly 2 to 6, (Al-Zr)/ratio of Cl is 2.1 to 0.9.The active matter of this preferred type can be available from Giulini, Summit and Reheis.

Some prescriptions can contain by disclosed method production among the USP 5486347 people such as () Callaghan, are dissolved in the activation ZAG complex of dispersion water subsequently.

The mol ratio that restrains the metal pair chlorine in aluminum or the aluminum-zirconium salt as used herein often is chosen as 0.9: 1 to 1.5: 1.

The part by weight of antiperspirant salts often is 10wt% at least in the compositions, is 25wt% at the most in many cases.The concentration of aqueous phase antiperspirant salts often is not more than the 25%w/w of water, is in particular the 22%w/w at the most of water.Its concentration is generally the 12%w/w at least of water, advantageously is the 15%w/w at least of water.

The part by weight of water is at least 52% in the compositions, is the difference between the maximum 30% of the minima 82% of water and antiperspirant salts.In practice, the ratio of water is generally the 65wt% of 60wt% at least and the particularly compositions of compositions.In many Ideal Match things, the ratio of water is not more than 80wt%, and in various preferred compositions, selection percentage be whole compositionss 70 to 76wt%.

In many suitable emulsion compositions according to the present invention, water is chosen as at least 10: 1 to the dispersing hydrophobic weight ratio mutually that contains wax and oil continuously, often is at least 12: 1 to 15: 1.

By the composition and the part by weight thereof of suitable selection dispersion, can production viscosity be the Emulsion of 30000mPa.s (centipoise) to 150000mPa.s, it will be suitable for being packaged in sachet and the giant packing.It is desirable to the ratio of balance wax and oil especially, the ratio of water and water immiscible phase, and the gross weight of the ratio of high emulsifying agent and complementary emulsifying agent and emulsifying agent are 80000 and/or the Emulsion of 120000mPa.s at the most to obtain viscosity.At this, the viscosity number of quoting is at 25 ℃ of use Brookfield viscometers and uses those that measure with the associated rotor of 6rpm rotation.

Dispersion of the present invention can contain ion salt by being used for making, and for example restrains any known method preparation of the aqueous dispersion of antiperspirant salts.

A kind of effective common method is included in step I) in a still blended emulsifier and wax, follow agitating heating gained mixture up to wax fusion, often reach at least 80 ℃, for example 95 to 100 ℃ temperature.Thereafter, at step I i) in, follow and stir any oil and any silicone elastomer of introducing except that aromatic oil, to keep mix flow.In second container, step I ii) in, with step I) or ii) side by side or sequentially, follow any granule of the suspended substance that being stirred in suspends in a part of water is used for dispersion.Step I v) in, its can with step I) or ii) carry out simultaneously, or in step I) or ii) before or after carry out, the remaining water except that the water that convergence exists in the antiperspirant salt solution of in another container, packing into, if any, introduce lentamente from step I suspended substance ii), the gained water is heated to above 70 ℃ for example 75 to 80 ℃.Step v) in, for example follow high energy mix to introduce step I i via recirculation circuit) product, the gained mixture is homogenized.The gained mixture of step in vi) followed stir rather than under the intimate mixing condition, being no more than about 1 ℃ speed with per minute slowly cools off, 60 ℃ have been reached up to mixture, this moment preferably individually, preferably under the intimate mixing condition, during introducing each material or afterwards soon step introduce in vii) aromatic oil and step viii) in (can before step vii) introducing restrain aqueous antiperspirant-salt solution.Thereafter, at step I x) in, be no more than 1 ℃ the speed cooling dispersion that homogenizes with per minute equally, reached 40 to 45 ℃ up to it.In practice, under this temperature of being everlasting dispersion is filled in the selected allotter, or more desirably, can allows dispersion further is cooled to ambient temperature, described allotter is generally sachet or giant packing.

The allotter of selecting for Emulsion dispersion of the present invention is sachet easily, is made by the multilayer layer tabletting of for example 2 to 4 layers usually.In some very ideal embodiments, sachet is equipped with tubular nozzle and forms the giant packing.In giant packing, nozzle generally includes from the outward extending external screw-thread neck of Unitarily molded shoulder that combines together with a limit of sachet.In order to distribute, nozzle is equipped with nut.Tubular nozzle can self be used for the sachet inclusions is discharged on the suitable applicator surface.If desired, nozzle can be connected to the applicator with inner duct, and the end of described inner duct on applicator surface is open, is communicated with the sachet fluid via tubular nozzle at the other end.

Some sachets are by comprising three layers, the laminated material manufacturing of for example outside polyester film, plating polyester film or paper tinsel and low density polyethylene (LDPE) (preferred linear) internal membrane.Suitable example comprises that reverse printed is bonded to 12 microns polyester films of 12 microns plating polyester films, bonding 30 microns linear low density polyethylene (LLDPE) film on the another side of described plating polyester film.All layers can be by means of conventional extruding layer compression technology with for example 15 microns low density polyethylene (LDPE) (LDPE) bonding.

In some embodiments, sachet four is pressed material manufacture layer by layer by what comprise outside polyester film, aluminium foil or plating polyester film, polyester film and inner LLDPE film.Suitable example comprises that reverse printed is bonded to 12 microns polyester films of 9 micron aluminum foils, 12 microns polyester films of bonding on the another side of described aluminium foil, and this is bonded to 100 microns LLDPE films this polyester film on another side.The known conventional solvent-based adhesive of polyester laminate that is applicable to of each layer usefulness bonds together.

In the giant packing, Unitarily molded tubular nozzle and shoulder are made by HDPE (high density polyethylene (HDPE)) easily, and the capping of tubular nozzle is made by PP (polypropylene) usually.

For safe and reliable distribution, the giant packing is often used auxiliary wrapper.Skin is pressed material piece layer by layer by 2 easily, and for example outside polyester film and inner LLDPE film are made, and for example 12 microns polyester films are oppositely suppressed and are bonded on 25 microns LLDPE films.Each film bonds together with the known conventional solvent-based adhesive of polyester laminate that is applicable to.

Sachet is generally rectangle or square, can be with the conventional method manufacturing, for example by along the folding single sheet material in sheet material middle part, make two edges of this sheet material be adjacent to and along from the middle part to proximate edge, with two the relative side thermal weldings or the sealing of sachet.Alternatively, sheet material that can two similar sizes placed side by side, and along three side thermal weldings or sealing.

Sachet can be filled by opening unsealing edge formation opening in a usual manner, for example on two relative sealing the margins, exert pressure relatively, or separate two sheet materials, and inject or introduce the dispersion of the present invention of predetermined close via opening by two sheet materials being applied outside suction.Adjacent openings compressed together and sealing then with sheet material.In order to make the giant sachet, replace the 4th side of sealing, the tubular nozzle orientation that will integrate with the applicator vault makes its opening in the 4th open side, and is heat-welded to laminated material.

Although the size of sachet is decided in its sole discretion with manufacturer, usually definite sachet is of a size of and holds 3 to 20ml dispersion.For simple sachet, this sachet holds 3 usually to 10ml, for example 5ml.This volume can be easily by determining that the sachet wall is of a size of and for example has 15 to 40cm, often 25 to 30cm total edge length obtains.When sachet formed giant allotter a part of, often determining that sachet is of a size of held 10 to 20ml, and for example 10 to 14ml.The edge length of often selecting this sachet is 25 to 55cm, and for example 30 to 40cm.

Although described sachet according to rectangle or square sachet, but will be appreciated that this method can be suitable for other shape, triangle for example, what it can the yes or no rule, and its side can be straight or crooked (except opening, it is advantageously straight).

Advantageously, by to select emulsifying agent and wax and any oil according to amount of the present invention and weight ratio, naturally also by considering the ratio separately of water and water immiscible phase, the dispersions obtained satisfied simultaneously standard that can easily distribute and show high-temperature stability from sachet, this stability is better than not according to optional prescription of the present invention provablely.

Dispersion of the present invention is easy in a usual manner to distribute from sachet, also promptly for example opens sachet by cutting off along an edge, if or sachet comprise a point of weakness at its edge, then tear at this some place.Apply from giant packing and to comprise from tubular nozzle easily and remove capping.Being assigned on the applicator surface dispersion most convenient, can advantageously comprising vault for the oxter, perhaps very often is to be assigned on the finger.On the local then paint skin surface of dispersion, the applicator surface that mildly rubs on the skin of being everlasting is suitably to apply dispersion equably.The weight of the dispersion that applies is decided in its sole discretion with the user, is each axillary fossa 0.1 to 0.5g and advantageously is 0.3g at least for many users.

The time that applies the antiperspirant dispersion is decided in its sole discretion and controls with the user.Many users adopted one day one or twice, usually for example when their WA in morning and/or cleaning soon before the sleep or shower after antiperspirant is being applied to skin, the routine of oxter for example.Alternatively or additionally, some users applied antiperspirant soon before they wish to keep the axillary fossa dry situation.

General description the present invention will only provide specific embodiments now by way of example in more detail.

Embodiment 1 to 9 and comparative example A are to E

In these embodiment and Comparative Examples, use following composition:

The INCI name	Trade mark	Supplier
			Deionized water		??In-house?prep.
Tristerin	?Cutina?MD	??Cognis
			The PPG-15-stearyl ether	?Arlamol?E	??Uniquema/Croda
Stearyl polyoxyethylene ether-2	?Brij??72	??Uniquema/Croda

The INCI name	Trade mark	Supplier
			Stearyl polyoxyethylene ether 20	?Brij??78	??Uniquema/Croda
PEG 100 stearates	?Myrj?59	??Uniquema/Croda
			16/stearyl alcohol	?Philicol?1618	??United?Coconut??Chemicals?Inc.
Stearyl alcohol	?Lanette?18DEO	??Cognis
			Silicone elastomer 1	?DC??9040	??Dow?Corning
Titanium dioxide	?KA-100Anatase	??Whittaker
			ACH solution 2	?Floccotan?AL123	??Guilini，Reheis
Spice 3	?Parfum

Silicone elastomer ¹Form with the about 10wt% active matter solution in the cyclohexyl methyl siloxane carrier oil provides, and is mainly D5 (encircling penta dimethyl siloxane).

ACH solution ²Be the 50wt% polymeric aluminum chloride solution in the water.

Spice ³In all embodiment and Comparative Examples is identical spice.

Dispersion in embodiment and the Comparative Examples changes over branch by following conventional method manufacturing according to following form, and tests according to the following method that provides.

The general preparation method of bench scale is included in step I) in emulsifying agent is mixed in a still with wax, and follow continuous stirring heating gained mixture up to reaching 95 to 100 ℃, guarantee the fusion of one or more waxes thus.

Thereafter, at step I i) in, will silicone elastomer and any oil except that aromatic oil introduce step I) in the molten mixture that obtains, follow stirring to keep mix flow.

In second container of anchor agitator is housed, at step I i) afterwards step I follows in ii) and is stirred in a part of water with middling speed particle shape titanium dioxide.

At step I i) step I of carrying out afterwards v) in, to the excess water of packing in another container of recirculation circuit and Silverson homogenizer except that the water that exists in the ACH solution (convergence antiperspirant salt solution) be housed, slowly introduce the ii) suspension of middle preparation of step I, and the gained water is heated to about 75 to 80 ℃.

Thereafter, step v) in, follow high energy to mix and introduce step I i via recirculation circuit) product, and the gained mixture homogenized about 2 minutes.Under situation about not homogenizing, follow stirring, with near but be no more than the about 1 ℃ speed of per minute the gained homogenised mix of step in vi) slowly cooled off, reached about 61/62 ℃ temperature up to mixture, slowly introduce aromatic oil in step in vii) this moment, homogenized thereafter about 2 minutes.

, in step viii) in when dispersion reached about 50 to 59 ℃, when particularly in preferred version, reaching 52 to 56 ℃, introduced the ACH aqueous solution and mixture was homogenized about 2 minutes thereafter.Thereafter, at step I x) in, with near dispersion, reached 40 to 45 ℃ equally up to it but the speed cooling that is no more than 1 ℃ of per minute homogenizes.Making product be cooled to ambient temperature then spends the night.This temperature is suitable for filling sachet and giant packing.

Form

Embodiment/Comparative Examples	??A	??B	??C	??D	??E	Embodiment 1	Embodiment 2
								The PPG-15 stearyl ether					??4.00	??1.00	??1.00
Tristerin	??5.00	??2.50		??7.50
								Stearyl polyoxyethylene ether 2	??0.19	??0.19	??0.19	??0.19	??3.20	??2.60	??2.30
Stearyl polyoxyethylene ether 20	??1.31	??1.31	??1.31	??1.31	??1.10	??1.80	??1.60
								PEG 100 stearates				??0.75	??0.80	??1.50	??1.30
Stearyl alcohol	??3.50	??3.50		??3.50
								16/stearyl alcohol	??1.00	??1.00	??5.00	??1.00	??1.50	??4.00	??3.00
Silicone elastomer	??0.50	??0.50	??0.50	??0.50	??0.50	??0.50	??0.50
								Water	??57.30	??59.80	??61.80	??54.05	??57.70	??57.40	??59.10
??TiO 2	??0.20	??0.20	??0.20	??0.20	??0.20	??0.20	??0.20
								Spice	??1.00	??1.00	??1.00	??1.00	??1.00	??1.00	??1.00
AcH solution	??30.00	??30.00	??30.00	??30.00	??30.00	??30.00	??30.00
								Viscosity x10 6Pa.s	??141	??105	??too??low	??＞166	??91	??105	??33
Stable hour	??＜2	??＜2	??＜2	??＜3	??2.5	??＞8	??＞8.
								Embodiment	Embodiment	3	Embodiment 4	Embodiment 5	Embodiment 6	Embodiment 7	Embodiment 8	Embodiment 9
The PPG-15 stearyl ether	??1.00	??1.00		??1.00		??1.00
								Tristerin
Stearyl polyoxyethylene ether 2	??2.30	??2.30	??2.30	??2.30	??2.30	??2.30	??2.30
								Stearyl polyoxyethylene ether 20	??1.60	??1.60	??1.60	??1.50	??1.50	??1.40	??1.40

Embodiment/Comparative Examples	??A	??B	??C	??D	??E	Embodiment 1	Embodiment 2
								PEG 100 stearates	??1.30	??1.30	??1.30	??1.20	??1.20	??1.10	??1.10
Stearyl alcohol			??5.00		??5.00		??5.00
								16/stearyl alcohol	??4.00	??5.00		??5.00		??5.00
Silicone elastomer	??0.50	??0.50	??0.50	??0.50	??0.50	??0.50	??0.50
								Water	??58.10	??57.10	??58.10	??57.30	??58.30	??57.50	??58.50
??TiO 2	??0.20	??0.20	??0.20	??0.20	??0.20	??0.20	??0.20
								Spice	??1.00	??1.00	??1.00	??1.00	??1.00	??1.00	??1.00
ACH solution	??30.00	??30.00	??30.00	??30.00	??30.00	??30.00	??30.00
								Viscosity 10 6??Pa.s	??81	??91	??101	??847	??93	??105	??111
Stable hour	??＞24.	??＞24.	??＞48.	??＞24.	??＞48.	??＞24	??＞48

From this form as seen, example composition stability at high temperature significantly be better than not according to of the present invention those.

Preparation also is in after the laboratory environment temperature (near 25 ℃) 12 hours, measures the viscosity of dispersion, and the described time considers that composition viscosity takes place by the time that the preparation of any back changes.Use has lifting support and the Brookfield viscometer that is equipped with the TF rotor of 6RPM rotation carries out viscosity measurement.

Step-make the end of T shape rod (TF) rotor contact dispersion surface.Start its rotation and lifting support simultaneously, and when ending in a minute, measure viscosity.

The integrity test of high temperature dispersion.

Represent that at this it is kept perfectly or is divided into the stability of two-layer dispersion at memory period 65 ℃ of measurements, to show that dispersion is transported and whether memory period is easy to become instability under hot conditions, wherein the temperature in transportation or the storage storehouse may be above 50 ℃.The following integrity (stability) that carries out is tested:

Charge into the dispersion sample that to test and in having the baking oven of windowpane, be heated to 65 ℃ in the volumetrical medicinal flat glass bottle of 100ml.Per hour observed the dispersion bottle in first 8 hours after being placed in the baking oven, and observed, see being kept perfectly property of dispersion or begun and separate, form top oil reservoir and/or translucent bottom water layer at 24,48 and 72 hours.

Embodiment 10

In this embodiment, the rectangle sachet is of a size of 5cm * 8cm, has the sidewall of pressing material manufacture layer by layer by 3, described 3 press material to comprise outside 12 microns polyester films layer by layer, its reverse printed is bonded to 12 microns plating polyester films, and this plating polyester film is bonded to inner 30 microns linear low density polyethylene (LLDPE) film.All layers extrude laminating method by means of routine and 15 microns low density polyethylene (LDPE)s (LDPE) bond together, and along 3 edge heat-sealings, along unencapsulated open, spray into the dispersion (5ml) of the embodiment 5 of predetermined in the sachet and seal this open edge than the minor face edge.

Embodiment 11

In this embodiment, the sachet of illustrated allotter among Fig. 1 and 2 is charged into the dispersion of 12ml embodiment 7.

Fig. 1 is illustrated in the perspective view that the appropriate location has the allotter of capping, the profile of the allotter of Fig. 2 presentation graphs 1.

Has sidewall (2a, the rectangle sachet (1) that 2b) is of a size of 6cm * 9cm is pressed the material manufacturing layer by layer by four, this four presses material to comprise outside 12 microns polyester films layer by layer, its reverse printed is bonded to 9 micron aluminum foils, this aluminium foil is bonded to 12 microns polyester films, this polyester film is bonded to 100 microns LLDPE films, each layer usefulness is known be suitable for polyester laminate based on the adhesives of conventional solvent together. Along two long edges and a minor face edge bonding, remaining side receives Unitarily molded shoulder (3) and tubular nozzle (4) with laminated material. Tubular nozzle is suitable for connecting with domeshape applicator (not shown), and this applicator has central opening, and fluid can be through this central opening to the applicator outer surface. Tubular nozzle (4) is sealed by capping (5).

Form opening by the unsealing edge of opening sachet (1) and assemble filling distributor afterwards. Shoulder (3) utilizes connector (4) and the capping (5) of installing to integrate, and is consistent with the sachet orientation and be placed in the sachet opening, is heat fused to the laminated material of formation sachet wall (2a, 2b).

Then the giant distributor is sealed in the outer packaging (not shown), this outer packaging is by a slice reverse printed and be bonded to 12 microns polyester film manufacturings of 25 microns LLDPE films.

Claims (36)

1. aqueous Antipers pirant compositions, the form for dispersion comprises

82 to 91.5wt% water, this water contain 5 to 30wt% solvable convergence antiperspirant salts,

5 to 14.5wt% water immiscible phase, this water immiscible phase contain the oil of 0.5wt% at least and the wax of 3wt% at least, and

At least the nonionic emulsifier mixture of 3.5wt%, this nonionic emulsifier mixture comprise the HLB value of 1.5wt% at least be lower than 7 low HLB emulsifying agent and at least the HLB value of 1.5wt% make the weight average HLB value of described mixture be at least 10 complementary emulsifying agent.

2. according to the dispersion of claim 1, wherein the amount of low HLB emulsifying agent is 2 to 3wt%, is preferably 2 to 2.5wt%.

3. according to the dispersion of each pro-claim, wherein complementary emulsifying agent has at least 14 HLB value.

4. according to the dispersion of each pro-claim, wherein complementary emulsifying agent is an emulsifier mixture, and wherein a kind of have a HLB value of 14 to 17.

5. according to the dispersion of each pro-claim, wherein complementary emulsifying agent is an emulsifier mixture, and wherein a kind of have a HLB value of 17 to 19.5.

6. according to the dispersion of claim 4 or 5, wherein complementary emulsion comprises that weight ratio is the mixture of two kinds of emulsifying agents of 1: 1 to 2: 1, and a kind of have a high HLB value, and another kind has higher HLB value.

7. according to the dispersion of each pro-claim, wherein the amount of complementary emulsifying agent is 2 to 4wt%, is preferably 2.2 to 3wt%.

8. according to the dispersion of each pro-claim, wherein low HLB emulsifying agent and complementary emulsifying agent exist with 0.75: 1 to 1.1: 1 weight ratio.

9. according to the dispersion of each pro-claim, wherein the amount of wax is 4 to 6wt% in the water immiscible phase.

10. according to the dispersion of each pro-claim, wherein cerul originally comprises the linear aliphatic alcohol of the fusing point with at least 55 ℃ or the mixture of described alcohol.

11. according to the dispersion of claim 10, wherein aliphatic alcohol comprises the mixture of 16 to 24 carbon atoms or described alcohol.

12. according to the dispersion of claim 11, wherein aliphatic alcohol comprises the mixture of octadecanol or itself and hexadecanol.

13. according to the dispersion of each pro-claim, wherein the ratio of wax is the 6wt% at the most of compositions.

14. according to the dispersion of each pro-claim, wherein the water immiscible phase comprises one or more aromatic oil.

15. according to the dispersion of each pro-claim, wherein the water immiscible phase comprises volatile silicone oils.

16. according to the dispersion of claim 15, wherein non-volatile silicone oil comprises ring penta dimethyl siloxane.

17. according to the dispersion of each pro-claim, the ratio of its medium oil is the 4wt% at the most of compositions.

18., comprise the oil-soluble silicone elastomer according to the dispersion of each pro-claim.

19. according to the dispersion of claim 18, wherein the amount of silicone elastomer be emulsion 0.025 to 0.1wt%.

20. according to the dispersion of each pro-claim, wherein the water immiscible phase comprises that boiling point surpasses 100 ℃ aliphatic ether oil.

21. according to the dispersion of claim 20, wherein aliphatic ether oil comprises polypropylene glycol ether.

22. according to the dispersion of claim 21, wherein polypropylene glycol ether comprises the ether of the aliphatic alcohol that contains 14 to 20 carbon atoms.

23. according to claim 20,21 or 22 dispersion, wherein ether oil exists with 0.5 to 2wt% amount.

24. according to the dispersion of each pro-claim, wherein the water immiscible phase exists with 6 to 9wt% ratio of dispersion.

25. according to the dispersion of each pro-claim, wherein water exists with 85 to 90wt% ratio of dispersion.

26. according to the dispersion of each pro-claim, wherein restraining antiperspirant salts is polymeric aluminum chloride and/or zirconium, optional is complexation.

27. according to the dispersion of each pro-claim, wherein antiperspirant salts exists with 10 to 25wt% concentration of compositions.

28. according to the dispersion of each pro-claim, wherein said composition contains 65 to 80% water.

29. according to the dispersion of each pro-claim, wherein this dispersion has 30000 to 150000mPA.s viscosity.

30. according to the dispersion of each pro-claim, when measuring＞8 hours in the high temperature integrity test, it is kept perfectly.

31. according to the dispersion of claim 30, when measuring＞24 hours in the high temperature integrity test, it is kept perfectly.

32. antiperspirant products comprises the dispersion according to each pro-claim that is sealed in the sachet.

33. according to the product of claim 32, wherein sachet is by the laminated material manufacturing.

34. according to the product of claim 33, wherein laminated material comprises inner polyethylene film and outside polyester film.

35. according to the product of claim 32 or 33, wherein laminated material comprises aluminium foil or plating polyester film.

36. according to each product of claim 32 to 34, wherein sachet is equipped with tubular nozzle, this tubular nozzle is preferably capped.

Images