CN101829165B - Method for preparing alcoholic liver disease medicinal tea by using Penthorum Chinense Pursh - Google Patents
Method for preparing alcoholic liver disease medicinal tea by using Penthorum Chinense Pursh Download PDFInfo
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Abstract
The invention belongs to the field of medicines and health care products, in particular to a new method for preparing an alcoholic liver disease medicinal tea by using Penthorum Chinense Pursh. In the new preparation method, Penthorum Chinense Pursh is prepared into medicinal tea for treating alcoholic liver disease, and the medicinal tea has specific therapeutic action on alcoholic liver disease.
Description
Technical field
The invention belongs to medicine and field of health care products, be specifically related to the preparation method and the purposes in the treatment alcoholic liver disease thereof of Penthorum chinense medicinal tea.
Background technology
Penthorum chinense has another name called Herba Lysimachiae Clethroids, Herba Penthori chinensis, delicacy from mountain pearl etc., and according to records such as " Tian Bao book on Chinese herbal medicine ", herbal for Relief of Famines, Penthorum chinense has effects such as collateral dredging is invigorated blood circulation, blood stasis dispelling dehumidifying, promoting blood circulation to remove blood stasis.
According to the disclosed GANSU KELI of Chinese drug standard WS3-B-2526-97 is to be that feedstock production gets with the Penthorum chinense, and its preparation method is as follows: get Herba Lysimachiae Clethroids 1000g, chopping, decoct with water three times, each 2 hours, collecting decoction, filter, filtrate is condensed into the clear paste of relative density 1.15～1.18 (60～65 ℃), and cooling adds ethanol and makes and contain alcohol amount and reach 60%, stir, leave standstill, filter, precipitation is with 60% washing with alcohol three times, merge washing liquid and filtrate, reclaiming ethanol and being condensed into relative density is 1.30～1.32 thick paste, adds an amount of sucrose and starch, mixing, the system granule, drying is made 540g, promptly.Function cure mainly for fall enzyme, protect the liver, jaundice eliminating, spleen invigorating.Be used for chronic active hepatitis, hepatitis B, also can be used for acute viral hepatitis.
Now existing preparation with the Penthorum chinense preparation has granule, tablet, capsule, pill, syrup, oral liquid formulation.
The inventor has applied for relating to the patent of Penthorum chinense on November 6th, 2008, patent name is: the new purposes of penthorum chinense pursh extract, application number: 200810305398.4.
The preparation method of the Penthorum chinense medicinal tea of this invention is with disclosed granule, tablet, oral liquid, capsule, pill, syrup have essential difference before.The Penthorum chinense medicinal tea system of this invention adds or does not add the medicinal tea that adjuvant is made after the Penthorum chinense medical material directly is cut into segment or pulverizing, take after adding boiled water immersion or decoction, and above-mentioned other dosage forms all are the Penthorum chinense medical material to be adopted decoct with water three times, each 2 hours and get extractum, adopt the prepared of each dosage form needs to become different preparations again according to the needs of different dosage form with reclaiming the ethanol secondary concentration behind the ethanol precipitate with ethanol again.Need will granulate or the granulation after drying behind the extract dry as granule, capsule; Oral liquid also needs high temperature sterilize etc.The finished product that different preparation technologies prepares has very big difference on curative effect.The objective of the invention is Penthorum chinense is made suitable dosage form, can avoid the improper effective ingredient that causes of preparation technology to lose in a large number or degraded, can make things convenient for patient to use again, can also improve bioavailability simultaneously.And, then solved the problems referred to above fully by Penthorum chinense being made medicinal tea,
In order to further specify the reasonability that Penthorum chinense is prepared into medicinal tea, we have carried out following research work.1, we compared Penthorum chinense is prepared into different dosage form after, active constituent content difference wherein.Wherein medicinal tea is for directly increasing the water logging bubble, and then according to the disclosed extracting method preparation of Chinese drug standard WS3-B-2526-97, result of the test sees Table 1 for oral liquid and granule.
The comparison of effective ingredient in table 1 medicinal tea aqueous solution and oral liquid, the granule
| Time | Dosage form | Content (Quercetin/crude drug) |
| 0 month | Medicinal tea (aqueous solution) | 0.140 |
| 0 month | Oral liquid | 0.098 |
| 0 month | Granule | 0.082 |
Conclusion: by above result of the test as seen, in the Penthorum chinense preparation of identical crude drug amount, quercetin content is the highest in the medicinal tea, is oral liquid secondly, and minimum is granule.The highest influence that has been to avoid technologies such as long-time high temperature decocts, concentrates to it of medicinal tea active constituent content, and being higher than the reason of granule, oral liquid content is that it has reduced this link of drying and moulding, heated time is shorter than granule, so content is a little more than granule.
2, be that further checking high temperature is to the influence of Quercetin, we have investigated the influence of sterilization time to Quercetin in the oral liquid, and result of the test sees Table 2.
Table 2 sterilization time is to the influence of oral fluidity shape and quercetin content
| Sterilising conditions | Character | Quercetin content (mg/ml) | Rate of descent (%) |
| Not sterilization | Pale brown color liquid | 0.57 | ---- |
| 100 ℃ 15 minutes | Brown liquid | 0.46 | 19.3 |
| 100 ℃ 30 minutes | Brown liquid | 0.43 | 24.5 |
Conclusion: by above-mentioned result of the test as seen, sterilization time is bigger to the content influence of Quercetin in the oral liquid, and along with the prolongation of sterilization time, Quercetin continues to descend.
3, we have also compared the variation of medicine in different forms effective ingredient in long-term put procedure, and oral liquid is that power is thought the preparation of special medicine company, and granule is commercially available GANSU KELI, and result of the test sees Table 3.
The comparison of effective ingredient during table 3 granule and oral liquid long-time stability are investigated
Conclusion: as seen by above-mentioned result of the test, solid preparation (is representative with the granule) and the liquid preparation (is representative with the oral liquid) made with the Penthorum chinense medical material, in storage process, the rate of descent (5 month descend 13.2%) of Quercetin in solid preparation illustrates that well below the rate of descent in liquid preparation (descending 46.7% in 5 months) Quercetin is extremely unstable in aqueous solution.
4, as seen by above-mentioned 3 result of the tests, active ingredient Quercetin in the Penthorum chinense is extremely unstable to high temperature, long-time stability in aqueous solution are also relatively poor, therefore present disclosed employing decocts with water 3 times, each 2 hours extraction process is worth discussion, and we think and are prepared as the optimum selection that medicinal tea should be the Penthorum chinense medical material.Press the Chinese Pharmacopoeia regulation, medicinal tea is divided into 3 kinds, is respectively block medicinal tea, packed medicinal tea, decocts medicinal tea, and wherein block medicinal tea and packed medicinal tea are soaked taking, and decocts to take after medicinal tea then need decoct with water.We have investigated the influence of decocting time to Quercetin, investigate and the results are shown in Table 4.、
Table 4 soaking temperature and decocting time are to the influence of quercetin content in the medicinal liquid
Sum up: by above-mentioned test result analysis, along with the prolongation of decocting time, medicinal liquid kind quercetin content is more and more lower, decocts 2 hours and decocted 1 hour relatively, and content has descended half.Therefore we determine that the decocting time of Penthorum chinense decoction medicinal tea is each 1 hour.
5, the comparison of Penthorum chinense different dosage form pluses and minuses
Characteristics according to each dosage form compare different dosage form Penthorum chinense preparation pluses and minuses, see Table 5.
The different preparation pluses and minuses of table 5 Penthorum chinense relatively
| Dosage form | Preparation method | Stability | Bioavailability |
| Medicinal tea | Add or do not add adjuvant after cutting off or pulverizing and make block medicinal tea, packed medicinal tea, decoct medicinal tea, omitted for a long time repeatedly decoction, remove impurity and concentration step, help the reservation of active ingredient | Better | High |
| Granule | Need repeatedly decoct for a long time, remove impurity and concentration step, the loss of active ingredient is bigger | Better | High |
| Capsule, tablet | Need repeatedly decoct for a long time, remove impurity and concentration step, the loss of active ingredient is bigger | Better | Medicine has a disintegrate, dissolving, process at body, and bioavailability is lower slightly. |
| Oral liquid, syrup | Need repeatedly decoct for a long time, remove impurity and concentration step, the loss of active ingredient is bigger | Relatively poor | High |
Conclusion: no matter medicinal tea is preparation technology, stability or bioavailability, and comparing other dosage forms all has greater advantage.
Summary of the invention
Technical problem solved by the invention provides the Preparation method and use of Penthorum chinense medicinal tea.
Particularly, be the purposes in the medicine of the preparation of Penthorum chinense medicinal tea and treatment alcoholic liver disease thereof, wherein, this medicinal tea is by the preparation of following several method and get:
A: block medicinal tea can be prepared as and not contain caked sugar shape medicinal tea and contain caked sugar shape medicinal tea.Do not contain caked sugar shape medicinal tea and be pressed into block medicinal tea with Penthorum chinense medicinal material coarse powder, fragment and Folium Camelliae sinensis or suitable adhesive; Contain caked sugar shape medicinal tea and be pressed into block medicinal tea with adjuvants such as penthorum chinense pursh extract, Penthorum chinense fine powder and sucrose.
B: packed medicinal tea is drawn herbal extract after drying with Folium Camelliae sinensis, Penthorum chinense coarse powder or part Penthorum chinense medicinal material coarse powder, and the medicinal tea of the bag of packing into can be packed into and be drunk tea bag as bag tea agent.
C: decoct medicinal tea with the Penthorum chinense medical material section of being processed into, silk or coarse powder after, the medicinal tea of the bag confession decoction of packing into.Decocting method: add water boil, each 1 hour.
The inventor is by finding the investigation of alcoholic liver disease therapeutical effect the Penthorum chinense medicinal tea: the Penthorum chinense medicinal tea is to CCl
4Liver injury model and alcoholic hepatic injury model mice have therapeutical effect, can obviously reduce ALT in the mice serum, AST, also can reduce CCl simultaneously
4The loss that hepatocyte is caused with ethanol is so the Penthorum chinense medicinal tea has therapeutical effect to alcoholic liver disease.
Obviously, according to foregoing of the present invention,,, can also make modification, replacement or the change of other various ways not breaking away under the above-mentioned basic fundamental thought of the present invention prerequisite according to the ordinary skill knowledge and the customary means of this area.
The specific embodiment of form is described in further detail foregoing of the present invention again by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
The specific embodiment
Below by the Penthorum chinense medicinal tea preclinical study of the therapeutical effect of alcoholic liver disease is illustrated beneficial effect of the present invention.
1 experiment material
1.1 reagent and medicine
Carbon tetrachloride: a chemical reagent company limited is tried in Shanghai; Ethanol: Chengdu long connection chemical reagent company limited; Bifendate: Zhejiang Prov WanBang Pharmaceutical Co., Ltd; ALT/AST testing cassete: Shanghai Rongsheng Bioisystech Co., Ltd.
1.2 animal
Kunming kind healthy mice, and body weight (20 ± 2g), provide by plant of Sichuan Province's laboratory animal special commission.
1.3 method
1.3.1 be subjected to the preparation of reagent product
The preparation of Penthorum chinense medicinal tea: get Penthorum chinense 1000g, the medicinal tea aqueous solution is made in cutting, makes the thick paste of relative density 1.30～1.32 with the freeze dryer freezing and sublimation, promptly.
The preparation of Penthorum chinense oral liquid: get Penthorum chinense 1000g, decoct with water three times, each 2 hours, collecting decoction filters, and filtrate is condensed into the clear paste of relative density 1.05～1.20, cooling adds ethanol and makes and contain alcohol amount and reach 50～75%, stirs, leave standstill, filter, precipitation is with 50～75% washing with alcohol three times, merging washing liquid and filtrate, reclaiming ethanol and being condensed into relative density is 1.30～1.32 thick paste, promptly.
1.3.2 penthorum chinense pursh extract is to CCl
4The effect of inductive mouse liver injury
Mice is normally raised 2d, is divided into normal control group, CCl at random
4Model group, Penthorum chinense medicinal tea low dose group (dosage group in 8.35g crude drug/kg), the Penthorum chinense medicinal tea (16.7g crude drug/kg), Penthorum chinense medicinal tea high dose group (the 25.05g crude drug/kg), Penthorum chinense oral liquid low dose group (dosage group in 8.35g crude drug/kg), the Penthorum chinense oral liquid (16.7g crude drug/kg), Penthorum chinense oral liquid high dose group (the 25.05g crude drug/kg), 10 every group.All the other respectively organize mouse peritoneal injection 0.1%CCl except that normal group
4Peanut oil solution 10ml/kg, the normal group mice is lumbar injection isometric(al) normal saline simultaneously, administration behind the modeling 1h first.All with 0.2ml/10g (body weight) isometric(al) gastric infusion, the normal control group gives the isometric(al) distilled water to each administration group.Successive administration carried out the modeling second time after the 5th day, and method is the same.Each organizes 15h rechallenge after the art time modeling, and the 1h eye socket is got blood after the administration, separation of serum.Measure ALT, AST with the ALT/AST testing cassete.
The result: Penthorum chinense medicinal tea and the basic, normal, high dosage of Penthorum chinense oral liquid all can make mice CCl
4The level that hepatic injury Serum ALT, AST raise reduces, and with model group utmost point significant difference is arranged relatively, and wherein the effect of Penthorum chinense medicinal tea is better than the Penthorum chinense oral liquid.The results are shown in Table 6.
Table 6 Penthorum chinense medicinal tea is to the influence of mouse carbon tetrachloride hepatic injury serum transaminase
| Group | The animal number of elements | Dosage (the g crude drug/kg) | ALT(U/L) | AST(U/L) |
| The normal control group | 10 | - | 51.21±15.32 | 33.48±8.75 |
| CCl 4Model group | 10 | - | 129.13±67.22 | 269.26±55.61 |
| Penthorum chinense oral liquid low dose group | 10 | 8.35 | 87.45±49.51 | 159.44±49.21 |
| Dosage group in the Penthorum chinense oral liquid | 10 | 16.7 | 82.75±33.78 | 90.35±31.95 |
| Penthorum chinense oral liquid high dose group | 10 | 25.05 | 72.22±32.25 | 77.91±34.83 |
| Penthorum chinense medicinal tea low dose group | 10 | 8.35 | 81.12±47.45 | 147.43±45.58 |
| Dosage group in the Penthorum chinense medicinal tea | 10 | 16.7 | 75.71±34.47 | 82.14±29.98 |
| Penthorum chinense medicinal tea high dose group | 10 | 25.05 | 69.23±31.10 | 68.25±25.26 |
1.3.3 the Penthorum chinense medicinal tea is to the effect of 50% alcohol induced mice alcoholic hepatic injury
Mice is normally raised 2d, be divided into the normal control group at random, ethanol model group (50% ethanol), Penthorum chinense medicinal tea low dose group (the 8.35g crude drug/kg), dosage group in the Penthorum chinense medicinal tea (the 16.7g crude drug/kg), Penthorum chinense medicinal tea high dose group (the 25.05g crude drug/kg), Penthorum chinense oral liquid low dose group (the 8.35g crude drug/kg), dosage group in the Penthorum chinense oral liquid (the 16.7g crude drug/kg), Penthorum chinense oral liquid high dose group (the 25.05g crude drug/kg), each administration group is all irritated stomach+0.25ml50% ethanol with 0.2ml/10g (body weight), the normal control group is irritated stomach and is given the isometric(al) distilled water, ethanol model group ig0.25ml50% ethanol+0.2ml/10g (body weight) distilled water, 10d altogether.Fasting 16h weighs after the last administration, extracts the eyeball ischemia, and separation of serum is measured ALT, AST; Simultaneously, mice is put to death in the cervical vertebra dislocation, and broken immediately abdomen is got liver, and is clean with normal saline flushing, gets liver lobus sinister same area, fix with 10% formalin solution, and paraffin embedding, the pathology inspection is done in HE dyeing.
Result: normal optical spectroscopy: the section of normal control group hepatocyte has normal polygon cell shape and structure, and endochylema is abundant, its nucleolus, lobules of liver similar round; Ethanol group pathological section is seen the obvious swelling of hepatocyte, in the cell apparent number more and do not wait, fat drop not of uniform size, nucleus is partial to cell edges owing to the extruding of fat drop, lobules of liver central authorities present lamellar or spotty necrosis; Ethanol adds the Penthorum chinense oral liquid and the section of medicinal tea group sees that hepatocyte has the swelling phenomenon, fat drop is also arranged, but swelling degree and fat drop cavity degree are obviously light than ethanol group, hepatocyte fat becomes lighter, fat drop is little, the accidental central spotty necrosis of a spot of lobules of liver of also can seeing.
Electron microscopic examination is observed: in the section of normal control group, the hepatocyte kytoplasm includes abundant organelle and inclusion, and nuclear membrane is clear and regular, kernel is big, and electron density is even and obvious, and the mitochondrion shape is normal, fat-free deposition in the kytoplasm, the rough endoplasmic reticulum regularity of distribution; The section of ethanol group hepatocyte, the volume enlargement, the nucleus edge is irregular, and kernel does not show, the obvious swelling of mitochondrion, its rough endoplasmic reticulum is obviously expanded, and fracture occurs, can see volume fat drop deposition not of uniform size in the kytoplasm; Ethanol adds the Penthorum chinense oral liquid and medicinal tea group hepatocyte is regular, and entoblast is clear, has a spot of mitochondrion the swelling distortion to occur, and rough endoplasmic reticulum is not seen tangible expansion and fracture, fat drop deposition in the rare Cytoplasm.
The level that the basic, normal, high dosage of Penthorum chinense medicinal tea all can make mice alcoholic hepatic injury Serum ALT, AST raise reduces.With model group utmost point significant difference is arranged relatively.The results are shown in Table 7.
Table 7 Penthorum chinense medicinal tea is to the influence of mice 50% alcohol induced mouse liver injury serum transaminase
| Group | The animal number of elements | Dosage (the g crude drug/kg) | ALT(U/L) | AST(U/L) |
| The normal control group | 10 | - | 62.58±14.12 | 49.26±13.37 |
| The ethanol model group | 10 | - | 132.49±4474 | 205.09±45.68 |
| Penthorum chinense oral liquid low dose group | 10 | 8.35 | 99.53±45.27 | 175.55±47.19 |
| Dosage group in the Penthorum chinense oral liquid | 10 | 16.7 | 95.35±36.69 | 101.91±49.09 |
| Penthorum chinense oral liquid high dose group | 10 | 25.05 | 87.07±34.17 | 92.80±27.19 |
| Penthorum chinense medicinal tea low dose group | 10 | 8.35 | 92.19±40.24 | 159.51±46.12 |
| Dosage group in the Penthorum chinense medicinal tea | 10 | 16.7 | 83.66±33.52 | 89.28±40.23 |
| Penthorum chinense medicinal tea high dose group | 10 | 25.05 | 79.28±25.11 | 81.76±26.92 |
1.3.4 conclusion
This experimental result shows that Penthorum chinense medicinal tea and Penthorum chinense oral liquid are to CCl
4Liver injury model and alcoholic hepatic injury model mice all have protective effect, and the effect of ALT, AST in the tangible reduction mice serum is arranged, and also can reduce CCl simultaneously
4The damage that hepatocyte is caused with ethanol.From test data analyzer, the effect of Penthorum chinense medicinal tea is better than the Penthorum chinense oral liquid, and analysis is that quercetin content is higher than due to the reason of Penthorum chinense oral liquid in the Penthorum chinense medicinal tea medicinal liquid, illustrates also that thus Penthorum chinense is prepared into medicinal tea and can obtains better drug effect.
Claims (1)
1. the preparation method of a Penthorum chinense medicinal tea, it is characterized in that: get Penthorum chinense 1000g, the medicinal tea aqueous solution is made in cutting, makes the thick paste of relative density 1.30-1.32 with the freeze dryer freezing and sublimation, promptly.
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| CN102321513B (en) * | 2011-07-14 | 2015-11-25 | 泸州医学院 | Penthorum chinense pursh wine and preparation method thereof |
| CN103478345B (en) * | 2013-08-14 | 2015-06-03 | 刘珂 | Production process of penthorum chinense pursh leaf tea |
| CN103431121A (en) * | 2013-09-06 | 2013-12-11 | 张宗强 | Health-care tea |
| CN104147057A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Freeze-drying method as method of preparing high-activity penthorum chinense pursh |
| CN108478610A (en) * | 2018-06-30 | 2018-09-04 | 浙江中医药大学 | A kind of penthorum chinense pursh extract and its application |
| CN109601795A (en) * | 2019-01-11 | 2019-04-12 | 重庆师范大学 | Using penthorum chinense pursh as composition alcohol-decomposing beverage of primary raw material and preparation method thereof |
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