CN101810759A - Curbitacin-containing medicine - Google Patents
Curbitacin-containing medicine Download PDFInfo
- Publication number
- CN101810759A CN101810759A CN 201010158627 CN201010158627A CN101810759A CN 101810759 A CN101810759 A CN 101810759A CN 201010158627 CN201010158627 CN 201010158627 CN 201010158627 A CN201010158627 A CN 201010158627A CN 101810759 A CN101810759 A CN 101810759A
- Authority
- CN
- China
- Prior art keywords
- grams
- extract
- radix
- rhizoma
- hepatitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 26
- 208000006454 hepatitis Diseases 0.000 claims abstract description 17
- 239000000284 extract Substances 0.000 claims abstract description 15
- 231100000283 hepatitis Toxicity 0.000 claims abstract description 13
- 239000000203 mixture Substances 0.000 claims abstract description 13
- 238000002360 preparation method Methods 0.000 claims abstract description 7
- LNSXRXFBSDRILE-UHFFFAOYSA-N Cucurbitacin Natural products CC(=O)OC(C)(C)C=CC(=O)C(C)(O)C1C(O)CC2(C)C3CC=C4C(C)(C)C(O)C(O)CC4(C)C3(C)C(=O)CC12C LNSXRXFBSDRILE-UHFFFAOYSA-N 0.000 claims description 9
- CVKKIVYBGGDJCR-SXDZHWHFSA-N Cucurbitacin B Natural products CC(=O)OC(C)(C)C=CC(=O)[C@@](C)(O)[C@@H]1[C@@H](O)C[C@]2(C)C3=CC[C@@H]4C(C)(C)C(=O)[C@H](O)C[C@@]4(C)[C@@H]3CC(=O)[C@@]12C CVKKIVYBGGDJCR-SXDZHWHFSA-N 0.000 claims description 9
- 150000001904 cucurbitacins Chemical class 0.000 claims description 9
- PIGAXYFCLPQWOD-UHFFFAOYSA-N dihydrocucurbitacin I Natural products CC12C(=O)CC3(C)C(C(C)(O)C(=O)CCC(C)(O)C)C(O)CC3(C)C1CC=C1C2C=C(O)C(=O)C1(C)C PIGAXYFCLPQWOD-UHFFFAOYSA-N 0.000 claims description 9
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 241000222336 Ganoderma Species 0.000 claims description 4
- 239000009636 Huang Qi Substances 0.000 claims description 4
- 241000219784 Sophora Species 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 3
- 230000006837 decompression Effects 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 239000000469 ethanolic extract Substances 0.000 claims description 2
- 238000004064 recycling Methods 0.000 claims description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 230000001154 acute effect Effects 0.000 description 7
- 206010067125 Liver injury Diseases 0.000 description 6
- 208000002672 hepatitis B Diseases 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000003390 Chinese drug Substances 0.000 description 4
- 206010008909 Chronic Hepatitis Diseases 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
- 125000001202 cucurbitacin group Chemical group 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 206010019668 Hepatic fibrosis Diseases 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 231100000753 hepatic injury Toxicity 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 208000035473 Communicable disease Diseases 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- 206010019799 Hepatitis viral Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 102000003929 Transaminases Human genes 0.000 description 2
- 108090000340 Transaminases Proteins 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 231100000012 chronic liver injury Toxicity 0.000 description 2
- 208000019425 cirrhosis of liver Diseases 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 201000001862 viral hepatitis Diseases 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 208000005331 Hepatitis D Diseases 0.000 description 1
- 206010019754 Hepatitis cholestatic Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 231100000439 acute liver injury Toxicity 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 231100000838 cholestatic hepatitis Toxicity 0.000 description 1
- 230000002079 cooperative effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- SPPIIOPGDLITJE-VLQRKCJKSA-N diazanium;(2s,3s,4s,5r,6s)-6-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxylato-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-5-[(2r,3r,4s,5s,6s)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy-3,4-dihy Chemical compound N.N.O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O SPPIIOPGDLITJE-VLQRKCJKSA-N 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 230000036732 histological change Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 208000037890 multiple organ injury Diseases 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Group | Number of animals | GOT (active unit) | GPT (active unit) |
The normal control group | ??10 | ??26.12±18.51 | ??49.22±19.23 |
Model control group | ??10 | ??252.16±77.82 | ??298.96±57.83 |
Pure Chinese drug-treated group | ??10 | ??177.35±58.12 | ??239.93±56.31 |
The cucurbitacin group | ??10 | ??110.82±39.72 | ??208.52±32.82 |
The compositions group | ??10 | ??88.73±33.65 | ??108.27±46.81 |
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010101586271A CN101810759B (en) | 2010-04-27 | 2010-04-27 | Curbitacin-containing medicine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010101586271A CN101810759B (en) | 2010-04-27 | 2010-04-27 | Curbitacin-containing medicine |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101810759A true CN101810759A (en) | 2010-08-25 |
CN101810759B CN101810759B (en) | 2011-08-31 |
Family
ID=42618219
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2010101586271A Expired - Fee Related CN101810759B (en) | 2010-04-27 | 2010-04-27 | Curbitacin-containing medicine |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101810759B (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1106690A (en) * | 1994-11-19 | 1995-08-16 | 天津市第一医院 | Medicine of curing hepatitis |
CN1899492A (en) * | 2006-07-06 | 2007-01-24 | 张砚 | Synergistic medicinal composition for treating hepatitis |
-
2010
- 2010-04-27 CN CN2010101586271A patent/CN101810759B/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1106690A (en) * | 1994-11-19 | 1995-08-16 | 天津市第一医院 | Medicine of curing hepatitis |
CN1899492A (en) * | 2006-07-06 | 2007-01-24 | 张砚 | Synergistic medicinal composition for treating hepatitis |
Non-Patent Citations (3)
Title |
---|
《中国新药杂志》 19961231 李庶心等 《防治慢性肝炎药物使用现状及研究进展》 401-406 1-2 第5卷, 第6期 2 * |
《中国药店》 20021231 刘宁 《肝炎用药简析》 64 1-2 , 第9期 2 * |
《齐鲁药事》 20051231 么焕开等 《葫芦素的研究概况》 737-739 1-2 第24卷, 第12期 2 * |
Also Published As
Publication number | Publication date |
---|---|
CN101810759B (en) | 2011-08-31 |
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C06 | Publication | ||
PB01 | Publication | ||
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ASS | Succession or assignment of patent right |
Owner name: LUO DANXIAO Free format text: FORMER OWNER: ZHANG DAYU Effective date: 20110524 |
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C41 | Transfer of patent application or patent right or utility model | ||
C53 | Correction of patent of invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Luo Danxiao Inventor before: Zhang Dayu |
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COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100070 BUILDING 18, AREA 8, HEADQUARTER BASE, NO. 188, SOUTH 4TH RING ROAD WEST, FENGTAI DISTRICT, BEIJING TO: 315153 XIANGMEI JIAYUAN RESIDENTIAL QUARTER, SHIQUAN ROAD, SHIQI SUBDISTRICT, YINZHOU DISTRICT, NINGBO CITY, ZHEJIANG PROVINCE Free format text: CORRECT: INVENTOR; FROM: ZHANG DAYU TO: LUO DANXIAO |
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TA01 | Transfer of patent application right |
Effective date of registration: 20110524 Address after: 315153 Zhejiang city of Ningbo province Yinzhou District Shiqi Street Shiquan Road Xiangmei Garden Applicant after: Luo Danxiao Address before: 100070, No. 18, building eight, 188, base station, South Fourth Ring Road West, Beijing, Fengtai District Applicant before: Zhang Dayu |
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C14 | Grant of patent or utility model | ||
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Owner name: NANTONG HUAKE INTELLECTUAL PROPERTY SERVICE CO., L Free format text: FORMER OWNER: LUO DANXIAO Effective date: 20121221 |
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C41 | Transfer of patent application or patent right or utility model | ||
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Free format text: CORRECT: ADDRESS; FROM: 315153 NINGBO, ZHEJIANG PROVINCE TO: 226600 NANTONG, JIANGSU PROVINCE |
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TR01 | Transfer of patent right |
Effective date of registration: 20121221 Address after: 226600 No. 8 Yingbin Road, Chengdong Town, Haian County, Nantong, Jiangsu Patentee after: Nantong Huake Intellectual Property Service Co.,Ltd. Address before: 315153 Zhejiang city of Ningbo province Yinzhou District Shiqi Street Shiquan Road Xiangmei Garden Patentee before: Luo Danxiao |
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ASS | Succession or assignment of patent right |
Owner name: HAIAN CHANGDA TECHNOLOGY TRANSFER CENTER CO., LTD. Free format text: FORMER OWNER: NANTONG HUAKE INTELLECTUAL PROPERTY SERVICE CO., LTD. Effective date: 20140514 |
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C41 | Transfer of patent application or patent right or utility model | ||
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Effective date of registration: 20140514 Address after: 226600 No. 8 Yingbin Road, Haian County, Nantong, Jiangsu Patentee after: HAIAN CHANGZHOU UNIVERSITY TECHNOLOGY TRANSFER CENTER Co.,Ltd. Address before: 226600 No. 8 Yingbin Road, Chengdong Town, Haian County, Nantong, Jiangsu Patentee before: Nantong Huake Intellectual Property Service Co.,Ltd. |
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Effective date of registration: 20221226 Address after: 413, Floor 4, Building B, Innovation Building, Linyi Hi tech Industrial Development Zone, Shandong Province, 276000 Patentee after: Linyi High tech Zone Jinlanling Labor Service Co.,Ltd. Address before: 226600 No.8 Yingbin Road, Hai'an County, Nantong City, Jiangsu Province Patentee before: HAIAN CHANGZHOU UNIVERSITY TECHNOLOGY TRANSFER CENTER Co.,Ltd. |
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TR01 | Transfer of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110831 |
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CF01 | Termination of patent right due to non-payment of annual fee |