CN101805453A - Method for modifying surface hydrophilicity of additional room temperature vulcanizing silicone rubber - Google Patents
Method for modifying surface hydrophilicity of additional room temperature vulcanizing silicone rubber Download PDFInfo
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- CN101805453A CN101805453A CN201010139428A CN201010139428A CN101805453A CN 101805453 A CN101805453 A CN 101805453A CN 201010139428 A CN201010139428 A CN 201010139428A CN 201010139428 A CN201010139428 A CN 201010139428A CN 101805453 A CN101805453 A CN 101805453A
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Abstract
The invention relates to a method for modifying surface hydrophilicity of additional room temperature vulcanizing silicone rubber. The method adopts the additional room temperature vulcanizing silicone rubber as matrix material and adopts oxygen as treating atmosphere, the treating power is 20W-100W, and the treating time is 30s-10min. The method improves the hydrophilicity of the additional room temperature vulcanizing silicone rubber effectively, keeps the smoothness of the matrix material and reduces the absorption of protein by the matrix material, thus keeping good optical performance of the matrix material. The method has the advantages of convenient operation, short action time, high treating efficiency and the like.
Description
Technical field:
The present invention relates to a kind of method of addition type room temperature vulcanized silicone rubber modification, be specifically related to a kind of method of utilizing oxygen plasma modification surface hydrophilicity of additional room temperature vulcanizing silicone rubber.
Background technology:
Addition type room temperature vulcanized silicone rubber is meant the polysiloxane (being called for short basic glue) that contains vinyl and linking agent containing hydrogen silicone oil under the platinum catalyst effect, the elastomerics with tridimensional network that forms by addition reaction of silicon with hydrogen under room temperature.Though the addition type room temperature vulcanized silicone rubber developing history is shorter, can become very active research direction of one in silicon rubber field in self cure, excellent property, advantage such as easy to use with it.Addition type room temperature vulcanized silicone rubber in sulfidation, do not produce by product, shrinking percentage minimum, can deep layer vulcanization, thereby can be used to prepare purity height, the transparency is high, precision is high product.
Do not cause foreign body reaction behind heat-resisting, cold-resistant, nontoxic, anti-biological aging that room temperature vulcanized silicone rubber has, physiology inertia,, the implant into body tissue minimum, surrounding tissue is not caused inflammation and good advantages such as physical and mechanical properties, meet the requirement of medical macromolecular materials the tissue reaction; Aspect health care, medical science, obtain application more and more widely.Development so far, addition type room temperature vulcanized silicone rubber can roughly reduce in the application of medical treatment, medicine and health industry: keep somewhere for a long time in the intravital organ or tissue of people surrogate, short-term keep somewhere the intravital medicine equipment of people, lift face medicine equipment, medicament slow release system, external articles for use such as articles for babies etc. several aspect.
Addition type room temperature vulcanized silicone rubber has occupied considerable status at medical field, but wanting has great development, still need solve the relevant technologies problem, as the hydrophobicity of material surface, still have slight foreign body sensation behind its goods implant into body, need to adopt surface modification to solve.
Summary of the invention:
In order to solve the problem that exists in the background technology.The invention provides a kind of method of modifying surface hydrophilicity of additional room temperature vulcanizing silicone rubber, this method utilizes oxygen plasma that the surface hydrophilicity of addition type room temperature vulcanized silicone rubber is carried out modification, this method can effectively be improved the wetting ability of addition type room temperature vulcanized silicone rubber, the slipperiness that has kept body material, reduce body material to absorption of proteins, thereby kept body material good optical performance.That this method has is easy to operate, action time short, the processing efficiency advantages of higher.
The technical solution adopted in the present invention is: the method for this modifying surface hydrophilicity of additional room temperature vulcanizing silicone rubber is a body material with the addition type room temperature vulcanized silicone rubber, and oxygen is for handling atmosphere, and processing power is 20W～100W, and the treatment time is 30s～10min.
Above-mentioned addition type room temperature vulcanized silicone rubber body material directly is exposed in the oxygen gas plasma; Processing power is 100W, and the treatment time is 30s; The water contact angle of the body material after the modification is 20～50 °.
Addition type room temperature vulcanized silicone rubber after the modification is used for intraocular lens, contact lens, cornea structure reparation and the equivalent material and the artificial blood vessel of ophthalmology bio-medical material.
The invention has the beneficial effects as follows: the present invention is through the surface hydrophilicity modification of oxygen gas plasma to addition type room temperature vulcanized silicone rubber, the wetting ability of addition type room temperature vulcanized silicone rubber is improved greatly, contact angle has dropped to about 20 ° by original 110 °, simultaneously substrate material surface is not caused etching, the ability of the substrate material surface adsorbed proteins after the modification descends greatly, has improved the anti-protein contamination ability of body material.Best power and the Best Times of having selected oxygen gas plasma to handle addition type room temperature vulcanized silicone rubber of the present invention; guaranteeing under the best prerequisite of hydrophilically modified effect; body material itself is not caused tangible etching, guarantee body material good optical performance.
Description of drawings:
Fig. 1 is O
2Plasma treatment time and watt level are to the influence of surface contact angle;
Fig. 2 is O
2Cement Composite Treated by Plasma rear surface contact angle over time;
Fig. 3 is O
2Plasma treatment time is to the atomic force microscope photo of the influence of surface topography;
Fig. 4 is O
2The fluorescent microscope photo of Cement Composite Treated by Plasma rear surface bovine serum albumin (BSA-FITC) absorption.
Embodiment:
The invention will be further described below in conjunction with embodiment:
The Sylgard184 type addition type room temperature vulcanized silicone rubber of selecting for use Dow Corning Corporation to produce is cut into the sample strip of 2cm*2cm with Sylgard184 type addition type room temperature vulcanized silicone rubber, extracts with sherwood oil, and final drying is material 1 for use.
The prepared sample of addition type room temperature vulcanized silicone rubber is exposed in the oxygen gas plasma, uses 20W respectively, the power of 50W and 100W has respectively been handled 30s, and 3min and 10min test the contact angle of the sample after handling.The result confirms: find 100W, under the 30s treatment condition, it is maximum that the contact angle of sample descends, and arrives 20 °.As shown in Figure 1.
In order to keep the wetting ability on addition type room temperature vulcanized silicone rubber surface after the oxygen gas plasma modification, be kept at the material after the modification in the deionized water respectively and air in observe the trend of wetting ability along with the variation of shelf time.The result confirms: the surface hydrophilicity of the material after the modification is preserved in deionized water and was not changed in one month, and is kept at the hydrophobicity before airborne material has returned to modification.As shown in Figure 2.
The plasma gas of short period of time is handled can carry out modification to material surface, yet overlong time can cause etching to material surface, cracks.Processing power 100W is adopted in this experiment, silastic surface is carried out 30s, the O of 3min and 10min
2Low Temperature Plasma Treating, find by scanning electron microscope and atomic force microscope observation, the processing of short period of time, as the processing of 30s, can making originally, coarse material surface becomes level and smooth, when the treatment time is that 3min is during to 10min, material surface cracks, and prolongation in time, and crackle is deepened about by 5nm to about the 25nm, and the perk of crackle edge also reaches about 10nm.As shown in Figure 3.
Pass through O
2Low Temperature Plasma Treating 100W behind the 30s, observes the ability of the anti-protein adsorption in material processing front and back with the bovine serum albumin (FITC-BSA) of FITC mark.With FITC-BSA with 100 μ g/cm
2Be added drop-wise to two kinds of material surfaces before and after handling, lucifuge is hatched 1h, then material is taken out, with deionized water rinsing twice, lucifuge seasoning at room temperature at last.Observe the intensity of the green fluorescence of material surface afterwards by the fluorescence co-focusing microscope.Found that the green fluorescence intensity through the material surface after the surface modification is starkly lower than untreated material, illustrates that surface modification can effectively reduce the adsorptive capacity of bovine serum albumin at material surface, as shown in Figure 4.
According to GB/T-16886.5-2003, the vat liquor of the material 1 among the preparation embodiment 1 comes the lens epithelial cells of cultivator, observes the influence of material to the human eye cell, and the result confirms that the propagation of 1 couple of people's of material lens epithelial cells does not also make significant difference.The results are shown in Table 1.
The vitro cytotoxicity of addition type room temperature vulcanized silicone rubber (the OD value:
) table 1
Claims (7)
1. the method for a modifying surface hydrophilicity of additional room temperature vulcanizing silicone rubber, this method is body material with the addition type room temperature vulcanized silicone rubber, and oxygen is for handling atmosphere, and processing power is 20W～100W, and the treatment time is 30s～10min.
2. the method for modifying surface hydrophilicity of additional room temperature vulcanizing silicone rubber according to claim 1 is characterized in that: the addition type room temperature vulcanized silicone rubber body material directly is exposed in the oxygen gas plasma.
3. the method for modifying surface hydrophilicity of additional room temperature vulcanizing silicone rubber according to claim 1 and 2, it is characterized in that: the treatment time is 30s.
4. the method for modifying surface hydrophilicity of additional room temperature vulcanizing silicone rubber according to claim 1 and 2, it is characterized in that: processing power is 100W.
5. the method for modifying surface hydrophilicity of additional room temperature vulcanizing silicone rubber according to claim 1 and 2, it is characterized in that: processing power is 100W, the treatment time is 30s.
6. the method for modifying surface hydrophilicity of additional room temperature vulcanizing silicone rubber according to claim 1 and 2, it is characterized in that: the water contact angle of the body material after the modification is 20～50 °.
7. the addition type room temperature vulcanized silicone rubber after the method modification according to claim 1 and 2 is characterized in that: the intraocular lens, contact lens, cornea structure reparation and equivalent material and the artificial blood vessel that are used for the ophthalmology bio-medical material.
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| CN2010101394286A CN101805453B (en) | 2010-03-31 | 2010-03-31 | Method for modifying surface hydrophilicity of additional room temperature vulcanizing silicone rubber |
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| CN2010101394286A CN101805453B (en) | 2010-03-31 | 2010-03-31 | Method for modifying surface hydrophilicity of additional room temperature vulcanizing silicone rubber |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104194025A (en) * | 2014-09-30 | 2014-12-10 | 常州大学 | Preparation method of biocompatible silicone rubber |
| CN112375247A (en) * | 2020-12-02 | 2021-02-19 | 中国科学院合肥物质科学研究院 | Corneal contact lens treatment method based on amphiphilic composite gradient functional membrane |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2003068846A1 (en) * | 2002-02-18 | 2003-08-21 | Nkt Research & Innovation A/S | Methods of treating polymeric substrates |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003068846A1 (en) * | 2002-02-18 | 2003-08-21 | Nkt Research & Innovation A/S | Methods of treating polymeric substrates |
| CN1633459A (en) * | 2002-02-18 | 2005-06-29 | 南农股份公司 | Methods of treating polymeric substrates |
Non-Patent Citations (4)
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| 张一鸣等: "医用硅橡胶生物相容性改性研究进展", 《重庆医学》 * |
| 戚云霞: "加成型室温硫化硅橡胶的制备及改性", 《中国优秀博硕士学位论文数据库（硕士） 工程科技I辑》 * |
| 邹石泉: "不同等离子体改性后硅橡胶的表面润湿性变化", 《第六次全国口腔修复学学术会议论文摘要汇编》 * |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104194025A (en) * | 2014-09-30 | 2014-12-10 | 常州大学 | Preparation method of biocompatible silicone rubber |
| CN104194025B (en) * | 2014-09-30 | 2017-04-19 | 常州大学 | Preparation method of biocompatible silicone rubber |
| CN112375247A (en) * | 2020-12-02 | 2021-02-19 | 中国科学院合肥物质科学研究院 | Corneal contact lens treatment method based on amphiphilic composite gradient functional membrane |
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| CN101805453B (en) | 2012-11-07 |
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