CN101803933A - Liver fibrosis detection device - Google Patents
Liver fibrosis detection device Download PDFInfo
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- CN101803933A CN101803933A CN200910105446A CN200910105446A CN101803933A CN 101803933 A CN101803933 A CN 101803933A CN 200910105446 A CN200910105446 A CN 200910105446A CN 200910105446 A CN200910105446 A CN 200910105446A CN 101803933 A CN101803933 A CN 101803933A
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- probe
- liver
- ultrasonic probe
- tracking system
- computer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/42—Details of probe positioning or probe attachment to the patient
- A61B8/4245—Details of probe positioning or probe attachment to the patient involving determining the position of the probe, e.g. with respect to an external reference frame or to the patient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/485—Diagnostic techniques involving measuring strain or elastic properties
Abstract
The invention provides a liver fibrosis detection device used for detecting the fibrosis degree of the liver in the body. The device comprises an ultrasonic probe, a probe tracking system, a signal processing module and a computer, wherein the probe tracking system is electrically connected with the ultrasonic probe; the signal processing module is electrically connected with the ultrasonic probe; the computer is connected with the probe tracking system and the signal processing module and provided with system software; the ultrasonic probe is used for emitting low-frequency vibration into the body, and meanwhile, the transmission of shear waves formed by the vibration in the liver tissue is detected by utilizing ultrasound; the probe tracking system is used for building a space three-dimensional coordinates system and detecting the position and the angle of the ultrasonic probe relative to the liver tissue in real time; the signal processing module is used for acquiring and processing echo electric signals acquired by the probe; and the real-time quantitative information of the liver fibrosis of corresponding coordinates and angles is obtained through the processing and the analysis of the computer. The invention solves the problems that the detection is invasive, the expense is high, and the liver tissue hardness cannot be evaluated from various directions and angles in the prior art.
Description
Technical field
The present invention relates to a kind of medical apparatus and instruments, relate in particular to a kind of liver fibrosis detection device.
Background technology
People's hepatic fibrosis is especially common pathologic basis of chronic hepatopathy of many hepatic disease, and the pathological changes weight changes with fibrosis is different.Early diagnosis and quantize degree of hepatic fibrosis for timely intervention with reverse its development and have great importance.Liver biopsy is the golden standard of liver fibrosis diagnosis.But liver biopsy has wound, and because the inhomogeneities that fibrosis distributes may cause sampling error, has accuracy and reproducibility problems, and it is also higher to remove this inspection fee.
When fibrosis appearred in hepatic tissue, the acoustic interface impedance contrast of tissue or sound scattering index variation were also not obvious, so simple ultra sonic imaging can't play a role.The traditional medicine image mode that comprises nuclear magnetic resonance (MRI), computed tomography (CT) etc. in addition all can not directly provide fibrosis information.
Because hepatic fibrosis directly causes the elasticity of liver to change,, can obtain hepatic fibrosis information thus so the elasticity that can quantize to detect liver organization by ultrasonic elastograph imaging is hardness number.But the mode of present elastogram can not obtain from the hardness information of each orientation and angle liver organization, if the cirrhosis zone is less or the position is more inclined to one side, causes the situation of failing to pinpoint a disease in diagnosis easily.
Summary of the invention
The present invention will solve its technical problem and be to provide a kind of liver fibrosis detection device based on horseley-Clarke technique, to solve that prior art has wound, expense is high and can not be from the problem of each orientation and angle assessment liver organization hardness.
The technical solution adopted for the present invention to solve the technical problems is: a kind of liver fibrosis detection device, fibrosis in order to liver in the detection bodies, it is characterized in that: described liver fibrosis detection device comprises ultrasonic probe, the probe tracking system that is electrically connected with described ultrasonic probe, the signal processing module that is electrically connected with described ultrasonic probe, and with described probe tracking system and signal processing module and computer that have systems soft ware, described ultrasonic probe is launched low-frequency vibration in body, utilize the formed shearing wave of the described vibration of supersonic sounding in liver organization, to propagate simultaneously, described probe tracking system constructing 3 d space coordinate is, and detect position and the angle of ultrasonic probe in real time with respect to hepatic tissue, described signal processing module collection is also handled the echo signal of telecommunication that probe obtains, and obtains the real-time quantitative information of hepatic fibrosis under corresponding coordinate and the angle by the Computer Processing analysis.
Described probe tracking system comprises telltale mark, detector, and the interface module that is electrically connected with detector; Described telltale mark is fixed in patient's body surface at least three place's diverse locations to make up three dimensional space coordinate system, the described ultrasonic probe of described detector real-time detection is with respect to the space coordinates and the emission angle of space coordinates, data signal is imported the computer that survey plan software is housed into by described interface module, and the described COMPUTER CALCULATION that survey plan software is housed goes out angle and the path that ultrasound wave propagates and demonstrates in liver.
Comprise the low-frequency vibration generator in the described ultrasonic probe, ultrasonic transducer and the positioner that can supply the probe tracking system keeps track, described low-frequency vibration generator is launched low-frequency vibration in body, described ultrasonic transducer is launched ultrasound wave in body simultaneously, survey the formed shearing wave of low-frequency vibration by echo-signal and in liver organization, propagate, and coherent signal is passed to described signal processing module.
Described signal processing module can be gathered the echo-signal of ultrasonic probe and handle, and the signal after will handling simultaneously imports computer into.
Described computer comprises at least organizes hardness measuring and calculating module, probe orientation tracking module and digital simulation display module; The described hardness measuring and calculating module of organizing is analyzed and is calculated treated ultrasound echo signal, derive the hardness parameter of liver organization, described probe orientation tracking module becomes real-time coordinate and data with the conversion of signals of probe tracking system output, described digital simulation display module is with data visualization, the direction of propagation of analog information probe positions and low-frequency vibration, and the hardness number of liver organization under current location and the direction.
After having taked above technical scheme, the quantitative information that propagation and ultrasound detection by low-frequency vibration can obtain hepatic fibrosis, adopt probe tracking system based on horseley-Clarke technique can obtain in the simulated three-dimensional space fibrosis information of liver on the different directions simultaneously, be used for assessing comprehensively, all sidedly the hepatic fibrosis degree.
Description of drawings
Fig. 1 is that liver fibrosis detection device of the present invention system forms sketch map.
Fig. 2 is a liver fibrosis detection device work sketch map of the present invention.
Fig. 3 is a liver fibrosis detection device principle schematic of the present invention.
The specific embodiment
The present invention is further elaborated with the specific embodiment with reference to the accompanying drawings below.
As shown in Figure 1, this liver fibrosis detection device is in order to detecting hepatic fibrosis, it comprise ultrasonic probe, the probe tracking system that is electrically connected with this ultrasonic probe, the signal processing module that is electrically connected with this ultrasonic probe and with this probe tracking system and signal processing module and computer that have systems soft ware.
As shown in Figure 2, this probe tracking system comprises telltale mark 1, detector 2 and the interface module 3 that is electrically connected with detector; This telltale mark 1 is fixed in patient's body surface three place's diverse locations to make up three dimensional space coordinate system, the positioner 6 that this detector 2 is followed the tracks of in the ultrasonic probe, and the acquisition ultrasonic probe is with respect to the space coordinates and the emission angle of space coordinates, this data signal is imported the computer 8 that survey plan software is housed into by interface module 3, this computer 8 that survey plan software is housed calculates angle and the path that ultrasound wave is propagated in liver, and intuitively shows on display screen.Comprise low-frequency vibration generator 4, ultrasonic transducer 5 and the positioner 6 that can supply the probe tracking system keeps track in this ultrasonic probe.This low-frequency vibration generator 4 is launched low-frequency vibration in body, ultrasonic transducer 5 is launched ultrasound wave in body simultaneously, survey the situation that the formed shearing wave of low-frequency vibration is propagated by echo-signal in liver organization, and coherent signal is passed to signal processing module 7.7 pairs of echo-signals of this signal processing module are also handled, and the signal after will handling simultaneously imports computer 8 into.The computer 8 that has systems soft ware comprises at least organizes hardness measuring and calculating module, probe orientation tracking module and digital simulation display module.This tissue hardness measuring and calculating module can be analyzed and calculate treated ultrasound echo signal, derives the hardness parameter of liver organization; This probe orientation tracking module can become the conversion of signals of probe tracking system feedback real-time coordinate and data; This digital simulation display module is with data visualization, but the direction of propagation of analog information probe positions and low-frequency vibration with reference to figure 3, can show and write down simultaneously the hardness number of liver organization under current location and the direction.Fig. 3 has shown that ultrasonic probe surveys with direction from different perspectives.
The above only is preferred embodiment of the present invention, and all equalizations of being done according to claim scope of the present invention change and modify, and all should belong to the covering scope of claim of the present invention.
Claims (5)
1. liver fibrosis detection device, fibrosis in order to liver in the detection bodies, it is characterized in that: described liver fibrosis detection device comprises ultrasonic probe, the probe tracking system that is electrically connected with described ultrasonic probe, the signal processing module that is electrically connected with described ultrasonic probe, and with described probe tracking system and signal processing module and computer that have systems soft ware, described ultrasonic probe is launched low-frequency vibration in body, utilize the formed shearing wave of the described vibration of supersonic sounding in liver organization, to propagate simultaneously, described probe tracking system constructing 3 d space coordinate is, and detect position and the angle of ultrasonic probe in real time with respect to hepatic tissue, described signal processing module collection is also handled the echo signal of telecommunication that probe obtains, and obtains the real-time quantitative information of hepatic fibrosis under corresponding coordinate and the angle by the Computer Processing analysis.
2. liver fibrosis detection device according to claim 1 is characterized in that: described probe tracking system comprises telltale mark, detector, and the interface module that is electrically connected with detector; Described telltale mark is fixed in patient's body surface at least three place's diverse locations to make up three dimensional space coordinate system, the described ultrasonic probe of described detector real-time detection is with respect to the space coordinates and the emission angle of space coordinates, data signal is imported the computer that survey plan software is housed into by described interface module, and the described COMPUTER CALCULATION that survey plan software is housed goes out angle and the path that ultrasound wave propagates and demonstrates in liver.
3. liver fibrosis detection device according to claim 1, it is characterized in that: comprise the low-frequency vibration generator in the described ultrasonic probe, ultrasonic transducer and the positioner that can supply the probe tracking system keeps track, described low-frequency vibration generator is launched low-frequency vibration in body, described ultrasonic transducer is launched ultrasound wave in body simultaneously, survey the formed shearing wave of low-frequency vibration by echo-signal and in liver organization, propagate, and coherent signal is passed to described signal processing module.
4. liver fibrosis detection device according to claim 1 is characterized in that: described signal processing module can be gathered the echo-signal of ultrasonic probe and handle, and the signal after will handling simultaneously imports computer into.
5. liver fibrosis detection device according to claim 1 is characterized in that: described computer comprises at least organizes hardness measuring and calculating module, probe orientation tracking module and digital simulation display module; The described hardness measuring and calculating module of organizing is analyzed and is calculated treated ultrasound echo signal, derive the hardness parameter of liver organization, described probe orientation tracking module becomes real-time coordinate and data with the conversion of signals of probe tracking system output, described digital simulation display module is with data visualization, the direction of propagation of analog information probe positions and low-frequency vibration, and the hardness number of liver organization under current location and the direction.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910105446XA CN101803933B (en) | 2009-02-13 | 2009-02-13 | Liver fibrosis detection device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910105446XA CN101803933B (en) | 2009-02-13 | 2009-02-13 | Liver fibrosis detection device |
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| CN101803933A true CN101803933A (en) | 2010-08-18 |
| CN101803933B CN101803933B (en) | 2012-11-07 |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030275A (en) * | 2015-08-31 | 2015-11-11 | 姜殿威 | Ultrasound exploration auxiliary positioning system |
| CN105147327A (en) * | 2015-06-12 | 2015-12-16 | 深圳大学 | Generation method for multi-frequency shear wave |
| CN105266851A (en) * | 2015-10-29 | 2016-01-27 | 无锡海斯凯尔医学技术有限公司 | Method and device for detecting viscosity parameter of viscoelastic medium |
| CN106344069A (en) * | 2016-10-13 | 2017-01-25 | 深圳大学 | Ultrasonic probe and ultrasonic imaging aided diagnosis system |
| CN106815840A (en) * | 2017-01-22 | 2017-06-09 | 飞依诺科技(苏州)有限公司 | A kind of processing method and processing device of liver's scanning image |
| CN109044402A (en) * | 2017-09-12 | 2018-12-21 | 乐普（北京）医疗器械股份有限公司 | A kind of Diagnosis of Fatty liver system based on Ultrasonic Elasticity Imaging |
| US11103216B2 (en) | 2014-12-24 | 2021-08-31 | Supersonic Imagine | Shear wave elastography method and apparatus for imaging an anisotropic medium |
| CN113456049A (en) * | 2021-06-23 | 2021-10-01 | 上海交通大学 | Liver cirrhosis detection system |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2843290B1 (en) * | 2002-08-08 | 2005-06-24 | Echosens | DEVICE AND METHOD FOR MEASURING THE ELASTICITY OF A HUMAN OR ANIMAL ORGAN |
-
2009
- 2009-02-13 CN CN200910105446XA patent/CN101803933B/en active Active
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11103216B2 (en) | 2014-12-24 | 2021-08-31 | Supersonic Imagine | Shear wave elastography method and apparatus for imaging an anisotropic medium |
| US11672509B2 (en) | 2014-12-24 | 2023-06-13 | Supersonic Imagine | Shear wave elastrography method and apparatus for imaging an anisotropic medium |
| CN105147327A (en) * | 2015-06-12 | 2015-12-16 | 深圳大学 | Generation method for multi-frequency shear wave |
| CN105147327B (en) * | 2015-06-12 | 2018-03-09 | 深圳大学 | A kind of production method of multi-frequency shearing wave |
| CN105030275A (en) * | 2015-08-31 | 2015-11-11 | 姜殿威 | Ultrasound exploration auxiliary positioning system |
| CN105266851A (en) * | 2015-10-29 | 2016-01-27 | 无锡海斯凯尔医学技术有限公司 | Method and device for detecting viscosity parameter of viscoelastic medium |
| CN105266851B (en) * | 2015-10-29 | 2018-01-05 | 无锡海斯凯尔医学技术有限公司 | The viscosity parameter detection method and equipment of viscoelastic medium |
| CN106344069A (en) * | 2016-10-13 | 2017-01-25 | 深圳大学 | Ultrasonic probe and ultrasonic imaging aided diagnosis system |
| CN106815840A (en) * | 2017-01-22 | 2017-06-09 | 飞依诺科技(苏州)有限公司 | A kind of processing method and processing device of liver's scanning image |
| CN109044402A (en) * | 2017-09-12 | 2018-12-21 | 乐普（北京）医疗器械股份有限公司 | A kind of Diagnosis of Fatty liver system based on Ultrasonic Elasticity Imaging |
| CN113456049A (en) * | 2021-06-23 | 2021-10-01 | 上海交通大学 | Liver cirrhosis detection system |
| CN113456049B (en) * | 2021-06-23 | 2023-11-17 | 上海交通大学 | Liver cirrhosis detecting system |
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| CN101803933B (en) | 2012-11-07 |
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Address after: No.1 Workshop A601, MeiXun digital technology factory, No.19 Jinxiu Middle Road, Laokeng community, Longtian street, Pingshan District, Shenzhen, Guangdong 518000 Patentee after: SHENZHEN ET MEDICAL TECHNOLOGY CO.,LTD. Address before: 4, Guangdong 518057, Shenzhen, Nanshan District science and Technology Park, Sunny Hill, two clean Sunshine Garden Patentee before: SHENZHEN ET MEDICAL TECHNOLOGY CO.,LTD. |
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