CN101801336A - Dentrifice composition - Google Patents

Abstract

A dentifrice composition that includes: i) 0.1 to 5% by weight zincsalt; ii) 0.01 to 1.0% by weight polyethylene oxide having molecular weight of from 100,000 to 8,000,000 g/mol; and iii)10 to 70% by weight of a humectant.

Description

Dentrifice composition

The present invention relates to dentifrice (dentifrice), particularly toothpaste relates more specifically to contain zinc salt, shows the toothpaste of low astringent taste simultaneously.

This description any prior art is in the whole text discussed and should be regarded as in no case admitting that this class prior art is a part that is widely known by the people or constitute the general general knowledge in this area.

It is as known in the art that zinc salt is mixed in the Dentrifice composition to alleviate halitosis (oral malodour) valuably.But the astringent taste of zinc salt is the major defect in its application in Dentrifice composition, and it causes unacceptable astringent taste in mouth.In addition, the effectiveness of its antiplaque, calculus and halitosis development is of short duration.Usually, zinc and anionic counter ion counterionsl gegenions as its astringent taste of complex formation reduction of citrate, but also reduce its dissolubility and/or bioavailability.

For overcoming and/or alleviate the astringent taste of the dentifrice that contains zinc salt, the past has been made various trials.

EP0162574 (1985, Johnson﹠amp; Johnson) described by using general stream Buddhist nun gram (pluronic) type polymer, promptly poly(ethylene oxide)-poly(propylene oxide) block copolymer alleviates astringent taste as surfactant.Although the inventor has been found that this has realized alleviating of astringent taste, it is still expensive selection.

Similarly, EPO251542 (1988, Lion Corporation) has described the astringent taste that use polyoxyethylene-castor oil hydrogenated alleviates zinc salt.

Need alleviate the better mode of renewal of the astringent taste effect of the Dentrifice composition that contains zinc salt.

An object of the present invention is to provide and comprise zinc salt, have the Dentrifice composition of relatively low astringent taste simultaneously.

The purpose of this invention is to provide the Dentrifice composition that produces the breath freshening degree that improves.

The inventor has been found that by using poly(ethylene oxide) and wetting agent, can significantly alleviate the astringent taste aftereffect (after-effect) that is associated with the Dentrifice composition that contains zinc salt.

The inventor observes surprisingly, and said composition shows significant astringent taste and alleviates, and said composition also obviously provides anti-halitosis protection for more time after continuing use simultaneously.

According to an aspect of the present invention, provide Dentrifice composition, it comprises:

(i) 0.1 to 5 weight % zinc salt;

(ii) 0.01 to 1.0 weight % molecular weight is 100,000 to 8,000, the poly(ethylene oxide) of 000 gram/mole; With

(iii) 10 to 70 weight % wetting agent.

It preferably includes 0.1 to 2 weight % zinc salt.

It is 100,000 to 8,000 that said composition preferably includes 0.1 to 0.5 weight % molecular weight, the poly(ethylene oxide) of 000 gram/mole.

This description in the whole text in, " high molecular weight polyethylene oxide used according to the invention " should be understood to mean molecular weight is 100,000 to 8,000, the poly(ethylene oxide) of 000 gram/mole.

This zinc salt is preferably selected from zinc chloride, zinc sulfate or zinc citrate, and it is more preferably zinc sulfate.

According to a further aspect in the invention, the method of making Dentrifice composition is provided, comprises that with 0.1 to 5 weight portion zinc salt and 0.01 to 1 weight portion molecular weight be 100,000 to 8, the poly(ethylene oxide) of 000,000 gram/mole and 10 to 70 weight portion wetting agent and suitable mixed with excipients.

The purposes of Dentrifice composition of the present invention is provided according to a further aspect in the invention.

Term used herein " dentifrice " is meant the material that is used for cleaning teeth, and it is fit to apply and wash off after use with toothbrush.It can be cream (paste), gel or liquid preparation.Dentrifice composition can be single-phase, two-phase or heterogeneous goods in this article, (core in sheath) as deep layer striped (deepstriped), striated surface (surface striped), multiwalled, Bao Xin, example gel parcel mastic, or their any combination.

Single-phasely can comprise liquid-carrier, wherein homodisperse one or more soluble granules, as the granule of abrazine.

When this Dentrifice composition comprises more than a phase time, in the compartment of the described physical separation that can be contained in allotter mutually and distribute side by side, or they can be contained in and make their directly in packing of contact.

A kind of necessary component of Dentrifice composition of the present invention is a zinc salt.Zinc salt is effective antimicrobial.

This zinc salt preferably have at least 0.1 the gram/100 the gram water dissolubility, if but with other solubilising material, unite use as sodium citrate, then soluble material can provide solvable zinc salt as zinc oxide.

Available zinc salt comprises zinc chloride, zinc sulfate, zinc nitrate, zinc citrate, zinc gluconate, zinc acetate, zinc lactate and zinc salicylate among the present invention.

Also can use salt-mixture, as sodium citrate zinc.Preferred zinc salt is the organic acid zinc salt, as zinc citrate, zinc lactate, MALEIC ACID, ZINC SALT, zinc salicylate, zinc gluconate and ascorbic acid zinc.But most preferred salt is zinc sulfate.Can use the mixture of different zinc salts.This zinc salt is preferably with about 0.1 to 5 weight %, preferably approximately 0.1 mixes in the oral care composition of the present invention to the concentration of about 2 weight %, and zinc salt content most preferably is 0.1 to 0.5 weight %.Excess zinc can cause the astringent taste of unacceptable taste and higher degree, and may cause the consistency problem with other composition, for example precipitation of anionic polymer.

Do not wish to be limited by any theory, but it is believed that molecular weight used among the present invention is 100,000 to 8,000, the poly(ethylene oxide) of 000 gram/mole provides smooth feeling and lubricated more thus oral cavity for the oral cavity.This molecular weight is preferably 600,000 to 2,000,000 gram/mole, more preferably 800,000 to 1,000,000 gram/mole. It is the trade name of the high molecular weight polyethylene oxide of Dow Chemicals production.Particularly preferred material is passable

WSR 301-NF runs after fame available from Dow Chemicals.The available quantity of high molecular weight polyethylene oxide used according to the invention be said composition about by weight 0.01% to about 1%, preferably approximately 0.1% to about 0.5%, most preferably 0.1% to 0.2%.The more high-load of this class poly(ethylene oxide) causes its scattering problem in medium according to observations.

Dentrifice composition of the present invention is included in and strengthens fragrance in the mouth, prevents astringent taste and the wetting agent of fresh and comfortable sense is provided.It also prevents the dentifrice caking.Wetting agent is used for preventing hardening and also can giving the desirable sweet taste of said preparation when Dentrifice composition is exposed to air minimizing with the astringent taste that zinc salt is caused.Wetting agent is preferably with about 10-70 weight %, and more preferably approximately the total amount of 25-60 weight % exists.Typical case's wetting agent comprises Sorbitol (adding with 70% aqueous solution form usually), glycerol, maltose alcohol and xylitol.This dentifrice most preferably contains about 16-30% glycerol in opaque cream (cream) base, and the clear gel compositions is used the combination of 10 to 30 weight % glycerol and 30 to 50 weight % Sorbitols (as 70% aqueous solution form).Do not have any other wetting agent for avoiding query, supposing, the gel combination that comprises 20 weight % glycerol and 40 weight % Sorbitols (70% aqueous solution form) comprises the wetting agent that total amount is 48 weight % (20+[40 * 0.70]).

Sorbitol solution provides sweet taste and body and produces desirable mouthfeel for said composition.For lubricated mouthfeel, preferably use the mixture of glycerol and Sorbitol.

Usually, the sweeting agent of empoly effective amount is to provide required sugariness.This amount becomes with selected sweeting agent and said composition.

The amount of the general sweeting agent that exists be about 0.0025 weight % about 60 weight % extremely of this Dentrifice composition.

When needs basically during the gel of visually-clear, there is not water usually, usually about 2-5 weight % more than 10%.When this dentifrice is opaque, may there be more substantial water.The preferred deionization and free from foreign meter of used water in the preparation of commercial suitable dentifrice.Water constitutes about 0.05 to 70.0 weight % of this preparaton, preferably approximately 15.0 to 50.0 weight %.These water yields comprise the water of interpolation and with other material, the water of introducing together as 70% aqueous sorbitol solution.

For the transparent dentifrice agent, the liquid phase of preferably allocating compositions of the present invention is so that the refraction index of the silicon dioxide that also exists in its refraction index approximate match said composition.This liquid phase comprises water and wetting agent usually, and the latter is Sorbitol or glycerol normally.Glassware for drinking water has 1.333 RI (refraction index); Sorbitol (70% aqueous solution) has 1.457 RI, and glycerol has 1.473 RI.Can calculate the refraction index of this liquid phase by the refraction index separately of constituent.

Compositions of the present invention can contain other optional member, as long as do not damage the clarity of the dentifrice of gel form thus, and the RI of this liquid phase is roughly the RI of low refractive index abrasive material silicon dioxide.

Another preferred component is water soluble fluoridized compounds, and its consumption is enough in said composition to produce about 0.0025 weight % and renders a service so that dental caries to be provided to the fluoride concentration of about 0.5 weight %.The material that can use multiple generation fluorion is as the soluble fluoride source in this compositions.Representative fluoride ion sources comprises stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate or the like.Stannous fluoride and sodium fluoride and their mixture are preferred especially.

But, if sodium fluoride and long chain polyphosphate are united use, then its preferably remain on independent mutually in.

Dentifrice of the present invention can also contain the coloured particle that is suspended in wherein, and for example coloured silicon dioxide agglomerate or other coloured particle are to give this dentifrice " speckle " outward appearance.Coloring agent can be the aqueous solution form, preferably the aqueous solution of 1% coloring agent.Coloring solution constitutes 0.01 weight % to 5 weight % of said composition usually.

Also can in this compositions, add titanium dioxide.Titanium dioxide is the white powder that increases the opacity of said composition.Titanium dioxide can constitute 0.25 weight % to 5 weight % of said composition.

Except high molecular weight polyethylene oxide used according to the invention, can in compositions of the present invention, mix other gellant or binding agent, as natural and organic thickening agent synthetic colloidal substance.The example of this class thickening agent is carrageenin (Irish moss), xanthan gum, sodium carboxymethyl cellulose, starch, polyvinyl pyrrolidone, ethoxy propyl cellulose, hydroxy butyl methyl cellulose, hydroxypropyl emthylcellulose and hydroxyethyl-cellulose.

Compositions of the present invention can also comprise that molecular weight is less than 100,000 poly(ethylene oxide).Usually comprise this class material, for example polyethylene glycol 1500 is to improve the cohesiveness (cohesion) of said composition.

Organic thickening agent can with said composition about 0.25 to about 2 weight %, preferably approximately 0.5 mix in the compositions of the present invention to the concentration of about 1 weight %.Also can use the pyrolytic silicon dioxide synthetic in small, broken bits of the amount of about 1-5 weight %, as with trade mark CAB-0- M-5,

244,

266 know Those that D-200 sells are with thickening or the gelling that promotes this dentifrice.

In Dentrifice composition of the present invention, also can use antibacterial as known in the art so that the total content of this class reagent of about 5 weight % at most to be provided.

Can be by using suitable seasoning or increasing the taste that sweet material improves said composition.The example of suitable flavoring ingredients comprises flavored oils, for example, Herba Menthae Rotundifoliae, Mentha arvensis L. syn.M.haplocalyxBrig, Ilicis Purpureae, yellow Camphor tree, Flos Caryophylli, Salvia japonica Thunb., Eucalyptus, Origanum majorana L., Cortex Cinnamomi, oil of Fructus Citri Limoniae and Fructus Citri junoris and methyl salicylate, wintergreen oil, Fructus Piperis peppermint oil, Oleum Menthae Rotundifoliae, clove bud oil, menthol, anethole, methyl salicylate, eucalyptole, Cortex cinnamomi japonici (Ramulus Cinnamomi), acetic acid 1-menthyl ester, Salvia japonica Thunb., eugenol, parsley oil, oxanone, α-Zi Luolantong, Origanum majorana L., Fructus Citri Limoniae, Fructus Citri junoris, 1-ethoxy-2-hydroxy-4-propenyl benzene, Cortex Cinnamomi, vanillin, ethyl vanillin, heliotropine, 4-cis-heptenal, biacetyl, methyl-right-tert-butyl benzene yl acetate, and composition thereof.

The seasoning system is used in the said composition with the content of 0.001 weight % to 5 weight % of said composition usually.The interpolation of flavouring agent (flavor) is a metallic aftertaste of taking zinc salt into account.

Said composition also preferably includes coolant agent (coolant).Preferred coolant agent is to the menthane carboxamides agent in this compositions, as N-ethyl-right-terpane-3-carboxylic acid amides (commercial being called " WS-3 ") and with the mixture (commercial being called " MGA ") of menthone glycerine acetal.

Suitable sweeting agent comprises sucrose, lactose, maltose, Sorbitol, Sodium Cyclamate (sodium cyclamate), perillartine and glucide.The present invention can also comprise xylitol.Xylitol is the sugar alcohol as sweeting agent and wetting agent.Xylitol can provide therapeutical effect, as antibiotic or dental caries effect.

This compositions comprises usually and accounts for 0.01% to 25% of total composition by weight, and is preferred 3% to 15%, and more preferably 5% to 12%, the xylitol of 9% to 11% content most preferably.Perhaps, if use xylitol as sweeting agent, it can lower amount exist, as 0.005 weight % to 5 weight % of this Dentrifice composition.

The surface-active contents that this paper enumerates is based on 100% activity, although common raw materials may provide with more SA water-soluble form as sodium lauryl sulphate.This surfactant is important to oral cavity cleaning, no matter is thoroughly removing aspect the dirt from the surface or generating foam aspect the dirt of removing that suspends.Suitable surface-active contents be total composition about by weight 2% to about 15%, preferably approximately 2.2% to about 10%, more preferably about 2.5 to about 5%.The surfactant that this paper is suitable for comprises anionic, amphoteric, nonionic, amphoteric ion type and cationic surface active agent, but anionic, amphoteric, nonionic and amphoteric ionic surfactant (and composition thereof) be preferred.

Usually comprise abrasive material in the said composition.Abrasive material can be selected from metaphosphate, calcium carbonate, aluminate and the silicate of water-insoluble alkali metal or alkaline-earth metal.Especially preferred is silicon dioxide, dicalcium phosphate and calcium carbonate.The amount of abrasive material be said composition about 5 to about 80 weight %.Same suitable is Chalk type abrasive material, and as calcium carbonate and magnesium carbonate, silicon dioxide comprises xerogel, hydrogel, aeroge and precipitate, aluminium oxide and hydrate thereof.

Abrasive material comprises alpha-aluminium oxide trihydrate, aluminosilicate, as calcined aluminosilicate and aluminium silicate, magnesium silicate and Zirconium orthosilicate., and as magnesium trisilicate, and thermosetting polymer resin, as granular condensation product, polymethyl methacrylate, the polyethylene powder of urea and formaldehyde.Also can use the mixture of abrasive material.

Polish abrasive has about 0.1 to about 30 microns usually, preferably approximately 5 to 15 microns particle mean size.

Various types of silicon dioxide dentistry abrasive materials provide outstanding cleaning of teeth and polishing performance under not excessive wear enamel or Dentinal situation.Abrasive silica can be precipitated silica or silica gel, for example W.R.Grace﹠amp; Company, Davison ChemicalDivision is with trade name

The silica xerogel of selling.Suitable precipitated silica material comprises that J.M.Huber Corporation is with trade name

119 or

Those of 118 sales.Suitable abrasive material content be said composition about by weight 1% to about 40%, preferably about at least 2%, more preferably about at least 5% as about 2% to about 20%, as about 5% to about 15%.

Can in compositions of the present invention, mix tartar controlling agent, especially effectively phosphorus reagent.Phos tartar controlling agent can comprise any water solublity pyrophosphate, as the mixture of disodium pyrophosphate, Dipotassium pyrophosphate and these and tetrapotassium pyrophosphate or tetrasodium pyrophosphate.

The organic phosphorus compound that can serve as the tartar controlling agent comprises polyphosphonate, as ethane-1-hydroxyl-1, and 1-Alendronic acid disodium salt (EHDP) and first di 2 ethylhexyl phosphonic acid.

Usually, compositions of the present invention has 5 to 8, and is preferred 6.5 to 7.5, for example 7 pH value.

The invention still further relates to the method for making Dentrifice composition, comprise that with 0.1 to 5 weight portion zinc salt and 0.01 to 1 weight portion molecular weight be 100,000 to 8,000, the poly(ethylene oxide) of 000 gram/mole and 10 to 70 weight portion wetting agent and suitable mixed with excipients.

In order to prepare Dentrifice composition of the present invention, can be with wetting agent in conventional mixer, as glycerol and Sorbitol, polyphosphazene polymer oxirane used according to the invention and zinc salt add in the water and mixed 10 to 15 minutes.After this, can add optional member, for example silicon dioxide and carboxymethyl cellulose continue to mix 10 to 15 minutes again, add surfactant then.This mixture can be outgased under vacuum subsequently.Add seasoning and coloring components subsequently, continue again to mix 10-15 minute, and further under vacuum, outgas.Products therefrom is the similar ordinary gel of quality and have the stable dentifrice of gratifying fragrance normally.

Be explained in more detail the present invention by following non-limiting examples now.

Embodiment 1

Make bag core pattern toothpaste, its SMIS and skin are gels.The composition of said composition (compositions 1) is listed in the table 1.Similarly, make placebo toothpaste (gel), it contains all the components except that zinc sulfate.By extra interpolation low amounts of water, polishing surplus.

Table-1

Chemical name	??％w/w
		Silicon dioxide-abrasive material	??9.00
Silicon dioxide-thickening	??9.00
		Sorbitol	??40.00
Anhydrous-adjacent sulfonamides (anhydro-o-sulphamine) sodium benzoate	??0.25
		Titanium dioxide	??0.02
Sodium lauryl sulphate	??2.00
		Sodium carboxymethyl cellulose	??0.60
Polyethylene glycol 1500	??2.00
		Sodium fluoride	??0.32

Chemical name	??％w/w
		SENTRY (TM) POLYOX (TM) WSR 301-NF GRADE is from Dow Chemicals molecular weight 100000-8000000 gram/mole	??0.20
Flavouring agent	??1.15
		Glycerol	??26.00
Sodium hydroxide (10% solution)	??0.30
		Zinc sulfate	??0.20
Water and other less important thing	To 100%

The performance of comparative composition 1 and placebo toothpaste.

Sense organ research

190 volunteer's sense of participation bureaucratic airs flavors research in the healthy 18-45 age group (masculinity and femininity).All volunteers are age-based, sex and the grouping of baseline mark.The volunteer has at least 24 teeth, and wherein at least 20 teeth do not have tooth or gum disease.They are required to avoid using antibiotic 3 weeks before test and are required before test to avoid at least 2 hours oral cavity activity (brush teeth, gargle, wash, take food, drink water, chew gum, smoking).The volunteer is at each maror and do not take in ethanol in checking preceding 24 hours each of not taking food in checking preceding 24 hours.

Four sense organ evaluations of being trained participate in giving a mark for the volunteer.These evaluations also are required to avoid drinking hot beverage, smoking, absorption ethanol or make in research process to apply some make up.Allow each volunteer close the oral cavity 60 seconds and in this process, do not swallow.After 1 minute, the volunteer is lightly by apart from air in the pipe expiratory port of 5 centimetres of the about 10 centimetres 24 millimeters/length of diameter of the nose of abnormal smells from the patient evaluation, and evaluation is ensconced behind the screen and immediately with 0-5 sense organ grade recording odor.

0 to 5 sense organ grade is as follows:

0 does not exist stink.

1 inadequate perceptible stink.Stink low-intensity and in the acceptable limit of sense organ.

2 slightly to moderate odor.Stink is obviously discernable and not desirable slightly.

3 medium paramount stinks.The obvious perceptible not desirable stench of moderate strength.

4 high-intensity fetors.

5 stenches extremely

Require all volunteers before obtaining baseline, not brush teeth in 12 hours.Only select the implication mark be 3 or＞3 volunteer carries out this research.Behind the baseline mark, allow them brush teeth 3 minutes with the toothpaste of 1 whole head length, gargle with 25 ml waters then.Require each volunteer not drink water and take food and finish until evaluation and test.Is that the volunteer gives a mark at all time points by at least two evaluations: (brushed teeth last time back 12 hours) before brushing teeth, brushed teeth back 10 minutes and brushed teeth back 2 hours.Carrying out all with the t-check analyzes with the significance of derivation under 95% confidence level.

The result is summarised in the following table 2.

Table-2

^*Comp-1 is a compositions 1

Therefore find out that compositions 1 just significantly alleviated the halitosis degree at the 1st day, though brush teeth back 2 hours also like this.

In addition, compositions 1 continue to be used 4 weeks (twice of every day) even before brushing teeth in the back (after promptly brushing teeth 12 hours apart from last time, whole night) also significantly alleviate the halitosis degree, and in this case, the placebo mark after brushing teeth 2 hours and the difference of compositions 1 mark are very obvious.Therefore this show that said composition can obviously provide anti-halitosis protection for more time after continuing use.

Halimeter research

In addition, also check The above results, because this is a reliable analytical method directly and more by the volatile sulfur content of analyzing in volunteer's implication (VSC).Use is known as the Instrumental Analysis volunteer's of halimeter implication, and this instrument detecting also shows VSC content with ppb (1,000,000,000/umber).

In this case, also test after continuing to use for 2 and 4 weeks, 188 volunteers in the 18-45 age group (masculinity and femininity) participate.

All volunteers are age-based, sex and the grouping of baseline mark, and this is parallel group of controlled design studies.In this research, comprise VSC mark＞120ppb and＜all volunteers of 250ppb.

They are required to avoid using antibiotic 3 weeks before test and are required before test to avoid at least 2 hours oral cavity activity (brush teeth, gargle, wash, take food, drink water, chew gum, smoking).The volunteer avoids the maror of taking food at every turn in checking preceding 24 hours.

They also avoid taking in ethanol at every turn in checking preceding 24 hours.Use Halimeter that each volunteer is carried out halitosis and measure (meansigma methodss of 3 readings).In the morning of each test, the volunteer did not take in any food/confection or does not use any collutory before their baseline estimate.The volunteer does not take food during each the inspection and drinks water.Behind baseline estimate, the volunteer brushed teeth 2 minutes with the suitable dentifrice of 1 whole head length.Brush teeth preceding 12 hours, brushed teeth back 10 minutes and brushed teeth back 2 hours, use Interscan Halimeter Model RH-17K (S.O.P.) to carry out halitosis and measure.

The baseline reading of two group of products is complementary.Analyze to obtain the significance under 95% confidence level with " t-check ".To contrast toothpaste and compositions 1, all after product used for 4 weeks, follow the program of above-mentioned short-term design, and brush teeth preceding 12 hours, brushed teeth back 10 minutes and brushed teeth and on halimeter, measured in back 2 hours.

Be summarised in the following table 3 with the back 2 hours result that brushes teeth before brushing teeth.

Table-3

^*Comp-1 is a compositions 1

Therefore as can be seen, according to the compositions 1 remarkable VSC content that reduces according to the present invention, all the more so after continuing to use for 2 and 4 weeks.

Except that above-mentioned experiment, the volunteer who has used each 4 week of compositions is and self assessment compositions 1 and placebo are being chosen as 0 to 5 grade in the pure and fresh degree value of the contrast after the use and after finishing during this period with it, and 0 is minimum, and 5 is best.The result is summarised in the following table-4.

Table-4

^*Comp-1 is a compositions 1

These results show that the pure and fresh degree mark of compositions 1 is higher than placebo, especially after brushing teeth and after brushing teeth 2 hours.

Embodiment 2

In another group experiment, make the compositions that contains 0.2,0.4 and 0.7% zinc sulfate, wherein identical in prescription and the table 1 is the content raising/reduction of zinc sulfate, and the water content in the corresponding prescription correspondingly improves/reduces.

BDCOH (4,4 '-two (dimethylamino) benzohydrol) content before and after brushing teeth by research in the saliva, the effectiveness of evaluation and test dentifrice.This also is the indication of halitosis degree.

BDCOH Study on content in the implication

Rules in the body

From 50 volunteers (each name), collect about 2 milliliters of saliva samples in the plastics phial that hot-pressing processing is crossed before brushing teeth and before the feed in the morning.Diluted sample is added BDCOH solution to different dilution factors and in phial.In the SpectraMax plate reader, read titer plate, and calculate the concentration of saliva mercaptan at 620nm.This and saliva concentrations of mercaptans are inversely proportional to.

Rules exsomatize

35 saliva samples that the volunteer is not excited in 0 time, the generation in back 2 hours of brushing teeth back 30 minutes and brushed teeth in the back of brushing teeth with placebo and compositions 1.The saliva concentrations of mercaptans of test sample after using BDCOH to cultivate 24 hours.In the SpectraMax plate reader, read titer plate, and calculate the concentration of saliva mercaptan at 620nm.

BDCOH concentration is high more, and the concentration of saliva mercaptan is low more in the saliva sample of cultivation.

Result's (BDCOH value) collects in the following table 5.

Table-5

Numerical value in the last table shows that BDCOH content shows and significantly improves after brushing teeth, especially for containing the compositions of 0.2 to 0.7% zinc sulfate.This shows, even compositions of the present invention also can significantly prevent to cause the formation of the saliva mercaptan of stink after brushing teeth 2 hours.

Except anti-halitosis benefit was provided, compositions of the present invention also provided other desirable consumer's interests.

Prepare following compositions, Comparative Examples 1, and used for 1 week, twice of every day by 200 volunteers.After this, they are chosen as the compositions of the present invention that is equivalent to or is better than as in the table 1 with the desirable interests of various consumers of said composition.

According to the prescription in the following table 6, the compositions of preparation Comparative Examples 1.

Table-6

Composition	%w/w (Comparative Examples 1)
		Silicon dioxide-abrasive material	??0.5
Silicon dioxide-abrasive material	??8.0
		Silicon dioxide-thickening	??9.5
Sorbitol	??65.0
		Anhydrous-o-sulfaminobenzoic acid sodium	??0.2
Titanium dioxide	??0.02

Composition	%w/w (Comparative Examples 1)
		Sodium lauryl sulphate	??2.0
Sodium carboxymethyl cellulose	??0.6
		Polyethylene glycol 1500	??2.0
Sodium fluoride	??0.3
		Zinc sulfate	??0.2
Treated water and other less important thing	Surplus to 100%

The corresponding ratings that the volunteer provides these compositionss is summarised in the following table 7.

Table-7

The benefit that the volunteer needs	The compositions of preference: compositions 1vs. Comparative Examples 1
		Make tooth, gums and tongue feel smooth	Quite
Help to massage tooth and gums	Compositions 1
		Make the oral cavity be immersed in a few hours in the cool and sweet-smelling sense	Compositions 1
Generation is than the better pure and fresh sense of used existing product	Compositions 1
		Has the pure and fresh sense that makes the oral cavity salubrious	Compositions 1
Produce fine and smooth lubricated foam (reverse side of astringent taste)	Compositions 1
		Stay smooth, clean and salubrious oral cavity (reverse side of astringent taste)	Compositions 1
In mouth, stay smooth feeling (reverse side of astringent taste)	Compositions 1
		Give long-term pure and fresh sense	Compositions 1

Data in the table 7 show that aspect most of important attribute, the volunteer likes compositions 1 to surpass Comparative Examples 1.

Last table shows, compositions 1 (according to the present invention) is compared with the preparaton of pbz polymer amount poly(ethylene oxide) not can realize most of desirable consumption attributes.

In addition, also by 15 specialized review member comparative composition 1 and Comparative Examples 1.The purpose of this research is evaluation and test and compares mouthfeel, foam degree, flavor strength and fragrance association attributes.

The evaluation member brushed teeth 60 seconds with 1 whole head length.They use 0 to 10 lineal scale to assess various attributes, and the 0th, minimum branch, the 10th, best result.The average result of their comparative assessment collects in the following table 8.

Table-8

Attribute	Compositions 1	Comparative Examples 1
			Zest	??5.56	??5.52
Nice and cool property	??5.60	??5.58
			Oral cavity fresh and cool	??5.60	??5.58
The astringent taste mark	??4.00	??5.00

Mark from table 8 (particularly relative astringent taste mark) and the data from last table 7 are clear finds out that compositions 1 according to the present invention is compared with the astringent taste of Comparative Examples 1 has much lower astringent taste mark.

Will appreciate that illustrated embodiment provides and comprises that zinc salt has the Dentrifice composition of relatively low astringent taste simultaneously.

Will appreciate that also illustrated embodiment provides the breath freshening degree that produce to improve, particularly the Dentrifice composition of breath freshening degree whole night.

Although described the present invention, those of skill in the art will recognize that the present invention can be embodied as many other forms with reference to specific embodiments.

Claims (14)

1. Dentrifice composition, it comprises:

I.0.1 to 5 weight % zinc salts;

Ii.0.01 to 1.0 weight % molecular weight is 100,000 to 8,000, the poly(ethylene oxide) of 000 gram/mole; With

Iii.10 to 70 weight % wetting agent.

2. Dentrifice composition as claimed in claim 1, it comprises 0.1 to 2 weight % zinc salt.

3. Dentrifice composition as claimed in claim 2, it comprises 0.1 to 0.5 weight % zinc salt.

4. each described Dentrifice composition in the claim as described above, it comprises the described poly(ethylene oxide) of 0.1 to 0.5 weight %.

5. each described Dentrifice composition in the claim as described above, wherein said zinc salt is selected from zinc chloride, zinc sulfate or zinc citrate.

6. Dentrifice composition as claimed in claim 5, wherein said zinc salt is a zinc sulfate.

7. each described Dentrifice composition in the claim as described above, the molecular weight of wherein said poly(ethylene oxide) is 600,000 to 2,000,000 gram/mole.

8. Dentrifice composition as claimed in claim 7, the molecular weight of wherein said poly(ethylene oxide) are 800,000 to 1,000,000 gram/mole.

9. each described Dentrifice composition in the claim as described above, wherein said wetting agent comprises glycerol and Sorbitol.

10. each described Dentrifice composition in the claim as described above, wherein said compositions comprises flavouring agent.

11. make method, comprise with 0.1 to 5 weight portion zinc salt according to each dentifrice in the aforementioned claim; 0.01 to 1.0 weight portion molecular weight be 100,000 to 8,000, the poly(ethylene oxide) of 000 gram/mole and 10 to 70 weight portion wetting agent mix with water.

12. as described above in the claim 1 to 10 each described dentifrice as the purposes of medicine.

13.0.1 to 5 weight % zinc salts; 0.01 to 1.0 weight % molecular weight be 100,000 to 8,000, the poly(ethylene oxide) of 000 gram/mole; Be used for improving situations of teeth and/or improving the purposes of manufacturing of the Dentrifice composition of breath freshening degree with 10 to 70 weight % wetting agent.

14. the basic Dentrifice composition of describing as the appended embodiment of this paper.