CN101798046B - Method for filling ammonia and capping for amino acid injection - Google Patents

Abstract

The invention discloses a method for filling nitrogen and capping for amino acid injection and relates to a method for capping medicament bottles in the field of production of amino acid injection medicaments. The method for filling nitrogen and capping for the amino acid injection comprises the following steps of: pre-filling nitrogen before a glass bottle enters a capping machine; making the glass bottle enter a working chamber through a positioning dial, and pre-filling nitrogen in the chamber for four seconds, wherein the nitrogen pressure is 0.2 to 0.3MPa; and after the glass bottle completely enters the chamber, sealing the chamber, reducing the nitrogen pressure to 0.1MPa, and continuously filling the nitrogen for 1.5 seconds; evacuating the glass bottle to the pressure of 0.03MPa below zero for 0.5 second; opening a suction plug by the suction plug valve stroke simultaneously, wherein the pressure is 0.06MPa below zero, and evacuating the glass bottle while opening the suction plug, and discharging the capped glass bottle out of the capping machine. Through the steps, resident oxygen in the glass bottle is less than 2 percent, and the capping success rate is over 99 percent.

Description

A kind of amino acid injection fills nitrogen and beats blocking method

Technical field

The present invention relates to the upper blocking method of medicine bottle in amino acid injection medicament production field, particularly a kind of amino acid injection that requires low remaining oxygen fills nitrogen and beats blocking method.

Background technology

Amino acid fills nitrogen, and to play plug be one important procedure in amino acid injection production process, by technological requirement, residual oxygen in the glass bottle of amino acid injection is controlled at below 2%, thereby guarantees that amino acid never degenerates within storage period, guarantees the quality of medicine.

At present, most of pharmacy corporation filling nitrogen corking equipments are that traditional needle tubing fills nitrogen, remain on the place of bottleneck top 3-5 millimeter, after substituting the bad for the good, enter into rear single-revolution equipment and play plug, it fills residual oxygen after nitrogen generally in 8% left and right, top plug success ratio only has 92% left and right, can not meet the needs of pharmaceutical industry far away.The residual oxygen of injection that an above nitrogen filling method and equipment to meet the need is not high is controlled and is needed, and the residual oxygen that can not meet amino acid injection is controlled requirement.

Chinese patent " 2006200517911 " (publication number " 2937086 " open day " 2007-08-22 ") discloses a kind of < < glass bottle vacuum-pumping nitrogen-filled stopper applying device > >, adopted on suction chock plug and be provided with chuck, described chuck and described depression bar adopt sealed sliding to be dynamically connected, on described chuck, strand is equipped with claw, between described claw and described chuck, be provided with spring, described chuck i.e. described claw can enter in described adapter sleeve and enter rear described claw and can protect gathering, at described adapter sleeve outlet end, be provided with the inner bushing ring that described claw is opened.Can effectively guarantee like this to inhale the absorption of chock plug to plug, improve the reliability of inhaling plug and tamponade.Adopt this structure, thereby reach the object that remaining oxygen is less than 2% through vacuumizing and filling nitrogen after repeated multiple times.

Summary of the invention

Technical matters to be solved by this invention is to provide a kind of amino acid injection and fills nitrogen and beat blocking method, residual oxygen in glass bottle can be controlled at below 2%, and top plug success ratio is more than 99%.

For solving the problems of the technologies described above, the technical solution adopted in the present invention is: a kind of amino acid injection fills nitrogen and beats blocking method, comprises the following steps:

Glass bottle fills in advance nitrogen before entering dozen plug machine, and glass bottle enters work chamber by location driver plate, and chamber fills nitrogen in advance, and nitrogen pressure is 0.2-0.3 MPa, and the time is 4 seconds;

Enter completely after cavity seal, reduce nitrogen pressure and continue inflated with nitrogen to 0.1MPa, the time is 1.5 seconds;

Vacuumize, pressure is-0.03MPa that the time is 0.5 second;

Suction obturator valve stroke is opened, and inhales plug, and pressure is-0.06MPa also to vacuumizing in glass bottle, to play the rear glass bottle of plug and go out to beat plug machine when suction obturator valve is opened;

Through above-mentioned steps, residual oxygen < 2% in glass bottle, top plug success ratio > 99%.

A kind of amino acid injection provided by the invention fills nitrogen and beats blocking method, is filled nitrogen pressure, is extended and fill the nitrogen time, and control opportunity and the pressure vacuumizing by control, and the residual oxygen of having realized in glass bottle is controlled at below 2%, and top plug success ratio is more than 99%.

Accompanying drawing explanation

Fig. 1 is the integral structure schematic diagram of making plug machine in the present invention.

The specific embodiment

Initial improving one's methods as filling nitrogen and vacuumizing cooperation repeatedly, but vacuumize and to fill nitrogen larger for the success ratio impact of top plug, mainly to have reduced the adsorption effect of inhaling chock plug, thereby reduced top plug success ratio, and inflated with nitrogen, the mechanical valve running frequency that vacuumizes are high, quick abrasion, affects its service life.

Need to when controlling glass bottle 7 interior residual oxygen < 2%, guarantee that top plug success ratio > 99% is more difficult, through repeatedly improving, final scheme is as follows:

In Fig. 1, a kind of amino acid injection fills nitrogen and beats blocking method, and glass bottle 7 fills in advance nitrogen before entering dozen plug machine, and glass bottle 7 enters chamber 6 by location driver plate, and nitrogen fill valve 3 is opened, and fills in advance nitrogen in chamber 6, and nitrogen pressure is 0.2-0.3 MPa, and the time is 4 seconds;

Enter completely after chamber 6 sealings, reduce nitrogen pressure and continue inflated with nitrogen to 0.1MPa, the time is 1.5 seconds; Reducing nitrogen pressure has avoided, on inhaling the impact of plug, filling for a long time nitrogen and making the air displacement in glass bottle 7 abundant.

Vacuum pumping valve 4 is opened and is vacuumized, and pressure is-0.03MPa that the time is 0.5 second;

Inhale obturator valve stroke simultaneously and open suction chock plug 2 suction plugs, pressure is-0.06MPa, when inhaling obturator valve and open also to vacuumizing in glass bottle 7, because the negative pressure vacuumizing in chamber 6 is less than the negative pressure of inhaling chock plug 2, so less on inhaling plug impact, beat plug axle 1 and move downwards, plug 5 is loaded into glass bottle 7, plays the rear glass bottle 7 of plug and goes out to beat plug machine;

Through above-mentioned steps, the interior residual oxygen < 2% of glass bottle 7, top plug success ratio > 99%.

Claims (1)

1. amino acid injection fills nitrogen and beats a blocking method, it is characterized in that comprising the following steps:

Glass bottle fills in advance nitrogen before entering dozen plug machine, and glass bottle enters work chamber by location driver plate, and chamber fills nitrogen in advance, and nitrogen pressure is 0.2-0.3 MPa, and the time is 4 seconds;

Enter completely after cavity seal, reduce nitrogen pressure and continue inflated with nitrogen to 0.1MPa, the time is 1.5 seconds;

Vacuumize, pressure is-0.03MPa that the time is 0.5 second;

Suction obturator valve stroke is opened, and inhales plug, and pressure is-0.06MPa also to vacuumizing in glass bottle, to play the rear glass bottle of plug and go out to beat plug machine when suction obturator valve is opened;

Through above-mentioned steps, residual oxygen < 2% in glass bottle, top plug success ratio > 99%.