CN101797400A - Porous degradable magnesium alloy bone scaffold material containing HA nano-powder - Google Patents
Porous degradable magnesium alloy bone scaffold material containing HA nano-powder Download PDFInfo
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- CN101797400A CN101797400A CN201010143923A CN201010143923A CN101797400A CN 101797400 A CN101797400 A CN 101797400A CN 201010143923 A CN201010143923 A CN 201010143923A CN 201010143923 A CN201010143923 A CN 201010143923A CN 101797400 A CN101797400 A CN 101797400A
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- bone scaffold
- alloy bone
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- 239000000463 material Substances 0.000 title claims abstract description 76
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 49
- 229910000861 Mg alloy Inorganic materials 0.000 title claims abstract description 46
- 239000011858 nanopowder Substances 0.000 title claims abstract description 44
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000000843 powder Substances 0.000 claims abstract description 14
- 238000005245 sintering Methods 0.000 claims abstract description 11
- 229910001297 Zn alloy Inorganic materials 0.000 claims abstract description 10
- 239000004202 carbamide Substances 0.000 claims abstract description 10
- PGTXKIZLOWULDJ-UHFFFAOYSA-N [Mg].[Zn] Chemical compound [Mg].[Zn] PGTXKIZLOWULDJ-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 9
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 9
- 239000011701 zinc Substances 0.000 claims abstract description 9
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims abstract description 5
- 238000002360 preparation method Methods 0.000 claims abstract description 4
- 239000011148 porous material Substances 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 12
- 238000000227 grinding Methods 0.000 claims description 10
- 238000007873 sieving Methods 0.000 claims description 10
- 235000013877 carbamide Nutrition 0.000 claims description 9
- 239000013078 crystal Substances 0.000 claims description 6
- 238000000498 ball milling Methods 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 238000012856 packing Methods 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract description 8
- 229910052725 zinc Inorganic materials 0.000 abstract description 8
- 238000004663 powder metallurgy Methods 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 210000002449 bone cell Anatomy 0.000 abstract 1
- CGMRCMMOCQYHAD-UHFFFAOYSA-J dicalcium hydroxide phosphate Chemical group [OH-].[Ca++].[Ca++].[O-]P([O-])([O-])=O CGMRCMMOCQYHAD-UHFFFAOYSA-J 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 3
- 230000007547 defect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 210000004409 osteocyte Anatomy 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
- 238000005275 alloying Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 239000003519 biomedical and dental material Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000002407 tissue scaffold Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Abstract
The invention discloses a porous degradable magnesium alloy bone scaffold material containing HA nano-powder, which comprises magnesium powder added with trace refined zinc crystalline grains, HA nano-powder and pore-forming agent, wherein magnesium-zinc alloy powder has the weight percent of 50-80%, the HA nano-powder has the weight percent of 10-20% and the pore-forming agent has the weight percent of 10-30%. In the porous degradable magnesium alloy bone scaffold material containing the HA nano-powder, the HA nano-powder is hydroxylapatite, and the pore-forming agent is urea. The invention also discloses a preparation method of the porous degradable magnesium alloy bone scaffold material containing the HA nano-powder, comprising the steps of: adding the trace refined zinc crystalline grains into the magnesium alloy bone scaffold material, and then adding the nano-powder hydroxylapatite and the pore-forming agent; and obtaining the porous degradable magnesium alloy bone scaffold material by powder metallurgy sintering. The material is beneficial to growing in of new bones and proliferation of bone cells; meanwhile, as the zinc alloy and the HA nano-powder hydroxylapatite are added into the material, strength and the plastic deformation capability of a medical degradable magnesium alloy bone scaffold are improved, and the problem of application of degradable magnesium alloy in the medical field can be solved.
Description
Technical field
The invention belongs to technical field of biological materials, relate to a kind of structure that is applicable to the bio-medical material of improvement, be specifically related to a kind of HA of containing nano powder porous degradable magnesium alloy bone scaffold material.
Background technology
In the recovery and treatment of modern medicine technical field organizational structure, along with the research and the progress of biodegradable magnesium alloy bone holder material, this new biodegradable magnesium alloy bone holder material little by little is applied in aspects such as clinical medicine sustained release, fracture fixation device, skeleton defect repair and biological human organ reproduce.Because the development of this biodegradable magnesium alloy bone holder material is in the starting stage, so also have many defectives in using, not high such as the tissue scaffold design strength of materials, the implantation that is not suitable as load-bearing bone is replaced and is repaired; The medical degradable magnesium alloy bone holder material that existing employing magnesium alloy is made, after adding other alloying element, its percentage elongation is lower, can not satisfy requirement as bone support plastic working molding, obviously improve the intensity and the plastic deformation ability of medical degradable magnesium alloy bone holder material, be exploitation biodegradable magnesium alloy bone support, satisfy its serviceability and require the necessary major issue that solves.
Summary of the invention
The purpose of this invention is to provide a kind of HA of containing nano powder porous degradable magnesium alloy bone scaffold material, in magnesium alloy bone scaffold material, add micro-refinement zinc crystal grain, and adding HA nano powder hydroxyapatite and pore former material, adopt the powder metallurgy sintered new material that obtains to improve intensity and plastic deformation ability, solved the problem that exists in the existing biodegradable magnesium alloy bone holder material medical domain application technology as medical degradable magnesium alloy bone support.
The technical solution adopted in the present invention is, a kind of HA nano powder porous degradable magnesium alloy bone scaffold material that contains, described porous degradable magnesium alloy bone scaffold material be by the magnesium powder, the HA nano powder that add micro-refinement zinc crystal grain, and pore creating material forms,
Wherein, the magnesium-zinc alloy powder is 50～80%, and the HA nano powder is 10～20%, and pore creating material is 10～30%.
Porous degradable magnesium alloy bone scaffold material of the present invention, its feature also be,
Described ball HA nano powder is a hydroxyapatite, and described pore creating material is a carbamide.
A kind of preparation method that contains HA nano powder porous degradable magnesium alloy bone scaffold material of the present invention may further comprise the steps:
Step 1: at first pore creating material carbamide is carried out crushing grinding in ball mill, the ball mill revolution is controlled to be 80 rev/mins, ratio of grinding media to material 1: 10, and sphere diameter is 5mm, and the ball milling time is 1～2 hour, and sieving out particle diameter then is the granule of 100 μ m～500 μ m;
Step 2: 50～80% magnesium-zinc alloy powder that account for that will configure account for 10～30% pore creating material with sieving out, and account for 10～20% HA nano powder and fully mix;
Step 3: the dusty material of the mix homogeneously mould of packing into is adopted the powder metallurgical sintering process sintering, obtain containing HA nano powder porous degradable magnesium alloy bone scaffold material after the cooling.
The present invention contains HA nano powder porous degradable magnesium alloy bone scaffold material, by in magnesium alloy bone scaffold material, adding micro-refinement zinc crystal grain, and adding HA nano powder hydroxyapatite and pore former material, adopt powder metallurgy sintered obtaining, this new material has obtained appropriate porosity and pore size, suitable aperture helps growing into of new stock for growing into of osseous tissue provides ideal place, is beneficial to the propagation procreation of osteocyte; The adding of kirsite and HA nano powder hydroxyapatite has simultaneously improved intensity and the plastic deformation ability as medical degradable magnesium alloy bone support, has solved the problem that exists in the existing biodegradable magnesium alloy bone holder material medical domain application.
The specific embodiment
The present invention is described in detail with the specific embodiment in conjunction with the accompanying drawings.
A kind of HA nano powder porous degradable magnesium alloy bone scaffold material that contains, described porous degradable magnesium alloy bone scaffold material are by the magnesium powder, the HA nano powder that add micro-refinement zinc crystal grain, and the pore creating material composition,
Wherein, the magnesium-zinc alloy powder is 50～80%, and the HA nano powder is 10～20%, and pore creating material is 10～30%.
Ball HA nano powder of the present invention is a hydroxyapatite, and described pore creating material is a carbamide.
The present invention contains the preparation method of HA nano powder porous degradable magnesium alloy bone scaffold material, may further comprise the steps:
Step 1: at first pore creating material carbamide is carried out crushing grinding in ball mill, the ball mill revolution is controlled to be 80 rev/mins, ratio of grinding media to material 1: 10, and sphere diameter is 5mm, and the ball milling time is 1～2 hour, and sieving out particle diameter then is the granule of 100 μ m～500 μ m;
Step 2: 50～80% magnesium-zinc alloy powder that account for that will configure account for 10～30% pore creating material with sieving out, and account for 10～20% HA nano powder and fill to stir and divide a mix homogeneously;
Step 3: the dusty material of the mix homogeneously mould of packing into is adopted the powder metallurgical sintering process sintering, obtain containing HA nano powder porous degradable magnesium alloy bone scaffold material after the cooling.
Embodiment
Embodiment 1
Step 1: at first pore creating material carbamide is carried out crushing grinding in ball mill, the ball mill revolution is controlled to be 80 rev/mins, ratio of grinding media to material 1: 10, and sphere diameter is 5mm, and the ball milling time is 1 hour, and sieving out particle diameter then is the granule of 100 μ m～500 μ m;
Step 2: the 60% magnesium-zinc alloy powder that accounts for that will configure accounts for 20% pore creating material with sieving out, and accounts for 20% HA nano powder and fully mix;
Step 3: the dusty material of the mix homogeneously mould of packing into is adopted the powder metallurgical sintering process sintering, obtain containing HA nano powder porous degradable magnesium alloy bone scaffold material after the cooling.
Embodiment 2
Step 1: at first pore creating material carbamide is carried out crushing grinding in ball mill, the ball mill revolution is controlled to be 80 rev/mins, ratio of grinding media to material 1: 10, and sphere diameter is 5mm, and the ball milling time is 2 hours, and sieving out particle diameter then is the granule of 100 μ m～500 μ m;
Step 2: the 80% magnesium-zinc alloy powder that accounts for that will configure accounts for 10% pore creating material with sieving out, and accounts for 10% HA nano powder and fully mix;
Step 3: the dusty material of the mix homogeneously mould of packing into is adopted the powder metallurgical sintering process sintering, obtain containing HA nano powder porous degradable magnesium alloy bone scaffold material after the cooling.
The present invention contains the porous degradable magnesium alloy bone scaffold material of HA nano powder, by the micro-refinement zinc crystal grain of adding in magnesium alloy bone scaffold material, and adds HA nano powder hydroxyapatite and pore former material, adopts powder metallurgy sintered obtaining.The present invention selects for use carbamide as pore former material, be characterized in utilizing it at room temperature to be difficult for decomposing, decompose and do not react and be suitable in the heating process with other of bone support, decompose back noresidue in magnesium alloy substrate, sizeable porosity and aperture can be provided, help growing into of new bone, also be beneficial to the propagation procreation of osteocyte; In magnesium powder, add zinc and HA nano powder hydroxyapatite powder simultaneously, intensity and plastic deformation ability have been improved as medical degradable magnesium alloy bone support, solved in the recovery and treatment of medical domain organizational structure, along with the research and the progress of biodegradable magnesium alloy bone holder material, the problem of being used widely gradually especially at aspects such as clinical medicine sustained release, fracture fixation device, skeleton defect repair and biological human organ reproduce.
Above-mentioned embodiment is two examples of the present invention, is not to be used for limiting enforcement of the present invention and interest field, and all equivalences of making according to the described content of the present patent application scope of patent protection change and modify, and all should be included in the present patent application claim.
Claims (3)
1. one kind contains HA nano powder porous degradable magnesium alloy bone scaffold material, it is characterized in that, described porous degradable magnesium alloy bone scaffold material is by the magnesium powder, the HA nano powder that add micro-refinement Zn crystal grain, and the pore creating material composition,
Wherein, the magnesium-zinc alloy powder is 50～80%, and the HA nano powder is 10～20%, and pore creating material is 10～30%.
2. porous degradable magnesium alloy bone scaffold material according to claim 1 is characterized in that, described ball HA nano powder is a hydroxyapatite, and described pore creating material is a carbamide.
3. the preparation method that contains HA nano powder porous degradable magnesium alloy bone scaffold material according to claim 1 may further comprise the steps:
Step 1: at first pore creating material carbamide is carried out crushing grinding in ball mill, the ball mill revolution is controlled to be 80 rev/mins, ratio of grinding media to material 1: 10, and sphere diameter is 5mm, and the ball milling time is 1～2 hour, and sieving out particle diameter then is the granule of 100 μ m～500 μ m;
Step 2: 50～80% magnesium-zinc alloy powder that account for that will configure account for 10～30% pore creating material with sieving out, and account for 10～20% HA nano powder and fully mix;
Step 3: the dusty material of the mix homogeneously mould of packing into is adopted the powder metallurgical sintering process sintering, obtain containing HA nano powder porous degradable magnesium alloy bone scaffold material after the cooling.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010143923A CN101797400A (en) | 2010-04-12 | 2010-04-12 | Porous degradable magnesium alloy bone scaffold material containing HA nano-powder |
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| CN201010143923A CN101797400A (en) | 2010-04-12 | 2010-04-12 | Porous degradable magnesium alloy bone scaffold material containing HA nano-powder |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599561A (en) * | 2013-11-07 | 2014-02-26 | 同济大学 | Preparation method of magnesium alloy/hydroxyapatite composite |
| CN103826668A (en) * | 2011-09-06 | 2014-05-28 | 斯特里克斯股份公司 | Method for producing a medical implant from a magnesium alloy |
| CN108971498A (en) * | 2018-08-28 | 2018-12-11 | 佛山市宝粤美科技有限公司 | A kind of production method of powdered metal frame |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103826668A (en) * | 2011-09-06 | 2014-05-28 | 斯特里克斯股份公司 | Method for producing a medical implant from a magnesium alloy |
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| CN108971498A (en) * | 2018-08-28 | 2018-12-11 | 佛山市宝粤美科技有限公司 | A kind of production method of powdered metal frame |
| CN108971498B (en) * | 2018-08-28 | 2020-11-03 | 徐州融创达电子科技有限公司 | Manufacturing method of powder metallurgy metal frame |
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Application publication date: 20100811 |