CN101795665A

CN101795665A - Method of regulating hair growth

Info

Publication number: CN101795665A
Application number: CN200880024981A
Authority: CN
Inventors: J·E·奥布隆
Original assignee: Procter and Gamble Ltd
Current assignee: Procter and Gamble Ltd; Procter and Gamble Co
Priority date: 2007-07-18
Filing date: 2008-07-15
Publication date: 2010-08-04
Also published as: WO2009010921A2; EP2164457A2; WO2009010921A3

Abstract

Method for regulating hair growth, comprising the steps of applying a composition to keratinous tissue comprising the hair in need of regulation, said composition comprising at least one PARP-1 inhibiting compound; and delivering energy to the keratinous tissue by means of an energy delivery device.

Description

Regulate the method for hair growth

Invention field

The present invention relates to be used to regulate the method for hair growth, described method comprises the following steps: that needing the collenchyme of the hair of adjusting to use to formation comprises one or more poly-(ADP-ribose) polymerases-1 inhibition compound compositions, and to described collenchyme delivery of energy.

Background of invention

Usually need regulate hair growth and improve area of personal appearance and health.Proposed several different methods and personal care product and removed unnecessary hair, for example shaving, electrolysis, wax defeathering and depilatory cream.Yet these methods have some shortcomings.Shaving only can provide the hair removing of short-term and must carry out repeatedly.The electrolysis and the defeathering of waxing can make the zone of handling not have hair in very long a period of time, but expensive and/or painful.Therefore, need to propose the method for scalable hair growth.Described method can reduce or eliminate the needs that carry out hair removing repeatedly, and can reduce or eliminate thing followed shortcoming.

Can use energy delivery apparatus such as laser instrument, diode laser and flash lamp to regulate hair growth.Traditionally, these devices are expensive, heavy and only are suitable for professional's use.In addition, these devices can cause worthless damage to parafollicular cell and tissue.The development of less handheld energy delivery apparatus has overcome wherein numerous shortcomings, yet less device can cause the shortening that efficient reduces and hair removing is held time.In addition, hair follicle is execution reparation process to the reaction of energy effect, and described process will be recovered the damage that energy brings out fast enough, become obvious and can not make any hair growth suppress effect.Therefore there be the method for requirement that continues, especially with the combined method of energy discharger to provide more effective and to regulate the superfluous hairs growth efficiently.

Summary of the invention

The present invention has satisfied above-mentioned requirements by the processing scheme that compositions, its using method is provided and is used to regulate hair growth.The applicant believes, by use the chemical compound that can be used for suppressing poly-(ADP-ribose) polymerase-1 activity (PARP-1) to collenchyme, delivery of energy simultaneously or subsequently can realize that more effective hair growth regulates.Without being limited by theory, the PARP series in the protein has shown can repair the DNA damage that occurs via number of ways, and wherein a kind of approach is to the cell delivery of energy with for example heat or radiating form.Thinking has multiple chemical compound for example nicotiamide, curcumin, 3-aminobenzamidine can suppress other member of PARP-1 and PARP series.Show that also energy can see through skin and hair safely and be delivered to the ball top zone.The applicant believes that energy is preferentially absorbed by melanocyte, is discharged into around the hair follicle zone with the heat energy form then, and wherein it makes temperature rise to such an extent that enough high causing with the pair cell component damaged and the inhibition cell proliferation.Repair process by inhibition because of the activated PARP-1 of damage response that heat energy is caused, the ability of hair follicle cell growth hair will be limited, and cause existing hair growth speed reduction and/or new piliation to produce speed and reduce.Therefore, it is believed that the combination of using PARP-1 inhibitor and energy to mammal skin, will cause hair growth to slow down and/or suppressed.Also can provide additional beneficial effect, such as the control body odor.

The applicant believes that also known other chemical compound that provides hair growth, hair outward appearance and body odor effectively to regulate can be sent to be used in combination to provide hair growth is further regulated with PARP-1 inhibitor and energy.This type of additional hair growth is regulated chemical compound and is included but not limited to primoline, pantothenylol, pantothenic acid derivative, BHT, tetrahydrocurcumin, apigenin, green tea extract and catechin compounds.

Below represented some non-limiting embodiments of the present invention.

According to first embodiment of the present invention, the method that is used to regulate hair growth is provided, described method comprises the following steps: to use compositions to the collenchyme that constitutes the hair that needs adjusting, and described compositions comprises at least a PARP-1 and suppresses chemical compound; And via the energy delivery apparatus to described collenchyme delivery of energy.

According to another embodiment of the invention, the method that is used to regulate hair growth is provided, described method comprises the following steps: oral at least a PARP-1 inhibition chemical compound and the oral compositions of accepting carrier of comprising; And the collenchyme delivery of energy that needs the hair of adjusting via the energy delivery apparatus to formation.

According to another embodiment of the invention, the cover box that is used to regulate hair growth is provided, described cover box comprises that containing one or more PARP-1 suppresses compound compositions; With the energy delivery apparatus.

According to another embodiment of the invention, the embodiment that is used to regulate hair growth is provided, described scheme comprises the very first time at interval, during this period energy is delivered to the collenchyme zone of the hair that formation need regulate; Second interval, delivery of energy not during this period; With the 3rd interval, will comprise one or more PARP-1 inhibition compound compositions during this period and be administered on the described collenchyme zone.

Detailed Description Of The Invention

The invention describes the method that is used to regulate hair growth, described method comprises the following steps: to use to the collenchyme of the hair of constitute to need regulating and comprises one or more PARP-1 and suppress compound compositions, and via the energy delivery apparatus to described collenchyme delivery of energy.Beneficial effect includes but not limited to adjusting hair growth as described herein, the control body odor, regulate skin appearance and/or hair outward appearance, reduce the shaving frequency, improve the hair removal easiness, improve shaving efficient, make hair become more soft thinner, make hair more not obvious, slow down hair regeneration, reduce erythema and to the stimulation of skin, reduce or eliminate the incised wound that causes owing to shaving and the risk of incised wound, keep required hair style for a long time, keep required color development for a long time, keep required beard pattern for a long time, reduce the aperture outward appearance, and above-mentioned combination.

The energy delivery apparatus can be sent the energy of various ways, includes but not limited to luminous energy, heat energy, acoustic energy (comprising ultrasound wave), electric energy, magnetic energy, electromagnetic energy (comprising rf wave and microwave) and their combination.Luminous energy can be sent by some device, and described device includes but not limited to laser instrument, diode laser, diode laser bar, diode laser array, flash lamp, intense pulsed light (IPL) source and their combination.Described energy delivery apparatus can randomly comprise and being used for before energy is sent, simultaneously or heat and/or cool off the device of skin afterwards, and can comprise the device that is used for storage composition and sends one or more compositionss by described device.In one embodiment, described device is a hand-held.In another embodiment, described device is a wireless type.

Comprise one or more PARP-1 inhibition compound compositions and can adopt multiple final form, its limiting examples comprises lotion, cream, liquid, gel, emulsion, multi-phase emulsion and solid form.Optional at least a additional hair growth adjusting chemical compound and at least a additional skin care actives that is used to regulate condition of mammalian skin of comprising of compositions of the present invention.

This paper has described above-mentioned each composition and supplementary element.

In all embodiments of the present invention, unless specify in addition, all percentage ratios are all by the weight of described total composition.Unless specify that in addition all ratios is weight rate.All scopes be comprise boundary and can merge.The number of significant digits is neither represented indicated quantitative limitation, does not also represent the restriction to measurement precision.Unless specify that in addition all numerical value are interpreted as being modified by speech " pact ".All are measured and all to be understood that to carry out under 25 ℃ and environmental condition, and wherein " environmental condition " is meant the condition under an about atmospheric pressure and about 50% relative humidity.Except as otherwise noted, all above-mentioned weight relevant with ingredients listed are all based on content of active substance, and do not comprise the carrier or the by-product that may be included in the commercially available acquisition material.All used relational languages related with regulating hair growth and other beneficial effect (such as softer, thinner, reduce, more not obvious, thinner etc.) be interpreted as being meant, observed beneficial effect be with do not use compositions situation described herein under the comparing of viewed or expection.

Herein, " energy delivery apparatus " is meant any device that is used for to skin, hair and other collenchyme delivery of energy.Herein, " energy is sent " is to instigate the collenchyme surface to contact with the energy of being launched by the energy delivery apparatus, and wherein it is penetrable to required organized layer, comprises hair shaft and/or hair follicle.

Herein, " energy " includes but not limited to the energy of following form: luminous energy, heat energy, acoustic energy (comprising ultrasound wave), electric energy, magnetic energy, electromagnetic energy (comprising rf wave and microwave) and their combination.

Herein, " constant level " is meant between device start-up time and device down time, on the level that energy that device is sent or energy output remain on substantial constant.

Herein, " pulse " be meant the device start-up time and the device down time between.The variation of energy output estimating is characterized in that the higher output period (pulse) and the low output period alternately takes place.The generation typical case of pulse is moment rather than progressive." can estimate " to be meant that the interval between pulse peak intensity, pulse shape, pulse duration and the pulse is identical basically.Time between pulse duration and the pulse can be at big approximate number femtosecond (or 10-15 second) to the several seconds scope.

Herein, " modulation system " of sending related use with energy is meant between device start-up time and device down time, energy output is characterised in that higher output period (pulse) and low alternately generation of output period, and wherein the interval between pulse strength, pulse shape, pulse duration and the pulse is significantly different.Change and depend on service condition, for example thickness of skin, hair density, chromotrichia, hair thickness etc.Time between pulse duration and the pulse can be in about 1/10th seconds to tens seconds scopes.

Herein, " the non-modulation formula " of sending related use with energy is meant between device start-up time and device down time, the energy output substantially constant, but can reduce or disappear in some cases.When energy output reduced or disappear, described device kept starting.The situation typical case who influences energy output is directly controlled by the operator, but the result that parameter caused in the device is imported or be built into to program.These situations can include but not limited to that device does not contact with skin, or the indication of device feedback, specify skin area processed.

Phrase used herein " with the large stretch of skin area of quick hair growth technical finesse " comprises shaving, pull off the feather of, make the skin defeathering etc. that contacts, waxes with depilatory.

" simultaneously " used herein be to point to the dermal administration compositions and be the part of single continuous action basically to the dermal delivery energy, or alternatively extremely short to dermal administration compositions and the elapsed time between the dermal delivery energy.Herein, " extremely short " should be understood to include about five minutes or shorter.The embodiment of extremely short elapsed time comprises to the skin area of needs coating and uses compositions, do not having other remarkable required time of delivery of energy under situation of delay thereafter.

" order " used herein or " in order " are meant before the dermal delivery energy and/or afterwards to the dermal administration compositions.Herein, " before " be meant at first to specifying skin area to carry out the local application of compositions, subsequently with period of at least five minutes, and alternatively subsequently with period of at least ten minutes, do not carry out sending of energy during this period, subsequently with during this period to period of the suitable delivery of energy of skin area of using compositions to skin.Herein, " afterwards " be to point to suitably delivery of energy of specified skin area, subsequently with period of at least five minutes, and alternatively subsequently with period of at least ten minutes, do not carry out sending of energy during this period, use compositions to the same substantially skin area that applies energy subsequently to skin.

Should be appreciated that " in order " comprises alternately the application program to dermal administration compositions and delivery of energy.The ratio that compositions application times and energy are sent number of times can change in the larger context, and in those skilled in the art's the determination range.For example, can be repeatedly and use compositions regularly, less to the dermal delivery energy.An embodiment who uses in order is such application program, wherein with every day or be weekly that benchmark is used compositions repeatedly, and is that benchmark carries out sending of energy with every month.

Herein, " coverage indicator " is to point to any parts that user indication energy has been applied to the collenchyme zone.Indication can be the response that is stimulated producing by for example change color, chemical change, energy level variation, variations in temperature etc.The embodiment of indicator includes but not limited to comprise the compositions of color indicator, the electronic sensor that can launch sound or visual signal or their any combination.

Herein, used " hand-held " that relates to the energy delivery apparatus is that finger device has weight and the size that is fit to general adult's comfortable grip.

" collenchyme " used herein is meant containing horny layer and comprising the skin that contains hair as mammal outermost layer guard cover." skin " used herein is meant all layers of skin, comprises epidermal area, skin corium and hypodermic layer.

" dermatological is acceptable " used herein is meant that described compositions or its component are applicable to mammalian keratinous tissue and contacts, and do not have unsuitable toxicity, incompatibility, unstability, atopic reaction etc., and compatible, and can not cause unsuitable safety or toxicity problem with active substance of the present invention and energy delivery apparatus.

Herein, " PARP-1 suppresses chemical compound " is meant with respect to observed activity, content and/or expression under the similar controlled condition that does not wherein have PARP-1 inhibition chemical compound basically, can reduces, suppress, weaken, postpone, weaken and/or reduce the chemical compound of PARP-1 enzyme activity level, zymoprotein content and/or gene expression.

Be to be understood that, PARP-1 suppress chemical compound can to skin and/or collenchyme provide other directly or indirectly because of hair growth regulate produces or regulate the beneficial effect that has nothing to do with hair growth, for example, improve skin appearance, for example, make skin youth again, reduce microgroove, wrinkle, pore and increase, make skin glossy etc.; Improve dermal sensation; Regulate chronic skin disease,, alleviate dandruff conditions and regulate body odor as acne and seborrheic dermatitis.

Herein, the method that " adjusting hair growth " should be understood to include minimizing, regulates, suppresses, weakens, postpones and/or slow down hair growth, and comprise adjusting hair outward appearance, comprise that the desired time keeps required hair style more of a specified durationly under the compositions situation of the present invention than not using.By the adjusting that reduces the hair removing frequency or show hair growth by sense of touch and/or visually-perceptible to the hair minimizing.

Herein, " hair growth adjusting chemical compound " is meant the chemical compound that is used to regulate hair growth, and is interpreted as not comprising the chemical compound such as depilatory.As used herein, " hair " comprises the hair on any position of health, and is unnecessary hair specifically.

" regulate hair outward appearance " used herein is meant that the hair on the perception skin visually is soft more, more very thin or more not obvious.In addition, people may notice that simplicity, frequency and the efficient of hair removal increase.Can show slowing down and/or suppressing of hair growth qualitative or quantitatively.Hair growth slows down and/or the qualitative sign that suppresses comprises the perception of people to for example soft more, more very thin or more inconspicuous hair.Hair growth slows down and/or the quantitatively characterizing that suppresses comprises when the hair amount of for example removing by shaving reduces.

Herein, " body odor " is meant minimizing, suppresses, weakens, shelters or eliminates by what body of mammals gave out and make us unhappy or disgusting abnormal smells from the patient.

As used herein, " derivant " includes but not limited to amide, ether, ester, amino, carboxyl, acetyl group and/or the 01 derivatives of appointed compound.

As used herein, " isomer " should be understood to include D-isomer, L-isomer and/or the DL-isomer of appointed compound.

As used herein, " salt " includes but not limited to sodium salt, potassium salt, calcium salt, ammonium salt, manganese salt, mantoquita and/or the magnesium salt of appointed compound.

Herein, " dietary supplement " is meant the oral acceptable diet composition that is intended to replenish diet.Its non-limiting example comprises, vitamin, mineral, herbaceous plant or other plant, aminoacid, enzyme and metabolite.Should be appreciated that " dietary supplement " comprise can oral absorption nicotiamide, α-and/or beta glucan, form that wherein can oral absorption comprises than the higher glucosan of contained glucosan concentration in the primary or natural materials that produces glucosan.The form that has wherein applied dietary supplement can change in the larger context, and comprises for example tablet, capsule, gel tablet and liquid, and can be incorporated in the Foods or drinks.

I. compositions

A.PARP-1 suppresses chemical compound

Compositions of the present invention comprises about 0.0001% to about 20%, and preferred about 0.001% to about 10%, and more preferably from about 0.01% to about 5% at least a PARP-1 suppresses chemical compound.The limiting examples that suitable PARP-1 suppresses chemical compound comprises salt and the derivant and their mixture of nicotinic acid and ester, nicotiamide ester, phenyl benzimidazole, Phenylbenzimidazolesulfonic acid, 3-acetylamino Benzoylamide, benzenecarboximidamide, 3-aminobenzene carbonamidine, above-mentioned any material.

B. hair growth is regulated chemical compound

Topical compositions of the present invention can comprise about 0.0001% to about 20%; preferred about 0.001% to about 10%; and more preferably from about 0.01% to about 5% at least a hair growth is regulated chemical compound; described chemical compound is selected from the group of being made up of following: Yoshinox BHT; butylated hydroxyanisol; cetylpyridinium chloride; the primoline chemical compound; plant sterol is (such as sitosterol; stigmasterol; campesterol; campesterol; kinetins and zeatin); the green tea catechins chemical compound is (such as epicatechin; L-Epicatechin gallate and epigallocatechin gallate (EGCG)); salicylic acid; carbamide; maloic acid; Er Fujiajiniaoansuan; the Alpha-Methyl ornithine; 1; the 8-octamethylenediamine; bathocuproine; alanopsin; arginine; extract derived from bean plant; cinnamic acid; the ortho-aminobenzoic acid cinnamic ester; mannosamine; GLYCERYL DILAURATE (comprises that derivant is such as α; α-dilaurin and 1; 2-two Laurels acyl group-SN-glycerol); versulin; caryophyllin; Azelaic Acid; Sulforaphane; canavanine; the pyridoxal 5-phosphate ester; phytic acid; tannic acid; Semen Vitis viniferae extract; NG-nitro-L-arginine methyl ester (L-NAME); benzenecarboximidamide; sodium butyrate; belulinic acid Betulinic acid; polyornithine; poly arginine; fisetin; methyl jasmonate; cis-jasmone; CAPE; delphinidin; ethyl abietate; esculetin; the sorbic acid methyl ester; the L-canaline; the N-formyl methionine; N-formyl alanine; taurine; palmitoyl carnitine; undecyl alcohol; 9-undecylenic acid; rutin; fusidinic acid; phenylpyruvic acid; the L-isoleucine; phenylglycine; silymarin; silymarin; L-ascorbic acid-6-cetylate; N-endecatylene acyl-L-phenylalanine, and the salt of above-mentioned any material; derivant and mixture.

C. chronic skin care actives

Compositions of the present invention can comprise about 0.001% to about 10%, preferred about 0.01% to about 5%, and 0.1% to about 1% at least a chronic skin care actives more preferably from about, described material can be used for providing at least a additional beneficial effect to mammalian keratinous tissue, includes but not limited to reduce wrinkle, dark stricture of vagina, microgroove, crack, lump, thick appearance of pores; Increasing corium-epidermis border circles round; Blast skin; Increase elasticity, reduce sagging, reduce liparitosis; Reduce the black eye outward appearance, reduce the variable color outward appearance, reduce hyperpigmentation; Increase skin gloss, and their combination.The limiting examples of suitable chronic skin care actives comprises that polyacrylamide/C13-14 isoparaffin/laureth-7 (can trade name Sepigel ^TM305 is commercially available); the N-acetyl glucosamine; polyacrylamide/C13-14 isoparaffin/laureth-7; carnosine; vitamin e acetate; N-acetyl group-D-glycosamine; the glucityl hesperidin; the ascorbyl glucoside; palmityl-lysine-threonine-threonine-lysine-serine; palmityl-lysine-threonine; cetyl betaine; bisabolol; theophylline; dihydroxy acetone; pantothenylol; PAROSOL 1789; glycyrrhizic acid; enoxolone; ergothioneine; octadecene diacid; Vitamin A propionate; yeast extract, and the salt of above-mentioned any material; derivant and mixture.

D. optional skin care actives

Compositions of the present invention can comprise at least a additional skin care actives to be used for regulating and/or improving condition of mammalian skin.The limiting examples of suitable skin care actives is described in the U.S. Patent application of submitting on June 30th, 2,006 60/818,152 and U.S. Patent application 2007/0065381A1.In one embodiment, described additional skin care actives comprises about 0.0001% to about 20%, preferred about 0.001% to about 10%, and more preferably from about 0.01% to about 5% at least a additional hair growth is regulated chemical compound, described chemical compound is selected from the group of being made up of following: wortmannin, reduce the chemical compound of Cadherin-11 and TRPS1, the Bowman-Birk protease inhibitor, skelemin and anti-VEGF (VEGF) peptide, TRPV3 (ion channel transient receptor potential V3) antagonist, protein arginine methylferase inhibitor, palmatine, Flos Chrysanthemi petal extract and Radix Arctii seed extract, with human body desmoglein-4 or do not have that to modify mRNA be the RNAi of object, Radix Sophorae Flavescentis extract, Flos Sophorae Immaturus extract, leucojum aestivum, Radix Ginseng extract, pineapple extract, bent juice, the Fructus Rosae Davuricae extract, Fructus Pruni extract, Fructus actinidiae chinensis extract, angiopoietin-like april protein antagonist, Borax, derive from the cytotoxin agglutinin, ricin, the toxicity albumin of abrin and modeccin, malonic acid, malic acid, arm plate albumen 3B regulator, equol, Herba Urticae Cannabinae, geldanamycin, P material, and the salt of above-mentioned any material, derivant and combination.Described additional hair growth is regulated chemical compound and is preferably selected from the group of being made up of following: wortmannin, palmatine, malonic acid, malic acid, equol, geldanamycin, and the salt of above-mentioned any material, derivant and combination.

E. carrier

Personal care composition of the present invention can comprise suitable carrier.When described compositions was local application, described carrier was the dermatological acceptable carrier.When described compositions was oral absorption, described carrier was oral acceptable carrier.The content of described carrier counts about 50% to about 99.99%, perhaps about 60% to about 99.95%, perhaps about 70% to about 98%, perhaps about 80% to about 95% by the weight of described compositions.

The dermatological acceptable carrier can be taked various ways.The non-limiting example that can be used for emulsion of the present invention comprises O/w emulsion, water-in-oil emulsion, water-in-silicone emulsion, water-covered siloxane emulsion, water-in-oil-in-water compositions and water-in-silicone bag fat liquor.Alternatively, described emulsion is an O/w emulsion.Emulsion also can comprise wetting agent such as glycerol, and can comprise about 1% to about 10%, perhaps about 2% to about 5% nonionic, anion or cationic emulsifier.The case description of water-in-silicone emulsion and O/w emulsion is in the United States Patent (USP) 6,238,678 of authorizing people such as Oblong.

F. optional member

1. deodorizer

Compositions of the present invention can comprise deodorizer.The chemical compound that is suitable for regulating stench but does not provide remarkable hair growth to regulate is provided " deodorizer " used herein.The non-limiting example of deodorizer is present in the compounds that comprises cyclodextrin.Term used herein " cyclodextrin " (CD) comprises any known cyclodextrin, as can with cause smelly compound formation coordination compound and comprise the unsubstituted ring dextrin of six to 12 glucose units.Suitable cyclodextrin comprise α-, β-and gamma-cyclodextrin, their salt, isomer and derivant and their mixture.Inter alia, α-, β-and gamma-cyclodextrin can derive from American Maize-Products Company (Amaizo), Corn Processing Division, Hammond, Indiana; And RoquetteCorporation, Gurnee, Illinois.Many cyclodextrin derivative are known, comprise United States Patent (USP) 3,426,011; 3,453,257; 3,453,258; 3,453,259; 3,453,260; 3,553,191; Authorize people's such as Parmerter United States Patent (USP) 3,565,887; Authorize people's such as Gramera United States Patent (USP) 3,459,731; Authorize people's such as Szejtli United States Patent (USP) 4,535,152; Authorize people's such as Hirai United States Patent (USP) 4,616,008; Authorize people's such as Brandt United States Patent (USP) 4,638,058; Authorize people's such as Tsuch i yama United States Patent (USP) 4,746,734; And authorize in people's such as Ogino the United States Patent (USP) 4,678,598 disclosed those.The example that is applicable to the cyclodextrin derivative of this paper is methyl-β-CD, hydroxyethyl-β-CD and the hydroxy propyl-Beta-CD with multiple substitution value, its can derive from Amaizo and Aldrich Chemical Company (Milwaukee, Wisconsin).Soluble derivative also is highly suitable.

Independent cyclodextrin also can by for example use the multi-functional group reagent be bonded together with form oligomer, altogether-oligomer, polymer, copolymer etc.The example of above-mentioned substance derives from Amaizo and Aldrich Chemical Compnay (β-CD/ epihalohydrin copolymer).

2. depilatory

Certain embodiments of the present invention can comprise depilatory." depilatory " used herein is meant the reagent that can remove existing hair but significantly not suppress hair regeneration and/or live again.Without being limited by theory, thus it is believed that depilatory causes hair fiber to decompose by the disulfide bond that disconnects in the hair-keratin, removes existing hair.The depilatory that can be used in the invention of this theme comprises thioglycol acid ammonium, barium sulfate, thioglycol acid calcium, thioglycol acid ethanolamine, thioglycol acid potassium, thioglycol acid sodium, TGA, thiacetic acid. and their mixture.The embodiment of suitable depilatory is described in greater detail in the United States Patent (USP) 5,897,857 of authorizing people such as Hillebrand.

3. granule

Compositions of the present invention can comprise particulate matter.The non-limiting example of suitable particulate matter is found in Gottschalck, T.E. and McEwen, Jr. the The Cosmetic that writes, Toiletry, the The InternationalCosmetic Ingredient Dictionary and Handbook the 10th edition (2004) of and Fragrance Association, the 2728th page.Other embodiment that can be used for the particulate matter among the present invention includes normal complexion leuco-pigment, coated interference pigment, except that above-mentioned inorganic powder and organic dust, composite powder, fluorescent whitening agent granule and their mixture those.Above-mentioned particulate average-size is usually less than above-mentioned particulate matter, for example about 0.1 micron to about 100 microns scope.These granules can be for example flaky, globular, elongated or acicular or erose; Surface coated or not coated; Porous or atresia; Electrically charged or uncharged; And can be used as powder or predispersion is added in the present composition.These particulate matters can be derived from natural and/or synthetic source.

II. energy

The energy of sending to collenchyme includes but not limited to the energy of following form: luminous energy, heat energy, acoustic energy (comprising ultrasound wave), electric energy, magnetic energy, electromagnetic energy (comprising the radio frequency energy) and their combination.In one embodiment, described energy is delivered in the collenchyme with the form of light, heat and ultrasound source and their combinations.In another embodiment, described energy is sent with the form of light, perhaps sends with the form of laser emission light.Described energy can be continuously, pulse, modulation, pattern non-modulation and their combinations are sent by these different sources.Alternatively, described energy right and wrong are synthetic.Suitable form of energy and energy delivery apparatus are described in WO2006/107673 and the U.S. Patent application 2006/011433, and it openly incorporates this paper into way of reference.

The energy value that is delivered on the skin is enough to cause cell injury, and such as protein denaturation and cell inhibitory effect effect, and the normal cell physiological process is upset.Hair follicle is done and the ball top regional temperature rises to the energy input scope of 45 ℃ or higher temperature.Alternatively, the energy that is delivered on the skin is enough to regulate hair growth.Hair follicle is done and the ball top regional temperature rises to the energy input scope of the temperature between 37 ℃ to 44 ℃.

In one embodiment, the energy delivery apparatus has singlehanded comfortable weight of holding of suitable general adult and size.Alternatively, the volume of described device can be 1500 cubic centimetres (ccm) or littler, and perhaps described volume is less than 1000ccm, and perhaps described volume is less than 750ccm.The weight of described device alternatively is 1 kilogram (kg) or lighter, perhaps less than 750 grams, perhaps less than 500 grams.The embodiment of suitable hand-held energy delivery apparatus is described among US 2004/0167499A1 people such as () Grove.

Described energy delivery apparatus also can comprise the parts that are used for preheating or are used to cool off skin.Referring to the United States Patent (USP) 6,273,884 of for example authorizing people such as Altshuler.In addition or alternatively, described energy delivery apparatus is wireless.

III. using method

A. application process

Can carry out using of described compositions in several ways, comprise with finger or hands, or pass through tool using.Limiting examples comprises pad, cotton balls, uses pen, spray application device, substrate and sticking patch.Described compositions can be fixed and/or be encased in the energy delivery apparatus self.In addition or alternatively, compositions of the present invention can be come oral via carrier for oral use.

Use compositions by patch, also can be used for the problem skin area that more powerfully to use.This patch can be occlusion, half occlusion or not occlusion, and can be viscosity or inviscid.Said composition can be comprised in the patch, or is administered on the skin before using patch.The chemical initiator that described patch also can comprise additional activity material such as skin conditioning agent and be used for neither endothermic nor exothermic reaction is such as the U.S. Patent Publication 5,821,250,5,981,547 and 5,972 of authorizing people such as Wu, described in 957 those.Described patch can keep on skin at least about 5 minutes, perhaps at least about 15 minutes, perhaps at least about 30 minutes, perhaps at least about 1 hour, perhaps spends the night as form of therapy reservation at night.Can or remove delivery of energy before the described patch after removing described patch.Before removing described patch during delivery of energy, described patch can be by being of value to the material of delivery of energy form make.

Can in bigger number change scope, use compositions of the present invention to improve skin.Alternatively, Shi Yi amount of application is about 0.1mg/cm ²To about 20mg/cm ²An available amount of application is about 0.5mg/cm ²To about 10mg/cm ²Alternatively, described compositions is delivered to face and/or cervical region.

B. to the dermal delivery energy

The energy delivery apparatus can be sent the energy of various ways, includes but not limited to the energy of following form: luminous energy, heat energy, acoustic energy (comprising ultrasound wave), magnetic energy, electromagnetic energy (comprising rf wave and microwave) and their combination.Be meant via the energy of the mode that is fit to institute's delivery of energy type to the dermal delivery energy and be applied on the collenchyme effective dose.From the energy of these separate sources can be successive, pulse, synthetic, non-modulation and their combination.In one embodiment, described energy delivery apparatus is a hand-held.Alternatively, described energy delivery apparatus is wireless.

By device being maintained the single area of collenchyme, subsequently described device is moved to another zone (or punching press) of tissue, apply energy.Alternatively, can when described device moves continuously or scan by tissue surface, apply energy.Sweep speed will depend on multiple factor, and embodiment comprises the type of device size, hair amount, collenchyme and the energy values of being sent.When using laser aid, described device will keep basic Continuous Contact with the collenchyme surface, and perhaps when using flash lamp, described device and collenchyme keep short distance, and energy points to the surface simultaneously.

In one embodiment, the energy output right and wrong are synthetic.Described non-modulation can the adjusting by the feedback that is received by device.This feedback is produced by the energy that is delivered in the skin, wherein in skin self or be administered in some chemical compound on the skin and change.Alternatively, the skin area that wherein changes is similar to the skin area of energy delivery apparatus delivery of energy on it dimensionally.Alternatively, the skin area that wherein changes is greater than the skin area of delivery of energy on it.

In collenchyme, or alternatively in the chemical compound on being administered to skin surface, can produce variations in temperature simultaneously.This variations in temperature is the variation except that any variations in temperature that is produced by delivery of energy self.For example, can perhaps after energy is sent, collenchyme be cooled off with the collenchyme heating before energy is sent.

For for the energy of ultraviolet source, wavelength is usually located in the UV-A scope of about 315-400nm, and wherein " nm " is meant 1 * 10 ^-9Rice.For for the energy of visible light source, wavelength usually at about 400nm to the scope of about 700nm.For for the energy of infrared (IR) light source, wavelength is extremely about to the scope of about 3000nm at about 700nm usually.The energy values of being sent or " output flow " can be at about 1J/cm ²To about 100J/cm ²Scope in, wherein " J " is meant joule.For light-pulse generator, pulse width about 0.001 second to about 3 seconds scope, the average pulse persistent period is about 0.001 second to about 1 second.Collenchyme surface area to be covered will change according to using.Send these and other relevant parameter with energy and depend on the type of processing and the type of pending tissue, and can come suitable selection by those skilled in the art.

C. application program

With to the dermal delivery energy simultaneously and/or in order to dermal administration compositions of the present invention.Alternatively, in delivery of energy before the described compositions of dermal administration.Alternatively, described application program can comprise the step with quick hair growth technical finesse skin.

Alternatively, can absorb the present composition of oral absorption, then to the dermal delivery energy.In one embodiment, the described compositions of orally ingestible, delivery of energy, and the optional step of handling skin with acute hair growth technical finesse that comprises then.

An example of suitable treatment scheme comprises the very first time at interval, during this period energy is delivered to the collenchyme zone of the hair that formation need regulate, second interval or rest period subsequently, delivery of energy not during this period; The 3rd interval subsequently is administered to compositions as herein described on the collenchyme zone of delivery of energy during this period.The persistent period of rest period will change according to those skilled in the art's judgement.In one embodiment, rest period continues about 30 minutes, perhaps continues about 20 minutes to about 30 minutes, perhaps continues at least 30 minutes, perhaps continues at least one day, perhaps continues at least 14 days.

Alternatively, described processing scheme can comprise very first time interval (using compositions as described herein during this period), second interval or rest period (during this period not delivery of energy) subsequently, the 3rd interval (during this period energy being applied on the collenchyme zone of applying said compositions) subsequently.

D. overlap box

The present invention also can comprise the cover box, and described cover box comprises that containing at least a PARP-1 suppresses compound compositions and energy delivery apparatus.Described cover box also comprises at least a annexing ingredient, and described component is selected from the group of being made up of following: the guidance of coverage indicator, hair removal machinery (comprising razor, depilator, operated shaving appliance, tweezers etc.), depilatory, wax, instrument, at least a additional personal care composition, dietary supplement, the guidance of deferring to processing scheme, use coverage indicator; And their combination.Described cover box can comprise independently inner packing unit, and each inner packing unit comprises a certain amount of compositions that is applicable to the single administration scheme.In one embodiment, the individual packages unit can comprise 10mL, perhaps comprises 5mL, perhaps comprises 1mL, perhaps comprises the compositions as described herein of 0.5mL.Described description can be directly or indirectly to stick to the printing material that comprises on the goods packing.Alternatively, described description can be placed near the container directly or indirectly.Alternatively, described description can be electronic information or the announcement information relevant with goods.Alternatively, described description can be described the possible purposes of at least a goods, performance, characteristics and/or restriction.

Embodiment

Below be and simultaneously and/or the continuous mutually compositions embodiment that uses to the dermal delivery energy.

Component	??M	??N	??O	??P
Component	??M	??N	??O	??P	The glycinate of alkali formula aluminum chloride zirconium (Al Zr Trichlorohydrex Glycinate) (solid)	??25	??25	??25	??25
Polydimethylsiloxane (10cs)	??5.0	??5.0	??5.0	??5.0		??25	??25	??25	??25
Polydimethylsiloxane (10cs)	??5.0	??5.0	??5.0	??5.0	Complete hydrogenant high erucic acid rape seed oil (HEAR oil)	??5.0	??5.0	??5.0	??5.0
Primoline	??0.1	??0.3	??0.1	??0.3		??5.0	??5.0	??5.0	??5.0
Primoline	??0.1	??0.3	??0.1	??0.3	3-aminobenzene carbonamidine	??3.0	??3.0	??3.0	??3.0
Nicotiamide	??5.0	??5.0	??5.0	??5.0	3-aminobenzene carbonamidine	??3.0	??3.0	??3.0	??3.0
Nicotiamide	??5.0	??5.0	??5.0	??5.0	C18-C36 acid glycerol three ester Syncrowax HGLC	??1.25	??1.25	??1.25	??1.25
Spice	??0.8	??0.8	??0.8	??0.8	C18-C36 acid glycerol three ester Syncrowax HGLC	??1.25	??1.25	??1.25	??1.25
Spice	??0.8	??0.8	??0.8	??0.8	Calcium pantothenate (solid)	??0.5	??0	??3.5	??0
??BHT	??0.5	??0.5	??0.5	??0.5	Calcium pantothenate (solid)	??0.5	??0	??3.5	??0
??BHT	??0.5	??0.5	??0.5	??0.5	Pantothenylol	??0.5	??0	??0.5	??0.5
Encircle penta siloxanes	In right amount	In right amount	In right amount	In right amount	Pantothenylol	??0.5	??0	??0.5	??0.5

Embodiment 1: via laser aid with 0.1 to 50J/cm ²The effective dose energy of scope is administered on the skin except that scalp.Will about 0.5mg/cm ²Any compositions A-L be administered on the essentially identical skin area.Observe growth rate, color and the texture of hair.If desired, handle repeatedly.

Embodiment 2: will about 0.5mg/cm ²Any compositions A-L be administered on the skin except that scalp.After 30 minutes, apply the energy of effective dose by hot delivery apparatus.If desired, carry out processing scheme repeatedly.

Embodiment 3: any compositions A-L that will about 5mg is administered on the hair on the scalp.After 5 minutes, by ultrasonic energy delivery apparatus delivery of energy.Wash described hair.If desired, carry out processing scheme repeatedly.

Embodiment 4: by heater, the skin on facial and the cervical region is preheated.Any compositions A-L of aequum is administered on the skin of facial and cervical region.In applying said compositions, by ultrasonic energy delivery apparatus delivery of energy.Described compositions is retained on the skin.

Dimension disclosed herein and value are appreciated that and strictly are limited to described exact value.On the contrary, except as otherwise noted, each such dimension is intended to represent described numerical value and centers on the scope that is equal on the function of this numerical value.For example, the dimension that is disclosed as " 40mm " is intended to expression " about 40mm ".

The All Files of quoting in detailed Description Of The Invention is all introduced for your guidance in relevant portion.Should not be interpreted as admitting that for quoting of any file it is relevant prior art of the present invention.When any implication of term in any implication of term among the present invention or definition and the file of incorporating into way of reference or when defining contradiction, should obey the implication or the definition of giving this term in the present invention.

Though illustrated and described specific embodiments of the present invention, it will be apparent to one skilled in the art that and under the situation that does not deviate from essence of the present invention and scope, can make a plurality of other changes and modification.Therefore, claims all such changes and modification of being intended to be included in the scope of the present invention.

Claims

1. method that is used to regulate hair growth said method comprising the steps of:

A) use compositions to the collenchyme that constitutes the hair that needs adjusting, described compositions comprises at least a PARP-1 and suppresses chemical compound, and wherein said PARP-1 suppresses chemical compound and is selected from the group of being made up of following: the salt of nicotinic acid and ester, nicotiamide ester, phenyl benzimidazole, Phenylbenzimidazolesulfonic acid, 3-acetylamino Benzoylamide, benzenecarboximidamide, 3-aminobenzene carbonamidine, above-mentioned any material and derivant and their mixture; Regulate chemical compound with at least a hair growth, wherein said hair growth is regulated chemical compound and is selected from the group of being made up of following: primoline, GLYCERYL DILAURATE, green tea extract and catechin, soybean protein, salicylic acid, carbamide, pantothenylol, hexanediol, apigenin and their mixture; With

B) pass through the energy delivery apparatus to described collenchyme delivery of energy, wherein said energy is the form that is selected from by the following group of forming: luminous energy, heat energy, ultrasound wave, electric energy, magnetic energy, electromagnetic energy, rf wave, microwave and their mixing.

2. the method for claim 1, wherein said energy is the luminous energy form.

3. method as claimed in claim 2, wherein said luminous energy are the luminous energy that laser produces.

4. method as claimed in claim 3, the luminous energy that wherein said laser produces is pulse.

5. method as claimed in claim 3, the luminous energy that wherein said laser produces is non-modulation system.

6. the method for claim 1, wherein said energy delivery apparatus is a hand-held, and wherein said energy delivery apparatus is wireless.

7. the method for claim 1, wherein applying said compositions and described energy simultaneously.

8. the method for claim 1, wherein applying said compositions and described energy in order.

9. the method for claim 1 wherein is delivered to described at least a additional beneficial effect on the described skin; Wherein said additional beneficial effect is the improvement of mammal skin outward appearance.

10. application program that is used to regulate hair growth, described application program comprises:

A) very first time is delivered to energy in the collenchyme zone of the hair that formation need regulate at interval during this period;

B) second interval, delivery of energy not during this period; Wherein said second interval comprises about 20 minutes to about 30 minutes; With

C) the 3rd interval will comprise one or more PARP-1 inhibition compound compositions during this period and be administered on the described collenchyme zone.