CN101766494B - Method for reusing operation parameters of high-intensity focused ultrasound equipment - Google Patents

Method for reusing operation parameters of high-intensity focused ultrasound equipment Download PDF

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CN101766494B
CN101766494B CN 200810190857 CN200810190857A CN101766494B CN 101766494 B CN101766494 B CN 101766494B CN 200810190857 CN200810190857 CN 200810190857 CN 200810190857 A CN200810190857 A CN 200810190857A CN 101766494 B CN101766494 B CN 101766494B
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patient
moving
interest
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CN101766494A (en
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吴伟刚
林佳裕
陈旸
奥利弗·施雷克
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Siemens AG
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Abstract

The invention discloses a method for reusing operation parameters of high-intensity focused ultrasound equipment. The method comprises the following steps: before a patient is moved, scanning the patient with magnetic resonance imaging equipment to obtain an image before moving; after the patient is moved, positioning a sickbed which bears the patient and scanning the patient with the magnetic resonance imaging equipment again according to scanning parameters used by the image before moving to obtain an image after moving; judging whether a position difference before and after the patient is moved is acceptable according to the image before moving and the image after moving; if the position difference is acceptable to the high-intensity focused ultrasound equipment, proceeding the operation by adopting the operation parameters before the patient is moved; and otherwise, performing the step of positioning the sickbed and the subsequent steps again. By adopting the method, after the patient is moved, the high-intensity focused ultrasound equipment can still adopt the operation parameters before the patient is moved.

Description

The method that high intensity focused ultrasound operation of equipment parameter can be used once again
Technical field
The present invention relates to high intensity focused ultrasound (HIFU) technical field of nuclear magnetic resonance (MRI) monitoring, particularly a kind of method that high intensity focused ultrasound operation of equipment parameter can be used once again.
Background technology
In high intensity focused ultrasound (the MRI guided HIFU) equipment of nuclear magnetic resonance monitoring; Usually scan by MR imaging apparatus; Obtain the image of patient's region of interest; High intensity focused ultrasound equipment image that MR imaging apparatus scanning is obtained image is as a reference operated, thereby is utilized ultrasound wave that patient is treated then.
Generally speaking, the high intensity focused ultrasound operation of equipment time is longer, can reach several hours usually.In the so long time, be difficult to let patient keep transfixion.After patient is moved, because variation has taken place for patient's position, makes high intensity focused ultrasound operation of equipment environment that variation also correspondingly take place, and can not adopt the operating parameter of patient before being moved.The new operating parameter that this just needs to confirm again high intensity focused ultrasound equipment has not only increased the useless operation of high intensity focused ultrasound equipment, but also has increased patient's waiting time.
Therefore, expectation can still can be used the operating parameter of patient before being moved by high intensity focused ultrasound equipment after patient is moved.
Summary of the invention
In view of this, the present invention proposes a kind of method that high intensity focused ultrasound operation of equipment parameter can be used once again, with so that high intensity focused ultrasound equipment still can adopt the operating parameter of patient before being moved after patient is moved.
Therefore, the invention provides a kind of method that high intensity focused ultrasound operation of equipment parameter can be used once again, this method comprises:
Before patient is moved, use patient with magnetic resonance imaging to scan, image before obtaining moving;
After patient was moved, patient's sick bed was carried in the location, according to the used sweep parameter of image before said the moving, used said patient with magnetic resonance imaging to scan once more, obtained moving the back image;
Move preceding image and move the back image according to said, judge that patient moves front-back direction difference and whether can accept, if then said high intensity focused ultrasound equipment adopts patient to move operating parameter continuation operation before; Otherwise, carry out the step and the subsequent step thereof of locating said sick bed once more.
Preferably, judge and patient move front-back direction difference whether acceptable step comprises:
Cut apart image and the area-of-interest that moves in the image of back before said move, the degree of association of area-of-interest described in the image after calculating image before said the moving and moving, judge the said degree of association whether greater than or more than or equal to a threshold value.
This method may further include: strengthen said preceding image and the edge that moves area-of-interest described in the image of back of moving, so that said cutting apart.
Preferably, use Canny operator to detect the edge of said area-of-interest.
This method may further include: the voxel size before making said mobile back image and moving in the image is identical.
Following formula is adopted in the calculating of the said degree of association:
f ( t ) = Σ p ∈ O [ I f ( p ) - I ‾ f ] [ I t ( p + t ) - I ‾ t ] { Σ p ∈ O [ I f ( p ) - I ‾ f ] 2 Σ p ∈ O [ I t ( p + t ) - I ‾ t ] 2 } 1 / 2
Wherein I ‾ f = 1 n Σ p ∈ O I f ( p ) , I ‾ t = 1 n Σ p ∈ O I t ( p ) ;
Wherein, f (t) is an image and the degree of association that moves area-of-interest in the image of back, I before moving fBe the area-of-interest in the image before moving, I tBe the area-of-interest that moves in the image of back, p is the position of moving area-of-interest in the preceding image, and t is that area-of-interest is with respect to the translation of area-of-interest in the image before moving in the image of mobile back, and n is counting of being considered among the O of overlapping region, I fAnd I tBe in the O of overlapping region, to calculate to move area-of-interest and the arithmetic average that moves the pixel value of area-of-interest in the image of back in the preceding image.
Preferably, image before said the moving being carried out down-sampling with mobile back image handles.
This method further comprises: move under the acceptable situation of front-back direction difference patient, use said mobile back image to be reference picture.
Preferably; Operating parameter before the employing patient moves continues before the operation; Calculate the said offset vector that moves between preceding image and the mobile back image; Calculate the side-play amount of the focal track of high intensity focused ultrasound equipment according to said offset vector, and be applied to the operating parameter of patient before moving.
From such scheme, can find out; Since the present invention before patient uses before and after being moved MR imaging apparatus scanning to obtain moving respectively image with move after image; Judge that according to image before moving and mobile back image patient moves front-back direction difference and whether can accept then; If then high intensity focused ultrasound equipment continues to be employed in the operating parameter that patient is moved and uses before; Thereby make the operating parameter of high intensity focused ultrasound equipment before patient is moved to use once again, avoided confirming once more required operation and the time of operating parameter, improved the service efficiency of the high intensity focused ultrasound equipment of nuclear magnetic resonance monitoring.
Description of drawings
Fig. 1 is the flow chart according to the embodiment of the invention.
The specific embodiment
For making the object of the invention, technical scheme and advantage clearer, below lift embodiment the present invention is further explained.
Core concept of the present invention is; Utilize the MRI image of patient before and after moving to judge whether patient's front-back direction difference that is moved can be accepted; If; Then high intensity focused ultrasound equipment continue to adopt the operating parameter of patient before being moved, otherwise locatees sick bed, scanogram once more and judge.
Fig. 1 is the flow chart according to the embodiment of the invention.As shown in Figure 1, the method for the embodiment of the invention may further comprise the steps:
Step 110, high intensity focused ultrasound equipment use a cover operating parameter that the patient on the sick bed is operated.
Step 120, when patient will be moved, for example patient needed activity or other reasons and motion or leave sick bed on one's sick bed once.Before patient is moved, utilize patient with magnetic resonance imaging to scan, image before obtaining moving.
The embodiment of the invention preferably scans patient by the position of high intensity focused ultrasound equipment operation, thereby obtains the image of patient body certain volume.Preferably, present embodiment scanning obtains 3D rendering.
Step 130, patient is moved, for example patient leaves sick bed, perhaps patient move on one's sick bed, rotation etc.
Step 140 after patient is moved, reapposes patient on one's sick bed, and will carry the magnet of patient's sick bed immigration MR imaging apparatus, utilizes the positioner location sick bed of MR imaging apparatus self.
Step 150 utilizes patient with magnetic resonance imaging to scan, and the sweep parameter of the scanning (that is, the scanning in the step 120) before used sweep parameter and patient are moved is identical, obtains moving the back image.
Owing to adopt identical sweep parameter, the position of being scanned before position that current scanning is scanned and patient are moved is roughly the same or approaching.
Step 160, MR imaging apparatus are cut apart mobile preceding image and are moved the back image, extract area-of-interest (ROI) respectively.The area-of-interest here for example be patient's organ, tissue etc., particularly high intensity focused ultrasound equipment the object that will operate.
In the process of segmented sense region-of-interest, mainly cut apart through the edge of area-of-interest, can adopt several different methods to detect the edge of area-of-interest, preferably, adopt Tuscany (Canny) operator to detect the edge of area-of-interest in the present embodiment.
Before extracting area-of-interest, can also strengthen the edge of area-of-interest, so that segmented sense region-of-interest better.
In addition, owing to the sampled point that moves preceding image and mobile back image that MR imaging apparatus scanning obtains is more, such image is handled to cause huge amount of calculation.In order to reduce the amount of calculation of MR imaging apparatus, present embodiment can be further to image before moving with move the back image and carry out down-sampling and handle, for example with the 256*256 down-sampling to 64*64.
Step 170 according to image before moving and the area-of-interest that moves in the image of back, judges that patient moves front-back direction difference and whether can accept, if can accept, and then execution in step 180 and subsequent step thereof, otherwise execution in step 140 and subsequent step thereof.
Present embodiment can adopt several different methods to judge that patient moves front-back direction difference and whether can accept.
Here introduce a kind of method of utilizing the degree of association of area-of-interest.The image and the degree of association that moves area-of-interest in the image of back before calculate moving, judge the said degree of association whether greater than or more than or equal to a threshold value that sets in advance.When the degree of association greater than or more than or equal to threshold value, the position of the area-of-interest before the area-of-interest that moves in the image of back being described and being moved in the image is more approaching, patient is moved front-back direction difference for accepting; Otherwise the position of the area-of-interest before the area-of-interest that moves in the image of back being described and being moved in the image differs bigger, and patient's front-back direction difference that is moved is unacceptable.
The embodiment of the invention gives a kind of method of calculating the above-mentioned degree of association, and this method adopts formula:
f ( t ) = Σ p ∈ O [ I f ( p ) - I ‾ f ] [ I t ( p + t ) - I ‾ t ] { Σ p ∈ O [ I f ( p ) - I ‾ f ] 2 Σ p ∈ O [ I t ( p + t ) - I ‾ t ] 2 } 1 / 2
Wherein, I ‾ f = 1 n Σ p ∈ O I f ( p ) , I ‾ t = 1 n Σ p ∈ O I t ( p ) .
In the equation above, f (t) is an image and the degree of association that moves area-of-interest in the image of back, I before moving fBe the area-of-interest in the image before moving, I tBe the area-of-interest that moves in the image of back, p is the position of moving area-of-interest in the preceding image, and t is that area-of-interest is with respect to the translation of area-of-interest in the image before moving in the image of mobile back, and n is counting of being considered among the O of overlapping region, I fAnd I tBe in the O of overlapping region, to calculate to move area-of-interest and the arithmetic average that moves the pixel value of area-of-interest in the image of back in the preceding image.
In addition, before patient moves with after moving, scan in the image of gained, the size of voxel (voxel) might be different.In this flow process, can further include before the compute associations degree one make move before the step that equates with voxel size in the mobile image afterwards of voxel in the image.
Step 180, high intensity focused ultrasound equipment carries out follow-up operation to move back image image as a reference.
Step 190, high intensity focused ultrasound equipment adopt the operating parameter before patient is moved to proceed operation, and do not need to confirm again operating parameter.
Before and after patient is moved; Some take place and move in high intensity focused ultrasound equipment operated position possibly; Move under the acceptable situation of front-back direction difference patient so; Can further calculate the said offset vector that moves between preceding image and the mobile back image; Calculate the side-play amount of the focus of high intensity focused ultrasound equipment then according to this offset vector, and this side-play amount is applied to the operating parameter (especially locus this parameter and with locus relevant parameter) of patient before moving, these operating parameters of high intensity focused ultrasound equipment employing are proceeded subsequent operation.
The above is merely preferred embodiment of the present invention, and is in order to restriction the present invention, not all within spirit of the present invention and principle, any modification of being done, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (8)

1. method that high intensity focused ultrasound operation of equipment parameter can be used once again, this method comprises:
Before patient is moved, use patient with magnetic resonance imaging to scan, image before obtaining moving;
After patient was moved, patient's sick bed was carried in the location, according to the used sweep parameter of image before said the moving, used said patient with magnetic resonance imaging to scan once more, obtained moving the back image;
Move preceding image and move the back image according to said, judge that patient moves front-back direction difference and whether can accept, if then said high intensity focused ultrasound equipment adopts patient to move operating parameter continuation operation before; Otherwise, carry out the step and the subsequent step thereof of locating said sick bed once more;
Wherein, Operating parameter before the employing patient moves continues before the operation; Calculate the said offset vector that moves between preceding image and the mobile back image; Calculate the side-play amount of the focal track of high intensity focused ultrasound equipment according to said offset vector, and be applied to the operating parameter of patient before moving, wherein said operating parameter is a space position parameter.
2. method according to claim 1 is characterized in that, judges patient to move front-back direction difference whether acceptable step comprises:
Cut apart image and the area-of-interest that moves in the image of back before said move, the degree of association of area-of-interest described in the image after calculating image before said the moving and moving, judge the said degree of association whether greater than or more than or equal to a threshold value.
3. method according to claim 2 is characterized in that, this method further comprises: strengthen said preceding image and the edge that moves area-of-interest described in the image of back of moving, so that said cutting apart.
4. method according to claim 3 is characterized in that, uses Canny operator to detect the edge of said area-of-interest.
5. method according to claim 1 and 2 is characterized in that, this method further comprises: the voxel size before making said mobile back image and moving in the image is identical.
6. method according to claim 2 is characterized in that, following formula is adopted in the calculating of the said degree of association:
f ( t ) = Σ p ∈ O [ I f ( p ) - I ‾ f ] [ I t ( p + t ) - I ‾ t ] { Σ p ∈ O [ I f ( p ) - I ‾ f ] 2 Σ p ∈ O [ I t ( p + t ) - I ‾ t ] 2 } 1 / 2
Wherein I ‾ f = 1 n Σ p ∈ O I f ( p ) , I ‾ t = 1 n Σ p ∈ O I t ( p ) ;
Wherein, f (t) is an image and the degree of association that moves area-of-interest in the image of back, I before moving fBe the area-of-interest in the image before moving, I tBe the area-of-interest that moves in the image of back, p is the position of moving area-of-interest in the preceding image, and t is that area-of-interest is with respect to the translation of area-of-interest in the image before moving in the image of mobile back, and n is counting of being considered among the O of overlapping region,
Figure FSB00000826703800021
With
Figure FSB00000826703800022
Be in the O of overlapping region, to calculate to move area-of-interest and the arithmetic average that moves the pixel value of area-of-interest in the image of back in the preceding image.
7. method according to claim 1 and 2 is characterized in that, image before said the moving is carried out down-sampling with mobile back image handle.
8. method according to claim 1 is characterized in that, this method further comprises: move under the acceptable situation of front-back direction difference patient, use said mobile back image to be reference picture.
CN 200810190857 2008-12-31 2008-12-31 Method for reusing operation parameters of high-intensity focused ultrasound equipment Expired - Fee Related CN101766494B (en)

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CN102406517B (en) * 2010-09-21 2013-06-19 上海爱申科技发展股份有限公司 Magnetic resonance guiding and ultrasound focusing tumor ablating machine and locating method thereof
CN103892831A (en) * 2012-12-26 2014-07-02 上海联影医疗科技有限公司 Magnetic resonance imaging method and magnetic resonance system
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US5722411A (en) * 1993-03-12 1998-03-03 Kabushiki Kaisha Toshiba Ultrasound medical treatment apparatus with reduction of noise due to treatment ultrasound irradiation at ultrasound imaging device
CN1584936A (en) * 2004-06-07 2005-02-23 东软飞利浦医疗设备系统有限责任公司 Three-dimensional dividing method for medical images
CN101137003A (en) * 2007-10-15 2008-03-05 北京航空航天大学 Gray associated analysis based sub-pixel fringe extracting method
CN101252886A (en) * 2005-06-29 2008-08-27 艾可瑞公司 Dynamic tracking of soft tissue targets with ultrasound images without using fiducial markers

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5722411A (en) * 1993-03-12 1998-03-03 Kabushiki Kaisha Toshiba Ultrasound medical treatment apparatus with reduction of noise due to treatment ultrasound irradiation at ultrasound imaging device
CN1584936A (en) * 2004-06-07 2005-02-23 东软飞利浦医疗设备系统有限责任公司 Three-dimensional dividing method for medical images
CN101252886A (en) * 2005-06-29 2008-08-27 艾可瑞公司 Dynamic tracking of soft tissue targets with ultrasound images without using fiducial markers
CN101137003A (en) * 2007-10-15 2008-03-05 北京航空航天大学 Gray associated analysis based sub-pixel fringe extracting method

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