CN101759657A - Preparation method of important intermediate of novel febuxostat - Google Patents
Preparation method of important intermediate of novel febuxostat Download PDFInfo
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- CN101759657A CN101759657A CN 200910140337 CN200910140337A CN101759657A CN 101759657 A CN101759657 A CN 101759657A CN 200910140337 CN200910140337 CN 200910140337 CN 200910140337 A CN200910140337 A CN 200910140337A CN 101759657 A CN101759657 A CN 101759657A
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Abstract
The invention relates to a preparation method of important intermediate 2-[3-cyan-(2-isobutoxy) phenyl]-4-methyl-5-thiazolecarboxylate of febuxostat which is a new generation of xanthine oxidase inhibitor. The method takes 2-(4-nitrobenzophenone)-4-methyl-5-thiazolecarboxylate as material to have cyanation reaction and isobutylation reaction under the existence of dimethyl sulfoxide to produce 2-[3-cyan-(2-methylpropoxy) phenyl]-4-methyl-5-thiazolecarboxylate. The material source is wide, the intermediate is easy to prepare, the reaction condition is mild, the operation is easy and the production cost is low, therefore, the preparation method is suitable for industrial production.
Description
Technical field
The present invention relates to a kind of new Febustat important intermediate 2-[3-cyano group-(2-isobutyl-oxygen base) phenyl]-preparation method of 4-methyl-5-thiazole formic acid ethyl ester, belong to the chemical pharmaceutical field.
Background technology
2-[3-cyano group-(2-isobutyl-oxygen base) phenyl]-4-methyl-5-thiazole formic acid ethyl ester is the important intermediate in anti-hyperuricemia medicine Febustat (Febuxostat) building-up process, its structural formula is as shown in the formula shown in (4):
Formula (4)
JP11060552 has reported that formula I compound synthesizes method, with 4-hydroxybenzonitrile and thioacetamide is raw material, in polyphosphoric acid, carry out the Hantzch reaction and obtain 2-(4-hydroxy phenyl)-4-methyl-5-thiazole formic acid ethyl ester with the 2-chloroacetyl acetacetic ester, react in polyphosphoric acid with urotropine then and obtain 2-(3-carboxaldehyde radicals-4-hydroxy phenyl)-4-methyl-5-thiazole formic acid ethyl ester, after last and the isobutane bromide condensation, the aldehyde radical warp obtains I with oxammonium hydrochloride oximate dehydration reaction.Reaction formula is as follows:
Among the preparation method that this synthetic route provided, the yield of 2-(4-hydroxy phenyl)-4-methyl-5-thiazole formic acid ethyl ester is lower, only is 46%, and preparation cost is increased; And in the two-step reaction of preparation 2-(3-carboxaldehyde radicals-4-hydroxy phenyl)-4-methyl-5-thiazole formic acid ethyl ester, all used polyphosphoric acid, in aftertreatment, can produce a large amount of three wastes materials.
Heterocycle, 1998, reported the synthetic method of formula (4) compound at 47 (2): 857, with p-nitrophenyl cyanogen is that raw material and potassium cyanide react generation 1 in DMSO, 3-dicyano phenol, with the isobutane bromide condensation, successively obtain formula (4) more then with thioacetamide, the reaction of 2-chloroacetyl acetacetic ester.Reaction formula is as follows:
Among the preparation method that this synthetic route provided, the yield of 3-cyano-4-isobutoxy benzenesulfonamide is lower, only is 30%, major cause is that two cyano group activity on the prosposition are more or less the same, cause 2,4 all can react, and reaction yield is reduced with thioacetamide.
Summary of the invention
The object of the present invention is to provide a kind of new 2-[3-cyano group-(2-isobutyl-oxygen base) phenyl]-preparation method of 4-methyl-5-thiazole formic acid ethyl ester, it is low to have overcome in the prior art reaction yield, the cost height, the defective that environmental hazard is big, and the raw materials used wide material sources of the present invention are easy to preparation, and reaction conditions gentleness, easy handling, production cost is lower, is suitable for suitability for industrialized production.
Heterocycle, reported the synthetic method of formula (4) compound at 1998,47 (2): 857, first cyano groupization, isobutyl, sulfo-then, last cyclization obtains compound (4).The step of most critical is in the sulfo-process in this technology, the cyano group of contraposition and thioacetamide reaction, but, cause having the ortho position cyano group of part also to participate in reaction, thereby cause generating impurity II because the active cyano group activity with contraposition of adjacent cyano group is more or less the same:
For fear of the generation of impurity II, the present application people considers with the reaction of 2-chloroacetyl acetacetic ester, to react with potassium cyanide more at last then with p-nitrophenyl nitrile elder generation and thioacetamide reaction, generates Compound I, thereby avoids the generation of impurity II.
The invention provides 2-[3-cyano group-(2-isobutyl-oxygen base) phenyl]-preparation method of 4-methyl-5-thiazole formic acid ethyl ester.May further comprise the steps:
With 2-(4-nitrophenyl)-4-methyl-5-thiazole formic acid ethyl ester formula (3) is raw material, and under the condition that dimethyl sulfoxide (DMSO) exists, cyano groupization and isobutyl generate compound (4).
Formula (3) formula (4)
Preparing 2-[3-cyano group-(2-isobutyl-oxygen base) phenyl as mentioned above]-method of 4-methyl-5-thiazole formic acid ethyl ester in, used cyano group reagent is selected from potassium cyanide, sodium cyanide, cuprous cyanide, zinc cyanide, but be preferable over potassium cyanide as cyano group reagent, temperature of reaction 80-120 ℃, the reaction times is 1～5 hour.
In aforesaid method, used isobutyl reagent is selected from isobutane bromide, chloro-iso-butane, and iodo isobutane, but be preferable over isobutane bromide.
Described 2-(4-nitrophenyl)-4-methyl-5-thiazole formic acid ethyl ester, cyano group reagent, isobutyl reagent, the salt of wormwood mol ratio is 1: 1～2: 1～2: 0.5～1; Wherein be preferably 1: 1.5: 2: 0.55.
Prepare 2-[3-cyano group-(2-methyl propoxy-) phenyl as mentioned above]-method of 4-methyl-5-thiazole formic acid ethyl ester in, 2-(4-nitrophenyl)-4-methyl-5-thiazole formic acid ethyl ester, dimethyl sulfoxide (DMSO) W (g): V (ml) is 1: 5～20; Wherein be preferably 1: 15.
In aforesaid method, 2-(4-nitrophenyl)-4-methyl-5-thiazole formic acid ethyl ester formula (3) can be obtained reacting under reflux temperature with 2-chloro-methyl aceto acetate in the presence of the alcoholic acid by p-nitrophenyl sulphamide formula (2).
Formula (2) formula (3)
Recommend being operating as of employing: get the p-nitrophenyl sulphamide and be added in the ethanol, add 2-chloro-methyl aceto acetate then, be warming up to backflow under stirring, reaction finishes, be chilled to room temperature, filter, get white solid 2-(4-nitrophenyl)-4-methyl-5-thiazole formic acid ethyl ester.
In aforesaid method, wherein p-nitrophenyl sulphamide formula (2) can be by p-nitrophenyl nitrile formula (1), and thioacetamide is in the DMF solvent, and temperature is that reaction obtains under 100 ℃:
Formula (2)
That recommend to adopt is operating as: under the room temperature with the p-nitrophenyl nitrile, thioacetamide is put among the DMF (10%HCl), be warming up to 100 ℃ after stirring 5mins, insulation reaction is to TLC tracking no raw material (about 3h), cooling is poured in the frozen water, filters, the filter residue washing, the dry faint yellow solid p-nitrophenyl sulphamide that gets.
Reaction formula of the present invention is as follows:
Embodiment
Further specify technical scheme of the present invention with specific embodiment below, but protection scope of the present invention is not limited thereto:
Embodiment 1
The preparation method of p-nitrophenyl sulphamide:
Under the room temperature with p-nitrophenyl nitrile (10g), thioacetamide (12.7g) is put among the 85mLDMF (10%HCl), be warming up to 100 ℃ after stirring 5mins, insulation reaction is followed the tracks of no raw material (about 3h) to TLC, and cooling is poured in the 30g ice, filter, filter residue washing (20 * 3), dry faint yellow solid 10g, the yield 81% of getting.
Embodiment 2
The preparation method of 2-(4-oil of mirbane)-4-methyl-5-thiazole formic acid ethyl ester:
Get p-nitrophenyl sulphamide (10g) and be added in the 50mL ethanol, 2-chloro-methyl aceto acetate (11.5g) adds, and is warmed up to backflow under stirring, and TLC tracks to no raw material postcooling, filters, and gets white solid 13g, yield 80%.
Embodiment 3
2-[3-cyano group-(2-isobutyl-oxygen base) phenyl]-preparation method of 4-methyl-5-thiazole formic acid ethyl ester:
Get 2-(4-oil of mirbane)-4-methyl-5-thiazole formic acid ethyl ester (14.8g), potassium cyanide (4.9g) is added under room temperature among the 150mL DMSO, stirs, and is heated to 102 ℃, insulation reaction to TLC follow the tracks of no raw material (about 2～3h), cooling, adding K
2CO
3(3.8g), isobutane bromide (16g) is warmed up to 80 ℃ under stirring, and insulation reaction is followed the tracks of to TLC and reacted completely (about 7
H), cooling is poured in the ice, ethyl acetate extraction, organic layer washing, drying, be spin-dried for yellow solid, re-crystallizing in ethyl acetate gets 15g off-white color solid, yield 85%.
Embodiment 4
2-[3-cyano group-(2-isobutyl-oxygen base) phenyl]-preparation method of 4-methyl-5-thiazole formic acid ethyl ester:
Get 2-(4-oil of mirbane)-4-methyl-5-thiazole formic acid ethyl ester (14.8g), sodium cyanide (3.7g) is added under room temperature among the 100mL DMSO, stirs, and is heated to 102 ℃, insulation reaction to TLC follow the tracks of no raw material (about 2～3h), cooling, adding K
2CO
3(3.8g), isobutane bromide (16g) is warmed up to 80 ℃ under stirring, and insulation reaction is followed the tracks of react completely (about 7h) to TLC, cooling is poured in the ice, ethyl acetate extraction, organic layer washing, drying, be spin-dried for yellow solid, re-crystallizing in ethyl acetate gets 12g off-white color solid, yield 68%.
Embodiment 5
2-[3-cyano group-(2-isobutyl-oxygen base) phenyl]-preparation method of 4-methyl-5-thiazole formic acid ethyl ester:
Get 2-(4-oil of mirbane)-4-methyl-5-thiazole formic acid ethyl ester (14.8g), potassium cyanide (4.9g) is added under room temperature among the 100mL DMSO, stirs, and is heated to 102 ℃, insulation reaction to TLC follow the tracks of no raw material (about 2～3h), cooling, adding K
2CO
3(3.8g), chloro-iso-butane (10.8g) is warmed up to 80 ℃ under stirring, and insulation reaction is followed the tracks of react completely (about 7h) to TLC, cooling is poured in the ice, ethyl acetate extraction, organic layer washing, drying, be spin-dried for yellow solid, re-crystallizing in ethyl acetate gets 15g off-white color solid, yield 80%.
Embodiment 6
2-[3-cyano group-(2-isobutyl-oxygen base) phenyl]-preparation method of 4-methyl-5-thiazole formic acid ethyl ester:
Get 2-(4-oil of mirbane)-4-methyl-5-thiazole formic acid ethyl ester (14.8g), sodium cyanide (3.7g) is added under room temperature among the 150mL DMSO, stirs, and is heated to 102 ℃, insulation reaction to TLC follow the tracks of no raw material (about 2～3h), cooling, adding K
2CO
3(3.8g), chloro-iso-butane (16g) is warmed up to 80 ℃ under stirring, and insulation reaction is followed the tracks of react completely (about 7h) to TLC, cooling is poured in the ice, ethyl acetate extraction, organic layer washing, drying, be spin-dried for yellow solid, re-crystallizing in ethyl acetate gets 10g off-white color solid, yield 62%.
Claims (10)
1. 2-[3-cyano group-(2-isobutyl-oxygen base) phenyl]-synthetic method of 4-methyl-5-thiazole formic acid ethyl ester formula (4), it is characterized in that with 2-(4-nitrophenyl)-4-methyl-5-thiazole formic acid ethyl ester formula (3) be raw material, under the condition that dimethyl sulfoxide (DMSO) exists, cyano groupization and isobutyl generate 2-[3-cyano group-(2-isobutyl-oxygen base) phenyl]-4-methyl-5-thiazole formic acid ethyl ester formula (4).
Formula (3) formula (4)
2. preparation method according to claim 1 is characterized in that described cyano group reagent is potassium cyanide, sodium cyanide, cuprous cyanide, zinc cyanide.
3. preparation method according to claim 2 is characterized in that described cyano group reagent is preferably potassium cyanide.
4. preparation method according to claim 1 is characterized in that described isobutyl reagent is isobutane bromide, chloro-iso-butane, iodo isobutane.
5. according to the described preparation method of claim 4, it is characterized in that described isobutyl reagent is preferably isobutane bromide.
6. preparation method according to claim 1 is characterized in that, the temperature of described 2-(4-nitrophenyl)-4-methyl-5-thiazole formic acid ethyl ester and potassium cyanide reaction is 80-120 ℃, and the reaction times is 1～5 hour.
7. preparation method according to claim 1 is characterized in that described 2-(4-nitrophenyl)-4-methyl-5-thiazole formic acid ethyl ester, cyano group reagent, and isobutyl reagent, the salt of wormwood mol ratio is 1: 1～2: 1～2: 0.5～1; Wherein be preferably 1: 1.5: 2: 0.55.
8. preparation method according to claim 1 is characterized in that described 2-(4-nitrophenyl)-4-methyl-5-thiazole formic acid ethyl ester, and dimethyl sulfoxide (DMSO) W (g): V (ml) is 1: 5～20; Wherein be preferably 1: 15.
9. preparation method according to claim 1,2-(4-nitrophenyl)-4-methyl-5-thiazole formic acid ethyl ester formula (3) can be obtained reacting under reflux temperature with 2-chloro-methyl aceto acetate in the presence of the alcoholic acid by p-nitrophenyl sulphamide formula (2).
Formula (2) formula (3)
10. method according to claim 9, wherein p-nitrophenyl sulphamide formula (2) can be by p-nitrophenyl nitrile formula (1), and thioacetamide is in the DMF solvent, and temperature is that reaction obtains under 100 ℃:
Formula (2)
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| CN 200910140337 CN101759657A (en) | 2009-07-11 | 2009-07-11 | Preparation method of important intermediate of novel febuxostat |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102424675A (en) * | 2011-11-07 | 2012-04-25 | 镇江市高等专科学校 | Method for preparing 2-amino-3-cyan benzopyran derivative |
| CN115572272A (en) * | 2022-11-15 | 2023-01-06 | 湖北华世通生物医药科技有限公司 | Preparation method of febuxostat and aldehyde ester intermediate thereof |
-
2009
- 2009-07-11 CN CN 200910140337 patent/CN101759657A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102424675A (en) * | 2011-11-07 | 2012-04-25 | 镇江市高等专科学校 | Method for preparing 2-amino-3-cyan benzopyran derivative |
| CN115572272A (en) * | 2022-11-15 | 2023-01-06 | 湖北华世通生物医药科技有限公司 | Preparation method of febuxostat and aldehyde ester intermediate thereof |
| CN115572272B (en) * | 2022-11-15 | 2024-05-07 | 湖北华世通生物医药科技有限公司 | Preparation method of febuxostat and aldehyde ester intermediate thereof |
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Application publication date: 20100630 |