CN101743955B - 20% ivermectin.Dursban EW (Emulsion in Water) - Google Patents

Abstract

The invention discloses a 20% ivermectin.Dursban EW which is an insecticide and acaricide. The EW is compounded from ivermectin and Dursban, maintains the advantages of the ivermectin and increase the bioactivity of the ivermectin. Compared with emulsifiable concentrate, the EW contains no or little poisonous and flammable benzene solvents or other organic solvents, has no risk of fire, no toxic gas and small eye irritation, reduces the pollution to the environment, significantly improves the safety of people involved in production, transport and using, greatly reduces the toxicity to warm-blooded animals, is safer to plant than emulsifiable concentrate, and has low cost, stable prevention effect and better effect than single chemical agent; in addition, the preparation of the EW does not need special equipment, is simple and convenient to operate and is easy to promote.

Description

20% ivermectin chlorpyrifos aqueous emulsion

Technical field

The present invention relates to technical field of pesticide, particularly relate to a kind of Insecticidal and acaricidal agent 20% ivermectin chlorpyrifos aqueous emulsion.

Background technology

Current with efficient, safety, economy, conveniently be that the pesticides new formulation of target is developed, caused widely and paid close attention to.The novel form of wanting to pursue is: Water-borne modification, spheroidizing, slowly-releasingization, lowly poison, multifunction and laborsavingization.The liquid formulation Water-borne modification is meant with water to be the formulations of pesticide of matrix preparation, like suspension emulsion, aqueous emulsion and microemulsion etc.The solid formulation graininessization is meant with water dispersible granules, effervescent tablet etc. and replaces pulvis and wetting powder.

Traditional liquor agricultural chemicals is main with missible oil; Must add a large amount of organic solvents when producing missible oil; These organic solvents are main with triphen inflammable and explosive, harmful to people and animals, contaminated environment again; In production, storage and use, be absolutely unsafe, developed country has forbidden or part forbids on fruit tree, vegetables, using.The valuable industrial chemicals that will not have drug effect in addition in a large number is sprayed onto Tanaka, also is a kind of wasting of resources.Account for the missible oil of China pesticide producing amount 50%-60%, will expend 250,000 tons of organic solvents that are worth 1,000,000,000 yuan more than every year, and these 250,000 tons of organic solvents have caused negative influence to environment.Therefore, novel form aqueous emulsion and microemulsion with water replacement or minimizing organic solvent will progressively replace conventional dosage forms--missible oil.

Since the eighties in 20th century, because the promotion of Environmental security, food security, the research and development development of water baseization pesticides new formulation rapidly; Since 2002; In short supply along with the petrochemical industry resource, the development of water baseization novel form is obviously quickened, and wherein aqueous emulsion and microemulsion more receive much attention.And in the two kinds of water baseization formulations (aqueous emulsion and microemulsion) that substitute missible oil, aqueous emulsion shines than the better vitality of microemulsion.

Microemulsion (ME) is the former medicine of liquid pesticidal or is dispersed in formed transparent or semitransparent microemulsion system behind the aqueous solution that contains the exhibiting high surface activating agent with pesticide original medicine solution that solvent is mixed with.The amount of surfactant that microemulsion adds is 2-3 a times of aqueous emulsion; And generally need add the solubilizer (being mainly hydrophilic straight or branched alcohol, ketone etc.) about 10%; These material acute toxicities are suitable with xylol, and are hydrophilic polar solvent, more are prone to dissolve in farmland and water source; Remove and separates more difficultly than non-polar solvens such as benzene classes, chronic toxicity is very important.Therefore microemulsion has added new threat to environment and food security, and the exploitation of this formulation is restricted, and also wants the careful microemulsion of using for vegetables field, paddy field, the indoor health medication of weak point in vegetative period.The microemulsion production cost is higher than aqueous emulsion in addition.

Pesticide emulsion in water (EW) is the water-fast solution that former medicine of water-fast liquid state or solid-state former medicine are dissolved in the organic solvent gained; Be dispersed into emulsification particulate about 1 micron in water; A kind of environmentally friendly type pesticidal preparations that forms, outward appearance is an opaque and white milk shape emulsion.Water emulsion formula is formed simple, and liquid former medicine preparation aqueous emulsion is used solvent hardly, and water has replaced a large amount of triphen class organic solvents, is internationally recognized environmentally safe pesticides new formulation, and production cost reduces greatly.Aqueous emulsion is a kind of ideal pesticide novel form that replaces missible oil.Because aqueous emulsion is in the thermodynamic instability state, must do in order to forming uniform emulsion by specific external force, and keep 2 years stable, so control relative complex of formula development and production process.

To the pesticide emulsion in water product 118 (wherein overseas enterprise 12) of the end of the year 2004 in China's registration, 183 of microemulsion products (wherein overseas enterprise is 0).Registering 171 of aqueous emulsion products (wherein overseas enterprise is 12) end of the year 2005 increases with 44.9% speed.Registration 263 of products of microemulsion (wherein overseas enterprise is 0), the speed with 43.7% increases.Here there are 2 kinds of situation can not be ignored, the one, present China has become the maximum country of microemulsion production, and the formulation of main research and extension is an aqueous emulsion abroad, just is based on the consideration of environmental protection.The 2nd, the aqueous emulsion product of China registration is merely about 1% of all registration Pesticidal products respectively with the microemulsion product, the ratio that in whole Pesticidal products, accounts for well below developed country's aqua type agricultural chemicals.

Aqueous emulsion replaces whole or most of organic solvents with water, and the active component drop disperses back particle diameter＜2 microns, the outward appearance milk shape that is white in color, during dilute with water with missible oil pour in the water outward appearance do not have different, easily by peasant's recognition and acceptance.Comparing with missible oil has more advantage on manufacturing, safety in utilization, cost, transportation, packing.Since do not contain or only contain a small amount of poisonous inflammable organic solvent, unassured fiery fried dangerous, reduced pollution to environment, improved safety greatly to production, storing and user.Water with cheapness is matrix, and cost also has the reduction of different amplitudes.Requirement to packing container also can not show a candle to the missible oil harshness, can reduce packing cost.Warm blooded animal toxicity is reduced greatly,, good to plant with other agricultural chemicals and fertilizer miscibilty than missible oil safety.The mist droplet particle size that atomizes during sprinkling is bigger than missible oil, can reduce the drift of active ingredient and to the pollution of environment, and vestiges and missible oil after not having wetting powder to spray after using make phenomenons such as the fruit powder comes off.Aqueous emulsion and aqueous suspension agent are mixed and can prepare suspended emulsion, and aqueous emulsion also can be mixed with aqua, the preparation aqueous emulsion.

Because aqueous emulsion has the unrivaled advantage of above-mentioned other formulations of pesticide, the expert thinks that aqueous emulsion is more suitable for China's national situation, will be promoted rapidly and develop, and replace missible oil to a certain extent, progressively develops into the large-tonnage product.

In sum; Aqueous emulsion is internationally recognized environmentally safe pesticides new formulation; More paying attention to environmental protection, global petrochemical industry resource scarcity; Price raises up under the new situation, invents the aqueous emulsion of various pesticide active ingredients and applies, for building a conservation-minded society and realizing that the pesticide industry sustainable development is significant.

Ivermectin (ivermectin) is novel wide spectrum, efficient, low toxicity antibiotics desinsection, kills mite and nematicide medicament, and particularly nematode and arthropods all have the good effect of killing to endoparasite and ectoparasite.Its mechanism of action is to increase the release of the inhibitory transmitter GABA of polypide, and the cl that opens glutamic acid control ^-Passage, increase neu to cl ^-Permeability, thereby the transmission of block nerves signal, final neural paralysis makes muscle cell lose contractility, and causes polypide dead.With at present on agricultural the homologue AVM of extensive use compare, the toxicity of ivermectin is lower, stability is better, can prevent and treat the insect to AVM generation resistance, harmful mite.Ivermectin uses mainly as veterinary drug and on agricultural, uses less at present.If can ivermectin and suitable pesticide compositional be increased virulence, reduce cost, then will open up the new prospect that ivermectin is used at agriculture field.

At present as the main formulation of the ivermectin of agriculture chemical registration and report missible oil and microemulsion are arranged, preparation all is single agent.

Chlopyrifos (chlorpyridos) is an organic phosphor low toxicity insecticidal/acaricidal agent.Its insecticidal spectrum is wide, have tag, stomach toxicity and fumigation action.Become the ideal substitute kinds of 5 kinds of forbidding high-toxic pesticides gradually with characteristics such as its insecticidal spectrum are wide, safe, efficient.Chlopyrifos obtains registration in the control of insect of a lot of crops, like cotton aphid, and apple peach fruit borer, woolly aphid.Paddy rice two, paddy stem borer, rice leaf roller, plant hopper, leaf vegetables aphid, cabbage caterpillar, citrus red mite etc.

The formulation of single agent of chlopyrifos or composite dose of registration is main with missible oil also.

Therefore make composite dose to ivermectin and chlopyrifos, the effect that not only has synergy, delaying drug resistance, but also can remedy the deficiency of two single agent, become the outstanding Insecticidal and acaricidal agent that an existing quick-acting has lasting effect again.

Existing at present research report about " ivermectin and chlorpyrifos mixture agricultural chemicals ", but mainly be the compound proportion that stresses ivermectin and chlopyrifos, do not see the research report of relevant 20% ivermectin chlorpyrifos aqueous emulsion both at home and abroad as yet.

Summary of the invention

The objective of the invention is to overcome the deficiency of existing product, a kind of environment amenable novel form ivermectin and chlorpyrifos mixture preparation---20% ivermectin chlorpyrifos aqueous emulsion is provided.

The component of 20% ivermectin chlorpyrifos aqueous emulsion and quality percentage composition thereof are following:

Chlopyrifos 19.75%

Ivermectin 0.25%

Organic solvent 15%

Surfactant polyethers L-64 8%

Urea 5%

Deionized water complements to 100%

Organic solvent is toluene and N, and the mixture of dinethylformamide, its mass ratio are toluene: N, dinethylformamide=3: 1.

The production technology of the present invention's 20% ivermectin chlorpyrifos aqueous emulsion is following:

According to above-mentioned each component and content, use earlier N, dinethylformamide dissolving ivermectin; Add the former medicine of chlopyrifos then, after the dissolving of interpolation toluene, add surfactant in solution for continuous; Stir then, obtain transparent mother liquor, under the effect of magnetic stirring apparatus; Splash into the gauge water solution that adds antifreeze urea in this mother liquor, obtain even milky white solution, evenly get final product with efficient emulsification pretreatment machine shearing then.

This technology does not need special installation, and is easy and simple to handle, is easy to promote.

Description of drawings

Fig. 1 is the technological process of production sketch map of 20% ivermectin chlorpyrifos aqueous emulsion

Advantage of the present invention is:

(1) with ivermectin as pesticide developing, the advantage of ivermectin is: 1. toxicity is lower than AVM; 2. stability is better than AVM; 3. can prevent and treat the insect that AVM is produced resistance.The present invention when keeping the ivermectin advantage, has increased its biologically active with ivermectin and chlorpyrifos mixture, reduces cost through reducing consumption, and making ivermectin use as agricultural chemicals becomes possibility fully.

(2) formulation is advanced, is environmentally friendly green formulation.

Aqueous emulsion is compared with missible oil, does not contain or contain a small amount of poisonous inflammable organic solvents such as benzene class, does not have the danger of catching fire; No unpleasant toxic gas; Little to eye irritation, reduced pollution to environment, improved safety greatly to production, storing and user; Toxicity to warm blooded animal reduces greatly, to plant than missible oil safety.Good with the miscibilty of other agricultural chemicals or fertilizer.

(3) practice thrift cost.

Aqueous emulsion is matrix with water, and the emulsifier consumption is 2-10%, and is close with missible oil; In addition, through with ivermectin and chlorpyrifos mixture, composite effect shows as synergy; Reduce the unit administration amount of ivermectin simultaneously, thereby can overcome the higher shortcoming of ivermectin price.

(4) preventive effect is stable, and effect is superior to single agent.

Experiment showed, that the aqueous emulsion drug effect is with suitable with the corresponding missible oil of dosage.Chlopyrifos and ivermectin are composite, and not only preventive effect is stablized (ivermectin character is more stable than AVM), and the insect of AVM generation resistance is also had good preventive effect.Because composite dose has synergy, therefore than the agent of ivermectin list effective (concrete experimental data is seen embodiment).

Comprehensive foregoing invention advantage, this invention product cost is lower, and the formulations of pesticide are aqueous emulsion, are main solvent with water, have not only saved a large amount of organic solvents, and have alleviated the pressure to environment greatly.

Embodiment

Preparing 20% ivermectin chlorpyrifos aqueous emulsion by said components, content and preparation technology tests as follows

The effect experiment of Tetranychus cinnabarinus on (1) the 20% ivermectin chlorpyrifos aqueous emulsion control cowpea; The result shows: 2000 times of liquid of 20% ivermectin chlorpyrifos aqueous emulsion are handled has the better prevention effect to Tetranychus cinnabarinus; The preventive effect of 1-7d maintains between the 87.22%-99.37% behind the medicine; Particularly behind medicine, reached 93.10% on the 3rd day, 7 days is 99.37% behind medicine, and preventive effect is remarkable.Medicament is in application, and smell significantly less than contrast missible oil, has reduced the pollution to environment.

The effect experiment of diamond-back moth on (2) the 20% ivermectin chlorpyrifos aqueous emulsions control wild cabbage; The result shows: 1000 times of liquid of 20% ivermectin chlorpyrifos aqueous emulsion are handled has the better prevention effect to diamond-back moth; The preventive effect of 7-21d maintains between the 90.32%-94.57% behind the medicine, particularly behind medicine, reaches 92.99% on the 14th day, and 21 days is 94.57% behind medicine; Preventive effect is remarkable, and the lasting period is long.Medicament is in application, and smell significantly less than contrast missible oil, has reduced the pollution to environment.

Claims (1)

1. an ivermectin chlorpyrifos aqueous emulsion is characterized in that, the component of this aqueous emulsion and quality percentage composition thereof are following:

Chlopyrifos 19.75%

Ivermectin 0.25%

Organic solvent 15%

Surfactant polyethers L-64 8%

Urea 5%

Deionized water complements to 100%

Organic solvent is toluene and N, and the mixture of dinethylformamide, its mass ratio are toluene: N, dinethylformamide=3: 1.

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