CN101732283B - Method for preparing colloidal pectin bismuth microcapsules - Google Patents
Method for preparing colloidal pectin bismuth microcapsules Download PDFInfo
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- CN101732283B CN101732283B CN2009101570213A CN200910157021A CN101732283B CN 101732283 B CN101732283 B CN 101732283B CN 2009101570213 A CN2009101570213 A CN 2009101570213A CN 200910157021 A CN200910157021 A CN 200910157021A CN 101732283 B CN101732283 B CN 101732283B
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- pectin
- bismuth
- pectin bismuth
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Abstract
The invention belongs to the medicaments and in particular relates to a method for preparing colloidal pectin bismuth microcapsules. The method is characterized by comprising the following steps: adding a pure colloidal pectin bismuth wet or dry product into water with the temperature of between 50 and 100 DEG C to form mucilage, and adding a disintegrating agent into the mucilage, wherein the weight ratio of the disintegrating agent to the colloidal pectin bismuth is 1-10 : 5-100; and adding aqueous solution of a bonding agent into the mixture, wherein the weight ratio of the bonding agent to the colloidal pectin bismuth is 0-10:10-200, uniformly mixing, homogenizing, and performing direct spray drying on the mixture to prepare the microcapsules, or after drying, pulverizing the microcapsules into micron microcapsule powder by vibration mill (or jet mill). The prepared colloidal pectin bismuth microcapsules can well expand and disperse in stomach, form enough gel volume, and can cover all ulcer parts. Meanwhile, the method can prepare corresponding colloidal pectin bismuth microcapsules according to different types of patients, so that the medicament has corresponding mucosa strength and antibacterial strength in the stomach of the patient and has better treatment effect.
Description
Technical field
The invention belongs to pharmaceutical, specifically is a kind of preparation method of colloidal pectin bismuth microcapsules.
Background technology
Colloidal bismmth pectin be China initiative a kind of colloidal state bismuth for the treatment of peptic ulcer and chronic gastritis, in gastric acid environment, form gelinite, cover gastric mucosa surface, rotten to the corn face and ulcer and gastric acid and pepsin are isolated, impaired mucosa is played a protective role; But the healing of ulcer surface and the disappearance of inflammation are quickened in the generation of stimulation of endogenous prostaglandin and epidermal growth factor, have certain anastalsis simultaneously; In medication combined treatment, the bismuth pectin gel can prolong the time of staying of antibiotic at gastric, improve the concentration of antibiotic in ulcer and inflammation tissue, help killing and eradicating of gastric helicobacter pylori, bismuth pectin self has certain antibacterial activity simultaneously; Bismuth pectin is a kind of novel macromolecule bismuth, and molecular weight is big, and is colloid-stabilised, is difficult to be absorbed by the body, and does not have untoward reaction and side effect that similar medicine causes easily.Be mainly used in the treatment chronic gastritis, this external enwergy is killed helicobacter pylori, promotes the gastritis healing.Existing colloidal bismmth pectin is mainly made capsule form, and the colloidal bismmth pectin capsule is mainly used in gastric and duodenal ulcers, also can be used for the treatment of chronic superficial gastritis, chronic atrophic gastritis and digestive tract hemorrhage.With the antibiotic associating, be used for the eradication therapy of stomach Helicobacter pylori.
But because the pectin viscosity of colloidal bismmth pectin and bigger particle diameter, we find, colloidal bismmth pectin dispersions of can not expanding preferably under one's belt, and just the gel volume that forms under the usual amounts is big inadequately, less or ulcer place, the ulcer place that can be covered to is difficult for covering, and has reduced the curative effect of these product.In addition, the mucosa insufficient strength that colloidal bismmth pectin forms in some patients' stomach, destroyed easily, also be one of not enough reason of this product curative effect.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art, a kind of preparation method of colloidal pectin bismuth microcapsules is provided, and big with expand under one's belt good dispersion, gel volume of the colloidal pectin bismuth microcapsules of this method preparation, the mucosa intensity that forms in patient's stomach is big, be difficult for destroyedly, therapeutic effect is better.
Technical scheme of the present invention is as follows:
A kind of preparation method of colloidal pectin bismuth microcapsules, it is characterized in that: with wet product of purified colloidal bismmth pectin or dry product, join in 50 to 100 ℃ of water and form rubber cement, add disintegrating agent, disintegrating agent is 1～10: 5～100 with the ratio of colloidal bismmth pectin weight, adds the aqueous solution of binding agent again, binding agent is 0～10: 10～200 with the ratio of colloidal bismmth pectin weight, mixing, homogenizing, directly spray drying forms microcapsule; Or after the drying, be ground into micron-sized microcapsule powder with vibromill (or airflow milling).
Disintegrating agent of the present invention is any one or any two kinds of couplings such as crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, starch.
Binding agent of the present invention is any one or any two kinds of couplings such as hypromellose, sodium carboxymethyl cellulose, carbomer, Polyethylene Glycol, sucrose, polyvinylpyrrolidone, methylcellulose, hydroxyethyl-cellulose, arabic gum, gelatin, guar gum, chitosan, tragakanta, HUANGJIAO, polyvinyl alcohol, sodium alginate.
Homogenizing of the present invention adopted colloid mill or high pressure homogenizer, and the homogenization pressure of high pressure homogenizer is 10MPa～80MPa.
The colloidal pectin bismuth microcapsules that the present invention the makes dispersion of well expanding under one's belt forms enough big gel volume, can cover all ulcer places.Simultaneously, can prepare corresponding colloidal pectin bismuth microcapsules according to dissimilar patients, make medicine form corresponding mucosa intensity and antibacterial strength in patient's stomach, therapeutic effect is better.
The specific embodiment
Embodiment one
With the wet product of 130 gram colloidal bismmth pectin, join in 50 to 100 ℃ of water and form rubber cement, add 3 gram carboxymethyl starch sodium, add the aqueous solution that contains 2 gram sodium carboxymethyl cellulose, 1 gram carbomer again, mixing is crossed colloid mill, the medicine liquid spray drying is formed microcapsule, get 83 gram powder.Laser particle diameter instrument is measured, and powder diameter becomes normal distribution, and mean diameter is 27 microns.Experiment in vitro confirms that expansion effect and film property all are better than common colloidal bismmth pectin.
Embodiment two
With 103 gram colloidal bismmth pectin dry products, join in 70 ℃ of water and form rubber cement, add crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, the aqueous solution that adds Polyethylene Glycol 8000 again, mixing is crossed high pressure homogenizer, and homogenization pressure is 30MPa, the medicine liquid spray drying is formed microcapsule, get 81 gram powder.Laser particle diameter instrument is measured, and powder diameter becomes normal distribution, and mean diameter is 6.2 microns.Experiment in vitro confirms that expansion effect and film property all are better than common colloidal bismmth pectin.
Embodiment three
With 97 gram colloidal bismmth pectin dry products, join in 85 ℃ of water and form rubber cement, add cross-linking sodium carboxymethyl cellulose, low-substituted hydroxypropyl cellulose, the aqueous solution that adds hydroxyethyl-cellulose, arabic gum again, mixing is crossed high pressure homogenizer, and homogenization pressure is 60MPa, the medicine liquid spray drying is formed microcapsule, get 79 gram powder.Laser particle diameter instrument is measured, and powder diameter becomes normal distribution, and mean diameter is 3.1 microns.Experiment in vitro confirms that expansion effect and film property all are better than common colloidal bismmth pectin.
Embodiment four
With the wet product of 135 gram colloidal bismmth pectin, adds in 75 ℃ of water and form rubber cement, add 3 gram carboxymethyl starch sodium, 10 gram starch, add the aqueous solution of methylcellulose again, mixing is crossed colloid mill, and drying is pulverized with vibromill, gets 92 and restrains the microcapsule powder.Laser particle diameter instrument is measured, and powder diameter becomes normal distribution, and mean diameter is 16 microns.Experiment in vitro confirms that expansion effect and film property all are better than common colloidal bismmth pectin.Experiment in vitro confirms that expansion effect and film property all are better than common colloidal bismmth pectin.
Embodiment five
With the wet product of 1300 gram colloidal bismmth pectin, join in about 65 ℃ of water and form rubber cement, add 100 gram starch, add the aqueous solution that contains 120 gram sucrose, 60 gram polyvinylpyrrolidones again, mixing is crossed high pressure homogenizer 70MPa, drying is pulverized with airflow milling, gets 897 gram microcapsule powder.Laser particle diameter instrument is measured, and powder diameter becomes normal distribution, and mean diameter is 1.3 microns.Experiment in vitro confirms that expansion effect and film property all are better than common colloidal bismmth pectin.
Embodiment six
With 560 gram colloidal bismmth pectin dry products, join in about 95 ℃ of water and form rubber cement, add 6 gram crospolyvinylpyrrolidone, 12 gram low-substituted hydroxypropyl celluloses, add the aqueous solution that contains tragakanta 15 grams again, mixing is crossed colloid mill, drying is pulverized with vibromill, gets 520 gram microcapsule powder.Laser particle diameter instrument is measured, and powder diameter becomes normal distribution, and mean diameter is 17 microns.Experiment in vitro confirms that expansion effect and film property all are better than common colloidal bismmth pectin.
Claims (5)
1. the manufacture method of a colloidal pectin bismuth microcapsules, it is characterized in that: with wet product of colloidal bismmth pectin or dry product, join in 50 to 100 ℃ of water and form rubber cement, add disintegrating agent, disintegrating agent is 1～10: 5～100 with the ratio of colloidal bismmth pectin weight, adds the aqueous solution of binding agent again, binding agent is 0～10: 10～200 with the ratio of colloidal bismmth pectin weight, mixing, homogenizing, directly spray drying forms microcapsule.
2. the manufacture method of a colloidal pectin bismuth microcapsules, it is characterized in that: with wet product of colloidal bismmth pectin or dry product, join in 50 to 100 ℃ of water and form rubber cement, add disintegrating agent, disintegrating agent is 1～10: 5～100 with the ratio of colloidal bismmth pectin weight, adds the aqueous solution of binding agent again, binding agent is 0～10: 10～200 with the ratio of colloidal bismmth pectin weight, mixing, homogenizing, crushed after being dried becomes micron-sized microcapsule powder.
3. the manufacture method of colloidal pectin bismuth microcapsules according to claim 1 and 2 is characterized in that: described disintegrating agent is any one or any two kinds of couplings of crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, starch.
4. the manufacture method of colloidal pectin bismuth microcapsules according to claim 1 and 2 is characterized in that: described binding agent is any one or any two kinds of couplings of hypromellose, sodium carboxymethyl cellulose, carbomer, Polyethylene Glycol, sucrose, polyvinylpyrrolidone, methylcellulose, hydroxyethyl-cellulose, arabic gum, gelatin, guar gum, chitosan, tragakanta, HUANGJIAO, polyvinyl alcohol, sodium alginate.
5. the manufacture method of colloidal pectin bismuth microcapsules according to claim 1 and 2, it is characterized in that: homogenizing adopted colloid mill or high pressure homogenizer, and the homogenization pressure of high pressure homogenizer is 10MPa～80 MPa.
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| CN2009101570213A CN101732283B (en) | 2009-12-29 | 2009-12-29 | Method for preparing colloidal pectin bismuth microcapsules |
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| CN2009101570213A CN101732283B (en) | 2009-12-29 | 2009-12-29 | Method for preparing colloidal pectin bismuth microcapsules |
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| CN101732283A CN101732283A (en) | 2010-06-16 |
| CN101732283B true CN101732283B (en) | 2011-09-21 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105467071B (en) * | 2015-04-07 | 2018-07-17 | 湖南华纳大药厂股份有限公司 | A kind of quality control of colloidal bismmth pectin pharmaceutical composition and its assay method of galacturonic acid content |
| CN105213440A (en) * | 2015-09-21 | 2016-01-06 | 金华市荆龙生物科技有限公司 | A kind of Herba Anoectochili roxburghii microcapsule and preparation method thereof |
| CN106699925B (en) * | 2016-12-29 | 2019-05-28 | 山西振东安特生物制药有限公司 | A kind of molten type chitosan-bismuth of acid and its preparation method and application |
| CN110200935B (en) * | 2019-06-03 | 2021-03-02 | 浙江得恩德制药股份有限公司 | Colloidal bismuth pectin capsule and preparation process thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088437A (en) * | 1992-12-23 | 1994-06-29 | 大同市药物研究所 | Jellied pectin bismuth medicine |
| CN1634132A (en) * | 2003-12-29 | 2005-07-06 | 湖南华纳大药厂有限公司 | Dispersible tablet of colloid petcin |
| CN101028281A (en) * | 2007-04-29 | 2007-09-05 | 于学敏 | Nano-gel pectin bismuth and its granules medicine |
| CN101491512A (en) * | 2008-01-22 | 2009-07-29 | 北京申科联华科技有限公司 | Bismuth salt composite for treating stomach intestine disease and preparation method thereof |
-
2009
- 2009-12-29 CN CN2009101570213A patent/CN101732283B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088437A (en) * | 1992-12-23 | 1994-06-29 | 大同市药物研究所 | Jellied pectin bismuth medicine |
| CN1634132A (en) * | 2003-12-29 | 2005-07-06 | 湖南华纳大药厂有限公司 | Dispersible tablet of colloid petcin |
| CN101028281A (en) * | 2007-04-29 | 2007-09-05 | 于学敏 | Nano-gel pectin bismuth and its granules medicine |
| CN101491512A (en) * | 2008-01-22 | 2009-07-29 | 北京申科联华科技有限公司 | Bismuth salt composite for treating stomach intestine disease and preparation method thereof |
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| CN101732283A (en) | 2010-06-16 |
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