CN101731221B - Sterilizing composition - Google Patents
Sterilizing composition Download PDFInfo
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- CN101731221B CN101731221B CN200910261170A CN200910261170A CN101731221B CN 101731221 B CN101731221 B CN 101731221B CN 200910261170 A CN200910261170 A CN 200910261170A CN 200910261170 A CN200910261170 A CN 200910261170A CN 101731221 B CN101731221 B CN 101731221B
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- Prior art keywords
- dithianon
- bromothalonil
- composition
- water
- bactericidal composition
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- 230000001954 sterilising effect Effects 0.000 title abstract description 4
- 239000005764 Dithianon Substances 0.000 claims abstract description 58
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- DHVLDKHFGIVEIP-UHFFFAOYSA-N 2-bromo-2-(bromomethyl)pentanedinitrile Chemical compound BrCC(Br)(C#N)CCC#N DHVLDKHFGIVEIP-UHFFFAOYSA-N 0.000 claims abstract description 51
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a sterilizing composition comprising active components, i.e. dithianon and bromothalonil in a weight part ratio of 1:80-80:1. The composition can be used for preventing and curing cereal, fruit tree and vegetable crop diseases and has the outstanding advantages of synergism, expanding prevention and cure spectrum, lowering cost, delaying resistance to drugs and the like.
Description
Technical field
The present invention relates to a kind of bactericidal composition and uses thereof, especially a kind ofly contain the combination sterilization composition of dithianon and the application on control of crop disease thereof.
Background technology
Dithianon (dithianon) is the bactericide of BASF European Co.,Ltd's exploitation, and pure article are dark-brown crystalloid solid.Molecular formula is C
14H
4N
2O
2S
2, chemical name is: 2, and 3-dinitrile-1,4-anthraquinone dithio.Dithianon has the multiple mechanism of action; Suppress a series of fungal enzyme through sulfur-containing group reaction and interference cell breathing; Cause germ dead at last, when having good protection activity, certain therapeutic activity is arranged also; Its controlling object comprises that almost all fruit diseases are like scab, mildew disease, leaf spot, anthracnose, rust, shot hole, downy mildew, brown rot etc. except powdery mildew.
At present, the dithianon formulation products has 66% dithianon water-dispersion granule, 22.7% dithianon suspending agent, is mainly used in control vegetables anthracnose.But long-term single application dithianon has very high resistance risk.。Composite through itself and different cultivars composition are carried out, be to avoid one of effective way that the resistance germ produces.Different cultivars is carried out composite, and according to the effect of practical application, judging composite is synergy or antagonism, and the prescription that compound synergic is good can obviously improve actual control efficiency, reduces the usage amount of agricultural chemicals, thereby delays the generation of germ resistance.
At present dithianon and bromothalonil composite still nobody reported.
Summary of the invention
The purpose of this invention is to provide a kind of applied widely, cost is low, resistance risk is low, to the bactericidal composition of anthracnose special efficacy.
Composite application is carried out in the combination of different pesticide active ingredient, is to solve agricultural chemicals list agent higher and easy a kind of effective means that produces problem such as resistance of cost when using at present.
The inventor has carried out the test of a large amount of compound screenings, unexpectedly finds dithianon and bromothalonil is composite that anthracnose of crop is had outstanding curative effect.
Bromothalonil (bromothalonil) is named the charcoal Trane again, stops the bacterium nitrile, is the bactericide of a kind of wide spectrum, efficient, low toxicity, can suppress and root out fungi, bacterium, algae grows, and corps diseases is had the better prevention effect, and anthracnose is had special efficacy.Adaptable across various crop such as fruit tree, grape, vegetables, cotton, peanut, watermelon, tobacco, tea tree, flowers, prevent and treat multiple fungoid, bacteroidal diseases such as anthracnose, scab, shot hole, powdery mildew, rust, damping off, damping off, root stem rot, canker, bacterial wilt, angular leaf spot.
Technical scheme of the present invention is:
A kind of bactericidal composition; It is characterized in that active ingredient is dithianon and bromothalonil; Wherein the weight ratio of dithianon and bromothalonil is 1: 80～80: 1; Preferable ratio is 1: 50～50: 1, and better ratio is 1: 30～30: 1, and the weight percentage of two kinds of active components is 1～95% in the composition., preferable content is 10～80%, optimum content is 20～60%.The content of active component depends on proportioning and the degree of synergistic effect each other;
Pesticide combination of the present invention can be prepared into known method and be fit to any one formulation that agricultural is used, and reasonable formulation is wetting powder, suspending agent, water dispersible granules, aqueous emulsion and microemulsion.The auxiliary agent that composition of the present invention uses comprises that solvent, dispersant, emulsifier, stabilizing agent, antifreezing agent, thickener etc. and other are of value to the known substance that active ingredient is stablized and drug effect is brought into play in preparation; All be the various compositions of using or allow use in the pesticidal preparations always; Do not have special qualification, concrete composition and consumption require to confirm through simple experiment according to prescription.
Bactericidal composition of the present invention can be applicable to prevent and treat fruit tree and vegetable crop disease, like the scab on apple, grape, strawberry, cucumber, capsicum, eggplant, tomato, Kidney bean, leek, Chinese cabbage, tobacco, rubber, oranges and tangerines, banana and some flowers, the lawn, mildew disease, leaf spot, anthracnose etc.
The characteristics and the beneficial effect of the present composition are:
1, synergistic effect is remarkable.The more single agent of mixed composition has obvious synergistic effect, improves control efficiency, has also enlarged the control spectrum; 2, the mechanism of action owing to two single agent in the composition is different fully, does not have mutual pesticide resistance, but so suspension of pesticide resistance generation.3, use cost reduces.Use the dithianon cost higher separately, two kinds of single agent are mixed, and cost obviously reduces under the prerequisite that guarantees drug effect.
Embodiment
In order to make the object of the invention, technical scheme and advantage clearer, the present invention describes with following specific embodiment, but the present invention is limited to these examples absolutely not.The following stated is merely the present invention embodiment preferably, only in order to explain the present invention, can not therefore be interpreted as the restriction to claim of the present invention.Should be pointed out that all any modifications of within spirit of the present invention and principle, being made, be equal to replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with accompanying claims.
Bactericidal composition of the present invention includes but not limited to following FORMULATION EXAMPLE:
1, wetting powder embodiment
Pesticide activity component dithianon and bromothalonil compound, auxiliary agent, filler are mixed the mixed again wetting powder that gets behind comminution by gas stream in proportion.Capital equipment: mixer, airslide disintegrating mill.
Embodiment 1:81% dithianon bromothalonil wetting powder
The withered powder of dithianon 1%, bromothalonil 80%, sodium lignin sulfonate 5%, tea 5%, draw back powder 1%, white carbon 1%, attapulgite and complement to 100%.
Embodiment 2:62% dithianon bromothalonil wetting powder
Dithianon 2%, bromothalonil 60%, sodium lignin sulfonate 2%, NNO2%, lauryl sodium sulfate 0.5%, bentonite 5%, diatomite complement to 100%.
2, suspending agent embodiment
Press formula rate, after dithianon and bromothalonil active component, surfactant, thickener, film forming agent, carrier or filler and the mixing of part water, through high speed shear, the wet method sand milling is processed semi-finished product, and moisturizing mixes filtration and promptly obtains finished product after analyzing.
Embodiment 3:31% dithianon bromothalonil suspending agent
Dithianon 30%, bromothalonil 1%, sodium lignin sulfonate 1%,, white carbon 2%, bentonite 2%, Magnesiumaluminumsilicate 1%, ethylene glycol 5%, water complement to 100%.
Embodiment 4:51% dithianon bromothalonil suspending agent
Dithianon 1%, bromothalonil 50%, sodium lignin sulfonate 1%,, white carbon 2%, bentonite 2%, Magnesiumaluminumsilicate 1%, ethylene glycol 5%, water complement to 100%.
Embodiment 5:45% dithianon bromothalonil suspending agent
Dithianon 15%, bromothalonil 30%, sodium lignin sulfonate 1%,, white carbon 2%, bentonite 2%, Magnesiumaluminumsilicate 1%, ethylene glycol 5%, water complement to 100%.
3, the processing of microemulsion, aqueous emulsion and embodiment
By each set of dispense ratio, in solvent and cosolvent, the adding surfactant mixes and makes oil phase with dithianon and bromothalonil solubilization of active ingredient.With water-soluble component and the mixed water that gets of water, again oil phase is added in aqueous phase or the water adding oil phase, the limit edged stirs, and makes microemulsion or aqueous emulsion.
Embodiment 6:2% dithianon bromothalonil microemulsion
Dithianon 0.5%, bromothalonil 1.5%, DMF10%, xylol 10%, propane diols 5%, castor oil polyoxyethylene ether 8%, calcium dodecyl benzene sulfonate 3%, water complement to 100%.
Embodiment 7:15% dithianon bromothalonil aqueous emulsion
Dithianon 5%, bromothalonil 10%, DMF5%, cyclohexanol 10%, glycerine 5%, phenethyl phenol polyethenoxy ether 10%, agricultural newborn 500#5%, water complement to 100%.
4 water-dispersible granules embodiment
Pesticide activity component dithianon and bromothalonil compound, auxiliary agent and filler are mixed in proportion,, add the water of 15-20% then, make the water dispersible granules product through kneading, granulation, drying, screening through comminution by gas stream.Capital equipment: mixer, airslide disintegrating mill, kneader, Squeezinggranulator, drying equipment (drying room or fluid bed).
Embodiment 8:40.5% dithianon bromothalonil water dispersible granules
Dithianon 40%, bromothalonil 0.5%, sodium lignin sulfonate 5%, methyl naphthalene sulfonate formaldehyde condensate 15%, lauryl sodium sulfate 5%, sodium alginate 5%, potter's clay complement to 100%.
Embodiment 9:51% dithianon bromothalonil water dispersible granules
The withered powder of dithianon 50%, bromothalonil 1%, sodium lignin sulfonate 5%, tea 2%, lauryl sodium sulfate 2%, sodium carboxymethyl starch 2%, bentonite complement to 100%.
The biological activity test example:
1: dithianon and bromothalonil are composite to the apple anthrax bacteria Toxicity Determination
Subjects: apple anthrax bacteria (picking up from the field) through three purifies and separates
Test method: with reference to " the agricultural industry criteria NY/T1156.2-2006 of the People's Republic of China (PRC) " and " the agricultural industry criteria NY/T1156.6-2006 of the People's Republic of China (PRC) " mycelial growth rate method.Apple anthrax bacteria is used the PDA medium culture, when treating that bacterium colony has just covered with culture dish, use internal diameter to punch from the edge as the card punch of 7mm, the mycelia piece that breaks into is as inoculum.Get the soup 5mL for preparing and quantitative 75mL sterilising medium respectively and mix, process 4 pastille flat boards, be mixed into contrast with equivalent sterile water and medium.The inversion of mycelia piece is connected to dull and stereotyped central authorities, and in 28 ℃ of incubators, cultivates.Behind the 7d, measure colony diameter, calculate and respectively handle the clean amount of growth of bacterium colony, mycelial growth inhibition rate with the right-angled intersection method.
The clean amount of growth of bacterium colony (mm)=measurement colony diameter-7
Mycelial growth rate (%)=[(the clean amount of growth of the control group bacterium colony-clean amount of growth of processed group bacterium colony)/clean amount of growth of control group bacterium colony] * 100
The mycelial growth rate conversion is become probability value (y), and liquor strength (μ g/ml) converts logarithm value (x) to, concentration EC in calculating the virulence equation and suppress with method of least squares
50, according to the toxicity index and the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun medicament.
Actual measurement toxicity index (ATI)=(standard medicament EC
50/ confession reagent agent EC
50) * 100
The percentage composition of B in percentage composition+B medicament toxicity index * mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] * 100
When CTC≤80, then the composition performance is antagonism; When 80＜CTC＜120, then the composition performance is summation action; When CTC>=120, then the composition performance is synergistic effect.
Result's (table 1) shows that dithianon and bromothalonil are between proportioning 1: 80～80: 1, and co-toxicity coefficient all more than 120, has synergistic effect to apple anthrax bacteria, and especially between 1: 30～30: 1, co-toxicity coefficient is more than 200.
The composite Toxicity Determination result of table 1 dithianon and bromothalonil to apple anthrax bacteria
| Handle | EC 50(μg/mL) | ATI | TTI | Co-toxicity coefficient CTC |
| Dithianon | 2.536 | 100 | / | / |
| Bromothalonil | 3.822 | 66.35 | / | / |
| Dithianon 1: bromothalonil 80 | 4.715 | 81.06 | 66.77 | 121.41 |
| Dithianon 1: bromothalonil 50 | 4.167 | 113.15 | 67.01 | 168.86 |
| Dithianon 1: bromothalonil 30 | 2.987 | 139.50 | 67.44 | 206.87 |
| Dithianon 1: bromothalonil 5 | 2.003 | 149.13 | 71.96 | 207.24 |
| Dithianon 1: bromothalonil 1 | 1.121 | 178.68 | 83.18 | 214.82 |
| Dithianon 1: bromothalonil 10 | 0.776 | 144.46 | 69.41 | 208.13 |
| Dithianon 30: bromothalonil 1 | 0.384 | 202.08 | 98.91 | 204.30 |
| Dithianon 50: bromothalonil 1 | 0.231 | 166.23 | 99.34 | 167.34 |
| Dithianon 80: bromothalonil 1 | 0.186 | 124.19 | 99.58 | 124.71 |
The field control effectiveness test example:
Dithianon and bromothalonil composition are to the field control effectiveness test of apple anthracnose
Fall ill heavier orchard as the test site with long-term apple anthracnose, and repeat 4 sub-districts of every processing, each sub-district two strains tree.Each chemicals treatment and dosage see table 2 for details.After treating the apple result, respectively in May 16, May 26, September 17, each spray is once used the hand-rail type high-pressure sprayer, and it is evenly thoughtful that soup is sprayed onto full tree, is degree there to be medicine liquid droplet to fall, and uses the flushing with clean water apparatus before changing dressings at every turn.Respectively handle the fruit number and sense anthracnose fruit number of sub-district complete stool in the investigation before gather of anthracnose their early stage, calculate decayed fruit rate and relative control effect.
Decayed fruit rate (%)=(each sub-district decayed fruit quantity/each all fruit quantity of sub-district investigation) * 100
Definition: the difference of decayed fruit rate was a before the contrast clear water was used the back and used; After each sub-district dispenser with dispenser before the difference of decayed fruit rate be b
Preventive effect (%)=(a-b) * 100/a
Table 2 dithianon and bromothalonil composition are to apple anthracnose field control effectiveness test result
| Supply the reagent agent | Dosage (ga.i./ha) | Decayed fruit rate (%) before the medicine | Decayed fruit rate (%) behind the medicine | Preventive effect (%) |
| 22.7% dithianon suspending agent | 200 | 0.2 | 4.98 | 76.71 |
| 25% bromothalonil wetting powder | 250 | 0.18 | 6.21 | 70.61 |
| Embodiment 1 | 220 | 0.16 | 3.65 | 82.99 |
| Embodiment 2 | 220 | 0.17 | 2.55 | 88.40 |
| Embodiment 3 | 200 | 0.15 | 2.42 | 88.94 |
| Embodiment 4 | 220 | 0.16 | 3.36 | 84.41 |
| Embodiment 5 | 220 | 0.17 | 2.18 | 90.20 |
| Embodiment 6 | 220 | 0.15 | 2.07 | 90.64 |
| Embodiment 7 | 220 | 0.12 | 1.98 | 90.94 |
| Embodiment 8 | 200 | 0.14 | 3.87 | 81.82 |
| Embodiment 9 | 200 | 0.16 | 3.23 | 85.04 |
| Ck (clear water) | ---- | 0.16 | 20.68 | / |
Ga.i./ha: expression per hectare active ingredient gram number
From last table, can find out dithianon and bromothalonil bactericidal composition; Be equal to or less than in the unit are dosage under the situation of corresponding single agent, the control apple anthracnose, control efficiency is obvious; Particularly when dithianon and bromothalonil ratio are composite between 1: 30～30: 1 (embodiment 2,3,5,6,7); Preventive effect is particularly outstanding, reaches more than 87%, this shows that dithianon and bromothalonil bactericidal composition have synergistic function aspect the treatment apple anthracnose.
In sum, be the present composition of active ingredient with dithianon and bromothalonil, have the characteristics of efficient, low toxicity, low resistance risk, be applicable to the fungal disease of control fruit tree, vegetables and other crops.
Claims (5)
1. bactericidal composition, it is characterized in that: active component is dithianon and bromothalonil in the composition, and wherein the ratio of weight and number of dithianon and bromothalonil is 1: 80～80: 1, the weight percentage of two kinds of active components is 1～95% in the composition.
2. bactericidal composition according to claim 1 is characterized in that: the ratio of weight and number of dithianon and bromothalonil is 1: 50～50: 1 in the composition, and the weight percentage of two kinds of active components is 10～80% in the composition.
3. bactericidal composition according to claim 2 is characterized in that: the ratio of weight and number of dithianon and bromothalonil is 1: 30～30: 1 in the composition, and the weight percentage of two kinds of active components is 20～60% in the composition.
4. according to each described bactericidal composition in the claim 1 to 3, it is characterized in that: the formulation of said bactericidal composition is any one in wetting powder, suspending agent, water dispersible granules, aqueous emulsion, the microemulsion.
5. the described bactericidal composition of claim 1 purposes that is used to prevent and treat apple anthracnose.
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