CN101711672A - Method for acquiring detailed physiological information of testee in magnetic resonance imaging - Google Patents
Method for acquiring detailed physiological information of testee in magnetic resonance imaging Download PDFInfo
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- CN101711672A CN101711672A CN200910303538A CN200910303538A CN101711672A CN 101711672 A CN101711672 A CN 101711672A CN 200910303538 A CN200910303538 A CN 200910303538A CN 200910303538 A CN200910303538 A CN 200910303538A CN 101711672 A CN101711672 A CN 101711672A
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Abstract
The invention belongs to the technical field of magnetic resonance imaging, and particularly provides a method for acquiring detailed physiological information of a testee in magnetic resonance imaging, which can synchronously acquire all aspects of physiological information of the testee during magnetic resonance imaging data acquisition. The method comprises the following steps: firstly, recording real-time signals of a screen during data acquisition, acquiring a physiological information video file, reading the width, height and information header structural information of each frame of images according to the video file, then reading each frame of images from the video file, acquiring physiological signals of one time period from each frame of images, and finally combining the physiological signals to form physiological information data of whole scanning process. The method is simple and reliable, and can effectively record and search the detailed physiological information of the testee to be used as clinical references without adding any hardware.
Description
Technical field
The invention belongs to the technical field of nuclear magnetic resonance, concrete be meant a kind of method of obtaining detailed physiological information of testee in the nuclear magnetic resonance that is applicable to.
Background technology
Nuclear magnetic resonance has characteristics such as not damaged, soft tissue contrast height, any direction tomography, has been widely used in medical clinic applications at present, and functional mri (fMRI) is the new technique that occurs along with the development of magnetic resonance fast imaging technology.In recent years, functional mri technology based on blood oxygenation level dependent (BOLD) is carrying out having obtained development rapidly aspect the brain function research, it becomes one of important means to live body brain function physiology, pathology active studies gradually with all higher advantage of room and time resolution.
What classical functional mri was studied is that the relevant brain of task activates, and shown function brain district draws after being subtracted each other by the contrast state of task status and no task in the research.And recent discovering, even under clear-headed quiescent condition of closing one's eyes, human brain also exists functional activity.There is the spontaneity vibration or the fluctuation of low frequency in tranquillization attitude functional mri signal, away from two brain districts between have the synchronicity of time, be positioned at the frequency interval of 0.1Hz.Extensively the viewpoint of approval is at present: there is the default feature network in human brain under quiescent condition, i.e. cingule gyrus posterior cortex, precuneus, the inboard cortex of prefrontal lobe.
The research of quiescent condition cerebration is the focus of cerebral function imaging research in recent years, and it has proposed challenge to some result of cerebral function imaging research in the past.Former studies all is with the quiescent condition of no task in contrast, because there is cerebration in brain equally at quiescent condition, with this in contrast, obviously will exert an influence to experimental result.Therefore only know about the essence and the rule of quiescent condition cerebration, could more reasonably explain result of experiment, design more scientifically experimentizes.The quiescent condition cerebration itself has the important physical meaning, and it is closely related with critical functions such as human self consciousness and episodic memorys.Need further dark people to study the network structure and the functional characteristics of tranquillization attitude cerebration, it will have impetus to the research of the senior consciousness of human brain and some cognitive illnesses.Research to this tranquillization attitude default feature network has in recent years obtained remarkable progress.Researcher utilizes different analytical methods to study the characteristic of activities in patients' such as Alzheimer, auditory hallucination, attention-deficit hyperactivity syndrome, schizophrenia, epilepsy tranquillization attitude default feature brain district, has drawn the viewpoint that has unusual default feature network.
Therefore but some physiological movements of human body as heart beating and breathing etc., also can cause the low-frequency fluctuation of magnetic resonance imaging signal, and it is extremely important to distinguish the signal that spontaneous functional activity of human brain and physiological movement cause.In order to reach this target, must when graphical analysis, utilize these physiological movement signal messages to eliminate the influence of physiological movement then at the detailed signal data of the synchronous acquisition physiological activity of gathering tranquillization attitude magnetic resonance imaging data to functional magnetic resonance signal.In addition, the method that has some to eliminate motion artifacts in the nuclear magnetic resonance also needs to obtain the detailed waveform of physiological movement signal.But in general commercial magnetic resonance imaging system, only provide the real-time demonstration of physiological signal, the itemized record of the physiological signal in the whole scanning process can not be provided.
Summary of the invention
The objective of the invention is provides the method for obtaining detailed physiological information of testee in a kind of nuclear magnetic resonance at above-mentioned the deficiencies in the prior art part, can obtain the detailed physiologic information of tested each side when magnetic resonance imaging data is gathered synchronously.
The object of the invention realizes being finished by following technical scheme:
Technical scheme of the present invention comprises data acquisition and two aspects of data analysis processing:
Obtain the method for detailed physiological information of testee in a kind of nuclear magnetic resonance, at first when data acquisition, record the screen live signal, collect the physiologic information video file, read the information header structural information of wide, high, every two field picture of every two field picture according to video file, from video file, read each two field picture then, obtain the physiological signal of section sometime from each two field picture again, be combined into the physiologic information data of whole scanning process at last.
The step of above-mentioned data acquisition is:
(1) tested enter magnet before, place corresponding physiology monitor sniffer in tested health specific part;
(2) on screen, show physiologic information in real time;
(3) when gathering magnetic resonance imaging data, startup screen is recorded software synchronously, gathers the physiologic information video that shows in real time;
(4) after the magnetic resonance imaging data collection is finished, stop screen video and record;
(5) the corresponding video of recording is preserved hereof.
The concrete implementation step of the described physiological signal that obtains sometime section from each two field picture is as follows:
(1) reads each frame image information;
(2) the physiologic information signal that obtains obtaining is presented at the scope of the longitudinal axis;
(3) characteristics that show according to waveform obtain the coordinate of every bit on the wavy curve;
(4) obtain the concrete numerical data of the physiological signal of each time point according to described coordinate, i.e. the time sequence information of waveform.
The concrete implementation step of the described physiologic information that is combined into whole scanning process is as follows:
(1) reads the time sequence information of the waveform in each stage;
(2) shape information of adjacent period is carried out registration;
(3) combination obtains into the time sequence information of the physiological signal of whole scanning process, adopts average for lap.
Advantage of the present invention is that method is simple, reliable, need not to add any hardware, can effectively write down, detect detailed physiological information of testee, as clinical reference.
Description of drawings
Fig. 1. the ecg wave form that obtains from a certain frame video image among the embodiment;
Fig. 2. the ecg wave form of the physiologic information data of the whole scanning process that combination obtains among the embodiment;
Fig. 3. the ecg wave form of the physiologic information data of the whole scanning process that combination obtains among the embodiment;
The specific embodiment
Feature of the present invention and other correlated characteristic are described in further detail by embodiment below in conjunction with accompanying drawing, so that technical staff's of the same trade understanding:
Present embodiment is to obtain the ecg wave form details from magnetic resonance imaging system, and the magnetic resonance imaging system that is adopted is a Siemens 3.0T magnetic resonance imaging system, and model is: MAGNETOM Trio TIM, software version is: VB15.The magnetic resonance imaging data of present embodiment collection is tranquillization attitude functional mri data.
The method that present embodiment adopts is by recording the screen live signal, collect the physiologic information video file, carry out date processing according to video file then, obtaining the detailed physiologic information data of whole scanning process at last.
The collecting method that adopts is: (1) tested enter magnet before, place corresponding cardiac diagnosis lead and electrocardioelectrode in tested chest; (2) on nuclear magnetic resonance main frame screen, show electrocardio ECG signal waveform in real time; (3) when gathering magnetic resonance imaging data, startup screen is recorded software synchronously, gathers the physiologic information video that shows in real time, and video acquisition speed was 5 frame/seconds in the present embodiment; (4) after the magnetic resonance imaging data collection is finished, stop screen recording; (5) the corresponding video of recording is preserved hereof, the storage format of video file is AVI in the present embodiment.
The magnetic resonance imaging data of above-mentioned collection is tranquillization attitude functional mri data, tested close one's eyes and eupnea lie in the middle of the magnet, the pulse train of scanning is gtadient echo EPI sequence.
Data analysis processing method is: (1) reads the information such as information header structure of wide, high, every two field picture of every two field picture according to the avi file header, and wide in the present embodiment is 476 pixels, and height is 480 pixels; (2) from avi file, read each two field picture, as shown in Figure 1; (3) obtain the physiological signal data of certain hour section from each two field picture, (abscissa is the time, and vertical coordinate is wave-shape amplitude relative value) as shown in Figure 2; (4) be combined into the physiologic information data of whole scanning process, as shown in Figure 3, wherein abscissa is the time, and vertical coordinate is wave-shape amplitude relative value.
The concrete steps in the 3rd step " obtaining the physiological signal of certain hour section from each two field picture " are as follows in the above-mentioned data analysis processing method: (1) reads each frame image information; (2) the physiologic information signal that obtains obtaining is presented at the scope of the longitudinal axis; (3) characteristics that show according to waveform obtain the coordinate of every bit on the wavy curve; (4) obtain the concrete numerical data of the physiological signal in each stage according to above-mentioned coordinate, i.e. the time sequence information of waveform.
Above-mentioned the 4th step " being combined into the physiologic information of whole scanning process " concrete steps are as follows:
(1) reads the time sequence information of the waveform in each stage; (2) shape information of adjacent period is carried out registration; (3) combination obtains into the time sequence information of the physiological signal of whole scanning process, adopts average for lap.
AFNI software is adopted in the processing of tranquillization attitude functional MRI data among the embodiment, and processing procedure comprises data pretreatment and two steps of data analysis.The data pretreatment is mainly carried out a dynamic(al) correction, space criteriaization, space smoothing, the time signal curve is carried out low frequency filtering data.Data analysis mainly is an average signal strength of extracting seed zone, then itself and complete each picture element signal of brain is carried out Linear correlative analysis, and the seed zone of present embodiment setting is to return primary motor cortex before the left brain Rolandic fissure.The tranquillization attitude functional associated map interlinking of Fig. 4 for not adopting the physiology waveform correction to obtain, the functional associated map interlinking of tranquillization attitude that obtains behind the physiology waveform information correction of Fig. 5 for employing the present invention acquisition.As can be seen from Fig. 5: by the physiology waveform information correction of the present invention's acquisition, therefore some obtain deriving from more accurately the functional associated map interlinking of human brain default feature network because the magnetic resonance signal relevant connection that physiological movement causes (circle is interior among Fig. 4) just has been filtered.
Claims (4)
1. obtain the method for tested physiologic information in the nuclear magnetic resonance, it is characterized in that at first when data acquisition, collect the physiologic information video file by recording the real-time physiological signal of screen, read the information header structural information of wide, high, every two field picture of every two field picture then according to video file, and from video file, read each two field picture, obtain the physiological signal of section sometime from each two field picture again, be combined into the physiologic information data of whole scanning process at last.
2. obtain the method for detailed physiological information of testee in a kind of nuclear magnetic resonance shown in claim 1, it is characterized in that the concrete steps of described data acquisition are:
(1) tested enter magnet before, place corresponding physiology monitor sniffer in tested health specific part;
(2) on screen, show physiologic information in real time;
(3) when gathering magnetic resonance imaging data, startup screen is recorded software synchronously, gathers the physiologic information video that shows in real time;
(4) after the magnetic resonance imaging data collection is finished, stop screen video and record;
(5) the corresponding video of recording is preserved hereof.
3. obtain the method for detailed physiological information of testee in a kind of nuclear magnetic resonance shown in claim 1, it is characterized in that the concrete implementation step of the described physiological signal that obtains sometime section from each two field picture is as follows:
(1) reads each frame image information;
(2) the physiologic information signal that obtains obtaining is presented at the scope of the longitudinal axis;
(3) characteristics that show according to waveform obtain the coordinate of every bit on the wavy curve;
(4) obtain the concrete numerical data of the physiological signal of each time point according to described coordinate, i.e. the time sequence information of waveform.
4. obtain the method for detailed physiological information of testee in a kind of nuclear magnetic resonance shown in claim 1, it is characterized in that the concrete implementation step of the described physiologic information that is combined into whole scanning process is as follows:
(1) reads the time sequence information of the waveform in each stage;
(2) shape information of adjacent period is carried out registration;
(3) combination obtains into the time sequence information of the physiological signal of whole scanning process, adopts average for lap.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101966081A (en) * | 2010-08-05 | 2011-02-09 | 华东师范大学 | Method for correcting influence of breathing information on resting state function magnetic resonance brain imaging |
| CN112649773A (en) * | 2020-12-22 | 2021-04-13 | 上海联影医疗科技股份有限公司 | Magnetic resonance scanning method, device, equipment and storage medium |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101966081A (en) * | 2010-08-05 | 2011-02-09 | 华东师范大学 | Method for correcting influence of breathing information on resting state function magnetic resonance brain imaging |
| CN112649773A (en) * | 2020-12-22 | 2021-04-13 | 上海联影医疗科技股份有限公司 | Magnetic resonance scanning method, device, equipment and storage medium |
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