CN101703620B - Externally applied medicament for treating vitiligo - Google Patents
Externally applied medicament for treating vitiligo Download PDFInfo
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- CN101703620B CN101703620B CN2009101727991A CN200910172799A CN101703620B CN 101703620 B CN101703620 B CN 101703620B CN 2009101727991 A CN2009101727991 A CN 2009101727991A CN 200910172799 A CN200910172799 A CN 200910172799A CN 101703620 B CN101703620 B CN 101703620B
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Abstract
The invention provides an externally applied medicament for treating vitiligo, which relates to medicaments for treating vitiligo. The medicament consists of dark plum fruits, angelica dahurica roots, green husk, green walnut shells, lithospermum, Chinese arborvitae twig, malaytea scurfpea fruits, green eggplant, Chinese ilex leaves, Chinese dodder seeds, clobetasol propionate, laurocapram, chloroform and 90 percent alcohol. A making process comprises: a, soaking the dark plum fruits and the other 10 raw materials in alcohol for 5 to 7 days and forming Chinese medicinal liquid through filtration; b, dissolving clobetasol propionate with chloroform; c, adding clobetasol propionate solution and laurocapram to the Chinese medicinal liquid; and d, adding distilled water for dilution. In general, the raw medicinal materials cooperate to improve immunity by expanding blood vessels, releasing toxin and dispelling wind; brown pigment of the medicament is fully utilized and absorbed; tyrosinase is generated by stimulating skin so as to regenerate pigment; and the pigment is stabilized through allergy resistance. The medicament has the advantages of capability of treating both primary and secondary symptoms, rapid efficacy, safety, reliability, using convenience and good therapeutic effects. 110 clinical trials show that the total effective rate of the medicament reaches 94.5 percent.
Description
Technical field:
The present invention relates to medicine, further is to be used for the treatment of leukodermic medicine, is particularly useful for treating leukodermic liniment.
Background technology:
Vitiligo claims white macula wind again, and the vitiligo disease is that a kind of common multiple, acquired, the special property sent out skin pigment takes off the mistake disease, and diagnosis is difficult to treatment easily.This disease can start from all age group, and whole body skin everywhere all can take place.Vitiligo is common in adolescence, and is most less than 20 years old.Generally vitiligo is divided into topical type, distributes type, general hair style, segmental pattern and face acra type, the treatment of back three kinds of types is then more difficult.Be divided into progressive stage, stable phase and upward swing by the state of an illness.Progressive stage,, white macula easily produced isomorphic response, the new white macula of secondary.The primary disease cause of disease it be unclear that, and it is generally acknowledged with psychology, diet, vitamin, life habit relevant.Modern medicine thinks that its morbidity is the individuality with heredodiathesis, shows as the disorder of nerve, spirit, immunologic function and endocrine metabolism under the exciting of multiple internal and external factor.Cause the inhibition of enzyme system or the destruction of melanocyte at last, thereby cause leukodermic generation.
Vitiligo is not only a kind of dermatosis, also seriously influences patient's physical and mental health, and the lighter influences work. and family, weight person make part patient misery, despair, even produce the thought of committing suicide.The leukodermic medicine of multiple treatment is arranged in the market, and effect has nothing in common with each other, and does not still have specific medicament.Study new effective therapy of vitiligo medicine for external use, imperative.
Summary of the invention:
Purpose of the present invention is exactly the defective that exists in the existing Drug therapy, and a kind for the treatment of both the principal and secondary aspects of a disease, drug effect is rapid, safe and reliable, easy to use, therapeutic effect the is good leukodermic medicine for external use of treatment are provided.
The objective of the invention is to realize: the leukodermic medicine for external use of a kind of treatment by following scheme, it is characterized in that by comprising that following material forms: Fructus Mume 130-170 gram, Radix Angelicae Dahuricae root 50-70 gram, green Pericarpium Granati 50-70 gram, Exocarpium Juglandis Immaturus 50-70 gram, Radix Arnebiae (Radix Lithospermi) 30-50 gram, Cacumen Platycladi 80-100 gram, Fructus Psoraleae (smashing to pieces) 110-130 gram, green Fructus Solani melongenae 260-340 gram, Folium Ilicis Purpureae 110-130 gram, Semen Cuscutae 80-100 gram, clobetasol propionate 0.1-0.3 gram, laurocapram 15-25 milliliter, chloroform 15-25 milliliter, 90% ethanol 750-850 milliliter.
Preferred version is: Fructus Mume 140-160 gram, Radix Angelicae Dahuricae root 55-65 gram, green Pericarpium Granati 55-65 gram, Exocarpium Juglandis Immaturus 55-65 gram, Radix Arnebiae (Radix Lithospermi) 35-45 gram, Cacumen Platycladi 85-95 gram, Fructus Psoraleae (smashing to pieces) 115-125 gram, green Fructus Solani melongenae 280-320 gram, Folium Ilicis Purpureae 115-125 gram, Semen Cuscutae 85-95 gram, clobetasol propionate 0.1-0.3 gram, laurocapram 18-22 milliliter, chloroform 18-22 milliliter, 90% ethanol 780-820 milliliter.
Preferred plan is: Fructus Mume 150 grams, Radix Angelicae Dahuricae root 60 grams, green Pericarpium Granati 60 grams, Exocarpium Juglandis Immaturus 60 grams, Radix Arnebiae (Radix Lithospermi) 40 grams, Cacumen Platycladi 90 grams, Fructus Psoraleae (smashing to pieces) 120 grams, green Fructus Solani melongenae 300 grams, Folium Ilicis Purpureae 120 grams, Semen Cuscutae 90 grams, clobetasol propionate 0.2 gram, 20 milliliters of laurocapram, 20 milliliters of chloroform, 800 milliliters of 90% ethanol.
Manufacture method: a elder generation with alcohol-pickled 5-7 days, filters Fructus Mume, Radix Angelicae Dahuricae root, green Pericarpium Granati, Exocarpium Juglandis Immaturus, Radix Arnebiae (Radix Lithospermi), Cacumen Platycladi, Fructus Psoraleae (smashing to pieces), green Fructus Solani melongenae, Folium Ilicis Purpureae, Semen Cuscutae, forms traditional Chinese medicine liquid, and is stand-by; B dissolves propanoic acid chlorine third his rope with chloroform; C adds his rope lysate of propanoic acid chlorine third and laurocapram in the traditional Chinese medicine liquid; D adds distilled water diluting (distilled water 150-250 milliliter is added in the medicinal liquid); E bottling sterilization is stand-by.
Configuration mechanism of the present invention: Fructus Mume has antiallergic, resisting fatigue, radioprotective, anti-aging effects, antitumor action, inhibition variation effect, immunologic function potentiation, antivirus action.Radix Angelicae Dahuricae root contains multiple furocoumarin compounds, and antibacterial blood vessel dilating effect is arranged, and the effect of the diffusing wind that induces sweat being arranged.Pericarpium Granati has the regenerated effect of the brown pigment of promotion after the illumination.Cortex walnut is the peel of juglandaceae plant Semen Juglandis, contains various organic acid brown pigment fertile absorbers.Radix Arnebiae (Radix Lithospermi) has antiinflammatory, anticancer, anti-microbial effect.Cacumen Platycladi contains various trace elements, and the antibacterial anti hemorrhagic effect is arranged.Fructus Psoraleae has the expansion blood vessel, and leukocyte increasing is antibiotic, photosensitization.Folium Ilicis Purpureae, containing a large amount of is the pigment forebody, can the regeneration of Ci Ji Network propylhomoserin enzyme.Semen Cuscutae contains courage sterol, campesterol, sitosterol etc. and triterpene acid, also contains elements such as calcium, chromium, manganese, ferrum, zinc simultaneously, and certain immunological enhancement is arranged.His rope (having another name called dermovate) of propanoic acid chlorine third, potent steroid hormone can make pigment regeneration, and the antiinflammatory anti-allergic effects is arranged.Chloroform (having another name called chloroform) is transparency liquid, has after corrosivity, polymerism, photonasty and sodium mixes, and blasts easily after the judder, is exposed to for a long time under the daylight, decomposes slowly, and it dissolves dermovate.Laurel nitrogen copper, can with most Organic substance mixings, stable in properties mainly promotes transdermal to absorb.Generally, each medicine is made a concerted effort, and by blood vessel dilating, the diffusing wind of detoxifcation improves immunity, and the brown pigment of medicine is made full use of absorption, makes pigment regeneration by chafe Chan Sheng Network propylhomoserin enzymic again, cooperates with antiallergic to make pigment stable again.
The invention has the beneficial effects as follows: medicine of the present invention, treating both the principal and secondary aspects of a disease, drug effect is rapid, safe and reliable, easy to use, curative effect is preferable.Show that with 110 routine clinical trials total effective rate reaches 94.5%.
Testing data:
1, cures mainly: vitiligo.
2, Therapeutic Method: this medicine is used for the limitation vitiligo, is coated with twice in 1st.Day illumination was shone 5 minutes after all advising its coating.
3, contraindication: period in a medicine, avoid eating anything raw or cold, pungent greasy, stodgy food.Gravid woman and women breast-feeding their children's forbidding are forbidden this product allergy sufferers.
4, efficacy assessment standard:
The method of curative effect assessment is, complete obiteration in 3 months is recovery from illness, and disappearing be produce effects 80% or more, and disappearance 30%-80% is effective, and disappearance is invalid below 30%.
5, therapeutic effect:
Make a definite diagnosis patient's 110 examples through Hua County Qin Jian institute of internal medicine, 70 people below 20 years old, 40 people more than 20 years old.Be the limitation vitiligo, facial skin lesion patient 66 people, extremity patient 31 people, metastomium patient 13 people.The elder of medical history 4 years, the shortest person of medical history 6 months.All observe inactive all the other therapeutic schemes of patient.Observe finding after January, 4 people that fully recover are 20 years old with the lower face patient.Obvious person 16 people of effect account for 11 people below 20 years old, account for 5 people more than 20 years old.After 2 months, recovery from illness patient 19 people account for 11 people below 20 years old, account for 8 people more than 20 years old, facial patient 13 people, extremity patient 4 people, trunk patient 2 people.After 3 months, observe finding, recovery from illness patient 62 people account for and account for 49 people below 56.4%, 20 years old, account for 13 people more than 20 years old, facial patient 33 people, and extremity patient 14 people, trunk patient 15 people, obvious person 23 people of effect account for 20.9%; Responder 19 people account for 17.3%, and nonresponder 6 people account for 5.5%.Total effective rate 94.5%.
The result shows that medical history weak point person is long more effective than medical history, and facial patient's effect is better than extremity patient, and extremity patient effect is more effective than metastomium, below 20 years old than effective more than 20 years old.During the treatment, have 9 people slight irritation to occur, no blister does not have red and swollen.This scheme of synthesis result is safe and effective.
5, model case introduction:
(1) goes into business so-and-so, man, 12 years old, student, people from Guzhen stayed in Hua County in Henan Province, and facial white macula 1 year of finding has country doctor to be diagnosed as " pityriasis simplex ", fails to respond to any medical treatment, go to Kaifeng to go to a doctor, be diagnosed as vitiligo, unsatisfactory curative effect comes to go to a doctor, advise 20 milliliters of its oral zinc sulfate oral liquids twice, a time on the one, the external white rehabilitation liniment of dispelling, twice on the one, further consultation after January, most of white macula disappears, and white trace mays be seen indistinctly, after useful January, the further consultation recovery from illness is followed up a case by regular visits to and is not had recurrence so far.
(2) Qin so-and-so, woman, 16 years old, the student, the burnt brave village people in Hua County, Henan Province, face, 6 of extremity finger tip white maculas 6 months are failed to respond to any medical treatment in local clinic and to be examined, and ask its no family history, often flu was advised its oral transfer factor one day twice, once two, 20 milliliters of zinc sulfate oral liquids twice on the one one time, the external external white rehabilitation liniment of dispelling, twice on the one, the only surplus a slice of further consultation after January, face does not heal the finger tip poor effect.Scheme is constant, further consultation after February, white patch on the face disappears, finger tip takes a turn for the better to some extent, again logotype the bimester after, recovery from illness.So far still there is not recurrence.
(3) Zhang, the man, 22 years old, the Zhengzhou university student, when playing basketball after the wound white macula 1 year surplus, the Zhengzhou hospitalize is invalid February, introduces me to go to a doctor through others, gives the external external white rehabilitation liniment of dispelling, and one day twice, fully recovers after January.
(4) Zhang, woman, 19 years old, the student, road junction, Hua County people from town, its brother treated afterwards and examined, its waist right side Semen Juglandis sample size white macula half a year, advised its oral transfer factor one day twice, once two, 20 milliliters of zinc sulfate oral liquids twice on the one one time, the external external white rehabilitation liniment of dispelling, twice on the one, day illumination was shone 3 minutes after advising its coating, tell behind the first quarter moon and excitement, do not have redness, no pimple, the belt friction is relevant after considering coating, continue medication, further consultation after January, there is pigment regeneration the centre, scheme is constant, be almost recovered after February, probably its recurrence continues medication after treatment in January.
(5) Yang, man, 36 years old, area just outside a city gate town, Hua County, Henan Province peasant, metastomium, extremity near-end white macula 6 years, through multi-treatment, poor effect is introduced through its friend and to be examined, patient is because of suffering from vitiligo marriage failure, and mental pressure is very big, according to its state of an illness, oral vifiligo pill, vitamin B2, doxepin, transfer factor capsule, the external external external white rehabilitation liniment of dispelling, twice on the one, day illumination was shone 3 minutes after advising its coating, and further consultation after January has the part stain to occur, indivedual little skin lesion disappear, and scheme is constant, continue medication, the further consultation in January is arranged, and basic 50% recovery from illness has not had pressure at heart, former scheme is constant, adds to use the methoxsalen sheet, is almost recovered after April.
The specific embodiment:
Below in conjunction with embodiment the present invention is done further narration:
Embodiment 1: select Fructus Mume 140 grams, Radix Angelicae Dahuricae root 55 grams, green Pericarpium Granati 55 grams, Exocarpium Juglandis Immaturus 55 grams, Radix Arnebiae (Radix Lithospermi) 35 grams, Cacumen Platycladi 85 grams, Fructus Psoraleae (smashing to pieces) 115 grams, green Fructus Solani melongenae 280 grams, Folium Ilicis Purpureae 115 grams, Semen Cuscutae 85 grams, clobetasol propionate 0.1 gram, 18 milliliters of laurocapram, 18 milliliters of chloroform, 780 milliliters of 90% ethanol.During making, a elder generation with alcohol-pickled 5-7 days, filters Fructus Mume, Radix Angelicae Dahuricae root, green Pericarpium Granati, Exocarpium Juglandis Immaturus, Radix Arnebiae (Radix Lithospermi), Cacumen Platycladi, Fructus Psoraleae (smashing to pieces), green Fructus Solani melongenae, Folium Ilicis Purpureae, Semen Cuscutae, forms traditional Chinese medicine liquid, and is stand-by; B dissolves propanoic acid chlorine third his rope with chloroform; C adds his rope solution of propanoic acid chlorine third and laurocapram in the traditional Chinese medicine liquid; D adds 180 milliliters of distilled water in the medicinal liquid; E bottling sterilization is stand-by.
Embodiment 2: select Fructus Mume 160 grams, Radix Angelicae Dahuricae root 65 grams, green Pericarpium Granati 65 grams, Exocarpium Juglandis Immaturus 65 grams, Radix Arnebiae (Radix Lithospermi) 45 grams, Cacumen Platycladi 95 grams, Fructus Psoraleae (smashing to pieces) 125 grams, green Fructus Solani melongenae 320 grams, Folium Ilicis Purpureae 125 grams, Semen Cuscutae 95 grams, clobetasol propionate 0.3 gram, 22 milliliters of laurocapram, 22 milliliters of chloroform, 820 milliliters of 90% ethanol.During making, a elder generation with alcohol-pickled 5-7 days, filters Fructus Mume, Radix Angelicae Dahuricae root, green Pericarpium Granati, Exocarpium Juglandis Immaturus, Radix Arnebiae (Radix Lithospermi), Cacumen Platycladi, Fructus Psoraleae (smashing to pieces), green Fructus Solani melongenae, Folium Ilicis Purpureae, Semen Cuscutae, forms traditional Chinese medicine liquid, and is stand-by; B dissolves propanoic acid chlorine third his rope with chloroform; C adds his rope solution of propanoic acid chlorine third and laurocapram in the traditional Chinese medicine liquid; D adds 220 milliliters of distilled water in the medicinal liquid; E bottling sterilization is stand-by.
Claims (3)
1. the leukodermic medicine for external use of treatment is characterized in that being made by following material: Fructus Mume 130-170 gram, Radix Angelicae Dahuricae root 50-70 gram, green Pericarpium Granati 50-70 gram, Exocarpium Juglandis Immaturus 50-70 gram, Radix Arnebiae (Radix Lithospermi) 30-50 gram, Cacumen Platycladi 80-100 gram, Fructus Psoraleae 110-130 gram, green Fructus Solani melongenae 260-340 gram, Folium Ilicis Purpureae 110-130 gram, Semen Cuscutae 80-100 gram, clobetasol propionate 0.1-0.3 gram, laurocapram 15-25 milliliter, chloroform 15-25 milliliter, 90% ethanol 750-850 milliliter; During making, carry out successively following operation: a Fructus Mume, Radix Angelicae Dahuricae root, green Pericarpium Granati, Exocarpium Juglandis Immaturus, Radix Arnebiae (Radix Lithospermi), Cacumen Platycladi, Fructus Psoraleae, green Fructus Solani melongenae, Folium Ilicis Purpureae, Semen Cuscutae with alcohol-pickled 5-7 days, filter, form traditional Chinese medicine liquid; B dissolves clobetasol propionate with chloroform; C adds clobetasol propionate lysate and laurocapram in the traditional Chinese medicine liquid; D adds distilled water diluting.
2. the leukodermic medicine for external use of a kind of treatment according to claim 1 is characterized in that the component of each material is: Fructus Mume 150 grams, Radix Angelicae Dahuricae root 60 grams, green Pericarpium Granati 60 grams, Exocarpium Juglandis Immaturus 60 grams, Radix Arnebiae (Radix Lithospermi) 40 grams, Cacumen Platycladi 90 grams, Fructus Psoraleae 120 grams, green Fructus Solani melongenae 300 grams, Folium Ilicis Purpureae 120 grams, Semen Cuscutae 90 grams, clobetasol propionate 0.2 gram, 20 milliliters of laurocapram, 20 milliliters of chloroform, 800 milliliters of 90% ethanol.
3. the leukodermic medicine for external use of a kind of treatment according to claim 1 is characterized in that: when adding distilled water diluting, the distilled water of adding is the 150-250 milliliter.
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| CN2009101727991A CN101703620B (en) | 2009-11-30 | 2009-11-30 | Externally applied medicament for treating vitiligo |
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| CN2009101727991A CN101703620B (en) | 2009-11-30 | 2009-11-30 | Externally applied medicament for treating vitiligo |
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| CN101703620B true CN101703620B (en) | 2011-07-20 |
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| CN101940695B (en) * | 2010-09-01 | 2014-04-23 | 黑龙江省亨发药业有限公司 | Chinese medicinal ointment for treating vitiligo and preparation method thereof |
| CN101983649A (en) * | 2010-11-19 | 2011-03-09 | 叶明� | Method for preparing traditional Chinese medicine tincture for curing leucoderma |
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