CN101684156A - Human TNF alpha monoclonal antibody, PEGylation nanoparticle and application thereof - Google Patents
Human TNF alpha monoclonal antibody, PEGylation nanoparticle and application thereof Download PDFInfo
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- CN101684156A CN101684156A CN200810200662A CN200810200662A CN101684156A CN 101684156 A CN101684156 A CN 101684156A CN 200810200662 A CN200810200662 A CN 200810200662A CN 200810200662 A CN200810200662 A CN 200810200662A CN 101684156 A CN101684156 A CN 101684156A
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Abstract
Description
?V2L | ??ATGGACATGCGGGTTCCAGCCCAGCTTCTCGGACTTCTGCTGTTGTGGCTGCGCGGAGCACGGTGCGAAATT ??GTGCTCACACAGTCACCAGACTTTCAGTCTGTCACCCCTAAGGAGAAAGTGACCATCACTTGCAGGGCCTCT ??CAGTTCGTCGGCTATAGTATCCACTGGTACCAGCAGAAACCCGATCAGTCCCCTAAACTGCTGATCAAGTAC ??GCCTCTGAATCAAGGTCAGGTGTCCCCAGTCGATTTTCTGGATCAGGATCTGGTACCGACTTCACCCTCACC ??ATCAATAGCTTGGAGGCCGAGGACGCTGCTACCTACTACTGCCAACAAAGCCACAGCTGGCACTTTACTTTT ??GGCCAGGGGACCAAGCTTGAGATCAAACGAACTGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGAT ??GAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTA ??CAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGAC ??AGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGC |
??GAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTTAGATTCAGAT ??CCGTTAACGGTTACCAACTACCTAGACTGGATTCGTGACACATGCGGCCGTGATATCTACGT ??ATGATCAGCCTCGAGGGCCCACGCGTAA ??(SEQ?ID?NO:1) | |
??V2H | ??ATGGAGTTCGGACTCAGTTGGCTGTTCCTGGTGGCCATCCTGAAGGGTGTGCAGTGTGAAGTCC ??AGCTGGTCGAGAGCGGTGGCGGGCTGGTGCAACCCGGTGGATCACTGCGGCTCAGCTGCGCTGC ??TAGTGGCTTTCCCTTCTCTAACCACTGGATGAATTGGGTCCGGCAGGCTCCAGGAAAGGGTCTG ??GAGTGGGTGGGTGAGATCAGGAGTAAGTCTATGAACTCCGCCACACACTATGCTGAAAGCGTGA ??AAGGGCGCTTCACAATCTCTAGAGACGATTCAAAGAACTCTCTGTACCTGCAGATGAACAGTCT ??GAAAACAGAGGACACCGCTGTGTATTACTGTGCTCGGAACTACTACGGTTCAACTTACGACCAC ??TGGGGCCAAGGTACACTGGTCACCGTCTCGAGTGCCTCCACCAAGGGCCCATCGGTCTTCCCCC ??TGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA ??CTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTC ??CCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCA ??GCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAA ??GAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTC ??CTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGA ??CCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTG ??GTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGC ??ACGTACCGGGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACA ??AGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGG ??GCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAG ??GTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCA ??ATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTT |
??CCTCTACAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC ??GTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAAT ??GA ??(SEQ?ID?NO:2) |
??2L | ??MDMRVPAQLLGLLLLWLRGARCEIVLTQSPDFQSVTPKEKVTITCRASQFVGYSIHWYQQKPDQSPKLLIK ??YASESRSGVPSRFSGSGSGTDFTLTINSLEAEDAATYYCQQSHSWHFTFGQGTKLEIKRTVAAPSVFIFPP ??SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKV ??YACEVTHQGLSSPVTKSFNRGEC ??(SEQ?ID?NO:3) |
??2H | ??MEFGLSWLFLVAILKGVQCEVQLVESGGGLVQPGGSLRLSCAASGFPFSNHWMNWVRQAPGKGLEWVGEIR ??SKSMNSATHYAESVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCARNYYGSTYDHWGQGTLVTVSSAST ??KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSS ??SLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCV ??VVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIE ??KTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSF ??FLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK ??(SEQ?ID?NO:4) |
Claims (10)
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CN101684156A true CN101684156A (en) | 2010-03-31 |
CN101684156B CN101684156B (en) | 2011-12-28 |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011085574A1 (en) * | 2010-01-15 | 2011-07-21 | 苏州工业园区晨健抗体组药物开发有限公司 | Complete human anti-tnf-alpha monoclonal antibodies, and manufacturing methods and uses thereof |
CN102260648A (en) * | 2010-05-27 | 2011-11-30 | 中国科学院生物物理研究所 | Recombinant mouse myeloma cells NS0-F10 and application thereof |
WO2012009977A1 (en) * | 2010-07-22 | 2012-01-26 | 苏州工业园区晨健抗体组药物开发有限公司 | FULLY HUMAN TNFα-FAB ANTIBODY AND PEGYLATED ANTIBODY THEREOF |
CN102443063A (en) * | 2010-09-30 | 2012-05-09 | 成都康弘生物科技有限公司 | Anti-TNFalpha humanized Fab, humanized antibody and its application |
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GB0013810D0 (en) * | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
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CN102443063A (en) * | 2010-09-30 | 2012-05-09 | 成都康弘生物科技有限公司 | Anti-TNFalpha humanized Fab, humanized antibody and its application |
CN102443063B (en) * | 2010-09-30 | 2013-10-23 | 成都康弘生物科技有限公司 | Anti-TNFalpha humanized Fab, humanized antibody and its application |
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