CN101663017A - Oral care products - Google Patents
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- CN101663017A CN101663017A CN200680022969A CN200680022969A CN101663017A CN 101663017 A CN101663017 A CN 101663017A CN 200680022969 A CN200680022969 A CN 200680022969A CN 200680022969 A CN200680022969 A CN 200680022969A CN 101663017 A CN101663017 A CN 101663017A
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Abstract
An oral care product comprising a strip and one or more oral care compositions. The oral care composition comprises an oral care active and when applied to the teeth the oral care product delivers oneor more oral care benefits.
Description
Invention field
The present invention relates to oral care active is delivered to system and method on the oral surfaces.
Background of invention
Though tooth whitening product is known in the art, these products are used by the people that those pursue the pure whiter beneficial effect attractive in appearance of tooth traditionally.Yet, exist the colony of different consumer of the pure whiter and/or more beneficial effects of expectation tooth, described beneficial effect to comprise to make tooth cleaner, make gums more healthy and reduce oral malodor.Therefore, need provide following oral care product, wherein except whitening teeth, but described product delivery of oral care beneficial effect also.In addition, these mouth care beneficial effects need be sent as the part of daily oral care regimen.
Summary of the invention
The method that one or more mouth care beneficial effects are delivered to oral surfaces comprises that the product that will comprise substrate and the oral care composition that comprises oral care active at least once was administered on a plurality of teeth and the contiguous soft tissue at least about five minutes every day at every turn, wherein described product is administered to every day on tooth and the contiguous soft tissue altogether greater than about six months time, and wherein at every turn use all use not used product.
The method that reduces tartar on the hard surface of oral cavity comprises:
To at least once be administered on a plurality of teeth and the contiguous soft tissue at least about five minutes every day by the product that substrate and one or more oral care compositions are formed at every turn, wherein at least a oral care composition comprises anti-calculus active matter, wherein described product is administered to every day on tooth and the contiguous soft tissue altogether greater than about one month time, and wherein at every turn use all use not used product.
Summary of drawings
Though this description is by particularly pointing out and clearly claimed claims of the present invention are drawn a conclusion; but it is believed that by the explanation and the contrast accompanying drawing of following preferred embodiment and can understand the present invention better; similar reference number is represented similar elements among the figure, wherein:
Fig. 1 is the perspective view of oral care product embodiment of the present invention;
Fig. 2 is the viewgraph of cross-section that the oral care product among Fig. 1 intercepts along its 2-2 line;
Fig. 3 is the perspective view of another embodiment of oral care product of the present invention;
Fig. 4 is the viewgraph of cross-section that the oral care product among Fig. 3 intercepts along its 3-3 line;
Fig. 5 is the perspective view of oral care product embodiment of the present invention;
Fig. 6 is the viewgraph of cross-section of the available embodiment of oral care product among Fig. 3, wherein illustrates a plurality of recesses or scrobicula;
Fig. 7 is the viewgraph of cross-section of another available embodiment of oral care product among Fig. 3, wherein described oral care composition is placed on the top of dental whitening compositions;
Fig. 8 is the viewgraph of cross-section of another embodiment of oral care product among Fig. 3, wherein shows the interval group compound between dental whitening compositions and oral care composition;
Fig. 9 is the viewgraph of cross-section of dental arch, its illustrate with the product among Fig. 3 be administered to a plurality of teeth to buccal surface with to lingual surface;
Figure 10 is the viewgraph of cross-section that dental arch intercepts along its 8-8 line among Fig. 9; It illustrates the oral care product among Fig. 3 is administered to adjacent a plurality of tooth to buccal surface with on some soft tissue of lingual surface;
Figure 11 is the perspective view of another embodiment of product among Fig. 3, and it illustrates optional release liners;
Figure 12 is the perspective view of another embodiment of product among Fig. 3, and it illustrates optional release liners;
Figure 13 is the perspective view of another embodiment of product among Fig. 3, and it illustrates optional release liners; With
Figure 14 is the perspective view of the another kind of oral care product of the present invention, has wherein shown the multiple mixed pattern of dental whitening compositions and oral care composition.
Detailed Description Of The Invention
Abbreviation used herein " cm " is meant centimetre.Abbreviation used herein " mm " is meant millimeter.Abbreviation used herein " mg " is meant milligram.Abbreviation used herein " g " is meant gram.
Term oral care composition used herein is meant any material that comprises one or more active substances with a certain amount of, wherein can send the oral cavity beneficial effect that the wearer pursues in use, and can not damage the oral surfaces that it is used.Described oral care composition can use one or more oral care active to handle one or more oral condition.The example of the handled oral condition of these oral care active include but not limited to tooth outward appearance and structure change, brighten, mottle bleaching, mottle removal, dental plaque removal, tartar removal, the prevention of dental caries and processing, gums is red and swollen and/or hemorrhage, mucosa injury, damage, ulcer, aphthous ulcer, chilblain ulcer and tooth abscess, oral malodor, tooth acid etching, gingivitis and/or periodontal.Oral condition is further described in the P that announced on January 10th, 2002; Among the WO 02/02096A2 of G.
Any material of the provided oral cavity holistic health change that can be used safely in the oral cavity is provided for phrase used herein " oral care active " or " active substance ".Specifically, the situation of the oral surfaces that described oral care substance contacted includes but not limited to teeth whitening, anti-calculus, dental caries and/or anti-microbial active matter or their any combination.
" safe and effective amount " used herein is meant in rational medical science/dentistry determination range enough high with remarkable improvement disease to be treated but enough hang down to avoid the activity substance content of serious adverse (have rational effect/danger than).The safe and effective amount of active substance can change according to concrete disease to be treated, the concrete form and the used specific medium thing of applying active substances of being treated patient's age and health, the seriousness of disease, the persistent period of treatment, the character of Synergistic treatment, used source.
Except as otherwise noted, all hereinafter used percentage ratios and ratio are all by the weight of whole oral care composition.
Except as otherwise noted, all measurements that the present invention relates to are all carried out under 25 ℃.
Except as otherwise noted, the percentage ratio of each composition of all that the present invention relates to, ratio and content is all based on the actual content of composition, and do not comprise as the commercially available prod solvent that can combine with these compositions, filler or other material.
Referring now to accompanying drawing, and more specifically with reference to Fig. 1 and 2, it has shown first embodiment of the present invention, and it represents with 10 that usually representative can provide the product of oral care composition to a plurality of teeth.This oral care composition can provide the single compositions of one or more oral cavity beneficial effects.Joint strip 12 can be coated with oral care composition 14.This oral care composition comprises active substance.In one embodiment, oral care active is a peroxide, and the oral cavity beneficial effect that is provided comprises teeth whitening and anti-calculus.Described oral care product 10 can comprise substrate, as initial flat basically joint strip 12, and can have fillet.Though joint strip 12 can be initial flat basically, can imagine with other form provides described joint strip.Described joint strip 12 can have as USPN 6,884, the shape and size described in 426.
In another embodiment, shown in 20 (Fig. 3 to 5), described product provides multiple mouth care beneficial effect via the multiple oral care composition that comprises one or more oral care active or a kind of oral care composition of comprising multiple oral care active, and wherein a kind of beneficial effect is a teeth whitening.In this embodiment, described product can provide the oral care composition with teeth whitening active substance to a plurality of teeth, and can provide be administered to a plurality of tooth adjacent soft tissue on the oral care composition with oral care active, described oral care active can provide non-brightening property mouth care beneficial effect, and described beneficial effect includes but not limited to anti-calculus, dental caries, antimicrobial etc.Described oral care product 20 can comprise substrate, as initial flat basically joint strip 22, preferably has fillet.Though joint strip 22 can be initial flat basically, can imagine with other form provides described joint strip.
In all embodiment of the present invention as herein described, the joint strip that is provided is an arch, or has the dens supporter shape of groove 23, described in USPN 2005/0089821,2004/0241616 and 2005/0089819, and shown in the example among Fig. 5.Described joint strip 22 also can have other shape and size, as USPN 6,884, described in 426.Described joint strip 22 can comprise scrobicula or pit, as USPN 6,136, and described in 297, and shown in example among Fig. 4.Alternatively, can imagine with a kind of form provides described product, and described form does not comprise substrate, and only comprises oral care composition such as dental whitening compositions, as USPN6, described in 419,906.
In one embodiment, as illustrated in fig. 1 and 2, oral care composition 14 is used or is coated on the joint strip 12.Provide described oral care composition 14 with the joint strip form, described joint strip is placed along at least a portion of joint strip 12.In one embodiment, described oral care composition extends along the longitudinal length of described joint strip basically.With certain shape and size described oral care composition is provided so that its only be administered to a plurality of teeth to buccal surface.Alternatively, provide described oral care composition with certain shape and size so that its during use with a plurality of teeth to buccal surface with contact to lingual surface and/or soft tissue.For example, described oral care composition is coated on the joint strip, make described joint strip be shaped with cover a plurality of facings to buccal surface, be enclosed within tooth cut end and cover a plurality of teeth to lingual surface.In another embodiment, a kind of two kinds of oral care compositions of teeth whitening beneficial effect that provide wherein are placed on (as shown in Fig. 3 to 5) on the joint strip 22 as joint strip.Can with a kind of oral care composition 25 near, contiguous or use along one or two periphery of joint strip 22 so that oral care composition contacts with at least a portion soft tissue of contiguous a plurality of teeth during use.During use, oral care composition can contact or also can not contact the sclerous tissues of a plurality of teeth.In this same embodiment, provide the oral care composition of teeth whitening beneficial effect to contact with the sclerous tissues of a plurality of teeth.
In one embodiment, the oral care composition that is provided can be used as be intended to contiguous a plurality of teeth to the contacted single joint strip of at least a portion soft tissue of buccal surface.In another embodiment, the oral care composition that is provided is two or more joint strips, wherein at least one joint strip is intended to contact at least a portion soft tissue of buccal surface with contiguous a plurality of teeth, and at least one joint strip is intended to and the contacting to lingual surface of a plurality of teeth.The oral care composition that is provided can be width 28 between the form of about 1mm between about 5mm.When two or more oral care composition joint strips are provided, imagine different joint strips and can mix different oral care active.For example, a joint strip can comprise first oral care active, and second joint strip then can comprise second oral care active different with first oral care active.Though multiple oral care composition is shown as successive joint strip in Fig. 3 to 5, can imagine provides as discontinuous joint strip, a plurality of joint strip or Else Rule or irregular shape them as point.Alternatively, a kind of oral care composition can be coated on substantially on the joint strip part, and second oral care composition is placed on first oral care composition, shown in the example among Fig. 7.In some embodiments, as shown in Fig. 3,4,5,6 and 7, multiple oral care composition is different.So-called difference in this article refers to the homogenization mixture to be compared, and has the compositions at clear and definite border or interface between the compositions usually.Border or a little mixing at the interface are to expect and consider in the different components notion.The difference that relates to active substance used herein is meant its chemical formula or forms different active substances.
In addition,, also can imagine though oral care composition has been described to place near the joint strip periphery, it can be positioned within other position of joint strip or on.For example, oral care composition can comprise and the mutually blended oral care active of polymeric material that forms joint strip.Maker can be administered to one or more oral care compositions on the joint strip 22 in advance, is packaged into then in pouch or other the suitable container to transport.
In one embodiment, every kind of two kinds of oral care compositions that all comprise one or more oral care active wherein are applied on the joint strip.In this embodiment, a kind of oral care composition comprises the teeth whitening active substance, and two kinds of oral care compositions are different.As shown in Figure 8, need between the oral care composition that comprises teeth whitening active substance 24 and second oral care composition 25, provide interval group compound 27.Can use the interval group compound to separate with second oral care composition 25 with the oral care composition that comprises teeth whitening active substance 24 at preparation, storage and/or operating period chien shih.Though can imagine other form, the interval group compound that is provided also can be the joint strip form.Described interval group compound can be made of gellant as herein described or binding agent.In one embodiment, described interval group compound does not comprise any oral care active.
With reference to Fig. 9 and 10, illustrate with product 20 be administered to a plurality of adjacent teeth 32 to buccal surface with to lingual surface, and contiguous a plurality of teeth are to buccal surface with on the part soft tissue 30 of lingual surface.Described soft tissue is meant adjacent teeth or between interdental any soft tissue, includes but not limited to, mastoid process, gum edge, gingival sulcus, interior gums, lingual surface and buccal surface to and comprise the gums structure of mucosa-gums junction and palate.Though shown in product 20 be applied on buccal surface and lingual surface and contiguous their the part soft tissue, also can imagine change product 20 size to be administered to than on the institute presentation surface surface still less.For example, the size that can change product 20 perhaps in another embodiment, is administered on buccal surface, its adjacent soft tissue and the part lingual surface, but is not administered on the soft tissue of contiguous lingual surface only to be administered on buccal surface and the adjacent soft tissue thereof.
With reference to Figure 11, product 20 can have optional release liner 37.Release liner 37 contiguous oral care compositions 24 and/or oral care composition 25 are placed.Can before being administered to product 20 on tooth and the soft tissue, remove optional release liner 37.Also can imagine, product 10 can have similarly optional release liner.In addition, (as shown in Figure 12 to 13) can be placed on two kinds of products on the release liner located adjacent one another 37 in one embodiment, makes a kind of shape of product be fit to go up denture 40, and makes a kind of shape of product be fit to mandibular dentition 42.In another embodiment, two kinds of products can be placed on the release liner 37 that has interval 44 between product, make a kind of shape of product be fit to go up denture 40, and make a kind of shape of product be fit to mandibular dentition 42.
Though it is unmixing different compositions with oral care composition that above-mentioned embodiment illustrates dental whitening compositions, but Figure 14 illustrates the perspective view of an embodiment, wherein dental whitening compositions and oral care composition are still different, but blended.As shown in Figure 14, the dental whitening compositions 24 that is provided is a plurality of points, mixes with the oral care composition 25 that provides as a plurality of points.The point that is provided can be multiple regular pattern, irregular pattern or their combination.Can use point is printed onto printing process on the joint strip, point is applied on the joint strip.Though demonstrate a little, can imagine provides multiple widely other shape (regular and irregular) and size.Some is applicable to that method of the present invention is solution printing, screen painting, intaglio printing, paste solder printing, ink jet printing, and the example is described in USPN2005/0128260,6,874, in 862 and 5,636,566.Described oral care composition can be used as solution or half heavy-gravity solution prints, and described solution becomes form becomes point or other structure.
Joint strip
Joint strip as herein described can be used as the protective barrier thing of oral care composition.It can prevent a large amount of losses of the oral care composition that causes because of for example wearer's antelabium, tongue and saliva and/or corrode.This makes oral care active act on the long time on their oral surfaces, from a few minutes to the several hrs.
Described joint strip can comprise any material, comprises one or more polymer, wax, foam, natural and synthetic woven material, non-woven material, paper tinsel, paper, rubber and their combination.The joint strip that is provided can be polymeric film.Described joint strip can be monolayer material or the laminated material that comprises more than one deck.For example, described joint strip can comprise the laminated material with two or more polymeric films, perhaps can comprise wax and non-woven material, for example polymerization scrim or the twine described in the USPN 2004/0005277.Described joint strip is water impervious basically.Some polymer that is suitable for preparing described joint strip includes but not limited to polyethylene, vinyl acetate ethyl ester, polyester, ethyl vinyl alcohol and their combination.The embodiment of polyester comprises and producing by E.I.Du Pont Company
With fluoroplastics as
Described joint strip can have less than about 1mm, or less than about 0.05mm, or the thickness between about 0.001 to about 0.03mm.
Described joint strip can have Any shape and size, its can cover a plurality of teeth to buccal surface and/or to lingual surface, and/or contiguous a plurality of teeth are to buccal surface and/or to the part soft tissue of lingual surface.In one embodiment, the length of described joint strip is extremely about 12cm of about 2cm, and is preferably about 4cm to about 9cm.The width of described joint strip also depends on oral surfaces area to be covered.In an example, the width of described joint strip is extremely about 4cm of about 0.5cm, and is preferably about 1cm to about 2cm.As shown in Figure 8, described joint strip is folding or otherwise be placed on the end of cutting of a plurality of teeth.Before using and/or between the operating period, the gross thickness of product 10 is less than about 2mm, or less than about 1mm, or less than about 0.5mm.
The deformeter that is fixed on the horizontal beam end by use is measured the flexural stiffness of described joint strip.Terminal horizontal being pressed on the sample of another of crossbeam forces the part ribbon to enter sample and puts perpendicular grooves on thereon the levelling bench.Be connected in microammeter on the deformeter with flexural force with the handy tinsel of gram calibration.The stiffness coefficient of sample can directly read from microammeter, and is expressed as the gram per centimeter sample bandwidth.In some embodiments, according to method of testing ASTM D2923-95, available from Thwing-Albert Instrument Co., Philadelphia, the #211-300 type Handle-O-Meter of PA goes up and measures, and described joint strip can have the flexural stiffness less than about 5g/cm.In other embodiments, described joint strip can have less than about 3g/cm, or less than about 2g/cm, or between the flexural stiffness of about 0.1g/cm to about 1g/cm.
Flexural stiffness is low can to make can the fit oral surfaces profile of wearer's mouth of described joint strip, and this is because almost there is not residual force can cause it to be returned to its shape before being about to be administered on the oral surfaces in the joint strip.The pliability of described joint strip can make it can contact the long time with soft tissue and not have stimulation, and described joint strip does not need to apply sizable pressure so that the surface of its applying tooth and/or soft tissue.
By by be applied on the joint strip, cover on the joint strip or with the bonding adhewsive action that blended one or more oral care compositions of joint strip, interval group compound or any other compositions or active substance/reagent place provide, described joint strip is fixed on the oral surfaces.Alternatively, by fixing joint strip at tooth to buccal surface and/or the mechanical pressure that distortion produced on lingual surface by joint strip.For example, during being administered on the tooth, when described joint strip stood permanent deformation, the stickiness that centers on tooth by pressure or joint strip fixed described joint strip.In some embodiments, described joint strip can be soluble or erodible during use.The case description of solubilized or erodible joint strip is in USPN 6,649 between the operating period, 147 and U.S. Patent application 2003/0228264 and 2004/0062724 in.Described joint strip can be less than about 1 hour, less than about 30 minutes, less than about 15 minutes or less than dissolving in 5 minutes or corrode.Joint strip dissolving or corrode after, oral care composition can remain in tooth to buccal surface and/or on lingual surface and/or soft tissue surfaces to continue to act on those surfaces.
In having some embodiments of multiple oral care composition, need make oral care composition subsequently with different speed dissolving or erosion.For example, after joint strip dissolving (or removing joint strip), the oral care composition rapidly dissolvable that comprises the teeth whitening active substance, and the oral care composition that comprises antibacterial substance dissolves more slowly, so that oral care active can continuingly act on soft tissue, or to the delivery of active substances of oral cavity long period.Joint strip removes, dissolves or the example of oral care composition that corrodes the back rapidly dissolvable is disclosed in USPN 6,669, in 930 and 5,098,303.Oral care composition is suitable for keeping maximum two days on oral cavity tissue.In another embodiment, oral care composition is suitable on oral cavity tissue keeping greater than about 30 hours, 1 hour, 2 hours, 4 hours, 6 hours, 8 hours, 10 hours, 12 hours, 14 hours, 16 hours, 18 hours or 20 hours and/or less than 24 hours, 20 hours, 18 hours, 16 hours, 14 hours, 12 hours, 10 hours, 8 hours, 6 hours or 4 hours and their any combination.The example that can adhere to the oral care composition of long period on oral cavity tissue is disclosed in USPN 2005/0100515 and 6,649, in 147.
Insoluble or not during erodable when described joint strip, described joint strip and one or more oral care compositions can be removed on dental surface and soft tissue fully, residual after removal, to have little or no remaining oral care composition.Alternatively, removing of described joint strip can be removed a kind of oral care composition such as teeth whitening oral care composition fully, and on oral cavity tissue, keep second oral care composition, so that the oral care active in second oral care composition can continue to act on for a long time described tissue.Under latter event, with first oral care composition adhesion affinity of joint strip is compared, second oral care composition can have littler adhesion affinity to joint strip, still can keep second oral care composition to adhere at first oral care composition when joint strip is also removed thereupon.With a part of joint strip that second oral care composition contacts on, described joint strip can have coating release coat (as special teflon, siloxanes, fluoropolymer etc.) thereon, to help when tooth removes joint strip or to realize release between the joint strip and second oral care composition.
Bar for 1.5cm is wide, removes the required peeling force of joint strip between about 1 gram restrains to about 50 (whole about 17g/cm that is required to be) from dental surface and soft tissue.In another embodiment, peeling force can between about 10 the gram to about 40 the gram between, or between about 20 the gram to about 30 the gram between.
With reference to Figure 11, described joint strip 12 can also be bored a hole.Can be near oral care composition 15 or below perforation is provided, for example, be suitable for the easier dissolving of oral care active or otherwise be diffused into position in the oral cavity.The perforation that is provided can be rule or irregular pattern.
Oral care composition
The oral care composition of the present invention that can use Several Methods will comprise the oral care active of safe and effective amount locally applies in the oral mucosas tissue, on the gingival tissues of oral cavity, on the dental surface and/or in their any combination with treatment or prevent above-mentioned oral condition.The amount that is administered to the oral care substance on joint strip or the oral surfaces depends on size and capacity, the concentration of active substance and the desired beneficial effect of paster.Usually, use the oral substance that restrains less than about 1.In one embodiment, use the oral care substance of about 0.05 gram to about 0.5 gram.In another embodiment, use about 0.1 oral care substance to about 0.4 gram.Oral care composition comprises oral care active from one or more beneficial effects to soft tissue that can send, or in some cases, comprises oral care active from one or more beneficial effects to the tooth hard tissue that can send.Described oral care active can be to it has been generally acknowledged that any material that can be used safely in the oral cavity, and described material can provide the change of oral cavity holistic health, and the change of the oral surfaces situation that oral care active contacts can be provided specifically.In one embodiment, the content of oral care active in oral care composition of the present invention is about 0.01% to about 40%.In another embodiment, the content of oral care active in oral care composition is about 0.1% to about 20%.In another embodiment, the content of oral care active in oral care composition is about 0.5% to about 10%, and in another embodiment, the content of oral care active in oral care composition is about 1% to about 7%, and in another embodiment, the content of oral care active in oral care composition is about 0.5% to about 5%.Beneficial effect can comprise teeth whitening and/or bleaching beneficial effect, antimicrobial or sterilization beneficial effect, anti-calculus beneficial effect, dental caries beneficial effect, antiallergic beneficial effect, prevent stench beneficial effect etc.Described oral care composition can comprise one or more oral care active.In one embodiment of the invention, described oral care composition comprises a kind of oral care active of sending multiple mouth care beneficial effect.In another embodiment of the invention, described oral care composition comprises multiple oral care active, and wherein every kind of oral care active is sent different mouth care beneficial effects.In another embodiment, described oral care composition comprises about 0.5% to about 5% non-whitening type oral care active and about 1% to about 30% the oral care active that brightens.In another embodiment, described oral care composition comprises about 0.5% to about 3% non-whitening type oral care active and about 1% to about 10% the oral care active that brightens.In one embodiment, described oral care composition comprises by the pyrophosphate of described oral care composition gross weight about 1% to about 3% with by the peroxide of described oral care composition gross weight about 1% to about 10%.
Also can imagine, single oral care product can comprise multiple oral care composition, and wherein every kind of oral care composition all comprises one or more oral care active.Some oral care active that is applicable to oral care composition more completely is discussed in hereinafter.
Described oral care composition can comprise one or more gellant, and it can be used as binding agent so that described oral care composition is sticked on a plurality of teeth.The concentration of gellant by the weight of described oral care composition greater than about 2%, 4%, 6%, 8%, 10%, 15%, 20%, 30%, 40%, 50%, 60%, or less than about 80%, 70%, 60%, 50%, 40%, 30% or 20%.
Be applicable to that gellant of the present invention, adhesive agent and/or oral care composition are described in USPN6, in 649,147,6,780,401,2004/0102554,2005/0089819,2003/0152528,6,419,906 and 2005/0100515.Some gellant or adhesive agent can comprise siloxanes, poly(ethylene oxide), polyvinyl alcohol, poly-alkyl vinyl ether-maleic acid (PVM/MA copolymer) is (as Gantrez AN 119, AN 139 and S-97), polyvinyl alcohol, polyacrylic acid, poloxamer 407 (Pluronic), polyvinylpyrrolidone-vinyl acetate copolymer (PVP/VA copolymer) (as Luviskol VA and Plasdone SPVP/VA), polyvinylpyrrolidone (PVP is as K-15 to K-120), polyquaternary ammonium salt-11 (Gafquat 755N), polyquaternary ammonium salt-39 (Merquat plus 3330), carbomer or carbopol (Carbopol), hydroxypropyl emthylcellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, gelatin and alginate (as sodium alginate), natural gum is (as karaya, xanthan gum, guar gum, Radix Acaciae senegalis, Tragacanth), and their mixture.
Wetting agent or plasticizer be can comprise in the described oral care composition, glycerol, sorbitol, Polyethylene Glycol, propylene glycol and other edible polyhydric alcohol comprised.The content of wetting agent by the weight of described oral care composition between about 10% to about 95%, or between about 50% to about 80%.Oral care composition also can comprise flavoring agent, sweeting agent, opacifier and stain.
Can comprise water in the described oral care composition.The concentration of water by the weight of described oral care composition greater than about 0%, 2%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40% or 45%, and/or less than about 80%, 70%, 60%, 50% or 40% and their any combinations.
1. teeth whitening active substance
In general, will be administered on the joint strip less than the oral care composition that comprises the teeth whitening active substance of about 1 gram.In one embodiment, use between about 0.05 gram restrains to about 0.5, or restrain to the oral care composition that comprises the teeth whitening active substance between about 0.4 gram between about 0.1.The amount of oral care composition that comprises the teeth whitening active substance in every square centimeter of material is less than about 0.2g/cm
2, preferred about 0.005 to about 0.1g/cm
2, and 0.01g/cm more preferably from about
2To about 0.04g/cm
2
The oral care composition that comprises the teeth whitening active substance can be provided in a variety of forms, and as solid, semisolid or liquid, described liquid comprises heavy-gravity liquid, paste, gel or solution.The oral care composition that comprises the teeth whitening active substance is preferably gel form.The oral care composition that comprises the teeth whitening active substance can have between about 0.2Pa.s (200cps) to about 5 under low shear rate (less than about 1/ second), and 000Pa.s (5,000, the 000cps) viscosity between.In one embodiment, (100,000cps) and about 1,500Pa.s (1 between about 100Pa.s for described viscosity, 500,000cps) between, and in another embodiment, described viscosity is between about 400Pa.s (400,000cps) and about 1,000Pa.s (1,000,000cps) between.
Polymerization twine or scrim can be incorporated in the oral care composition that comprises the teeth whitening active substance.
Be applicable to that teeth whitening or bleaching activity material in the oral care composition comprise peroxide, metal chlorite, perborate, percarbonate, peroxy acid and their combination.Suitable peroxide comprises hydrogen peroxide, calper calcium peroxide, urea peroxide and their mixture.The metal chlorite that is fit to comprises calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite and potassium chlorite.Additional whitening actives can be hypochlorite and chlorine dioxide.Described oral care composition can comprise by the weight of described oral care composition greater than about 2%, 4%, 6%, 8%, 10%, 15%, 20%, and/or less than about 40%, 25%, 20%, 18%, 16%, 14%, 12% or 10% teeth whitening active substance.
Can imagine, any one in the daily use embodiment of the present invention and/or their combination are as the part of oral care regimen.Use these oral care compositions of the present invention can allow user can obtain and keep the mouth care beneficial effect of multiple expectation, include but not limited to obtain the tooth of pure white no tartar as the part of daily oral care regimen.Yet if described oral care composition comprises peroxide, and contact oral cavity every day comprises the compositions of peroxide, wishes to use oral surfaces is had high resistance and can at utmost reduce the oral care composition that hemodia takes place.The example that can tolerate oral soft tissue and can at utmost reduce the oral care composition that hemodia takes place comprise peroxide concentrations by the gross weight of described dental whitening compositions less than about 7.5% and peroxide density less than about 1.3mg/cm
2A kind of oral care composition.In one embodiment, described dental whitening compositions has by the weight of described dental whitening compositions greater than about 0.01% and less than about 7.5% peroxide concentrations with less than about 1.3mg/cm
2Peroxide density.In another embodiment, described dental whitening compositions has by the weight of described dental whitening compositions greater than about 6.5% and less than about 7.5% peroxide concentrations with less than about 1.3mg/cm
2Peroxide density.In another embodiment, described dental whitening compositions has by the weight of described dental whitening compositions greater than about 6.0% and less than about 6.5% peroxide concentrations with less than about 1.3mg/cm
2Peroxide density, and in another embodiment, described dental whitening compositions has by the weight of described dental whitening compositions less than about 6.0% peroxide concentrations with less than about 1.3mg/cm
2Peroxide density.
Peroxide density is amount (mg) or the peroxide dosage and the thin layer surface area (cm that is administered on the contiguous soft tissue in dental surface and oral cavity of peroxide active
2) ratio.Peroxide density and calculating thereof are discussed in United States Patent (USP) 6,949, in 240.In most of the cases, if whole joint strip is administered in the oral cavity, and if whole joint strip be coated with the dental whitening compositions thin layer, then the thin layer surface area is approximately the joint strip surface area.For example, if described joint strip is a rectangle, and long 6.5cm, wide 1.54cm, and also the dental whitening compositions thin layer is coated on the whole joint strip face, and then total surface area is 10cm
2If described dental whitening compositions comprises 6.5% hydrogen peroxide, and described joint strip comprises the described dental whitening compositions of 0.2g, and then hydrogen peroxide dosage is 13mg.Corresponding peroxide density is 1.3mg/cm
2
2. anti-calculus active matter
The anti-calculus active matter that becomes known in the dental care products comprises phosphate.Phosphate comprises pyrophosphate, Quadrafos, polyphosphonate and their mixture.What know the most in dental care products is pyrophosphate.The pyrophosphate ion of sending to tooth is derived from pyrophosphate.The pyrophosphate that can be used in the present composition comprises two alkali metal pyrophosphates, four alkali metal pyrophosphates and their mixture.The not hydration and the hydrated form of Sodium Acid Pyrophosphate (Na2H2P2O7), tetrasodium pyrophosphate (Na4P2O7) and tetrapotassium pyrophosphate (K4P2O7) are preferred substances.Though can use above-mentioned any pyrophosphate, preferred tetrasodium pyrophosphate salt.In one embodiment, described oral care composition comprises the pyrophosphate by the weight of described oral care composition about 0.5% to about 5%.In another embodiment, described oral care composition comprises the pyrophosphate by the weight of described oral care composition about 0.5% to about 3%.
Pyrophosphate is described in greater detail in Kirk ﹠amp; In " Encyclopedia ofChemical Technology " third edition the 17th volume (Wiley-IntersciencePublishers, 1982) of Othmer, described document is incorporated this paper in full with way of reference, comprises Kirk﹠amp; All lists of references of being introduced among the Othmer.Additional anti-dental calculus active substance comprises authorized Parran on May 20th, 1986; Disclosed pyrophosphate or Quadrafos in the United States Patent (USP) 4,590,066 of Sakkab; Polyacrylate and other polycarboxylate were authorized the United States Patent (USP) of Chang on the 8th and on April 28th, 4,304,766 and 1987 were authorized Benedict as 3,429,963 and 1981 years Decembers of the United States Patent (USP) of authorizing Shedlovsky on February 25th, 1969; In the United States Patent (USP) 4,661,341 of Sunberg disclosed those; Polyepoxysuccinic acid salt is as authorizing Benedict, Bush on July 11st, 1989; In the United States Patent (USP) 4,846,650 of Sunberg disclosed those; It as the date disclosed ethylenediaminetetraacetic acid in the British patent 490,384 in February 15 nineteen thirty-seven; As authorizing Widder on July 18th, 1972; Disclosed nitrilotriacetic acid and related compound in the United States Patent (USP) 3,678,154 of Briner; On October 26th, 3,737,533,1976 authorized Ploger, Schmidt-Dunker as the United States Patent (USP) of authorizing Francis on June 5th, 1973; The United States Patent (USP) of Gloxhuber on October 31st, 3,988,443,1989 was authorized Degenhardt; Disclosed polyphosphonate in the United States Patent (USP) 4,877,603 of Kozikowski, all these patents are all incorporated this paper into way of reference.Anti-dental calculus phosphate comprises potassium pyrophosphate and tetrasodium pyrophosphate; Sodium tripolyphosphate; Diphosphate, as ethane-1-hydroxyl-1,1-diphosphate, 1-azepan-1,1-diphosphate and straight chained alkyl diphosphate; The straight-chain carboxylic acid; And Zinc sodium citrate..
Be used to replace pyrophosphate or comprise known substance with active substance that pyrophosphate is used in combination, as synthetic anionic polymer, the copolymer (as Gantrez) that comprises polyacrylate and maleic anhydride or maleic acid and methyl vinyl ether, as authorize people's such as Gaffar United States Patent (USP) 4,627, described in 977, its disclosure is incorporated this paper in full with way of reference; And for example poly-aminopropanesulfonic acid (AMPS), three hydration zinc citrates, Quadrafos (as tripolyphosphate, hexametaphosphate), diphosphate (as EHDP, AHP), polypeptide (as poly-aspartate and polyglutamic acid) and their mixture.
Other anti-calculus active matter comprises sodium hexameta phosphate.
3. dental caries active substance
As everyone knows, fluoride sources can be used as the dental caries active substance and is used for oral care composition.Fluorion is contained in the numerous oral care composition that is used for this purposes, especially toothpaste.The patent that discloses above-mentioned toothpaste comprises the United States Patent (USP) 3,538,230 of authorizing people such as Pader on November 3rd, 1970; JIUYUE in 1972 were authorized the United States Patent (USP) 3,689,637 of Pader on the 5th; Authorized people's such as Colodney United States Patent (USP) 3,711,604 on January 16th, 1973; Authorized the United States Patent (USP) 3,911,104 of Harrison on October 7th, 1975; Authorized people's such as Roberts United States Patent (USP) 3,935,306 on January 27th, 1976; And on August 9th, 1977 authorize the United States Patent (USP) 4,040,858 of Wason.
Using fluorion to enamel can be used for taking care of one's teeth in case decay tooth.The material that can use multiple generation fluorion is as the soluble fluoride source in the present composition.The example that produces the suitable material of fluorion is found in the United States Patent (USP) 3,535,421 of authorizing people such as Briner on October 20th, 1970; Authorize with on July 18th, 1972 in people's such as Widder the United States Patent (USP) 3,678,154, these two patents are all incorporated this paper into way of reference.The fluorine ion source that preferably can be used for this paper comprises stannous fluoride, mono-fluor phosphate, sodium fluoride, potassium fluoride and ammonium fluoride.Especially preferred fluorinated sodium.When use is used for the joint strip in oral cavity, with aqueous solution that dental surface contacts in, compositions of the present invention preferably can provide about 50ppm to 10,000ppm, more preferably from about 100 to 3000ppm fluorion.
Other dental caries active substance comprises xylitol.
4. anti-microbial active matter
Antimicrobial property material while still alive also can be included in the oral care composition.Above-mentioned active substance includes but not limited to 5-chloro-2-(2, the 4-dichlorophenoxy)-phenol, it is commonly called triclosan, and be described in " Merck Index " the 11st edition (1989) the 1529th pages of (entry number 9573), United States Patent (USP)s 3, the BeechamGroup that on January 7th, 506,720 and 1988 announced, the european patent application 0 of PLC, in 251,591; Phthalic acid and salt thereof include but not limited to the United States Patent (USP) 4,994 on February 19th, 1991, in 262 disclosed those, the adjacent carboxyl that replaces is crossed a benzoic acid and salt and ester, as the United States Patent (USP) 4,990 in 5 days February in 1991 of all authorizing Sampathkumar, 329, the United States Patent (USP) 5 on May 5th, 1992,29, United States Patent (USP) of 110,583 and 1987 on Decembers 4,716, disclosed in 035, preferred adjacent carboxyl is crossed a magnesium benzoate; Chlohexidine (Merck Index, numbering 2090), Win-21904 (Merck Index, numbering 222); Hexatidine (Merck Index, numbering 4624); Sanguinarine (Merck Index, numbering 8320); Alkyl benzyl dimethyl ammonium chloride (Merck Index, numbering 1066); Salicylamide (Merck Index, numbering 8299); Brominated phenododecinium bromide (Merck Index, numbering 3411); Cetylpyridinium chloride (CPC) (Merck Index, numbering 2024); TPC (TPC); Chlorination N-myristyl-4-ethylpyridine (TDEPC); Octenidine; Delmopinol, Octapinol and other sub-base derivatives of piperidine; Niacin preparation; Zinc/stannous ion active substance; Antibiotic, as augmentin, amoxicillin, tetracycline, doxycycline, minocycline and metronidazole, and above-mentioned analog and salt; Quintessence oil comprises thymol, geraniol, carvacrol, citral, chamenol, cineole, catechol (especially 4-pi-allyl catechol); Metal or metal ion (as silver, copper, zinc etc.) and their mixture; Methyl salicylate; The mixture of chlorite and chlorous acid slaine and above-mentioned all substances.
5. antiinflammatory and antiallergic activity material
The anti-inflammatory activity material also can be included in the oral care composition.Above-mentioned active substance includes but not limited to on-steroidal anti-inflammatory activity material or NSAID, as ketorolac, flurbiprofen, ibuprofen, naproxen, indometacin, aspirin, ketoprofen, piroxicam and meclofenamic acid.The application of NSAID such as ketorolac is subjected to the United States Patent (USP) 5 of announcement on May 6th, 1997; 626; the protection of 838 claims; described document is incorporated herein with way of reference, wherein discloses the method that prevents and/or treats constitutional and recurrent squamous cell carcinoma in oral cavity or the oropharynx by the NSAID to oral cavity or oropharynx local application effective dose.
The antiallergic activity material can comprise potassium nitrate, Oleum Caryophylli (acetaminol) and other herbaceous plant or flavored active material/reagent.
6. nutrient substance
Nutrient substance can improve oral conditions and can be included in the oral care composition.Nutrient comprises mineral, vitamin, oral cavity nutritional supplement, enteral nutrition enriching substance and their mixture.
The mineral that can be included in the present composition comprises calcium, phosphorus, fluoride, zinc, manganese, potassium and composition thereof.These mineral be disclosed in " Drug Facts andComparisons " (information service of loose-leaf pharmaceuticals) (Wolters Kluer Company, St.Louis, Mo.,
) in the 10th to 17 page, described document is incorporated herein with way of reference.
Vitamin can comprise or use separately with mineral.Vitamin comprises vitamin C and D, thiamine, riboflavin, calcium pantothenate, nicotinic acid, folic acid, nicotiamide, pyridoxin, cobalamin, Para-Aminobenzoic, bioflavonoids and their mixture.These vitamin be disclosed in " Drug Facts and Comparisons " (information service of loose-leaf pharmaceuticals) (WoltersKluer Company, St.Louis, Mo.,
) in the 3rd to 10 page, described document is incorporated herein with way of reference.
The oral cavity nutritional supplement comprises aminoacid, lipotropic, fish oil and their mixture, as " Drug Facts and Comparisons " (information service of loose-leaf pharmaceuticals) (Wolters Kluer Company, St.Louis, Mo.,
) disclosed in the 54th to 54e; Described document is incorporated herein with way of reference.Aminoacid includes but not limited to L-tryptophan, L-lysine, methionine, threonine, levocarnitine or L-carnitine and their mixture.Lipotropic includes but not limited to choline, inositol, betanin, linoleic acid, linolenic acid and their mixture.Fish oil contains a large amount of ω-3 (N-3) polyunsaturated fatty acid, eicosapentaenoic acid and docosahexenoic acid.
The enteral nutrition enriching substance includes but not limited to protein product, glucose polymer, Semen Maydis oil, safflower oil, medium chain triglyceride, as " Drug Facts and Comparisons " (Wolters Kluer Company, St.Louis, Mo.,
) disclosed in the 55th to 57, described document is incorporated this paper into way of reference.
7. enzyme
Can comprise the combination of independent enzyme or some compatible enzymes in the described oral care composition.Enzyme is the biocatalyzer of chemical reaction in the life system.The substrate of enzyme and its effect is combined to form the enzyme-substrate complex intermediate.This complex is converted into the enzyme of product and free state then, and enzyme continues the function of its concrete enzyme of performance.
When being used for cleaning oral cavity, enzyme can provide some beneficial effects.Protease decomposes the sialoprotein matter that is absorbed in dental surface and forms thin film (ground floor of gained dental plaque).Protease is together with lipase, and protein and lipoid by cracking formation bacterial cell wall and after birth structural constituent destroy antibacterial.Glucanase destroy by forms substrate with the adhesion antibacterial that antibacterial was produced was organic framework structured.Protease and amylase prevent mineralising by decomposing and the bonded extra-cellular carbohydrate-protein complex of calcium, can prevent that not only dental plaque from forming, and can prevent the dental calculus growth.
Be applicable to that enzyme of the present invention comprises any commercially available protease, glucan hydrolase, interior glycosidase, amylase, mutant enzyme, lipase and mucase or their compatible mixture.Preferably protease, glucanase, interior glycosidase and mutant enzyme most preferably are the mixture of papain, interior glycosidase or glucanase and mutant enzyme.Be applicable to that other enzyme of the present invention is disclosed in the United States Patent (USP) 5,000,939 of authorizing people such as Dring on March 19th, 1991; Authorized the United States Patent (USP) 4,992,420 of Neeser on February 12nd, 1991; Authorize the United States Patent (USP) 4,355,022 of Rabussay October 19 nineteen eighty-two; Authorized the United States Patent (USP) 4,154,815 of Pader on May 15th, 1979; Authorized the United States Patent (USP) 4,058,595 of Colodney on November 15th, 1977; Authorized people's such as Virda United States Patent (USP) 3,991,177 on November 9th, 1976; Authorize in the United States Patent (USP) 3,696,191 of Weeks with on October 3rd, 1972, all documents are all incorporated this paper into way of reference.
8. oral cavity and throat product
Other material that can be used among the present invention comprises common known oral cavity and throat product.The said goods be disclosed in " Drug Facts and Comparisons " (information service of loose-leaf pharmaceuticals) (Wolters Kluer Company, St.Louis, Mo.,
) among the 520b to 527, described document is incorporated this paper into way of reference.These products include but not limited to Fungicidal active substance, antibiotic activity material and analgesic activity material.
9. antioxidant
Antioxidant is considered to can be used in the compositions usually, as among the present invention those.Antioxidant is disclosed in the works, as " the The Handbook ofAntioxidants " of Cadenas and Packer
Marcel Dekker, Inc.), described document is incorporated herein with way of reference.The antioxidant that can be included in oral care composition of the present invention or the material includes but not limited to: vitamin E, ascorbic acid, uric acid, carotenoid, vitamin A, flavone compound and polyphenol, herbaceous plant antioxidant, melatonin, amino indole, thioctic acid and their mixture.
10.H-2 antagonist
Histamine-2 (H-2 or H2) receptor agonist compounds (H-2 antagonist) can be used in the oral care composition of the present invention.Selectivity H-2 antagonist used herein is to intercept the H-2 receptor, but does not have meaningful active chemical compound aspect obstruct histamine-1 (H-1 or the H2) receptor.Selectivity H-2 antagonist stimulates multiple organ such as intestinal and bronchial smooth muscle contraction; This effect can suppress by the concentration that reduces pyrilamine (a kind of typical hydryllin medicine).Relate to these pharmacology's receptors and be defined as H-1 receptor (Ash, A.S.F. ﹠amp the histamine response of neoantergan sensitivity; Schild H.O., " Brit.J.PharmacolChemother. " the 27th volume (1966), the 427th page, described document is incorporated this paper into way of reference).Histamine also can stimulate secretion (Loew, the E.R. ﹠amp of gastric acid; O.Chickering, " Proc.Soc.Exp.Biol.Med. ", the 48th volume (1941), the 65th page, described document is incorporated herein with way of reference), increase heart rate (Trendelenburg, U., " J.Pharmacol. " the 130th volume (1960), the 450th page, described document is incorporated this paper into way of reference), and the contraction (Dews, the P.B. ﹠amp that suppress rat uterus; J.D.P.Graham, " Brit.J.Pharmacol.Chemother. ", the 1st volume (1946), the 278th page, described document is incorporated this paper into way of reference), these effects can't be offset by pyrilamine and related drugs.The H-2 antagonist that can be used in oral care composition or the oral care substance is that the related receptor of the non-H-1 of pyrilamine insensitivity (H-2) type histamine response is blocked, but the related receptor of pyrilamine sensitivity histamine response is not blocked those.
Selectivity H-2 antagonist is at those chemical compounds that are defined as the H-2 antagonist at the performance in the screening test before H-2 antagonist action classical clinical by them.Selectivity H-2 antagonist is confirmed as such chemical compound, it depends in the screening model of H-2 function of receptors specially at those, for being the effect of media with the histamine, show and can be used as competitiveness or noncompetitive inhibitor, but depend in the screening model of H-1 function of receptors at those, lack significant histamine antagonist activity.Specifically, according to Black, J.W., W.A.M.Duncan, C.J.Dur ant, C.R.Ganellin ﹠amp; " Definition andAntagonism of Histamine H@-Receptors " (Nature of E.M.Parsons, the 236th volume (on April 21st, 1972) the 385th to 390 page (Black), described document is incorporated this paper into way of reference) described in, if it is described according to Black, test evaluation by in vitro measuring with the spontaneous pollex of guinea pig right atrium in vitro to measure with rat tolerance secretion, then this comprises the chemical compound that is classified as the H-2 antagonist, if it is but described according to Black, shrink with guinea pig ileum and in vitro to measure or the rat abdominal muscle shrinks in vitro to measure and evaluates, then compare with the H-2 antagonist activities, described compound exhibits lacks significant H-1 antagonist activities.Under rational dosage, selectivity H-2 antagonist does not preferably show significant H-1 activity in above-mentioned H-1 evaluation.Typical reasonable dosage is in above-mentioned H-2 evaluation, realizes suppressing 90% histamine, the lowest dose level when preferably suppressing 99% histamine.
Selectivity H-2 antagonist comprises the chemical compound that meets above-mentioned standard, and it is disclosed in respectively and authorizes people such as Singer and transfer Procter ﹠amp 3/15/94 and 11/15/94; The United States Patent (USP) 5 of Gamble, 294,433 and 5,364, in 616, described document is incorporated herein with way of reference, and wherein selectivity H-2 antagonist is selected from the group of being made up of following material: cimetidine, lupitidine, ranitidine, ICIA-5165, tiotidine, ORF-17578, Lu's skin is for fourth, the winter Buddhist nun is for fourth, famotidine, roxatidine, the piperazine virtue is for fourth, lamtidine, BL-6548, BMY-25271, zaltidine, nizatidine, mifentidine, BMY-52368, SKF-94482, BL-6341A, ICI-162846, ramixotidine, Wy-45727, SR-58042, BMY-25405, loxtidine, DA-4634, bisfentidine, sufotidine, ebrotidine, HE-30-256, D-16637, FRG-8813, FRG-8701, impromidine, L-643728 and HB-408.4. especially preferred cimetidine (SKF-92334), N-cyano group-N '-methyl-N " (2-(((5-methyl isophthalic acid H-imidazol-4 yl) methyl) sulfo-) ethyl) guanidine:
Cimetidine also is disclosed among " the Desk Reference " the 46th edition (1992) the 2228th pages of " Merck Index " the 11st edition (1989) the 354th pages (entry number 2279) and Physicians.Preferred relevant H-2 antagonist comprises burimamide and metiamide.
Described oral care composition (with the interval group compound) also can comprise gellant and other and openly be used for those same or analogous compositions of teeth whitening oral care composition.In one embodiment, the teeth whitening oral care composition comprises different gellant or adhesive agent or their combination with oral care composition, to give different adhesion characteristics to teeth whitening oral care composition and oral care composition.Though oral care active be described to teeth whitening oral care composition oral care composition placed apart on shaped portion, mix with dental whitening compositions but also can imagine oral care active, and/or dental whitening compositions also can be sent the oral cavity beneficial effect except that teeth whitening or bleaching.For example, oral care active can be mixed with the material that forms twine or scrim part in dental whitening compositions, and perhaps oral care active can be mixed with joint strip.
Though above-mentioned oral care composition can be made of ingredients listed above, but be to be understood that, oral care composition can comprise or not comprise these compositions of determining after preparation, this should be owing to contingent variation or reaction during the preparation of oral care composition.
Using method
Can be in a number of ways, with the present composition of safe and effective amount locally apply in the oral mucosas tissue, on the gingival tissues of oral cavity and/or on the dental surface with treatment or prevent above-mentioned disease.
Product 10 and/or 20 can be used on tooth and/or soft tissue about 1 minute to about 8 hours.In some embodiments, hope is according to a scheme, wherein described product is used greater than about 1 minute, 2 minutes, 3 minutes, 4 minutes, 5 minutes, 6 minutes, 7 minutes, 8 minutes, 9 minutes, 10 minutes, 15 minutes, 20 minutes, 30 minutes, 40 minutes, 50 minutes, 60 minutes, 90 minutes, 120 minutes, 150 minutes, 180 minutes, 210 minutes, 240 minutes, 270 minutes, 300 minutes, 330 minutes, 360 minutes, 390 minutes, 420 minutes, 450 minutes, 480 minutes, and/or less than 480 minutes, 450 minutes, 420 minutes, 390 minutes, 360 minutes, 330 minutes, 300 minutes, 270 minutes, 240 minutes, 210 minutes, 180 minutes, 150 minutes, 120 minutes, 90 minutes, 60 minutes, 50 minutes, 40 minutes, 30 minutes, 20 minutes, 15 minutes, 10 minutes, 9 minutes, 8 minutes, 7 minutes, 6 minutes, 5 minutes, 4 minutes, 3 or 2 minutes, and their any combination, the concentration of wherein said oral care active by the weight of described oral care composition between about 1% to about 50%.Once a day, such scheme is advantageously used greater than about one month, two months, four months, six months, 12 months, 18 months, 2 years, 5 years, 8 years, 10 years, and/or less than about 15 years, 10 years, 8 years, 5 years, 2 years, 18 months, 12 months, six months, four months, two months, one month and their any combination.In another embodiment, once a day, such scheme is advantageously used greater than about one month, and less than about 5 years.The cover box that is provided can comprise the supply of the product 10 that is used for denture and mandibular dentition and/or 20 1 months, two months, three months, four months, five months, six months or 12 months.For example product 10 and/or 20 can be packaged in the pouch, and a plurality of packaged products 10 and/or 20 are provided in storage container or outer package or carton then, as USPN D496, shown in the example in 495.Two joint strips that comprise one or more oral care compositions can be included in unitary package such as the pouch, and a joint strip is used for denture, and one is used for mandibular dentition.Also can adopt such scheme,, wherein wear described product in shower or during taking a shower to be used between morning or the shower in night.
In another embodiment, described product is used greater than about 1 minute, 2 minutes, 3 minutes, 4 minutes, 5 minutes, 10 minutes, 15 minutes, 20 minutes, 25 minutes, 30 minutes or 35 minutes and/or less than about 60,55,50,45 or 40 minutes and their any combination, wherein in some embodiments, the concentration of oral care active by the weight of described oral care composition greater than 5%, and/or the concentration of oral care active by the weight of described oral care composition less than about 10%.Product 10 and/or 20 can be packaged in pouch or other container.The packaged product of enough numbers can be provided as the cover box.Described cover box can comprise directions for use, describes the operational version of packaged product.The good product number of cover box intermediate package can differ bigger, but can be between about 6 to about 200 according to scheme.In one embodiment, described cover box comprises greater than about 10,20,30,40, and less than about 200,100,50,45,40 packaged products, and/or their any combination, each packaged product comprises two joint strips that contain oral care composition, make one size applying go up denture, and make one size applying mandibular dentition.Once a day such scheme is advantageously used greater than about one month, one and a half months, two months, four months, six months, 12 months, 18 months, 2 years, 5 years, 8 years, 10 years, and/or less than about 15 years, 10 years, 8 years, 5 years, 2 years, 18 months, 12 months, six months, four months, two months, one and a half months and their any combination.Typically, the product 10 and/or 20 that is provided in the cover box can be used for upper jaw bone and mandibular bone.When the tooth products applied, all can from the cover box, take new product or not used product at every turn.
In another embodiment of the invention, the cover box comprises a plurality of products 10 and/or 20, and wherein each has different oral care active concentration.In each cover box the concentration of active substance by the weight of described oral care composition about 1% to about 25% scope.Concentration difference between the good product of cover box intermediate package by the weight of described oral care composition greater than about 1%, 2%, 3%, 4%, 5%, 6%, 10%, 15%, 20%, and/or less than about 20%, 15%, 10%, 9%, 8%, 7%, 6%, 5% or 4% and their any combination.For example, described cover box can comprise one or more following products: the concentration of hydrogen peroxide that has is counted about 4% first product by the weight of described oral care composition, the concentration of hydrogen peroxide that has is counted about 8% second product 10 and/or 20 by the weight of described oral care composition, the concentration of hydrogen peroxide that has is counted about 12% three products by the weight of described oral care composition and the concentration of hydrogen peroxide that has is counted about 16% four-product by the weight of described oral care composition.Use described product, to increase the concentration of oral care active.For example, user can use first product, second product, three products and four-product successively.The method can reduce the hemodia effect of being followed when using the product that comprises higher concentration oral care active such as hydrogen peroxide.Available literal or figure will overlap the packing that comprises first product, second product, three products and four-product in the box encodes, to show their preferred use order (as color coding or figure denote).
For sustainable greater than about 1 day and/or less than for about 5 years scheme that relates to a single set of box, expectation will have the product of teeth whitening active substance and oral care active combination and use at least about 1 time, 2 times, 3 times, 4 times, 5 times, 6 times, 7 times or 8 times, and/or, wherein every day new product is used on tooth about 1 time, 2 times, 3 times, 4 times and/or 5 times and their any combination less than about 20 times, 18 times, 16 times, 14 times, 12 times or 10 times.
Also the oral care product that comprises oral care active is used in expectation, and wherein said active substance is a peroxide compositions.These products that comprise peroxide can be administered on tooth and/or the oral soft tissue.But every day these products are used on required oral surfaces about 1 time, 2 times, 3 times and/or less than about 3 times, 2 times.In one embodiment, described product can be administered to a plurality of teeth to lingual surface with on buccal surface.In another embodiment, can only described product be administered to gum area, in another embodiment, described product can be administered on tooth and the gum area.This product can be used on oral surfaces greater than about 1 minute, 2 minutes, 3 minutes, 4 minutes, 5 minutes, 6 minutes, 7 minutes, 8 minutes, 9 minutes, 10 minutes, and less than about 10 minutes, 9 minutes, 8 minutes, 7 minutes, 6 minutes, 5 minutes, 4 minutes, 3 minutes, 2 minutes and their any combination.Such scheme at least once advantageously can be used greater than about one month, two months, four months, six months, 12 months, 18 months, 2 years, 5 years, 8 years, 10 years every day, and/or less than about 15 years, 10 years, 8 years, 5 years, 2 years, 18 months, 12 months, six months, four months, two months, one month and their any combination.The cover box can comprise the supply of the product 10 that is used for denture and mandibular dentition and/or 20 1 months, two months, three months, four months, five months, six months or 12 months.In one embodiment, the cover box comprises greater than about 10,20,30,40,50,60,70,80,90,120 joint strips, and/or less than about 730,365,200,185,150,120,90,80,70,60,50,40,30,20 joint strips and their any combination.
The relevant portion of all documents is incorporated herein with way of reference in the detailed Description Of The Invention.Quoting of any document may not be interpreted as its approval as prior art of the present invention.
Obviously being noted that can be with any feature, aspect or the details of any method as herein described and/or product or fully or partly combined with any further feature, aspect or the details of one or more other methods as herein described or product.
Although illustrated and described the present invention with specific embodiments, it will be apparent to those skilled in the art that and to make many other variation and modifications in the case of without departing from the spirit and scope of protection of the present invention.Therefore, in additional claims, comprise all such changes and modifications in the scope of the invention consciously.
Claims (10)
1. method of sending one or more mouth care beneficial effects to oral surfaces, described method comprises and will comprise that substrate and the product that comprises the oral care composition of oral care active are administered on a plurality of teeth and the contiguous soft tissue, be characterised in that described product at least once was administered on a plurality of teeth and the contiguous soft tissue at least about five minutes every day at every turn, wherein described product is administered to every day on described tooth and the contiguous soft tissue altogether greater than about six months time, and wherein at every turn use all use not used product.
2. the method for claim 1, wherein said oral care active is the teeth whitening active substance, preferably wherein said teeth whitening active substance is a peroxide.
3. method as claimed in claim 2, wherein said oral care composition comprises by the weight of described total composition less than 7.5% peroxide, preferably wherein said oral care composition comprises by the weight of described total composition greater than about 6.5% peroxide, and by the weight of described total composition less than 7.5% peroxide, and have less than about 1.3mg/cm
2Peroxide density.
4. method as claimed in claim 3, wherein said oral care composition comprise by the weight of described total composition greater than about 6% peroxide and by the weight of described total composition less than about 6.5% peroxide, and have less than about 1.3mg/cm
2Peroxide density.
5. method that reduces the tartar on the hard surface of oral cavity, described method comprises that the product that will comprise substrate and one or more oral care compositions is administered on described tooth and the contiguous soft tissue, at least a anti-calculus active matter that comprises in the wherein said oral care composition, be characterised in that described product at least once was administered on described tooth and the contiguous soft tissue at least about five minutes every day at every turn, wherein described product is administered to every day on described tooth and the contiguous soft tissue altogether greater than the trimestral approximately time, and wherein at every turn use all use not used product.
6. method as claimed in claim 6 wherein is administered to described product on described tooth and the contiguous soft tissue altogether greater than about six months time every day.
7. method as claimed in claim 6, at least a teeth whitening active substance that comprises in the wherein said oral care composition, preferably wherein said teeth whitening active substance is a peroxide.
8. method as claimed in claim 7, at least a in the wherein said oral care composition comprises teeth whitening active substance and anti-calculus active matter simultaneously, and wherein said oral care composition comprises by the teeth whitening active substance of the weight 1% to 30% of described total composition with by the anti-calculus active matter of the weight 0.5% to 3% of described total composition.
9. method as claimed in claim 8, wherein said teeth whitening active substance is a peroxide, and wherein said anti-calculus active matter is phosphate, preferably wherein said phosphate is pyrophosphate.
10. method as claimed in claim 7, wherein said product comprises two kinds of oral care compositions, a kind of teeth whitening active substance that comprises in the wherein said oral care composition, and the another kind in the described oral care composition comprises anti-calculus active matter, and wherein said oral care composition is spaced apart compositions and separates.
Applications Claiming Priority (4)
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| US70177805P | 2005-07-22 | 2005-07-22 | |
| US60/701,778 | 2005-07-22 | ||
| US60/750,455 | 2005-12-15 | ||
| US11/455,469 | 2006-06-19 |
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| CN101663017A true CN101663017A (en) | 2010-03-03 |
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| CN200680022969A Pending CN101663017A (en) | 2005-07-22 | 2006-07-21 | Oral care products |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107743386A (en) * | 2015-06-05 | 2018-02-27 | 荷兰联合利华有限公司 | Oral care appliance |
| CN109922866A (en) * | 2016-10-26 | 2019-06-21 | 宝洁公司 | Kit for tooth whitening |
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2006
- 2006-07-21 CN CN200680022969A patent/CN101663017A/en active Pending
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| CN107743386A (en) * | 2015-06-05 | 2018-02-27 | 荷兰联合利华有限公司 | Oral care appliance |
| US10595976B2 (en) | 2015-06-05 | 2020-03-24 | Conopco Inc. | Oral care device |
| CN109922866A (en) * | 2016-10-26 | 2019-06-21 | 宝洁公司 | Kit for tooth whitening |
| US11147753B2 (en) | 2016-10-26 | 2021-10-19 | The Procter & Gamble Company | Multi-phase oral composition for tooth whitening |
| US11253442B2 (en) | 2016-10-26 | 2022-02-22 | The Procter & Gamble Company | Kit for tooth whitening |
| US11259998B2 (en) | 2016-10-26 | 2022-03-01 | The Procter & Gamble Company | Multi-phase oral composition |
| US11266581B2 (en) | 2016-10-26 | 2022-03-08 | The Procter & Gamble Company | Electromagnetic radiation source and multi-phase oral composition for oral care use |
| US11278476B2 (en) | 2016-10-26 | 2022-03-22 | The Procter & Gamble Company | Electromagnetic radiation and delivery carrier for oral care |
| US11878068B2 (en) | 2016-10-26 | 2024-01-23 | The Procter & Gamble Company | Electromagnetic radiation and delivery carrier for oral care |
| US11938206B2 (en) | 2016-10-26 | 2024-03-26 | The Procter & Gamble Company | Electromagnetic radiation and multi-phase oral compositions for oral care |
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