CN101650363A - Rapid co-detection device of sample - Google Patents
Rapid co-detection device of sample Download PDFInfo
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- CN101650363A CN101650363A CN200910060091A CN200910060091A CN101650363A CN 101650363 A CN101650363 A CN 101650363A CN 200910060091 A CN200910060091 A CN 200910060091A CN 200910060091 A CN200910060091 A CN 200910060091A CN 101650363 A CN101650363 A CN 101650363A
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Abstract
The invention discloses a rapid co-detection device of a sample, which comprises a sample sucking head (1) and a detection pipe (2) which is sleeved at the rear end of the sample sucking head (1). Thefront end of the sample sucking head (1) is provided with a slim-tube suction nozzle (3) on which a rubber protective cap (5) can be sleeved. The device is internally provided with a test bar attached column (6), and the surface of the column body of the test strip attached column (6) is provided with one to more detection test bars (7), wherein shell parts of the detection pipe corresponding toa detection display area (12) and a mounting mark area (14) of each test bar are transparent. The tail end of the detection pipe is provided with a sealing cover (19) which seals waste materials afterdetection into the detection pipe (2). Various indexes of the sample can be simultaneously detected at a time by naked eyes within several minutes by the one-time sample suction and the isomesic detection of the test bars in the device, thus various detections of the sample become simpler, safer and quicker, and cross interferences are also avoided. Meanwhile, the waste materials after the detection are also sealed in the detection pipe so as to be more beneficial to avoiding the spread of pathogens and iatrogenic infections and treating the waste materials in an environment-friendly mode.
Description
Technical field
The present invention relates to medicine equipment and sample joint inspection strip, particularly a kind of rapid co-detection device of sample.
Background technology
Colloidal gold immunochromatographimethod technology (Gold-Immunochromatography Assay, GICA) be an immunolabelling technique that on the basis of ELISA adsorption analysis method (ELISA), grows up, it is carrier with the miillpore filter, utilize the capillarity of miillpore filter, the fluid sample that is applied to film bar one end is slowly oozed to the miillpore filter other end to be moved, if specific antigen or antibody are arranged in the liquid, they can with the immunity gold in conjunction with after again be fixed on miillpore filter on corresponding antibodies or antigen combine and show immune golden color.This technology simply, fast, does not need any instrument and equipment, and a few minutes result that just can detect by an unaided eye is called " concentrated ELISA " by praise, now be widely used in all aspects of immunology detection.
Chinese patent application number: 200710050163.0 and Chinese patent ZL200720081309.3 disclosed a kind of portable sample rapid joint inspection device based on the colloidal gold immunochromatographimethod strip.The suction head inner chamber of this Patent equipment is filled with sample filtering material and sample absorbent material, and during this co-detection device of suitability for industrialized production, purchasing and assembling of these materials increased production cost, and makes the sample joint inspection process can't be really quick.For solving above-mentioned deficiency, the present invention discloses and saves sample filtering material and sample absorbent material in a kind of suction head, detects the rapid co-detection device of sample that does not influence the result.
Summary of the invention
Technical scheme of the present invention is:
Described rapid co-detection device of sample, comprise suction head 1 and the detector tube 2 that is socketed in suction head 1 rear end, suction head 1 front end has tubule suction nozzle 3, suction nozzle 3 has the sample suction port 4 that is used to inhale sample, suction nozzle 3 front ends can be with rubber helmet 5, the built-in strip attached column 6 of described device, there is the 1 vertical shallow grooves of bar at the most on the shaft surface of described strip attached column 6, each shallow grooves internal fixation has a galley proof product examine test-strips 7, before the device, before the inwall of back segment is fit to locate to be provided with strip attached column 6, screens 8 is ended in the rear end, 9, the sample suction end 10 of the various kinds product examine test-strips 7 in strip attached column 6 grooves borrows strip attached column 6 can be drawn to sample to be checked smoothly, it is transparent 17,18 that the detection of each strip colour developing district 12 and strip are installed logo area 14 pairing that part of detector tube shells, Device Testing pipe tail end have the capping 19 will to detect afterwards discarded object is enclosed in the detector tube 2.
The strip 7 that divides groove to be fixed in the strip attached column 6 surperficial shallow grooves can be any sample detection strip.
Divide groove to be fixed on strip 7 its sample suction ends 10 in the strip attached column 6 surperficial shallow grooves, be followed successively by label pad district 11 thereafter, detect colour developing district 12, strong adsorptive pads district 13 and logo area 14 is installed preceding.
The detection colour developing district 12 sample detection line 15 and the sample nature controlling lines 16 of being provided with separated by a distance of each strip 7, wherein detection line 15 is positioned at before the nature controlling line 16, and detection line 15 can be 1, also can be many.
The tail end capping 19 of the shell of detector tube 2 and detector tube can be that plastics are made.
Described co-detection device can be cylinder type, flat cylinder-type, rectangular build, prismatic build or other cylinder-type.
The sample to be checked that described rapid co-detection device of sample was suitable for can be from clinical or non-clinical blood (comprising whole blood, serum, blood plasma), body fluid, urine, saliva, genital secretion or other liquid samples or thick sample.Wherein clinical sample comprises the sample of infectious disease, hormone, cardiovascular disease, tumour, diabetes, autoimmunity disease etc.; Non-clinical sample comprises the sample of food inspection, environmental pollution detection, biological contamination detection, biopreparate detection, veterinary science detection, drugs detection etc.
The method of operating of co-detection device of the present invention is:
(1) takes out rapid co-detection device of sample;
(2) remove the device headgear lid 20 of described device and the rubber cap bag 5 of suction head front end, expose sample suction port 4, and suction nozzle 3 be impregnated in the inspection product;
(3) in a few minutes, the built-in strip band in sample colour developing district of observing described device detector tube transparent plastic shell manifests situation, judges each index yin and yang attribute testing result of inspection product.
When suction nozzle 3 impregnated in sample to be checked, the sample suction end 10 of various kinds product examine test-strips can at first touch sample in the device, strip sample suction end 10 fluid samples can utilize the miillpore filter capillarity slowly to ooze to each strip rear end and move under strong adsorptive pads 13 pullings of strip tail end.If specific antigen or antibody are arranged in the fluid sample, just they with after the immunity gold in label pad district 11 combines again be fixed on each strip detection line 15 on corresponding antibodies or antigen combines and combine with Quality Control thing on the nature controlling line 16 and show immune golden color.Each strip is carried out and is divided groove reaction and quality control in the device, and detection is not disturbed mutually, thereby realizes the joint inspection of sample many index.
Particular problem to be solved by this invention:
The invention provides and save sample filtering material and sample absorbent material in a kind of suction head, detect the rapid co-detection device of sample that does not influence the result.
Beneficial effect of the present invention:
(1) sample filtering material and sample filtering material in application number patent 200710050163.0 and the described portable sample rapid joint inspection device suction head of the patent No. ZL200720081309.3 inner chamber have been saved, make the sample joint-detection more quick, and very the back apparatus structure is simpler, cost is cheaper, is more suitable for suitability for industrialized production.
(2) once inhale sample, with background parallel detection sample many index, the sample many index is detected become simpler, safe, fast.
(3) each strip is carried out reaction of branch groove and quality control in the device, has avoided the detection cross interference.
(4) operating personnel only need take off the rubber helmet of device headgear lid and suction head front end, and the suction nozzle that will expose impregnated in sample, in a few minutes, just can observe directly each sample detection result in detector tube shell clear area.In the detection, operating personnel directly do not contact the inspection product, detect the back discarded object and still are enclosed in the detector tube at last, have avoided inspection product pathogen to disseminate and hospital-acquired infection, more help environmental requirement and offal treatment.
(5) described device is easy and simple to handle, and is easy to carry, available immediately.Manipulating does not need special study and training, and professional and technical personnel and ordinary person all can use.Testing result is not subjected to restrictions such as instrument and equipment, environmental baseline.
(6) have wide range of applications, can according to circumstances built-in all kinds of sample detection strips in the device, detect to be used for various biomedical indexs.Comprise that clinical and non-clinical sample such as infectious disease, hormone, cardiovascular disease, tumour, autoimmunity disease, drugs, food security, persticide residue, environmental pollution, biological contamination, biopreparate, veterinary science, medical jurisprudence detects.
(7) reagent and material do not relate to active inactivation in the device, can be in the room temperature long preservation.
Description of drawings
Fig. 1 is the topology view of rapid co-detection device of sample preferred version one of the present invention.
Fig. 2 is the topology view of rapid co-detection device of sample preferred version two of the present invention.
Fig. 3 is the topology view of rapid co-detection device of sample preferred version three of the present invention.
Fig. 4 is the topology view of rapid co-detection device of sample preferred version four of the present invention.
Sequence number is: 1, suction head; 2, detector tube; 3, suction nozzle; 4, sample suction port; 5, rubber helmet; 6, strip attached column; 7, strip; 8, front end ends screens; 9, screens is ended in the rear end; 10, strip sample suction end; 11, strip label pad district; 12, strip detects the colour developing district; 13, the strong adsorptive pads of strip district; 14, strip is installed logo area; 15, detection line; 16, nature controlling line; 17, detector tube shell clear area; 18, detector tube shell clear area; 19, detector tube tail end capping; 20, device headgear lid; 21, hang not
Embodiment
Following embodiment further specifies the design feature of co-detection device of the present invention and manipulates method.Special needs to be pointed out is that co-detection device of the present invention also can have other improvement, therefore all to any technical scheme that is equal to replacement or the formation of equivalent transformation form of co-detection device employing of the present invention, all drop in the protection domain of claim of the present invention.
Fig. 1 is the topology view of rapid co-detection device of sample preferred version one of the present invention.Described device comprises suction head 1 and is socketed in the detector tube 2 of suction head 1 rear end.Suction head 1 front end has tubule suction nozzle 3.Suction nozzle 3 has the sample suction port 4 that is used to inhale sample.Suction nozzle 3 front ends can be with rubber helmet 5, take off rubber helmet 5 during detection, expose sample suction port 4, suction nozzle 3 be impregnated in the inspection product can carry out the sample joint inspection.The built-in strip attached column 6 of described device, the shaft surface of described strip attached column 6 have the 1 vertical shallow grooves of bar at the most, and each shallow grooves internal fixation has a galley proof product examine test-strips 7.The inwall of device front and rear sections is fit to locate to be provided with strip attached column 6 front and back ends and ends screens 8,9.The sample suction end 10 of various kinds product examine test-strips 7 its front ends in strip attached column 6 grooves borrows strip attached column 6 can be drawn to sample to be checked smoothly.It is transparent 17,18 that the detection of each strip colour developing district 12 and strip are installed logo area 14 pairing that part of detector tube shells, during sample detection, but the band colour developing result by each strip in these detector tube shell clear area 17 Direct observation auto levelizers.Discarded object was enclosed in the detector tube 2 after Device Testing pipe tail end had capping 19 to detect.
The strip 7 that divides groove to be fixed in the strip attached column 6 surperficial shallow grooves can be any sample detection strip.
Divide groove to be fixed on strip 7 its sample suction ends 10 in the strip attached column 6 surperficial shallow grooves, be followed successively by label pad district 11 thereafter, detect colour developing district 12, strong adsorptive pads district 13 and logo area 14 is installed preceding.
Detection colour developing district 12 a galley proof product detection line 15 and the galley proof product nature controlling lines 16 of being provided with separated by a distance of each strip 7, wherein detection line 15 is positioned at before the nature controlling line 16.
The shell of the detector tube 2 of described co-detection device and the tail end capping 19 of detector tube can be that plastics are made.
Fig. 2 is the topology view of rapid co-detection device of sample preferred version two of the present invention.It is on the priority scheme shown in Figure 1 basis, encloses device headgear lid 20 and the co-detection device scheme of formation at its suction head 1 one ends again.This device headgear lid 20 is provided with portable extension other 21.Device headgear lid 20 can be made by plastic material, metal material or other material.
Fig. 3 is the topology view of rapid co-detection device of sample preferred version three of the present invention.In the described scheme, divide groove to be fixed on that its detection line 15 locations of strip in the device are separated by a distance to be provided with two above detection lines, each detection line detects at a kind of sample index respectively.Use many detection lines co-detection device shown in Figure 3 can realize the more high flux joint inspection of sample index.
Fig. 4 is the topology view of rapid co-detection device of sample preferred version four of the present invention.It is on the priority scheme shown in Figure 3 basis, encloses device headgear lid 20 and the co-detection device scheme of formation at its suction head 1 one ends again.It is other 21 to be provided with portable extension on this device headgear lid 20, and device headgear lid 20 can be made by plastic material, metal material or other material.
Its overall appearance of above-mentioned co-detection device (comprising Fig. 1, Fig. 2, Fig. 3, the described co-detection device of Fig. 4 scheme) can be cylinder type, flat cylinder-type, rectangular build, prismatic build or other cylinder-type.
The sample to be checked that above-mentioned co-detection device (comprising Fig. 1, Fig. 2, Fig. 3, the described co-detection device of Fig. 4 scheme) is suitable for can be from clinical or non-clinical blood (comprising whole blood, serum, blood plasma), body fluid, urine, saliva, genital secretion or other liquid samples or thick sample.Wherein clinical sample comprises the sample of infectious disease, hormone, cardiovascular disease, tumour, diabetes, autoimmunity disease etc.; Non-clinical sample comprises the sample of food inspection, environmental pollution detection, biological contamination detection, biopreparate detection, veterinary science detection, drugs detection etc.
The method of manipulating of described co-detection device (comprising Fig. 1, Fig. 2, Fig. 3, the described co-detection device of Fig. 4 scheme) is:
(1) takes out rapid co-detection device of sample;
(2) remove the device headgear lid 20 of described device and the rubber cap bag 5 of suction head front end, expose sample suction port 4, and suction nozzle 3 be impregnated in the inspection product;
(3) in a few minutes, the built-in strip band in sample colour developing district of observing described device detector tube transparent plastic shell manifests situation, judges each index yin and yang attribute testing result of inspection product.
Claims (10)
1. rapid co-detection device of sample, it is characterized in that: it comprises suction head (1) and is socketed in the detector tube (2) of suction head (1) rear end, suction head (1) front end has tubule suction nozzle (3), suction nozzle (3) has the sample suction port (4) that is used to inhale sample, suction nozzle (3) front end can be with rubber helmet (5), the built-in strip attached column (6) of described device, there is the 1 vertical shallow grooves of bar at the most on the shaft surface of described strip attached column (6), each shallow grooves internal fixation has a galley proof product examine test-strips (7), before the device, it is preceding that the inwall of back segment is fit to locate to be provided with strip attached column (6), screens (8 is ended in the rear end, 9), the sample suction end (10) of the various kinds product examine test-strips (7) in strip attached column (6) groove borrows strip attached column (6) can be drawn to sample to be checked smoothly, it is transparent (17 that the detection colour developing district (12) of each strip and strip are installed the pairing that part of detector tube shell of logo area (14), 18), discarded object was enclosed in the detector tube (2) after Device Testing pipe tail end had capping (19) to detect.
2. rapid co-detection device of sample according to claim 1 is characterized in that: the strip (7) that divides groove to be fixed in the shallow grooves of strip attached column surface can be any sample detection strip.
3. rapid co-detection device of sample according to claim 1, it is characterized in that: divide groove to be fixed on its sample suction end of strip (7) (10) in the shallow grooves of strip attached column surface, be followed successively by label pad district (11) thereafter, detect colour developing district (12), strong adsorptive pads district (13) and installation logo area (14) preceding.
4. according to claim 1 or 3 described rapid co-detection device of sample, it is characterized in that: detection colour developing district (12) sample detection line (15) and sample nature controlling line (16) of being provided with separated by a distance of each strip (7), wherein detection line (15) is positioned at nature controlling line (16) before, detection line (15) can be 1, also can be many.
5. rapid co-detection device of sample according to claim 1 is characterized in that: the tail end capping (19) of the shell of detector tube (2) and detector tube can be that plastics are made.
6. rapid co-detection device of sample according to claim 1 is characterized in that: suction head (1) shell can be that metal material or plastic material are made.
7. rapid co-detection device of sample according to claim 1 is characterized in that: described device can be cylinder type, flat cylinder-type, rectangular build, or prismatic build.
8. rapid co-detection device of sample as claimed in claim 1 is characterized in that: suction head (1) one end of described device also can be with device headgear lid (20) outward, can be provided with portable extension other (21) on this device headgear lid (20).
9. rapid co-detection device of sample according to claim 8 is characterized in that: the device headgear lid (20) of described co-detection device suction head (1) one end can be made by plastic material or metal material.
10. one kind as claim 1 or the described rapid co-detection device of sample of claim 8, it is characterized in that: sample to be checked can be from clinical or non-clinical blood, body fluid, urine, saliva, genital secretion or other liquid samples or thick sample, wherein clinical sample comprises the sample as infectious disease, hormone, cardiovascular disease, tumour, diabetes, autoimmunity disease etc., and non-clinical sample comprises the sample of food inspection, environmental pollution detection, biological contamination detection, biopreparate detection, veterinary science detection, drugs detection etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910060091A CN101650363A (en) | 2009-07-23 | 2009-07-23 | Rapid co-detection device of sample |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910060091A CN101650363A (en) | 2009-07-23 | 2009-07-23 | Rapid co-detection device of sample |
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| CN101650363A true CN101650363A (en) | 2010-02-17 |
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|---|---|---|---|
| CN200910060091A Pending CN101650363A (en) | 2009-07-23 | 2009-07-23 | Rapid co-detection device of sample |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105158452A (en) * | 2015-09-22 | 2015-12-16 | 山东耀华医疗器械股份有限公司 | Urine test paper health test bar integrating preservation and detection |
| CN106053456A (en) * | 2016-06-24 | 2016-10-26 | 许毅 | Urine concentrating device |
| CN106119099A (en) * | 2016-06-14 | 2016-11-16 | 西安交通大学 | A kind of totally-enclosed many targeting nucleic acid isothermal amplification detection integrated apparatus |
| CN106645663A (en) * | 2017-01-22 | 2017-05-10 | 英科新创(厦门)科技有限公司 | Anti-pollution vertical tomography detection device |
-
2009
- 2009-07-23 CN CN200910060091A patent/CN101650363A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105158452A (en) * | 2015-09-22 | 2015-12-16 | 山东耀华医疗器械股份有限公司 | Urine test paper health test bar integrating preservation and detection |
| CN106119099A (en) * | 2016-06-14 | 2016-11-16 | 西安交通大学 | A kind of totally-enclosed many targeting nucleic acid isothermal amplification detection integrated apparatus |
| CN106053456A (en) * | 2016-06-24 | 2016-10-26 | 许毅 | Urine concentrating device |
| CN106053456B (en) * | 2016-06-24 | 2018-11-27 | 许毅 | A kind of urine enrichment facility |
| CN106645663A (en) * | 2017-01-22 | 2017-05-10 | 英科新创(厦门)科技有限公司 | Anti-pollution vertical tomography detection device |
| CN106645663B (en) * | 2017-01-22 | 2023-07-18 | 英科新创(厦门)科技股份有限公司 | Anti-pollution vertical chromatography detection device |
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Application publication date: 20100217 |