CN101637588A - Chinese medicinal preparation for treating hysteromyoma and preparation process thereof - Google Patents

Abstract

The invention discloses a Chinese medicinal preparation for treating hysteromyoma and a preparation process thereof. The Chinese medicinal preparation uses astragalus root, liquorice root, bistort rhizome, pilose asiabell root, sanchi, Chinese angelica, common burreed rubber, zedoray, largehead atractylodes rhizome, immature orange fruit, white peony root, rangooncreeper fruit, indian buead and green tangerine peel as raw materials; the raw materials are prepared into extract through extracting, concentrating, drying and crushing; and the extract is added with auxiliary materials to prepare tablets, capsules, granules and the like. The medicament has the functions of activating blood to remove stasis, softening hardness to dissipate stagnation, and supporting healthy energy, and is used for treating the hysteromyoma which is caused by qi stagnation induced blood stasis and has the symptoms of menostaxis, hypermenorrhea, dark purple menstrual flow, distended pain in underbelly or breastand the like. Efficacy trials prove that the medicament has the effect of resisting tumor and uterine leiomyoma, and has no toxic or side effect.

Description

A kind of Chinese medicine preparation and preparation technology thereof who treats hysteromyoma

Technical field

The invention belongs to the Chinese medicine preparation technical field, be specifically related to a kind of Chinese medicine preparation and preparation technology thereof who treats hysteromyoma.

Technical background

Hysteromyoma is the benign tumor that uterine smooth muscle hamartoplasia forms, be mainly in the vigorous childbearing age women of ovarian function, 30～50 years old women accounts for 70%～80%, be most common tumor in the female reproductive system, and it falls ill ascendant trend year by year.Though hysteromyoma direct life of harm patient unlike malignant tumor, women's health in its menorrhagia that causes, stomachache, irregular vagina bleeding, anemia even serious threat such as infertile.

Most hysteromyoma non-evident symptons are only found when pelvioscopy, and muscular tumor is not of uniform size fixed and symptom is proportional. and closely related with growth site.According to the difference at position, its symptom is having a strong impact on women's quality of life based on vaginal hemorrhage, abdominal mass, leucorrhoea grow in quantity, pain and sterility and infertility etc.Primary disease belongs to the category of the traditional Chinese medical science " abdominal mass ", and is just on the books as far back as " element is asked the bone empty talk ", is loaded with prescription---the Ramulus Cinnamomi Poria pill of first treatment addiction abdominal mass in " Medical Treasures of the Golden Chamber ".In recent years, hysteromyoma is paid attention to by people day by day, and Chinese medicine is also constantly developed on the forefathers basis.

By Gu so far, most of physicians think that generation, development and the blood stasis of hysteromyoma have substantial connection, think that blood stasis stops poly-uterus, with the passing of time becomes the scar abdominal mass and gathers.The formation of blood stasis is multifactorial, mainly be divided into 5 types clinically according to its origin cause of formation: qi stagnation and blood stasis type: lower abdomen has caking, abdominal distention and pain or twinge, the confusion of the menstrual cycle, many through blood volume, the dim red piece that has, through the fore udder distending pain, vexed uncomfortable in chest, happiness is sighed, purplish tongue is dim or the ecchymosis petechia is arranged, and sublingual vessel is angry to be opened or livid purple nodosity, hesitant pulse or string.Method of treatment is the regulating QI and promoting blood circulation to remove blood stasis eliminating stagnation, and main formula is added and subtracted with XIAOYAO POWDER.Qi deficiency blood stasis type: lower abdomen weighs down pain, and caking is arranged in the abdomen, preceeded menorrhea, and the amount polychrome is light or dripping more than, and matter is thin, and clot is arranged, profuse leukorrhea, the color white matter is rare, limbs fatigue, shallow complexion, pale tongue, white and thin fur, the sublingual vessel color is light red, deficient pulse and puckery.Method of treatment is the benefiting qi and removing blood stasis eliminating stagnation, and main formula is added and subtracted with BAZHEN TANG; Cold blood stasis type: lower abdomen has caking, and cold and pain in the lower abdomen is met cold increasing the weight of, pain alleviated while getting warmth, delayed menstrual cycle, the few darkish complexion of amount has clot, profuse leukorrhea, the color white matter is rare, brothers' cold, light red tongue is dim, white and thin fur, and angry of sublingual vessel is tortuous, color is pale purple, deep and tense pulse, and method of treatment is a dispelling cold by warming the meridian, blood stasis-eliminating and stagnation-dissipating, main formula is added and subtracted with SHAOFU ZHUYN DECOCTION; Intermingled phlegm and blood stasis type: breast gastral cavity painful abdominal mass is vexed, and caking is arranged in the abdomen, menorrhagia, and color is dim red, and matter is sticky, and clot is arranged, profuse leukorrhea, the color white matter is glutinous, and enlarged tongue is big, and indentation is arranged, and the color purple is dim, and tongue is greasy in vain, and the livid purple anger of sublingual vessel is opened deep-rolling pulse.Method of treatment is that regulating the flow of QI to dissipate blood stasis eliminates the phlegm, and main formula is added and subtracted with Ramulus Cinnamomi Poria pill; The intenseness of heat blood stasis type: caking is arranged in the abdomen, preceeded menorrhea, the many or dripping urine endlessly of amount, deep red menses or purple black has clot, the xerostomia thirst and desire for cold drink, the body of the tongue purple is dim, yellow fur, tortuous or angry of sublingual vessel, color is livid purple or dim red.Method of treatment is the heat clearing and blood stasis dispersing eliminating stagnation, and main formula closes clearly through the plus-minus that looses with SIWU TANG.

Summary of the invention

The object of the invention is to provide a kind of Chinese medicine preparation and preparation technology thereof who treats hysteromyoma, to remedy the deficiency of existing medicine.

Be achieved through the following technical solutions order of the present invention:

1, the present invention is made by the following weight proportion raw material:

20～60 parts of 60～120 portions of Rhizoma Bistortaes of 40～80 portions of Radix Glycyrrhizaes of the Radix Astragali

60～120 parts of 10～30 parts of Radix Angelicae Sinensis of 40～80 portions of Radix Notoginseng of Radix Codonopsis

40～80 parts of 40～80 parts of Rhizoma Atractylodis Macrocephalaes of 60～120 parts of Rhizoma Curcumae of rhizoma sparganic

20～60 parts of 20～60 parts of Fructus Quisqualis of 40～80 portions of Radix Paeoniae Albas of Fructus Aurantii Immaturus

100～150 parts on 60～120 parts of Pericarpium Citri Reticulatae Virides of Poria

2, best each the raw material weight proportioning of the present invention is:

45 parts of 100 portions of Rhizoma Bistortaes of 65 portions of Radix Glycyrrhizaes of the Radix Astragali

100 parts of 25 parts of Radix Angelicae Sinensis of 65 portions of Radix Notoginseng of Radix Codonopsis

65 parts of 65 parts of Rhizoma Atractylodis Macrocephalaes of 100 parts of Rhizoma Curcumae of rhizoma sparganic

45 parts of 45 parts of Fructus Quisqualis of 65 portions of Radix Paeoniae Albas of Fructus Aurantii Immaturus

130 parts on 100 parts of Pericarpium Citri Reticulatae Virides of Poria

3, the preparation technology of this Chinese medicine preparation is:

(1) it is broken to get superfine notoginseng powder, micropowder, standby;

(2) Radix Astragali, Radix Glycyrrhizae, Radix Codonopsis, rhizoma sparganic in the general side mix, and add 80% ethanol extraction 3 times, and each 1～2 hour (medicinal residues are standby), extracting solution merges, and filters, and filtrate decompression is condensed into heat survey relative density and is the clear paste of 1.12-1.19 (60 ℃), and is standby;

(3) all the other Rhizoma Bistortaes, Radix Angelicae Sinensis etc. nine are distinguished the flavor of, and add the alcohol extraction medicinal residues, mix, and decoct with water three times, decoct respectively 2,1.5,1 hours, and collecting decoction leaves standstill, and filter, and it is the clear paste of 1.15-1.22 (75 ℃) that filtrate is condensed into heat survey relative density, standby;

(4) alcohol extraction clear paste, water are carried clear paste and Radix Notoginseng micropowder mix homogeneously, drying gets dry extract, and adds conventional adjuvant, makes the dosage form of suitable clinical practices such as tablet, capsule, granule.

A kind of Chinese medicine preparation for the treatment of hysteromyoma disclosed by the invention be by the Radix Astragali, Radix Glycyrrhizae, Rhizoma Bistortae, Radix Codonopsis, Radix Notoginseng, Radix Angelicae Sinensis, rhizoma sparganic, Rhizoma Curcumae, the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii Immaturus, the Radix Paeoniae Alba, Fructus Quisqualis, Poria, Pericarpium Citri Reticulatae Viride totally ten four the flavor Chinese medicines be raw material, through extracting, concentrate, dry, pulverize and make extractum, add tablet that adjuvant makes, capsule, granule etc. again.This invention medicine has the effect of activating blood circulation to dissipate blood stasis, hard masses softening and resolving, strengthening the body resistance, is used for hysteromyoma qi stagnation blood stasis disease, and disease is seen menostaxis, and through measuring too much, dark menses has piece, lower abdomen or distending pain of the breast etc.Show that through the test of pesticide effectiveness medicine of the present invention has the effect of antitumor action, anti-leiomyoma of uterus, has no side effect.

The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.Following example is based on the above-mentioned subject area of the present invention, but is not limited to following example.

The specific embodiment

Embodiment 1: a kind of granule for the treatment of hysteromyoma

Adopt following prescription:

Radix Astragali 65g Radix Glycyrrhizae 100g Rhizoma Bistortae 45g

Radix Codonopsis 65g Radix Notoginseng 25g Radix Angelicae Sinensis 100g

Rhizoma sparganic 100g Rhizoma Curcumae 65g Rhizoma Atractylodis Macrocephalae 65g

Fructus Aurantii Immaturus 65g Radix Paeoniae Alba 45g Fructus Quisqualis 45g

Poria 100g Pericarpium Citri Reticulatae Viride 130g

The preparation technology of this Chinese medicine preparation is:

(1) it is broken to get superfine notoginseng powder, micropowder 25g, standby;

(2) Radix Astragali 65g, Radix Glycyrrhizae 100g, Radix Codonopsis 65g, rhizoma sparganic 100g in the general side mix, and add 80% ethanol extraction 3 times, and each 2 hours (medicinal residues are standby), extracting solution merges, and filters, and filtrate decompression is condensed into heat survey relative density and is the clear paste of 1.15 (60 ℃), and is standby;

(3) all the other Rhizoma Bistortaes, Radix Angelicae Sinensis etc. nine are distinguished the flavor of, and add the alcohol extraction medicinal residues, mix, and decoct with water three times, decoct respectively 2,1.5,1 hours, and collecting decoction leaves standstill, and filter, and it is the clear paste of 1.18 (75 ℃) that filtrate is condensed into heat survey relative density, standby;

(4) alcohol extraction clear paste, water are carried clear paste and Radix Notoginseng micropowder mix homogeneously, drying gets dry extract, and adds about 120g of starch and the about 19g of Pulvis Talci, makes granule with 80% ethanol, forced air drying, promptly.

Embodiment 2: a kind of capsule for the treatment of hysteromyoma

Adopt following prescription:

Radix Astragali 40g Radix Glycyrrhizae 60g Rhizoma Bistortae 20g

Radix Codonopsis 40g Radix Notoginseng 10g Radix Angelicae Sinensis 60g

Rhizoma sparganic 60g Rhizoma Curcumae 40g Rhizoma Atractylodis Macrocephalae 40g

Fructus Aurantii Immaturus 40g Radix Paeoniae Alba 20g Fructus Quisqualis 20g

Poria 60g Pericarpium Citri Reticulatae Viride 100g

The preparation technology of this Chinese medicine preparation is:

(1) it is broken to get superfine notoginseng powder, micropowder 10g, standby;

(2) Radix Astragali 40g, Radix Glycyrrhizae 60g, Radix Codonopsis 40g, rhizoma sparganic 60g in the general side mix, and add 80% ethanol extraction 3 times, and each 1 hour (medicinal residues are standby), extracting solution merges, and filters, and filtrate decompression is condensed into heat survey relative density and is the clear paste of 1.17 (60 ℃), and is standby;

(3) all the other Rhizoma Bistortaes, Radix Angelicae Sinensis etc. nine are distinguished the flavor of, and add the alcohol extraction medicinal residues, mix, and decoct with water three times, decoct respectively 2,1.5,1 hours, and collecting decoction leaves standstill, and filter, and it is the clear paste of 1.20 (75 ℃) that filtrate is condensed into heat survey relative density, standby;

(4) alcohol extraction clear paste, water are carried clear paste and Radix Notoginseng micropowder mix homogeneously, drying gets dry extract, and adds the about 75g of lactose, and mixing is adorned capsule No. 0, promptly.

Embodiment 3: a kind of tablet for the treatment of hysteromyoma

Adopt following prescription:

Radix Astragali 80g Radix Glycyrrhizae 120g Rhizoma Bistortae 60g

Radix Codonopsis 80g Radix Notoginseng 30g Radix Angelicae Sinensis 120g

Rhizoma sparganic 120g Rhizoma Curcumae 80g Rhizoma Atractylodis Macrocephalae 80g

Fructus Aurantii Immaturus 80g Radix Paeoniae Alba 60g Fructus Quisqualis 60g

Poria 120g Pericarpium Citri Reticulatae Viride 150g

The preparation technology of this Chinese medicine preparation is:

(1) it is broken to get superfine notoginseng powder, micropowder 30g, standby;

(2) Radix Astragali 80g, Radix Glycyrrhizae 120g, Radix Codonopsis 80g, rhizoma sparganic 120g in the general side mix, and add 80% ethanol extraction 3 times, each 1.5 hours (medicinal residues are standby), extracting solution merges, and filters, filtrate decompression is condensed into heat survey relative density and is the clear paste of 1.14 (60 ℃), and is standby;

(3) all the other Rhizoma Bistortaes, Radix Angelicae Sinensis etc. nine are distinguished the flavor of, and add the alcohol extraction medicinal residues, mix, and decoct with water three times, decoct respectively 2,1.5,1 hours, and collecting decoction leaves standstill, and filter, and it is the clear paste of 1.16 (75 ℃) that filtrate is condensed into heat survey relative density, standby;

(4) alcohol extraction clear paste, water are carried clear paste and Radix Notoginseng micropowder mix homogeneously, drying gets dry extract, and adding starch and dextrin ratio are 1: 3 the about 160g of mixture, mixing, and water is granulated, drying, compacting is in blocks, promptly.

Claims (3)

1, a kind of Chinese medicine preparation for the treatment of hysteromyoma is characterized in that it comprises that unit of weight makes by the following Chinese medicine of part:

20～60 parts of 60～120 portions of Rhizoma Bistortaes of 40～80 portions of Radix Glycyrrhizaes of the Radix Astragali

60～120 parts of 10～30 parts of Radix Angelicae Sinensis of 40～80 portions of Radix Notoginseng of Radix Codonopsis

40～80 parts of 40～80 parts of Rhizoma Atractylodis Macrocephalaes of 60～120 parts of Rhizoma Curcumae of rhizoma sparganic

20～60 parts of 20～60 parts of Fructus Quisqualis of 40～80 portions of Radix Paeoniae Albas of Fructus Aurantii Immaturus

100～150 parts on 60～120 parts of Pericarpium Citri Reticulatae Virides of Poria.

2, a kind of Chinese medicine preparation for the treatment of hysteromyoma as claimed in claim 1 is characterized in that the weight proportion of each component is:

45 parts of 100 portions of Rhizoma Bistortaes of 65 portions of Radix Glycyrrhizaes of the Radix Astragali

100 parts of 25 parts of Radix Angelicae Sinensis of 65 portions of Radix Notoginseng of Radix Codonopsis

65 parts of 65 parts of Rhizoma Atractylodis Macrocephalaes of 100 parts of Rhizoma Curcumae of rhizoma sparganic

45 parts of 45 parts of Fructus Quisqualis of 65 portions of Radix Paeoniae Albas of Fructus Aurantii Immaturus

130 parts on 100 parts of Pericarpium Citri Reticulatae Virides of Poria.

3, as the described a kind of Chinese medicine preparation for the treatment of hysteromyoma of claim 1-2, it is characterized in that the preparation technology of this Chinese medicine preparation is:

(1) it is broken to get superfine notoginseng powder, micropowder, standby;

(2) Radix Astragali, Radix Glycyrrhizae, Radix Codonopsis, rhizoma sparganic in the general side mix, and add 80% ethanol extraction 3 times, and each 1～2 hour (medicinal residues are standby), extracting solution merges, and filters, and filtrate decompression is condensed into heat survey relative density and is the clear paste of 1.12-1.19 (60 ℃), and is standby;

(3) all the other Rhizoma Bistortaes, Radix Angelicae Sinensis etc. nine are distinguished the flavor of, and add the alcohol extraction medicinal residues, mix, and decoct with water three times, decoct respectively 2,1.5,1 hours, and collecting decoction leaves standstill, and filter, and it is the clear paste of 1.15-1.22 (75 ℃) that filtrate is condensed into heat survey relative density, standby;

(4) alcohol extraction clear paste, water are carried clear paste and Radix Notoginseng micropowder mix homogeneously, drying gets dry extract, and adds conventional adjuvant, makes the dosage form of suitable clinical practices such as tablet, capsule, granule.