CN101628881A - Substituted cyanoacetate compound and application thereof - Google Patents
Substituted cyanoacetate compound and application thereof Download PDFInfo
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- CN101628881A CN101628881A CN200810116762A CN200810116762A CN101628881A CN 101628881 A CN101628881 A CN 101628881A CN 200810116762 A CN200810116762 A CN 200810116762A CN 200810116762 A CN200810116762 A CN 200810116762A CN 101628881 A CN101628881 A CN 101628881A
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Abstract
The invention relates to a substituted cyanoacetate compound as shown in the general formula (I). In the general formula (I), all groups are defined as in the specification. The compound and the composition thereof can be used for preventing and controlling harmful mites and eggs of the harmful mites, and also can be used for preventing and controlling pests.
Description
Technical field：
The invention belongs to agricultural insecticidal, acaricide field, it is used for agriculturally preventing and treating arthropod (insect and mite) including the new substituted cyanoacetate compound of a class, and the purposes of worm (including nematode), specifically kind of cyanic acetate compounds and its application.
Background technology
Because the agricultural chemicals of a new generation must are fulfilled for many demands, for example be related to application dose, the drug effect phase, activity profile, application field, toxicity, with the combinations of other active materials and the combination or synthesis of processing aid and due to resistance for being likely to occur etc., and existing chemistry of pesticide product can not be all satisfactory in all application fields, therefore the exploitation of novel pesticide is always not over.People have higher demand to noval chemical compound, and performance at least in some aspects is better than known compound.
The acyl acetonitrile class compound containing phenyl ring with acaricidal activity has been disclosed in the prior art.For example United States Patent (USP) US200320808 discloses below formula (II) compound：
Lead to formula (III) compound disclosed in Japan Patent JP2003286265, JP2004115399, be that the part B in above-mentioned logical formula (II) by phenyl ring is become into pyrazolyl, structure is as follows：
The structural features that part A is phenyl ring are remained in that on this two classes compound structure.B ring portions are divided into phenyl ring and pyrazole ring.
In recent years, some acarids generate the resistance to the action of a drug for the acaricide being used for for many years, and this allows for being difficult to prevent and kill off them with traditional acaricide.Accordingly, it would be desirable to which the new acaricide of acarid can admirably be prevented and kill off by developing.
The content of the invention
An object of the present invention is to provide a kind of or even can also show that excellent acarid prevents and kill off the cyanoacetate compound of effect when low concentration is used.It is a further object to provide the purposes of class cyanoacetate compound preventing and treating arthropod, and worm.The purpose of the present invention also includes providing a kind of novel pesticide to mite class lasting period length and providing a kind of mite class for producing traditional acaricide resistance still have the novel pesticide of excellent activity.
These purposes can be provided simultaneously with or part possesses.
Technical scheme is as follows：
A kind of cyanoacetate compound, as shown in logical formula (I)：
In formula：
R1Selected from C1-C6Alkyl, C1-C6Haloalkyl, the C of phenyl substitution1-C6Alkyl, C2-C6Alkenyl, C2-C6Haloalkenyl group, C2-C6Alkynyl, C2-C6Halo alkynyl, C3-C7Cycloalkyl, C3-C7Halogenated cycloalkyl, vinyl halides base C3-C7Cycloalkyl, R6Or R7；
R2Selected from R8Or R9；
R3、R4、R5It is independently selected from CN, halogen or R17；
R6Selected from unsubstituted or substituted phenyl, described substituent is selected from 1-5 following radicals：Halogen, C1-C6- alkyl, C1-C6Haloalkyl, C1-C6Alkoxy, C1-C6Halogenated alkoxy, CN, NO2、SOnR17、COR17、COOR17、CONR17R18、SO2NR17R18Or OR17；
R7Selected from unsubstituted or substituted fragrant heterocyclic radical, described substituent is selected from one or more following radicals：Halogen, C1-C6Alkyl, C1-C6Haloalkyl, C1-C6Alkoxy, C1-C6Halogenated alkoxy, CN, NO2、SOnR16、COR16、COOR17、CONR17R18、SO2NR17R18、OR17Or halogenophenyl, described fragrant heterocyclic radical is selected from pyridine radicals, pyrimidine radicals, pyridazinyl, pyrazinyl, triazine radical, thienyl, thiazolyl, thiadiazolyl group, oxazolyl, isoxazolyls, furyl, pyrrole radicals, pyrazolyl, imidazole radicals, triazolyl or Isosorbide-5-Nitrae-oxygen thiapyran；
R8Selected from R6、R7、R10、R11、R12Or R13；
R9Selected from CHR14R15；
R10Selected from the R replaced with following groups16：R6Or R7；
R11Selected from the R replaced with following groups16：XR6Or XR7；
R12Selected from the R replaced with following groups16：COOR6、COOR7、CONR6R12、CONR7R17、SO2NR6R17、SO2NR7R17、NHSO2R6Or NHSO2R7；
R13It is selected from：
R14Selected from CN or R17；
R15Selected from CN, COOR17、CONR17R18、CH2CH2OCH3, nonaromatic heterocycles base or the C replaced by following groups1-C6Alkyl：CN、COOR17、CONR17R18、NR17R18、R19、OCH2CN、OCH2COOR16、OCH2CONR17R18、OCH2CF3、C3-C6Cycloalkyl oxy, C3-C6Cycloalkenyl oxy, C3-C6Non-aromatic heterocyclylalkyl epoxide, C3-C6Nonaromatic heterocycles alkenyl epoxide, C3-C6Cycloalkylsulfanyl, C3-C6Cycloalkenyl group sulfenyl, C3-C6Non-aromatic heterocyclylalkyl sulfenyl or C3-C6Nonaromatic heterocycles enylsulfanyl；Described nonaromatic heterocycles base is selected from tetrahydrofuran, thiophane, nafoxidine, tetrahydro-thiazoles, tetrahydro-pyrazole, imidazolidine, tetrahydrochysene triazole, hexahydropyridine or hexahydro pyrans；
R16Selected from C1-C6Alkyl, C1-C6Haloalkyl, C2-C6Alkenyl, C2-C6Haloalkenyl group, C2-C6Alkynyl, C2-C6Halo alkynyl or C3-C6- cycloalkyl；
R17、R18It is independently selected from hydrogen or R16；
R19It is selected from the P shown in lower1-P28In any one group：
X is selected from O, S or NR17；
N is 0-2 integer.
The present invention more preferred compound is：In logical formula (I)
R1Selected from C3-C7Halogenated cycloalkyl, vinyl halides base C3-C7Cycloalkyl, R6Or R7；
R2Selected from R8Or R9；
R3、R4、R5It is independently selected from CN, halogen or R17；
R6Selected from unsubstituted or substituted phenyl, described substituent is selected from 1-5 following radicals：Halogen, C1-C4- alkyl, C1-C4Haloalkyl, C1-C4Alkoxy, C1-C4Halogenated alkoxy, CN, NO2、SOnR17、COR17、COOR17、CONR17R18、SO2NR17R18Or OR17；
R7Selected from unsubstituted or substituted fragrant heterocyclic radical, described substituent is selected from 1-3 following radicals：Halogen, C1-C4Alkyl, C1-C4Haloalkyl, C1-C4Alkoxy, C1-C4Halogenated alkoxy, CN, NO2、SOnR16、COR16、COOR17、CONR17R18、SO2NR17R18、OR17Or halogenophenyl, described fragrant heterocyclic radical is selected from pyridine radicals, pyrimidine radicals, pyridazinyl, pyrazinyl, triazine radical, thienyl, thiazolyl, thiadiazolyl group, oxazolyl, isoxazolyls, furyl, pyrrole radicals, pyrazolyl, imidazole radicals, triazolyl or Isosorbide-5-Nitrae-oxygen thiapyran；
R8Selected from R6、R7、R10、R11、R12Or R13；
R9Selected from CHR14R15；
R10Selected from the R replaced with following groups16：R6Or R7；
R11Selected from the R replaced with following groups16：XR6Or XR7；
R12Selected from the R replaced with following groups16：COOR6、COOR7、CONR6R12、CONR7R17、SO2NR6R17、SO2NR7R17、NHSO2R6Or NHSO2R7；
R13It is selected from：
R14Selected from CN or R17；
R15Selected from CN, COOR17、CONR17R18、CH2CH2OCH3, nonaromatic heterocycles base or the C replaced by following groups1-C4Alkyl：CN、COOR17、CONR17R18、NR17R18、R19、OCH2CN、OCH2COOR16、OCH2CONR17R18、OCH2CF3、C3-C6Cycloalkyl oxy, C3-C6Cycloalkenyl oxy, C3-C6Non-aromatic heterocyclylalkyl epoxide, C3-C6Nonaromatic heterocycles alkenyl epoxide, C3-C6Cycloalkylsulfanyl, C3-C6Cycloalkenyl group sulfenyl, C3-C6Non-aromatic heterocyclylalkyl sulfenyl, C3-C6Nonaromatic heterocycles enylsulfanyl.Described nonaromatic heterocycles base is selected from tetrahydrofuran, thiophane, nafoxidine, tetrahydro-thiazoles, tetrahydro-pyrazole, imidazolidine, tetrahydrochysene triazole, hexahydropyridine or hexahydro pyrans；
R16Selected from C1-C4Alkyl, C1-C4Haloalkyl, C2-C4Alkenyl, C2-C4Haloalkenyl group, C2-C4Alkynyl, C2-C4Halo alkynyl or C3-C6- cycloalkyl；
R17、R18It is independently selected from hydrogen or R16；
R19Selected from following groups：P1、P2、P3、P5、P7、P8、P9、P12、P13、P14、P15、P16、P17、P19、P20、P21、P22、P23、P24、P25、P26、P27Or P28；
X is selected from O, S or NR17；
N is 0-2 integer.
The further preferred compound of the present invention is：In logical formula (I)
R1Selected from R6Or R7；
R2Selected from R8Or R9；
R3、R4、R5It is independently selected from CN, halogen or R17；
R6Selected from unsubstituted or substituted phenyl, described substituent is selected from 1-5 following radicals：Halogen, C1-C4Alkyl, C1-C4Haloalkyl, NO2Or SOnR9；
R7Selected from unsubstituted or substituted fragrant heterocyclic radical, described substituent is selected from 1-3 following radicals：Halogen, C1-C4Alkyl, C1-C4Haloalkyl, NO2、SOnR9, described fragrant heterocyclic radical is selected from pyridine radicals, pyrimidine radicals, pyridazinyl, pyrazinyl, triazine radical, thienyl, thiazolyl, thiadiazolyl group, oxazolyl, isoxazolyls, furyl, pyrrole radicals, pyrazolyl, imidazole radicals, triazolyl or Isosorbide-5-Nitrae-oxygen thiapyran；
R8Selected from R6、R7、R10、R11、R12Or R13；
R9Selected from CHR14R15；
R10Selected from the R replaced with following groups16：R6Or R7；
R11Selected from the R replaced with following groups16：XR6Or XR7；
R12Selected from the R replaced with following groups16：COOR6、COOR7、CONR6R12、CONR7R17、SO2NR6R17、SO2NR7R17、NHSO2R6Or NHSO2R7；
R13It is selected from：
R14Selected from CN or R17；
R15Selected from CN, COOR17、CONR17R18、CH2CH2OCH3, nonaromatic heterocycles base or the C replaced by following groups1-C4Alkyl：CN、COOR17、CONR17R18、NR17R18、R19、OCH2CN、OCH2COOR16、OCH2CONR17R18、OCH2CF3、C3-C6Cycloalkyl oxy, C3-C6Cycloalkenyl oxy, C3-C6Non-aromatic heterocyclylalkyl epoxide, C3-C6Nonaromatic heterocycles alkenyl epoxide, C3-C6Cycloalkylsulfanyl, C3-C6Cycloalkenyl group sulfenyl, C3-C6Non-aromatic heterocyclylalkyl sulfenyl, C3-C6Nonaromatic heterocycles enylsulfanyl；Described nonaromatic heterocycles base is selected from tetrahydrofuran, thiophane, nafoxidine, tetrahydro-thiazoles, tetrahydro-pyrazole, imidazolidine, tetrahydrochysene triazole, hexahydropyridine or hexahydro pyrans.
R16Selected from C1-C4Alkyl；
R17、R18It is independently selected from hydrogen or C1-C4Alkyl；
R19Selected from following groups：P1、P2、P3、P5、P7、P8、P9、P12、P13、P14、P15、P16、P17、P19、P20、P21、P22、P23、P24、P25、P26、P27Or P28；
X is selected from O, S or NR17；
N is 0-2 integer.
Present invention compound still further preferably is：In logical formula (I)
R1Selected from R6Or R7；
R2Selected from R8Or R9；
R3、R4、R5It is independently selected from CN, halogen or R17；
R6Selected from unsubstituted or substituted phenyl, described substituent is selected from 1-5 following radicals：Halogen, C1-C4Alkyl, C1-C4Haloalkyl；
R7Selected from unsubstituted or substituted fragrant heterocyclic radical, described substituent is selected from 1-3 following radicals：Halogen, C1-C4Alkyl, C1-C4Haloalkyl, described fragrant heterocyclic radical is selected from pyridine radicals, pyrimidine radicals, pyridazinyl, pyrazinyl, triazine radical, thienyl, thiazolyl, thiadiazolyl group, oxazolyl, isoxazolyls, furyl, pyrrole radicals, pyrazolyl, imidazole radicals, triazolyl or Isosorbide-5-Nitrae-oxygen thiapyran；
R8Selected from R6、R7、R10、R11、R12Or R13；
R9Selected from CHR14R15；
R10Selected from the R replaced with following groups16：R6Or R7；
R11Selected from the R replaced with following groups16：XR6Or XR7；
R12Selected from the R replaced with following groups16：COOR6、COOR7、CONR6R12、CONR7R17、SO2NR6R17、SO2NR7R17、NHSO2R6Or NHSO2R7；
R13It is selected from：
R14Selected from CN or R17；
R15Selected from CN, COOR17、CONR17R18、CH2CH2OCH3, nonaromatic heterocycles base, or the C replaced by following groups1-C4Alkyl：CN、COOR17、CONR17R18、NR17R18、R19、OCH2CN、OCH2COOR16、OCH2CONR17R18、OCH2CF3、C3-C6Cycloalkyl oxy, C3-C6Cycloalkenyl oxy, C3-C6Non-aromatic heterocyclylalkyl epoxide, C3-C6Nonaromatic heterocycles alkenyl epoxide.Described nonaromatic heterocycles are selected from tetrahydrofuran, thiophane, nafoxidine, tetrahydro-thiazoles, tetrahydro-pyrazole, imidazolidine, tetrahydrochysene triazole, hexahydropyridine or hexahydro pyrans
R16Selected from C1-C4Alkyl；
R17、R18It is independently selected from hydrogen or C1-C4Alkyl；
R19Selected from following groups：P1、P2、P3、P5、P7、P8、P12、P14、P17、P19、P20、P21、P22、P23、P24、P25、P26、P27Or P28；
X is selected from O, S or NR17；
N is 0-2 integer.
Present invention compound still more preferably is：In logical formula (I)
R1Selected from R6；
R2Selected from R8Or R9；
R3、R4、R5It is independently selected from CN, halogen or R17；
R6Selected from unsubstituted or substituted phenyl, described substituent is selected from 1-5 following radicals：Halogen, C1-C4Alkyl, C1-C4Haloalkyl；
R7Selected from unsubstituted or substituted fragrant heterocyclic radical, described substituent is selected from 1-3 following radicals：Halogen, C1-C4Alkyl, C1-C4Haloalkyl, described fragrant heterocyclic radical is selected from pyridine radicals, pyrimidine radicals, pyridazinyl, pyrazinyl, triazine radical, thienyl, thiazolyl, thiadiazolyl group, oxazolyl, isoxazolyls, furyl, pyrrole radicals, pyrazolyl, imidazole radicals, triazolyl or Isosorbide-5-Nitrae-oxygen thiapyran；
R8Selected from R6、R7、R10、R11、R12Or R13；
R9Selected from CHR14R15；
R10Selected from the R replaced with following groups16：R6Or R7；
R11Selected from the R replaced with following groups16：XR6Or XR7；
R12Selected from the R replaced with following groups16：COOR6、COOR7、CONR6R12、CONR7R17、SO2NR6R17、SO2NR7R17、NHSO2R6Or NHSO2R7；
R13It is selected from：
R14Selected from CN or R17；
R15Selected from CN, CH2CH2OCH3, nonaromatic heterocycles base or the C replaced by following groups1-C4Alkyl：CN、NR17R18、OCH2CN、OCH2CF3、C3-C6Cycloalkyl oxy, C3-C6Cycloalkenyl oxy, C3-C6Non-aromatic heterocyclylalkyl epoxide, C3-C6Nonaromatic heterocycles alkenyl epoxide；Described nonaromatic heterocycles base is selected from tetrahydrofuran, thiophane, nafoxidine, tetrahydro-thiazoles, tetrahydro-pyrazole, imidazolidine, tetrahydrochysene triazole, hexahydropyridine or hexahydro pyrans；
R16Selected from C1-C4Alkyl；
R17、R18It is independently selected from hydrogen or C1-C4Alkyl；
X is selected from O.
Substituent described in the logical formula (I) compound of the present invention has following implications：
Halogen represents fluorine, chlorine, bromine or iodine.
The term " halo " above occurred in group represents that the group is part or all of halo, that is to say, that mode in any combination is replaced by F, Cl, Br or I, is preferably replaced by F or Cl.
Alkyl and its part (unless otherwise indicated) can be straight or brancheds.
Expression formula " C1-C6Alkyl " can be understood as representing the straight or branched alkyl with 1 to 6 carbon atoms, e.g., such as methyl, ethyl, propyl group, isopropyl, 1- butyl, 2- butyl, 2- methyl-propyls or the tert-butyl group.
Alkyl in alkyl and combination group, unless otherwise indicated, preferably with 1-4 carbon atom.
“C1-C6Haloalkyl " means expression formula " C1-C6Alkyl described in alkyl ", wherein one or more hydrogen atoms are replaced by same amount of identical or different halogen atoms, such as a haloalkyl, whole haloalkyl, CF3、CHF2、CHxF、CHFCH3、CF3CF2、CHF2CF2、CH2FCHCl、CH2Cl、CCl3、CHCl2Or CH2CH2Cl。
“C1-C6Alkoxy " means that the carbochain in alkoxy has in expression formula " C1-C6Alkyl " represents the straight or branched alkyl with 1 to 6 carbon atoms, such as methyl, ethyl, propyl group, isopropyl, 1- butyl, 2- butyl, 2- methyl-propyls or the tert-butyl group.
“C2-C6Alkenyl " represents the double bond that the non-cyclic carbon chain and the carbochain of the straight or branched with carbon number corresponding with the scope contain at least one optional position that can be positioned at respective unsaturated group.Therefore " C2-C12Alkenyl " is represented such as vinyl, pi-allyl, 2- methyl -2- acrylic, 2- cyclobutenyls, pentenyl, 2- methylpents alkenyl or hexenyl.
“C2-C6Alkynyl " represents three keys that the non-cyclic carbon chain and the carbochain of the straight or branched with carbon number corresponding with the scope contain an optional position that can be positioned at respective unsaturated group.Therefore " C2-C6Alkynyl " is represented such as propargyl, 1- methyl -2-propynyl, 2- butynyls or 3- butynyls.
There is 3-7 carbon atom in the preferred ring of cycloalkyl and optionally replaced by halogen or alkyl.
It is prepared by the method that the logical formula (I) compound of the present invention may be referred to provide in the documents such as patent US200320808, JP2003286265.
The compound that the logical formula (I) compound of the present invention includes but is not limited in following compound list 1 and 2.
(the wherein R of compound list 12For R8)
| Numbering | R1 | R8 | R3 | R4 | R5 |
| I-1 | 4- chlorphenyls | Ph | H | H | But |
| I-2 | 2- trifluoromethyls | Ph | H | H | But |
| I-3 | 3- (4- trifluoromethyl pyridines base) | Ph | H | H | But |
| I-4 | 5- (1- methyl -3- ethyl pyrazolyls) | Ph | H | H | But |
| I-5 | 4- chlorphenyls | Q1 | H | H | But |
| I-6 | 2- trifluoromethyls | Q1 | H | H | But |
| I-7 | 3- (4- trifluoromethyl pyridines base) | Q1 | H | H | But |
| I-8 | 5- (1- methyl -3- ethyl pyrazolyls) | Q1 | H | H | But |
| I-9 | 4- chlorphenyls | Q2 | H | H | But |
| I-10 | 2- trifluoromethyls | Q2 | H | H | But |
| I-11 | 3- (4- trifluoromethyl pyridines base) | Q2 | H | H | But |
| I-12 | 5- (1- methyl -3- ethyl pyrazolyls) | Q2 | H | H | But |
| I-13 | 4- chlorphenyls | Q3 | H | H | But |
| I-14 | 2- trifluoromethyls | Q3 | H | H | But |
| I-15 | 3- (4- trifluoromethyl pyridines base) | Q3 | H | H | But |
| I-16 | 5- (1- methyl -3- ethyl pyrazolyls) | Q3 | H | H | But |
| I-17 | 4- chlorphenyls | Q4 | H | H | But |
| I-18 | 2- trifluoromethyls | Q4 | H | H | But |
| I-19 | 3- (4- trifluoromethyl pyridines base) | Q4 | H | H | But |
| I-20 | 5- (1- methyl -3- ethyl pyrazolyls) | Q4 | H | H | But |
| I-21 | 2- trifluoromethyls | Q5 | H | H | But |
| I-22 | 2- trifluoromethyls | Q6 | H | H | But |
| I-23 | 2,6- difluorophenyls | CH2CH2Ph | H | H | But |
| I-24 | 4- chlorphenyls | CH2CH2Ph | H | H | But |
| I-25 | 2- trifluoromethyls | CH2CH2Ph | H | H | But |
| I-26 | 1- (4- chlorphenyls)-isobutyl group | CH2CH2Ph | H | H | But |
| I-27 | 3- (4- trifluoromethyl pyridines base) | CH2CH2Ph | H | H | But |
| I-28 | 3- (6- chloropyridines base) | CH2CH2Ph | H | H | But |
| I-29 | 2- (6- (3- trifluoromethyls) pyridine radicals) | CH2CH2Ph | H | H | But |
| I-30 | 5- (4- trifluoromethyl pyrimidines base) | CH2CH2Ph | H | H | But |
| I-31 | 4- (2- diurils oxazolyl) | CH2CH2Ph | H | H | But |
| I-32 | 5- (4- trifluoromethyl thiazoles base) | CH2CH2Ph | H | H | But |
| I-33 | 5- (2- methyl -4- trifluoromethyl thiazoles base) | CH2CH2Ph | H | H | But |
| I-34 | 5- (the chloro- 4- trifluoromethyl thiazoles bases of 2-) | CH2CH2Ph | H | H | But |
| I-35 | 5- (1- methyl-3-trifluoromethyl pyrazols base) | CH2CH2Ph | H | H | But |
| I-36 | 5- (1- methyl -3- ethyl pyrazolyls) | CH2CH2Ph | H | H | But |
| I-37 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | CH2CH2Ph | H | H | But |
| I-38 | 5- (1- (2- (3- chloropyridines base)) -3- bromines pyrazolyl) | CH2CH2Ph | H | H | But |
| I-39 | 3- (2,2- dichloroethylene) -2,2- dimethylcyclopropane bases | CH2CH2Ph | H | H | But |
| I-40 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | CH2CH2Ph | H | H | But |
| I-41 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | CH2CH2Ph | H | H | But |
| I-42 | 2- trifluoromethyls | Q7 | H | H | But |
| I-43 | 2- trifluoromethyls | Q8 | H | H | But |
| I-44 | 2- trifluoromethyls | Q9 | H | H | But |
| I-45 | 2,6- difluorophenyls | (CH2)3Ph | H | H | But |
| I-46 | 4- chlorphenyls | (CH2)3Ph | H | H | But |
| I-47 | 2- trifluoromethyls | (CH2)3Ph | H | H | But |
| I-48 | 1- (4- chlorphenyls)-isobutyl group | (CH2)3Ph | H | H | But |
| I-49 | 3- (4- trifluoromethyl pyridines base) | (CH2)3Ph | H | H | But |
| I-50 | 3- (6- chloropyridines base) | (CH2)3Ph | H | H | But |
| I-51 | 2- (6- (3- trifluoromethyls) pyridine radicals) | (CH2)3Ph | H | H | But |
| I-52 | 5- (4- trifluoromethyl pyrimidines base) | (CH2)3Ph | H | H | But |
| I-53 | 4- (2- diurils oxazolyl) | (CH2)3Ph | H | H | But |
| I-54 | 5- (4- trifluoromethyl thiazoles base) | (CH2)3Ph | H | H | But |
| I-55 | 5- (2- methyl -4- trifluoromethyl thiazoles base) | (CH2)3Ph | H | H | But |
| I-56 | 5- (the chloro- 4- trifluoromethyl thiazoles bases of 2-) | (CH2)3Ph | H | H | But |
| I-57 | 5- (1- methyl-3-trifluoromethyl pyrazols base) | (CH2)3Ph | H | H | But |
| I-58 | 5- (1- methyl -3- ethyl pyrazolyls) | (CH2)3Ph | H | H | But |
| I-59 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | (CH2)3Ph | H | H | But |
| I-60 | 5- (1- (2- (3- chloropyridines base)) -3- bromines pyrazolyl) | (CH2)3Ph | H | H | But |
| I-61 | 3- (2,2- dichloroethylene) -2,2- dimethylcyclopropane bases | (CH2)3Ph | H | H | But |
| I-62 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | (CH2)3Ph | H | H | But |
| I-63 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | (CH2)3Ph | H | H | But |
| I-64 | 4- chlorphenyls | (CH2)4Ph | H | H | But |
| I-65 | 2- trifluoromethyls | (CH2)4Ph | H | H | But |
| I-66 | 3- (4- trifluoromethyl pyridines base) | (CH2)4Ph | H | H | But |
| I-67 | 5- (1- methyl -3- ethyl pyrazolyls) | (CH2)4Ph | H | H | But |
| I-68 | 2- trifluoromethyls | Q10 | H | H | But |
| I-69 | 2- trifluoromethyls | Q11 | H | H | But |
| I-70 | 2- trifluoromethyls | Q12 | H | H | But |
| I-71 | 4- chlorphenyls | Q13 | H | H | But |
| I-72 | 2- trifluoromethyls | Q13 | H | H | But |
| I-73 | 3- (4- trifluoromethyl pyridines base) | Q13 | H | H | But |
| I-74 | 5- (1- methyl -3- ethyl pyrazolyls) | Q13 | H | H | But |
| I-75 | 2,6- difluorophenyls | Q14 | H | H | But |
| I-76 | 4- chlorphenyls | Q14 | H | H | But |
| I-77 | 2- trifluoromethyls | Q14 | H | H | But |
| I-78 | 1- (4- chlorphenyls)-isobutyl group | Q14 | H | H | But |
| I-79 | 3- (4- trifluoromethyl pyridines base) | Q14 | H | H | But |
| I-80 | 3- (6- chloropyridines base) | Q14 | H | H | But |
| I-81 | 2- (6- (3- trifluoromethyls) pyridine radicals) | Q14 | H | H | But |
| I-82 | 5- (4- trifluoromethyl pyrimidines base) | Q14 | H | H | But |
| I-83 | 4- (2- diurils oxazolyl) | Q14 | H | H | But |
| I-84 | 5- (4- trifluoromethyl thiazoles base) | Q14 | H | H | But |
| I-85 | 5- (2- methyl -4- trifluoromethyl thiazoles base) | Q14 | H | H | But |
| I-86 | 5- (the chloro- 4- trifluoromethyl thiazoles bases of 2-) | Q14 | H | H | But |
| I-87 | 5- (1- methyl-3-trifluoromethyl pyrazols base) | Q14 | H | H | But |
| I-88 | 5- (1- methyl -3- ethyl pyrazolyls) | Q14 | H | H | But |
| I-89 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | Q14 | H | H | But |
| I-90 | 5- (1- (2- (3- chloropyridines base)) -3- bromines pyrazolyl) | Q14 | H | H | But |
| I-91 | 3- (2,2- dichloroethylene) -2,2- dimethylcyclopropane bases | Q14 | H | H | But |
| I-92 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | Q14 | H | H | But |
| I-93 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | Q14 | H | H | But |
| I-94 | 4- chlorphenyls | Q15 | H | H | But |
| I-95 | 2- trifluoromethyls | Q15 | H | H | But |
| I-96 | 3- (4- trifluoromethyl pyridines base) | Q15 | H | H | But |
| I-97 | 5- (1- methyl -3- ethyl pyrazolyls) | Q15 | H | H | But |
| I-98 | 2,6- difluorophenyls | Q16 | H | H | But |
| I-99 | 4- chlorphenyls | Q16 | H | H | Buw |
| I-100 | 2- trifluoromethyls | Q16 | H | H | But |
| I-101 | 1- (4- chlorphenyls)-isobutyl group | Q16 | H | H | But |
| I-102 | 3- (4- trifluoromethyl pyridines base) | Q16 | H | H | But |
| I-103 | 3- (6- chloropyridines base) | Q16 | H | H | But |
| I-104 | 2- (6- (3- trifluoromethyls) pyridine radicals) | Q16 | H | H | But |
| I-105 | 5- (4- trifluoromethyl pyrimidines base) | Q16 | H | H | But |
| I-106 | 4- (2- diurils oxazolyl) | Q16 | H | H | But |
| I-107 | 5- (4- trifluoromethyl thiazoles base) | Q16 | H | H | But |
| I-108 | 5- (2- methyl -4- trifluoromethyl thiazoles base) | Q16 | H | H | But |
| I-109 | 5- (the chloro- 4- trifluoromethyl thiazoles bases of 2-) | Q16 | H | H | But |
| I-110 | 5- (1- methyl-3-trifluoromethyl pyrazols base) | Q16 | H | H | But |
| I-111 | 5- (1- methyl -3- ethyl pyrazolyls) | Q16 | H | H | But |
| I-112 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | Q16 | H | H | But |
| I-113 | 5- (1- (2- (3- chloropyridines base)) -3- bromines pyrazolyl) | Q16 | H | H | But |
| I-114 | 3- (2,2- dichloroethylene) -2,2- dimethylcyclopropane bases | Q16 | H | H | But |
| I-115 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | Q16 | H | H | But |
| I-116 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | Q16 | H | H | But |
| I-117 | 2,6- difluorophenyls | Q17 | H | H | But |
| I-118 | 4- chlorphenyls | Q17 | H | H | But |
| I-119 | 2- trifluoromethyls | Q17 | H | H | But |
| I-120 | 1- (4- chlorphenyls)-isobutyl group | Q17 | H | H | But |
| I-121 | 3- (4- trifluoromethyl pyridines base) | Q17 | H | H | But |
| I-122 | 3- (6- chloropyridines base) | Q17 | H | H | But |
| I-123 | 2- (6- (3- trifluoromethyls) pyridine radicals) | Q17 | H | H | But |
| I-124 | 5- (4- trifluoromethyl pyrimidines base) | Q17 | H | H | But |
| I-125 | 4- (2- diurils oxazolyl) | Q17 | H | H | But |
| I-126 | 5- (4- trifluoromethyl thiazoles base) | Q17 | H | H | But |
| I-127 | 5- (2- methyl -4- trifluoromethyl thiazoles base) | Q17 | H | H | But |
| I-128 | 5- (the chloro- 4- trifluoromethyl thiazoles bases of 2-) | Q17 | H | H | But |
| I-129 | 5- (1- methyl-3-trifluoromethyl pyrazols base) | Q17 | H | H | But |
| I-130 | 5- (1- methyl -3- ethyl pyrazolyls) | Q17 | H | H | But |
| I-131 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | Q17 | H | H | But |
| I-132 | 5- (1- (2- (3- chloropyridines base)) -3- bromines pyrazolyl) | Q17 | H | H | But |
| I-133 | 3- (2,2- dichloroethylene) -2,2- dimethylcyclopropane bases | Q17 | H | H | But |
| I-134 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | Q17 | H | H | But |
| I-135 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | Q17 | H | H | But |
| I-136 | 2,6- difluorophenyls | Q18 | H | H | But |
| I-137 | 4- chlorphenyls | Q18 | H | H | But |
| I-138 | 2- trifluoromethyls | Q18 | H | H | But |
| I-139 | 1- (4- chlorphenyls)-isobutyl group | Q18 | H | H | But |
| I-140 | 3- (4- trifluoromethyl pyridines base) | Q18 | H | H | But |
| I-141 | 3- (6- chloropyridines base) | Q18 | H | H | But |
| I-142 | 2- (6- (3- trifluoromethyls) pyridine radicals) | Q18 | H | H | But |
| I-143 | 5- (4- trifluoromethyl pyrimidines base) | Q18 | H | H | But |
| I-144 | 4- (2- diurils oxazolyl) | Q18 | H | H | But |
| I-145 | 5- (4- trifluoromethyl thiazoles base) | Q18 | H | H | But |
| I-146 | 5- (2- methyl -4- trifluoromethyl thiazoles base) | Q18 | H | H | But |
| I-147 | 5- (the chloro- 4- trifluoromethyl thiazoles bases of 2-) | Q18 | H | H | But |
| I-148 | 5- (1- methyl-3-trifluoromethyl pyrazols base) | Q18 | H | H | But |
| I-149 | 5- (1- methyl -3- ethyl pyrazolyls) | Q18 | H | H | But |
| I-150 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | Q18 | H | H | But |
| I-151 | 5- (1- (2- (3- chloropyridines base)) -3- bromines pyrazolyl) | Q18 | H | H | But |
| I-152 | 3- (2,2- dichloroethylene) -2,2- dimethylcyclopropane bases | Q18 | H | H | But |
| I-153 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles | Q18 | H | H | But |
| I-154 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | Q18 | H | H | But |
| I-155 | 4- chlorphenyls | Q19 | H | H | But |
| I-156 | 2- trifluoromethyls | Q19 | H | H | But |
| I-157 | 3- (4- trifluoromethyl pyridines base) | Q19 | H | H | But |
| I-158 | 5- (1- methyl -3- ethyl pyrazolyls) | Q19 | H | H | But |
| I-159 | 4- chlorphenyls | Q20 | H | H | But |
| I-160 | 2- trifluoromethyls | Q20 | H | H | But |
| I-161 | 3- (4- trifluoromethyl pyridines base) | Q20 | H | H | But |
| I-162 | 5- (1- methyl -3- ethyl pyrazolyls) | Q20 | H | H | But |
| I-163 | 4- chlorphenyls | Q21 | H | H | But |
| I-164 | 2- trifluoromethyls | Q21 | H | H | But |
| I-165 | 3- (4- trifluoromethyl pyridines base) | Q21 | H | H | But |
| I-166 | 5- (1- methyl -3- ethyl pyrazolyls) | Q21 | H | H | But |
| I-167 | 2,6- difluorophenyls | Q22 | H | H | But |
| I-168 | 4- chlorphenyls | Q22 | H | H | But |
| I-169 | 2- trifluoromethyls | Q22 | H | H | But |
| I-170 | 1- (4- chlorphenyls)-isobutyl group | Q22 | H | H | But |
| I-171 | 3- (4- trifluoromethyl pyridines base) | Q23 | H | H | But |
| I-172 | 3- (6- chloropyridines base) | Q23 | H | H | But |
| I-173 | 2- (6- (3- trifluoromethyls) pyridine radicals) | Q23 | H | H | But |
| I-174 | 5- (4- trifluoromethyl pyrimidines base) | Q23 | H | H | But |
| I-175 | 4- (2- diurils oxazolyl) | Q23 | H | H | But |
| I-176 | 5- (4- trifluoromethyl thiazoles base) | Q23 | H | H | But |
| I-177 | 5- (2- methyl -4- trifluoromethyl thiazoles base) | Q23 | H | H | But |
| I-178 | 5- (the chloro- 4- trifluoromethyl thiazoles bases of 2-) | Q23 | H | H | But |
| I-179 | 5- (1- methyl-3-trifluoromethyl pyrazols base) | Q23 | H | H | But |
| I-180 | 5- (1- methyl -3- ethyl pyrazolyls) | Q23 | H | H | But |
| I-181 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | Q23 | H | H | But |
| I-182 | 5- (1- (2- (3- chloropyridines base)) -3- bromines pyrazolyl) | Q23 | H | H | But |
| I-183 | 3- (2,2- dichloroethylene) -2,2- dimethylcyclopropane bases | Q23 | H | H | But |
| I-184 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | Q23 | H | H | But |
| I-185 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | Q23 | H | H | But |
| I-186 | 4- chlorphenyls | Q24 | H | H | But |
| I-187 | 2- trifluoromethyls | Q24 | H | H | But |
| I-188 | 3- (4- trifluoromethyl pyridines base) | Q24 | H | H | But |
| I-189 | 5- (1- methyl -3- ethyl pyrazolyls) | Q24 | H | H | But |
| I-190 | 4- chlorphenyls | Q25 | H | H | But |
| I-191 | 2- trifluoromethyls | Q25 | H | H | But |
| I-192 | 3- (4- trifluoromethyl pyridines base) | Q25 | H | H | But |
| I-193 | 5- (1- methyl -3- ethyl pyrazolyls) | Q25 | H | H | But |
| I-194 | 4- chlorphenyls | Q26 | H | H | But |
| I-195 | 2- trifluoromethyls | Q26 | H | H | But |
| I-196 | 3- (4- trifluoromethyl pyridines base) | Q26 | H | H | But |
| I-197 | 5- (1- methyl -3- ethyl pyrazolyls) | Q26 | H | H | But |
| I-198 | 2,6- difluorophenyls | CH2CH2OPh | H | H | But |
| I-199 | 4- chlorphenyls | CH2CH2OPh | H | H | But |
| I-200 | 2- trifluoromethyls | CH2CH2OPh | H | H | But |
| I-201 | 1- (4- chlorphenyls)-isobutyl group | CH2CH2OPh | H | H | But |
| I-202 | 3- (4- trifluoromethyl pyridines base) | CH2CH2OPh | H | H | But |
| I-203 | 3- (6- chloropyridines base) | CH2CH2OPh | H | H | But |
| I-204 | 2- (6- (3- trifluoromethyls) pyridine radicals) | CH2CH2OPh | H | H | But |
| I-205 | 5- (4- trifluoromethyl pyrimidines base) | CH2CH2OPh | H | H | But |
| I-206 | 4- (2- diurils oxazolyl) | CH2CH2OPh | H | H | But |
| I-207 | 5- (4- trifluoromethyl thiazoles base) | CH2CH2OPh | H | H | But |
| I-208 | 5- (2- methyl -4- trifluoromethyl thiazoles base) | CH2CH2OPh | H | H | But |
| I-209 | 5- (the chloro- 4- trifluoromethyl thiazoles bases of 2-) | CH2CH2OPh | H | H | But |
| I-210 | 5- (1- methyl-3-trifluoromethyl pyrazols base) | CH2CH2OPh | H | H | But |
| I-211 | 5- (1- methyl -3- ethyl pyrazolyls) | CH2CH2OPh | H | H | But |
| I-212 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | CH2CH2OPh | H | H | But |
| I-213 | 5- (1- (2- (3- chloropyridines base)) -3- bromines pyrazolyl) | CH2CH2OPh | H | H | But |
| I-214 | 3- (2,2- dichloroethylene) -2,2- dimethylcyclopropane bases | CH2CH2OPh | H | H | But |
| I-215 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles | CH2CH2OPh | H | H | But |
| I-216 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | CH2CH2OPh | H | H | But |
| I-217 | 2- trifluoromethyls | Q27 | H | H | But |
| I-218 | 2- trifluoromethyls | Q28 | H | H | But |
| I-219 | 2- trifluoromethyls | Q29 | H | H | But |
| I-220 | 2- trifluoromethyls | Q30 | H | H | But |
| I-221 | 2- trifluoromethyls | Q31 | H | H | But |
| I-222 | 2- trifluoromethyls | Q32 | H | H | But |
| I-223 | 2- trifluoromethyls | Q33 | H | H | But |
| I-224 | 2- trifluoromethyls | Q34 | H | H | But |
| I-225 | 2- trifluoromethyls | Q35 | H | H | But |
| I-226 | 2- trifluoromethyls | Q36 | H | H | But |
| I-227 | 2- trifluoromethyls | Q37 | H | H | But |
| I-228 | 2- trifluoromethyls | Q38 | H | H | But |
| I-229 | 2- trifluoromethyls | Q39 | H | H | But |
| I-230 | 2- trifluoromethyls | Q40 | H | H | But |
| I-231 | 2- trifluoromethyls | Q41 | H | H | But |
| I-232 | 2- trifluoromethyls | Q42 | H | H | But |
| I-233 | 4- chlorphenyls | (CH2)3OPh | H | H | But |
| I-234 | 2- trifluoromethyls | (CH2)3OPh | H | H | But |
| I-235 | 3- (4- trifluoromethyl pyridines base) | (CH2)3OPh | H | H | But |
| I-236 | 5- (1- methyl -3- ethyl pyrazolyls) | (CH2)3OPh | H | H | But |
| I-237 | 2- trifluoromethyls | Q43 | H | H | But |
| I-238 | 2- trifluoromethyls | Q44 | H | H | But |
| I-239 | 2- trifluoromethyls | Q45 | H | H | But |
| I-240 | 2- trifluoromethyls | Q46 | H | H | But |
| I-241 | 2,6- difluorophenyls | Q47 | H | H | But |
| I-242 | 4- chlorphenyls | Q47 | H | H | But |
| I-243 | 2- trifluoromethyls | Q47 | H | H | But |
| I-244 | 1- (4- chlorphenyls)-isobutyl group | Q47 | H | H | But |
| I-245 | 3- (4- trifluoromethyl pyridines base) | Q47 | H | H | But |
| I-246 | 3- (6- chloropyridines base) | Q47 | H | H | But |
| I-247 | 2- (6- (3- trifluoromethyls) pyridine radicals) | Q47 | H | H | But |
| I-248 | 5- (4- trifluoromethyl pyrimidines base) | Q47 | H | H | But |
| I-249 | 4- (2- diurils oxazolyl) | Q47 | H | H | But |
| I-250 | 5- (4- trifluoromethyl thiazoles base) | Q47 | H | H | But |
| I-251 | 5- (2- methyl -4- trifluoromethyl thiazoles base) | Q47 | H | H | But |
| I-252 | 5- (the chloro- 4- trifluoromethyl thiazoles bases of 2-) | Q47 | H | H | But |
| I-253 | 5- (1- methyl-3-trifluoromethyl pyrazols base) | Q47 | H | H | But |
| I-254 | 5- (1- methyl -3- ethyl pyrazolyls) | Q47 | H | H | But |
| I-255 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | Q47 | H | H | But |
| I-256 | 5- (1- (2- (3- chloropyridines base)) -3- bromines pyrazolyl) | Q47 | H | H | But |
| I-257 | 3- (2,2- dichloroethylene) -2,2- dimethylcyclopropane bases | Q47 | H | H | But |
| I-258 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | Q47 | H | H | But |
| I-259 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | Q47 | H | H | But |
| I-260 | 4- chlorphenyls | Q48 | H | H | But |
| I-261 | 2- trifluoromethyls | Q48 | H | H | But |
| I-262 | 3- (4- trifluoromethyl pyridines base) | Q48 | H | H | But |
| I-263 | 5- (1- methyl -3- ethyl pyrazolyls) | Q48 | H | H | But |
| I-264 | 2,6- difluorophenyls | Q49 | H | H | But |
| I-265 | 4- chlorphenyls | Q49 | H | H | But |
| I-266 | 2- trifluoromethyls | Q49 | H | H | But |
| I-267 | 1- (4- chlorphenyls)-isobutyl group | Q49 | H | H | But |
| I-268 | 3- (4- trifluoromethyl pyridines base) | Q49 | H | H | But |
| I-269 | 3- (6- chloropyridines base) | Q49 | H | H | But |
| I-270 | 2- (6- (3- trifluoromethyls) pyridine radicals) | Q49 | H | H | But |
| I-271 | 5- (4- trifluoromethyl pyrimidines base) | Q49 | H | H | But |
| I-272 | 4- (2- diurils oxazolyl) | Q49 | H | H | But |
| I-273 | 5- (4- trifluoromethyl thiazoles base) | Q49 | H | H | But |
| I-274 | 5- (2- methyl -4- trifluoromethyl thiazoles base) | Q49 | H | H | But |
| I-275 | 5- (the chloro- 4- trifluoromethyl thiazoles bases of 2-) | Q49 | H | H | But |
| I-276 | 5- (1- methyl-3-trifluoromethyl pyrazols base) | Q49 | H | H | But |
| I-277 | 5- (1- methyl -3- ethyl pyrazolyls) | Q49 | H | H | But |
| I-278 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | Q49 | H | H | But |
| I-279 | 5- (1- (2- (3- chloropyridines base)) -3- bromines pyrazolyl) | Q49 | H | H | But |
| I-280 | 3- (2,2- dichloroethylene) -2,2- dimethylcyclopropane bases | Q49 | H | H | But |
| I-281 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | Q49 | H | H | But |
| I-282 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | Q49 | H | H | But |
| I-283 | 4- chlorphenyls | Q50 | H | H | But |
| I-284 | 2- trifluoromethyls | Q50 | H | H | But |
| I-285 | 2,6- difluorophenyls | Q51 | H | H | But |
| I-286 | 4- chlorphenyls | Q51 | H | H | But |
| I-287 | 2- trifluoromethyls | Q51 | H | H | But |
| I-288 | 1- (4- chlorphenyls)-isobutyl group | Q51 | H | H | But |
| I-289 | 3- (4- trifluoromethyl pyridines base) | Q51 | H | H | But |
| I-290 | 3- (6- chloropyridines base) | Q51 | H | H | But |
| I-291 | 2- (6- (3- trifluoromethyls) pyridine radicals) | Q51 | H | H | But |
| I-292 | 5- (4- trifluoromethyl pyrimidines base) | Q51 | H | H | But |
| I-293 | 4- (2- diurils oxazolyl) | Q51 | H | H | But |
| I-294 | 5- (4- trifluoromethyl thiazoles base) | Q51 | H | H | But |
| I-295 | 5- (2- methyl -4- trifluoromethyl thiazoles base) | Q51 | H | H | But |
| I-296 | 5- (the chloro- 4- trifluoromethyl thiazoles bases of 2-) | Q51 | H | H | But |
| I-297 | 5- (1- methyl-3-trifluoromethyl pyrazols base) | Q51 | H | H | But |
| I-298 | 5- (1- methyl -3- ethyl pyrazolyls) | Q51 | H | H | But |
| I-299 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | Q51 | H | H | But |
| I-300 | 5- (1- (2- (3- chloropyridines base)) -3- bromines pyrazolyl) | Q51 | H | H | But |
| I-301 | 3- (2,2- dichloroethylene) -2,2- dimethylcyclopropane bases | Q51 | H | H | But |
| I-302 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | Q51 | H | H | But |
| I-303 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | Q51 | H | H | But |
| I-304 | 4- chlorphenyls | Q52 | H | H | But |
| I-305 | 2- trifluoromethyls | Q52 | H | H | But |
| I-306 | 3- (4- trifluoromethyl pyridines base) | Q52 | H | H | But |
| I-307 | 5- (1- methyl -3- ethyl pyrazolyls) | Q52 | H | H | But |
| I-308 | 2,6- difluorophenyls | Q52 | H | H | But |
| I-309 | 4- chlorphenyls | Q52 | H | H | But |
| I-310 | 2- trifluoromethyls | Q52 | H | H | But |
| I-311 | 1- (4- chlorphenyls)-isobutyl group | Q52 | H | H | But |
| I-312 | 3- (4- trifluoromethyl pyridines base) | Q52 | H | H | But |
| I-313 | 3- (6- chloropyridines base) | Q52 | H | H | But |
| I-314 | 2- (6- (3- trifluoromethyls) pyridine radicals) | Q52 | H | H | But |
| I-315 | 5- (4- trifluoromethyl pyrimidines base) | Q52 | H | H | But |
| I-316 | 4- (2- diurils oxazolyl) | Q52 | H | H | But |
| I-317 | 5- (4- trifluoromethyl thiazoles base) | Q52 | H | H | But |
| I-318 | 5- (the chloro- 4- trifluoromethyl thiazoles bases of 2-) | Q52 | H | H | But |
| I-319 | 5- (1- methyl -3- ethyl pyrazolyls) | Q52 | H | H | But |
| I-320 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | Q52 | H | H | But |
| I-321 | 5- (1- (2- (3- chloropyridines base)) -3- bromines pyrazolyl) | Q52 | H | H | But |
| I-322 | 3- (2,2- dichloroethylene) -2,2- dimethylcyclopropane bases | Q52 | H | H | But |
| I-323 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | Q52 | H | H | But |
| I-324 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | Q52 | H | H | But |
| I-325 | 4- chlorphenyls | Q53 | H | H | But |
| I-326 | 2- trifluoromethyls | Q53 | H | H | But |
| I-327 | 4- chlorphenyls | Q54 | H | H | But |
| I-328 | 2- trifluoromethyls | Q54 | H | H | But |
| I-329 | 4- chlorphenyls | Q55 | H | H | But |
| I-330 | 2- trifluoromethyls | Q55 | H | H | But |
| I-331 | 4- chlorphenyls | Q56 | H | H | But |
| I-332 | 2- trifluoromethyls | Q56 | H | H | But |
| I-333 | 4- chlorphenyls | Q57 | H | H | But |
| I-334 | 2- trifluoromethyls | Q57 | H | H | But |
| I-335 | 4- chlorphenyls | Q58 | H | H | But |
| I-336 | 2- trifluoromethyls | Q58 | H | H | But |
| I-337 | 4- chlorphenyls | Q59 | H | H | But |
| I-338 | 2- trifluoromethyls | Q59 | H | H | But |
| I-339 | 4- chlorphenyls | Q60 | H | H | But |
| I-340 | 2- trifluoromethyls | Q60 | H | H | But |
| I-341 | 4- chlorphenyls | Q61 | H | H | But |
| I-342 | 2- trifluoromethyls | Q61 | H | H | But |
| I-343 | 2- trifluoromethyls | Q62 | H | H | But |
| I-344 | 2- trifluoromethyls | Q63 | H | H | But |
| I-345 | 2- trifluoromethyls | Q64 | H | H | But |
| I-346 | 2- trifluoromethyls | Q65 | H | H | But |
| I-347 | 2- trifluoromethyls | Q66 | H | H | But |
| I-348 | 2- trifluoromethyls | Q67 | H | H | But |
| I-349 | 2- trifluoromethyls | Q68 | H | H | But |
| I-350 | 2- trifluoromethyls | Q69 | H | H | But |
| I-351 | 2- trifluoromethyls | Q70 | H | H | But |
| I-352 | 2- trifluoromethyls | Q71 | H | H | But |
| I-353 | 2- trifluoromethyls | Q72 | H | H | But |
| I-354 | 2- trifluoromethyls | Q73 | H | H | But |
| I-355 | 2- trifluoromethyls | Q74 | H | H | But |
| I-356 | 2- trifluoromethyls | Q75 | H | H | But |
| I-357 | 2- trifluoromethyls | Q76 | H | H | But |
| I-358 | 2- trifluoromethyls | Q77 | H | H | But |
| I-359 | 2- trifluoromethyls | Q78 | H | H | But |
| I-360 | 2- trifluoromethyls | Q79 | H | H | But |
| I-361 | 2- trifluoromethyls | Q80 | H | H | But |
| I-362 | 2- trifluoromethyls | Q81 | H | H | But |
| I-363 | 2- trifluoromethyls | Q82 | H | H | But |
| I-364 | 2- trifluoromethyls | Q83 | H | H | But |
| I-365 | 2- trifluoromethyls | Q84 | H | H | But |
| I-366 | 2- trifluoromethyls | Q85 | H | H | But |
| I-367 | 2- trifluoromethyls | Q86 | H | H | But |
| I-368 | 2- trifluoromethyls | Q87 | H | H | But |
| I-369 | 2- trifluoromethyls | CH2CH2Ph | H | H | Cl |
| I-370 | 2- trifluoromethyls | CH2CH2Ph | H | H | CH3 |
| I-371 | 2- trifluoromethyls | CH2CH2Ph | H | H | Ph |
| I-372 | 2- trifluoromethyls | CH2CH2Ph | Cl | H | But |
| I-373 | 2- trifluoromethyls | CH2CH2OPh | H | H | Cl |
| I-374 | 2- trifluoromethyls | CH2CH2OPh | H | H | CH3 |
| I-375 | 2- trifluoromethyls | CH2CH2OPh | H | H | Ph |
| I-376 | 2- trifluoromethyls | CH2CH2OPh | Cl | H | But |
| I-377 | 2- trifluoromethyls | (CH2CH2)3Ph | Cl | H | But |
| I-378 | 2- trifluoromethyls | Q88 | H | H | But |
| I-379 | 2- trifluoromethyls | Q89 | H | H | But |
| I-380 | 2- trifluoromethyls | Q90 | H | H | But |
| I-381 | 2- trifluoromethyls | Q91 | H | H | But |
| I-382 | 2- trifluoromethyls | Q92 | H | H | But |
| I-383 | 2- trifluoromethyls | Q93 | H | H | But |
| I-384 | 2- trifluoromethyls | Q94 | H | H | But |
| I-385 | 2- trifluoromethyls | Q95 | H | H | But |
| I-386 | 2- trifluoromethyls | Q96 | H | H | But |
| I-387 | 2- trifluoromethyls | Q97 | H | H | But |
| I-388 | 2- trifluoromethyls | Q98 | H | H | But |
| I-389 | 2- trifluoromethyls | Q99 | H | H | But |
| I-390 | 2- trifluoromethyls | Q100 | H | H | But |
| I-391 | 2- trifluoromethyls | Q101 | H | H | But |
| I-392 | 2- trifluoromethyls | Q102 | H | H | But |
| I-393 | 2- trifluoromethyls | Q103 | H | H | But |
| I-394 | 2- trifluoromethyls | Q104 | H | H | But |
| I-395 | 2- trifluoromethyls | Q105 | H | H | But |
| I-396 | 2- trifluoromethyls | Q106 | H | H | But |
| I-397 | 2- trifluoromethyls | Q107 | H | H | But |
| I-398 | 2- trifluoromethyls | Q108 | H | H | But |
| I-399 | 2- trifluoromethyls | Q109 | H | H | But |
| I-400 | 2- trifluoromethyls | Q110 | H | H | But |
| I-401 | 2- trifluoromethyls | Q111 | H | H | But |
| I-402 | 2- trifluoromethyls | Q112 | H | H | Cl |
| I-403 | 4- chlorphenyls | Q113 | H | H | Cl |
| I-404 | 4- chlorphenyls | Q114 | H | H | But |
In upper table：Ph represents phenyl, ButRepresent the tert-butyl group, Q1-Q114Following structure is represented, wherein wave represents that this key is connected with other parts in logical formula (I).
Q1Represent
Q2RepresentQ3Represent
Q4Represent
Q5Represent
Q6Represent
Q7Represent
Q8RepresentQ9Represent
Q10Represent
Q11Represent
Q12Represent
Q13Represent
Q14Represent
Q15Represent
Q16Represent
Q17RepresentQ18Represent
Q19Represent
Q20Represent
Q21Represent
Q22RepresentQ23Represent
Q24Represent
Q25Represent
Q26Represent
Q27Represent
Q28Represent
Q29Represent
Q30Represent
Q31Represent
Q32Represent
Q33Represent
Q34Represent
Q35Represent
Q36Represent
Q37Represent
Q38Represent
Q39Represent
Q40Represent
Q41Represent
Q42Represent
Q43RepresentQ44RepresentQ45RepresentQ46Represent
Q47Represent
Q48RepresentQ49Represent
Q50Represent
Q51Represent
Q52Represent
Q53Represent
Q54Represent
Q55RepresentQ56Represent
Q57Represent
Q58Represent
Q59Represent
Q60RepresentQ61Represent
Q62Represent
Q63Represent
Q64Represent
Q65Represent
Q66Represent
Q67Represent
Q68RepresentQ69Represent
Q70Represent
Q71Represent
Q72Represent
Q73Represent
Q74Represent
Q75RepresentQ76RepresentQ77Represent
Q78Represent
Q79Represent
Q80RepresentQ81RepresentQ82Represent
Q83Represent
Q84Represent
Q85RepresentQ86Represent
Q87Represent
Q88Represent
Q89Represent
Q90Represent
Q91Represent
Q92Represent
Q93Represent
Q94Represent
Q95Represent
Q96RepresentQ97Represent
Q98Represent
Q99Represent
Q100RepresentQ101Represent
Q102Represent
Q103Represent
Q104RepresentQ105RepresentQ106Represent
Q107Represent
Q108RepresentQ109Represent
Q110Represent
Q111Represent
Q112RepresentQ113Represent
Q114Represent
(the wherein R of compound list 22For CHR14R15)
| Numbering | R1 | R15 | R14 | R3 | R5 | R4 |
| II-1 | 2,6- difluorophenyls | (CH2)2OCH3 | H | H | But | H |
| II-2 | 4- chlorphenyls | (CH2)2OCH3 | H | H | But | H |
| II-3 | 2- trifluoromethyls | (CH2)2OCH3 | H | H | But | H |
| II-4 | 3- (4- trifluoromethyl pyridines base) | (CH2)2OCH3 | H | H | But | H |
| II-5 | 3- (6- chloropyridines base) | (CH2)2OCH3 | H | H | But | H |
| II-6 | 5- (4- trifluoromethyl pyrimidines base) | (CH2)2OCH3 | H | H | But | H |
| II-7 | 4- (2- diurils oxazolyl) | (CH2)2OCH3 | H | H | But | H |
| II-8 | 5- (4- trifluoromethyl thiazoles base) | (CH2)2OCH3 | H | H | But | H |
| II-9 | 5- (2- methyl -4- trifluoromethyl thiazoles base) | (CH2)2OCH3 | H | H | But | H |
| II-10 | 5- (the chloro- 4- trifluoromethyl thiazoles bases of 2-) | (CH2)2OCH3 | H | H | But | H |
| II-11 | 5- (1- methyl-3-trifluoromethyl pyrazols base) | (CH2)2OCH3 | H | H | But | H |
| II-12 | 5- (1- methyl -3- ethyl pyrazolyls) | (CH2)2OCH3 | H | H | But | H |
| II-13 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | (CH2)2OCH3 | H | H | But | H |
| II-14 | 5- (1- (2- (3- chloropyridines base)) -3- bromines pyrazolyl) | (CH2)2OCH3 | H | H | But | H |
| II-15 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | (CH2)2OCH3 | H | H | But | H |
| II-16 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | (CH2)2OCH3 | H | H | But | H |
| II-17 | 4- chlorphenyls | CH2OCH2CF3 | H | H | But | H |
| II-18 | 2- trifluoromethyls | CH2OCH2CF3 | H | H | But | H |
| II-19 | 3- (4- trifluoromethyl pyridines base) | CH2OCH2CF3 | H | H | But | H |
| II-20 | 3- (6- chloropyridines base) | CH2OCH2CF3 | H | H | But | H |
| II-21 | 5- (4- trifluoromethyl pyrimidines base) | CH2OCH2CF3 | H | H | But | H |
| II-22 | 4- (2- diurils oxazolyl) | CH2OCH2CF3 | H | H | But | H |
| II-23 | 5- (4- trifluoromethyl thiazoles base) | CH2OCH2CF3 | H | H | But | H |
| II-24 | 5- (1- methyl -3- ethyl pyrazolyls) | CH2OCH2CF3 | H | H | But | H |
| II-25 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | CH2OCH2CF3 | H | H | But | H |
| II-26 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | CH2OCH2CF3 | H | H | But | H |
| II-27 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | CH2OCH2CF3 | H | H | But | H |
| II-28 | 4- chlorphenyls | CH2OCH2CN | H | H | But | H |
| II-29 | 2- trifluoromethyls | CH2OCH2CN | H | H | But | H |
| II-30 | 3- (4- trifluoromethyl pyridines base) | CH2OCH2CN | H | H | But | H |
| II-31 | 3- (6- chloropyridines base) | CH2OCH2CN | H | H | But | H |
| II-32 | 5- (4- trifluoromethyl pyrimidines base) | CH2OCH2CN | H | H | But | H |
| II-33 | 4- (2- diurils oxazolyl) | CH2OCH2CN | H | H | But | H |
| II-34 | 5- (4- trifluoromethyl thiazoles base) | CH2OCH2CN | H | H | But | H |
| II-35 | 5- (1- methyl -3- ethyl pyrazolyls) | CH2OCH2CN | H | H | But | H |
| II-36 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | CH2OCH2CN | H | H | But | H |
| II-37 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | CH2OCH2CN | H | H | But | H |
| II-38 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | CH2OCH2CN | H | H | But | H |
| II-39 | 4- chlorphenyls | CH2OCH2CO2CH3 | H | H | But | H |
| II-40 | 2- trifluoromethyls | CH2OCH2CO2CH3 | H | H | But | H |
| II-41 | 3- (4- trifluoromethyl pyridines base) | CH2OCH2CO2CH3 | H | H | But | H |
| II-42 | 3- (6- chloropyridines base) | CH2OCH2CO2CH3 | H | H | But | H |
| II-43 | 5- (4- trifluoromethyl pyrimidines base) | CH2OCH2CO2CH3 | H | H | But | H |
| II-44 | 4- (2- diurils oxazolyl) | CH2OCH2CO2CH3 | H | H | But | H |
| II-45 | 5- (4- trifluoromethyl thiazoles base) | CH2OCH2CO2CH3 | H | H | But | H |
| II-46 | 5- (1- methyl -3- ethyl pyrazolyls) | CH2OCH2CO2CH3 | H | H | But | H |
| II-47 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | CH2OCH2CO2CH3 | H | H | But | H |
| II-48 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | CH2OCH2CO2CH3 | H | H | But | H |
| II-49 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | CH2OCH2CO2CH3 | H | H | But | H |
| II-50 | 4- chlorphenyls | CH2OCH2CON(CH3)2 | H | H | But | H |
| II-51 | 2- trifluoromethyls | CH2OCH2CON(CH3)2 | H | H | But | H |
| II-52 | 3- (4- trifluoromethyl pyridines base) | CH2OCH2CON(CH3)2 | H | H | But | H |
| II-53 | 3- (6- chloropyridines base) | CH2OCH2CON(CH3)2 | H | H | But | H |
| II-54 | 5- (4- trifluoromethyl pyrimidines base) | CH2OCH2CON(CH3)2 | H | H | But | H |
| II-55 | 4- (2- diurils oxazolyl) | CH2OCH2CON(CH3)2 | H | H | But | H |
| II-56 | 5- (4- trifluoromethyl thiazoles base) | CH2OCH2CON(CH3)2 | H | H | But | H |
| II-57 | 5- (1- methyl -3- ethyl pyrazolyls) | CH2OCH2CON(CH3)2 | H | H | But | H |
| II-58 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | CH2OCH2CON(CH3)2 | H | H | But | H |
| II-59 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | CH2OCH2CON(CH3)2 | H | H | But | H |
| II-60 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | CH2OCH2CON(CH3)2 | H | H | But | H |
| II-61 | 4- chlorphenyls | CH2OCH2CONHCH3 | H | H | But | H |
| II-62 | 2- trifluoromethyls | CH2OCH2CONHCH3 | H | H | But | H |
| II-63 | 3- (4- trifluoromethyl pyridines base) | CH2OCH2CONHCH3 | H | H | But | H |
| II-64 | 3- (6- chloropyridines base) | CH2OCH2CONHCH3 | H | H | But | H |
| II-65 | 5- (4- trifluoromethyl pyrimidines base) | CH2OCH2CONHCH3 | H | H | But | H |
| II-66 | 4- (2- diurils oxazolyl) | CH2OCH2CONHCH3 | H | H | But | H |
| II-67 | 5- (4- trifluoromethyl thiazoles base) | CH2OCH2CONHCH3 | H | H | But | H |
| II-68 | 5- (1- methyl -3- ethyl pyrazolyls) | CH2OCH2CONHCH3 | H | H | But | H |
| II-69 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | CH2OCH2CONHCH3 | H | H | But | H |
| II-70 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | CH2OCH2CONHCH3 | H | H | But | H |
| II-71 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | CH2OCH2CONHCH3 | H | H | But | H |
| II-72 | 4- chlorphenyls | CON(CH3)2 | H | H | But | H |
| II-73 | 2- trifluoromethyls | CON(CH3)2 | H | H | But | H |
| II-74 | 3- (4- trifluoromethyl pyridines base) | CON(CH3)2 | H | H | But | H |
| II-75 | 3- (6- chloropyridines base) | CON(CH3)2 | H | H | But | H |
| II-76 | 5- (4- trifluoromethyl pyrimidines base) | CON(CH3)2 | H | H | But | H |
| II-77 | 4- (2- diurils oxazolyl) | CON(CH3)2 | H | H | But | H |
| II-78 | 5- (4- trifluoromethyl thiazoles base) | CON(CH3)2 | H | H | But | H |
| II-79 | 5- (1- methyl -3- ethyl pyrazolyls) | CON(CH3)2 | H | H | But | H |
| II-80 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | CON(CH3)2 | H | H | But | H |
| II-81 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | CON(CH3)2 | H | H | But | H |
| II-82 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | CON(CH3)2 | H | H | But | H |
| II-83 | 4- chlorphenyls | CONHCH3 | H | H | But | H |
| II-84 | 2- trifluoromethyls | CONHCH3 | H | H | But | H |
| II-85 | 3- (4- trifluoromethyl pyridines base) | CONHCH3 | H | H | But | H |
| II-86 | 3- (6- chloropyridines base) | CONHCH3 | H | H | But | H |
| II-87 | 5- (4- trifluoromethyl pyrimidines base) | CONHCH3 | H | H | But | H |
| II-88 | 4- (2- diurils oxazolyl) | CONHCH3 | H | H | But | H |
| II-89 | 5- (4- trifluoromethyl thiazoles base) | CONHCH3 | H | H | But | H |
| II-90 | 5- (1- methyl -3- ethyl pyrazolyls) | CONHCH3 | H | H | But | H |
| II-91 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | CONHCH3 | H | H | But | H |
| II-92 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | CONHCH3 | H | H | But | H |
| II-93 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | CONHCH3 | H | H | But | H |
| II-94 | 4- chlorphenyls | CONHCH3 | H | H | But | H |
| II-95 | 2- trifluoromethyls | CONHCH3 | H | H | But | H |
| II-96 | 3- (4- trifluoromethyl pyridines base) | CONHCH3 | H | H | But | H |
| II-97 | 3- (6- chloropyridines base) | CONHCH3 | H | H | But | H |
| II-98 | 5- (4- trifluoromethyl pyrimidines base) | CONHCH3 | H | H | But | H |
| II-99 | 4- (2- diurils oxazolyl) | CONHCH3 | H | H | But | H |
| II-100 | 5- (4- trifluoromethyl thiazoles base) | CONHCH3 | H | H | But | H |
| II-101 | 5- (1- methyl -3- ethyl pyrazolyls) | CONHCH3 | H | H | But | H |
| II-102 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | CONHCH3 | H | H | But | H |
| II-103 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | CONHCH3 | H | H | But | H |
| II-104 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | CONHCH3 | H | H | But | H |
| II-105 | 4- chlorphenyls | CO2CH3 | H | H | But | H |
| II-106 | 2- trifluoromethyls | CO2CH3 | H | H | But | H |
| II-107 | 3- (4- trifluoromethyl pyridines base) | CO2CH3 | H | H | But | H |
| II-108 | 3- (6- chloropyridines base) | CO2CH3 | H | H | But | H |
| II-109 | 5- (4- trifluoromethyl pyrimidines base) | CO2CH3 | H | H | But | H |
| II-110 | 4- (2- diurils oxazolyl) | CO2CH3 | H | H | But | H |
| II-111 | 5- (4- trifluoromethyl thiazoles base) | CO2CH3 | H | H | But | H |
| II-112 | 5- (1- methyl -3- ethyl pyrazolyls) | CO2CH3 | H | H | But | H |
| II-113 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | CO2CH3 | H | H | But | H |
| II-114 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | CO2CH3 | H | H | But | H |
| II-115 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | CO2CH3 | H | H | But | H |
| II-116 | 4- chlorphenyls | CO2CH3 | H | H | But | H |
| II-117 | 2- trifluoromethyls | CO2CH3 | H | H | But | H |
| II-118 | 3- (4- trifluoromethyl pyridines base) | CO2CH3 | H | H | But | H |
| II-119 | 3- (6- chloropyridines base) | CO2CH3 | H | H | But | H |
| II-120 | 5- (4- trifluoromethyl pyrimidines base) | CO2CH3 | H | H | But | H |
| II-121 | 4- (2- diurils oxazolyl) | CO2CH3 | H | H | But | H |
| II-122 | 5- (4- trifluoromethyl thiazoles base) | CO2CH3 | H | H | But | H |
| II-123 | 5- (1- methyl -3- ethyl pyrazolyls) | CO2CH3 | H | H | But | H |
| II-124 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | CO2CH3 | H | H | But | H |
| II-125 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | CO2CH3 | H | H | But | H |
| II-126 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | CO2CH3 | H | H | But | H |
| II-127 | 4- chlorphenyls | CH2N(CH3)2 | H | H | But | H |
| II-128 | 2- trifluoromethyls | CH2N(CH3)2 | H | H | But | H |
| II-129 | 3- (4- trifluoromethyl pyridines base) | CH2N(CH3)2 | H | H | But | H |
| II-130 | 3- (6- chloropyridines base) | CH2N(CH3)2 | H | H | But | H |
| II-131 | 5- (4- trifluoromethyl pyrimidines base) | CH2N(CH3)2 | H | H | But | H |
| II-132 | 4- (2- diurils oxazolyl) | CH2N(CH3)2 | H | H | But | H |
| II-133 | 5- (4- trifluoromethyl thiazoles base) | CH2N(CH3)2 | H | H | But | H |
| II-134 | 5- (1- methyl -3- ethyl pyrazolyls) | CH2N(CH3)2 | H | H | But | H |
| II-135 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | CH2N(CH3)2 | H | H | But | H |
| II-136 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | CH2N(CH3)2 | H | H | But | H |
| II-137 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | CH2N(CH3)2 | H | H | But | H |
| II-138 | Phenyl | P29 | H | H | But | H |
| II-139 | 2- trifluoromethyls | P29 | H | H | But | H |
| II-140 | 2- aminomethyl phenyls | P29 | H | H | But | H |
| II-141 | 3- chlorphenyls | P29 | H | H | But | H |
| II-142 | 2- chlorphenyls | P29 | H | H | But | H |
| II-143 | 4- chlorphenyls | P29 | H | H | But | H |
| II-144 | 4- bromophenyls | P29 | H | H | But | H |
| II-145 | 4- iodophenyls | P29 | H | H | But | H |
| II-146 | 4- nitrobenzophenones | P29 | H | H | But | H |
| II-147 | 4- aminomethyl phenyls | P29 | H | H | But | H |
| II-148 | 4- tert-butyl-phenyls | P29 | H | H | But | H |
| II-149 | 4- trifluoromethyls | P29 | H | H | But | H |
| II-150 | 3- trifluoromethyls | P29 | H | H | But | H |
| II-151 | The chloro- 4- methyl sulphonyls of 2- | P29 | H | H | But | H |
| II-152 | 2- nitro-4-methyl sulfonyls | P29 | H | H | But | H |
| II-153 | 2- trifluoromethyl -4- fluorophenyls | P29 | H | H | But | H |
| II-154 | 2- trifluoromethyl -4- methylsulfonyl phenyls | P29 | H | H | But | H |
| II-155 | 2,6- difluorophenyls | P29 | H | H | But | H |
| II-156 | 2- fluorophenyls | P29 | H | H | But | H |
| II-157 | 4- fluorophenyls | P29 | H | H | But | H |
| II-158 | 2- methoxyphenyls | P29 | H | H | But | H |
| II-159 | 4- methoxyphenyls | P29 | H | H | But | H |
| II-160 | 4- Trifluoromethoxyphen-ls | P29 | H | H | But | H |
| II-161 | 3,4- Dimethoxyphenyls | P29 | H | H | But | H |
| II-162 | 2- phenyls | P29 | H | H | But | H |
| II-163 | 2- ethylphenyls | P29 | H | H | But | H |
| II-164 | 2- isopropyl phenyls | P29 | H | H | But | H |
| II-165 | 2- tert-butyl-phenyls | P29 | H | H | But | H |
| II-166 | (4- chlorphenyls) methyl | P29 | H | H | But | H |
| II-167 | (4- chlorphenyls)-isopropyl-methyl | P29 | H | H | But | H |
| II-168 | 2,2-3,3- tetramethyl-ring propyl | P29 | H | H | But | H |
| II-169 | 2- (5- nitrofurans base) | P29 | H | H | But | H |
| II-170 | 2- (5- chlorine furyl) | P29 | H | H | But | H |
| II-171 | 2- (3- trifluoromethyls furyl) | P29 | H | H | But | H |
| II-172 | 2- (3- chlorine furyl) | P29 | H | H | But | H |
| II-173 | 3- (2- trifluoromethyls furyl) | P29 | H | H | But | H |
| II-174 | 3- (2- chlorine furyl) | P29 | H | H | But | H |
| II-175 | 2- (3- chlorothiophenes base) | P29 | H | H | But | H |
| II-176 | 2- (3 methyl thiophene base) | P29 | H | H | But | H |
| II-177 | 3- (2- iodothiophens base) | P29 | H | H | But | H |
| II-178 | 3- (2- methylthiophenes base) | P29 | H | H | But | H |
| II-179 | 3- (4- trifluoromethyl pyrpoles base) | P29 | H | H | But | H |
| II-180 | 3- (1- methyl -4- trifluoromethyl pyrpoles base) | P29 | H | H | But | H |
| II-181 | 2- (1- methylpyrroles base) | P29 | H | H | But | H |
| II-182 | 4- (5- tri- Fu Jia Ji oxazolyls) | P29 | H | H | But | H |
| II-183 | 4- (2- methyl -5- San Fu Jia Ji oxazolyls) | P29 | H | H | But | H |
| II-184 | 4- (2- diurils oxazolyl) | P29 | H | H | But | H |
| II-185 | 4- (5- trifluoromethyl thiazoles base) | P29 | H | H | But | H |
| II-186 | 4- (2- methyl -5- trifluoromethyl thiazoles base) | P29 | H | H | But | H |
| II-187 | 5- (the chloro- 4- trifluoromethyl thiazoles bases of 2-) | P29 | H | H | But | H |
| II-188 | 5- (2- cyano group -4- trifluoromethyl thiazoles base) | P29 | H | H | But | H |
| II-189 | 5- (2- methoxyl group -4- trifluoromethyl thiazoles base) | P29 | H | H | But | H |
| II-190 | 5- (2- methyl mercapto -4- trifluoromethyl thiazoles base) | P29 | H | H | But | H |
| II-191 | 5- (2- methyl sulphonyl -4- trifluoromethyl thiazoles base) | P29 | H | H | But | H |
| II-192 | 5- (4- trifluoromethyl thiazoles base) | P29 | H | H | But | H |
| II-193 | 5- (2- methyl -4- trifluoromethyl thiazoles base) | P29 | H | H | But | H |
| II-194 | 5- (2,4- bis- trifluoromethyl thiazole base) | P29 | H | H | But | H |
| II-195 | 5- (1- phenyl pyrazolines oxazolyl) | P29 | H | H | But | H |
| II-196 | 5- (1- phenyl -3- methylpyrazoles base) | P29 | H | H | But | H |
| II-197 | 5- (1,3- dimethyl pyrazole oxazolyl) | P29 | H | H | But | H |
| II-198 | 5- (1,3,4- trimethylpyrazol base) | P29 | H | H | But | H |
| II-199 | 5- (1- methyl -3- ethyl -4- chlorine pyrazolyl) | P29 | H | H | But | H |
| II-200 | 5- (1- methyl -3- ethyl pyrazolyls) | P29 | H | H | But | H |
| II-201 | 5- (1,3- dimethyl -4- chlorine pyrazolyl) | P29 | H | H | But | H |
| II-202 | 5- (1- phenyl -3- trifluoromethyl pyrazols base) | P29 | H | H | But | H |
| II-203 | 5- (1- methyl-3-trifluoromethyl pyrazols base) | P29 | H | H | But | H |
| II-204 | 5- (1- methyl -3- trifluoromethyl -4- chlorine pyrazolyl) | P29 | H | H | But | H |
| II-205 | 5- (1- phenyl -3- chlorine pyrazolyl) | P29 | H | H | But | H |
| II-206 | 5- (1- (2- pyridine radicals) -3- chlorine pyrazolyl) | P29 | H | H | But | H |
| II-207 | 5- (1- (2- pyridine radicals) -3- bromines pyrazolyl) | P29 | H | H | But | H |
| II-208 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | P29 | H | H | But | H |
| II-209 | 5- (1- (2- (3- chloropyridines base)) -3- bromines pyrazolyl) | P29 | H | H | But | H |
| II-210 | 5- (1- (2- (3- chloropyridines base)) -3- trifluoromethyl pyrazols base) | P29 | H | H | But | H |
| II-211 | 4- (1- phenyl -3- trifluoromethyl pyrazols base) | P29 | H | H | But | H |
| II-212 | 4- (1- methyl-3-trifluoromethyl pyrazols base) | P29 | H | H | But | H |
| II-213 | 4- (the chlorine pyrazolyl of 1- methyl -3- trifluoromethyls -5) | P29 | H | H | But | H |
| II-214 | 4- (1- methyl -5- trifluoromethyl pyrazols base) | P29 | H | H | But | H |
| II-215 | 3- (5- methyl-isoxazoles base) | P29 | H | H | But | H |
| II-216 | 3- (5- trifluoromethyls isoxazolyl) | P29 | H | H | But | H |
| II-217 | 4- (3- trifluoromethyls isoxazolyl) | P29 | H | H | But | H |
| II-218 | 4- (5- Trifluoromethyl-1s, 2,3 triazolyls) | P29 | H | H | But | H |
| II-219 | 5- (4- methyl isophthalic acids, 2,3 thiadiazolyl groups) | P29 | H | H | But | H |
| II-220 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazolyl groups) | P29 | H | H | But | H |
| II-221 | 3- (2- chloropyridines base) | P29 | H | H | But | H |
| II-222 | 3- (2- fluorine pyridine radicals) | P29 | H | H | But | H |
| II-223 | 3- (2- trifluoromethyl pyridines base) | P29 | H | H | But | H |
| II-224 | 3- (2- is cyanopyridine-based) | P29 | H | H | But | H |
| II-225 | 3- (2- methoxypyridines base) | P29 | H | H | But | H |
| II-226 | 3- (2- phenoxypyridines base) | P29 | H | H | But | H |
| II-227 | 3- (2- methylsulfanyl pyridines base) | P29 | H | H | But | H |
| II-228 | 3- (2- methylsulfonyl pyridines base) | P29 | H | H | But | H |
| II-229 | 3- (4- trifluoromethyl pyridines base) | P29 | H | H | But | H |
| II-230 | 3- (6- chloropyridines base) | P29 | H | H | But | H |
| II-231 | 3- (6- fluorine pyridine radicals) | P29 | H | H | But | H |
| II-232 | 3- (6- trifluoromethyl pyridines base) | P29 | H | H | But | H |
| II-233 | 3- (6- is cyanopyridine-based) | P29 | H | H | But | H |
| II-234 | 3- (6- methoxypyridines base) | P29 | H | H | But | H |
| II-235 | 3- (6- methylsulfonyl pyridines base) | P29 | H | H | But | H |
| II-236 | 3- (2,6- bis- chloro- 4- picolyls) | P29 | H | H | But | H |
| II-237 | 3- (2,6- dichlor-4-trifluoromethyl pyridine radicals) | P29 | H | H | But | H |
| II-238 | 4- pyridine radicals | P29 | H | H | But | H |
| II-239 | 5- (4- trifluoromethyl pyrimidines base) | P29 | H | H | But | H |
| II-240 | 5- (the chloro- 4- trifluoromethyl pyrimidines bases of 2-) | P29 | H | H | But | H |
| II-241 | 5- (2- methyl -4- trifluoromethyl pyrimidines base) | P29 | H | H | But | H |
| II-242 | 3- (5,6- dihydro -2- methyl isophthalic acids, 4- oxygen thiapyrans base) | P29 | H | H | But | H |
| II-243 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | P29 | H | H | But | H |
| II-244 | 4- chlorphenyls | P30 | H | H | But | H |
| II-245 | 2- trifluoromethyls | P30 | H | H | But | H |
| II-246 | 3- (4- trifluoromethyl pyridines base) | P30 | H | H | But | H |
| II-247 | 3- (6- chloropyridines base) | P30 | H | H | But | H |
| II-248 | 5- (4- trifluoromethyl pyrimidines base) | P30 | H | H | But | H |
| II-249 | 4- (2- diurils oxazolyl) | P30 | H | H | But | H |
| II-250 | 5- (4- trifluoromethyl thiazoles base) | P30 | H | H | But | H |
| II-251 | 5- (1- methyl -3- ethyl pyrazolyls) | P30 | H | H | But | H |
| II-252 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | P30 | H | H | But | H |
| II-253 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | P30 | H | H | But | H |
| II-254 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | P30 | H | H | But | H |
| II-255 | 4- chlorphenyls | P31 | H | H | But | H |
| II-256 | 2- trifluoromethyls | P31 | H | H | But | H |
| II-257 | 3- (4- trifluoromethyl pyridines base) | P31 | H | H | But | H |
| II-258 | 5- (1- methyl -3- ethyl pyrazolyls) | P31 | H | H | But | H |
| II-259 | 4- chlorphenyls | P33 | H | H | But | H |
| II-260 | 2- trifluoromethyls | P33 | H | H | But | H |
| II-261 | 3- (4- trifluoromethyl pyridines base) | P33 | H | H | But | H |
| II-262 | 5- (1- methyl -3- ethyl pyrazolyls) | P33 | H | H | But | H |
| II-263 | 4- chlorphenyls | P32 | H | H | But | H |
| II-264 | 2- trifluoromethyls | P32 | H | H | But | H |
| II-265 | 3- (4- trifluoromethyl pyridines base) | P32 | H | H | But | H |
| II-266 | 5- (1- methyl -3- ethyl pyrazolyls) | P32 | H | H | But | H |
| II-267 | 4- chlorphenyls | P34 | H | H | But | H |
| II-268 | 2- trifluoromethyls | P34 | H | H | But | H |
| II-269 | 3- (4- trifluoromethyl pyridines base) | P34 | H | H | But | H |
| II-270 | 5- (1- methyl -3- ethyl pyrazolyls) | P34 | H | H | But | H |
| II-271 | 2,6- difluorophenyls | P1 | H | H | But | H |
| II-272 | 4- chlorphenyls | P1 | H | H | But | H |
| II-273 | 2- trifluoromethyls | P1 | H | H | But | H |
| II-274 | 3- (4- trifluoromethyl pyridines base) | P1 | H | H | But | H |
| II-275 | 3- (6- chloropyridines base) | P1 | H | H | But | H |
| II-276 | 2- (6- (3- trifluoromethyls) pyridine radicals) | P1 | H | H | But | H |
| II-277 | 5- (4- trifluoromethyl pyrimidines base) | P1 | H | H | But | H |
| II-278 | 4- (2- diurils oxazolyl) | P1 | H | H | But | H |
| II-279 | 5- (4- trifluoromethyl thiazoles base) | P1 | H | H | But | H |
| II-280 | 5- (2- methyl -4- trifluoromethyl thiazoles base) | P1 | H | H | But | H |
| II-281 | 5- (the chloro- 4- trifluoromethyl thiazoles bases of 2-) | P1 | H | H | But | H |
| II-282 | 5- (1- methyl-3-trifluoromethyl pyrazols base) | P1 | H | H | But | H |
| II-283 | 5- (1- methyl -3- ethyl pyrazolyls) | P1 | H | H | But | H |
| II-284 | 5- (1- (2- (3- chloropyridines base)) -3- chlorine pyrazolyl) | P1 | H | H | But | H |
| II-285 | 5- (1- (2- (3- chloropyridines base)) -3- bromines pyrazolyl) | P1 | H | H | But | H |
| II-286 | 5- (4- Trifluoromethyl-1s, 2,3 thiadiazoles) | P1 | H | H | But | H |
| II-287 | 3- (5,6- dihydro -2- Trifluoromethyl-1s, 4- oxygen thiapyrans base) | P1 | H | H | But | H |
| II-288 | 2- trifluoromethyls | P2 | H | H | But | H |
| II-289 | 2- trifluoromethyls | P3 | H | H | But | H |
| II-290 | 2- trifluoromethyls | P5 | H | H | But | H |
| II-291 | 2- trifluoromethyls | P6 | H | H | But | H |
| II-292 | 2- trifluoromethyls | P7 | H | H | But | H |
| II-293 | 2- trifluoromethyls | P8 | H | H | But | H |
| II-294 | 2- trifluoromethyls | P9 | H | H | But | H |
| II-295 | 2- trifluoromethyls | P10 | H | H | But | H |
| II-296 | 2- trifluoromethyls | P11 | H | H | But | H |
| II-297 | 2- trifluoromethyls | P12 | H | H | But | H |
| II-298 | 2- trifluoromethyls | P13 | H | H | But | H |
| II-299 | 2- trifluoromethyls | P14 | H | H | But | H |
| II-300 | 2- trifluoromethyls | P15 | H | H | But | H |
| II-301 | 2- trifluoromethyls | P16 | H | H | But | H |
| II-302 | 2- trifluoromethyls | P17 | H | H | But | H |
| II-303 | 2- trifluoromethyls | P18 | H | H | But | H |
| II-304 | 2- trifluoromethyls | P4 | H | H | But | H |
| II-305 | 2- trifluoromethyls | P19 | H | H | But | H |
| II-306 | 2- trifluoromethyls | P20 | H | H | But | H |
| II-307 | 2- trifluoromethyls | P21 | H | H | But | H |
| II-308 | 2- trifluoromethyls | P22 | H | H | But | H |
| II-309 | 2- trifluoromethyls | P23 | H | H | But | H |
| II-310 | 2- trifluoromethyls | P24 | H | H | But | H |
| II-311 | 2- trifluoromethyls | P25 | H | H | But | H |
| II-312 | 2- trifluoromethyls | P26 | H | H | But | H |
| II-313 | 2- trifluoromethyls | (CH2)2OCH3 | H | Cl | But | H |
| II-314 | 2- trifluoromethyls | (CH2)2OCH3 | H | F | But | H |
| II-315 | 2- trifluoromethyls | (CH2)2OCH3 | H | Br | But | H |
| II-316 | 2- trifluoromethyls | (CH2)2OCH3 | H | I | But | H |
| II-317 | 2- trifluoromethyls | (CH2)2OCH3 | H | CH3 | But | H |
| II-318 | 2- trifluoromethyls | (CH2)2OCH3 | CH3 | H | But | H |
| II-319 | 2- trifluoromethyls | (CH2)2OCH3 | CN | H | But | H |
| II-320 | 2- trifluoromethyls | (CH2)2OCH3 | H | Cl | But | Cl |
| II-321 | 2- trifluoromethyls | CH2OCH2CF3 | H | Cl | But | H |
| II-322 | 2- trifluoromethyls | CH2OCH2CF3 | H | F | But | H |
| II-323 | 2- trifluoromethyls | CH2OCH2CF3 | H | Br | But | H |
| II-324 | 2- trifluoromethyls | CH2OCH2CF3 | H | I | But | H |
| II-325 | 2- trifluoromethyls | CH2OCH2CF3 | H | CH3 | But | H |
| II-326 | 2- trifluoromethyls | CH2OCH2CF3 | CH3 | H | But | H |
| II-327 | 2- trifluoromethyls | CH2OCH2CF3 | CN | H | But | H |
| II-328 | 2- trifluoromethyls | CH2OCH2CF3 | H | Cl | But | Cl |
| II-329 | 2- trifluoromethyls | CH2OCH2CN | H | Cl | But | H |
| II-330 | 2- trifluoromethyls | CH2OCH2CN | H | F | But | H |
| II-331 | 2- trifluoromethyls | CH2OCH2CN | H | Br | But | H |
| II-332 | 2- trifluoromethyls | CH2OCH2CN | H | I | But | H |
| II-333 | 2- trifluoromethyls | CH2OCH2CN | H | CH3 | But | H |
| II-334 | 2- trifluoromethyls | CH2OCH2CN | CH3 | H | But | H |
| II-335 | 2- trifluoromethyls | CH2OCH2CN | CN | H | But | H |
| II-336 | 2- trifluoromethyls | CH2OCH2CN | H | Cl | But | Cl |
| II-337 | 2- trifluoromethyls | CH2OCH2CO2CH3 | H | Cl | But | H |
| II-338 | 2- trifluoromethyls | CH2OCH2CO2CH3 | H | F | But | H |
| II-339 | 2- trifluoromethyls | CH2OCH2CO2CH3 | H | Br | But | H |
| II-340 | 2- trifluoromethyls | CH2OCH2CO2CH3 | H | l | But | H |
| II-341 | 2- trifluoromethyls | CH2OCH2CON(CH3)2 | H | Cl | But | H |
| II-342 | 2- trifluoromethyls | CH2OCH2CON(CH3)2 | H | F | But | H |
| II-343 | 2- trifluoromethyls | CH2OCH2CON(CH3)2 | H | Br | But | H |
| II-344 | 2- trifluoromethyls | CH2OCH2CON(CH3)2 | H | I | But | H |
| II-345 | 2- trifluoromethyls | CH2OCH2CON(CH3)2 | H | CH3 | But | H |
| II-346 | 2- trifluoromethyls | CH2OCH2CON(CH3)2 | CH3 | H | But | H |
| II-347 | 2- trifluoromethyls | CH2OCH2CON(CH3)2 | CN | H | But | H |
| II-348 | 2- trifluoromethyls | CH2OCH2CON(CH3)2 | H | Cl | But | Cl |
| II-349 | 2- trifluoromethyls | CH2OCH2CONHCH3 | H | Cl | But | H |
| II-350 | 2- trifluoromethyls | CH2OCH2CONHCH3 | H | F | But | H |
| II-351 | 2- trifluoromethyls | CH2OCH2CONHCH3 | H | CH3 | But | H |
| II-352 | 2- trifluoromethyls | CH2OCH2CONHCH3 | CH3 | H | But | H |
| II-353 | 2- trifluoromethyls | CH2OCH2CONHCH3 | CN | H | But | H |
| II-354 | 2- trifluoromethyls | CH2OCH2CONHCH3 | H | Cl | But | Cl |
| II-355 | 2- trifluoromethyls | CON(CH3)2 | CN | H | But | H |
| II-356 | 2- trifluoromethyls | CON(CH3)2 | H | Cl | But | Cl |
| II-357 | 2- trifluoromethyls | CON(CH3)2 | H | Cl | But | H |
| II-358 | 2- trifluoromethyls | CON(CH3)2 | H | F | But | H |
| II-359 | 2- trifluoromethyls | CON(CH3)2 | H | CH3 | But | H |
| II-360 | 2- trifluoromethyls | CON(CH3)2 | CH3 | H | But | H |
| II-361 | 2- trifluoromethyls | CON(CH3)2 | CN | H | But | H |
| II-362 | 2- trifluoromethyls | CON(CH3)2 | H | Cl | But | Cl |
| II-363 | 2- trifluoromethyls | CONHCH3 | H | Cl | But | H |
| II-364 | 2- trifluoromethyls | CONHCH3 | CN | H | But | H |
| II-365 | 2- trifluoromethyls | CONHCH3 | CH3 | H | But | H |
| II-366 | 2- trifluoromethyls | CONHCH3 | H | CH3 | But | Cl |
| II-367 | 2- trifluoromethyls | CO2CH3 | H | Cl | But | H |
| II-368 | 2- trifluoromethyls | CO2CH3 | H | F | But | H |
| II-369 | 2- trifluoromethyls | CO2CH3 | H | Br | But | H |
| II-370 | 2- trifluoromethyls | CO2CH3 | H | I | But | H |
| II-371 | 2- trifluoromethyls | CO2CH3 | H | CH3 | But | H |
| II-372 | 2- trifluoromethyls | CO2CH3 | CH3 | H | But | H |
| II-373 | 2- trifluoromethyls | CO2CH3 | CN | H | But | H |
| II-374 | 2- trifluoromethyls | CO2CH3 | H | Cl | But | Cl |
| II-375 | 2- trifluoromethyls | P29 | H | Cl | But | H |
| II-376 | 2- trifluoromethyls | P29 | H | F | But | H |
| II-377 | 2- trifluoromethyls | P29 | H | Br | But | H |
| II-378 | 2- trifluoromethyls | P29 | H | I | But | H |
| II-379 | 2- trifluoromethyls | P29 | H | CH3 | But | H |
| II-380 | 2- trifluoromethyls | P29 | CH3 | H | But | H |
| II-381 | 2- trifluoromethyls | P29 | CN | H | But | H |
| II-382 | 2- trifluoromethyls | P29 | H | Cl | But | Cl |
| II-383 | 2- trifluoromethyls | P1 | H | F | But | H |
| II-384 | 2- trifluoromethyls | P1 | CN | H | But | H |
| II-385 | 2- trifluoromethyls | P1 | CH3 | H | But | H |
| II-386 | 2- trifluoromethyls | P1 | H | CH3 | But | Cl |
| II-387 | 2- trifluoromethyls | P1 | H | Cl | But | H |
| II-388 | 2- trifluoromethyls | P1 | H | Cl | But | Cl |
| II-389 | 2- trifluoromethyls | P19 | H | Cl | But | H |
Ph represents phenyl, Bu in upper tabletRepresent the tert-butyl group, wave represents that this key is connected P with other parts in logical formula (I)1-P28Structure it is the same, P29-P34Represent following structure：
P29For
P30For
P31For
P32For
P33For
P34For
The acarid that substituted cyanoacetate compound shown in the logical formula (I) of the present invention can be effectively directed to is garden pest, such as cotton spider mites, Tetranychus cinnabarinus (Carmine spider mite), the full pawl of citrus full (citrus red mite), god Ze Shi leaves (kanzawa spidermite), mite apple tetranychus (fruit tree red) (European red mite), the tarsonemid of tea half (broad mite), citrus rust full (pink citrusrust), Rhizoglyphus hyacinthi (bulb mite).
Substituted cyanoacetate compound shown in the logical formula (I) of the present invention also can be effectively for indoor acarid, such as flour mite, wheat food mite, tarsonemid.
Even if with low concentration in use, the substituted cyanoacetate compound of the present invention also shows that the effect of preventing and kill off of excellent acarid for various acarids.Terminology used in the present invention " acarid is prevented and kill off " means there is acaricidal activity in each stage (such as ovum, larva, adult) of acarid life cycle.
The substituted cyanoacetate compound of the present invention shows the effect of preventing and kill off of excellent acarid in the long-time of 14-40 days.
Drug-fast acarid is generated to traditional acaricide even for those, substituted cyanoacetate compound of the invention also shows that the effect of preventing and kill off of excellent acarid.
In terms of security, the substituted cyanoacetate compound of the present invention is satisfactory, they do not influence the beneficial insects such as plant, honeybee, trichogramma evanescens (Trichogramma evanescens), Encarsia formosa (Enscarsia formosa), small dark-coloured flower stinkbug (minutepirate bug) (minute pirate bugs (Orius spp)), beneficial mite such as Phyloseiulus nersimilis (Phytoseiulus persimilis) etc..
When the cyanoacetate compound shown in the logical formula (I) of the present invention is used for agricultural use, usual amount of application is 0.1-500 grams/1000 square metres, preferably 0.5-200 grams/1000 square metres.When the composition of the invention of the forms such as emulsifiable concentrate, wettable powder, flowable to be diluted with water to application concentration usually 1-1000ppm, preferably 1-500ppm in use, active component.When the acaricide containing logical formula (I) compound of the invention in forms such as granula, pulvis in use, can directly be applied without dilution.
Although being enumerated above the amount and concentration of administration, according to different situations such as the species of preparation, time of application, place to use, application process, pest species, the extent of damages, the amount and concentration of administration can be increased or decreased suitably.
The compound of the present invention may be used as acaricide and insecticide in itself.It is preferred that it is mixed with solid-state carrier, liquid carrier or gaseous carrier (spray), surfactant and other auxiliary agents are added if necessary；According to known compound method, various forms, such as oil solution, emulsifiable concentrate, wettable powder, flowable, pulvis, smoke agent or fumigant can be configured to.The cyanoacetate compound of the present invention is generally with 0.01-99% weight, and preferably the ratio of 0.1-50% weight is comprising in these formulations.Therefore present invention additionally comprises a kind of insecticide acaricide composition, logical formula (I) compound is contained as active component, and carrier and/or surfactant, the weight content of active component is 0.01-99% in composition.
The carrier and/or surfactant commonly used in known acaricide and insecticide are used equally in the composition of the present invention.If necessary can also be containing other auxiliary agents such as sticking agent, dispersant, stabilizer in composition.
The compounds of this invention can be mixed together with other active materials such as insecticide, attractant, disinfectant, acaricide, nematicide, fungicide, growth regulator or herbicide etc..
Embodiment
The present invention is described in more detail below with reference to preparation example, preparation example and biological activity test example, but these embodiments are not intended to limit the scope of the invention.
The compound I-25 of example 1 preparation
(1), to the preparation of tert-butyl benzene acetonitrile
Weigh 20 grams of Cymags to be dissolved in 30 milliliters of water, stirring is allowed to be completely dissolved, in the ethanol for adding 100 milliliters.75 DEG C are warming up to, 68 grams of 4 tert butylbenzyl chlorides are slowly added dropwise, is reacted 8 hours at 75-80 DEG C.Thin-layer chromatography shows that raw material reaction is complete, adds 30 grams of Anhydrous potassium carbonates, adjusts reacting liquid pH value to 8~9.Decompression boils off ethanol, plus 100 milliliters of water.It is extracted with ethyl acetate (100ml × 2), merges organic layer, and is washed with water (20ml × 2), saturated common salt washing (20ml × 2),
Anhydrous magnesium sulfate is dried.Column chromatography obtains 42 grams of products.
(2), the preparation of 2- (4- tert-butyl-phenyls)-cyan-acetic ester
Weigh in the round-bottomed flask that 3.5 grams of sodium hydride (60% content) adds 500 milliliters, add 120 milliliters of dry tetrahydrofurans, 15 grams be dissolved in 10 milliliters of tetrahydrofurans are added drop-wise in reaction solution to tert-butyl benzene acetonitrile.Dropping temperature is 0-5 DEG C, finishes within about 20 minutes, is gradually increased to room temperature.12 grams of diethyl carbonate solution for being dissolved in 100 milliliters of tetrahydrofurans are slowly added dropwise thereto again.Completion of dropping, is heated to reflux 4 hours, and thin-layer chromatography shows that raw material reaction is complete.Solvent evaporated, plus little water, watery hydrochloric acid regulation pH is 2 or so.Ethyl acetate extracts (200ml × 2), merges organic layer, and organic layer washing (30ml × 2), saturated common salt washing (30ml × 2), anhydrous magnesium sulfate is dried.Column chromatography obtains 2.8 grams of yellow oil.
Nuclear magnetic data (1HNMR, 300MHz, internal standard TMS, solvent C DCl3), δ ppm：1.32 (9H, s), 1.27-1.30 (3H, t), 4.23-4.25 (2H, q), 4.60 (1H, s), 7.40 (2H, d), 7.42 (2H, d).
(3), the preparation of 2- (4- tert-butyl-phenyls)-cyanoacetic acid 2- (phenyl) ethyl ester
Weigh 5 grams of 2- (4- tert-butyl-phenyls)-cyan-acetic ester, 6 grams of 2- phenylethanols to add in 100 milliliters of round-bottomed flask, plus one and drip butyl titanate, be warming up to 100 DEG C, react 12 hours.Thin-layer chromatography shows that raw material reaction is complete.Add little water into reaction solution, be extracted with ethyl acetate (100ml × 3), merge organic layer.Organic layer washes (20ml × 2), and saturated common salt washing (20ml × 2), anhydrous magnesium sulfate is dried.Column chromatography obtains 4.0 grams of white solid, fusing point：56-58℃.
Nuclear magnetic data (1HNMR, 300MHz, internal standard TMS, solvent C DCl3), δ ppm：1.32 (9H, s), 2.92-2.97 (2H, t), 4.37-4.41 (2H, t), 4.66 (1H, s), 7.11-7.12 (1H, d), 7.13-7.33 (4H, m), 7.37-7.45 (4H, m).
(4), compound I-25 preparation
0.3 gram of sodium hydride (60% content) and 10 milliliters of tetrahydrofurans are added in 125 milliliters of round-bottomed flasks, the 1.6 grams of 2- (4- tert-butyl-phenyls) being dissolved in 10 milliliters of tetrahydrofurans-cyanoacetic acid 2- (phenyl) ethyl ester is added drop-wise in reaction solution in the range of 0-5 DEG C, after reaction 30 minutes, 3.6 grams of 2- (trifluoromethyl)-chlorobenzoyl chlorides being dissolved in 10 milliliters of tetrahydrofurans are slowly dropped in reaction solution again, completion of dropping, room temperature is gradually heating to, is reacted 4 hours.Tetrahydrofuran is removed under reduced pressure, little water is added, watery hydrochloric acid regulation pH is 2 or so.Ethyl acetate extracts (30ml × 2), merges organic phase, and (20ml × 2), saturated common salt washing (20ml × 2) is washed with water, and anhydrous magnesium sulfate is dried.Column chromatography obtains 2.3 grams, fusing point：92-94℃.
Nuclear magnetic data (1HNMR, 300MHz, internal standard TMS, solvent C DCl3), δ ppm：1.32 (9H, s), 2.98-3.03 (4H, t), 4.43-4.54 (2H, m), 7.00-7.03 (1H, d), 7.19-7.31 (4H, m), 7.41-7.56 (7H, m), 7.76-7.79 (1H, d).
The compound II-139 of example 2 preparation
(1), the preparation of 2- (4- tert-butyl-phenyls)-cyanoacetic acid (2- tetrahydrofuran bases) methyl ester
Weigh 5 grams of 2- (4- tert-butyl-phenyls)-cyan-acetic ester, 6 grams of tetrahydrofurfuryl alcohols to add in 100 milliliters of round-bottomed flask, plus one and drip butyl titanate, be warming up to 100 DEG C, react 12 hours.Thin-layer chromatography shows that raw material reaction is complete.Add little water into reaction solution, be extracted with ethyl acetate (100ml × 3), merge organic layer.Organic layer washing (20ml × 2), saturated common salt washing (20ml × 2), anhydrous magnesium sulfate are dried.Column chromatography obtains 7.6 grams of grease.
Nuclear magnetic data (1HNMR, 300MHz, internal standard TMS, solvent C DCl3), δ ppm：1.32 (9H, s), 1.48-1.68 (1H, m), 1.85-1.90 (3H, m), 3.77-3.80 (2H, m), 4.12-4.15 (2H, m), 4.22-4.25 (1H, m), 4.77 (1H, s), 7.37-7.50 (4H, m).
(2), compound II-139 preparation
0.53 gram of sodium hydride (60% content) and 10 milliliters of tetrahydrofurans are added in 125 milliliters of round-bottomed flasks, 3 grams of 2- (4- tert-butyl-phenyls)-cyanoacetic acid (2- tetrahydrofuran bases) methyl ester for being dissolved in 10 milliliters of tetrahydrofurans is added drop-wise in reaction solution in the range of 0-5 DEG C, after reaction 30 minutes, 1.9 grams of 2- (trifluoromethyl)-chlorobenzoyl chlorides for being dissolved in 10 milliliters of tetrahydrofurans are slowly dropped in reaction solution again, add after finishing, room temperature is gradually heating to, is reacted 4 hours.Tetrahydrofuran is removed under reduced pressure, little water is added, watery hydrochloric acid regulation pH is 2 or so.Ethyl acetate extracts (20ml × 2), merges organic phase, and (20ml × 2), saturated common salt washing (20ml × 2) is washed with water, and anhydrous magnesium sulfate is dried.Column chromatography obtains 2.0 grams of oily maters.
Nuclear magnetic data (1HNMR, 300MHz, internal standard TMS, solvent C DCl3), δ ppm：1.31 (9H, s), 1.63-2.45 (4H, m), 3.65-3.68 (2H, m), 4.32-4.34 (3H, m), 7.31-4.15 (2H, m), 7.48-7.51 (4H, m), 7.56-7.59 (4H, m).
Compound I-47 fusing point：84-86 DEG C, nuclear magnetic data (1HNMR, 300MHz, internal standard TMS, solvent C DCl3), δ ppm：1.34 (9H, s), 2.00-2.05 (4H, m), 2.67-2.72 (4H, t), 4.26-4.34 (2H, m), 7.04-7.05 (1H, d), 7.15-7.29 (4H, m), 7.46-7.61 (7H, m), 7.78 (1H, d).
Formulation examples
The composition for preventing and treating harmful mite class, Plant nematode or insect has been illustrated in the embodiment of lower series preparation, and these compositions include the compounds of this invention as active component, the compound as prepared described in embodiment.Composition described in embodiment can be each diluted to obtains Sprayable composition suitable for the concentration in Field information.The general chemical descriptor (following related to percentage is all percetage by weight, and number is parts by weight) of each composition used in the embodiment being set forth below is as follows：
Preparation example 1 (missible oil)
10 parts of each compounds of the invention are dissolved in 45 parts of peaceful newborn 34# and 45 part of DMFs, these compositions are stirred and mixed, 10% emulsifiable concentrate is obtained.
Preparation example 2 (wettable powder)
In the mixture that 20 parts of each compounds of the invention are added to 2 parts of NaLSs, 4 parts of sodium lignin sulfonates, the oxidizing aqueous silicon attritive powder of 20 parts of synthesis and 54 parts of clays, these compositions are stirred by agitator and mixed, 20% wettable powder is obtained.
Preparation example 3 (granula)
5 parts of each compounds of the invention are mixed with 2 parts of neopelexes, 10 parts of bentonites and 83 parts of clays, are sufficiently stirred for afterwards.Appropriate water is added, mixture is again stirring for.Granulate and be air-dried by comminutor, obtain 5% granula.
Preparation example 4 (pulvis)
1 part of each compound of the invention is dissolved in appropriate acetone, oxidizing aqueous silicon attritive powder, 0.3 part of tributyl phosphate and the 93.7 parts of clays of 5 parts of synthesis are added into this solution, is stirred mix by agitator afterwards.Acetone is therefrom removed by evaporation, 1% pulvis is obtained.
Biological activity determination example
Indoor acaricidal activity method for measuring is as follows：
Testing compound is diluted to required concentration with the water containing 0.1% Tween 80 with after the mixed solvent dissolving of acetone/methanol (1: 1).With Tetranychus cinnabarinus (Tetranychus cinnabarinus) for target, acaricidal activity measure is carried out using airbrush spray-on processes, the pressure of airbrush spraying treatments (is roughly equal to 0.7kg/cm for 10psi2), spouting liquid is 0.5 milliliter.The death rate of 2-3 days investigation targets after processing.
Part of compounds Activity Results are as follows：
Under 40ppm dosage, the mite such as compound I-25, the II-139 death rate is that 100%, the I-47 mites death rate is more than 65%.
Under 10ppm dosage, compound I-25 is more than 95% to the mite death rate, and compound II-139 is more than 85% to the mite death rate.
Under 2.5ppm dosage, the compound I-25 mites death rate is more than 70%, and the compound II-139 mites death rate is more than 60%.
Field test method is as follows：
Carried out with reference to acaricide field test national standard method, subjects are citrus red mite (Panonychus citri).After noval chemical compound active compound acetone solution, a series of concentration are diluted to the water containing 0.1% Tween 80.Using engine-driven atomiser spraying treatment, spouting liquid is 1000L/hm2, each 3 repetitions of processing are often repeated not less than 2 branches, profusely radix in investigation at least 20 before often reprocessing, and respectively investigation is once survived mite number by 3d, 7d, 14d, 21d after processing, and mite mouthful decline rate and Rectifying efficacies are calculated according to below equation：
The result that field acaricidal activity is determined is as follows：
The field miticidal effect of compound
Claims (7)
1st, a kind of substituted cyanoacetate compound, as shown in logical formula (I)：
In formula：
R1Selected from C1-C6Alkyl, C1-C6Haloalkyl, the C of phenyl substitution1-C6Alkyl, C2-C6Alkenyl, C2-C6Haloalkenyl group, C2-C6Alkynyl, C2-C6Halo alkynyl, C3-C7Cycloalkyl, C3-C7Halogenated cycloalkyl, vinyl halides base C3-C7Cycloalkyl, R6Or R7；
R2Selected from R8Or R9；
R3、R4、R5It is independently selected from CN, halogen or R17；
R6Selected from unsubstituted or substituted phenyl, described substituent is selected from 1-5 following radicals：Halogen, C1-C6- alkyl, C1-C6Haloalkyl, C1-C6Alkoxy, C1-C6Halogenated alkoxy, CN, NO2、SOnR17、COR17、COOR17、CONR17R18、SO2NR17R18Or OR17；
R7Selected from unsubstituted or substituted fragrant heterocyclic radical, described substituent is selected from one or more following radicals：Halogen, C1-C6Alkyl, C1-C6Haloalkyl, C1-C6Alkoxy, C1-C6Halogenated alkoxy, CN, NO2、SOnR16、COR16、COOR17、CONR17R18、SO2NR17R18、OR17Or halogenophenyl, described fragrant heterocyclic radical is selected from pyridine radicals, pyrimidine radicals, pyridazinyl, pyrazinyl, triazine radical, thienyl, thiazolyl, thiadiazolyl group, oxazolyl, isoxazolyls, furyl, pyrrole radicals, pyrazolyl, imidazole radicals, triazolyl or Isosorbide-5-Nitrae-oxygen thiapyran；
R8Selected from R6、R7、R10、R11、R12Or R13；
R9Selected from CHR14R15；
R10Selected from the R replaced with following groups16：R6Or R7；
R11Selected from the R replaced with following groups16：XR6Or XR7；
R12Selected from the R replaced with following groups16：COOR6、COOR7、CONR6R12、CONR7R17、SO2NR6R17、SO2NR7R17、NHSO2R6Or NHSO2R7；
R13It is selected from：
R14Selected from CN or R17；
R15Selected from CN, COOR17、CONR17R18、CH2CH2OCH3, nonaromatic heterocycles base or the C replaced by following groups1-C6Alkyl：CN、COOR17、CONR17R18、NR17R18、R19、OCH2CN、OCH2COOR16、OCH2CONR17R18、OCH2CF3、C3-C6Cycloalkyl oxy, C3-C6Cycloalkenyl oxy, C3-C6Non-aromatic heterocyclylalkyl epoxide, C3-C6Nonaromatic heterocycles alkenyl epoxide, C3-C6Cycloalkylsulfanyl, C3-C6Cycloalkenyl group sulfenyl, C3-C6Non-aromatic heterocyclylalkyl sulfenyl or C3-C6Nonaromatic heterocycles enylsulfanyl；Described nonaromatic heterocycles base is selected from tetrahydrofuran, thiophane, nafoxidine, tetrahydro-thiazoles, tetrahydro-pyrazole, imidazolidine, tetrahydrochysene triazole, hexahydropyridine or hexahydro pyrans；
R16Selected from C1-C6Alkyl, C1-C6Haloalkyl, C2-C6Alkenyl, C2-C6Haloalkenyl group, C2-C6Alkynyl, C2-C6Halo alkynyl or C3-C6- cycloalkyl；
R17、R18It is independently selected from hydrogen or R16；
R19Selected from P1-P28In any one group：
P1： P2： P3：
P4： P5： P6：
P7： P8： P9：
P10： P11： P12：
P13： P14： P15：
P16： P17： P18：
P19： P20： P21：
P22： P23： P24：
P25： P26： P27：
P28：
X is selected from O, S or NR17；
N is 0-2 integer.
2nd, according to the substituted cyanoacetate compound described in claim 1, it is characterised in that：In logical formula (I)
R1Selected from C3-C7Halogenated cycloalkyl, vinyl halides base C3-C7Cycloalkyl, R6Or R7；
R2Selected from R8Or R9；
R3、R4、R5It is independently selected from CN, halogen or R17；
R6Selected from unsubstituted or substituted phenyl, described substituent is selected from 1-5 following radicals：Halogen, C1-C4- alkyl, C1-C4Haloalkyl, C1-C4Alkoxy, C1-C4Halogenated alkoxy, CN, NO2、SOnR17、COR17、COOR17、CONR17R18、SO2NR17R18Or OR17；
R7Selected from unsubstituted or substituted fragrant heterocyclic radical, described substituent is selected from 1-3 following radicals：Halogen, C1-C4Alkyl, C1-C4Haloalkyl, C1-C4Alkoxy, C1-C4Halogenated alkoxy, CN, NO2、SOnR16、COR16、COOR17、CONR17R18、SO2NR17R18、OR17Or halogenophenyl, described fragrant heterocyclic radical is selected from pyridine radicals, pyrimidine radicals, pyridazinyl, pyrazinyl, triazine radical, thienyl, thiazolyl, thiadiazolyl group, oxazolyl, isoxazolyls, furyl, pyrrole radicals, pyrazolyl, imidazole radicals, triazolyl or Isosorbide-5-Nitrae-oxygen thiapyran；
R8Selected from R6、R7、R10、R11、R12Or R13；
R9Selected from CHR14R15；
R10Selected from the R replaced with following groups16：R6Or R7；
R11Selected from the R replaced with following groups16：XR6Or XR7；
R12Selected from the R replaced with following groups16：COOR6、COOR7、CONR6R12、CONR7R17、SO2NR6R17、SO2NR7R17、NHSO2R6Or NHSO2R7；
R13It is selected from：
R14Selected from CN or R17；
R15Selected from CN, COOR17、CONR17R18、CH2CH2OCH3, nonaromatic heterocycles base or the C replaced by following groups1-C4Alkyl：CN、COOR17、CONR17R18、NR17R18、R19、OCH2CN、OCH2COOR16、OCH2CONR17R18、OCH2CF3、C3-C6Cycloalkyl oxy, C3-C6Cycloalkenyl oxy, C3-C6Non-aromatic heterocyclylalkyl epoxide, C3-C6Nonaromatic heterocycles alkenyl epoxide, C3-C6Cycloalkylsulfanyl, C3-C6Cycloalkenyl group sulfenyl, C3-C6Non-aromatic heterocyclylalkyl sulfenyl, C3-C6Nonaromatic heterocycles enylsulfanyl.Described nonaromatic heterocycles base is selected from tetrahydrofuran, thiophane, nafoxidine, tetrahydro-thiazoles, tetrahydro-pyrazole, imidazolidine, tetrahydrochysene triazole, hexahydropyridine or hexahydro pyrans；
R16Selected from C1-C4Alkyl, C1-C4Haloalkyl, C2-C4Alkenyl, C2-C4Haloalkenyl group, C2-C4Alkynyl, C2-C4Halo alkynyl or C3-C6- cycloalkyl；
R17、R18It is independently selected from hydrogen or R16；
R19Selected from following groups：P1、P2、P3、P5、P7、P8、P9、P12、P13、P14、P15、P16、P17、P19、P20、P21、P22、P23、P24、P25、P26、P27Or P28；
X is selected from O, S or NR17；
N is 0-2 integer.
3rd, substituted cyanoacetate compound according to claim 2, it is characterised in that：In logical formula (I)
R1Selected from R6Or R7；
R2Selected from R8Or R9；
R3、R4、R5It is independently selected from CN, halogen or R17；
R6Selected from unsubstituted or substituted phenyl, described substituent is selected from 1-5 following radicals：Halogen, C1-C4Alkyl, C1-C4Haloalkyl, NO2Or SOnR9；
R7Selected from unsubstituted or substituted fragrant heterocyclic radical, described substituent is selected from 1-3 following radicals：Halogen, C1-C4Alkyl, C1-C4Haloalkyl, NO2、SOnR9, described fragrant heterocyclic radical is selected from pyridine radicals, pyrimidine radicals, pyridazinyl, pyrazinyl, triazine radical, thienyl, thiazolyl, thiadiazolyl group, oxazolyl, isoxazolyls, furyl, pyrrole radicals, pyrazolyl, imidazole radicals, triazolyl or Isosorbide-5-Nitrae-oxygen thiapyran；
R8Selected from R6、R7、R10、R11、R12Or R13；
R9Selected from CHR14R15；
R10Selected from the R replaced with following groups16：R6Or R7；
R11Selected from the R replaced with following groups16：XR6Or XR7；
R12Selected from the R replaced with following groups16：COOR6、COOR7、CONR6R12、CONR7R17、SO2NR6R17、SO2NR7R17、NHSO2R6Or NHSO2R7；
R13It is selected from：
R14Selected from CN or R17；
R15Selected from CN, COOR17、CONR17R18、CH2CH2OCH3, nonaromatic heterocycles base or the C replaced by following groups1-C4Alkyl：CN、COOR17、CONR17R18、NR17R18、R19、OCH2CN、OCH2COOR16、OCH2CONR17R18、OCH2CF3、C3-C6Cycloalkyl oxy, C3-C6Cycloalkenyl oxy, C3-C6Non-aromatic heterocyclylalkyl epoxide, C3-C6Nonaromatic heterocycles alkenyl epoxide, C3-C6Cycloalkylsulfanyl, C3-C6Cycloalkenyl group sulfenyl, C3-C6Non-aromatic heterocyclylalkyl sulfenyl, C3-C6Nonaromatic heterocycles enylsulfanyl；Described nonaromatic heterocycles base is selected from tetrahydrofuran, thiophane, nafoxidine, tetrahydro-thiazoles, tetrahydro-pyrazole, imidazolidine, tetrahydrochysene triazole, hexahydropyridine or hexahydro pyrans.
R16Selected from C1-C4Alkyl；
R17、R18It is independently selected from hydrogen or C1-C4Alkyl；
R19Selected from following groups：P1、P2、P3、P5、P7、P8、P9、P12、P13、P14、P15、P16、P17、P19、P20、P21、P22、P23、P24、P25、P26、P27Or P28；
X is selected from O, S or NR17；
N is 0-2 integer.
4th, substituted cyanoacetate compound according to claim 3, it is characterised in that：In logical formula (I)
R1Selected from R6Or R7；
R2Selected from R8Or R9；
R3、R4、R5It is independently selected from CN, halogen or R17；
R6Selected from unsubstituted or substituted phenyl, described substituent is selected from 1-5 following radicals：Halogen, C1-C4Alkyl, C1-C4Haloalkyl；
R7Selected from unsubstituted or substituted fragrant heterocyclic radical, described substituent is selected from 1-3 following radicals：Halogen, C1-C4Alkyl, C1-C4Haloalkyl, described fragrant heterocyclic radical is selected from pyridine radicals, pyrimidine radicals, pyridazinyl, pyrazinyl, triazine radical, thienyl, thiazolyl, thiadiazolyl group, oxazolyl, isoxazolyls, furyl, pyrrole radicals, pyrazolyl, imidazole radicals, triazolyl or Isosorbide-5-Nitrae-oxygen thiapyran；
R8Selected from R6、R7、R10、R11、R12Or R13；
R9Selected from CHR14R15；
R10Selected from the R replaced with following groups16：R6Or R7；
R11Selected from the R replaced with following groups16：XR6Or XR7；
R12Selected from the R replaced with following groups16：C0OR6、COOR7、CONR6R12、CONR7R17、SO2NR6R17、SO2NR7R17、NHSO2R6Or NHSO2R7；
R13It is selected from：
R14Selected from CN or R17；
R15Selected from CN, COOR17、CONR17R18、CH2CH2OCH3, nonaromatic heterocycles base, or the C replaced by following groups1-C4Alkyl：CN、COOR17、CONR17R18、NR17R18、R19、OCH2CN、OCH2COOR16、OCH2CONR17R18、OCH2CF3、C3-C6Cycloalkyl oxy, C3-C6Cycloalkenyl oxy, C3-C6Non-aromatic heterocyclylalkyl epoxide, C3-C6Nonaromatic heterocycles alkenyl epoxide.Described nonaromatic heterocycles are selected from tetrahydrofuran, thiophane, nafoxidine, tetrahydro-thiazoles, tetrahydro-pyrazole, imidazolidine, tetrahydrochysene triazole, hexahydropyridine or hexahydro pyrans
R16Selected from C1-C4Alkyl；
R17、R18It is independently selected from hydrogen or C1-C4Alkyl；
R19Selected from following groups：P1、P2、P3、P5、P7、P8、P12、P14、P17、P19、P20、P21、P22、P23、P24、P25、P26、P27Or P28；
X is selected from O, S or NR17；
N is 0-2 integer.
5th, substituted cyanoacetate compound according to claim 4, it is characterised in that：In logical formula (I)
R1Selected from R6；
R2Selected from R8Or R9；
R3、R4、R5It is independently selected from CN, halogen or R17；
R6Selected from unsubstituted or substituted phenyl, described substituent is selected from 1-5 following radicals：Halogen, C1-C4Alkyl, C1-C4Haloalkyl；
R7Selected from unsubstituted or substituted fragrant heterocyclic radical, described substituent is selected from 1-3 following radicals：Halogen, C1-C4Alkyl, C1-C4Haloalkyl, described fragrant heterocyclic radical is selected from pyridine radicals, pyrimidine radicals, pyridazinyl, pyrazinyl, triazine radical, thienyl, thiazolyl, thiadiazolyl group, oxazolyl, isoxazolyls, furyl, pyrrole radicals, pyrazolyl, imidazole radicals, triazolyl or Isosorbide-5-Nitrae-oxygen thiapyran；
R8Selected from R6、R7、R10、R11、R12Or R13；
R9Selected from CHR14R15；
R10Selected from the R replaced with following groups16：R6Or R7；
R11Selected from the R replaced with following groups16：XR6Or XR7；
R12Selected from the R replaced with following groups16：COOR6、COOR7、CONR6R12、CONR7R17、SO2NR6R17、SO2NR7R17、NHSO2R6Or NHSO2R7；
R13It is selected from：
R14Selected from CN or R17；
R15Selected from CN, CH2CH2OCH3, nonaromatic heterocycles base or the C replaced by following groups1-C4Alkyl：CN、NR17R18、OCH2CN、OCH2CF3、C3-C6Cycloalkyl oxy, C3-C6Cycloalkenyl oxy, C3-C6Non-aromatic heterocyclylalkyl epoxide, C3-C6Nonaromatic heterocycles alkenyl epoxide；Described nonaromatic heterocycles base is selected from tetrahydrofuran, thiophane, nafoxidine, tetrahydro-thiazoles, tetrahydro-pyrazole, imidazolidine, tetrahydrochysene triazole, hexahydropyridine or hexahydro pyrans；
R16Selected from C1-C4Alkyl；
R17、R18It is independently selected from hydrogen or C1-C4Alkyl；
X is selected from O.
6th, a kind of logical formula (I) compound as claimed in claim 1 is harmful to mite class and its purposes of ovum in agricultural, pasture, lawn or indoor control.
7th, a kind of miticide composition, contains as claimed in claim 1 that logical formula (I) compound is as active component, and carrier and/or surfactant, and the weight content of active component is 0.01-99% in composition.
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| CN2008101167622A CN101628881B (en) | 2008-07-17 | 2008-07-17 | Substituted cyanoacetate compound and application thereof |
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| CN2008101167622A CN101628881B (en) | 2008-07-17 | 2008-07-17 | Substituted cyanoacetate compound and application thereof |
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| CN101628881A true CN101628881A (en) | 2010-01-20 |
| CN101628881B CN101628881B (en) | 2012-11-14 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110551148A (en) * | 2019-05-17 | 2019-12-10 | 华东理工大学 | compound containing silicon acyl acetonitrile, preparation method and application thereof |
| CN115974722A (en) * | 2022-12-28 | 2023-04-18 | 天津均凯农业科技有限公司 | Synthesis method of cyflumetofen |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3572483B2 (en) * | 2000-08-11 | 2004-10-06 | 大塚化学ホールディングス株式会社 | Acylacetonitrile compound, method for producing the same, and acaricide containing the compound |
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2008
- 2008-07-17 CN CN2008101167622A patent/CN101628881B/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110551148A (en) * | 2019-05-17 | 2019-12-10 | 华东理工大学 | compound containing silicon acyl acetonitrile, preparation method and application thereof |
| CN115974722A (en) * | 2022-12-28 | 2023-04-18 | 天津均凯农业科技有限公司 | Synthesis method of cyflumetofen |
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| CN101628881B (en) | 2012-11-14 |
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