CN101623444A - Chinese medicinal compound preparation for treating diabetic fatty liver - Google Patents

Abstract

The invention discloses a Chinese medicinal compound preparation for treating diabetic fatty liver, which uses eleven Chinese medicinal herbs as raw materials, including angelica, rhizoma atractylodis alba, radix bupleuri, radix codonopsitis, radix pseudostellariae, brassica alba boiss, coptis root, yam, corydalis tuber, dendrobe, and green tangerine orange peel. The Chinese medical compound preparation is developed by combining the modern latest achievements in scientific research on the basis of the traditional Chinese medical science dialectical therapy, has the efficacies of promoting blood circulation and removing obstruction in channels, strengthening the spleen and replenishing qi, clearing heat and detoxication, and soothing the liver and removing stagnation of food, has the advantages of outstanding curative effects, safety and convenience, and no toxic side effects, and is suitable for medicating diabetic fatty liver patients.

Description

A kind of compound Chinese medicinal preparation that is used for diabetic fatty liver

Technical field

The invention belongs to the Chinese medicine preparation technical field, relate to a kind of compound preparation, be specifically related to a kind of compound Chinese medicinal preparation that is used for diabetic fatty liver, and its preparation method is studied.

Technical background

The change with dietary structure of improving constantly along with people's living standard, popularizing of modern medicine serum biochemistry and ultrasound diagnosis, the sickness rate and the diagnosis of type ii diabetes and fatty liver day by day increase, the sickness rate that diabetes merge fatty liver also obviously increases, diabetic fatty liver also becomes in the fatty liver family the most common a kind of, accounts for 50%-60%.Fatty liver is the human body lipid metabolic disorder, and triacylglycerol is accumulated too much a kind of disease at liver.Discover that 15% patient can be changed hepatic fibrosis, liver cirrhosis into from simple fatty liver, even 3% patient can make progress and maybe needs to carry out Liver Transplantation for Treatment for liver failure.In recent years, abroad implemented in full the non-alcoholic fatty liver disease people has comprehensively been intervened, and domesticly still be in the cross-section survey stage, the interference method of all kinds of fatty livers or measure report are less, without ready patterns to follow, at a loss as to what to do, even in treatment, also there is some mistaken ideas, as quick weight-lossing, excessive dietary restriction, abuse fat-reducing and fat-reducing medicament etc., not only can not alleviate fatty liver, increase the danger of generation hepatic fibrosis on the contrary.

If the diagnosis of fatty liver is set up then how can be thought to be diabetic fatty liver on the diabetes basis.Diabetes and fatty liver are in close relations, and diabetes are one of non-alcoholic fatty liver disease causes of disease, and fatty liver is again one of complication of diabetes.For the type 2 diabetes mellitus patient, overweight people especially, itself is often with insulin resistant, disorders of lipid metabolism, so the mensuration of its dependency index does not have specificity to its concurrent fatty liver.

Over nearly 20 years, the Chinese medicine fatty liver has been obtained gratifying achievement.In order further to improve the clinical efficacy of Chinese medicine fatty liver, we help fortune treat on the empirical basis of fatty liver in the past with spleen invigorating, soothing the liver removing food stagnancy legislation prescription, and the treatment diabetic fatty liver is in the hope of obtaining better therapeutic effect.

Summary of the invention

The object of the invention is to provide a kind of compound Chinese medicinal preparation that is used for diabetic fatty liver, comprises its Chinese medicine composition of raw materials and preparation method.

Select Radix Angelicae Sinensis, Semen Sinapis Albae, Rhizoma Corydalis promoting blood circulation to remove obstruction in the collateral among this side for use, pain relieving; Radix Codonopsis, Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI; Rhizoma Coptidis, Herba Dendrobii heat-clearing and toxic substances removing; The herbal prescription of the soothing the liver removing food stagnancy of Pericarpium Citri Reticulatae Viride, all medicines share, and effect is concentrated one's efforts grand, the effect of playing promoting blood circulation to remove obstruction in the collateral, invigorating the spleen and benefiting QI, heat-clearing and toxic substances removing, soothing the liver removing food stagnancy altogether.

Be achieved through the following technical solutions order of the present invention:

1, the present invention is made by the following weight proportion raw material:

Radix Angelicae Sinensis 80～150g Rhizoma Atractylodis Macrocephalae 60～100g Radix Bupleuri 60～100g

Radix Codonopsis 30～80g Radix Pseudostellariae 20～60g Semen Sinapis Albae 60～100g

Rhizoma Coptidis 80～150g Rhizoma Dioscoreae 30～80g Rhizoma Corydalis 60～100g

Herba Dendrobii 60～100g Pericarpium Citri Reticulatae Viride 80～150g

2, each raw material weight proportioning of the best of the present invention's prescription is:

Radix Angelicae Sinensis 125g Rhizoma Atractylodis Macrocephalae 80g Radix Bupleuri 80g

Radix Codonopsis 65g Radix Pseudostellariae 45g Semen Sinapis Albae 80g

Rhizoma Coptidis 125g Rhizoma Dioscoreae 65g Rhizoma Corydalis 80g

Herba Dendrobii 80g Pericarpium Citri Reticulatae Viride 125g

3, preparation method:

(1) get the prescription item and descend each medical material pulverize separately or smash into coarse powder to pieces, standby;

(2) get Radix Bupleuri, Radix Codonopsis, Semen Sinapis Albae, each coarse powder mixing of Rhizoma Corydalis, add 4～8 times of water gagings of water earlier and decocted 1～2 hour; Add Radix Angelicae Sinensis, Rhizoma Coptidis, Herba Dendrobii, Pericarpium Citri Reticulatae Viride again and close and fry in shallow oil 2～3 hours, add suitable quantity of water simultaneously; Add the Rhizoma Atractylodis Macrocephalae, Radix Pseudostellariae, Rhizoma Dioscoreae at last and fried in shallow oil altogether 1～3 hour, put coldly, filter, collect filtrate, medicinal residues are standby;

(3) above-mentioned medicinal residues are added 6～8 times of water gagings, decocted 1～2 hour again, put coldly, filter, filtrate merges with the filtrate of (2), is concentrated into about 2000～3000ml, and is standby;

(4) 1. get above-mentioned concentrated solution, continue to be concentrated into water content and be about 5%～20%, the sterilization packing, sealing promptly gets extractum;

2. in above-mentioned concentrated solution, add the about 2～5g of sodium benzoate, stir evenly, the sterilization packing, sealing promptly gets decoction or mixture;

3. get above-mentioned concentrated solution, 70 ℃ are continued to be condensed into heat to survey relative density are 1.15～1.19 clear paste, and it is an amount of to add soluble starch, mixing, the low-temperature reduced-pressure drying is ground into fine powder, with 80% alcohol granulation of 2～3% steviosin, crosses 10～50 mesh sieves, packing, sealing promptly gets electuary.

A kind of compound Chinese medicinal preparation that is used for diabetic fatty liver of the present invention be by Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae etc. totally ten two the flavor Chinese herbal medicine be raw material, on the basis of traditional tcm syndrome differentiation and treatment, develop in conjunction with the latest modern technological scientific achievement.Effect with promoting blood circulation to remove obstruction in the collateral, invigorating the spleen and benefiting QI, heat-clearing and toxic substances removing, soothing the liver removing food stagnancy, has no side effect at determined curative effect, safe ready, is applicable to diabetic fatty liver patient's medication treatment.

The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.Following example is based on the above-mentioned subject area of the present invention, but is not limited to following example.

The specific embodiment

Embodiment 1: a kind of mixture that is used for diabetic fatty liver

Adopt following prescription:

Radix Angelicae Sinensis 125g Rhizoma Atractylodis Macrocephalae 80g Radix Bupleuri 80g

Radix Codonopsis 65g Radix Pseudostellariae 45g Semen Sinapis Albae 80g

Rhizoma Coptidis 125g Rhizoma Dioscoreae 65g Rhizoma Corydalis 80g

Herba Dendrobii 80g Pericarpium Citri Reticulatae Viride 125g

Preparation method:

(1) get the prescription item and descend each medical material pulverize separately or smash into coarse powder to pieces, standby;

(2) get Radix Bupleuri, Semen Sinapis Albae, each 80g of Rhizoma Corydalis, Radix Codonopsis 65g, each coarse powder mixes, and adds 6 times of water gagings of water earlier and decocts 2 hours; Add Radix Angelicae Sinensis, Rhizoma Coptidis, each 125g of Pericarpium Citri Reticulatae Viride again, Herba Dendrobii 80g closes and fries in shallow oil 2 hours, adds water simultaneously;

Add Rhizoma Atractylodis Macrocephalae 80g, Radix Pseudostellariae 45g at last, Rhizoma Dioscoreae 65g fried in shallow oil 2 hours altogether, put coldly, filtered, and collected filtrate, medicinal residues are standby;

(3) above-mentioned medicinal residues are added 6 times of water gagings, decocted 2 hours again, put coldly, filter, filtrate merges with the filtrate of (2), is concentrated into about 2500ml, and is standby;

(4) in above-mentioned concentrated solution, add the about 4g of sodium benzoate, stir evenly, the sterilization packing, sealing promptly gets mixture.

Embodiment 2: a kind of extractum that is used for diabetic fatty liver

Adopt following prescription:

Radix Angelicae Sinensis 80g Rhizoma Atractylodis Macrocephalae 60g Radix Bupleuri 60g

Radix Codonopsis 30g Radix Pseudostellariae 20g Semen Sinapis Albae 60g

Rhizoma Coptidis 80g Rhizoma Dioscoreae 30g Rhizoma Corydalis 60g

Herba Dendrobii 60g Pericarpium Citri Reticulatae Viride 80g

Preparation method:

(1) get the prescription item and descend each medical material pulverize separately or smash into coarse powder to pieces, standby;

(2) get Radix Bupleuri, Semen Sinapis Albae, each 60g of Rhizoma Corydalis, Radix Codonopsis 30g, each coarse powder mixes, and adds 4 times of water gagings of water earlier and decocts 1 hour; Add Radix Angelicae Sinensis, Rhizoma Coptidis, each 80g of Pericarpium Citri Reticulatae Viride again, Herba Dendrobii 60g closes and fries in shallow oil 2 hours, adds water simultaneously; Add Rhizoma Atractylodis Macrocephalae 60g, Radix Pseudostellariae 20g at last, Rhizoma Dioscoreae 30g fried in shallow oil 1 hour altogether, put coldly, filtered, and collected filtrate, medicinal residues are standby;

(3) above-mentioned medicinal residues are added 6 times of water gagings, decocted 1 hour again, put coldly, filter, filtrate merges with the filtrate of (2), is concentrated into about 2000ml, and is standby;

(4) get above-mentioned concentrated solution, continue to be concentrated into water content and be about 10%, the sterilization packing, sealing promptly gets extractum.

Embodiment 3: a kind of electuary that is used for diabetic fatty liver

Adopt following prescription:

Radix Angelicae Sinensis 150g Rhizoma Atractylodis Macrocephalae 100g Radix Bupleuri 100g

Radix Codonopsis 80g Radix Pseudostellariae 60g Semen Sinapis Albae 100g

Rhizoma Coptidis 150g Rhizoma Dioscoreae 80g Rhizoma Corydalis 100g

Herba Dendrobii 100g Pericarpium Citri Reticulatae Viride 150g

Preparation method:

(1) get the prescription item and descend each medical material pulverize separately or smash into coarse powder to pieces, standby;

(2) get Radix Bupleuri, Semen Sinapis Albae, each 100g of Rhizoma Corydalis, Radix Codonopsis 80g, each coarse powder mixes, and adds 8 times of water gagings of water earlier and decocts 2 hours; Add Radix Angelicae Sinensis, Rhizoma Coptidis, each 150g of Pericarpium Citri Reticulatae Viride again, Herba Dendrobii 100g closes and fries in shallow oil 3 hours, adds water simultaneously; Add Rhizoma Atractylodis Macrocephalae 100g, Radix Pseudostellariae 60g at last, Rhizoma Dioscoreae 80g fried in shallow oil 3 hours altogether, put coldly, filtered, and collected filtrate, medicinal residues are standby;

(3) above-mentioned medicinal residues are added 8 times of water gagings, decocted 2 hours again, put coldly, filter, filtrate merges with the filtrate of (2), is concentrated into about 3000ml, and is standby;

(4) get above-mentioned concentrated solution, 70 ℃ are continued to be condensed into heat to survey relative density are 1.16 clear paste, add the about 160g of soluble starch, mixing, the low-temperature reduced-pressure drying is ground into fine powder, with 80% alcohol granulation of 3% steviosin, crosses 24 mesh sieves, packing, sealing promptly gets electuary.

Claims (3)

1, a kind of compound Chinese medicinal preparation that is used for diabetic fatty liver is characterized in that it comprises that unit of weight is that raw material makes by the following Chinese medicine of g:

Radix Angelicae Sinensis 80～150g Rhizoma Atractylodis Macrocephalae 60～100g Radix Bupleuri 60～100g

Radix Codonopsis 30～80g Radix Pseudostellariae 20～60g Semen Sinapis Albae 60～100g

Rhizoma Coptidis 80～150g Rhizoma Dioscoreae 30～80g Rhizoma Corydalis 60～100g

Herba Dendrobii 60～100g Pericarpium Citri Reticulatae Viride 80～150g.

2, a kind of compound Chinese medicinal preparation that is used for diabetic fatty liver as claimed in claim 1 is characterized in that the weight g proportioning of each raw material is:

Radix Angelicae Sinensis 125g Rhizoma Atractylodis Macrocephalae 80g Radix Bupleuri 80g

Radix Codonopsis 65g Radix Pseudostellariae 45g Semen Sinapis Albae 80g

Rhizoma Coptidis 125g Rhizoma Dioscoreae 65g Rhizoma Corydalis 80g

Herba Dendrobii 80g Pericarpium Citri Reticulatae Viride 125g.

3, as the described a kind of compound Chinese medicinal preparation that is used for diabetic fatty liver of claim 1-2, it is characterized in that the preparation method of this compound Chinese medicinal preparation is:

(1) get the prescription item and descend each medical material pulverize separately or smash into coarse powder to pieces, standby;

(2) get Radix Bupleuri, Radix Codonopsis, Semen Sinapis Albae, each coarse powder mixing of Rhizoma Corydalis, add 4～8 times of water gagings of water earlier and decocted 1～2 hour;

Add Radix Angelicae Sinensis, Rhizoma Coptidis, Herba Dendrobii, Pericarpium Citri Reticulatae Viride again and close and fry in shallow oil 2～3 hours, add suitable quantity of water simultaneously; Add the Rhizoma Atractylodis Macrocephalae, Radix Pseudostellariae, Rhizoma Dioscoreae at last and fried in shallow oil altogether 1～3 hour, put coldly, filter, collect filtrate, medicinal residues are standby;

(3) above-mentioned medicinal residues are added 6～8 times of water gagings, decocted 1～2 hour again, put coldly, filter, filtrate merges with the filtrate of (2), is concentrated into about 2000～3000ml, and is standby;

(4) 1. get above-mentioned concentrated solution, continue to be concentrated into water content and be about 5%～20%, the sterilization packing, sealing promptly gets extractum;

2. in above-mentioned concentrated solution, add the about 2～5g of sodium benzoate, stir evenly, the sterilization packing, sealing promptly gets decoction or mixture;

3. get above-mentioned concentrated solution, 70 ℃ are continued to be condensed into heat to survey relative density are 1.15～1.19 clear paste, and it is an amount of to add soluble starch, mixing, the low-temperature reduced-pressure drying is ground into fine powder, with 80% alcohol granulation of 2～3% steviosin, crosses 10～50 mesh sieves, packing, sealing promptly gets electuary.