CN101618239B - Human body simulation circulating system - Google Patents
Human body simulation circulating system Download PDFInfo
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- CN101618239B CN101618239B CN200910055965XA CN200910055965A CN101618239B CN 101618239 B CN101618239 B CN 101618239B CN 200910055965X A CN200910055965X A CN 200910055965XA CN 200910055965 A CN200910055965 A CN 200910055965A CN 101618239 B CN101618239 B CN 101618239B
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- ventricular assist
- assist device
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Abstract
The invention relates to a human body simulation circulating system in the technical field of the detection of medical apparatuses, which comprises a heart simulating assembly, a heart control system, a sensing device, a data acquisition system, a peripheral simulating assembly, a cardiac ventricle auxiliary device and a controller, wherein the heart control system is connected with the heart simulating assembly; the heart simulating assembly and the peripheral simulating assembly are sequentially connected in series to form a heart simulating flow path system; the cardiac ventricle auxiliary device is connected in parallel with the heart simulating assembly to form a cardiac ventricle auxiliary flow path system; the sensing device is connected to a heart simulation and cardiac ventricle auxiliary combined flow path system; the input end of the data acquisition system is respectively connected with the sensing device and a computer to receive a pressure flux signal and a control command, and the output end of the data acquisition system is connected with the heart control system and the cardiac ventricle auxiliary device. The invention can detect the pressure and the flux of a plurality of positions in a flow path and is convenient for continuously optimizing the structure of the cardiac ventricle auxiliary device and a control system.
Description
Technical field
What the present invention relates to is the analog systems in a kind of medical apparatus and instruments detection technique field, specifically is a kind of ventricular assist device testing external performance that can be used for, and can produce the human body simulation circulating system of the liquid stream of beating.
Background technology
At present, ventricular assist device not only can be used as the transition bridge of heart transplantation, also is to lead to the purpose method that cardiac muscle recovers, the treatments that are applied to severe heart failure in latter stage at end more.But ventricular assist device will be applied to zoopery and clinical trial, must test its performance in in-vitro simulated blood circulation earlier, optimizes ventricular assist device structure and control system, to reduce zooperal time and cost.
Find through literature search prior art, " in-vitro simulated cardiovascular system hemodynamic performance is analyzed " of delivering on " biomedical engineering's magazine " (2006 the 23rd volume the 4th phase 778-780 pages or leaves) mentioned a kind of in-vitro simulated circulation experiment platform, this laboratory table is based on the single elastic cavity model construction of three element, be mainly used in the performance of test axial blood pump, comprise rotating speed, parameters such as pressure in the closed circuit and flow, but this laboratory table does not make up closed loop to the control of blood pump, the signal of gathering is not used to realize feedback control to blood pump, natural heartthrob state is not simulated simultaneously, so can not reflect influencing each other between heart simulated assembly and the blood pump.
Find by retrieval again, a kind of medical experiment system that can monitor artificial heart blood pump duty in real time is provided in the patent document of Chinese patent publication number CN101380490A, carry in this system and the above-mentioned document and in-vitro simulated circulation experiment platform structure basic identical, the main difference part is to have added the temperature test to blood pump, and all detected flows, temperature, pressure signal be simultaneously displayed on the PC by data acquisition unit, but this system is the same with aforementioned means, also natural heartthrob state is not simulated.
A kind of system that is used for artificial heart is carried out in-vitro simulated loop test is provided in the patent document of Chinese patent publication number CN1846605A, this system constructing body circulation and pulmonary circulation model, can characterize the dynamic response characteristic of human body artery blood vessel, system can adjust according to the physiological parameter of initial selected, the test physiological environment possessed certain adaptability, but this system only is applicable to total artificial heart is tested, do not consider the state of nature heart, can not test ventricular assist device simultaneously.
Summary of the invention
The present invention is directed to the prior art above shortcomings, a kind of human body simulation circulating system is provided, made up the associating flow path system of heart simulated assembly and ventricular assist device, and can monitor and control duty and its interaction of heart simulated assembly, ventricular assist device.
The present invention is achieved by the following technical solutions, the present invention includes: heart simulated assembly, heart control system, sensing device, data collecting system, periphery simulated assembly and ventricular assist device, wherein: the heart control system is connected with the heart simulated assembly, heart simulated assembly and periphery simulated assembly are composed in series heart simulation flow path system successively, and ventricular assist device and heart simulated assembly compose in parallel the auxiliary flow path system of ventricle.Sensing device is connected in heart simulation and the auxiliary associating flow path system of ventricle, the input of data collecting system is connected with computer to receive pressure flow signal and control instruction with sensing device respectively, and the outfan of data collecting system is connected with ventricular assist device with the heart control system.
Described heart simulated assembly comprises: liquid capsule, air bag, first check valve and second check valve, wherein: air bag and liquid capsule bonding are fixing, air bag is connected with the heart control system through trachea, and the liquid capsule is connected with ventricular assist device with first check valve, second check valve, periphery simulated assembly respectively through the liquid pipe.
Described first check valve and second check valve are used to simulate atrioventricular valves (A V valves) and arterial valve.
The total 3 place's tubular openings that are provided with in the sidewall of described liquid capsule and bottom, wherein: the two place's tubular openings that are positioned at sidewall are connected with second check valve with first check valve respectively, the tubular opening that is positioned at the bottom is connected with ventricular assist device, and this liquid capsule is used to simulate left ventricle.
The sidewall of described air bag is provided with 2 place's tubular openings and is connected with the heart control system through air inlet pipe respectively, and the bottom of air bag is provided with circular hole, and the tubular opening of liquid capsule bottom is passed through, and air bag is bonded and sealed with the liquid capsule respectively in the upper limb and the bottom of sidewall.
Described liquid capsule and air bag are hollow hemisphere shape structure, adopt medical polyurethane material to make.
Described ventricular assist device comprises: blood pump, controller, hand switch valve, the 3rd check valve and the 4th check valve, wherein: the two ends of hand switch valve are connected with blood pump with the liquid capsule respectively, the 3rd check valve and the 4th check valve are connected to the import and the exit position of blood pump, and controller is connected with data collecting system with blood pump respectively.
Described blood pump is pulsation type blood pump or non-pulsation type blood pump.
Described periphery simulated assembly comprises: elastic cavity, orifice valve and blood vessel, wherein: the input of elastic cavity is connected with the exit of heart simulated assembly and ventricular assist device respectively through the liquid pipe, the outfan of elastic cavity connects an end of orifice valve, and the other end of orifice valve is connected through the porch of blood vessel with the heart simulated assembly.
Described orifice valve is used to simulate the Peripheral resistance of whole circulation system, and described blood vessel is used to simulate left atrium.
Described elastic cavity is used to simulate the compliance of tremulous pulse, this elastic cavity is a cylinder-like structure, the both sides, lower end of elastic cavity are provided with 2 tubular openings, the inside of elastic cavity is provided with spring and sealing slide block, wherein: both ends of the spring is connected to the center, upper end of elastic cavity and the center of sealing slide block, slides in the elastic cavity setting and elastic cavity is divided into two chambers of sealing slide block.
Described sensing device comprises: piezometer, effusion meter and barometer, wherein: some piezometers are arranged at the exit, lower end of heart simulated assembly respectively, heart simulated assembly and ventricular assist device outlet meet with the elastic cavity exit, some effusion meters are arranged at heart simulated assembly exit respectively, the ventricular assist device exit, the heart simulated assembly is connected meet with ventricular assist device, the outfan of piezometer and effusion meter all is connected to data collecting system, barometer is installed between heart simulated assembly and the heart control system, is used to monitor the power that the heart simulated assembly is beaten.
Described heart control system comprises: air compressor, vacuum pump, electromagnetic valve, electric Proportion valve and manual modulation valve, wherein: air compressor connects electric Proportion valve through trachea and constitutes the air inlet gas circuit, vacuum pump connects manual modulation valve and electromagnetic valve successively through trachea and constitutes the gas circuit of bleeding, the air inlet gas circuit and the gas circuit of bleeding are connected to air bag through barometer, and electromagnetic valve all is connected with data collecting system to receive control instruction with electric Proportion valve.
Heart simulated assembly of the present invention is connected with ventricular assist device, periphery simulated assembly by the liquid pipe, the blood circulation stream of simulation whole circulation system.With the contraction and the diastole of heart control system realization heart simulated assembly, with the auxiliary pump blood of ventricular assist device controller control ventricle state.Sensing device is with flow and pressure signal is transferred to data collecting system and computer is handled, realization is to the real-time demonstration of ventricular assist device performance parameter, and the output control instruction is to heart control system and ventricular assist device controller, to realize the closed loop control of whole simulation circulating system.
Compared with prior art, the present invention has good adaptability, by control to gas circuit, in anthropomorphic dummy's systemic circulatory system, simulate different ventricular pressures, ventricular beat cycle, arterial pressure, blood flow etc., therefore can simulate heart failure in various degree, realization is convenient to realize continuing to optimize ventricular assist device structure and control system to the performance test of various parallel ventricular assist devices (displacement pump, axial-flow pump, centrifugal pump).
Description of drawings
Fig. 1 is a system structure sketch map of the present invention.
Fig. 2 is a heart control system sketch map.
The specific embodiment
Below embodiments of the invention are elaborated, present embodiment is being to implement under the prerequisite with the technical solution of the present invention, provided detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.
As shown in Figure 1, this example comprises: heart simulated assembly 1, ventricular assist device 2, sensing device 3, data collecting system 4, periphery simulated assembly 5 and heart control system 6, wherein: heart control system 6 is connected with heart simulated assembly 1, heart simulated assembly 1 is serially connected in heart simulation flow path system with periphery simulated assembly 5, and ventricular assist device 2 composes in parallel the auxiliary flow path system of ventricle with heart simulated assembly 1.Sensing device 3 is connected in heart simulation and the auxiliary associating stream of ventricle, the input of data collecting system 4 is connected with computer to receive pressure flow signal and control instruction with sensing device 3 respectively, and the outfan of data collecting system 4 is connected with computer with heart control system 6, ventricular assist device 2.
Described heart simulated assembly 1 comprises: liquid capsule 7, air bag 8, first check valve 9 and second check valve 10, wherein: air bag 8 is bonded and sealed with liquid capsule 7 respectively in the upper limb and the bottom of sidewall, air bag 8 is connected with heart control system 6 through trachea 25 respectively, liquid capsule 7 has 3 tubular openings, be respectively liquid stream import 11, liquid stream outlet 12 and bottom liquid stream outlet 13, liquid stream import 11 and liquid stream outlet 12 is connected with second check valve 10 with first check valve 9 respectively through liquid pipe 24, be connected with periphery simulated assembly 5 then, the bottom liquid stream outlet is connected with ventricular assist device 2 through liquid pipe 24.
Described liquid capsule 7 and air bag 8 are hollow hemisphere shape structure, adopt medical polyurethane material to make.
Described ventricular assist device 2 comprises: blood pump 14, controller 15, the 3rd check valve 16, the 4th check valve 17 and hand switch valve 18, wherein: manually check valve 18 is connected between heart simulated assembly 1 bottom liquid stream outlet the 13 and the 3rd check valve 16, the 3rd check valve 16 and the 4th check valve 17 are connected to blood pump 14 and import and export the position, blood pump 14 is pulsation type blood pumps, and controller 15 is connected with data collecting system 4 with blood pump 14 respectively.
Described periphery simulated assembly 5 comprises: elastic cavity 19, orifice valve 20 and blood vessel 21, wherein: the input of elastic cavity 19 through liquid pipe 24 respectively with heart simulated assembly 1 in check valve 10 be connected with the 4th check valve 17 in the ventricular assist device 2, the outfan of blood vessel 21 is connected with liquid stream import 11 in the liquid capsule 7 through liquid pipe 24, and the outfan of the input of blood vessel 21 and elastic cavity 19 is connected orifice valve 20 by liquid pipe 24.
Described elastic cavity 19 is a cylinder-like structure, there are 2 tubular openings the both sides, lower end, there are a spring 22 and sealing slide block 23 in elastic cavity 19 inside, spring 22 two ends are connected to center, elastic cavity 19 upper end and sealing slide block 23 centers, sealing slide block 23 is divided into two chambers with elastic cavity 19, and sealing slide block 23 simultaneously can slide up and down in elastic cavity 19.
Described sensing device 3 comprises: barometer 31, piezometer 32 and effusion meter 33, wherein: barometer 31 is installed between heart simulated assembly 1 and the heart control system 6, is used to monitor the power that heart simulated assembly 1 is beaten.Some piezometers 32 be arranged at respectively heart simulated assembly 1 bottom liquid stream export the outlet 12 of 13 places, heart simulated assembly 1 liquid stream and ventricular assist device 2 outlet meets with elastic cavity 19 exit positions, some effusion meters 33 are arranged at check valve 10 exit positions in the heart simulated assembly 1, ventricular assist device 2 exit positions, heart simulated assembly 1 respectively and are connected meet with ventricular assist device 2, and the outfan of piezometer 32 and effusion meter 33 is connected to data collecting system 4 respectively.
As shown in Figure 2, described heart control system 6 comprises: air compressor 26, vacuum pump 27, manual modulation valve 28, electromagnetic valve 29 and electric Proportion valve 30, and wherein: air compressor 26 connects electric Proportion valve 30 through trachea 25 and forms the air inlet gas circuit; Vacuum pump 27 connects manual modulation valve 28, electromagnetic valve 29 successively through trachea 25 and forms the gas circuit of bleeding.The air inlet gas circuit and the gas circuit of bleeding are connected to air bag 8 through barometer 31 other ends, and data collecting system 4 is connected with electric Proportion valve 30 with the transmission control instruction with electromagnetic valve 29.
The detailed operation process of present embodiment is as follows:
When hand switch valve 18 cuts out, make 1 work of heart simulated assembly by computer and data collecting system 4, ventricular assist device 2 is not worked, and promptly system has only the work of heart simulation stream.Open air compressor 26 and vacuum pump 27, data collecting system 4 transmission of control signals are to heart control system 6, the switch of control electromagnetic valve 29 and the aperture of electric Proportion valve 30, the control signal of electromagnetic valve 29 and electric Proportion valve 30 realizes interlocking, be that electric Proportion valve 30 is when opening, electromagnetic valve 29 cuts out, and this moment, air compressor 26 was inflated to air bag 8, realized the contraction of liquid capsule 7; When electric Proportion valve 30 was closed, electromagnetic valve 29 was opened, and this moment, vacuum pump 27 was bled to air bag 8, realized the diastole of liquid capsule 7.The contraction of liquid capsule 7 and diastole promptly realize the blood-pumping function of heart simulated assembly 1, liquid in the system flows out via liquid capsule 7 liquid stream outlet 12, flow through successively check valve 10, elastic cavity 19, orifice valve 20, blood vessel 21, check valve 9 flow back in the liquid capsule 7 through liquid stream import 11 at last.The signal that piezometer 32 and effusion meter 33 are gathered in the stream is transferred to data collecting system 4, to realize the closed loop control of flow path pressure and flow.By the aperture of adjusting electric Proportion valve 30 and the switch time of electromagnetic valve 29, simulate the heart heart failure in various degree of beating.
When hand switch valve 18 is opened, by computer and data collecting system 4 heart simulated assembly 1 and ventricular assist device 2 are worked simultaneously, can test the performance of ventricular assist device 2 under heart failure state in various degree this moment.Heart simulation this moment stream work process is identical when closing with hand switch valve 18, the work process of the auxiliary stream of ventricle is as follows: data collecting system 4 transmission of control signals make blood pump 14 work for ventricular assist device controller 15, under the effect of blood pump 14, liquid in the loop is through the bottom liquid stream of liquid capsule 7 outlet 13 flow through hand switch valve 18, check valve 17, blood pump 14, check valve 18, elastic cavity 19, orifice valve 20, blood vessel 21, check valve 9, after liquid stream import 11 flow back in the liquid capsule 7.The signal that piezometer 32 and effusion meter 33 are gathered in the stream is transferred to data collecting system 4 and computer, demonstrate performance parameters such as the pressure of ventricular assist device 2 and flow in real time, 4 pairs of data of data collecting system are handled the back feedback control signal and are given ventricular assist device controller 15 simultaneously, realize the closed loop control to ventricular assist device 2.
Claims (6)
1. human body simulation circulating system, it is characterized in that, comprise: the heart simulated assembly, the heart control system, sensing device, data collecting system, periphery simulated assembly and ventricular assist device, wherein: the heart control system is connected with the heart simulated assembly, heart simulated assembly and periphery simulated assembly are composed in series heart simulation flow path system successively, ventricular assist device and heart simulated assembly compose in parallel the auxiliary flow path system of ventricle, sensing device is connected in heart simulation and the auxiliary associating flow path system of ventricle, the input of data collecting system is connected with computer to receive pressure with sensing device respectively, flow signal and control instruction, the outfan of data collecting system is connected with ventricular assist device with the heart control system;
Described heart simulated assembly comprises: liquid capsule, air bag, first check valve and second check valve, wherein: air bag and liquid capsule bonding are fixing, air bag is connected with the heart control system through trachea, and the liquid capsule is connected with ventricular assist device with first check valve, second check valve, periphery simulated assembly respectively through the liquid pipe;
Described periphery simulated assembly comprises: elastic cavity, orifice valve and blood vessel, wherein: the input of elastic cavity is connected with the exit of heart simulated assembly and ventricular assist device respectively through the liquid pipe, the outfan of elastic cavity connects an end of orifice valve, and the other end of orifice valve is connected through the porch of blood vessel with the heart simulated assembly;
Described heart control system comprises: air compressor, vacuum pump, electromagnetic valve, electric Proportion valve and manual modulation valve, wherein: air compressor connects electric Proportion valve through trachea and constitutes the air inlet gas circuit, vacuum pump connects manual modulation valve and electromagnetic valve successively through trachea and constitutes the gas circuit of bleeding, the air inlet gas circuit and the gas circuit of bleeding are connected to air bag through barometer, and electromagnetic valve all is connected with data collecting system to receive control instruction with electric Proportion valve.
2. human body simulation circulating system according to claim 1, it is characterized in that, the total 3 place's tubular openings that are provided with in the sidewall of described liquid capsule and bottom, wherein: the two place's tubular openings that are positioned at sidewall are connected with second check valve with first check valve respectively, the tubular opening that is positioned at the bottom is connected with ventricular assist device, and this liquid capsule is used to simulate left ventricle.
3. human body simulation circulating system according to claim 1 is characterized in that, the sidewall of described air bag is provided with 2 place's tubular openings and is connected with the heart control system through air inlet pipe respectively, and the bottom of air bag is provided with circular hole, and the tubular opening of liquid capsule bottom is passed through.
4. human body simulation circulating system according to claim 1, it is characterized in that, described ventricular assist device comprises: blood pump, controller, hand switch valve, the 3rd check valve and the 4th check valve, wherein: the two ends of hand switch valve are connected with blood pump with the liquid capsule respectively, the 3rd check valve and the 4th check valve are connected to the import and the exit position of blood pump, and controller is connected with data collecting system with blood pump respectively.
5. human body simulation circulating system according to claim 1, it is characterized in that, described elastic cavity is a cylinder-like structure, the both sides, lower end of elastic cavity are provided with 2 tubular openings, the inside of elastic cavity is provided with spring and sealing slide block, wherein: both ends of the spring is connected to the center, upper end of elastic cavity and the center of sealing slide block, slides in the elastic cavity setting and elastic cavity is divided into two chambers of sealing slide block.
6. human body simulation circulating system according to claim 1, it is characterized in that, described sensing device comprises: piezometer, effusion meter and barometer, wherein: some piezometers are arranged at the exit, lower end of heart simulated assembly respectively, heart simulated assembly and ventricular assist device outlet meet and elastic cavity exit, some effusion meters are arranged at heart simulated assembly exit respectively, the ventricular assist device exit, the heart simulated assembly is connected meet with ventricular assist device, the outfan of piezometer and effusion meter all is connected to data collecting system, barometer is installed between heart simulated assembly and the heart control system, is used to monitor the power that the heart simulated assembly is beaten.
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| CN200910055965XA CN101618239B (en) | 2009-08-06 | 2009-08-06 | Human body simulation circulating system |
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