CN101618217B - Method for coating gastralgia tablets - Google Patents
Method for coating gastralgia tablets Download PDFInfo
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- CN101618217B CN101618217B CN2009100655303A CN200910065530A CN101618217B CN 101618217 B CN101618217 B CN 101618217B CN 2009100655303 A CN2009100655303 A CN 2009100655303A CN 200910065530 A CN200910065530 A CN 200910065530A CN 101618217 B CN101618217 B CN 101618217B
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Abstract
The invention relates to the preparation technology of medicines and mainly provides a method for coating gastralgia tablets. In the method for coating gastralgia tablets, the coating powder for coating the gastralgia tablets comprises the following ingredients in the mass percent: 30-40 of hydroxypropyl methylcellulose, 8-12 of PEG-600, 15-25 of S-630, 2-5 of silicon powder, 10-15 of talcum powder and 15-25 of iron oxide red. The method for coating gastralgia tablets comprises the following steps: directly mixing the powdered ingredients according to the proportion; adding water the amount of which is 6 times of that of the mixture and being milled for two times by an emulsifying colloid mill to prepare uniform emulsion; and then, coating the tablets by a spraying film coating method. Each coated film tablet has uniform color on the surface, has regular edges, has strong toughness and can achieve the requirements. The purposes of water resistance and cracking prevention can be achieved by an accelerating test.
Description
Technical field
The present invention relates to preparation technology of medicine, mainly propose a kind of coating method of gastralgia tablet.
Background technology
Gastralgia tablet is by Endoconcha Sepiae, Rhizoma Corydalis, and alumen ustum three flavor medicines are formed, and the product abnormal flavour is heavier, must coating.And these three kinds of composition hygroscopicity are extremely strong, and general coating mode can not be avoided its moisture absorption.Can expand again after the tablet moisture absorption, and the clothing of conventional method bag does not have toughness, so the very fast sliver that causes again.
Summary of the invention
The objective of the invention is to propose a kind of coating method of gastralgia tablet.
In the coating method proposed by the invention, be in order to its composition of coating powder and the mass percent that coats described gastralgia tablet:
Hydroxypropyl emthylcellulose: 30-40%
PEG-600 8-12％
S-630 15-25％
Silica flour 2-5%
Pulvis Talci 10-15%
Iron oxide red 15-25%
Be pulverous composition more than inciting somebody to action, after directly mixing in proportion, (the emulsifying colloid mill is a kind of equipment that powder can be dispersed in the solvent to add 6 times of amounts of water Over emulsfication colloid mill, it is thinner that it can grind the solute in the solution, make at the solution that forms more stable, even) grind twice, make uniform emulsion, carry out the tablet coating operation with spraying film coating method.
Hydroxypropyl emthylcellulose is just to be used for film-coated new material in recent years, it to light, heat, wetly all have stability, filming performance is good, film is transparent, tough and tensile, coating does not have the bonding phenomenon, and safety non-toxic.It can prevent the moisture absorption characteristic of gastralgia tablet effectively, prevents sliver, extend the shelf life, and in proportioning main film former.
When film former uses separately, film-formation result can not satisfy the requirement of preparation coating, the film-coat bad mechanical strength that contracts out, add S-630 (copolyvidone) and PEG-600 (Macrogol 600), improve the mechanical strength of film-coat, improve the mechanical performance of film-coat, make film-coat be in best state the adhesion of label.
Because the color of general Chinese medicine label is generally darker, and color and luster is inhomogeneous, adds silica flour, Pulvis Talci, iron oxide red and constitute screening agent for three kinds in the process of coating, makes any surface finish of sheet, the color homogeneous, and the contained readily oxidizable substance of label had the antioxidative effect.
Coating method proposed by the invention, the product water-resisting property behind the coating is very strong, and can sliver.Solved the difficult problem of coating of gastralgia tablet.
The specific embodiment
Embodiment 1
The coating powder that coats gastralgia tablet adopts following compositions and proportioning:
Hydroxypropyl emthylcellulose: 30%
PEG-600 8％
S-630 25％
Silica flour 2%
Pulvis Talci 15%
Iron oxide red 20%
Will more than be pulverous composition, after directly mixing in proportion, add 6 times of amounts of water Over emulsfication colloid mill mill twice, make uniform emulsion, carry out tablet coating with the film coating method of spraying and operate.The Film coated tablets surface color that contracts out is even, neat in edge, and film-coat toughness is very strong, can reach requirement.Can reach water proof through accelerated test, prevent the purpose of sliver.
Embodiment 2
The coating powder that coats gastralgia tablet adopts following compositions and proportioning:
Hydroxypropyl emthylcellulose: 40%
PEG-600 10％
S-630 20％
Silica flour 5%
Pulvis Talci 10%
Iron oxide red 15%
Will more than be pulverous composition, after directly mixing in proportion, add 6 times of amounts of water Over emulsfication colloid mill mill twice, make uniform emulsion, carry out tablet coating with the film coating method of spraying and operate.The Film coated tablets surface color that contracts out is even, neat in edge, and film-coat toughness is very strong, can reach requirement.Can reach water proof through accelerated test, prevent the purpose of sliver.
Embodiment 3
The coating powder that coats gastralgia tablet adopts following compositions and proportioning:
Hydroxypropyl emthylcellulose: 35%
PEG-600 10％
S-630 25％
Silica flour 3%
Pulvis Talci 12%
Iron oxide red 15%
Will more than be pulverous composition, after directly mixing in proportion, add 6 times of amounts of water Over emulsfication colloid mill mill twice, make uniform emulsion, carry out tablet coating with the film coating method of spraying and operate.The Film coated tablets surface color that contracts out is even, neat in edge, and film-coat toughness is very strong, can reach requirement.Can reach water proof through accelerated test, prevent the purpose of sliver.
Embodiment 4
The coating powder that coats gastralgia tablet adopts following compositions and proportioning:
Hydroxypropyl emthylcellulose: 35%
PEG-600 12％
S-630 15％
Silica flour 3%
Pulvis Talci 10%
Iron oxide red 25%
Will more than be pulverous composition, after directly mixing in proportion, add 6 times of amounts of water Over emulsfication colloid mill mill twice, make uniform emulsion, carry out tablet coating with the film coating method of spraying and operate.The Film coated tablets surface color that contracts out is even, neat in edge, and film-coat toughness is very strong, can reach requirement.Can reach water proof through accelerated test, prevent the purpose of sliver.
Claims (1)
1. the coating method of a gastralgia tablet, the gastralgia tablet in the described coating method is made up of Endoconcha Sepiae, Rhizoma Corydalis, alumen ustum three flavor medicines; It is characterized in that: be in order to its composition of coating powder and the mass percent that coats described gastralgia tablet:
Will more than be pulverous composition, after directly mixing in proportion, add 6 times of amounts of water Over emulsfication colloid mill mill twice, make uniform emulsion, carry out tablet coating with the film coating method of spraying and operate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100655303A CN101618217B (en) | 2009-07-27 | 2009-07-27 | Method for coating gastralgia tablets |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100655303A CN101618217B (en) | 2009-07-27 | 2009-07-27 | Method for coating gastralgia tablets |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101618217A CN101618217A (en) | 2010-01-06 |
| CN101618217B true CN101618217B (en) | 2011-12-28 |
Family
ID=41511745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009100655303A Active CN101618217B (en) | 2009-07-27 | 2009-07-27 | Method for coating gastralgia tablets |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101618217B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103505517B (en) * | 2013-10-10 | 2015-11-25 | 李彦良 | A kind of preparation method of gastralgia tablet and application |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001003698A1 (en) * | 1999-07-09 | 2001-01-18 | Ortho-Mcneil Pharmaceutical, Inc. | Taste masked pharmaceutical liquid formulations |
| CN1307873A (en) * | 2000-03-20 | 2001-08-15 | 叶耀良 | Coated Gongyanping tablet in special shape and its making process |
| CN1966032A (en) * | 2005-11-17 | 2007-05-23 | 大连天山药业有限公司 | Tablet with seven kinds of ingredients for treating stomach ache and preparation process thereof |
-
2009
- 2009-07-27 CN CN2009100655303A patent/CN101618217B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001003698A1 (en) * | 1999-07-09 | 2001-01-18 | Ortho-Mcneil Pharmaceutical, Inc. | Taste masked pharmaceutical liquid formulations |
| CN1307873A (en) * | 2000-03-20 | 2001-08-15 | 叶耀良 | Coated Gongyanping tablet in special shape and its making process |
| CN1966032A (en) * | 2005-11-17 | 2007-05-23 | 大连天山药业有限公司 | Tablet with seven kinds of ingredients for treating stomach ache and preparation process thereof |
Non-Patent Citations (1)
| Title |
|---|
| 张莉，等.胃痛宁的药理研究.《重庆中草药研究》.1999,(第39期), * |
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| Publication number | Publication date |
|---|---|
| CN101618217A (en) | 2010-01-06 |
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