CN101596278A - The pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes - Google Patents

Abstract

A kind of pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes, said composition comprises Radix Ophiopogonis, Rhizoma Polygonati, compound vitamin B, vitamin E and trace element zinc, selenium, chromium, copper, molybdenum, iodine, manganese, mainly be applicable to hyperglycemia, hyperlipidemia and diabetic population, very effective aspect blood sugar lowering and blood fat and treatment diabetes, but chronic administration or use by the course of treatment.

Description

The pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes

Technical field:

The present invention relates to the Medicines and Health Product technical field; Pharmaceutical composition in particular for blood sugar lowering and blood fat and treatment diabetes.

Background technology:

Said composition comprises Radix Ophiopogonis, Rhizoma Polygonati, compound vitamin B, vitamin E and trace element zinc, selenium, chromium, copper, molybdenum, iodine, manganese.

Be a kind ofly can nourishing lung-YIN be arranged, reinforcing stomach reg fluid, the relieving restlessness that clears away heart-fire, the effect of loosening bowel to relieve constipation as the nourishing YIN class natural Chinese medicine of health food Radix Ophiopogonis; Cure mainly deficiency of YIN chronic cough, interior-heat is quenched one's thirst, vexed insomnia, diseases such as dryness of the intestine constipation; Modern pharmacological research confirms to have Radix Ophiopogonis: 1, hypoglycemic activity 2, improve myocardial contraction and heart pump function; 3, the effect of protection cardiac muscle; 4, oxygen lack resistant function; 5, remove the free radical effect; 6, anti-aging effects; 7, enhance immunity effect; 8, Antishock function; 9, accelerate the intestinal progradation; 10, antibacterial action etc.

Rhizoma Polygonati be a kind of be food be again the deficiency tonifying kind natural Chinese medicine of medicine, have the lung moistening YIN nourishing, the effect of invigorating the spleen and replenishing QI; Be mainly used in deficiency of the lung cough caused by dryness, the chronic cough hemoptysis, essence and blood loses empty, and interior-heat is quenched one's thirst, insufficiency of the spleen asthenia, the xerostomia lack of appetite is hard and dry etc.; Doctor trained in Western medicine is examined to chronic bronchitis, bronchiectasis, pulmonary carcinoma, recurrent respiratory tract infection, cough during pregnancy, pertussis belong to deficiency of lung-YIN person, and diabetes spp is in lung-stomach yin deficiency card person; Modern pharmacological research confirms that Rhizoma Polygonati has: 1, significantly reduce serum cholesterol and triglyceride content, obviously alleviate aorta wall speckle and coronary atherosclerosis; 2, obviously reduce the lipofuscin amount of cardiac muscle, improve the liver SOD activity, protection free-radical induced lipid peroxidation and biomembrane damage; 3, the effect of enhancing human body immunity function; 4, obviously resist the effect that peripheral blood cells reduces; 5, hypoglycemic activity; 6, effects such as defying age, resisting fatigue, hemostasis, cohesion cancerous cell.

Vitamin B group participates in body internal protein, fat and sugar metabolism, makes the excitement of brain cell and inhibition be in poised state, and it comprises vitamin B ₁, vitamin B ₂, nicotiamide, pantothenic acid, biotin, vitamin B ₆, vitamin B ₁₂, folic acid etc., collaborative in vivo performance physiological action.Vitamin B ₁Participate in body internal protein, fat, breakdown of carbohydrates metabolism and anabolism, can show vitamin B1 deficiency during shortage is the various dysbolismus of representative, vitamin B in addition ₁Also participate in the neural impulse reaction, keep myocardium normal function, keep normal appetite, gastrointestinal peristalsis and digestive juice secretion etc.; Vitamin B ₂Have another name called riboflavin, it is the ingredient of many important coenzyme in the body, participate in intravital substance metabolism, guarantee that vivo oxidation reduction reaction and energy generate, participate in anti-oxidative defense system in the body, mainly show oral cavity reproductive system syndrome, retardation of growth, iron deficiency anemia, moisture dermatitis, minimizing erythropoiesis, the systemic-function that affects the nerves, the vision etc. that reduces during shortage; Nicotiamide claims niacin amide or vitamin PP again, and its physiological function is to participate in the body intracellular metabolic, keeps normal neurological function, and pellagra can take place during shortage in synthesizing of assurance gonadal hormone etc., mainly shows as dermatitis, diarrhoea, dull-witted three big symptoms; Pantothenic acid extensively exists in each organism, participates in metabolic activity widely, and known have 70 plurality of enzymes all to need pantothenic acid to participate in all kinds of biochemical reaction of catalysis body, otherwise just can Metabolic disorder; Biotin also is a kind of vitamin B group, coordinates to participate in the metabolism of human body matter and energy with other vitamin B group, and it is synthetic with nucleic acid, and the compositive relation of gonadal hormone is close, and it also has control poliosis, bareheaded effect; Vitamin B ₆Play the coenzyme effect of transaminase, amino acid decarboxylases in vivo, guarantee the metabolism of materials such as aminoacid, glycogen, fatty acid and one carbon unit, nicotinic acid, guarantee the normal propagation of nucleic acid and proteinic synthetic and cell, guarantee homergy with neurotransmitteies such as a hydroxytryptamine, taurine, dopamine, guarantee normal immunologic function, immunity degradation during shortage also can cause neural infringement; Vitamin B ₁₂Participate in nucleic acid in vivo, choline, amino acid whose synthetic and fat and sugared metabolism, to hemopoietic function of bone marrow, the gastrointestinal epithelial cells function, liver function and nervous system myelin functional integrity have certain effect, it is the necessary vitamin of intelligence of bringing into normal play, not only cause dysnoesia if lack, also nutritional anemia can occur, influence is to blood supply in the brain; Folic acid participates in the synthetic of aminoacid and nucleic acid, and and vitamin B ₁₂The common generation that promotes cell is with ripe, and normal cell can not carry out mitosis during shortage, the neurological symptom can occur, as: the loss of memory, depression and dementia etc.;

Vitamin E is all general designations with the bioactive chromone derivative of alpha-tocopherol, and wherein the activity of alpha-tocopherol is the highest, has antioxidation, avoids the effect of biomembrane generation lipid peroxidation; Stop the effect of LDL oxidation formation, thereby prevent the generation of atherosclerosis and cardiovascular disease; Also have to regulate immunity, slow down aging, inhibition tumor in addition, promote fetal development and reproductive performance to reach the protective effect of nerve and skeleton etc.

Trace element zinc is merged in the biomacromolecule ligand---in protein, nucleic acid, the film (being mainly memebrane protein), generate stable metallic biomacromolecule complex---metalloprotein, metalloproteinase nucleic acid complex etc., at present, known these materials participate in the synthetic and degradation process of carbohydrate, lipid, protein and nucleic acid, and the existence of zinc enzyme is all arranged in six big fermentoids; Zinc also is the essential element of enhance immunity vigor; Zinc can promote that proinsulin is converted into insulin by activating protaminase, and zinc deficiency makes insulin be obstructed in the activity of peripheral tissues, and it is unusual to cause glucose tolerance curve.

Trace element-selenium has obvious reduction serum total cholesterol, triglyceride and lipid peroxide, improves high density lipoprotein, the metabolic effect of superabundant fats in the acceleration bodies; Selenium also has the strong anti-oxidation function, but prevention of cardiac; Anticancer by enhance immunity recognition system removing cancerous cell; Remove and the drainage heavy metal ion, hydrargyrum, methyl mercury, cadmium, lead etc. are had Detoxication; Scarce selenium can make the human insulin secretion reduce, impaired glucose tolerance, and oxidation resistance descends and quickens human senility and intelligence decline.

Chromium is insulin " collaborative hormone ", to have the effect of active organochromium compounds " glucose tolerance factor (GTF) " form enhancing insulin, mainly be to keep normal carbohydrate metabolism of body and lipid metabolism, following symptom can occur when not enough: weaken glucose tolerance, increase the weight of hyperglycemia, glucose in urine, hypoglycemia, the circulation of acceleration insulin, reduce Insulin receptor INSR quantity, reduce the insulin binding ability, lose weight, increase fat content, increase vision pressure etc.The chromium of two kinds of valence states of stable existence in the environment, i.e. trivalent chromium and Cr VI, trivalent chromium has physiologically active, uses useful and harmlessly in an amount of scope, and Cr VI is a kind of strong oxidizer, and human body is had toxic and side effects.

Copper is the active component of 30 plurality of enzymes such as lysyl oxidase in the body, cytochrome oxidase, monoamine oxidase, MAO, participates in the redox reaction of cell.When lacking copper, 7 α-hydroxyl enzyme and 12 α-hydroxylase activity that the catalysis cholesterol changes cholic acid into reduce, and cholesterol is synthetic and eliminate minimizing, and cholesterol is discharged and is obstructed, and causes hyperlipemia.Absolute or relative copper lacks can make serum TC, TG level raise, and causes high-cholesterol disease.

Molybdenum is one of micro elements needed by human, and it is the formation element of plurality of enzymes, can help the metabolism of carbohydrate and fat, it participates in removing the murder by poisoning of poisonous aldehydes in the human body, eliminate human free radical, have anticancer, defying age, enhancing immunity and anticariogenic function; Scarce molybdenum can bring out cardiovascular disease, cancer and dental caries.

Iodine is the main synthetic thyroid element that participates in human body, and thyroxinic physiological function is to regulate the organism metabolism level, influences the generation of body heat energy, blood glucose and ketoboidies level, muscle and nervous, many-sided functions such as body weight, intelligence and sexual function; Adult's iodine deficiency can cause thyromegaly.

Manganese participates in the formation of some enzymes in human body, it is the metabolism of involved in sugar and lipid not only, and all works in protein, DNA and RNA are synthetic.

Application contains Radix Ophiopogonis, Rhizoma Polygonati, vitamin B ₁, vitamin B ₂, vitamin B ₆, nicotiamide, pantothenic acid, biotin, vitamin B ₁₂, folic acid, vitamin E and trace element zinc, selenium, chromium, copper, molybdenum, iodine, manganese has been known as the compositions of active component, but with Radix Ophiopogonis, Rhizoma Polygonati, vitamin B ₁, vitamin B ₂, nicotiamide, pantothenic acid, biotin, vitamin B ₆, vitamin B ₁₂, folic acid, vitamin E and trace element zinc, selenium, chromium, copper, molybdenum, iodine, the manganese compatibility pharmaceutical composition report as yet that is used for blood sugar lowering and blood fat and treatment diabetes.

Current medicine that is used for blood sugar lowering and blood fat or health product kind have multiple, but action target spot is few, the link shortcoming, need perfectly, and have the medicine of side effect more, and cost and price are all very high in addition.

Summary of the invention:

In order to overcome the shortcoming and defect of existing blood sugar lowering and blood fat and treatment diabetes medicament, the purpose of this invention is to provide a kind of compositions, said composition is by Radix Ophiopogonis and the collaborative vitamin B that increases of Rhizoma Polygonati ₁, vitamin B ₂, nicotiamide, pantothenic acid, biotin, vitamin B ₆, vitamin B ₁₂, folic acid, vitamin E and trace element zinc, selenium, chromium, copper, molybdenum, iodine, manganese blood sugar lowering and blood fat effect, simultaneously by trace element zinc, selenium, chromium, copper, molybdenum, iodine, manganese and vitamin B ₁, vitamin B ₂, nicotiamide, pantothenic acid, biotin, vitamin B ₆, vitamin B ₁₂, folic acid, vitamin E, replenish and strengthen the effect that Radix Ophiopogonis and Rhizoma Polygonati fall blood sugar lowering and blood fat and treat diabetes, even chronic administration is also without any side effect; Because the result of broad research, the inventor has found Radix Ophiopogonis, Rhizoma Polygonati, vitamin B ₁, vitamin B ₂, nicotiamide, pantothenic acid, biotin, vitamin B ₆, vitamin B ₁₂, folic acid, vitamin E and trace element zinc, selenium, chromium, copper, molybdenum, iodine, manganese novel combination, this novel combination has synergy for blood sugar lowering and blood fat and treatment diabetes; And single with Radix Ophiopogonis, Rhizoma Polygonati, compound vitamin B, vitamin E and trace element zinc, selenium, chromium, copper, molybdenum, iodine, manganese, its effect is all not as good as this compositions; There is not incompatibility in this compositions, have no side effect, and cost is low, thereby constitutes the present invention.

The invention provides the pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes, it comprises Radix Ophiopogonis, Rhizoma Polygonati, vitamin B as active component ₁, vitamin B ₂, nicotiamide, pantothenic acid, biotin, vitamin B ₆, vitamin B ₁₂, folic acid, vitamin E and trace element zinc, selenium, chromium, copper, molybdenum, iodine, manganese.

Be the tuber of liliaceous plant Ophiopogon Radix Ophiopogonis japonicus (L.f.) Ker-Gawl. Radix Ophiopogonis, and main product is in Zhejiang, Sichuan and other places, and excavate summer, this product feeble QI perfume (or spice), and it is little sweet puckery to distinguish the flavor of, the toughness of chewing; The gentle person of, matter faint yellow, loose with the surface is good, gives birth to usefulness, and the present invention used Radix Ophiopogonis can be with its extract as raw material.

Rhizoma Polygonati is Liliaceae herbaceos perennial Rhizoma Polygonati Polygonatum sibiricum Red, Yunnan Rhizoma Polygonati P.kingianum Coll.et Hemsl. or Polygonatum cyrtonema Hua P.cyrtonema Hua rhizome, mostly be wild, big with piece, fertile profit, yellow skin are white, the transparent person of section is good, ripe Rhizoma Polygonati is big with darkish complexion, piece, the big person of oiliness is good, and the used Rhizoma Polygonati of the present invention can be with its extract as raw material.

Be used for vitamin B of the present invention ₁(VitaminB ₁), vitamin B ₂(VitaminB ₂), nicotiamide (Nicotinamide), pantothenic acid (Pantothenic Acid), biotin (Vitamin H), vitamin B ₆(VitaminB ₆), vitamin B ₁₂(VitaminB ₁₂), folic acid (FolicAcid), all are water soluble vitamins, do not accumulate in vivo; Vitamin E (Vitamin E) is a fatsoluble vitamin, and is useful and harmless by the used dosage of the present invention; Zinc (Zn), selenium (Se), chromium (Cr), copper (Cu), molybdenum (Mo), iodine (I) are micro elements needed by human, and manganese (Mn) is human body possibility essential trace element; Trace element zinc among the present invention can be selected zinc citrate for use, zinc gluconate, zinc acetate, zinc carbonate, zinc oxide, zinc chloride, zinc lactate, zinc sulfate, single zinc methionine etc., trace element-selenium can be selected Selenomethionine for use, methoxybenzyl cyanic acid selenium, the two cyanic acid selenium of phenylene, sodium selenite, selenocarrageenan, selenocysteine, the selenizing methionine, sodium selenate etc., trace element chromium can be selected chromium trichloride for use, nicotinic acid chromium, chromium picolinate, trivalent chromiums such as chromium yeast, trace copper can be selected curpic carbonate for use, copper citrate, copper gluconate, copper sulfate etc., trace element molybdenum can be selected ammonium molybdate for use, sodium molybdate etc., trace iodine can be selected potassium iodate etc. for use, trace element manganese can be selected manganese sulfate for use, manganese chloride, manganese gluconate, manganese glycerophosphate, manganese citrates etc. all have professional production factory and supplier.

Compositions of the present invention mainly is applicable to hyperglycemia, hyperlipidemia and diabetic population, and by the present invention, the effective dose of Radix Ophiopogonis is in whole crude drug 5000-15000mg/ days, and the effective dose of Rhizoma Polygonati is in whole crude drug 5000-15000mg/ days, vitamin B ₁Effective dose be 0.5-20mg/ days, vitamin B ₂Effective dose be 0.5-20mg/ days, the effective dose of nicotiamide is 5-50mg/ days, the effective dose of pantothenic acid is 2-20mg/ days, the effective dose of biotin is 0.01-0.1mg/ days, vitamin B ₆Effective dose be 0.5-10mg/ days, vitamin B ₁₂Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, the effective dose of vitamin E (in the alpha-tocopherol equivalent) is 5-150mg α-TE/ days, the effective dose of trace element zinc is counted 5-20mg/ days with element zinc, selenic effective dose is counted 0.015-0.1mg/ days with elemental selenium, the effective dose of chromium is counted 0.015-0.15mg/ days with elemental chromium, the effective dose of copper is counted 0.5-1.5mg/ days with elemental copper, molybdenic effective dose is counted 0.02-0.06mg/ days with molybdenum, the effective dose of iodine is counted 0.05-0.2mg/ days with elemental iodine, and the effective dose of manganese is counted 1-3mg/ days with element manganese.

Compositions of the present invention can or directly be taken by following pharmaceutical dosage forms dispenser, for example, oral formulations is (as granule, powder, capsule, ball, sheet, dry syrup, liquid formulation), or food such as food (as cookies), mix and prepare with other known additives, this class additive is for example: carrier, disintegrating agent, slow releasing agent, excipient, filler, covering, binding agent, lubricant, antioxidant, apply agent, coloring agent, correctives, sweeting agent, sucrose succedaneum, nutrition enhancer, flavouring agent, surfactant, plasticizer, the PH regulator, freshener, suspending agent, defoamer, antiseptic, thickening agent, solubilisation aids etc. are prepared or they are added food as functional component or additive by usual way.

By the present invention, Radix Ophiopogonis, Rhizoma Polygonati, vitamin B ₁, vitamin B ₂, nicotiamide, pantothenic acid, biotin, vitamin B ₆, vitamin B ₁₂, folic acid, vitamin E and trace element zinc, selenium, chromium, copper, molybdenum, iodine, manganese each component can distinguish preparation, the preparation of each component can be mixed the back when using and use or do not mix simultaneously and use.

Advantage of the present invention is the effect of this compositions from too many levels, multisystem, the collaborative performance of many target spots effect, blood sugar lowering and blood fat there are significant effect with the treatment diabetes, sufficient raw, cost is low, each component has no side effect in the compositions, no incompatibility.

Subordinate list 1 causes diabetic mice blood sugar lowering test effect relatively for adding this compositions and Radix Ophiopogonis Rhizoma Polygonati component and vitamin added elements component to alloxan.

Subordinate list 2 causes diabetes model rat blood fat reducing test effect relatively for adding this compositions and Radix Ophiopogonis Rhizoma Polygonati component and vitamin added elements component to (STZ).

Relatively tabulate below with reference to embodiment and test implementation example effect and to be described in detail the present invention.

Embodiment 1:

Radix Ophiopogonis 7500mg,

Rhizoma Polygonati 7500mg,

Vitamin B ₁3mg,

Vitamin B ₂3mg,

Vitamin B ₆2mg,

Zinc lactate (in trace element zinc) 10mg,

Sodium selenate (in trace element-selenium) 0.02mg,

Nicotinic acid chromium (in trace element chromium) 0.01mg,

Potassium iodate (in trace iodine) 0.1mg,

Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.

Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.

Embodiment 2:

Radix Ophiopogonis 8000mg,

Rhizoma Polygonati 8000mg,

Vitamin B ₁3mg,

Vitamin B ₂3mg,

Vitamin B ₆2mg,

Nicotiamide 10mg,

Zinc lactate (in trace element zinc) 8mg,

Sodium selenate (in trace element-selenium) 0.02mg,

Chromium yeast (in trace element chromium) 0.02mg,

Potassium iodate (in trace iodine) 0.1mg,

Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.

Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.

Embodiment 3:

Radix Ophiopogonis 8500mg,

Rhizoma Polygonati 8500mg,

Vitamin B ₁3mg,

Vitamin B ₂3mg,

Vitamin B ₆2mg,

Nicotiamide 10mg,

Zinc lactate (in trace element zinc) 8mg,

Sodium selenate (in trace element-selenium) 0.02mg,

Chromium yeast (in trace element chromium) 0.02mg,

Potassium iodate (in trace iodine) 0.1mg,

Sodium molybdate (in trace element molybdenum) 0.03mg,

Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.

Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.

Embodiment 4:

Radix Ophiopogonis 8800mg,

Rhizoma Polygonati 8800mg,

Vitamin B ₁3mg,

Vitamin B ₂3mg,

Vitamin B ₆2mg,

Nicotiamide 10mg,

Zinc lactate (in trace element zinc) 10mg,

Sodium selenate (in trace element-selenium) 0.02mg,

Chromium yeast (in trace element chromium) 0.02mg,

Copper citrate (in trace copper) 0.8mg,

Sodium molybdate (in trace element molybdenum) 0.03mg,

Potassium iodate (in trace iodine) 0.1mg,

Manganese citrate (in trace element manganese) 1mg,

Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.

Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.

Embodiment 5:

Radix Ophiopogonis 9500mg,

Rhizoma Polygonati 9500mg,

Vitamin B ₁3mg,

Vitamin B ₂3mg,

Vitamin B ₆2mg,

Nicotiamide 10mg,

Biotin 0.05mg,

Zinc lactate (in trace element zinc) 10mg,

Sodium selenate (in trace element-selenium) 0.02mg,

Chromium yeast (in trace element chromium) 0.02mg,

Copper citrate (in trace copper) 0.8mg,

Sodium molybdate (in trace element molybdenum) 0.03mg,

Potassium iodate (in trace iodine) 0.1mg

Manganese citrate (in trace element manganese) 1mg,

Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.

Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn.

Embodiment 6:

Radix Ophiopogonis 9800mg,

Rhizoma Polygonati 9800mg,

Vitamin B ₁3mg,

Vitamin B ₂3mg,

Vitamin B ₆2mg,

Nicotiamide 10mg,

Pantothenic acid 8mg

Biotin 0.05mg,

Zinc lactate (in trace element zinc) 10mg,

Sodium selenate (in trace element-selenium) 0.02mg,

Chromium yeast (in trace element chromium) 0.02mg,

Copper citrate (in trace copper) 0.8mg,

Sodium molybdate (in trace element molybdenum) 0.03mg,

Potassium iodate (in trace iodine) 0.1mg

Manganese citrate (in trace element manganese) 1mg,

Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.

Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn.

Embodiment 7:

Radix Ophiopogonis 5000mg,

Rhizoma Polygonati 5000mg,

Vitamin B ₁0.5mg,

Vitamin B ₂0.5mg,

Vitamin B ₆0.5mg,

Vitamin B ₁₂0.001mg,

Folic acid 0.1mg,

Nicotiamide 5mg,

Pantothenic acid 2mg,

Biotin 0.01mg,

Zinc lactate (in trace element zinc) 5mg,

Sodium selenate (in trace element-selenium) 0.015mg,

Chromium yeast (in trace element chromium) 0.015mg,

Copper citrate (in trace copper) 0.5mg,

Sodium aluminate (in trace element molybdenum) 0.02mg,

Potassium iodate (in trace iodine) 0.05mg,

Manganese citrate (in trace element manganese) 1mg,

Vitamin E (in the alpha-tocopherol equivalent) 5mg α-TE.

Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn.

Embodiment 8:

Radix Ophiopogonis 15000mg,

Rhizoma Polygonati 15000mg,

Vitamin B ₁20mg,

Vitamin B ₂20mg,

Vitamin B ₆10mg,

Vitamin B ₁₂0.025mg,

Folic acid 1mg,

Nicotiamide 50mg,

Pantothenic acid 20mg,

Biotin 0.1mg,

Zinc lactate (in trace element zinc) 20mg,

Sodium selenate (in trace element-selenium) 0.1mg,

Chromium yeast (in trace element chromium) 0.15mg,

Copper citrate (in trace copper) 1.5mg,

Sodium molybdate (in trace element molybdenum) 0.06mg,

Potassium iodate (in trace iodine) 0.2mg,

Manganese citrate (in trace element manganese) 3mg,

Vitamin E (in the alpha-tocopherol equivalent) 150mg α-TE.

Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn, serve on 10, withdrew 5, obeyed again 10.

Confirm that through animal experiment this compositions belongs to nontoxic level; The crowd takes and does not also see toxicity.

Embodiment 9:

Select 60 of Kunming mouses, male female half and half; Wherein 48 mices are male female half and half, and fasting is after 16 hours, tail vein injection alloxan 70mg/kg ^-1After 72 hours, measure fasting blood sugar, blood glucose value is higher than 16.7mmol.L ^-1The person is the hyperglycemia mice, according to blood sugar level the hyperglycemia mice is divided into 4 groups: model control group (B group), and the C group, the D group, the E group, each group of test is pressed 0.2mL.10g ^-1Continuous 10 days of body weight gastric infusion, fasting in the 10th day gastric infusion after 7 hours is measured after the administration 1 hour with method, 2 hours blood glucose value; 12 remaining mices, as normal control group (A group), model control group and normal control group irritate stomach once for the equal-volume normal saline every day.

Related data sees attached list 1.

Subordinate list 1: add this compositions and Radix Ophiopogonis Rhizoma Polygonati component and vitamin added elements component alloxan is caused diabetic mice blood sugar lowering test effect relatively:

Embodiment 10:

Selecting SD is 48 feeds of male rat high lipid food, press an intraperitoneal injection STZ of 25mg/kg body weight (streptozotocin) after raising for 4 weeks, fasting is after 8 hours after 2 weeks, gavage the 20%D-glucose solution by the 2g/kg body weight, do the oral glucose tolerance test, all 0 and 2 hour blood glucose is respectively greater than 7.0 and the rat of 11.0mmol/L, as diabetes modeling success rat, modeling success rat is divided into 4 groups at random, every group 12, be respectively the A group, the B group, the C group, D group, test are respectively organized distilled water suspension oral gavage that every day, per os gave checking matter and equivalent once, and matched group gives the equivalent normal saline and irritate stomach once every day, in administration 12 week back fasting on the 3rd 10 hours, the carotid artery blood sampling is measured T-CHOL respectively, triglyceride, high density lipoprotein, three indexs.

Related data sees attached list 2.

Subordinate list 2: add this compositions and Radix Ophiopogonis Rhizoma Polygonati component and vitamin added elements component (STZ) caused diabetes model rat blood fat reducing test effect relatively:

From table 1, can obviously find out, take this composite preparation and add the difference that Rhizoma Polygonati component and vitamin added elements component contrast diabetic mice blood sugar lowering test effect has highly significant Radix Ophiopogonis with taking.

From table 2, can obviously find out, take this composite preparation and add the difference that Rhizoma Polygonati component and vitamin added elements component contrast high blood lipid model rat blood fat reducing test effect has highly significant Radix Ophiopogonis with taking.

Claims (7)

1, a kind of pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes is characterized in that it is made by weight ratio by following raw materials according:

Radix Ophiopogonis 5000-15000mg,

Rhizoma Polygonati 5000-15000mg,

Vitamin B ₁0.5-20mg,

Vitamin B ₂0.5-20mg,

Vitamin B ₆0.5-10mg,

Vitamin B ₁₂0-0.025mg,

Folic acid 0-1mg,

Nicotiamide 0-50mg,

Pantothenic acid 0-20mg,

Biotin 0-0.1mg,

Zinc 5-20mg,

Selenium 0.015-0.1mg,

Chromium 0.015-0.15mg,

Copper 0-1.5mg,

Molybdenum 0-0.06mg,

Iodine 0.05-0.2mg,

Manganese 0-3mg,

Vitamin E 5-150mg a-TE.

2, the pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:

Radix Ophiopogonis 5000-15000mg,

Rhizoma Polygonati 5000-15000mg,

Vitamin B ₁0.5-20mg,

Vitamin B ₂0.5-20mg,

Vitamin B ₆0.5-10mg,

Vitamin B ₁₂0-0.025mg,

Folic acid 0-1mg,

Nicotiamide 5-50mg,

Pantothenic acid 0-20mg,

Biotin 0-0.1mg,

Zinc 5-20mg,

Selenium 0.015-0.1mg,

Chromium 0.015-0.15mg,

Copper 0-1.5mg,

Molybdenum 0-0.06mg,

Iodine 0.05-0.2mg,

Manganese 0-3mg,

Vitamin E 5-150mg a-TE.

3, the pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:

Radix Ophiopogonis 5000-15000mg,

Rhizoma Polygonati 5000-15000mg,

Vitamin B ₁0.5-20mg,

Vitamin B ₂0.5-20mg,

Vitamin B ₆0.5-10mg,

Vitamin B ₁₂0-0.025mg,

Folic acid 0-1mg,

Nicotiamide 5-50mg,

Pantothenic acid 0-20mg,

Biotin 0-0.1mg,

Zinc 5-20mg,

Selenium 0.015-0.1mg,

Chromium 0.015-0.15mg,

Copper 0-1.5mg,

Molybdenum 0.02-0.06mg,

Iodine 0.05-0.2mg,

Manganese 0-3mg,

Vitamin E 5-150mg a-TE.

4, the pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:

Radix Ophiopogonis 5000-15000mg,

Rhizoma Polygonati 5000-15000mg,

Vitamin B ₁0.5-20mg,

Vitamin B ₂0.5-20mg,

Vitamin B ₆0.5-10mg,

Vitamin B ₁₂0-0.025mg,

Folic acid 0-1mg,

Nicotiamide 5-50mg,

Pantothenic acid 0-20mg,

Biotin 0-0.1mg,

Zinc 5-20mg,

Selenium 0.015-0.1mg,

Chromium 0.015-0.15mg,

Copper 0.5-1.5mg,

Molybdenum 0.02-0.06mg,

Iodine 0.05-0.2mg,

Manganese 1-3mg,

Vitamin E 5-150mg a-TE.

5, the pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:

Radix Ophiopogonis 5000-15000mg,

Rhizoma Polygonati 5000-15000mg,

Vitamin B ₁0.5-20mg,

Vitamin B ₂0.5-20mg,

Vitamin B ₆0.5-10mg,

Vitamin B ₁₂0-0.025mg,

Folic acid 0-1mg,

Nicotiamide 5-50mg,

Pantothenic acid 0-20mg,

Biotin 0.01-0.1mg,

Zinc 5-20mg,

Selenium 0.015-0.1mg,

Chromium 0.015-0.15mg,

Copper 0.5-1.5mg,

Molybdenum 0.02-0.06mg,

Iodine 0.05-0.2mg,

Manganese 1-3mg,

Vitamin E 5-150mg a-TE.

6, the pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:

Radix Ophiopogonis 5000-15000mg,

Rhizoma Polygonati 5000-15000mg,

Vitamin B ₁0.5-20mg,

Vitamin B ₂0.5-10mg,

Vitamin B ₆0.5-20mg,

Vitamin B ₁₂0-0.025mg,

Folic acid 0-1mg,

Nicotiamide 5-50mg,

Pantothenic acid 2-20mg,

Biotin 0.01-0.1mg,

Zinc 5-20mg,

Selenium 0.015-0.1mg,

Chromium 0.015-0.15mg,

Copper 0.5-1.5mg,

Molybdenum 0.02-0.06mg,

Iodine 0.05-0.2mg,

Manganese 1-3mg,

Vitamin E 5-150mg a-TE.

7, the pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:

Radix Ophiopogonis 5000-15000mg,

Rhizoma Polygonati 5000-15000mg,

Vitamin B ₁0.5-20mg,

Vitamin B ₂0.5-10mg,

Vitamin B ₆0.5-20mg,

Vitamin B ₁₂0.001-0.025mg,

Folic acid 0.1-1mg,

Nicotiamide 5-50mg,

Pantothenic acid 2-20mg,

Biotin 0.01-0.1mg,

Zinc 5-20mg,

Selenium 0.015-0.1mg,

Chromium 0.015-0.15mg,

Copper 0.5-1.5mg,

Molybdenum 0.02-0.06mg,

Iodine 0.05-0.2mg,

Manganese 1-3mg,

Vitamin E 5-150mg a-TE.