CN101587117A - Continuous detecting device and continuous detecting system - Google Patents
Continuous detecting device and continuous detecting system Download PDFInfo
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- CN101587117A CN101587117A CNA200810098024XA CN200810098024A CN101587117A CN 101587117 A CN101587117 A CN 101587117A CN A200810098024X A CNA200810098024X A CN A200810098024XA CN 200810098024 A CN200810098024 A CN 200810098024A CN 101587117 A CN101587117 A CN 101587117A
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Abstract
The invention relates to a continuous detecting device used for detecting the concentration of a target object in fluid. The continuous detecting device comprises a first chip, a signal source and a second chip. The first chip comprises a separating unit and a reacting unit. The separating unit can be used for separating the target object and a non-target object in the fluid. The reacting unit is used for making the fluid without the non-target object react with a reagent. The signal source is used for providing a signal to pass through the fluid which is reacted with the reagent. The second chip is arranged on one side of the first chip, and comprises a signal conversion element and a processing unit. The signal conversion element is used for receiving the signal passing through the fluid, and outputs an electrical signal according to the signal. The processing unit is used for getting the concentration of the target object according to the electrical signal. The concentration information of the target object can be continuously obtained, and a corresponding processing procedure is carried out according to the concentration of the target object in real time.
Description
Technical field
The present invention relates to a kind of pick-up unit and detection system, and particularly relate to a kind of pick-up unit and detection system of continous way.
Background technology
General common medical detecting method is undertaken by the mode of blood drawing, for example utilizes blood drawing to carry out the detection of the concentration of patient's blood sugar concentration, blood cell quantity or troponin (troponin).When for example detecting blood sugar concentration, be after blood drawing, to utilize the domestic type blood sugar test instrument of photovoltaic principals or electrochemical principle to detect; Perhaps in medical centre, utilize hydro-extractor or large-scale biochemical analyzer, blood cell, serum after separating are detected.
Yet the coherent detection equipment of present blood sugar and serum, the operation that all needs elder generation independently to draw blood then moves to a corpse or other object for laboratory examination and chemical testing in the checkout equipment again and analyzes.The testing staff carries out corresponding disposal means according to testing result, for example applies operations such as beating insulin.The mode of this manual detection is not only consuming time, and can't dispose at patient's situation immediately.In addition, in the process that a corpse or other object for laboratory examination and chemical testing moves, a corpse or other object for laboratory examination and chemical testing is subjected to the pollution of external substance easily; Moreover, if when a corpse or other object for laboratory examination and chemical testing has highly biochemical contaminative, increased the chance that the testing staff is infected greatly.In addition, general common on the market checkout equipment, application examples such as hydro-extractor separate or blood cell isolation technics such as capillary separation, and it has blood cell and breaks easily and cause haemolysis, and blood cell separates shortcomings such as incomplete, influences testing result so to a great extent.Moreover because many illnesss all need long-time timing to detect, the detection method of conventional manual need repeat to use pin to the patient, has increased the inconvenience of detection and the chance that the patient is infected, and causes the waste of medical equipment simultaneously.
Summary of the invention
The invention provides a kind of continuous detecting device and continuous detecting system, it utilizes separative element and reaction member integrated (integration) mode on same chip, makes that fluid can be in regular turn by separative element and reaction member in the continuous detecting flow process.Object and non-object can directly separate on chip, and can directly carry out the reaction of liquid and reagent on chip, thereby detect and obtain the concentration of object in real time.So can carry out the monitoring of object concentration continuously for a long time, carry out corresponding operation with the variation according to object concentration at any time.
According to an aspect of the present invention, a kind of continuous detecting device is proposed, in order to the concentration of the object in the test fluid.Continuous detecting device comprises first chip, signal source and second chip.First chip comprises separative element and reaction member.Separative element is in order to the non-object in separate targets thing and the fluid.Reaction member is with so that isolate the fluid and the reagent of non-object and react.Signal source in order to provide signal by with the fluid of reagent reacting.Second chip is arranged on a side of first chip, and comprises signal conversion element (signaltransducing element) and processing unit.Signal conversion element is in order to receiving the signal by fluid, and according to signal output electric signal.Processing unit is in order to obtain the concentration of object according to electric signal.
According to continuous detecting device of the present invention, wherein, this second chip more comprises: signal generator, and in order to waveform signal is provided to this at least one reaction channel, to produce the wet effect of this electricity.
According to continuous detecting device of the present invention, more comprise: housing, this first chip, this signal source and this second chip are arranged in this housing; Wherein, this first chip is arranged in this housing in the mode that can substitute.
According to continuous detecting device of the present invention, wherein, this signal source is a light-emitting component, and this signal is a light signal.
According to continuous detecting device of the present invention, wherein, this signal conversion element is a photoelectric commutator.
According to continuous detecting device of the present invention, more comprise: battery is coupled to this signal source and this second chip, electric energy is provided to this signal source and this second chip.
According to continuous detecting device of the present invention, wherein, this first chip has sprue, and this sprue connects this separative element and this reaction member, in order to transfer this fluid.
According to continuous detecting device of the present invention, wherein, this signal conversion element and this processing unit are formed on this second chip via integrated (integration) semiconductor technology.
According to a further aspect in the invention, a kind of continuous detecting system is proposed, in order to the concentration of the object in the test fluid.Continuous detecting system comprises continuous detecting device and dispensing unit.Continuous detecting device comprises first chip, signal source and second chip.First chip comprises separative element and reaction member.Separative element is in order to the non-object in separate targets thing and the fluid.Reaction member is with so that isolate the fluid and the reagent of non-object and react.Signal source in order to provide signal by with the fluid of reagent reacting.Second chip is arranged on a side of first chip, and comprises signal conversion element and processing unit.Signal conversion element is in order to receiving the signal by fluid, and according to signal output electric signal.Processing unit is in order to obtain the concentration of object according to electric signal.The dispensing unit is coupled to processing unit, in order to concentration adjustment dispensing concentration or the dispensing frequency according to object.
According to continuous detecting system of the present invention, wherein, this continuous detecting system is connected to external power source, and this external power source is in order to be provided to this signal source and this second chip to major general's electric energy.
For above-mentioned purpose of the present invention, feature and advantage can be become apparent, preferred embodiment cited below particularly, and in conjunction with the accompanying drawings, be described in detail below:
Description of drawings
Fig. 1 illustrates the synoptic diagram according to the continuous detecting system of first embodiment of the invention;
Fig. 2 illustrates among Fig. 1 the sectional view along A-A ' line; And
Fig. 3 illustrates the synoptic diagram according to the continuous detecting system of second embodiment of the invention.
Embodiment
Continuous detecting system according to the preferred embodiment of the invention, to and signal conversion element and processing unit be integrated on second chip in order to the separative element of object in the separation of the fluid and non-object and with so that the reaction member that fluid and reagent react is integrated on first chip.After fluid is isolated non-object via separative element, can directly on first chip, react, and, further obtain the concentration of object by the signal of signal conversion element reception by fluid with reagent.So obtain the concentration information of object serially, and carry out corresponding handling procedure in real time according to the concentration of object.Below propose first and second embodiment and be elaborated, these two embodiment are only in order to as the example explanation, can't limit the present invention and want the scope protected.In addition, the accompanying drawing among the embodiment omits unnecessary element, with clear demonstration technical characterstic of the present invention.
First embodiment
Please refer to Fig. 1, it illustrates the synoptic diagram according to the continuous detecting system of first embodiment of the invention.Continuous detecting system 200 mainly comprises continuous detecting device 100, and it is in order to the concentration of the object T1 in the test fluid.Continuous detecting device 100 comprises first chip 110, signal source 130 and second chip 120.First chip 110 comprises separative element 113 and reaction member 115.Separative element 113 is in order to the non-object T2 in separate targets thing T1 and the fluid.Reaction member 115 usefulness are so that isolate fluid and the reagent of non-object T2 and react.Signal source 130 in order to provide signal S by with the fluid of reagent reacting.Second chip 120 is arranged on a side of first chip 110, comprises signal conversion element 123 and processing unit 125.Signal conversion element 123 is in order to receiving the signal S by fluid, and according to the signal output electric signal that receives.Processing unit 125 is in order to receiving electric signal, and obtains the concentration of object T1 in fluid according to electric signal.In addition, continuous detecting system 200 more comprises the dispensing unit 180 that is coupled to processing unit 125, in order to concentration adjustment dispensing concentration or the dispensing frequency according to object T1.Continuous detecting system 200 utilizes separative element 113 to isolate non-object T2 from fluid, can improve the accuracy that detects object T1 concentration.Then, fluid and reagent directly react in reaction member 115, and carry out the detection of object T1 concentration in real time, can shorten detection time, make dispensing unit 180 to carry out corresponding adjustment operation according to the concentration of object T1 immediately.
Further, first chip 110 has sprue (main fluidic channel) 110a, and it connects separative element 113 and reaction member 115, in order to transfer fluid.Sprue 110a forms fluid intake 110c at a side of first chip 110, contains the fluid of object T1 and non-object T2, is transferred by fluid intake 110c to enter in the continuous detecting device 100.Separative element 113 for example comprises electrode group 113a, and it is arranged on the both sides of sprue 110a, in order in fluid, produce dielectrophoretic force (dielectrophoretic force, DEPforce), with object T1 in the separation of the fluid and non-object T2.In addition, the separative element 113 of present embodiment more can comprise light tweezer folder (optical tweezers) 113b except that comprising former electrodes group 113a, and in order to provide focused ray L to fluid, focused ray L can be laser beam.When focused ray L directive fluid, utilize the transfer of the photon momentum of focused ray L, object T1 and the non-object T2 of acting force in the fluid is provided.Light tweezer folder 113b is by wavelength, intensity distributions, focusing angle and the object T1 of focused ray L and the characteristics such as shape, refractive index and absorptivity of non-object T2, change the moving direction of object T1 and non-object T2, thus separate targets thing T1 and non-object T2.About the principle of work of light tweezer folder 113b, known by those of ordinary skill in the correlative technology field, no longer given unnecessary details herein.As shown in Figure 1, in the continuous detecting system 200 according to the embodiment of the invention, separative element 113 comprises electrode group 113a and light tweezer folder 113b simultaneously, thus object T1 and non-object T2 effectively in the separation of the fluid.Yet, in different embodiments, can select a ground in the separative element 113 electrode group 113a is arranged on sprue 110a both sides, perhaps should be with light tweezer folder 113b, as the separation mechanism of object T1 and non-object T2.On the other hand, isolated non-object T2 can transfer and leave first chip 110, to store according to demand or to discard.
On the one hand, the reaction member 115 of present embodiment comprises at least one reaction chamber 115a and many fluid channel (micro-fluidic channel) 115b in addition, and reaction member 115 describes to comprise a plurality of reaction chamber 115a herein.These fluid channel 115b is communicated with sprue 110a and these reaction chambers 115a, enters these reaction chambers 115a by the fluid behind the separative element 113 via these fluid channel 115b.These reaction chambers 115a reacts fluid and reagent in order to ccontaining fluid and reagent.Then carry out the detection of object T1 concentration with the fluid behind the reagent reacting.In the present embodiment, reagent can for example be to transfer via reagent transmission unit (not shown in the accompanying drawing) to enter among these reaction chambers 115a.First chip 110 can be semi-conductor chip, and these reaction chambers 115a and these fluid channel 115b can (photoetching, photolithography) technology be formed on first chip 110 by photoetch.In addition, first chip 110 can comprise waste liquid storage tank 110b in addition, is communicated with these fluid channel 115b, and is arranged on the rear of reaction member 115, in order to fluid and the reagent after ccontaining reaction back, the detection.This waste liquid storage tank 110b can form in the step of the photoetch that forms these reaction chambers 115a and these fluid channel 115b simultaneously.Please refer to Fig. 2, it illustrates among Fig. 1 the sectional view along A-A ' line.Reaction chamber 115a advantageously has enough spaces so that fluid and reagent delay a period of time in reaction chamber 115a makes fluid and reagent fully to react.In addition, the size of these reaction chambers 115a, and the connected mode of reaction chamber 115a and fluid channel 115b can design according to different demands, and present embodiment is not limited.In addition, the fluid that enters reaction chamber 115a has been isolated non-object T2, can avoid the detection of non-object T2 jamming target thing T1 concentration, improves the accuracy that detects.
In addition, signal source 130 can be light-emitting component in the present embodiment, and light emitting diode for example for example is a light signal by the signal S with the fluid of reagent reacting, and signal conversion element 123 for example is photoelectric commutator (photo-electro transducer).In the practical application, first chip 110 is a light-transmitting materials corresponding to the place of reaction chamber 115a, when light-emitting component orientating reaction chamber 115a emission light signal, this light signal penetrates by the fluid among the reaction chamber 115a and first chip 110, and is projeced into photoelectric commutator.Photoelectric commutator detects and carries out the intensity or the color of the reacted light of light absorption via fluid, and exports electric signal thus to processing unit 125.Processing unit 125 carries out the concentration that computing obtains object T1 in the fluid according to electric signal.In the present embodiment, second chip 120 can for example be a semi-conductor chip, signal conversion element 123 and processing unit 125 can be formed on second chip 120 via integrated semiconductor technology, simplify the processing step of continuous detecting device 100 relatively, to improve process efficiency and to reduce cost.
Moreover continuous detecting system 200 can comprise display unit 190 in addition, is coupled to processing unit 125, shows the testing result picture in order to the concentration according to object T1, allows the user can learn the situation of detection easily, improves the convenience that uses.
Below with the continuous detecting system 200 of first embodiment of the invention, be that example describes with the concentration of glucose that is applied to detect in the blood.Testee's blood is transferred first chip 110 that enters continuous detecting device 100 via corpse or other object for laboratory examination and chemical testing transmission unit (syringe of for example drawing blood), and corpse or other object for laboratory examination and chemical testing transmission unit is connected in testee and fluid intake 110c.Blood then is transferred to separative element 113 via sprue 110a, will separate in blood cell (the non-object T2) autoblood by separative element 113.The serum that contains glucose (object T1) then is transferred to reaction member 115.In reaction member 115, serum is transferred among the reaction chamber 115a by fluid channel 115b, and the glucose molecule in the serum reacts with reagent in reaction chamber 115a.Reaction chamber 115a advantageously has enough capacity, makes glucose and reagent be detained a period of time in reaction chamber 115a, fully to react.Then, for example be that the signal source 130 of light emitting diode provides light signal to pass reacted serum, further to pass through the concentration of the light absorption reaction detection glucose of serum.Signal conversion element 123 receives by the light behind the serum, and exports electric signal to processing unit 125 according to the intensity of light.Processing unit 125 is compared and computing according to electric signal, to obtain the concentration of glucose.The concentration of glucose that display unit 190 is obtained according to processing unit 125 shows the testing result picture, makes the testing staff learn whether concentration of glucose is normal.Further, the concentration of glucose that dispensing unit 180 is obtained according to processing unit 125, adjustment is injected to testee's the drug concentrations and the interval time of injectable drug, adjusts testee's blood sugar concentration with correspondence.On the other hand, the serum that detects after finishing then is transferred to waste liquid storage tank 110b, to be stored in the continuous detecting device 100, avoids serum to leave continuous detecting device 100, can reduce the danger that infects and pollute.In addition, when carrying out another testee's blood testing, only need first chip 110 is extracted out in housing 140, and another first chip is more changed in the housing 140 phenomenon that so can avoid aleopation and detect corpse or other object for laboratory examination and chemical testing mistake.
The above-mentioned mode of utilizing the continuous detecting system 200 detection blood sugar concentrations of first embodiment of the invention, can obtain a corpse or other object for laboratory examination and chemical testing from the testee at regular time and quantity and continuously, directly carry out the detection of blood sugar concentration in mode that need not processed offline, and can adjust dispensing concentration and dispensing frequency by dispensing unit 180 in real time.It has and need not repeat with pin, fast detecting blood sugar concentration, improves and detect degree of accuracy, exempt outside contamination and avoid advantage such as blood infection.Above-mentioned continuous detecting system 200 according to first embodiment of the invention is that example describes with the concentration of glucose that is applied to detect in the blood, yet the technology of the embodiment of the invention is not restricted to this.The continuous detecting system 200 of present embodiment also can be applicable to other chemical substance, a medical science corpse or other object for laboratory examination and chemical testing, a biological corpse or other object for laboratory examination and chemical testing or other has the detection of the fluid of continuously long-time detection demand.
Second embodiment
The continuous detecting system of present embodiment and above-mentioned continuous detecting system according to first embodiment of the invention, difference mainly is the design of first chip, all the other something in common are omitted and are no longer repeated to give unnecessary details.
Please refer to Fig. 3, it illustrates the synoptic diagram according to the continuous detecting system of second embodiment of the invention.Continuous detecting system 400 comprises continuous detecting device 300 and dispensing unit 380.Continuous detecting device 300 comprises first chip 310, signal source 330 and second chip 320.First chip 310 comprises separative element 313 and reaction member 315.Separative element 313 is in order to object T1 in the separation of the fluid and non-object T2, and comprises electrode group 313a or light tweezer folder 313b, or comprises electrode group 313a and light tweezer folder 313b simultaneously.In favourable embodiment, reaction member 315 comprises at least one reaction channel 310d, the two ends of reaction channel 310d receive fluid and reagent respectively, and enter in the reaction channel 310d to react by wet effect (electric moistening effect, electrowetting effect) control fluid of electricity and reagent.Signal source 330 in order to provide signal S ' by with the fluid of reagent reacting, signal S ' can be light signal, and its fluid and reagent by being arranged in reaction channel 310d.Second chip 320 comprises signal conversion element 323, processing unit 325 and signal generator (waveform generator, function generator) 327.Signal generator 327 makes reaction channel 310d can produce the wet effect of electricity in order to provide waveform signal to reaction channel 310d.In addition, signal generator 327 more can provide waveform signal to electrode group 313a, to change the size and the pattern (pattern) of dielectrophoretic force at different non-object T2.
Further, reaction channel 310d is formed in identical light etching process on first chip 310 with the sprue 310a and the waste liquid storage tank 310b of first chip 310.In addition, have more reagent on first chip 310 and transfer runner 310e, the end that reagent is transferred runner 310e connects reagent trough (not shown in the accompanying drawing), enters first chip 310 in order to transfer reagent; Reagent is transferred the other end coupled reaction passage 310d of runner 310e.Reaction channel 310d utilizes the wet effect of electricity to change its sidewall hydrophilic and hydrophobic matter, thereby fluid and reagent enter among the reaction channel 310d and reacts among the control sprue 310a.On the other hand, by the wet effect of electricity of reaction channel 310d, more can make fluid and reagent among the reaction channel 310d form focused droplet, in order to light signal is focused on, the accuracy of signal conversion element 323 received signal S ' can be improved, and the fluid that detects and the consumption of reagent can be saved.
In addition, the continuous detecting system 400 of present embodiment is connected to external power source E, presss from both sides 313b, signal source 330 and second chip 320 in order to stable electric energy to electrode group 313a, light tweezer to be provided.Moreover continuous detecting device 300 can comprise that housing 340, the first chips 310, signal source 330 and second chip 320 are arranged in the housing 340 in addition.In addition, continuous detecting system 400 can comprise display unit 390 in addition, in order to show the testing result picture.
Above-mentioned according to the present invention the continuous detecting system of first and second embodiment, separative element and reaction member are integrated on the one chip, can reduce the volume of pick-up unit, and utilize the detection mode of continous way, the sustainable concentration information that obtains object, thereby carry out corresponding handling procedure in real time, reach the effect of real-time monitoring.In addition,, can avoid fluid to expose and cause infection, or external substance enters and causes pollution problems by the testing process of non-off-line.In addition, signal conversion element, processing unit and signal generator can form by integrated semiconductor technology, can save processing step and cost.Moreover, by directly substituting the mode of first chip, can avoid the problem of aleopation between different fluid or different testee.In addition, cause runner to be blocked, make when detection can't be carried out smoothly, also can get rid of rapidly via the mode of substituting first chip owing to particulate in the fluid is attached to tube wall.Secondly, utilize at reaction channel to form the wet effect of electricity and produce focused droplet, can improve the detection degree of accuracy, and reduce the requirement of fluid, and save the consumption of reagent.
In sum, though the present invention with the preferred embodiment disclosure as above, yet it is not in order to limit the present invention.The ordinary technical staff in the technical field of the invention without departing from the spirit and scope of the present invention, should make various changes and modification.Therefore, protection scope of the present invention should be as the criterion with the scope of appended subsequently claim.
The main element symbol description
100,300: continuous detecting device 110,310: the first chips
110a, 310a: sprue 110b, 310b: waste liquid storage tank
110c: fluid flow port 113,313: separative element
113a, 313a: electrode group 113b, 313b: light tweezer folder
115,315: reaction member 115a: reaction chamber
115b: fluid channel 120,320: the second chips
123,323: signal conversion element 125,325: processing unit
129: battery 130,330: signal source
140,340: housing 180,380: the dispensing unit
190,390: display unit 200,400: continuous detecting system
310d: reaction channel 310e: reagent is transferred runner
327: signal generator E: external power source
L: focused ray S, S ': signal
T1: object T2: non-object.
Claims (10)
1. continuous detecting device, in order to the concentration of the object in the test fluid, described continuous detecting device comprises:
First chip comprises:
Separative element is in order to separate the non-object in described object and the described fluid; And
Reaction member is with so that isolate the described fluid and the reagent of described non-object and react;
Signal source, in order to provide signal by with the described fluid of described reagent reacting; And
Second chip is arranged on a side of described first chip, and comprises:
Signal conversion element, in order to the described signal of reception by described fluid, and according to described signal output electric signal; And
Processing unit is in order to obtain the concentration of described object according to described electric signal.
2. continuous detecting device according to claim 1, wherein, described separative element comprises:
The electrode group, in order to producing dielectrophoretic force in described fluid, separating described object and the described non-object in the described fluid, and described electrode group is attached on described first chip in order to prevent described object and described non-object.
3. continuous detecting device according to claim 1, wherein, described separative element comprises:
Light tweezer folder is in order to be provided to focused ray described fluid, to separate described object and the described non-object in the described fluid.
4. continuous detecting device according to claim 1, wherein, described reaction member comprises:
At least one reaction chamber is in order to ccontaining described fluid and described reagent; And
Many fluid channel are communicated with described at least one reaction chamber.
5. continuous detecting device according to claim 4, wherein, described at least one reaction chamber and described fluid channel are formed on described first chip by light etching process.
6. continuous detecting device according to claim 4, wherein, described first chip more comprises:
The waste liquid storage tank is communicated with described fluid channel and is arranged on described reaction member rear, in order to ccontaining reacted described fluid and described reagent.
7. continuous detecting device according to claim 1, wherein, described reaction member comprises:
At least one reaction channel, the two ends of described at least one reaction channel receive described fluid and described reagent respectively, and described at least one reaction channel controls described fluid by the wet effect of electricity and described reagent enters in described at least one reaction channel to react.
8. continuous detecting device according to claim 7, wherein, described at least one reaction channel is formed on described first chip by light etching process.
9. continuous detecting device according to claim 7, wherein, described fluid in described at least one reaction channel and described reagent also form focused droplet by the wet effect of described electricity.
10. continuous detecting system, in order to the concentration of the object in the test fluid, described continuous detecting system comprises:
Continuous detecting device comprises:
First chip comprises:
Separative element is in order to separate the non-object in described object and the described fluid; And
Reaction member is with so that isolate the described fluid and the reagent of described non-object and react;
Signal source, in order to provide signal by with the described fluid of described reagent reacting; And
Second chip is arranged on a side of described first chip, and comprises:
Signal conversion element, in order to the described signal of reception by described fluid, and according to described signal output electric signal; And
Processing unit is in order to obtain the concentration of described object according to described electric signal; And
The dispensing unit is coupled to described processing unit, in order to concentration adjustment dispensing concentration or the dispensing frequency according to described object.
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| CN 200810098024 CN101587117B (en) | 2008-05-20 | 2008-05-20 | Continuous detecting device and continuous detecting system |
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| CN 200810098024 CN101587117B (en) | 2008-05-20 | 2008-05-20 | Continuous detecting device and continuous detecting system |
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| CN101587117A true CN101587117A (en) | 2009-11-25 |
| CN101587117B CN101587117B (en) | 2013-08-14 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000235028A (en) * | 1999-02-16 | 2000-08-29 | Terumo Corp | Blood component measuring device and blood component measuring method |
| CN1419651A (en) * | 2000-03-22 | 2003-05-21 | 全麦迪科斯有限责任公司 | Electrochemical biosensor test strip with recognition electrode and readout meter using this test strip |
| CN1456680A (en) * | 2002-05-10 | 2003-11-19 | 生命扫描有限公司 | Multi-layer reagent strips and method for measuring saccharfied protein in physiological samples |
| TWI281947B (en) * | 2003-07-30 | 2007-06-01 | Bing-Huei Chen | A capillary biochip and detecting device of the same |
| JP3949126B2 (en) * | 1997-03-19 | 2007-07-25 | テルモ株式会社 | Component measurement chip |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10315396A1 (en) * | 2003-04-04 | 2004-10-14 | Lieblein, Martin, Dr. | Automatic blood sugar monitor and warning system, for hypo- and hyperglycemia, has a finger stall containing the electromagnetic pricker and test strips with a glucose enzyme linked to a control |
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2008
- 2008-05-20 CN CN 200810098024 patent/CN101587117B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3949126B2 (en) * | 1997-03-19 | 2007-07-25 | テルモ株式会社 | Component measurement chip |
| JP2000235028A (en) * | 1999-02-16 | 2000-08-29 | Terumo Corp | Blood component measuring device and blood component measuring method |
| CN1419651A (en) * | 2000-03-22 | 2003-05-21 | 全麦迪科斯有限责任公司 | Electrochemical biosensor test strip with recognition electrode and readout meter using this test strip |
| CN1456680A (en) * | 2002-05-10 | 2003-11-19 | 生命扫描有限公司 | Multi-layer reagent strips and method for measuring saccharfied protein in physiological samples |
| TWI281947B (en) * | 2003-07-30 | 2007-06-01 | Bing-Huei Chen | A capillary biochip and detecting device of the same |
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