CN101579374A - Medicine composition for reducing blood fat - Google Patents

Abstract

The invention relates to a medicine composition for reducing blood fat, comprising sea backthern, vitamin A, beta-renieratene, vitamin B complex, vitamin C, vitamin E and trace elements of zinc, selenium, chromium, copper, molybdenum, iodine and manganese. The composition is mainly suitable for hyperlipemia crowds, is curative for reducing blood fat, and can be used for a long time or according to the course of treatment.

Description

The pharmaceutical composition that is used for blood fat reducing

Technical field:

The present invention relates to the Medicines and Health Product technical field; Pharmaceutical composition in particular for blood fat reducing.

Background technology:

Said composition comprises Fructus Hippophae, vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin E and trace element zinc, selenium, chromium, copper, molybdenum, iodine, manganese.

Fructus Hippophae be a kind of be food be again the natural Chinese medicine of medicine, strengthening the spleen to promote digestion is arranged, expelling phlegm for arresting cough, the effect of blood circulation promoting and blood stasis dispelling; The clinical diseases such as insufficiency of the spleen lack of appetite, cough with copious phlegm, blood stasis amenorrhea, traumatic injury congestive edema that are used for the treatment of; Modern pharmacological research confirms that Fructus Hippophae has: 1, effect for reducing blood fat; 2, hepatoprotective effect; 3, antitumor action; 4, antioxidation, anti-aging effects; 5, hematopoietic cell there is facilitation; 6, reduce blood viscosity, anticoagulation, anti thrombotic action; 7, raise immunity; 8, resist myocardial ischemia, anoxia, protection myocardial function; 9. antiulcer action; 10, the antiinflammatory effect of curing the wound; 11, anti-allergic effects; 12, anti-radiation function; 13, strong body antifatigue effect; Animal saliva, gastrointestinal glandular secretion are increased, and pepsin content raises, and simultaneously the gastrointestinal motility function is had stimulation, and gastrointestinal rhythmicity contraction cycle is prolonged, and amplitude increase etc. influences the gastrointestinal function; 15, in addition can also arrhythmia, the ear poison reaction due to prevention and the antagonism gentamycin.

Vitamin A also claims retinol, the effect that improves vision, prevents nyctalopia is arranged, participate in glycogen and proteinic synthetic, can promote mucopolysaccharide synthetic, influence renewal, the growth of osseous tissue, long bone is grown to both-end, beta-carotene can change vitamin A under the effect of enzyme in vivo, the effect of performance vitamin A, beta-carotene has the effect that suppresses LDL cholesterol oxidation reaction with vitamin E, vitamin C in the mode of cooperative compensating.

Vitamin B group participates in body internal protein, fat and sugar metabolism, makes the excitement of brain cell and inhibition be in poised state, and it comprises vitamin B ₁, vitamin B ₂, nicotiamide, pantothenic acid, biotin, vitamin B ₆, vitamin B ₁₂, folic acid etc., collaborative in vivo performance physiological action.Vitamin B ₁Participate in body internal protein, fat, breakdown of carbohydrates metabolism and anabolism, can show vitamin B1 deficiency during shortage is the various dysbolismus of representative, vitamin B in addition ₁Also participate in the neural impulse reaction, keep myocardium normal function, keep normal appetite, gastrointestinal peristalsis and digestive juice secretion etc.; Vitamin B ₂Have another name called riboflavin, it is the ingredient of many important coenzyme in the body, participate in intravital substance metabolism, guarantee that vivo oxidation reduction reaction and energy generate, participate in anti-oxidative defense system in the body, mainly show oral cavity reproductive system syndrome, retardation of growth, iron deficiency anemia, moisture dermatitis, minimizing erythropoiesis, the systemic-function that affects the nerves, the vision etc. that reduces during shortage; Nicotiamide claims niacin amide or vitamin PP again, and its physiological function is to participate in the body intracellular metabolic, keeps normal neurological function, and pellagra can take place during shortage in synthesizing of assurance gonadal hormone etc., mainly shows as dermatitis, diarrhoea, dull-witted three big symptoms; Pantothenic acid extensively exists in each organism, participates in metabolic activity widely, and known have 70 plurality of enzymes all to need pantothenic acid to participate in all kinds of biochemical reaction of catalysis body, otherwise just can Metabolic disorder; Biotin also is a kind of vitamin B group, coordinates to participate in the metabolism of human body matter and energy with other vitamin B group, and it is synthetic with nucleic acid, and the compositive relation of gonadal hormone is close, and it also has control poliosis, bareheaded effect; Vitamin B ₆Play the coenzyme effect of transaminase, amino acid decarboxylases in vivo, guarantee the metabolism of materials such as aminoacid, glycogen, fatty acid and one carbon unit, nicotinic acid, guarantee the normal propagation of nucleic acid and proteinic synthetic and cell, guarantee homergy with neurotransmitteies such as a hydroxytryptamine, taurine, dopamine, guarantee normal immunologic function, immunity degradation during shortage also can cause neural infringement; Vitamin B ₁₂Participate in nucleic acid in vivo, choline, amino acid whose synthetic and fat and sugared metabolism, to hemopoietic function of bone marrow, the gastrointestinal epithelial cells function, liver function and nervous system myelin functional integrity have certain effect, it is the necessary vitamin of intelligence of bringing into normal play, not only cause dysnoesia if lack, also nutritional anemia can occur, influence is to blood supply in the brain; Folic acid participates in the synthetic of aminoacid and nucleic acid, and and vitamin B ₁₂The common generation that promotes cell is with ripe, and normal cell can not carry out mitosis during shortage, the neurological symptom can occur, as: the loss of memory, depression and dementia etc.;

Vitamin C claims ascorbic acid again, vitamin C and collagen in close relations, the vessel softening effect is not only arranged, and the effect that purifies the blood in addition prevents arteriosclerosis, in cholesterol metabolism, play an important role, can effectively reduce neutral fat, can also promote the absorption of human body, for hemopoietic provides essential raw material ferrum in the food, simultaneously, vitamin C regain one's strength, aspect effect such as allaying tiredness, keeping tensions down emotion is obvious;

Vitamin E is all general designations with the bioactive chromone derivative of alpha-tocopherol, and wherein the activity of alpha-tocopherol is the highest, has antioxidation, avoids the effect of biomembrane generation lipid peroxidation; Stop the effect of LDL oxidation formation, thereby prevent the generation of atherosclerosis and cardiovascular disease; Also have to regulate immunity, slow down aging, inhibition tumor in addition, promote fetal development and reproductive performance to reach the protective effect of nerve and skeleton etc.

Trace element zinc is merged in the biomacromolecule ligand---in protein, nucleic acid, the film (being mainly memebrane protein), generate stable metallic biomacromolecule complex---metalloprotein, metalloproteinase nucleic acid complex etc., at present, known these materials participate in the synthetic and degradation process of carbohydrate, lipid, protein and nucleic acid, and the existence of zinc enzyme is all arranged in six big fermentoids; Zinc also is the essential element of enhance immunity vigor; Zinc can promote that proinsulin is converted into insulin by activating protaminase, and zinc deficiency makes insulin be obstructed in the activity of peripheral tissues, and it is unusual to cause glucose tolerance curve.

Trace element-selenium has obvious reduction serum total cholesterol, triglyceride and lipid peroxide, improves high density lipoprotein, the metabolic effect of superabundant fats in the acceleration bodies; Selenium also has the strong anti-oxidation function, and the protection embryo is not subjected to the injury of superoxides, prevention of cardiac; Anticancer by enhance immunity recognition system removing cancerous cell; Remove and the drainage heavy metal ion, hydrargyrum, methyl mercury, cadmium, lead etc. are had Detoxication, and heavy metal pollution is mainly to cause the birth defect factor; Scarce selenium can make the human insulin secretion reduce, impaired glucose tolerance, and oxidation resistance descends and quickens human senility and intelligence decline.

Chromium is insulin " collaborative hormone ", to have the effect of active organochromium compounds " glucose tolerance factor (GTF) " form enhancing insulin, mainly be to keep normal carbohydrate metabolism of body and lipid metabolism, following symptom can occur when not enough: weaken glucose tolerance, increase the weight of hyperglycemia, glucose in urine, hypoglycemia, the circulation of acceleration insulin, reduce Insulin receptor INSR quantity, reduce the insulin binding ability, lose weight, increase fat content, increase vision pressure etc.The chromium of two kinds of valence states of stable existence in the environment, i.e. trivalent chromium and Cr VI, trivalent chromium has physiologically active, uses useful and harmlessly in an amount of scope, and Cr VI is a kind of strong oxidizer, and human body is had toxic and side effects.

Copper is the active component of 30 plurality of enzymes such as lysyl oxidase in the body, cytochrome oxidase, monoamine oxidase, MAO, participates in the redox reaction of cell.When lacking copper, 7 α-hydroxyl enzyme and 12 α-hydroxylase activity that the catalysis cholesterol changes cholic acid into reduce, and cholesterol is synthetic and eliminate minimizing, and cholesterol is discharged and is obstructed, and causes hyperlipemia.Absolute or relative copper lacks can make serum TC, TG level raise, and causes high-cholesterol disease.

Molybdenum is one of micro elements needed by human, it is the formation element of plurality of enzymes, participate in the utilization of ferrum, promote erythrocytic growth and maturation, can prevent anemia, and can help the metabolism of carbohydrate and fat, it participates in removing the murder by poisoning of poisonous aldehydes in the human body, eliminate human free radical, have anticancer, defying age, enhancing immunity and anticariogenic function; Scarce molybdenum can bring out cardiovascular disease, cancer and dental caries.

Iodine is the main synthetic thyroid element that participates in human body, and thyroxinic physiological function is to regulate the organism metabolism level, influences the generation of body heat energy, blood glucose and ketoboidies level, muscle and nervous, many-sided functions such as body weight, intelligence and sexual function; Adult's iodine deficiency can cause thyromegaly.

Manganese participates in the formation of some enzymes in human body, it is the metabolism of involved in sugar and lipid not only, and all works in protein, DNA and RNA are synthetic.

Application contains Fructus Hippophae, vitamin A, beta-carotene, vitamin B ₁, vitamin B ₂, vitamin B ₆, nicotiamide, pantothenic acid, biotin, vitamin B ₁₂, folic acid, vitamin C, vitamin E and trace element zinc, selenium, chromium, copper, molybdenum, iodine, manganese has been known as the compositions of active component, but with Fructus Hippophae, vitamin A, beta-carotene, vitamin B ₁, vitamin B ₂, nicotiamide, pantothenic acid, biotin, vitamin B ₆, vitamin B ₁₂, folic acid, vitamin C, vitamin E and trace element zinc, selenium, chromium, copper, molybdenum, iodine, the manganese compatibility pharmaceutical composition report as yet that is used for blood fat reducing.

Current medicine that is used for blood fat reducing or health food kind have multiple, but have the medicine of side effect more, and the health food target spot is few, the link shortcoming, need perfect, and cost height, price height.

Summary of the invention:

In order to overcome the shortcoming and defect of existing blood fat reducing medicine, the purpose of this invention is to provide a kind of compositions, said composition is by collaborative vitamin A, beta-carotene, the vitamin B of increasing of Fructus Hippophae ₁, vitamin B ₂, nicotiamide, pantothenic acid, biotin, vitamin B ₆, vitamin B ₁₂, folic acid, vitamin C, vitamin E and trace element zinc, selenium, chromium, copper, molybdenum, iodine, manganese blood fat reducing effect, simultaneously by trace element zinc, selenium, chromium, copper, molybdenum, iodine, manganese and vitamin A, beta-carotene, vitamin B ₁, vitamin B ₂, nicotiamide, pantothenic acid, biotin, vitamin B ₆, vitamin B ₁₂, folic acid, vitamin C, vitamin D, vitamin E, replenish and strengthen the effect of Fructus Hippophae blood fat reducing, even chronic administration is also without any side effect; Because the result of broad research, the inventor has found Fructus Hippophae, vitamin A, beta-carotene, vitamin B ₁, vitamin B ₂, nicotiamide, pantothenic acid, biotin, vitamin B ₆, vitamin B ₁₂, folic acid, vitamin C, vitamin E and trace element zinc, selenium, chromium, copper, molybdenum, iodine, manganese novel combination, this novel combination has synergy for blood fat reducing; And single with Fructus Hippophae, vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin E and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese, its effect is all not as good as this compositions; There is not incompatibility in this compositions, have no side effect, and cost is low, thereby constitutes the present invention.

The invention provides the pharmaceutical composition that is used for blood fat reducing, it comprises Fructus Hippophae, vitamin A, beta-carotene, vitamin B as active component ₁, vitamin B ₂, nicotiamide, pantothenic acid, biotin, vitamin B ₆, vitamin B ₁₂, folic acid, vitamin C, vitamin E and trace element zinc, selenium, chromium, copper, molybdenum, iodine, manganese.

Fructus Hippophae is that the dry fruit of Elaeangnaceae machaka or dungarunga Fructus Hippophae (Hippophae rhamnoides) supplies to use; Kinds such as Fructus Hippophae thibetanae, subsp.neurocarpa, Jiangzi Fructus Hippophae, central asian sea buckthorn, mongolian seabuckthorn are arranged; Main product in the Inner Mongol, ground such as Shanxi, Shaanxi, Qinghai; The used Fructus Hippophae of the present invention can be with its extract as raw material.

Be used for vitamin B of the present invention ₁(VitaminB ₁), vitamin B ₂(VitaminB ₂), nicotiamide (Nicotinamide), pantothenic acid (Pantothenic Acid), biotin (Vitamin H), vitamin B ₆(VitaminB ₆), vitamin B ₁₂(VitaminB ₁₂), folic acid (Folic Acid), vitamin C (VitaminC), all are water soluble vitamins, do not accumulate in vivo; Vitamin A (Vitamin A), vitamin E (Vitamin E) are fatsoluble vitamiies, and beta-carotene (Beta Carotene) is the precursor substance of vitamin A, and be useful and harmless by the used dosage of the present invention; Zinc (Zn), selenium (Se), chromium (Cr), copper (Cu), molybdenum (Mo), iodine (I) are micro elements needed by human, and manganese (Mn) is human body possibility essential trace element; Trace element zinc among the present invention can be selected zinc citrate for use, zinc gluconate, zinc acetate, zinc carbonate, zinc oxide, zinc chloride, zinc lactate, zinc sulfate, single zinc methionine etc., trace element-selenium can be selected Selenomethionine for use, methoxybenzyl cyanic acid selenium, selenocarrageenan, selenocysteine, the selenizing methionine, the two cyanic acid selenium of phenylene, sodium selenite, sodium selenate etc., trace element chromium can be selected chromium trichloride for use, nicotinic acid chromium, chromium picolinate, trivalent chromiums such as chromium yeast, trace copper can be selected curpic carbonate for use, copper citrate, copper gluconate, copper sulfate etc., trace element molybdenum can be selected ammonium molybdate for use, sodium molybdate etc., trace iodine can be selected potassium iodate etc. for use, trace element manganese can be selected manganese sulfate for use, manganese chloride, manganese gluconate, manganese glycerophosphate, manganese citrates etc. all have professional production factory and supplier.

Compositions of the present invention mainly is applicable to people with hyperlipidemia, and by the present invention, the effective dose of Fructus Hippophae is counted 300-10000mg/ days with whole crude drug, vitamin B ₁Effective dose be 0.520mg/ days, vitamin B ₂Effective dose be 0.5-20mg/ days, the effective dose of nicotiamide is 5-50mg/ days, the effective dose of pantothenic acid is 2-20mg/ days, the effective dose of biotin is 0.01-0.1mg/ days, vitamin B ₆Effective dose be 0.5-10mg/ days, vitamin B ₁₂Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, ascorbic effective dose is 30-500mg/ days, the effective dose of vitamin A and/or beta-carotene (in retinol equivalent) is 250-800 μ gRE/ days; The effective dose of vitamin E (in the alpha-tocopherol equivalent) is 5-150mg α-TE/ days, the effective dose of trace element zinc is counted 5-20mg/ days with element zinc, selenic effective dose is counted 0.015-0.1mg/ days with elemental selenium, the effective dose of chromium is counted 0.015-0.15mg/ days with elemental chromium, the effective dose of copper is counted 0.5-1.5mg/ days with elemental copper, molybdenic effective dose is counted 0.02-0.06mg/ days with molybdenum, the effective dose of iodine is counted 0.05-0.2mg/ days with elemental iodine, and the effective dose of manganese is counted 1-3mg/ days with element manganese.

Compositions of the present invention can or directly be taken by following pharmaceutical dosage forms dispenser, for example, oral formulations is (as granule, powder, capsule, ball, sheet, dry syrup, liquid formulation), or food such as food (as cookies), mix and prepare with other known additives, this class additive is for example: carrier, disintegrating agent, slow releasing agent, excipient, filler, covering, binding agent, lubricant, antioxidant, apply agent, coloring agent, correctives, sweeting agent, sucrose succedaneum, nutrition enhancer, flavouring agent, surfactant, plasticizer, the PH regulator, freshener, suspending agent, defoamer, antiseptic, thickening agent, solubilisation aids etc. are prepared or they are added food as functional component or additive by usual way.

By the present invention, Fructus Hippophae, vitamin A, beta-carotene, vitamin B ₁, vitamin B ₂, nicotiamide, pantothenic acid, biotin, vitamin B ₆, vitamin B ₁₂, folic acid, vitamin C, vitamin E and trace element zinc, selenium, chromium, copper, molybdenum, iodine, manganese each component can distinguish preparation, the preparation of each component can be mixed the back when using and use or do not mix simultaneously and use.

Advantage of the present invention be this compositions from too many levels, multisystem, many target spots blood fat reducing, the effect of collaborative performance effect is arranged between the each component, blood fat reducing is had significant effect, sufficient raw, cost is low, and each component has no side effect in the compositions, no incompatibility.

Subordinate list 1 causes diabetes model rat blood fat reducing test effect relatively for this compositions and Fructus Hippophae component and vitamin added elements component to (STZ).

Relatively tabulate below with reference to embodiment and test implementation example effect and to be described in detail the present invention.

Embodiment 1:

Fructus Hippophae 500mg,

Vitamin B ₁3mg,

Vitamin B ₂3mg,

Vitamin B ₆2mg,

Folic acid 0.3mg,

Vitamin B ₁₂0.003mg,

Nicotiamide 10mg,

Vitamin C 30mg,

Zinc lactate (in trace element zinc) 10mg,

Sodium selenate (in trace element-selenium) 0.02mg,

Chromium picolinate (in trace element chromium) 0.05mg,

Potassium iodate (in trace iodine) 0.1mg,

Retinol equivalent (vitamin A and/or beta-carotene) 300 μ gRE,

Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.

Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.

Embodiment 2:

Fructus Hippophae 800mg,

Vitamin B ₁3mg,

Vitamin B ₂3mg,

Vitamin B ₆2mg,

Folic acid 0.3mg,

Vitamin B ₁₂0.003mg,

Nicotiamide 10mg,

Vitamin C 30mg,

Zinc lactate (in trace element zinc) 8mg,

Sodium selenate (in trace element-selenium) 0.02mg,

Chromium picolinate (in trace element chromium) 0.03mg,

Sodium molybdate (in trace element molybdenum) 0.03mg,

Potassium iodate (in trace iodine) 0.1mg,

Retinol equivalent (vitamin A and/or beta-carotene) 300 μ gRE,

Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.

Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.

Embodiment 3:

Fructus Hippophae 1200mg,

Vitamin B ₁3mg,

Vitamin B ₂3mg,

Vitamin B ₆2mg,

Folic acid 0.3mg,

Vitamin B ₁₂0.003mg,

Nicotiamide 10mg,

Vitamin C 30mg,

Zinc lactate (in trace element zinc) 10mg,

Sodium selenate (in trace element-selenium) 0.02mg,

Chromium yeast (in trace element chromium) 0.02mg,

Copper citrate (in trace copper) 0.8mg,

Sodium molybdate (in trace element molybdenum) 0.03mg,

Potassium iodate (in trace iodine) 0.1mg,

Retinol equivalent (vitamin A and/or beta-carotene) 300 μ gRE,

Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.

Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.

Embodiment 4:

Fructus Hippophae 2000mg,

Vitamin B ₁3mg,

Vitamin B ₂3mg,

Vitamin B ₆2mg,

Folic acid 0.3mg,

Vitamin B ₁₂0.003mg,

Nicotiamide 10mg,

Vitamin C 30mg,

Zinc lactate (in trace element zinc) 10mg,

Sodium selenate (in trace element-selenium) 0.02mg,

Chromium yeast (in trace element chromium) 0.02mg,

Copper citrate (in trace copper) 0.8mg,

Sodium molybdate (in trace element molybdenum) 0.03mg,

Potassium iodate (in trace iodine) 0.1mg

Manganese citrate (in trace element manganese) 1mg,

Retinol equivalent (vitamin A and/or beta-carotene) 300 μ gRE,

Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.

Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn.

Embodiment 5:

Fructus Hippophae 3000mg,

Vitamin B ₁3mg,

Vitamin B ₂3mg,

Vitamin B ₆2mg,

Folic acid 0.3mg,

Vitamin B ₁₂0.003mg,

Nicotiamide 10mg,

Pantothenic acid 6mg,

Vitamin C 30mg,

Zinc lactate (in trace element zinc) 10mg,

Sodium selenate (in trace element-selenium) 0.02mg,

Chromium yeast (in trace element chromium) 0.02mg,

Copper citrate (in trace copper) 0.8mg,

Sodium molybdate (in trace element molybdenum) 0.03mg,

Potassium iodate (in trace iodine) 0.1mg

Manganese citrate (in trace element manganese) 1mg,

Retinol equivalent (vitamin A and/or beta-carotene) 300 μ gRE,

Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.

Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn.

Embodiment 6:

Fructus Hippophae 300mg,

Vitamin B ₁0.5mg,

Vitamin B ₂0.5mg,

Vitamin B ₆0.5mg,

Folic acid 0.1mg,

Vitamin B ₁₂0.001mg,

Nicotiamide 5mg,

Pantothenic acid 2mg,

Biotin 0.01mg,

Vitamin C 30mg,

Zinc lactate (in trace element zinc) 5mg,

Sodium selenate (in trace element-selenium) 0.015mg,

Chromium yeast (in trace element chromium) 0.015mg,

Copper citrate (in trace copper) 0.5mg,

Sodium molybdate (in trace element molybdenum) 0.02mg,

Potassium iodate (in trace iodine) 0.05mg,

Manganese citrate (in trace element manganese) 1mg,

Retinol equivalent (vitamin A and/or beta-carotene) 250 μ gRE,

Vitamin E (in the alpha-tocopherol equivalent) 5mg α-TE.

Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn.

Embodiment 7:

Fructus Hippophae 10000mg,

Vitamin B ₁20mg,

Vitamin B ₂20mg,

Vitamin B ₆10mg,

Folic acid 1mg,

Vitamin B ₁₂0.025mg,

Nicotiamide 50mg,

Pantothenic acid 20mg,

Biotin 0.1mg,

Vitamin C 500mg,

Zinc lactate (in trace element zinc) 20mg,

Sodium selenate (in trace element-selenium) 0.1mg,

Chromium yeast (in trace element chromium) 0.15mg,

Copper citrate (in trace copper) 1.5mg,

Sodium molybdate (in trace element molybdenum) 0.06mg,

Potassium iodate (in trace iodine) 0.2mg,

Manganese citrate (in trace element manganese) 3mg,

Retinol equivalent (vitamin A and/or beta-carotene) 800 μ gRE,

Vitamin E (in the alpha-tocopherol equivalent) 150mg α-TE.

Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn, serve on 7, withdrew 3, obeyed again 7.

Confirm that through animal experiment this compositions belongs to nontoxic level; The crowd takes and does not also see toxicity.

Embodiment 8: this compositions causes diabetes model rat blood fat reducing test effect relatively with each component to (STZ).

Selecting SD is 48 feeds of male rat high lipid food, press an intraperitoneal injection STZ of 25mg/kg body weight (streptozotocin) after raising for 4 weeks, fasting is after 8 hours after 2 weeks, gavage the 20%D-glucose solution by the 2g/kg body weight, do the oral glucose tolerance test, all 0 and 2 hour blood glucose is respectively greater than 7.0 and the rat of 11.0mmol/L, as diabetes modeling success rat.Modeling success rat is divided into 4 groups at random, 12 every group, is respectively matched group (A group), the B group, C group, D group, test is respectively organized distilled water suspension oral gavage that every day, per os gave checking matter and equivalent once, matched group gives equivalent normal saline filling stomach once every day, in administration 12 week back fasting on the 3rd 10 hours, carotid artery blood sampling, measure T-CHOL respectively, triglyceride, high density lipoprotein, three indexs.

Related data sees attached list 1.

Subordinate list 1: this compositions causes diabetes model rat blood fat reducing test effect relatively with Fructus Hippophae component and vitamin added elements component to (STZ):

From table 1, can obviously find out, take this composite preparation and take Fructus Hippophae component and vitamin added elements component contrast high blood lipid model rat blood fat reducing test effect the difference of highly significant is arranged.

Claims (6)

1, a kind of pharmaceutical composition that is used for blood fat reducing is characterized in that it is made by weight ratio by following raw materials according:

Fructus Hippophae 300-10000mg,

Vitamin B ₁0.5-20mg,

Vitamin B ₂0.5-20mg,

Vitamin B ₆0.5-10mg,

Folic acid 0.1-1mg,

Vitamin B ₁₂0.001-0.025mg,

Nicotiamide 5-50mg,

Pantothenic acid 0-20mg,

Biotin 0-0.1mg,

Vitamin C 30-500mg,

Zinc 5-20mg,

Selenium 0.015-0.1mg,

Chromium 0.015-0.15mg,

Copper 0-1.5mg,

Molybdenum 0-0.06mg,

Iodine 0.05-0.2mg,

Manganese 0-3mg,

Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ gRE,

Vitamin E 5-150mg a-TE.

2, the pharmaceutical composition that is used for blood fat reducing according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:

Fructus Hippophae 300-10000mg,

Vitamin B ₁0.5-20mg,

Vitamin B ₂0.5-20mg,

Vitamin B ₆0.5-10mg,

Folic acid 0.1-1mg,

Vitamin B ₁₂0.001-0.025mg,

Nicotiamide 5-50mg,

Pantothenic acid 0-20mg,

Biotin 0-0.1mg,

Vitamin C 30-500mg,

Zinc 5-20mg,

Selenium 0.015-0.1mg,

Chromium 0.015-0.15mg,

Copper 0-1.5mg,

Molybdenum 0.02-0.06mg,

Iodine 0.05-0.2mg,

Manganese 0-3mg,

Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ gRE,

Vitamin E 5-150mg a-TE.

3, the pharmaceutical composition that is used for blood fat reducing according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:

Fructus Hippophae 300-10000mg,

Vitamin B ₁0.5-20mg,

Vitamin B ₂0.5-20mg,

Vitamin B ₆0.5-10mg,

Folic acid 0.1-1mg,

Vitamin B ₁₂0.001-0.025mg,

Nicotiamide 5-50mg,

Pantothenic acid 0-20mg,

Biotin 0-0.1mg,

Vitamin C 30-500mg,

Zinc 0.015-0.1mg,

Selenium 5-20mg,

Chromium 0.015-0.15mg,

Copper 0.5-1.5mg,

Molybdenum 0.02-0.06mg,

Iodine 0.05-0.2mg,

Manganese 0-3mg,

Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ gRE,

Vitamin D 0.0015-0.01mg,

Vitamin E 5-150mg a-TE.

4, the pharmaceutical composition that is used for blood fat reducing according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:

Fructus Hippophae 300-10000mg,

Vitamin B ₁0.5-20mg,

Vitamin B ₂0.5-20mg,

Vitamin B ₆0.5-10mg,

Folic acid 0.1-1mg,

Vitamin B ₁₂0.001-0.025mg,

Nicotiamide 5-50mg,

Pantothenic acid 0-20mg,

Biotin 0-0.1mg,

Vitamin C 30-500mg,

Zinc 5-20mg,

Selenium 0.015-0.1mg,

Chromium 0.015-0.15mg,

Copper 0.5-1.5mg,

Molybdenum 0.02-0.06mg,

Iodine 0.05-0.2mg,

Manganese 1-3mg,

Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ gRE,

Vitamin E 5-150mg a-TE.

5, the pharmaceutical composition that is used for blood fat reducing according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:

Fructus Hippophae 300-10000mg,

Vitamin B ₁0.5-20mg,

Vitamin B ₂0.5-20mg,

Vitamin B ₆0.5-10mg,

Folic acid 0.1-1mg,

Vitamin B ₁₂0.001-0.025mg,

Nicotiamide 5-50mg,

Pantothenic acid 2-20mg,

Biotin 0-0.1mg,

Vitamin C 30-500mg,

Zinc 5-20mg,

Selenium 0.015-0.1mg,

Chromium 0.015-0.15mg,

Copper 0.5-1.5mg,

Molybdenum 0.02-0.06mg,

Iodine 0.05-0.2mg,

Manganese 1-3mg,

Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ gRE,

Vitamin E 5-150mg a-TE.

6, the pharmaceutical composition that is used for blood fat reducing according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:

Fructus Hippophae 300-10000mg,

Vitamin B ₁0.5-20mg,

Vitamin B ₂0.5-20mg,

Vitamin B ₆0.5-10mg,

Folic acid 0.1-1mg,

Vitamin B ₁₂0.001-0.025mg,

Nicotiamide 5-50mg,

Pantothenic acid 2-20mg,

Biotin 0.01-0.1mg,

Vitamin C 30-500mg,

Zinc 5-20mg,

Selenium 0.015-0.1mg,

Chromium 0.015-0.15mg,

Copper 0.5-1.5mg,

Molybdenum 0.02-0.06mg,

Iodine 0.05-0.2mg,

Manganese 1-3mg,

Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ gRE,

Vitamin E 5-150mg a-TE.