CN101579361B - Complex probiotics for curing hypertension and coronary heart disease and preparation method thereof - Google Patents
Complex probiotics for curing hypertension and coronary heart disease and preparation method thereof Download PDFInfo
- Publication number
- CN101579361B CN101579361B CN2009100649980A CN200910064998A CN101579361B CN 101579361 B CN101579361 B CN 101579361B CN 2009100649980 A CN2009100649980 A CN 2009100649980A CN 200910064998 A CN200910064998 A CN 200910064998A CN 101579361 B CN101579361 B CN 101579361B
- Authority
- CN
- China
- Prior art keywords
- heart disease
- coronary heart
- bacillus
- preparation
- cholesterol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a complex probiotics for curing hypertension and coronary heart disease and a preparation method thereof, the complex probiotics can also be prepared by the following strains according to proportioning by weight: the proportions of Lactobacillus bulgaricus, bifidobacteria and Lactobacillus reuteri are respectively 1-5, 1-4 and 3-7; wherein, the viable contents are all 1.8-2.6 billion/ml. By replenishing probiotics in the invention, the micro-ecological balance of intestinal tracts can be adjusted and meanwhile the change of cholesterol preparation mechanism of human body is triggered, then low density lipoprotein (LDL) in human blood vessel is quickly removed so that thrombus is fast dissolved and new thrombus is difficult to form, thus reaching the aims of curing coronary heart disease and reducing the blood pressure.
Description
Affiliated technical field
The technology that the present invention relates to utilize compound probiotic that hypertension and coronary heart disease are improved, be specifically related to a kind of compound probiotic for the treatment of hypertension and coronary heart disease and preparation method thereof, the present invention utilizes additional compound probiotic can regulate the interior microecological balance of intestinal, and cause the intravital cholesterol of people and allocate the variation of mechanism, thereby effectively reduce body inner cholesterol content, thereby effectively blood pressure lowering is treated coronary heart disease simultaneously.
Background technology
Coronary heart disease (CHD) is to be caused by the coronary atherosclerosis in the heart.It is modal a kind of heart disease, and about more than 700 ten thousand Americans suffer from this disease, and what is worse, no matter be concerning women or male, it all is No.1 killer.The heart attack that has every year more than 50 ten thousand Americans to die and cause in coronary heart disease.
Most of this death is avoidable, because coronary heart disease is relevant with life style.The common risk factor of coronary heart disease---hypertension, hypercholesterolemia, smoking, obesity, physical exertion deficiency, diabetes and pressure, these all can be controlled.In general, hypertension, hypercholesterolemia or smoking meeting make ill probability increase several times.Therefore, people who has these three kinds of risk factors probability of suffering from this disease equals 8 times without any the people of risk factor.Obesity can promote hypercholesterolemia and hypertensive probability, and can increase the danger of heart attack.
Some other risk factor just can not have been controlled, as heredity, age and sex.Heredity relates to the problem of several respects, and one of them is exactly that the race divides.The African American suffers from serious hypertension than European descendants American is easier, thus they suffer from the danger of coronary heart disease will be higher.It is also higher that the Hawaiians in chicano, American Indians, native country and part Asian American suffer from the danger of coronary heart disease.Partly cause is obesity disease and the diabetes among these ethnic populations.It is double that other family's features also can make people suffer from the probability of coronary heart disease.For example, on the person of the family history that much is ill with heart disease, can both find one or more risk factors, as hypertension or hypercholesterolemia.
Age and sex also are uncontrollable risk factors.Coronary heart disease took place along with the time, that is to say, this danger raises along with the growth at people's age.4/5 the people who dies from coronary heart disease is at over-65s (comprising 65 years old).Compare with the man, elderly woman is easier die in several weeks of heart attack.Even like this, cardiopathic probability takes place still than women height in the male, and the time of outbreak can compare early.
Want to understand the cause of coronary heart disease, must understand heart earlier and how to work.As all muscle, heart needs continuous oxygen and nutrition supply equally, and these things are all brought heart into by coronary artery.When CAN or obturation, they just can not be the enough blood of heart supply, and this situation can cause following several consequence.
If lacked oxygen containing blood in the heart, its reaction may be a pain, just our angina pectoris of saying.When blood supply is cut off fully, when being exactly heart attack.In case such situation takes place, can not get that part of will the dying that oxygen is supplied with in the heart, the part muscle in the heart may suffer permanent damage.
The thickening of coronary artery inwall is called as " arteriosclerosis ", when containing higher cholesterol level in a people's the blood, usually arteriosclerosis can take place.In blood circulation, cholesterol and fat have constituted the arterial blood tube wall, make them become narrow, thereby slow down even the occlude blood circulation.When the cholesterol level in the blood was higher, it more likely was deposited on the arterial blood tube wall.This process just began in a lot of people's childhood and juvenile period, and along with the age is big more, situation is more and more serious.
What is a cholesterol? in simple terms, cholesterol is exactly a kind of molecule, and health as a kind of building blocks, is used for producing other chemical combination materials to it.Cholesterol is the indispensable material of human body, and it is one of composition member of cell membrane, and is relevant with biomembranous permeability and nerve conduction, is again simultaneously the precursor substance that forms steroid hormone, bile acid and synthesis of vitamin d.About cholesterol, always see a lot of abbreviations, as HDL (high density lipoprotein), LDL (low density lipoprotein, LDL) and HDL/LDL (ratios of these two kinds of lipoproteins).HDL is good cholesterol, and LDL is bad cholesterol.Bad cholesterol can block your tremulous pulse, makes it to become hard and narrow.This is only the very crux.In case tremulous pulse loses flexibility, blood pressure will raise, and best blood and nutrient substance just can not arrive that each position of health---body muscle and heart also all can harden.
The simplest coronary heart disease signal is exactly chest pain and short of breath.That people's thoracic cavity may be felt is heavy, tight, pain, as burning, pressure is arranged or constriction is arranged.The perception position is the breastbone back normally, sometimes also can be arm, cervical region or chin.In case these signals occurred, people just should go to have seen the doctor.However, some person is gone up performance and is not gone out any sign, can only could find after heart attack.What deserves to be mentioned is that the women may be especially strange to those coronary heart disease signals that are specific to them, in addition premorbid all imperceptible they.
When conventional chemical Drug therapy coronary heart disease and hypertension, be mitigation, be difficult to radical cure.Simultaneously, medicine produces very big side effect to human body itself.
Summary of the invention
Therefore still there is demand in human material to the better blood pressure lowering of curative effect, treatment coronary heart disease, up to now, also do not find any relevant report of the present invention, the inventor is through research repeatedly, finally find the blood pressure lowering of better efficacy, the material of treatment coronary heart disease, finished the present invention.The object of the invention provides and a kind ofly has no side effect, treating both the principal and secondary aspects of a disease, can more effective blood pressure lowering, the treatment hypertension of treatment coronary heart disease and the compound probiotic of coronary heart disease.
Another object of the present invention provides the preparation method of this compound probiotic.
The consumption that compound probiotic of the present invention is formed is that inventor's process gropes to sum up to get for a long time in a large number, and the each component consumption all has curative effect preferably at following weight proportion:
The proportioning of bulgaricus bacillus, bacillus bifidus and Lactobacillus reuteri is respectively 1-5,1-4 and 3-7, and wherein their viable bacteria content is 18-26 hundred million/milliliter.
The preparation method of compound probiotic of the present invention is as follows:
1), bulgaricus bacillus, bacillus bifidus and Lactobacillus reuteri are mixed according to described proportioning, putting into by Semen Maydis powder 6-14%, peptone 3-7%, glucose 6-14% and surplus is to cultivate in the culture medium of pure water;
2), above-mentioned strain was got final product at 20-24 ℃ of bottom fermentation 10-14 days in above-mentioned culture medium.
1), suppress deleterious antibacterial and noxious substance in the present invention, Lactobacillus bulgaricus has following therapeutic effect:, protected health.2), suppress the pathogenic bacterium in the intestinal and the breeding of putrefaction bacteria, drink yoghourt after, the escherichia coli in the feces, perfringens fusiform bacteria quantity reduce, and produce oligosaccharide, improve relieving constipation, shorten the time of feces in large intestine.Lactic acid and acetic acid that lactic acid bacteria fermentation produces have bactericidal action, and can also produce hydrogen peroxide (H
2O
2), bacteriostasis is arranged; Can also produce multiple antibiotics, these antibiotics have antagonism to Salmonella, shigella, staphylococcus, aerobic bud pole bacterium, fusiform bacteria, pseudomonas etc.3), the effect that reduces blood cholesterol is arranged; High-cholesterol diet but drink in a large number in the nationality of yoghourt simultaneously on the feed, its blood cholesterol level is not high.4), has antitumaous effect.Mainly be because the intestinal microbial population situation is improved, suppressed the carcinogen generation, the content of indole and phenol in the reduction intestinal; Activated immunologic function, anticancer propagation.In addition, after self-insurance markon subfamily scholar Bogdanor husband reports the effect that yoghourt has direct anticancer, constantly the someone studies, and finds in experiment, and the yoghourt of Lactobacillus bulgaricus, bacillus acidophilus, streptococcus thermophilus fermentation all has inhibitory action to the intravital cancerous cell of laboratory animal.
1), safeguard intestinal normal bacteria colony balance bacillus bifidus has following therapeutic effect:, suppress growth of pathogenic bacteria, prevent constipation, dysentery and gastrointestinal disorders etc.; 2), antitumor; 3), in intestinal synthetic vitamin, aminoacid and raising body to the absorption of calcium ion; 4), reduce cholesterol levels in the blood, prevent and treat hypertension; 5), improve the anti-lactose of milk product, improve digestibility; 6), strengthen the human immunologic function, prevent antibiotic side effect, defying age, life lengthening.
Lactobacillus reuteri can also improve body immunity fast except having above two kinds of probiotic effect, simultaneously, its tunning provides substrate (food) for other two kinds of mutual probiotic bacterias, thereby makes that three kinds of probiotic bacterias can symbiosis.
Using probiotic bacteria is just approved recently a kind of method of controlling cholesterol.Although people know that for a long time yoghourt and some common probiotic bacterias of edible fermentation can cholesterol reducing.But the more than ten years scientists just begins to study up to date.
Scientists is found in to the research of cholesterol and probiotic bacteria, when a large amount of probiotic bacterias is used--every dose of organism that contains more than 100 ten thousand work--cholesterol in the blood will reduce.The more important thing is that they find that also the ratio of HDL and LDL can increase.Compare with LDL, the content of HDL is many more, and this ratio is high more.
Why is this point very important? if LDL is regarded clogged material, HDL just can be imagined as the material of cleaning deposit so.As noted earlier, LDL is likened into Lego, by adapter multiple cholesterol molecule is connected together.LDL assembles in tremulous pulse, piles up one by one, blocks circulation gradually.And HDL is just as the Lego that does not contain adapter.Same, because HDL can not be strapped on other materials, they will produce a kind of " bowling " effect, can both smash LDL, no matter where they form.So if the content of HDL exceeds the many more of LDL, the quantity of LDL is just few more.Reason is very simple, and HDL and LDL common (being not physically in number) have formed the cholesterol total amount.
These benefits have been arranged, and probiotic bacteria has obtained higher evaluation and attention.The probiotic bacteria of this class of picture lactobacillus acidoilus (LA), every dose contains 10,000,000,000～1,000 hundred million organisms, and they can reduce serum cholesterol greatly.Recently, some other antibacterial also has been put into range of observation, as Lactobacillus reuteri (LR).Different with the probiotic bacteria of some other kind, people only need use less LR just can receive the effect of good cholesterol reducing.
If think cholesterol reducing better, under probiotic bacteria just must be survived in by the process of intestinal absorption.Why is this? reason is: after probiotic bacteria was eaten in the body, they can enter stomach, if but they can not resist gastric acid, will be eliminated by gastric acid.In fact, most of probiotic bacteria all can be killed like this.Then, the probiotic bacteria that survives can enter intestinal, and they can run into another formidable opponent there, and that is exactly a bile.Bile has a lot of functions, and wherein a kind of is exactly sterilization.So if probiotic bacteria can not be resisted gastric acid or bile, they are just survived less than having brought into play that time of beneficial effect.
Need not be afraid of that mankind itself's function can cooperate the probiotic bacteria of survival just.Except obtaining cholesterol from food, health also can produce the cholesterol (reason that why dietary adjustments can not be proved effective always that Here it is, and in a single day it prove effective, effect then can be close to the best) of oneself.Health has produced cholesterol, has also produced a lot of other things simultaneously, and one of them is exactly a bile.Bile forms in liver, is stored in the gallbladder, is secreted to enter intestinal, facilitating digestion.The topmost work of bile is exactly chyle fat.After finishing the work, bile is reuptaked into intestinal, and finds its approach to get back in the gallbladder, waits for being used next time.
Production is catabiotic as the chemical compound of cholesterol and this class of bile.So health likes carrying out as much as possible recirculation.This also is an evolution results.
In entering the process of intestinal, bile can meet with two kinds of destiny: it can continue the work (facilitating digestion fat) of oneself, is perhaps decomposed by a process that is called " the early stage decomposition ".This is how to take place unimportant.Importantly, probiotic supplemented can be regulated the little ecology of the intestines and stomach, thereby quickens biliary early stage decomposition.If bile is decomposed, it is excreted external with regard to very possible and other refuses together.Though have some multiple absorption, measure very little.
If it is external that bile is excreted, it obviously can not be repeated to absorb again and circulation and making enters in the gallbladder.And gallbladder need keep a certain amount of bile.If make the bile that enters gallbladder descend--this is that probiotic bacteria is in the active result of enteral--so because lacking circulation, liver will be felt the decline of bile content, and reacts automatically, secretes more bile.
In order to produce more bile, health begins to transfer its cholesterol deposit.Cholesterol will be left under order from blood gradually, enters liver and produces bile.This effect is significant, also is measurable.
It more than is the mechanism of action that probiotic bacteria reduces body inner cholesterol content.A kind ofly can resist gastric acid and biliary probiotic bacteria is just better if find.Verified, LR is this acid-resisting and the stronger material of anti-bile just.It can survive in the route in entering the intestines and stomach, and there, it siphons away bile and decompose them beginning, and bile excretion goes out health the most at last.Through observing, LR can make T-CHOL reduce by 38%.
" one to one " rule is arranged, the allegedly every reduction by 1% of serum cholesterol, the probability that human body is suffered from coronary heart disease will reduce by 2%.Remember that we can reduce by 38% cholesterol now, that is to say that use the LR probiotic bacteria to reduce at least 76% to the risk of suffering from coronary heart disease, this is only emphasis.
Scientist Man En and Si Poli have found the effect of probiotic bacteria to cholesterol in African clan.They find that African Masai drinks the milk product by lactobacillus ferment in a large number, and serum cholesterol content is generally lower in its body.1977, it is also lower that they find often to drink in U.S.'s human body of yoghourt serum cholesterol content again.This has caused the concern of world nutrition educational circles, medical circle, microorganism educational circles, thereby has started the research climax of probiotic bacteria cholesterol reducing effect.
The metabolism research group of Kentucky, USA university medical research center has carried out two correlational studyes: by taking in different probiotics yogurts every day, back crowd's Blood Lipid is taken in test then.First research is at the yoghourt that contains profitable probliotics (bacillus acidophilus), and the result shows that the cholesterol concentration of taking in crowd's serum has reduced 2-4%.Used another kind of bacillus acidophilus's strain in second research, the result shows that the cholesterol concentration of taking in crowd's serum has reduced 2-3%.
The Sweden scientist thinks, taking in probiotic bacteria can hypercholesterolemia reducing and LDL cholesterol, and then reduces the danger of suffering from coronary heart disease.In the research in 1998,30 experimenters are divided into two groups.Drink 200 milliliters fruit juice first group of every day, contain 5,000 ten thousand live lactobacillus sps in every milliliter, promptly take in 1,000,000,000 probiotic bacterias every day; Another group is drunk the fruit juice that does not contain any probiotic bacteria.After 6 weeks, lineup's cholesterol levels obviously descends, and the fibrin level in the serum also has obvious decline simultaneously.Lineup's cholesterol levels and fibrin level but do not change in addition.
Probiotic therapy not only can cholesterol reducing, can also bring high blood pressure down--and this is another high risk factor that causes coronary heart disease.A lot of results show that the product that edible some lactobacillus of hyperpietic or other metabolite are made can bring high blood pressure down, and can be used as the higher instrument of patient's controlling blood pressure.
A randomized, double-blind placebo clinical research that do in Tokyo medical college Cardiovascular Center, 12 weeks by a definite date, to 39 middle aged hyperpietics (16 women, 23 male, age is between 28～81 years old) observe, observe them and drunk the blood pressure after the leben.The result shows that the lactic acid agent of single dose can obviously bring high blood pressure down.
The researcher of Japan JP Agencyof Shinshu University is also found: some probiotic bacteria can suppress to carry the again absorption of bile acid in liver of cholesterol, and has the function that the cholesterol in the blood is discharged by feces.They to one group 18～55 years old suffer from the observation that hypertensive crowd carried out reaching 8 weeks, allow wherein one group of experimenter replenish the probiotic bacteria of doses every day, the blood pressure that found that them has tangible reduction, and those matched group crowd blood pressures of not taking probiotic bacteria do not reduce.
Some researchs to fermentation milk also prove, can produce a lot of antihypertensive materials when probiotic bacteria is grown.Scientist finds to have at least a kind of situation to be because the effect of beneficial bacteria cell wall when separating the material of tool resisting hypertension effect, even this has just hinted that cell death also can bring into play effect.
As seen, probiotic bacteria all has sizable effect to treatment coronary heart disease and associated conditions thereof, should allow probiotic bacteria become the part of diet.
It is unbalance that disease comes from the interior flora of body.The intravital microorganism of people has more than the more than one hundred billion, and wherein the quantity of profitable strain (probiotic bacteria) and pernicious bacteria (virus) has been maintained the balance of the little ecology of human body.Along with low quality diet and environmental toxin are increasing, virus can surpass and destroy probiotic bacteria, will cause the unbalance of the interior microecosystem of body, so various diseases---cancer, coronary heart disease, obesity, unsociable and eccentric disease, diabetes, senile dementia etc. will come one after another.This product has solved the shortcoming that can only cure the symptoms, not the disease with chemical drugs and Chinese medicine, can fundamentally treat coronary heart disease and hypertension.
Product of the present invention adopts and stems from natural probiotic bacteria joint product, by adopting proper proportion and unique fermentation technology, good gas and anaerobies beneficial microbe Mixed culture through carefully screening, form diversified microbiologic population, the substrate (food) that benefit materials that these floras produce in growth and secretory substance thereof become separately or grow mutually, just by a kind of like this symbiosis propagation relation, formed complicated and stable microecosystem, formed the powerful and special advantages of diverse in function.
Compound probiotic makes thrombosis dissolve fast by clearing up the endovascular low density lipoprotein, LDL of human body (LDL) fast, is difficult to form with stylish thrombosis, thus the purpose that reaches treatment coronary heart disease and bring high blood pressure down.
Description of drawings
The invention will be further described below in conjunction with accompanying drawing.
Fig. 1 is a process chart of the present invention.
The specific embodiment
Compound probiotic of the present invention is to be made by the strain of following weight proportion:
The proportioning of bulgaricus bacillus, bacillus bifidus and Lactobacillus reuteri is respectively 1-5,1-4 and 3-7, and wherein their viable bacteria content is 18-26 hundred million/milliliter.
Compound probiotic of the present invention can also be to be made by the strain of following weight proportion:
The proportioning of bulgaricus bacillus, bacillus bifidus and Lactobacillus reuteri is respectively 2-4,1-3 and 4-6, and wherein their viable bacteria content is 20-24 hundred million/milliliter.
Referring to Fig. 1, the preparation method of compound probiotic of the present invention is as follows:
A, bulgaricus bacillus, bacillus bifidus and Lactobacillus reuteri are mixed according to described proportioning, putting into by Semen Maydis powder 6-14%, peptone 3-7%, glucose 6-14% and surplus is to cultivate in the culture medium of pure water;
B, above-mentioned strain was got final product at 20-24 ℃ of bottom fermentation 10-14 days in above-mentioned culture medium.
Preferably, the preparation method of compound probiotic of the present invention is as follows:
A, bulgaricus bacillus, bacillus bifidus and Lactobacillus reuteri are mixed according to described proportioning, putting into by Semen Maydis powder 8-12%, peptone 4-6%, glucose 8-12% and surplus is to cultivate in the culture medium of pure water;
B, above-mentioned strain was got final product at 20-24 ℃ of bottom fermentation 10-14 days in above-mentioned culture medium.
Embodiment 1:
Compound probiotic of the present invention is to be made by the strain of following weight proportion:
The proportioning of bulgaricus bacillus, bacillus bifidus and Lactobacillus reuteri is respectively 1,1 and 3, and wherein their viable bacteria content is 1,800,000,000/milliliter.
Embodiment 2:
Compound probiotic of the present invention is to be made by the strain of following weight proportion:
The proportioning of bulgaricus bacillus, bacillus bifidus and Lactobacillus reuteri is respectively 2,1 and 4, and wherein their viable bacteria content is 2,000,000,000/milliliter.
Embodiment 3:
Compound probiotic of the present invention is to be made by the strain of following weight proportion:
The proportioning of bulgaricus bacillus, bacillus bifidus and Lactobacillus reuteri is respectively 3,2 and 5, and wherein their viable bacteria content is 2,200,000,000/milliliter.
Embodiment 4:
Compound probiotic of the present invention is to be made by the strain of following weight proportion:
The proportioning of bulgaricus bacillus, bacillus bifidus and Lactobacillus reuteri is respectively 4,3 and 6, and wherein their viable bacteria content is 2,400,000,000/milliliter.
Embodiment 5:
Compound probiotic of the present invention is to be made by the strain of following weight proportion:
The proportioning of bulgaricus bacillus, bacillus bifidus and Lactobacillus reuteri is respectively 5,4 and 7, and wherein their viable bacteria content is 2,600,000,000/milliliter.
The preparation method of compound probiotic of the present invention is as follows:
A, bulgaricus bacillus, bacillus bifidus and Lactobacillus reuteri are mixed according to described proportioning, put into by Semen Maydis powder 6% or 8% or 10% or 12% or 14%, peptone 3% or 4% or 5% or 6% or 7%, glucose 6% 8% or 10% 12% or 14% and surplus be to cultivate in the culture medium of pure water;
B, with above-mentioned strain in above-mentioned culture medium at 20-24 ℃ of bottom fermentation 10 or got final product in 11 or 12 or 13 or 14 days.
Model case 1
Goldenrain tree so-and-so, woman, 88 years old, the Chaoyang District Beijing apartment for elderly people, the highest 170/100mmHg of hypertension took place in disease time: 2008.04.10 before 3 years, constipation throughout the year.Treatment history: once used multiple western medicine; Once medication and effect: captopril (100), three smart these Lepings, Hypotensor No 0 (Triamterene+Reserpine+Hydrochlorothiazide+Dihydralazine+Chlordiazepoxide) etc., antihypertensive effect is bad, still has discomfort.The main suit: nearly 3 years hypertensions, the aching and limp insomnia of frequent tired lower limb is vexed.
10 days to 2008 April in 2008, cut off all Western medicine on May 10,, quotes 50 milliliters of probiotic bacterias of the present invention every day after meal, and blood pressure is returned to normal condition, and every day Asiatic water closet pan once, spirit is refreshing strong.
Model case 2
Li Chun, man, 36 years old, the Dengshikou, disease time: more than 2 years, hypertension 160/100mmHg took place before 2 years, the treatment history: once used multiple western medicine, medication once and effect: FUFANG JIANGYA PIAN, Radix Salviae Miltiorrhizae Tabellae, effect is bad.Main suit: light headache and dizzy, insomnia.10 days to 2006 May in 2006, cut off all Western medicine on June 10,, quotes 50 milliliters of probiotic bacterias of the present invention every day after meal, and blood pressure is returned to normal condition, and sleep is good.
Model case 3
Lv Decao, man, 67 years old, the Zhongyuan District people of Zhengzhou City are in the work of Jinan, Shandong, and disease time: more than 10 years, the treatment history: once used multiple western medicine, medication once and effect: effect is bad.Symptom: coronary heart disease more than ten years. the severe heart infarction once showed effect one time, the heart that now constantly shows effect strand is painful, moving then nervous breathing hard. have a medical check-up: spirit is not good enough, lip. the slight cyanosis of complexion. blood pressure 146/90MMHG heart: border of cardiac dullness enlarges two horizontal fingers left, hear sounds blunt and a little less than, the 5th area of auscultation has blowing murmur. and surplus: still diagnosable: coronary heart disease is accompanied heart failure .2005 January 10 2006 November, cut off all Western medicine, quote 50 milliliters of probiotic bacterias of the present invention every day after meal, it is normal that health is recovered, and hear sounds and heart size all recover normal.
Clinical verification 10 examples, result such as following table
Claims (6)
1. compound probiotic for the treatment of hypertension and coronary heart disease, it is characterized in that described compound probiotic is to be made by the strain of following weight proportion: the proportioning of bulgaricus bacillus, bacillus bifidus and Lactobacillus reuteri is respectively 1-5,1-4 and 3-7, and wherein their viable bacteria content is 18-26 hundred million/milliliter; Its preparation method is: bulgaricus bacillus, bacillus bifidus and Lactobacillus reuteri are mixed according to described proportioning, and putting into by Semen Maydis powder 6-14%, peptone 3-7%, glucose 6-14% and surplus is to cultivate in the culture medium of pure water; Above-mentioned strain was got final product at 20-24 ℃ of bottom fermentation 10-14 days in above-mentioned culture medium.
2. according to the compound probiotic of described treatment hypertension of claim 1 and coronary heart disease, it is characterized in that described compound probiotic is to be made by the strain of following weight proportion: the proportioning of bulgaricus bacillus, bacillus bifidus and Lactobacillus reuteri is respectively 2-4,1-3 and 4-6, and wherein their viable bacteria content is 20-24 hundred million/milliliter.
3. according to the compound probiotic of described treatment hypertension of claim 2 and coronary heart disease, it is characterized in that described compound probiotic is to be made by the strain of following weight proportion: the proportioning of bulgaricus bacillus, bacillus bifidus and Lactobacillus reuteri is respectively 3,2 and 5, and wherein their viable bacteria content is 2,200,000,000/milliliter.
4. preparation method as the compound probiotic of treatment hypertension as described in claim 1 or 2 or 3 and coronary heart disease, this preparation method is as follows:
A, bulgaricus bacillus, bacillus bifidus and Lactobacillus reuteri are mixed according to described proportioning, putting into by Semen Maydis powder 6-14%, peptone 3-7%, glucose 6-14% and surplus is to cultivate in the culture medium of pure water;
B, above-mentioned strain was got final product at 20-24 ℃ of bottom fermentation 10-14 days in above-mentioned culture medium.
5. according to the preparation method of the compound probiotic of described treatment hypertension of claim 4 and coronary heart disease, this preparation method is as follows:
A, bulgaricus bacillus, bacillus bifidus and Lactobacillus reuteri are mixed according to described proportioning, putting into by Semen Maydis powder 8-12%, peptone 4-6%, glucose 8-12% and surplus is to cultivate in the culture medium of pure water;
B, above-mentioned strain was got final product at 20-24 ℃ of bottom fermentation 10-14 days in above-mentioned culture medium.
6. according to the preparation method of the compound probiotic of described treatment hypertension of claim 5 and coronary heart disease, this preparation method is as follows:
A, bulgaricus bacillus, bacillus bifidus and Lactobacillus reuteri are mixed according to described proportioning, putting into by Semen Maydis powder 10%, peptone 5%, glucose 10% and surplus is to cultivate in the culture medium of pure water;
B, above-mentioned strain was got final product at 20-24 ℃ of bottom fermentation in above-mentioned culture medium in 12 days.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100649980A CN101579361B (en) | 2009-05-18 | 2009-05-18 | Complex probiotics for curing hypertension and coronary heart disease and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100649980A CN101579361B (en) | 2009-05-18 | 2009-05-18 | Complex probiotics for curing hypertension and coronary heart disease and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101579361A CN101579361A (en) | 2009-11-18 |
| CN101579361B true CN101579361B (en) | 2011-08-24 |
Family
ID=41361766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009100649980A Active CN101579361B (en) | 2009-05-18 | 2009-05-18 | Complex probiotics for curing hypertension and coronary heart disease and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101579361B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201514303D0 (en) | 2015-07-16 | 2015-09-23 | Dupont Nutrition Biosci Aps | Bifidobacteria for treating cardiac conditions |
| CN105725185A (en) * | 2016-02-02 | 2016-07-06 | 武汉万德瑞生物技术有限公司 | Probiotic composition with blood pressure reduction function and preparing method and application thereof |
| JP6954995B2 (en) * | 2017-03-28 | 2021-10-27 | 森永乳業株式会社 | Composition for non-collagen glycoprotein degradation |
| CN112007051B (en) * | 2019-05-28 | 2022-05-10 | 景岳生物科技股份有限公司 | Composition for preventing apoplexy and improving apoplexy severity and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1628531A (en) * | 2003-12-17 | 2005-06-22 | 统一企业(中国)投资有限公司昆山研究开发中心 | Functionality sour milk containing Lactobacillus reuteri and making method thereof |
| WO2005060937A1 (en) * | 2003-12-23 | 2005-07-07 | Chr. Hansen A/S | Compressed tablets comprising viable probiotic microorganisms |
| CN101366734A (en) * | 2008-06-18 | 2009-02-18 | 辽宁大生药业有限公司 | Synbiotics medicament composition |
-
2009
- 2009-05-18 CN CN2009100649980A patent/CN101579361B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1628531A (en) * | 2003-12-17 | 2005-06-22 | 统一企业(中国)投资有限公司昆山研究开发中心 | Functionality sour milk containing Lactobacillus reuteri and making method thereof |
| WO2005060937A1 (en) * | 2003-12-23 | 2005-07-07 | Chr. Hansen A/S | Compressed tablets comprising viable probiotic microorganisms |
| CN101366734A (en) * | 2008-06-18 | 2009-02-18 | 辽宁大生药业有限公司 | Synbiotics medicament composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101579361A (en) | 2009-11-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI90086C (en) | FOERFARANDE FOER ISOLERING AV EN TERAPEUTISKT ANVAENDBAR LACTOBACILLUS ACIDOPHILUS -STAM | |
| DE60205646T2 (en) | COMPOSITION AND USES THEREOF COMPRISING A LACTOBACILLUS TRIBE | |
| CN108004189A (en) | A kind of compound probiotic lactic acid bacteria powder and preparation method and application | |
| CN101564133B (en) | Soybean yogurt and preparation method thereof | |
| CN110169983A (en) | A kind of compound probiotic lactic acid bacteria powder and application thereof for treating irritable bowel syndrome | |
| CN109123295A (en) | A kind of probiotics solid beverage and preparation method thereof | |
| JP2007518693A (en) | Stable liquid probiotic composition, its preparation and application | |
| JP2009507863A (en) | New use of white jellyfish miscellaneous polysaccharide or its extract | |
| RU2549709C1 (en) | Probiotic sour cream production method | |
| CN104430847B (en) | Lactobacillus fermenti Lactobacillus fermentum Lee working stock cultures products and its Constipation health purpose | |
| CN113249280B (en) | Streptococcus thermophilus STN26, bacterium powder and application in uric acid reducing product | |
| JP2023544655A (en) | Compositions that promote defecation and their uses | |
| CN102845695B (en) | Konjac fermented food and beverage and preparation method thereof | |
| CN101579361B (en) | Complex probiotics for curing hypertension and coronary heart disease and preparation method thereof | |
| CN104381440A (en) | Lactobacillus fermentum Lee working fermenting agent product and application thereof to prevent constipation and keep healthy | |
| AU2019245430A1 (en) | Compositions and methods for treating inflammatory bowel diseases | |
| CN115354002A (en) | Bacillus coagulans BC07, application thereof, bacteriostatic agent, medicine, food and bacteriostatic method | |
| CN117343857A (en) | Probiotic combination and application thereof in intestinal tract regulation, private care and mastitis prevention | |
| CN106954673A (en) | A kind of dairy products comprising probiotics and preparation method thereof | |
| JP2005269968A (en) | Lactic acid bacterium producing substance | |
| CN111419882B (en) | Bifidobacterium lactis for preventing and treating osteoporosis and application thereof | |
| CN106879739A (en) | A kind of microbial fermentation lactic acid formulation for containing four class viable bacterias and preparation method thereof | |
| CN109432333A (en) | A kind of synbiotic compound preparation and preparation method thereof for helping to alleviate no solid lesion hypertension symptom | |
| CN105385640A (en) | Lactococcus garviea and application thereof | |
| CN102754695A (en) | Burdock probiotics goat milk slices and method for preparing same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20151117 Address after: 310000 Zhejiang City, Binjiang District Province Long River Street, Autumn Road, No. 500, building 1, room 5, floor 501, room Patentee after: Hangzhou yuan Ding Biotechnology Co., Ltd. Address before: 473000, building 6, building 1, tobacco companies family hospital, Binhe East Road, Henan, Nanyang Province, 2 Patentee before: Xue Songxiao |
|
| C56 | Change in the name or address of the patentee | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 310000 Zhejiang City, Binjiang District Province Long River Street, Autumn Road, No. 500, building 1, room 5, floor 501, room Patentee after: Zhejiang Hong Wei Biotechnology Co., Ltd. Address before: 310000 Zhejiang City, Binjiang District Province Long River Street, Autumn Road, No. 500, building 1, room 5, floor 501, room Patentee before: Hangzhou yuan Ding Biotechnology Co., Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170426 Address after: Xigong road Dalian City, Liaoning province 116200 Pulandian City No. 800 Patentee after: Xue Songxiao Address before: 310000 Zhejiang City, Binjiang District Province Long River Street, Autumn Road, No. 500, building 1, room 5, floor 501, room Patentee before: Zhejiang Hong Wei Biotechnology Co., Ltd. |