CN101574391B - Prevention and treatment of diseases induced by microcirculation disturbance with compatible combination of total salvianolic acid and panax notoginoside - Google Patents
Prevention and treatment of diseases induced by microcirculation disturbance with compatible combination of total salvianolic acid and panax notoginoside Download PDFInfo
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- CN101574391B CN101574391B CN200810052995A CN200810052995A CN101574391B CN 101574391 B CN101574391 B CN 101574391B CN 200810052995 A CN200810052995 A CN 200810052995A CN 200810052995 A CN200810052995 A CN 200810052995A CN 101574391 B CN101574391 B CN 101574391B
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- Prior art keywords
- salviae miltiorrhizae
- application
- phenolic acids
- radix notoginseng
- radix salviae
- Prior art date
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Abstract
The invention relates to a new application of the compatibility of a traditional Chinese medicine total salvianolic acid and panax notoginoside, in particular to prevention and treatment of diseases induced by microcirculation disturbance with the compatible combination of total salvianolic acid and panax notoginoside.
Description
Technical field:
The present invention relates to the new purposes of the compatibility of tcm product Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins, particularly the compatibility of Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins is to the prevention and treatment of diseases effect of microcirculation disturbance initiation.
Background technology:
Radix Salviae Miltiorrhizae total phenolic acids (TSA) is the general name of phenolic acid compound in the red sage root water soluble ingredient.Radix Salviae Miltiorrhizae total phenolic acids can be applicable to prepare in the medicament of treatment cardiovascular and cerebrovascular disease, nephropathy, hepatopathy, pneumonia, pulmonary heart disease, pancreatitis, diabetes, cervical spondylosis, optical fundus blood vessel property disease, optical fundus nervous system disease, migraine, chronic gastritis, dizzy, Bone injury disease, high altitude disease, senile dementia etc.The method for preparing of Radix Salviae Miltiorrhizae total phenolic acids (TSA) has multiple; Be exemplified below: salvia piece or Radix Salviae Miltiorrhizae coarse powder elder generation's water or diluted alkaline in 30～99 ℃ carry at the beginning of down the water soluble ingredient in the Radix Salviae Miltiorrhizae; Extracting solution adds acid accent pH1～6 then; After deposition was removed impurity, convection drying or concentrated after drying got the extractum powder; Dry gained extractum powder is with 50～90% ethanol water reflux, extract, 1～4 time, and merge extractive liquid, leaves standstill, and gets supernatant, promptly gets high-purity Radix Salviae Miltiorrhizae total phenolic acids solution; Gained solution convection drying or concentrated after drying promptly get described Radix Salviae Miltiorrhizae total phenolic acids extractum powder.
Radix Notoginseng is the root of Araliaceae herbaceos perennial Radix Notoginseng Ranax notoginseng (Burk) F.H.Chen; Main product is in Yunnan, Guangxi and other places; Another name Radix Notoginseng, Radix Notoginseng. the main active of Radix Notoginseng is a Radix Notoginseng total arasaponins; It is about 12% to contain saponin in its tuber, isolates 20 kinds of dammarane type saponin from each position of Radix Notoginseng at present. and particularly the research of cardiovascular and cerebrovascular vessel pharmacology effect is very active to the pharmacological action of Radix Notoginseng total arasaponins both at home and abroad.Radix Notoginseng total arasaponins (PNS) has been listed NF in, and the corresponding preparations launch is arranged, as: panax notoginseng saponins for injection.Chinese patent CN200410058111.4 has described a kind of method for preparing of Radix Notoginseng total arasaponins: Radix Notoginseng is used water extraction, and extracting solution concentrates, ethanol precipitation; Supernatant eliminates ethanol, behind the water dissolution, and row macroporous resin HPD400 column chromatography; After water elution is removed impurity, reuse 90% ethanol elution, to the effective ingredient eluting fully till; Reclaim alcohol eluen, be drying to obtain.Specifically can adopt following method to obtain: to get pseudo-ginseng and be ground into coarse powder, add 70% ethanol of 10 times of medical material weight, reflux, extract, 2 times; Each 25 hours, filter, merge secondary raffinate; 70 ℃ of left and right sides decompression and solvent recoveries are the fluid extract of 1.10-1.12 to proportion.Dilute with water carries out the absorption of macroporous resin HPD400 adsorption column, uses water elution, continues with 90% ethanol elution 70 ℃ of left and right sides decompression and solvent recoveries of 90% ethanol elution part.In above-mentioned Radix Notoginseng total arasaponins solution, add MgO
2: AL
20
3Decolouring is filtered, and filtrates in 80 ℃ of reduced vacuum dryings, pulverizes, and promptly gets faint yellow Radix Notoginseng total arasaponins finished product.
Ischemical reperfusion injury is the main pathological basis that occurs damage behind interventional therapy, surgical operation, the thrombolytic.The main pathology link that leukocyte and vascular endothelial cell stick behind the ischemia-reperfusion, mast cell degranulation is blood vessel injury.
Microcirculation is the vascular bed that comprises arteriole, blood capillary, thin vein, accounts for 90% of the interior blood vessel of body, is to keep metabolic pith.Hyperlipemia, hypertension, infection, direct stimulation, traumatic injury, operation, interventional therapy etc. can cause microcirculation disturbance.Microcirculation disturbance comprises that blood vessel directly changes, peroxide generation, blood vessel endothelium adhesion factor ICAM-1, leukocyte adhesion factor CD11b/CD18 expression, leukocyte and vaso-active substance such as vascular endothelial cell adheres to, plasma albumin leaks outside, the outer mast cell degranulation of blood vessel discharges TNF-α, histamine, five hydroxytryptamine, inflammatory factor and form the complex process that blood is fastened, too many levels such as hemorrhage changes.
Mast cell degranulation is the main pathology link of an allergic reaction type, is pollinosis, dermatosis, asthma, diarrheal main pathological basis.
Whether the compatibility that it be not immediately clear Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins can improve the microcirculation disturbance that ischemia-reperfusion causes.The present invention has proved that the compatibility of Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins can improve the mesentery microcirculation disturbance that ischemia-reperfusion causes, thereby reaches the effect of the disease that treats and/or prevents the microcirculation disturbance initiation, and a kind of Chinese medicine pharmaceutical preparation is provided.
Summary of the invention:
The present invention relates to the new purposes of tcm product, particularly the prevention and the treatment improvement effect of the compatibility of Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins mesentery microcirculation disturbance that ischemia-reperfusion is caused.Thereby be applied to treat and/or prevent the disease that microcirculation disturbance causes, as: hyperlipemia, hypertension, infection, direct stimulation, traumatic injury, pollinosis, dermatosis, asthma, the microcirculation disturbance that diarrhoea, operation or interventional therapy etc. cause.
The present invention finds, 8: 2 compatibilities of TSA and PNS and 2: 8 compatibilities of TSA and PNS all can suppress leukocytic adhesion and mast cell degranulation.
Radix Salviae Miltiorrhizae total phenolic acids according to the invention, Radix Notoginseng total arasaponins can have been bought from market, also can meet medicinal standard and get final product according to prior art for preparing.
The medicine of preparation according to the invention is the pharmaceutical composition that the compatibility with above-mentioned Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins is prepared into as active constituents of medicine.
Pharmaceutical composition of the present invention comprises the pharmaceutical composition of the compatibility of Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins as active component, and Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins are with the weight proportion combination of 1-9: the 1-9 pharmaceutical composition as active component.Preferably Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins are with the weight proportion combination of 2: 8 and 8: 2 pharmaceutical composition as active component.
Pharmaceutical composition of the present invention; Can contain the medicine acceptable carrier as required; Wherein the compatibility of Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins is as active constituents of medicine, and its shared percentage by weight in compositions can be 0.1-99.9%, and all the other are the medicine acceptable carrier.Pharmaceutical composition of the present invention exists with unit dosage form, and said unit dosage form is meant the unit of preparation, as every of tablet, and capsular every capsules, every bottle of oral liquid, every bag of granule, every of injection etc.
Pharmaceutical composition of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.
Pharmaceutical composition of the present invention, the preparation of its oral administration can contain excipient commonly used, such as binding agent, filler, diluent, tablet agent, lubricant, disintegrating agent, coloring agent, flavoring agent and wetting agent, can carry out coating to tablet in case of necessity.
The filler that is suitable for comprises cellulose, mannitol, lactose and other similar filler.Suitable disintegrating agent comprises starch, polyvinylpyrrolidone and starch derivatives, for example sodium starch glycollate.Suitable lubricant comprises, for example magnesium stearate.The acceptable wetting agent of appropriate drug comprises sodium lauryl sulphate.
Can fill through mixing, the method that tabletting etc. are commonly used prepares solid oral composition.Mix repeatedly active substance is distributed in those compositionss of a large amount of filleies of whole use.
The form of oral liquid for example can be aqueous or oily suspensions, solution, Emulsion, syrup or elixir, perhaps can be a kind of available water before use or other suitable composite dry products of carrier.This liquid preparation can contain conventional additive; Such as suspending agent; For example sorbitol, syrup, methylcellulose, gelatin, hydroxyethyl-cellulose, carboxymethyl cellulose, aluminium stearate gel or hydrogenation edible fat; Emulsifying agent, for example lecithin, anhydro sorbitol monooleate or arabic gum; Non-aqueous carrier (they can comprise edible oil), for example almond oil, fractionated coconut oil, such as oily ester, propylene glycol or the ethanol of the ester of glycerol; Antiseptic, for example para hydroxybenzene methyl ester or propyl p-hydroxybenzoate or sorbic acid, and if desired, can contain conventional flavouring agent or coloring agent.
For injection, the liquid unit dosage forms of preparation contains active substance of the present invention and sterile carrier.According to carrier and concentration, can this chemical compound be suspended or dissolving.The preparation of solution is normally through being dissolved in active substance in a kind of carrier filter-sterilized before it is packed into a kind of suitable bottle or ampoule, sealing then.For example a kind of local anesthetic of adjuvant, antiseptic and buffer agent also can be dissolved in this carrier.In order to improve its stability, can be after the bottle of packing into that this compositions is freezing, and under vacuum, water is removed.
Pharmaceutical composition of the present invention; When being prepared into medicament, optionally add suitable medicine acceptable carrier; Said medicine acceptable carrier is selected from: mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, EDTA disodium, EDTA calcium sodium, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Pharmaceutical composition of the present invention is confirmed usage and dosage according to patient's situation in use, but obeys every day three times, each 1-20 agent, as: 1-20 bag or grain or sheet, every dose of 1mg-1000mg.
Therapeutic use of the present invention proves through following experiment:
Material and method
Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins provide by Tianjin Tasly Pharmaceutical Co., Ltd.
Laboratory animal
The Wister male rat of 200～250g is provided by Department Of Medicine, Peking University's animal center, and fasting 12 hours before the test can freely be drunk water, the animal quality certification number: SCXK (capital) 2002-0001.Animal is placed in conventional feeding environment, and the processing of animal handles according to the animal of Department Of Medicine, Peking University's regulation and the ethics policy is carried out.
The foundation of ischemia-reperfusion model and administration:
Ischemia-reperfusion group (I/R): press the consumption of 30mg/kg body weight, get sodium pentobarbital, execute lumbar injection and anaesthetize.Right external jugular vein rat is inserted No. 3 polyethylene intravenous tube, and keeps somewhere.Cut 20-30mm along the abdomen median line, softly nearly the ileum of ileocecus takes out outside the abdomen, is expanded on the observation platform of microscope slide.Krebs-Ringer buffer with 37 ℃ drips on unfolded mesentery continuously.The mesentery microcirculation dynamically with the handstand biological microscope (Diaphot TMD-2S, Nikon, Tokyo) that places 37 ℃ of calorstats, at 12V, is observed under the white light conditions of 100W.Under 20 times of composition lens, select look-out station,, observed content is preserved with the record of S-VHS video-tape with the free video recording system that shows.The look-out station of selecting is the microcirculatory vascular bed of diameter at the non-branch part of the thin vein between the 25-35um (length is more than 200 μ m).After observing through 10 minutes bases,, remove ligation again, will transfer to 0 place the time, observe dynamic 30 minutes of the microcirculation (1) of the same visual field continuously with the preceding mesentery arteriovenous of polyethylene tube ligation observation portion circulation 10 minutes.
Sham operated rats (Sham): rat anesthesia is opened abdomen, do not make ischemia-reperfusion and handle.
8: 2 preparatory administration groups of compatibility of Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins (Radix Salviae Miltiorrhizae total phenolic acids 8: Radix Notoginseng total arasaponins 2+I/R): ischemia before 20 minutes through jugular vein by the dosage of the 5mg/kg/h quiet Radix Salviae Miltiorrhizae total phenolic acids 8 that splashes into continuously: Radix Notoginseng total arasaponins 2 solution finish to observing.
2: 8 preparatory administration groups of compatibility of Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins (Radix Salviae Miltiorrhizae total phenolic acids 2: Radix Notoginseng total arasaponins 8+I/R): ischemia before 20 minutes through jugular vein by the dosage of the 5mg/kg/h quiet Radix Salviae Miltiorrhizae total phenolic acids 2 that splashes into continuously: Radix Notoginseng total arasaponins 8 solution finish to observing.
Every group of 6 rats.
Microcirculation is observed dynamically:
Microcirculation is dynamically with CCD camera system (CC-090, Flovel, Tokyo) that is connected in the handstand biological microscope and SIT fluorescent camera (C-2400-08, shore pine Off オ ト ニ Network ス, shore pine) record continuously.
The mensuration of blood vessel warp: survey blood vessel through time ground through (1,2) with video measuring gauge (IV-560, ホ ウ エ イ, Tokyo).
Adhere to the leukocyte count counting of thin vein tube wall: on the image of record, through the time ground counting stop the leukocyte (adhesion leukocyte) more than 30 seconds at the same position of thin vein tube wall, calculate adherent leukocyte count (1,2) on the long thin vein of 200 μ m.
Mast cell degranulation rate:, after 30 minutes 0.1%tolui dine blue is dripped at look-out station at ischemia-reperfusion, note down with ccd video camera.With 20 times to 5 visuals field of object lens countings take off granule and not degranulated mastocyte number, calculate the percentage ratio that degranulated mastocyte accounts for the whole mastocyte number of counting, be mast cell degranulation rate (1,2).
Statistical disposition:
Each measured value is handled with one-way analysis of variance (ANOVA), each group through the time change check with T, relatively check between each group with F.Each measured value representes that with the mean standard error P＜0.05 is a significance.
The result
1, the preparatory administration of the compatibility of Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins is to the influence of perfusion back rat mesentery arteriole and thin vein blood vessel warp again.
In this observing time, ischemia-reperfusion group rat arteriole and thin vein blood vessel directly do not have to take place significant the variation. and Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins are united preparatory administration (TSA8: PNS2 and TSA2: PNS8) all do not cause the significant change of pouring into back rat mesentery arteriole and thin vein blood vessel footpath again.
2, the preparatory administration of the compatibility of Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins is to pour into back rat leukocyte and the adherent inhibitory action of mesentery thin vein again.
As shown in Figure 1, the Sham group only has a spot of leukocyte adhesion in thin vein when this observation finishes.I/R group rat just has a large amount of leukocyte adhesions in the thin vein tube wall in early days in perfusion again, along with dabbling carrying out again, sticks leukocyte and increases gradually.The preparatory administration of the compatibility of Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins (TSA8: PNS2 and TSA2: PNS8) when perfusion begins again, just suppressed leukocytic adhesion significantly.
3, the preparatory administration of the compatibility of Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins is to the influence of matter mast cell degranulation between the rat mesentery of perfusion back again.
Fig. 2 shows that Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins unite preparatory administration to the influence of matter mast cell degranulation between the mesentery of perfusion back again.After pouring into 30 fens again, significantly increase with the mast cell degranulation rate of sham operated rats than, I/R group.The preparatory administration of the compatibility of Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins (TSA8: PNS2 and TSA2: PNS8) can suppress mast cell degranulation significantly.
Rat intestine cell membrane blood vessel does not directly have significant change behind the ischemia-reperfusion, and the leukocyte count and the mast cell degranulation rate in the blood vessel outer room matter tissue that stick on the thin vein tube wall significantly increase.8: 2 compatibility groups of TSA and PNS and 2: 8 compatibility groups of TSA and PNS all can suppress leukocytic adhesion and mast cell degranulation.
In a word, this research shows, the microcirculation disturbance that ischemia-reperfusion causes can prevented and treat to 8: 2 compatibility groups of Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins and 2: 8 compatibility groups of TSA and PNS.Thereby be applied to treat and/or prevent the disease that microcirculation disturbance causes; As: hyperlipemia, hypertension, infection etc. and because of direct stimulation, traumatic injury, pollinosis; Dermatosis, asthma, the microcirculation disturbance that diarrhoea, operation or interventional therapy etc. cause.
Description of drawings:
Fig. 1 representes that the Sham group only has a spot of leukocyte adhesion in thin vein when this observation finishes.
Fig. 2 representes that the preparatory administration of the compatibility of Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins is to the influence of matter mast cell degranulation between the mesentery of perfusion back again.
The specific embodiment:
Below further specify the present invention through embodiment, but not as limitation of the present invention.
Embodiment 1
Tablet
[prescription] Radix Notoginseng total arasaponins 90g Radix Salviae Miltiorrhizae total phenolic acids 10g calcium sulfate 150g
Microcrystalline Cellulose 50g micropowder silica gel 3g magnesium stearate 1.5g
[method for making] got former, adjuvant and crossed 100 mesh sieves respectively; Get Radix Notoginseng total arasaponins, Radix Salviae Miltiorrhizae total phenolic acids, calcium sulfate, microcrystalline Cellulose, mixing in right amount as binding agent system soft material, is crossed 20 mesh sieve system granules with 60% ethanol; 60 ℃ of dryings are taken out, and cross 30 mesh sieve granulate, add micropowder silica gel and magnesium stearate; Mixing, tabletting is processed 1000, promptly gets.
Embodiment 2
[prescription] Radix Notoginseng total arasaponins 80g Radix Salviae Miltiorrhizae total phenolic acids 20g calcium sulfate 112g
Microcrystalline Cellulose 37g micropowder silica gel 2.3g magnesium stearate 1.1g
[method for making] got former, adjuvant and crossed 100 mesh sieves respectively; Get Radix Notoginseng total arasaponins, Radix Salviae Miltiorrhizae total phenolic acids, calcium sulfate, microcrystalline Cellulose, mixing in right amount as binding agent system soft material, is crossed 20 mesh sieve system granules with 60% ethanol; 60 ℃ of dryings are taken out, and cross 30 mesh sieve granulate, add an amount of micropowder silica gel and magnesium stearate; Mixing, tabletting is processed 1000, promptly gets.
Embodiment 3
[prescription] Radix Salviae Miltiorrhizae total phenolic acids 20g Radix Notoginseng total arasaponins 80g calcium sulfate 200g
Microcrystalline Cellulose 66g micropowder silica gel 4g magnesium stearate 2g
[method for making] got former, adjuvant and crossed 100 mesh sieves respectively; Get Radix Salviae Miltiorrhizae total phenolic acids, Radix Notoginseng total arasaponins, calcium sulfate, microcrystalline Cellulose, mixing in right amount as binding agent system soft material, is crossed 20 mesh sieve system granules with 60% ethanol; 60 ℃ of dryings are taken out, and cross 30 mesh sieve granulate, add an amount of micropowder silica gel and magnesium stearate; Mixing, tabletting is processed 1000, promptly gets.
Embodiment 4
Capsule
Get Radix Salviae Miltiorrhizae total phenolic acids 90g Radix Notoginseng total arasaponins 10g, add appropriate amount of starch, adjuvants such as magnesium stearate are granulated, granulate, and the capsule of packing into No. 1 promptly gets.
Embodiment 5
Oral liquid
Get Radix Salviae Miltiorrhizae total phenolic acids 70g Radix Notoginseng total arasaponins 20g, add an amount of sucrose, antiseptic adds water to 1000ml, is distributed into one of 10ml, promptly gets oral liquid.
Embodiment 6
Granule
Get Radix Salviae Miltiorrhizae total phenolic acids 10g Radix Notoginseng total arasaponins 70g, add an amount of dextrin, steviosin, dry granulation, granulate, packing promptly gets.
Embodiment 7
Injection
Radix Salviae Miltiorrhizae total phenolic acids 30g Radix Notoginseng total arasaponins 75g is dissolved in water, and sodium chloride, ethylparaben add the hot water dissolving, mixing, adjust pH in addition.Water for injection is diluted to 1000ml, filters with hollow-fibre membrane, and fill, sterilization promptly gets.
Claims (10)
1. the application of the compositions of Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins in a kind of medicine that suppresses mast cell degranulation of preparation treatment.
2. the application of claim 1 is characterized in that, the compatibility of said Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins is Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins with weight ratio 2: 8-8: 2 mixed.
3. the application of claim 1 is characterized in that, said compositions is used for preparing the application of the microcirculation disturbance that the treatment mast cell degranulation causes.
4. the application of claim 1 is characterized in that, the compatibility of said Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins is that Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins are with 8: 2 mixed of weight ratio.
5. the application of claim 1 is characterized in that, the compatibility of said Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins is that Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins are with 2: 8 mixed of weight ratio.
6. the application of claim 1 is characterized in that, the weight compatibility ratio of Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins be 2: 8 preparatory administration to ischemia-reperfusion after between mesentery the matter mast cell degranulation inhibitory action is arranged.
7. the application of claim 1, said application is to pollinosis, dermatosis, asthma, the application of the microcirculation disturbance that diarrhoea causes.
8. the application of claim 1 is characterized in that, said pharmaceutical composition as active constituents of medicine, contains the medicine acceptable carrier with the compatibility of Radix Salviae Miltiorrhizae total phenolic acids and Radix Notoginseng total arasaponins simultaneously.
9. the application of claim 8 is characterized in that, said pharmaceutical composition is as any pharmaceutically useful dosage form.
10. the application of claim 9; It is characterized in that said dosage form is selected from: tablet, capsule, oral liquid, suck agent, granule, pill, powder, unguentum, sublimed preparation, suspensoid, solution, injection, suppository, cream, spray, drop or patch.
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| CN200810052995A CN101574391B (en) | 2008-05-05 | 2008-05-05 | Prevention and treatment of diseases induced by microcirculation disturbance with compatible combination of total salvianolic acid and panax notoginoside |
| PCT/CN2009/071632 WO2009135433A1 (en) | 2008-05-05 | 2009-05-04 | Use of total salvianolic acid, panax notoginsenosides and combination thereof in treating septicemia |
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| CN200810052995A CN101574391B (en) | 2008-05-05 | 2008-05-05 | Prevention and treatment of diseases induced by microcirculation disturbance with compatible combination of total salvianolic acid and panax notoginoside |
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| CN102048818A (en) * | 2009-11-05 | 2011-05-11 | 天津天士力制药股份有限公司 | Total salvianolic acid, panax notoginseng saponins, and compatibility thereof in prevention and treatment of diseases caused by microcirculatory disturbance |
| CN102100739B (en) * | 2009-12-17 | 2013-12-25 | 天士力制药集团股份有限公司 | Traditional Chinese medicine composition containing salvianic acid A and pseudoginseng root saponin R1 and application thereof |
| CN101912441A (en) * | 2010-08-18 | 2010-12-15 | 江西本草天工科技有限责任公司 | Effective part composite containing salvia miltiorrhiza bunge and panax pseudoginseng and preparation method and application thereof |
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| CN101006984B (en) * | 2007-02-01 | 2010-05-19 | 北京本草天源药物研究院 | An injection preparation containing salvianolic acid A and extract of panax natoginseng, and its preparation method and application |
| CN101327235B (en) * | 2007-06-21 | 2011-08-10 | 天津天士力制药股份有限公司 | Use of pseudo-ginseng saponins for treating septicemia |
| CN101327249B (en) * | 2007-06-21 | 2012-07-18 | 天津天士力制药股份有限公司 | Use of hydroxyphenyl lactic acid in preparing medicine for treating septicemia |
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Address after: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 city of the modern Chinese Medicine Applicant after: Tasly Pharmaceutical Group Co., Ltd. Address before: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 city of the modern Chinese Medicine Applicant before: Tianjin Tianshili Pharmaceutical Co., Ltd. |
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Address after: 300410 Tianjin city Beichen District Huaihe road and road intersection Dingjiang tianzhijiao Park forensic Center for Intellectual Property Department Patentee after: Tasly Pharmaceutical Group Limited by Share Ltd Address before: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 city of the modern Chinese Medicine Patentee before: Tasly Pharmaceutical Group Co., Ltd. |
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