CN101555232B - Pyridazinone compound marked by fluorine-18, preparation method and applications - Google Patents
Pyridazinone compound marked by fluorine-18, preparation method and applications Download PDFInfo
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- CN101555232B CN101555232B CN2009100845524A CN200910084552A CN101555232B CN 101555232 B CN101555232 B CN 101555232B CN 2009100845524 A CN2009100845524 A CN 2009100845524A CN 200910084552 A CN200910084552 A CN 200910084552A CN 101555232 B CN101555232 B CN 101555232B
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- pyridazinone
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- HYHVRDPIPYBIRC-UHFFFAOYSA-N CC(C)(C)N(C1=O)N=CC(O)=C1Cl Chemical compound CC(C)(C)N(C1=O)N=CC(O)=C1Cl HYHVRDPIPYBIRC-UHFFFAOYSA-N 0.000 description 2
- JOYJKVUVOBMZOP-UHFFFAOYSA-N CC(C)(C)N1N=CC(O)=C(C)C1=O Chemical compound CC(C)(C)N1N=CC(O)=C(C)C1=O JOYJKVUVOBMZOP-UHFFFAOYSA-N 0.000 description 1
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Application Number | Priority Date | Filing Date | Title |
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CN2009100845524A CN101555232B (en) | 2009-05-21 | 2009-05-21 | Pyridazinone compound marked by fluorine-18, preparation method and applications |
Applications Claiming Priority (1)
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CN2009100845524A CN101555232B (en) | 2009-05-21 | 2009-05-21 | Pyridazinone compound marked by fluorine-18, preparation method and applications |
Publications (2)
Publication Number | Publication Date |
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CN101555232A CN101555232A (en) | 2009-10-14 |
CN101555232B true CN101555232B (en) | 2011-01-05 |
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CN2009100845524A Expired - Fee Related CN101555232B (en) | 2009-05-21 | 2009-05-21 | Pyridazinone compound marked by fluorine-18, preparation method and applications |
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CN (1) | CN101555232B (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7344702B2 (en) | 2004-02-13 | 2008-03-18 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardial perfusion imaging |
US7485283B2 (en) | 2004-04-28 | 2009-02-03 | Lantheus Medical Imaging | Contrast agents for myocardial perfusion imaging |
AU2007339954B2 (en) | 2006-12-26 | 2013-06-20 | Lantheus Medical Imaging, Inc. | Ligands for imaging cardiac innervation |
CA2967254C (en) | 2008-02-29 | 2019-03-26 | Lantheus Medical Imaging, Inc. | Contrast agents for applications including imaging cancer |
DK2419096T3 (en) | 2009-04-15 | 2020-02-03 | Lantheus Medical Imaging Inc | STABILIZATION OF RADIOPHARMACEUTICAL COMPOSITIONS USING ASCORBIC ACID |
CN113058046A (en) | 2010-02-08 | 2021-07-02 | 兰休斯医疗成像公司 | Method and apparatus for synthesizing imaging agents and intermediates thereof |
BR122020018186B1 (en) | 2010-05-11 | 2021-07-27 | Lantheus Medical Imaging, Inc | USE OF IMAGING AGENTS TO PREPARE A COMPOSITION FOR DETECTION OF THE NOREPINEPHRIN CONVEYOR (NET) AND METHOD FOR THE DETECTION OF NET |
CN102336741B (en) * | 2011-07-06 | 2013-04-10 | 北京师范大学 | Fluorine-18-marked myocardial perfusion developing agent and preparation method and application thereof |
SG2014013767A (en) | 2011-09-09 | 2014-05-29 | Lantheus Medical Imaging Inc | Compositions, methods, and systems for the synthesis and use of imaging agents |
AU2013203000B9 (en) | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
CN102898421A (en) * | 2012-11-01 | 2013-01-30 | 张现忠 | Pyridazinone compound containing polyethyleneglycol (PEG) modified benzyl triazolyl and preparation method and application thereof |
WO2017038650A1 (en) * | 2015-08-28 | 2017-03-09 | 積水メディカル株式会社 | Benzyl compound |
CN107233585B (en) * | 2017-06-09 | 2021-01-22 | 四川大学华西医院 | Application of berberine or derivatives thereof in preparation of myocardial perfusion imaging agent |
CN111333638A (en) * | 2020-03-17 | 2020-06-26 | 四川大学华西医院 | 18F-labeled isoquinolino pyridazinone compound and synthesis method and application thereof |
CN111320620A (en) * | 2020-03-17 | 2020-06-23 | 四川大学华西医院 | Isoquinoline pyridazinone compound and synthesis method and application thereof |
CN112807276B (en) * | 2021-01-26 | 2022-03-01 | 北京先通国际医药科技股份有限公司 | Preparation method and application of pyridazinone myocardial perfusion PET radiopharmaceutical |
CN114835690B (en) * | 2022-07-04 | 2022-09-27 | 北京先通国际医药科技股份有限公司 | Preparation method of liquid composition containing compound I and application of liquid composition in myocardial perfusion PET imaging |
CN116425725A (en) * | 2022-07-26 | 2023-07-14 | 北京先通国际医药科技股份有限公司 | Preparation method and application of myocardial perfusion imaging agent precursor |
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2009
- 2009-05-21 CN CN2009100845524A patent/CN101555232B/en not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
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Ajay Purohit, et.al..Synthesis and Biological Evaluation of Pyridazinone Analogues as Potential Cardiac Positron Emission Tomography Tracers.《J. Med. Chem.》.2008,第51卷(第10期),2954-2970. * |
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Publication number | Publication date |
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CN101555232A (en) | 2009-10-14 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent for invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Zhang Xianzhong Inventor after: He Zuoxiang Inventor after: Mou Tiantian Inventor after: Yang Wenjiang Inventor after: Jing Huihui Inventor after: Lu Jie Inventor after: Tang Zhigang Inventor after: Zhang Junbo Inventor after: Wang Xuebin Inventor after: Fang Wei Inventor before: Zhang Xianzhong Inventor before: Mou Tiantian Inventor before: Yang Wenjiang Inventor before: Jing Huihui Inventor before: Lu Jie Inventor before: Tang Zhigang Inventor before: Zhang Junbo Inventor before: Wang Xuebin |
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COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: ZHANG XIANZHONG MOU TIANTIAN YANG WENJIANG JING HUIHUI LU JIE TANG ZHIGANG ZHANG JUNBO WANG XUEBIN TO: ZHANG XIANZHONG MOU TIANTIAN YANG WENJIANG JING HUIHUI LU JIE TANG ZHIGANG ZHANG JUNBO WANG XUEBIN FANG WEI HE ZUOXIANG |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110105 Termination date: 20170521 |