CN101549035A - Medicament for treating cerebral thrombosis and sequela diseases and preparation method thereof - Google Patents
Medicament for treating cerebral thrombosis and sequela diseases and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese traditional compound medicine preparation for treating cerebral thrombosis and sequela diseases and a preparation method thereof. The Chinese traditional compound medicine preparation is prepared by the bulk drugs with the following weight portions: 80 to 200 portions of Salvia miltiorrhiza, 100 to 220 portions of red paeonia, 60 to 180 portions of Gardenia, 100 to 180 portions of Astragalus root, as well as 80 to 100 portions of peach kernel. Pharmacological test and clinical trial show that the Chinese traditional compound medicine preparation has the effect of improving cerebral blood circulation, can effectively prevent and control cerebral thrombosis and sequela diseases, and is convenient to be eaten, is easy to be absorbed, and does not have side effects. Meanwhile, the preparation method for the Chinese traditional compound medicine preparation has simple and stable technique, is high in contents of extracted effective components and maneuverability, and is suitable for industrial production.
Description
Technical field
The present invention relates to a kind of medicine, specifically relate to a kind of Chinese traditional compound medicine and preparation method thereof and be used for preparing the application of treatment cerebral thrombosis and sequela diseases medicine thereof with it.
Background technology
The old people is the main morbidity colony of cardiovascular and cerebrovascular disease, show according to statistics, 2004, China more than 60 years old population reach more than 300,000,000, arriving along with aged tendency of population, make the population of this age bracket that very big growth arranged, cardiovascular and cerebrovascular disease patient group is also corresponding to increase, meanwhile, modern society is from work, society, the pressure of aspects such as life, add that life is irregular, diet is science and do not get enough athletic exercise etc. not, impels the sickness rate of cardiovascular and cerebrovascular disease in 30 years old to 40 years old young and middle-aged people also constantly to rise, and the highest disease of China resident mortality rate is a cardiovascular and cerebrovascular disease.
At present, the drug main for the treatment of cardiovascular and cerebrovascular disease clinically will be based on chemicals, but chemicals is taken for a long time, a lot of untoward reaction occurred, the patient takes for a long time and has produced Drug resistance, the curative effect variation, and chemicals costs an arm and a leg, and can not excellent popularization use.
Summary of the invention
Goal of the invention: the objective of the invention is to solve the deficiencies in the prior art, a kind of Chinese traditional compound medicine and preparation method thereof is provided, a further object of the invention is the application that is used to prepare treatment cerebral thrombosis and sequela diseases medicine thereof.
Technical scheme: in order to realize above purpose, Chinese traditional compound medicine provided by the invention is made by the crude drug of following weight fraction: Radix Salviae Miltiorrhizae 80-200 part, Radix Paeoniae Rubra 100-220 part, Fructus Gardeniae 60-180 part, Radix Astragali 100-180 part, Semen Persicae 80-100 part.
As preferred version, Chinese traditional compound medicine provided by the invention is to be made by the crude drug of following parts by weight: 180 parts of Radix Salviae Miltiorrhizaes, 180 parts of Radix Paeoniae Rubra, 130 parts of Fructus Gardeniaes, 150 parts of the Radixs Astragali, 100 parts in Semen Persicae.
As another preferred version, Chinese traditional compound medicine provided by the invention is to be made by the crude drug of following parts by weight: 175 parts of Radix Salviae Miltiorrhizaes, 175 parts of Radix Paeoniae Rubra, 130 parts of Fructus Gardeniaes, 122 parts of the Radixs Astragali, 122 parts in Semen Persicae.
Chinese traditional compound medicine provided by the invention can become oral liquid, granule, capsule, tablet, injectable powder or injection drug form with each extracts of bulk drugs with pharmaceutically acceptable preparing carriers.
When the extract of each raw material of Chinese traditional compound medicine provided by the invention is made oral liquid, the extract of each raw material is added the purified water dissolving, add syrup, regulate pH, make oral liquid.
When the extract of each raw material of Chinese traditional compound medicine provided by the invention is made tablet, the extract of each raw material and lactose or corn starch, add magnesium stearate lubricant when needing, mix homogeneously is granulated, and tabletting is made tablet then.
When making capsule, the extract of each raw material of Chinese traditional compound medicine provided by the invention, granulates the encapsulated then capsule of making the extract of each raw material and carrier lactose or corn starch mix homogeneously.
When the extract of each raw material of Chinese traditional compound medicine provided by the invention is made granule, the extract of each raw material and diluent lactose or corn starch mix homogeneously, granulate, drying is made granule.
When the extract of each raw material of Chinese traditional compound medicine provided by the invention was made injectable powder, the extract lyophilization of each raw material, injectable powder was made in sterilization.
When the extract of each raw material of Chinese traditional compound medicine provided by the invention is made injection, the extract of getting each raw material adds physiological saline solution and adds activated carbon then, stir, 80 ℃ were heated 30 minutes, filter, regulate pH value, be filtered to clear and bright with sintered glass funnel or other filter, fill was made injection in 30 minutes 100 to 115 ℃ of sterilizations.
The preparation method of Chinese traditional compound medicine provided by the invention may further comprise the steps:
(1) gets Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Fructus Gardeniae, the Radix Astragali and Semen Persicae and mix, decoct with water, merge fried liquid;
(2) get step (1) gained medicinal liquid and concentrate, under constantly stirring, adding ethanol, stir, cold preservation, filtration, filtrate;
(3) get step (2) gained filtrate recycling ethanol, add water after concentrating, cold preservation filters, and gets filtrate;
(4) get step (3) gained filtrate, regulate pH value, concentrate, add pharmaceutically acceptable carrier and make preparation.
The preparation method of Chinese traditional compound medicine provided by the invention, wherein amount of water is 4～8 times of medical material amount in the step (1), decocting number of times is 2-4 time, 1-2 hour at every turn.
The preparation method of Chinese traditional compound medicine provided by the invention: the relative density after wherein decoction liquor concentrates in the step (2) is 1.1～1.2, concentration of ethanol reaches 70-90% in the medicinal liquid in order to make to concentrate back adding amount of alcohol, refrigerated storage temperature is 0～4 ℃, and cold preservation time is 48～96 hours.
The preparation method of Chinese traditional compound medicine provided by the invention: wherein the relative density of medicinal liquid is 1.0～1.1 behind the middle recovery of step (3) ethanol, and concentrated back amount of water is 6～10 times of medicinal liquid, and refrigerated storage temperature is 0～4 ℃, and cold preservation time is 48～96 hours.
The preparation method of Chinese traditional compound medicine provided by the invention: wherein the scope of step (4) adjusting pH value is 6.8～7.3, and the relative density that concentrates the back medicinal liquid is 1.1～1.2.
The application of Chinese traditional compound medicine provided by the invention in preparation treatment cerebral thrombosis and sequela diseases medicine thereof.
Chinese traditional compound medicine provided by the invention is made the application in preparation treatment cerebral thrombosis and sequela diseases medicine thereof of oral liquid, tablet, capsule, granule, injectable powder or injection drug form.
Beneficial effect: the present invention is according to Chinese medical theory, and determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs is formulated the present invention through scientific composition, test shows that this medical instrument has the good control cerebral thrombosis and the effect of sequela, and taking convenience is easy to absorb, and has no side effect, five kinds of Chinese crude drug raw materials that the present invention relates to are conventional Chinese medicine, crude drug is easy to get, the preparation method of while Chinese traditional compound medicine provided by the invention, and technology is simple, stable, effective component extracting content height, workable, be fit to industrialized great production.
The specific embodiment:
Further illustrate the present invention below in conjunction with specific embodiment, should understand these embodiment only is used to the present invention is described and is not used in and limit the scope of the invention, after having read the present invention, those skilled in the art all fall within the application's claims institute restricted portion to the modification of the various equivalent form of values of the present invention.
Embodiment 1:
The crude drug of Chinese traditional compound medicine is formed: Radix Salviae Miltiorrhizae 175g, Radix Paeoniae Rubra 175g, Fructus Gardeniae 130g, Radix Astragali 122g, Semen Persicae 122g.
Preparation method: ginseng 175g, Radix Paeoniae Rubra 175g, Fructus Gardeniae 130g, Radix Astragali 122g, Semen Persicae 122g decocts with water 3 times, the purified water that adds for the first time 7 times of amounts, decocted 1.5 hours, and added the purified water of 6 times of amounts for the second time, decocted 1 hour, the purified water that adds 5 times of amounts for the third time, decocted 1 hour, and merged three times fried liquid, concentrated medicament is to relative density 1.1, under constantly stirring, slowly add ethanol make in the medicinal liquid concentration of alcohol reach 75% (table is surveyed, 20 ℃), after stirring, with medicinal liquid in 0 ℃ of cold preservation 72 hours, filter with the titanium filter stick then, filtrate recycling ethanol, concentrated medicament are to relative density 1.0, and concentrated solution adds the purified water of 8 times of amounts under constantly stirring, medicinal liquid is in 0 ℃ of cold preservation more than 90 hours, the reuse plate-and-frame filtration is regulated pH value to 7.0, and filtrate is concentrated into relative density 1.1, add syrup, regulate pH to 7.5, promptly get oral liquid 1000ml, embedding, sterilization, promptly.(lot number: 001)
Embodiment 2:
The crude drug of Chinese traditional compound medicine is formed: Radix Salviae Miltiorrhizae 180, Radix Paeoniae Rubra 180, Fructus Gardeniae 130, the Radix Astragali 150, Semen Persicae 100.
Preparation method: get Radix Salviae Miltiorrhizae 180, Radix Paeoniae Rubra 180, Fructus Gardeniae 130, the Radix Astragali 150, Semen Persicae 100 decocts with water three times, the purified water that adds for the first time 8 times of amounts, decocted 2 hours, the purified water that adds for the second time 6 times of amounts, decocted 1 hour, and added the purified water of 5 times of amounts for the third time, decocted 1 hour, merge three times fried liquid, concentrated medicament is to relative density 1.2, slowly adds ethanol and make that concentration of alcohol reaches 80% (table is surveyed, 20 ℃) in the medicinal liquid under constantly stirring, after stirring, medicinal liquid filters filtrate recycling ethanol then in 4 ℃ of cold preservations 96 hours with the titanium filter stick, concentrated medicament is to relative density 1.1, concentrated solution adds the purified water of 10 times of amounts under constantly stirring, medicinal liquid is in 4 ℃ of cold preservations 96 hours, reuse plate-and-frame filtration, regulate pH value to 7.3, filtrate is concentrated into relative density 1.2, and spray drying gets the solids extraction thing, adds an amount of Icing Sugar and stabilizing agent, granule is made in granulation or tabletting is made tablet.(lot number 002)
Embodiment 3:
The crude drug of Chinese traditional compound medicine is formed: Radix Salviae Miltiorrhizae 200g, Radix Paeoniae Rubra 200g, Fructus Gardeniae 150g, Radix Astragali 120g, Semen Persicae 100g.
Preparation method: get Radix Salviae Miltiorrhizae 200g, Radix Paeoniae Rubra 200g, Fructus Gardeniae 150g, Radix Astragali 120g, Semen Persicae 100g decocts with water three times, the purified water that adds for the first time 7 times of amounts, decocted 2 hours, the purified water that adds for the second time 6 times of amounts, decocted 1 hour, and added the purified water of 4 times of amounts for the third time, decocted 1 hour, merge three times fried liquid, concentrated medicament is to relative density 1.1, slowly adds ethanol and make that concentration of alcohol reaches 80% (table is surveyed, 20 ℃) in the medicinal liquid under constantly stirring, after stirring, medicinal liquid filters filtrate recycling ethanol then in 2 ℃ of cold preservations 48 hours with the titanium filter stick, concentrated medicament is to relative density 1.0, concentrated solution adds the purified water of 6 times of amounts under constantly stirring, medicinal liquid is in 1 ℃ of cold preservation 48 hours, reuse plate-and-frame filtration, regulate pH value to 6.8, filtrate is concentrated into relative density 1.1, and spray drying gets the solids extraction thing, adds appropriate amount of starch or cyclodextrin, granulate the encapsulated capsule of making.(lot number 003)
Embodiment 4:
The crude drug of Chinese traditional compound medicine is formed: Radix Salviae Miltiorrhizae 80g, Radix Paeoniae Rubra 100g, Fructus Gardeniae 60g, Radix Astragali 100g, Semen Persicae 80g.
Preparation method: get Radix Salviae Miltiorrhizae 80g, Radix Paeoniae Rubra 100g, Fructus Gardeniae 60g, Radix Astragali 100g, Semen Persicae 80g decocts with water three times, the purified water that adds for the first time 8 times of amounts, decocted 1.5 hours, and added the purified water of 6 times of amounts for the second time, decocted 1 hour, the purified water that adds 5 times of amounts for the third time, decocted 1 hour, and merged three times fried liquid, concentrated medicament is to relative density 1.2, under constantly stirring, slowly add ethanol make in the medicinal liquid concentration of alcohol reach 70% (table is surveyed, 20 ℃), after stirring, medicinal liquid was in 0 ℃ of cold preservation 72 hours, filter with the titanium filter stick then, filtrate recycling ethanol, concentrated medicament to relative density is 1.0, concentrated solution adds the purified water of 10 times of amounts under constantly stirring, medicinal liquid was in 4 ℃ of cold preservations 96 hours, the reuse plate-and-frame filtration is regulated pH value to 7.0, and filtrate is concentrated into relative density 1.1, be spray dried to Powdered, make injectable powder or add glucose or chloride injection water,, filter through the active carbon roguing, and in 105 ℃ of heat sterilizations 30 minutes, injection was made in fill.(lot number 004)
Embodiment 5:
The crude drug of Chinese traditional compound medicine is formed: Radix Salviae Miltiorrhizae 200g, Radix Paeoniae Rubra 220g, Fructus Gardeniae 180g, Radix Astragali 180g, Semen Persicae 100g.
Preparation method: get Radix Salviae Miltiorrhizae 200g, Radix Paeoniae Rubra 220g, Fructus Gardeniae 180g, Radix Astragali 180g, Semen Persicae 100g decocts with water three times, the purified water that adds for the first time 8 times of amounts, decocted 2 hours, and added the purified water of 6 times of amounts for the second time, decocted 1 hour, the purified water that adds 4 times of amounts for the third time, decocted 1 hour, and merged three times fried liquid, concentrated medicament is to relative density 1.1, under constantly stirring, slowly add ethanol make in the medicinal liquid concentration of alcohol reach 80% (table is surveyed, 20 ℃), after stirring, medicinal liquid was in 0 ℃ of cold preservation 72 hours, filter with the titanium filter stick then, filtrate recycling ethanol, concentrated medicament to relative density is 1.0, concentrated solution adds the purified water of 8 times of amounts under constantly stirring, medicinal liquid was in 0 ℃ of cold preservation 96 hours, the reuse plate-and-frame filtration is regulated pH value to 7.1, and filtrate is concentrated into relative density 1.2, be spray dried to Powdered, make injectable powder or add glucose or chloride injection water,, filter through the active carbon roguing, and in 105 ℃ of heat sterilizations 30 minutes, injection was made in fill.(lot number 005)
Embodiment 6: pharmacological evaluation
1, experiment material
1.1 medicine and reagent
(1) Chinese traditional compound medicine provided by the invention (lot number 001) faces with preceding and is made into desired concn with normal saline;
(2) heparin sodium injection, the biological thousand red pharmaceutical Co. Ltds in Changzhou, lot number: 071217;
(3) Buddhist nun's film Horizon, German Bayer AG produces, lot number: BXNWUW1-1;
(4) pentobarbital sodium, Beijing chemical reagents corporation (German import packing), lot number: 080402;
1.2 experimental apparatus
(1) RM-6000 eight road physiology monitor and adnexaes thereof, Japanese NIHON KOHDEN company
(2) OM.MFV3100/3200 electromagnetic flowmeter, Japanese NIHON KOHDEN company
2, laboratory animal
The hybrid dog, body weight 7-10kg, the male and female dual-purpose provides by animal cultivation field, Green Dragon mountain, Nanjing, after quarantine and 2 weeks of anthelmintic, is used for this experiment.
3, statistical procedures
Data represent that with mean ± standard deviation (X ± S), all data adopt the Student-t check.
Before rate of change %=(after the X administration-X administration before)/X administration * 100%
Be the observation after the administration after the X administration, be the observation before the administration before the X administration.
4, experimental technique and grouping
30 of domesticated dogs, body weight is 7～10Kg, the male and female dual-purpose, be divided into 5 groups: blank group (giving the isometric(al) normal saline), nimodipine group (0.04mg/kg), medicine low dose group of the present invention (50mg/kg), middle dosage group (100mg/kg), high dose group (200mg/kg), each organizes the administration volume is 1ml/kg.
Get domesticated dog, body weight is 7～10Kg, the male and female dual-purpose.With the subcutaneous cephalic vein anesthesia of 3% pentobarbital sodium 30mg/kg forelimb, back of the body position is fixed on the operating-table, cuts off the hair of cervical region and left hind inboard.Separate femoral vein and insert venous cannulation, slowly constant speed input normal saline (about 1ml/min); Separate femoral artery and insert arterial cannulation (being full of the heparin-saline of 500u/ml in the pipe), to measure arteriotony.Separate internal carotid artery and vertebra aorta: along cervical region median line otch, isolate right common carotid artery along the trachea right part, mention common carotid artery and slightly outwards traction with cordonnet, separate to the sternocleidomastoid direction along common carotid artery, go out the transverse process of cervical region under with finger touch, to lower limb direction 1.5cm one depression is arranged at this outstanding 1cm to the midline, can touch the tangible tremulous pulse of beating and be vertebral artery, separate with connective tissue on every side with little curved hemostat vertebral artery, with the left-hand finger is guiding, picks up vertebral artery gently with long mosquito forceps, and threading, place the electromagnetic blood flowmeter probe (1.5mm) of suitable internal diameter, measure vertebral artery blood flow (VAF); Isolate external carotid artery before the lower jaw deep enters intracranial along the common carotid artery head-end, and with ligation, at this moment place the electromagnetic blood flowmeter probe (2mm) of suitable internal diameter, record the common carotid artery blood flow and be ICAF amount (ICBF) this moment.When experiment finishes, put to death animal, open cranium and take out full brain and weigh, with full brain weight divided by 2 a side brain is heavy.Calculate cerebral blood flow (ICF) and cerebral vascular resistance (ICR) by following formula, and t method of inspection and normal saline group are carried out the statistics comparison between the employing group.
5, experimental result
Specifically experimental result is as shown in Table 1 and Table 2:
Table 1 Chinese traditional compound medicine provided by the invention is to influence (X ± S) (n=5) of anesthetized dog cerebral vascular resistance (ICR)
Compare with the normal saline group
*P＜0.05,
*P＜0.01
Table 2 Chinese traditional compound medicine provided by the invention is to influence (X ± S) (n=5) of anesthetized dog cerebral blood flow (ICF)
Compare with the normal saline group
*P＜0.05,
*P＜0.01
Show that by experimental result the vertebral artery and the ICAF amount that award anesthetized dog behind the Chinese traditional compound medicine provided by the invention increase, the dog cerebral vascular resistance reduces, illustrated that Chinese traditional compound medicine provided by the invention can reduce mean arterial pressure, cerebral blood flow increasing, reduce cerebral vascular resistance, have the effect that improves the anesthetized dog cerebral circulation.
Embodiment 7 clinical trials
Choose 47 routine cerebral thrombosis patients, be divided into A, B at random and organize wherein that A organizes 25 examples, male 18 examples, women 7 examples; B organizes 22 examples, wherein male 17 examples, and women 5 examples are tried patient age all at 45～70 years old, all meet the standard that nineteen ninety-five whole nation cerebrovascular disease academic conference is formulated, and each is organized clinical basic document and has comparability.
Detect before two groups of cerebral thrombosis patients of A, B test and show the symptoms of intracranial hypertension that all exists in various degree.A group patient takes Chinese traditional compound medicine of the present invention, and 4～6 weeks were 1 course of treatment, and B group patient takes FUFANG DANSHEN PIAN, and 4 weeks were 1 course of treatment.Result of the test shows that the total effective rate of Chinese traditional compound medicine of the present invention and compound Salviae Miltiorrhizae is respectively 92% and 73%, and the result shows that the curative effect of Chinese traditional compound medicine provided by the invention is better than FUFANG DANSHEN PIAN, and significant difference.
Test shows that Chinese traditional compound medicine provided by the present invention has the effect of good curing cerebral thrombosis, and does not have obvious adverse reaction, and being expected to develop becomes a new generation's treatment cerebral thrombosis and move the medicine of disease thereafter.
Claims (10)
1, a kind of Chinese traditional compound medicine is characterized in that, it is made by the crude drug of following parts by weight: Radix Salviae Miltiorrhizae 80-200 part, Radix Paeoniae Rubra 100-220 part, Fructus Gardeniae 60-180 part, Radix Astragali 100-180 part, Semen Persicae 80-100 part.
2, Chinese traditional compound medicine according to claim 1 is characterized in that, it is made by the crude drug of following parts by weight: 180 parts of Radix Salviae Miltiorrhizaes, 180 parts of Radix Paeoniae Rubra, 130 parts of Fructus Gardeniaes, 150 parts of the Radixs Astragali, 100 parts in Semen Persicae.
3, Chinese traditional compound medicine according to claim 1 is characterized in that, it is made by the crude drug of following parts by weight: 175 parts of Radix Salviae Miltiorrhizaes, 175 parts of Radix Paeoniae Rubra, 130 parts of Fructus Gardeniaes, 122 parts of the Radixs Astragali, 122 parts in Semen Persicae.
4, Chinese traditional compound medicine according to claim 1 is characterized in that, each extracts of bulk drugs is become the medicine of oral liquid, granule, capsule, tablet, injectable powder or injection dosage form with pharmaceutically acceptable preparing carriers.
5, the preparation method of the described Chinese traditional compound medicine of claim 1 is characterized in that may further comprise the steps:
(1) gets Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Fructus Gardeniae, the Radix Astragali and Semen Persicae and mix, decoct with water, merge fried liquid;
(2) get step (1) gained medicinal liquid and concentrate, under constantly stirring, adding ethanol, stir, cold preservation, filtration, filtrate;
(3) get step (2) gained filtrate recycling ethanol, add water after concentrating, cold preservation filters, and gets filtrate;
(4) get step (3) gained filtrate, regulate pH value, concentrate, add pharmaceutically acceptable carrier and make preparation.
6, the preparation method of Chinese traditional compound medicine according to claim 5 is characterized in that: the middle amount of water of step (1) is 4～8 times of medical material amount, and decocting number of times is 2-4 time, each 1-2 hour.
7, the preparation method of Chinese traditional compound medicine according to claim 5, it is characterized in that: the relative density after decoction liquor concentrates in the step (2) is 1.1～1.2, concentration of ethanol reaches 70-90% in the medicinal liquid in order to make to concentrate back adding amount of alcohol, refrigerated storage temperature is 0～4 ℃, and cold preservation time is 48～96 hours.
8, the preparation method of Chinese traditional compound medicine according to claim 5, it is characterized in that: the relative density of medicinal liquid is 1.0～1.1 behind the middle recovery of step (3) ethanol, concentrated back amount of water is 6～10 times of medicinal liquid, and refrigerated storage temperature is 0～4 ℃, and cold preservation time is 48～96 hours.
9, the preparation method of Chinese traditional compound medicine according to claim 5 is characterized in that: the scope that step (4) is regulated pH value is 6.8～7.3, and the relative density that concentrates the back medicinal liquid is 1.1～1.2.
10, the application of each described Chinese traditional compound medicine of claim 1 to 4 in preparation treatment cerebral thrombosis and sequela diseases medicine.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105477113A (en) * | 2016-01-12 | 2016-04-13 | 魏秀芝 | Pharmaceutical composition for treating cerebral stroke |
| CN105663289A (en) * | 2016-03-30 | 2016-06-15 | 沈阳浑河新城中西医结合医院 | Compound anti-thrombus traditional Chinese medicine preparation composition |
| CN105663573A (en) * | 2016-01-08 | 2016-06-15 | 青岛市市立医院 | Medicinal liquid for promoting fracture healing |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101172141A (en) * | 2005-05-24 | 2008-05-07 | 马希文 | Drug for curing coronary disease |
| CN101244206B (en) * | 2007-02-16 | 2011-07-20 | 刘振宏 | Pharmaceutical combination for treating cerebral thrombus and preparation thereof |
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2009
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105663573A (en) * | 2016-01-08 | 2016-06-15 | 青岛市市立医院 | Medicinal liquid for promoting fracture healing |
| CN105477113A (en) * | 2016-01-12 | 2016-04-13 | 魏秀芝 | Pharmaceutical composition for treating cerebral stroke |
| CN105663289A (en) * | 2016-03-30 | 2016-06-15 | 沈阳浑河新城中西医结合医院 | Compound anti-thrombus traditional Chinese medicine preparation composition |
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