CN101525464A - Novel material for totally nontoxic non-polyvinyl chloride medical perfusion tube and method for manufacturing same - Google Patents
Novel material for totally nontoxic non-polyvinyl chloride medical perfusion tube and method for manufacturing same Download PDFInfo
- Publication number
- CN101525464A CN101525464A CN200910096680A CN200910096680A CN101525464A CN 101525464 A CN101525464 A CN 101525464A CN 200910096680 A CN200910096680 A CN 200910096680A CN 200910096680 A CN200910096680 A CN 200910096680A CN 101525464 A CN101525464 A CN 101525464A
- Authority
- CN
- China
- Prior art keywords
- perfusion tube
- polyvinyl chloride
- medical perfusion
- block copolymer
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/92—Measuring, controlling or regulating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C2948/00—Indexing scheme relating to extrusion moulding
- B29C2948/92—Measuring, controlling or regulating
- B29C2948/92504—Controlled parameter
- B29C2948/92704—Temperature
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C2948/00—Indexing scheme relating to extrusion moulding
- B29C2948/92—Measuring, controlling or regulating
- B29C2948/92819—Location or phase of control
- B29C2948/92857—Extrusion unit
- B29C2948/92876—Feeding, melting, plasticising or pumping zones, e.g. the melt itself
- B29C2948/92895—Barrel or housing
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention provides a novel material for a totally nontoxic non-polyvinyl chloride medical perfusion tube. The novel material is characterized in that the material contains the following materials according to the weight percentages thereof: 100 parts of styrene-hydrogenation dialkene block copolymer which is partially hydrogenated, 5-200 parts of ethylene-propylene copolymer of low molecular weight, and 0.01-10 parts of modified natural oxidation inhibitor vitamin E. The invention further provides a method for manufacturing the novel material. A medical perfusion tube made of the novel material has the advantages of high transparency, high flexibility, steam and dry-heat resistance superior to the PVC medical perfusion tube, and better than the PVC medical perfusion tube in terms of mechanical performance. The medical perfusion tube made of the novel material is totally nontoxic, can not generate allergy, variation and exclusive reaction to human organizations, has the high temperature resistance, aging resistance and uvioresistant performance, can be directly sterilized through high temperature boiling and ultraviolet rays. The novel material of the medical perfusion tube can completely replace PVC and be used for producing medical perfusion tubes of various specifications.
Description
Technical field
The present invention relates to a kind of non-polyvinyl chloride medical perfusion tube type material and manufacture method thereof of totally nontoxic, belong to the polymkeric substance field of medical materials.
Background technology
Polyvinyl chloride (PVC) tubing has not cracky, the transparency is high, does not twist together when normally using, advantage such as high temperature-resistant disinfected and good mechanical property.For a long time, at home and abroad medical infusion lines all is to adopt polyvinyl chloride to produce.But because the PVC material is harder, makes tubing and must add softening agent, as phthalic acid two (2-ethylhexyl) ester (DEHP), epoxy soybean wet goods, the former is the most commonly used.In infusion process, the DEHP of PVC tubing can disengage to transfusion, and the particulate matter in the solution is obviously increased; Also may interact, influence drug quality with medicine.At present, studies show that the adsorption that PVC class containers for medical use and conduit have multiple medicine in a large number, DEHP exists potential hazard that report is also arranged to HUMAN HEALTH.It is harmful that products such as the tubing that a lot of researchs are also found to be made by the PVC plastics, packing bag, blood bag, breathing mask, food bag are grown breeding to the mankind.And these products still are being widely used at present.All adopt in High Temperature Furnaces Heating Apparatus, to burn after polyvinyl chloride (PVC) medical infusion lines is used and handle, will produce like this human body and environment are disliked English for all deleterious two mouthfuls.Two mouthfuls to dislike the English toxicity very strong, is absorbed by the body by food such as beef, milk, fish etc. easily again.Therefore, relevant expert's suggestion should be used equivalent material as early as possible comprehensively.
Vinylbenzene-hydrogenated diene hydrocarbon block copolymer material totally nontoxic is thought by U.S. food Drug Administration (FDA), can not produce allergy, variation and rejection to tissue, have heatproof, ageing-resistant and uvioresistant performance, can use directly sterilization of high temperature steaming and ultraviolet ray, meet the food medical standard of promulgation.Therefore vinylbenzene-hydrogenated diene hydrocarbon copolymer the product of U.S. Shell Co. Ltd production obtained U.S. food Drug Administration (FDA) food medical treatment occupancy permit in 1980.This just illustrates that vinylbenzene-hydrogenated diene hydrocarbon block copolymer can be used as the base mateiral of producing medicine equipment.At present, abroad there are some successful examples in some companies on employing vinylbenzene-hydrogenated diene hydrocarbon block copolymer production medicine equipment, and related products comprise: tourniquet and blood separator etc.
Therefore, vinylbenzene-hydrogenated diene hydrocarbon block copolymer is to substitute the ideal basic material that PVC produces medical infusion lines.Yet number of research projects finds that vinylbenzene-hydrogenated diene hydrocarbon block copolymer can not be used for producing medical infusion lines separately.Its reason is to adopt the performance of the tubing of vinylbenzene-hydrogenated diene hydrocarbon block copolymer production to differ greatly with the PVC ratio, can not reach the use standard of present medical infusion lines at all.So a lot of researchists have adopted flexible method, a kind of is the medical infusion lines that adopts complicated explained hereafter multi-layer polymer film compound (it is vinylbenzene-hydrogenated diene hydrocarbon block copolymer that one deck is wherein arranged, as SEBS).Another kind is to adopt the simple physical blend alloy material of vinylbenzene-hydrogenated diene hydrocarbon block copolymer and other polymkeric substance (as PP and PE) to produce medical infusion lines.But, the over-all properties of the medical infusion lines that these two kinds of methods are produced is only close with the PVC medical infusion lines, can not meet or exceed the PVC medical infusion lines fully, and the performance that has is compared with PVC and still had huge spread, as the transparency, satisfy in the time of high temperature-resistant disinfected and mechanical property.Method based on above accommodation, the external non-PVC class material that is used to produce medical infusion lines of having released, yet because the gap on the tubing product performance, do not force to use the country of non-PVC class medical infusion lines at those, the promotion and application of present non-PVC class medical infusion lines are always because its performance deficiency and difficult.Can say so, up to the present, also develop the complete vinylbenzene-hydrogenated diene hydrocarbon block copolymer medical infusion tube material suitable on the performance in the world with PVC without any a company or research institution.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art, and a kind of non-polyvinyl chloride medical perfusion tube type material and manufacture method thereof of totally nontoxic are provided.The present invention adopts the medical infusion lines transparency of this material produce high, and snappiness is good, and anti-steam and xeothermic performance are better than polyvinyl chloride (PVC) medical infusion lines, and its mechanical property is better than the PVC medical infusion lines simultaneously.This kind medical infusion lines type material totally nontoxic can not produce allergy, variation and rejection to tissue, has heatproof, ageing-resistant and uvioresistant performance, can use directly sterilization of high temperature steaming and ultraviolet ray.This medical infusion lines type material can replace the medical infusion lines that polyvinyl chloride is used to produce various models fully.
Purpose of the present invention is realized by following technical measures:
A kind of non-polyvinyl chloride medical perfusion tube type material of totally nontoxic, it is to be made by following raw materials by weight percent: 100 parts of partially hydrogenated vinylbenzene-hydrogenated diene hydrocarbon block copolymer, low-molecular-weight ethylenic-propylene copolymer 5-200 part, natural oxidation inhibitor vitamin-E 0.01-10 part of modification.
Described partial hydrogenation is meant that the hydrogenation degree of vinylbenzene-hydrogenated diene hydrocarbon block copolymer is 50-99.6%;
The molecular weight of described partially hydrogenated vinylbenzene-hydrogenated diene hydrocarbon block copolymer is 30,000-40 between 0000, comprises linear di-block copolymer, the star di-block copolymer, one or more in linear triblock copolymer and the star triblock copolymer.
Diolefine in described partially hydrogenated vinylbenzene-hydrogenated diene hydrocarbon block copolymer is 1,3-butadiene and 2-methyl isophthalic acid, any in the 3-divinyl or several combinations.
The molecular weight of described low-molecular-weight ethylenic-propylene copolymer is 2, and 000-10 is between 000.
A kind of manufacture method of non-polyvinyl chloride medical perfusion tube type material of totally nontoxic, comprising the steps: to adopt partially hydrogenated vinylbenzene-hydrogenated diene hydrocarbon block copolymer is base mateiral, auxiliary material is that molecular weight is 2,000-10, the natural oxidation inhibitor vitamin-E of 000 low-molecular-weight ethylenic-propylene copolymer and modification, the utilization screw extrusion press carries out the serialization manufacturing; At first with the partially hydrogenated vinylbenzene-hydrogenated diene hydrocarbon block copolymer of 100 weight parts, the modified natural oxidation inhibitor vitamin-E of the low-molecular-weight ethylenic-propylene copolymer of 5-200 weight part and 0.01-10 weight part joins in the screw extrusion press after abundant compounding and makes continuously, and the processing temperature of screw extrusion press is 130-260 ℃.Adopted special local dynamic little crosslinking technological in the manufacturing processed, this technology relies on the little linking agent of the peroxide of 0.01-20 weight part together to join and implement local dynamic little crosslinking technological in the screw extrusion press earlier with after the basic material compounding, and perhaps the side loading mouth at the screw rod middle part adds and implements local dynamic little crosslinking technological.
The local dynamically little linking agent of little crosslinked peroxide that is adopted is 2,5-dimethyl-2,5 bis(t-butylperoxy) hexane, dicumyl peroxide, two tert-butyl peroxy diisopropylbenzene(DIPB)s, 2,5-dimethyl-2,5 bis(t-butylperoxy) acetylene, n-butyl-4,4-di-t-butyl peroxy valerate, 1,1-di-t-butyl peroxy-3,3,5-trimethyl-cyclohexane, m/p--2 (t-butylperoxy) diisopropylbenzene(DIPB), the special butyl ester of peroxidation phenylformic acid, di-t-butyl peroxide, the different pelargonate of tert-butyl peroxide, benzoyl peroxide, peroxidation uncle butyric acid 2-ethylhexyl, any in the dilauroyl peroxide or several combinations.
Described manufacture method is after adopting local dynamic little crosslinking technological, and the weight percent of the degree of crosslinking of this tubing type material is 0.02-15%.
The present invention has the following advantages:
The creationary partially hydrogenated vinylbenzene-hydrogenated diene hydrocarbon block copolymer that adopted of this medical infusion lines type material is that base mateiral is produced, auxiliary material is that molecular weight is 2,000-10, the natural oxidation inhibitor vitamin-E of 000 low-molecular-weight ethylenic-propylene copolymer and modification.This kind medical infusion lines type material adopts screw extrusion press to carry out serialization production, has adopted special dynamic little crosslinking technological in the production process.So-called local dynamic little crosslinking technological is exactly in the process of screw extrusion press blend, and " original position " carries out chemical bonding in the subrange of material matrix.Provide cross-linking set just because of two keys unnecessary in partially hydrogenated vinylbenzene-hydrogenated diene hydrocarbon block copolymer, and the dynamic little crosslinking technological in this part is achieved.Because this technology is not damaged its processing flowability when improving material property, so this medical infusion lines type material has the excellent comprehensive performance.Adopt the medical infusion lines transparency of this material produce high, snappiness is good, and anti-steam and xeothermic performance are better than polyvinyl chloride (PVC) medical infusion lines, and its mechanical property is better than the PVC medical infusion lines simultaneously.This kind medical infusion lines type material totally nontoxic can not produce allergy, variation and rejection to tissue, has heatproof, ageing-resistant and uvioresistant performance, can use directly sterilization of high temperature steaming and ultraviolet ray.This medical infusion lines type material can replace the medical infusion lines that polyvinyl chloride is used to produce various models fully, is just meeting an urgent demand that comprehensively substitutes the PVC material.
Therefore the performance and the PVC of the medical infusion lines produced of the non-polyvinyl chloride type material of this kind totally nontoxic are suitable fully, some performance even surpassed traditional PVC medical infusion lines has been filled up the blank in present non-polyvinyl chloride medical perfusion tube material field.And overcome all defect that the PVC material is used in the medical infusion lines field comprehensively, as toxicity, reclaim pollution etc.Next adopts this kind type material just can produce satisfactory medical infusion lines proembryo through disposable extruding, need not other additional process.Moreover production cost is moderate, and output is big, is easy to be accepted by market.
Specific implementation method
Embodiment 1
The non-polyvinyl chloride medical perfusion tube material of totally nontoxic adopts molecular weight 30,000 partially hydrogenated linear two block styrene-hydrogenation 1, the 3-butadiene block copolymer, auxiliary material is a molecular weight at 2,000 the low-molecular-weight ethylenic-propylene copolymer and the natural oxidation inhibitor vitamin-E of modification.The hydrogenation degree of linear two block styrene-hydrogenation 1,3-butadiene segmented copolymer is 50%.This kind medical infusion lines type material adopts co-rotating twin screw extruder to carry out the serialization manufacturing.Manufacture method is: with partially hydrogenated linear two block styrene-hydrogenation 1 of 100kg, the 3-butadiene block copolymer, the modification vitamin-E of the low-molecular-weight ethylenic-propylene copolymer of 5kg and 0.01kg joins co-rotating twin screw extruder and makes continuously after abundant compounding, the processing temperature of screw extrusion press is 130 ℃.Adopted special local dynamic little crosslinking technological in the manufacturing processed, this technology relies on 2 of 0.01kg, and 5-dimethyl-2,5 bis(t-butylperoxy) hexane is realized.In manufacturing processed, 2, together join after 5-dimethyl-2,5 bis(t-butylperoxy) hexane and the basic material compounding in the screw extrusion press and implement local dynamically little crosslinked.It is 0.02% that the final material that is obtained adopts dissolution method to measure its degree of crosslinking
Embodiment 2
The non-polyvinyl chloride medical perfusion tube material of totally nontoxic adopts molecular weight 40,0000 partially hydrogenated star two block styrene-hydrogenation 2-methyl isophthalic acid, the 3-butadiene block copolymer, auxiliary material is a molecular weight at 10,000 the low-molecular-weight ethylenic-propylene copolymer and the natural oxidation inhibitor vitamin-E of modification.Partially hydrogenated star two block styrene-hydrogenation 2-methyl isophthalic acid, the hydrogenation degree of 3-butadiene block copolymer is 99.6%.This kind medical infusion lines type material adopts Heterodromy double-screw extruder to carry out the serialization manufacturing.Manufacturing processed is: with partially hydrogenated star two block styrene-hydrogenation 2-methyl isophthalic acid of 100kg, the 3-butadiene block copolymer, the modification vitamin-E of the low-molecular-weight ethylenic-propylene copolymer of 200kg and 10kg joins Heterodromy double-screw extruder and makes continuously after abundant compounding, the processing temperature of screw extrusion press is 260 ℃.Adopted special local dynamic little crosslinking technological in the manufacturing processed, this technology relies on the dilauroyl peroxide of 20kg to realize.In manufacturing processed, dilauroyl peroxide adds and the local dynamic little crosslinking technological of enforcement from the side loading mouth at screw rod middle part.It is 15% that the final material that is obtained adopts dissolution method to measure its degree of crosslinking.
Embodiment 3
The non-polyvinyl chloride medical perfusion tube material of totally nontoxic adopts molecular weight 300,000 partially hydrogenated star three block styrene-hydrogenation 1, the 3-butadiene block copolymer, auxiliary material is a molecular weight at 6,000 the low-molecular-weight ethylenic-propylene copolymer and the natural oxidation inhibitor vitamin-E of modification.The hydrogenation degree of partially hydrogenated star three block styrene-hydrogenation 1,3-butadiene segmented copolymer is 90%.This kind medical infusion lines type material adopts four screw extruder to carry out the serialization manufacturing.Manufacturing processed is: with partially hydrogenated star three block styrene-hydrogenation 1 of 100kg, the 3-butadiene block copolymer, the modification vitamin-E of the low-molecular-weight ethylenic-propylene copolymer of 40kg and 10kg joins four screw extruder and makes continuously after abundant compounding, the processing temperature of screw extrusion press is 200 ℃.Adopted special local dynamic little crosslinking technological in the manufacturing processed, this technology relies on the special butyl ester of the peroxidation phenylformic acid of 4kg to realize.In manufacturing processed, the special butyl ester of peroxidation phenylformic acid adds and the local dynamic little crosslinking technological of enforcement from the side loading mouth at screw rod middle part.It is 6% that the final material that is obtained adopts dissolution method to measure its degree of crosslinking.
Embodiment 4
The non-polyvinyl chloride medical perfusion tube material of totally nontoxic adopts molecular weight 10,0000 partially hydrogenated linear three block styrene-hydrogenation 2-methyl isophthalic acid, the 3-butadiene block copolymer, auxiliary material is a molecular weight at 8,000 the low-molecular-weight ethylenic-propylene copolymer and the natural oxidation inhibitor vitamin-E of modification.Partially hydrogenated linear three block styrene-hydrogenation 2-methyl isophthalic acid, the hydrogenation degree of 3-butadiene block copolymer is 85%.This kind medical infusion lines type material adopts Heterodromy double-screw extruder to carry out the serialization manufacturing.Manufacturing processed is: with partially hydrogenated linear three block styrene-hydrogenation 2-methyl isophthalic acid of 100kg, the 3-butadiene block copolymer, the modification vitamin-E of the low-molecular-weight ethylenic-propylene copolymer of 80kg and 8kg joins Heterodromy double-screw extruder and makes continuously after abundant compounding, the processing temperature of screw extrusion press is 160 ℃.Adopted special local dynamic little crosslinking technological in the manufacturing processed, this technology relies on the benzoyl peroxide of 4kg to realize.In manufacturing processed, benzoyl peroxide adds and the local dynamic little crosslinking technological of enforcement from the side loading mouth at screw rod middle part.It is 3% that the final material that is obtained adopts dissolution method to measure its degree of crosslinking.
Embodiment 5
The non-polyvinyl chloride medical perfusion tube material of totally nontoxic adopts molecular weight 20,0000 partially hydrogenated star three block styrene-hydrogenation 2-methyl isophthalic acid, 3-butadiene block copolymer and partially hydrogenated linear two block styrene-hydrogenation 1, the 3-butadiene block copolymer, auxiliary material is a molecular weight at 3,000 the low-molecular-weight ethylenic-propylene copolymer and the natural oxidation inhibitor vitamin-E of modification.Partially hydrogenated star three block styrene-hydrogenation 2-methyl isophthalic acid, the hydrogenation degree of 3-butadiene block copolymer is 92%, the hydrogenation degree of partially hydrogenated linear two block styrene-hydrogenation 1,3-butadiene segmented copolymer is 60%.This kind medical infusion lines type material adopts co-rotating twin screw extruder to carry out the serialization manufacturing.Manufacturing processed is: with partially hydrogenated star three block styrene-hydrogenation 2-methyl isophthalic acid of 40kg, partially hydrogenated linear two block styrene of 3-butadiene block copolymer and 60kg-hydrogenation 1, the 3-butadiene block copolymer, the modification vitamin-E of the low-molecular-weight ethylenic-propylene copolymer of 10kg and 12kg joins co-rotating twin screw extruder and makes continuously after abundant compounding, the processing temperature of screw extrusion press is 190 ℃.Adopted special local dynamic little crosslinking technological in the manufacturing processed, this technology relies on 2 of 3kg, and 5-dimethyl-2,5 bis(t-butylperoxy) acetylene is realized.In manufacturing processed, 2,5-dimethyl-2,5 bis(t-butylperoxy) acetylene adds and the local dynamic little crosslinking technological of enforcement from the side loading mouth at screw rod middle part.It is 5% that the final material that is obtained adopts dissolution method to measure its degree of crosslinking.
Embodiment 6
The medical infusion lines of novel material manufacturing among the embodiment 1-5 and the fundamental property of general PVC medical infusion lines are compared.Wherein tensile strength and elongation at break all adopt American I nstra universal testing machine to measure.Shao's formula hardness adopts outstanding grace LX-D type duroplasts Shao formula sclerometer to measure.Anti-steam, anti-xeothermic property, vinyl chloride monomer and leachable are carried out according to the GB10010 standard.As shown in table 1, table 1 is the medical infusion lines and the general PVC medical infusion lines fundamental property test result of novel material manufacturing of the present invention.The performance and the PVC of medical infusion lines of non-polyvinyl chloride type material manufacturing that this shows this kind totally nontoxic is suitable fully, some performance even surpassed traditional PVC medical infusion lines has been filled up the blank in present non-polyvinyl chloride medical perfusion tube material field.And production cost is moderate, and output is big, is easy to be accepted by market.
Table 1
Claims (8)
1, a kind of non-polyvinyl chloride medical perfusion tube type material of totally nontoxic, it is characterized in that it is to be made by following raw materials by weight percent: 100 parts of partially hydrogenated vinylbenzene-hydrogenated diene hydrocarbon block copolymer, low-molecular-weight ethylenic-propylene copolymer 5-200 part, natural oxidation inhibitor vitamin-E 0.01-10 part of modification.
2, the non-polyvinyl chloride medical perfusion tube type material of totally nontoxic as claimed in claim 1 is characterized in that: described partial hydrogenation is meant that the hydrogenation degree of vinylbenzene-hydrogenated diene hydrocarbon block copolymer is 50-99.6%.
3, the non-polyvinyl chloride medical perfusion tube type material of totally nontoxic as claimed in claim 2, it is characterized in that: the molecular weight of described partially hydrogenated vinylbenzene-hydrogenated diene hydrocarbon block copolymer is 30,000-40, between 0000, comprise linear di-block copolymer, the star di-block copolymer, one or more in linear triblock copolymer and the star triblock copolymer.
4, the non-polyvinyl chloride medical perfusion tube type material of totally nontoxic as claimed in claim 3, it is characterized in that: the diolefine in described partially hydrogenated vinylbenzene-hydrogenated diene hydrocarbon block copolymer is 1,3-divinyl and 2-methyl isophthalic acid, any in the 3-divinyl or several combinations.
5, the non-polyvinyl chloride medical perfusion tube type material of totally nontoxic as claimed in claim 1 is characterized in that: the molecular weight of described low-molecular-weight ethylenic-propylene copolymer is 2, and 000-10 is between 000.
6, a kind of manufacture method of non-polyvinyl chloride medical perfusion tube type material of totally nontoxic as claimed in claim 1, it is characterized in that comprising the steps: to adopt partially hydrogenated vinylbenzene-hydrogenated diene hydrocarbon block copolymer is base mateiral, auxiliary material is that molecular weight is 2,000-10, the natural oxidation inhibitor vitamin-E of 000 low-molecular-weight ethylenic-propylene copolymer and modification, the utilization screw extrusion press carries out the serialization manufacturing; At first with the partially hydrogenated vinylbenzene-hydrogenated diene hydrocarbon block copolymer of 100 weight parts, the modified natural oxidation inhibitor vitamin-E of the low-molecular-weight ethylenic-propylene copolymer of 5-200 weight part and 0.01-10 weight part joins in the screw extrusion press after abundant compounding and makes continuously, and the processing temperature of screw extrusion press is 130-260 ℃; Adopted special local dynamic little crosslinking technological in the manufacturing processed, this technology relies on the little linking agent of the peroxide of 0.01-20 weight part together to join and implement local dynamic little crosslinking technological in the screw extrusion press earlier with after the basic material compounding, and perhaps the side loading mouth at the screw rod middle part adds and implements local dynamic little crosslinking technological.
7, the manufacture method of the non-polyvinyl chloride medical perfusion tube type material of totally nontoxic as claimed in claim 6, it is characterized in that: the local dynamically little linking agent of little crosslinked peroxide that is adopted is 2,5-dimethyl-2,5 bis(t-butylperoxy) hexanes, dicumyl peroxide, two tert-butyl peroxy diisopropylbenzene(DIPB)s, 2,5-dimethyl-2,5 bis(t-butylperoxy) acetylene, n-butyl-4,4-di-t-butyl peroxy valerate, 1,1-di-t-butyl peroxy-3,3, the 5-trimethyl-cyclohexane, m/p-2 (t-butylperoxy) diisopropylbenzene(DIPB), the special butyl ester of peroxidation phenylformic acid, di-t-butyl peroxide, the different pelargonate of tert-butyl peroxide, benzoyl peroxide, peroxidation uncle butyric acid 2-ethylhexyl, any in the dilauroyl peroxide or several combinations.
8, the manufacture method of the non-polyvinyl chloride medical perfusion tube type material of totally nontoxic as claimed in claim 7, it is characterized in that: described manufacture method is after adopting local dynamic little crosslinking technological, and the weight percent of the degree of crosslinking of this tubing type material is 0.02-15%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100966800A CN101525464B (en) | 2009-03-12 | 2009-03-12 | Novel material for totally nontoxic non-polyvinyl chloride medical perfusion tube and method for manufacturing same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100966800A CN101525464B (en) | 2009-03-12 | 2009-03-12 | Novel material for totally nontoxic non-polyvinyl chloride medical perfusion tube and method for manufacturing same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101525464A true CN101525464A (en) | 2009-09-09 |
| CN101525464B CN101525464B (en) | 2011-04-20 |
Family
ID=41093542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009100966800A Expired - Fee Related CN101525464B (en) | 2009-03-12 | 2009-03-12 | Novel material for totally nontoxic non-polyvinyl chloride medical perfusion tube and method for manufacturing same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101525464B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102093661A (en) * | 2011-01-13 | 2011-06-15 | 岳阳雅达塑胶有限公司 | Low-hardness, halogen-free and flame-retarding elastomer material and preparation method thereof |
| CN109504024A (en) * | 2018-12-06 | 2019-03-22 | 中国科学院长春应用化学研究所 | A kind of SEBS basal granule material, preparation method, infusion apparatus extruded film and infusion apparatus |
| CN109517206A (en) * | 2018-12-06 | 2019-03-26 | 中国科学院长春应用化学研究所 | A kind of SEBS group compound film, preparation method and infusion apparatus |
| CN109735042A (en) * | 2018-12-28 | 2019-05-10 | 成都兢鹏生化科技有限公司 | A kind of medical AMTPS material, medical instrument and preparation method |
-
2009
- 2009-03-12 CN CN2009100966800A patent/CN101525464B/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102093661A (en) * | 2011-01-13 | 2011-06-15 | 岳阳雅达塑胶有限公司 | Low-hardness, halogen-free and flame-retarding elastomer material and preparation method thereof |
| CN102093661B (en) * | 2011-01-13 | 2012-12-26 | 岳阳雅达塑胶有限公司 | Low-hardness, halogen-free and flame-retarding elastomer material and preparation method thereof |
| CN109504024A (en) * | 2018-12-06 | 2019-03-22 | 中国科学院长春应用化学研究所 | A kind of SEBS basal granule material, preparation method, infusion apparatus extruded film and infusion apparatus |
| CN109517206A (en) * | 2018-12-06 | 2019-03-26 | 中国科学院长春应用化学研究所 | A kind of SEBS group compound film, preparation method and infusion apparatus |
| CN109735042A (en) * | 2018-12-28 | 2019-05-10 | 成都兢鹏生化科技有限公司 | A kind of medical AMTPS material, medical instrument and preparation method |
| CN109735042B (en) * | 2018-12-28 | 2021-11-16 | 四川洁凯医疗器械有限公司 | Medical AMTPS material, medical instrument and preparation method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101525464B (en) | 2011-04-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107283980B (en) | A kind of digestion resistant polyethylene film and its production technology | |
| CN101525464B (en) | Novel material for totally nontoxic non-polyvinyl chloride medical perfusion tube and method for manufacturing same | |
| EP1340782B1 (en) | Toughened plastics and its preparation method | |
| CN104449470B (en) | A kind of for adhering resin intercepting composite soft tube and preparation method and application | |
| CN104371597B (en) | A kind of preparation method of multi-layer co-extruded barrier package polypropylene adhering resin | |
| CN104356977A (en) | Preparation method of adhesive resin for multilayer coextruded plastic composite hose | |
| CN102911475A (en) | Medical artificial rubber material and preparation method thereof | |
| JP2014101403A (en) | Heat resistant styrenic resin composition, extruded sheet and molded article | |
| CN104327347A (en) | High-molecular bonding resin used for non-PVC medical transfusion bag and preparation method thereof | |
| CN104448739A (en) | Composite medical chitosan/ polycaprolactone film and preparation method thereof | |
| WO2023142684A1 (en) | Degradable thin film of disposable bag for biopharmacy and use thereof | |
| CN101676309B (en) | Functionalized polypropylene for flexible packages, preparation method thereof and functionalized polypropylene used for preparing flexible packages by the method | |
| CN108003547A (en) | Medical TPE sealing materials of heat resistant type and preparation method thereof | |
| CN102276906B (en) | Modified ethane-vinyl alcohol copolymer composite material and preparation technology thereof | |
| CN104403281B (en) | A kind of medical fibre based high molecular material and its preparation method | |
| CN114437446B (en) | Preparation method of dummy rib material suitable for Chinese collision test | |
| CN105131472A (en) | Preparation method of anti-fogging medical film having sterilizing function | |
| CN105482291A (en) | Ageing-proof PVC film for packaging, and making method thereof | |
| US3513226A (en) | Vinylidene chloride copolymer compositions | |
| CN109735042A (en) | A kind of medical AMTPS material, medical instrument and preparation method | |
| CN109467870A (en) | A kind of low smell highly resistance, which is leapt high, flows ABS resin and preparation method thereof | |
| CN108912630A (en) | A kind of easily peelable environment-friendlythin thin film and its technique for adsorbing bamboo chopsticks | |
| CN108329646A (en) | A kind of highly resistance is leapt high flowing ABS resin and preparation method thereof | |
| CN107418030A (en) | A kind of high-temperature-resistant high wood plastic composite and preparation method thereof | |
| CN105061931B (en) | A kind of PVC granular material in medical use suitable for steam sterilizing |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110420 Termination date: 20180312 |