CN101525356A - Amino glucose cosmetic material and preparation method thereof - Google Patents
Amino glucose cosmetic material and preparation method thereof Download PDFInfo
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- CN101525356A CN101525356A CN200910111508A CN200910111508A CN101525356A CN 101525356 A CN101525356 A CN 101525356A CN 200910111508 A CN200910111508 A CN 200910111508A CN 200910111508 A CN200910111508 A CN 200910111508A CN 101525356 A CN101525356 A CN 101525356A
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Abstract
The invention provides an amino glucose cosmetic material and a preparation method thereof, and relates to a cosmetic material, in particular to an amino glucose cosmetic material with the effects of preserving moisture and removing wrinkles at the same time and a preparation method thereof. The preparation method comprises the following steps: adding sulfate into amino glucose water solution free of potassium, sodium or chlorine, stirring the water solution to form mixed solution A, adding 1 to 4 times of solvent in volume of the mixed solution A into the mixed solution A according to volume ratio, stirring the mixed solution, and standing the mixed solution to form mixed solution B; pouring out supernatant clear fluid to obtain sticky solution, adding 3 to 6 times of solvent in volume of the sticky solution into the sticky solution according to volume ratio, stirring the mixed solution till separating out solid, filtering the mixed solution, and drying the solid to obtain a white solid product, namely, the amino glucose cosmetic material.
Description
Technical field
The present invention relates to a kind of cosmetics material, especially relate to a kind of have simultaneously the amino glucose cosmetic material of preserving moisture and removing the wrinkle effect and preparation method thereof.
Background technology
Glucosamine is a kind of specifics of widely used treatment osteoarthritis; mainly contain the product of following several forms: glucosamine hydrochloride, Glucosamine Sulphate, glucosamine potassium sulfate (sodium) salt and N-acetylamino glucose; at present glucosamine is mainly used in the treatment of osteoarthritis, and particularly the applied research aspect the makeup is few in others.People's (U.S. Pat 2007/0092469) such as U.S. scientist Eric Jacob find that glucosamine has the skin of promotion hyaluronic acid and produces, reduces effects such as wrinkle, for Glucosamine Sulphate has been laid theoretical basis in the application aspect the makeup.In addition, some researchs of the U.S. prove that also glucosamine has the effect of improving skin quality, desalination color spot.At present, what the glucosamine that has gone on the market mainly contained Olay and SK-II removes the wrinkle serial cosmetics, but is raw material with N-acetylamino glucose mainly, and the cosmetic product of other glucosamine class does not appear in the newspapers at present.Do not contain the Glucosamine Sulphate of potassium, sodium, chlorine because its purity height and hyaluronic acid generate advantage faster, be easily absorbed by the body, in the treatment of osteoarthritis than other glucosamine better effects if, also continue the working lipe that joint cartilage is repaired more of a specified duration, but because it absorbs water and oxidizing brown stain easily, can only be used for the treatment of osteoarthritis now with the capsule preparations form, limit its application in other field.
Summary of the invention
The object of the present invention is to provide a kind of amino glucose cosmetic material and preparation method thereof.
Technical scheme of the present invention is to be raw material with the Glucosamine Sulphate that does not contain potassium, sodium, chlorine, adds vitriol, to strengthen amino ionization, alleviates the shortcoming of the easy oxidizing brown stain of product.
The molecular formula of amino glucose cosmetic material of the present invention is:
When A=1, M
xBe K
+Or Mg
2+When A=2, M
xBe respectively Na
+, K
+Or Mg
2+The glucosamine ammonium salt:
Abbreviate GSH as
+
The preparation method's of amino glucose cosmetic material of the present invention concrete steps are as follows:
Vitriol is joined in the Glucosamine Sulphate aqueous solution that does not contain potassium, sodium, chlorine, stir, get mixed solution A, by volume, add the solvent of 1～4 times of mixed solution A volume, leave standstill after the stirring, get mixing solutions B; After pouring out supernatant liquid, obtain thick solution, by volume, add the solvent of 3～6 times of thick liquor capacities, be stirred to solid and separate out, after the filtration, the dry white solid product amino glucose cosmetic material that gets.
Described vitriol can be sodium sulfate, vitriolate of tartar or sal epsom etc., and described Glucosamine Sulphate is not for containing the Glucosamine Sulphate of potassium, sodium, chlorion, and Glucosamine Sulphate aqueous solution concentration by mass percentage is preferably 15%～30%.Describedly vitriol is joined the Glucosamine Sulphate solution that does not contain potassium, sodium, chlorine preferably add with solid state vitriol, in molar ratio, the add-on of vitriol is preferably vitriol: Glucosamine Sulphate is (0.5～1): 1.Described vitriol is joined in the Glucosamine Sulphate solution that does not contain potassium, sodium, chlorine, the time of stirring is preferably 3～6h.The solvent of 1～4 times of mixed solution A volume of described adding is preferably ethanol or acetone etc.The described solvent that adds 3～6 times of thick liquor capacities behind the supernatant liquid of pouring out is preferably ethanol or acetone etc.
The present invention is a starting raw material with the Glucosamine Sulphate that does not contain potassium, sodium, chlorine, vitriol with sodium, potassium, magnesium reacts respectively, the Glucosamine Sulphate double salt that obtains, purity reaches more than 99%, have moisture retention and the effect of removing wrinkle preferably, hyaluronic acid generates very fast, relatively is difficult for oxidizing brown stain, is the good cosmetic material of a kind of potential.In addition, the preparation method is simple, is fit to suitability for industrialized production.
Embodiment
The following examples can make those skilled in the art more fully understand the present invention, but do not limit the present invention in any way.
Embodiment 1
With sodium sulfate crystal (21.5g, 0.15mol) be dissolved in 30% the Glucosamine Sulphate solution (456.2g), magnetic stirring apparatus adds the acetone solvent of 500mL at stirring at room 4h, leave standstill after stirring to two and be separated, pour out supernatant liquid, add the acetone solvent of 300mL again, vigorous stirring to white solid is separated out fully, after filtering fast, vacuum-drying gets white solid product 147.0g (productive rate, 93%), molecular formula 2 (GSH
+)
2SO
4 2-Na
2 +SO
4 2-
The Glucosamine Sulphate product that does not contain potassium, sodium, chlorine that described Glucosamine Sulphate can adopt Xiamen Blue Bay Science and Technology Co., Ltd. to produce.
Embodiment 2
With potassium sulfate crystal (26.0g, 0.15mol) be dissolved in 30% the Glucosamine Sulphate solution (456.4g), magnetic stirring apparatus adds the acetone solvent of 500mL at stirring at room 3.5h, leave standstill after stirring to two and be separated, pour out supernatant liquid, add the acetone solvent of 300mL again, vigorous stirring to white solid is separated out fully, after filtering fast, vacuum-drying gets white solid product 154.8g (productive rate, 95%), molecular formula 2 (GSH
+)
2SO
4 2-K
2 +SO
4 2-
Embodiment 3
With sodium sulfate crystal (21.2g, 0.15mol) be dissolved in 30% the Glucosamine Sulphate solution (455.8g), magnetic stirring apparatus adds the alcohol solvent of 1000mL at stirring at room 5h, leave standstill after stirring to two and be separated, pour out supernatant liquid, add the alcohol solvent of 500mL again, vigorous stirring to white solid is separated out fully, after filtering fast, vacuum-drying gets white solid product 142.3g (productive rate, 90%), molecular formula 2 (GSH
+)
2SO
4 2-Na
2 +SO
4 2-
Embodiment 4
With magnesium sulfate crystals (17.8g, 0.15mol) be dissolved in 30% the Glucosamine Sulphate solution (456.5g), magnetic stirring apparatus adds the alcohol solvent of 500mL at stirring at room 3h, leave standstill after stirring to two and be separated, pour out supernatant liquid, add the acetone solvent of 300mL again, vigorous stirring to white solid is separated out fully, after filtering fast, vacuum-drying gets white solid product 142.4g (productive rate, 92%), molecular formula 2 (GSH
+)
2SO
4 2-Mg
2+SO
4 2-
Embodiment 5
With sodium sulfate crystal (10.4g, 0.075mol) be dissolved in 15% the Glucosamine Sulphate solution (456.3g), magnetic stirring apparatus adds the acetone solvent of 1600mL at stirring at room 6h, leave standstill after stirring to two and be separated, pour out supernatant liquid, add the acetone solvent of 900mL again, vigorous stirring to white solid is separated out fully, after filtering fast, vacuum-drying gets white solid product 64.8g (productive rate, 82%), molecular formula 2 (GSH
+)
2SO
4 2-Na
2 +SO
4 2-
Embodiment 6
With sodium sulfate crystal (10.4g, 0.075mol) be dissolved in 20% the Glucosamine Sulphate solution (341.9g), magnetic stirring apparatus adds the alcohol solvent of 700mL at stirring at room 5.5h, leave standstill after stirring to two and be separated, pour out supernatant liquid, add the alcohol solvent of 400mL again, vigorous stirring to white solid is separated out fully, after filtering fast, vacuum-drying gets white solid product 67.2g (productive rate, 85%), molecular formula 2 (GSH
+)
2SO
4 2-Na
2 +SO
4 2-
Embodiment 7
With potassium sulfate crystal (26.0g, 0.15mol) be dissolved in 26% the Glucosamine Sulphate solution (456.4g), magnetic stirring apparatus adds the acetone solvent of 900mL at stirring at room 3.5h, leave standstill after stirring to two and be separated, pour out supernatant liquid, add the acetone solvent of 300mL again, vigorous stirring to white solid is separated out fully, after filtering fast, vacuum-drying gets white solid product 154.8g (productive rate, 95%), molecular formula 2 (GSH
+)
2SO
4 2-K
2 +SO
4 2-
Embodiment 8
With potassium sulfate crystal (34.8g, 0.20mol) be dissolved in 19% the Glucosamine Sulphate solution (480.2g), magnetic stirring apparatus adds the alcohol solvent of 1500mL at stirring at room 4h, leave standstill after stirring to two and be separated, pour out supernatant liquid, add the alcohol solvent of 500mL again, vigorous stirring to white solid is separated out fully, after filtering fast, vacuum-drying gets white solid product 114.6g (productive rate, 91%), molecular formula (GSH
+)
2SO
4 2-K
2 +SO
4 2-
Embodiment 9
With potassium sulfate crystal (35.0g, 0.21mol) be dissolved in 15% the Glucosamine Sulphate solution (610.0g), magnetic stirring apparatus adds the alcohol solvent of 2400mL at stirring at room 6h, leave standstill after stirring to two and be separated, pour out supernatant liquid, add the acetone solvent of 600mL again, vigorous stirring to white solid is separated out fully, after filtering fast, vacuum-drying gets white solid product 103.3g (productive rate, 82%), molecular formula (GSH
+)
2SO
4 2-K
2 +SO
4 2-
Embodiment 10
With magnesium sulfate crystals (24.1g, 0.19mol) be dissolved in 15% the Glucosamine Sulphate solution (609.8g), magnetic stirring apparatus adds the acetone solvent of 2400mL at stirring at room 6h, leave standstill after stirring to two and be separated, pour out supernatant liquid, add the acetone solvent of 700mL again, vigorous stirring to white solid is separated out fully, after filtering fast, vacuum-drying gets white solid product 103.3g (productive rate, 82%), molecular formula (GSH
+)
2SO
4 2-Mg
2+SO
4 2-
Embodiment 11
With magnesium sulfate crystals (24.3g, 0.20mol) be dissolved in 21% the Glucosamine Sulphate solution (434.2g), magnetic stirring apparatus adds the alcohol solvent of 800mL at stirring at room 4.5h, leave standstill after stirring to two and be separated, pour out supernatant liquid, add the acetone solvent of 400mL again, vigorous stirring to white solid is separated out fully, after filtering fast, vacuum-drying gets white solid product 113.4g (productive rate, 90%), molecular formula (GSH
+)
2SO
4 2-Mg
2+SO
4 2-
Embodiment 12
With magnesium sulfate crystals (24.9g, 0.21mol) be dissolved in 30% the Glucosamine Sulphate solution (319.5g), magnetic stirring apparatus adds the alcohol solvent of 1000mL at stirring at room 3h, leave standstill after stirring to two and be separated, pour out supernatant liquid, add the acetone solvent of 350mL again, vigorous stirring to white solid is separated out fully, after filtering fast, vacuum-drying gets white solid product 118.0g (productive rate, 94%), molecular formula (GSH
+)
2SO
4 2-Mg
2+SO
4 2-
Claims (9)
1. amino glucose cosmetic material is characterized in that its molecular formula is:
When A=1, M
xBe K
+Or Mg
2+When A=2, M
xBe respectively Na
+, K
+Or Mg
2+
2. the preparation method of a kind of amino glucose cosmetic material as claimed in claim 1 is characterized in that concrete steps are as follows:
Vitriol is joined in the Glucosamine Sulphate aqueous solution that does not contain potassium, sodium, chlorine, stir, get mixed solution A, by volume, add the solvent of 1～4 times of mixed solution A volume, leave standstill after the stirring, get mixing solutions B; After pouring out supernatant liquid, obtain thick solution, by volume, add the solvent of 3～6 times of thick liquor capacities, be stirred to solid and separate out, after the filtration, the dry white solid product amino glucose cosmetic material that gets.
3. the preparation method of a kind of amino glucose cosmetic material as claimed in claim 2 is characterized in that described vitriol is sodium sulfate, vitriolate of tartar or sal epsom.
4. the preparation method of a kind of amino glucose cosmetic material as claimed in claim 2, it is characterized in that described Glucosamine Sulphate for not containing the Glucosamine Sulphate of potassium, sodium, chlorion, Glucosamine Sulphate aqueous solution concentration by mass percentage is 15%～30%.
5. the preparation method of a kind of amino glucose cosmetic material as claimed in claim 2 is characterized in that the described Glucosamine Sulphate solution that does not contain potassium, sodium, chlorine that vitriol is joined adds with solid state vitriol.
6. as the preparation method of claim 2 or 3 described a kind of amino glucose cosmetic materials, it is characterized in that in molar ratio that the add-on of vitriol is a vitriol: Glucosamine Sulphate is (0.5～1): 1.
7. the preparation method of a kind of amino glucose cosmetic material as claimed in claim 2 is characterized in that described vitriol being joined in the Glucosamine Sulphate solution that does not contain potassium, sodium, chlorine, and the time of stirring is 3～6h.
8. the preparation method of a kind of amino glucose cosmetic material as claimed in claim 2 is characterized in that the solvent of 1～4 times of mixed solution A volume of described adding is ethanol or acetone.
9. the preparation method of a kind of amino glucose cosmetic material as claimed in claim 2 is characterized in that described to pour out the solvent that adds 3～6 times of thick liquor capacities behind the supernatant liquid be ethanol or acetone.
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|---|---|---|---|
| CN200910111508A CN101525356A (en) | 2009-04-18 | 2009-04-18 | Amino glucose cosmetic material and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910111508A CN101525356A (en) | 2009-04-18 | 2009-04-18 | Amino glucose cosmetic material and preparation method thereof |
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|---|---|
| CN101525356A true CN101525356A (en) | 2009-09-09 |
Family
ID=41093448
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103126063A (en) * | 2011-11-23 | 2013-06-05 | 福建中烟工业有限责任公司 | Novel tobacco sense organ humectant and using method thereof in tobacco |
-
2009
- 2009-04-18 CN CN200910111508A patent/CN101525356A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103126063A (en) * | 2011-11-23 | 2013-06-05 | 福建中烟工业有限责任公司 | Novel tobacco sense organ humectant and using method thereof in tobacco |
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Open date: 20090909 |