CN101522234A - Systems, devices and methods for fluid/drug delivery - Google Patents
Systems, devices and methods for fluid/drug delivery Download PDFInfo
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- CN101522234A CN101522234A CNA2007800339432A CN200780033943A CN101522234A CN 101522234 A CN101522234 A CN 101522234A CN A2007800339432 A CNA2007800339432 A CN A2007800339432A CN 200780033943 A CN200780033943 A CN 200780033943A CN 101522234 A CN101522234 A CN 101522234A
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Abstract
Fluid delivery systems, methods and devices for delivering a therapeutic fluid to the body of the patient are disclosed. A fluid delivery device (100) for delivering fluid to the body of the patient includes a housing having an upper wall (534) and a lower wall (536), wherein the upper wall includes an upper opening (116) and the lower wall includes a lower opening (540), a well-arrangement mechanism (510) configured to be disposed inside the housing and between the upper wall and the lower wall and including a tubular member (322) having a bore (326), wherein the bore is configured to be disposed between the upper opening and the lower opening, and a penetrating cartridge (662) for delivery of therapeutic fluid to the body of the patient, wherein the penetrating cartridge is configured toengage the bore following its insertion through the upper opening and the lower opening, wherein therapeutic fluid is configured to be delivered through the tubular member into the penetrating cartri dge into the body of the patient when the penetrating cartridge engages the bore.
Description
The cross reference of related application
The U.S. Provisional Application No.60/833 that the application requires Yodfat to submit on July 24th, 2006,110 and the U.S. Provisional Application No.60/837 that submits on August 14th, 2006 of Yodfat, 877 priority, the whole contents of these applications is incorporated into this as quoting.
Technical field
The present invention relates to be used for system, the apparatus and method of treatment fluid to patient (patient) conveying more specifically, are related to portable infusion apparatus (for example pump).Some embodiments of the present invention relate to infusion set, and it can directly be adhered on patient's the skin.Some embodiments of the present invention are paid close attention to a kind of " well device (well-arrangement) ", and it links the liquid reservoir (container) from infusion set fluid delivery tube that stretches out and the intubate that is used for the subcutaneous insertion of patient body.
Background technology
The fluidic traditional subcutaneous delivery device of treatment that enters patient body is also referred to as the portable infusion pump of revocable " similar pager ", and it mainly is used to successive insulin and carries.Typically, the pump of these similar pagers is attached to and is fixed on patient's belt on one's body.Then, long carrier pipe is connected with the liquid reservoir in the described device, also is connected with the subcutaneous intubate of infusion set.
In order to carry medicine continuously and to have developed traditional on-fixed infusion pump to the patient.These revocable infusion pump comprise liquid reservoir usually and are used for carrying to the subcutaneous intubate of infusion set the long tube of medicine.Described intubate is inserted into the sharp-pointed member that penetrates usually.The example of such infusion pump is in U.S. Patent No. 6,423, is disclosed in 035 and No.8,872,200.
Be disclosed in other examples patent below of traditional fluid infusion apparatus.The U.S. Patent No. 6,830,562 of the U.S. Patent No. 6,093,172 of Funderburk etc. and Mogensen etc. discloses a kind of spring of the automatic subcutaneous placement that is used for infusion set that comprises and has loaded the injection device of piston.The U.S. Patent No. 6,699 of Flaherty etc., but 218 a kind of device that is used for skin adherence that fluid is carried to the patient is disclosed, and it comprises the outer housing with fluid storage compartment.Described fluid storage compartment be used for fluid is communicated with by the allotter fluid that limited amount distributes to spout assembly from liquid reservoir, fluid medicine is discharged from described spout assembly, and enters patient body.Device in the patent of Flaherty also can be realized automatic intubate insertion.By using the greatly relative heavier and bigger parts of expanding unit size, such insertion can realize.
After inserting, do not consider the motion of patient body or the relative motion between pump outer housing and the intubate, intubate stably remains on its subcutaneous position.But this has caused all difficulties of the infusion set of skin adherence.
Another problem of present infusion set comprises that some patient is unwilling to stick a needle into themselves skin.Such patient uses automatic-inserting device to solve described problem usually.Other patient prefers manually inserting method.
Some shortcomings to traditional apparatus and method of patient's conveyance fluid are summarized as follows:
Long pipeline: in the insulin pump of common similar pager, long fluid delivery tube is easy to fold, knot, break and/or separate.In addition, such pipe is considered thoughtful and restriction patient's behavior.
Inflexible intubate connects: but in the pump of traditional skin adherence, intubate is connected rigidly with outer housing, and like this, the moving suddenly of patient body will cause the patient uncomfortable and intubate is separated with the patient and/or separate with the outer housing that installs.
Insert mechanism: some traditional insertion mechanisms are bonded in the device outer housing.Such device is heavier relatively and bigger, and (3-4 days usually) are carried by user during whole operation.
The intubate of single hop: the intubate of the pre-installation in some present infusion sets only has a section of predetermined length.
The fixing angle of inserting: in the device of some traditional similar pagers, the patient can only insert infusion set with single predetermined angle of penetration, and described angle of penetration is generally 30 °, 45 ° or 90 °.
Therefore, expectation provides a kind of system, device and/or method, to solve the problem above-mentioned of traditional fluid delivery system.Especially, expectation provides a kind of subcutaneous intubate that can be implemented in the maximum flexibility ratio of selecting on intubation length, inserted mode and the angle of penetration of patient to insert.
Summary of the invention
Some embodiments of the present invention relate to portable fluid delivery system and the device and method that is used to deliver the fluid to the patient.Such system allows the intubate use not need the independence " insert " of carrying after intubate is inserted and passes through " well device " and insert.The present invention also allows user to select multiple intubation length and/or inserts angle.
In some embodiments of the invention, but by use have pump and be used for the treatment of the conveyer device of the skin adherence of fluidic liquid reservoir, device that fluid between the carrier pipe of drawing from described liquid reservoir and the intubate that is used to the pipe is provided and insert the patient hypodermically is communicated with, can avoid using long tubing.In certain embodiments, the described device that is used to provide fluid to be communicated with is called as " well device ".
Some embodiments of the present invention provide greater flexibility by the required angle of penetration (for example spending about 90 degree (or bigger) from about 0) that realizes selecting for the patient for the patient.The present invention can be set to by preventing separating and treating the interruption of fluid to patient's supply of infusion set and intubate, thereby does not limit patient movement, and offers the better safety of patient.
Some embodiments of the present invention can realize:
Well device delivery pipe and the fluid between the intubate by means of special use are communicated with;
The variation of angle of penetration (for example 0 to 90 degree (or bigger));
Automatic and the manual subcutaneous insertion of intubate;
Relatively moving between intubate and the pump is so that intubate mobile insensitive to the pump outer housing.
In certain embodiments, carrier pipe is communicated with the intubate fluid by Connection Element, and described Connection Element is called as the well device.Described device comes into question in common unsettled, total Israel patent application No.171813, and its disclosure is incorporated into this by its integral body is quoted.Described well device can be realized the insertion of needle assembly, and described assembly comprises and penetrates member (for example pin) and intubate.After in thrusting skin, then insert intubate and extract pin out, the fluid connection between carrier pipe, intubate and the subcutaneous tissue is promptly set up and is kept.
In certain embodiments, described well device thereon side can comprise and can be set to the openings/apertures that is used to load.The patient can fill liquid reservoir and carrier pipe.By observing the fluid drop in the openings/apertures, the patient can know does not have bubble to stay in the system.After in thrusting patient's skin, openings/apertures can be set to by rubber cap and seal.Described rubber cap can be attached on the intubate, to prevent the leakage in the device operating process.The downside of well can be set to by rubber septum and close.In thrusting the process of skin, the rubber septum of bottom is needled into, and rubber cap seals up upper opening/hole simultaneously.Use the well equipment mechanism, the present invention also can be set to fluid delivery tube is connected with intubate.
In certain embodiments, described well device can be set to unsteady arrangement form and be connected with the outer housing of fluid delivery system.Especially, use described arrangement form, relatively moving between intubate and the outer housing can be allowed, thereby it is uncomfortable and/or eliminated the isolating probability of intubate to have reduced the patient who does not expect.
In certain embodiments, described well device comprises tubular element, and it can be provided with and be used for the cross walkway that intubate is inserted.Vertical sidepiece path that described cross walkway can be set to by being arranged in the described tubular element is communicated with the carrier pipe fluid.The zone of the described well of reception of outer housing can be set to and/or be provided with to be of a size of can realize the pressure rotation of tubular element along its longitudinal axis.Therefore by means of this set, anyone can change the inclination angle of cross walkway with respect to patient skin, and penetrates member and thrust the angle that skin and intubate be inserted into and can be changed.Penetrating assembly can be set to by means of special instrument (for example " insert ", a kind of such insert is described below) and manually or automatically be inserted in the tubular element.Tubular element can be above-described " floating " form.
In certain embodiments, be used for treatment FLUID TRANSPORTATION to the fluid delivery system of patient body is provided, and can be set to the module unit that comprises have single use portion (disposable portion) and reusable part.Single use portion can be set to and comprise the first wall that is arranged at described single use portion and the well device between second wall.First aperture can be arranged in the first wall, and second aperture can be arranged in second wall.The well device can comprise tubular element, and described tubular element has the side path between hole, the inlet that is communicated with the carrier pipe fluid and described inlet and the described hole.
In the above embodiments, tubular element can be set to rotatable, so that described hole can be positioned a plurality of positions.
Some embodiments of the present invention comprise the tube that penetrates that is used in the fluid delivery system.Penetrating tube can be set to and comprise main part, intubate and be suitable for thrusting the member that penetrates in patient's the skin.Main part comprises and is used to second chamber that receives fluidic first chamber and be communicated with the intubate and first chamber.
In yet another embodiment, be used for the treatment FLUID TRANSPORTATION can be set to the fluid delivery system of patient body and comprise that the fluid delivery system with module unit, described module unit comprise single use portion and reusable part.Single use portion comprise first wall, have second wall, the fluid delivery tube in second aperture and be arranged at first wall with first aperture and second wall between the well device.Described well device can comprise the tubular element of the inlet that has the hole, be communicated with the carrier pipe fluid and the side path between inlet and hole.Tubular element can be rotatable, so that described hole can be positioned a plurality of positions of first and/or second wall vertical (for example) of described relatively single use portion.Described system also can comprise the tube that penetrates in the hole that can be received in tubular element, and wherein, the described tube that penetrates can comprise intubate and the member that penetrates that is suitable for thrusting in the patient skin.The main part that penetrates tube can comprise and is used to second chamber that receives fluidic first chamber and be communicated with intubate and described first chamber.
Can comprise " insert " instrument in the some embodiments of the present invention, with as being used for penetrating the device that assembly (" penetrating tube ") automatically inserts tubular element.Described insert instrument can penetrate tube by patient or maker preloaded before insertion.User can make the insert instrument align with cross walkway, and discharges the tube that penetrates of preloaded by the button that promotes actuator.
Tubular element and insert instrument can be provided with separately be pressed into groove and projection, thereby can realize insert instrument and tubular element make things convenient for interlock (joint), and penetrate aliging accurately of member and cross walkway.
In certain embodiments, insert has additional function.In case insert and tubular element be pressed into the groove interlock, user can be so that tubular element (comprising described well) rotates to required angle of penetration.In other words, insert not only is used for alignment, and it also can be used as the device that is used to adjust angle of penetration.
In certain embodiments, the present invention relates to a kind of fluid delivery system that is used to deliver the fluid to patient body.Described fluid delivery system comprises the outer housing with upper wall and lower wall, well equipment mechanism and penetrate tube, wherein said upper wall comprises upper opening and described lower wall comprises lower openings, described well equipment mechanism is set to and is arranged between outer housing inside and upper wall and the lower wall, and comprise the foraminous tubular element of tool, wherein said hole is set to and is arranged between described upper opening and the described lower openings, and the described tube that penetrates is used for the treatment of the conveying of fluid to patient body, wherein said penetrate tube be set to along with its by the insertion of upper opening and lower openings with the interlock of described hole.The treatment fluid is set to when penetrating tube with the interlock of described hole, delivers into by tubular element and penetrates tube, and enter in the patient body.
In certain embodiments, the present invention relates to a kind ofly be used to use fluid delivery system to deliver the fluid to the method for patient body.Described fluid delivery system comprises the outer housing with upper wall and lower wall, well equipment mechanism and penetrate tube, wherein said upper wall comprises upper opening and lower wall comprises lower openings, described well equipment mechanism is set to and is arranged between outer housing inside and upper wall and the lower wall, and comprise the foraminous tubular element of tool, wherein said hole is set to and is arranged between described upper opening and the described lower openings, and the described tube that penetrates is used for the treatment of the conveying of fluid to the patient body, wherein said penetrate tube be set to along with its by the insertion of upper opening and lower openings with the interlock of described hole.Said method comprising the steps of: will penetrate in the hole of fill-in well equipment mechanism up to described and penetrate tube and the interlock of described hole, and when described when penetrating tube, will treat FLUID TRANSPORTATION by described tubular element and enter and penetrate tin and enter in the patient body with described hole interlock.
The structure of the more feature and advantage of the present invention and each embodiment of the present invention at length discloses with operating in reference to the accompanying drawings.
Description of drawings
Present invention is described with reference to accompanying drawing.In the accompanying drawings, identical Reference numeral is represented identical or intimate element.In addition, in most of the cases, leftmost one digit number or long number are represented the accompanying drawing that described Reference numeral occurs first in the Reference numeral.
Fig. 1 is the exploded view according to the exemplary fluid conveyer device of some embodiments of the present invention;
Fig. 2 is the assembly drawing of the exemplary fluid conveyer device shown in Fig. 1;
Fig. 3 is another exploded view of the exemplary fluid conveyer device shown in Fig. 1;
Fig. 4 shows another assembly drawing of other details of the fluid delivery system shown in Fig. 1;
Fig. 5 shows the example well equipment mechanism according to the fluid delivery system of some embodiments of the present invention;
Fig. 6 shows the exemplary tube that penetrates according to well equipment mechanism some embodiments of the present invention, shown in Fig. 5;
Fig. 7 a is another view that penetrates tube shown in Fig. 6;
Fig. 7 b is the cutaway view according to the exemplary tubbiness spare of the well equipment mechanism of some embodiments of the present invention;
Fig. 7 c is the cutaway view that penetrates tube shown in Fig. 6;
Fig. 8 is the exploded view that penetrates tube shown in Fig. 6;
Fig. 9 is the exploded view that penetrates tube shown in the tubbiness spare shown in Fig. 7 b and Fig. 6;
Figure 10 according to some embodiments of the present invention, be inserted into tubbiness spare penetrate the tube cutaway view;
Figure 11 according to some embodiments of the present invention, be inserted in the tubbiness spare and penetrate the cutaway view that penetrates tube that member shifts out from penetrate tube;
Figure 12 is inserted in the tubbiness spare and penetrates another cutaway view that penetrates tube that member shifts out from penetrates tube;
The cutaway view that penetrates tube of the inclination of Figure 13 before according to some embodiments of the present invention, in the tubbiness spare of fill-in well equipment mechanism;
Figure 14 a-d is according to the cutaway view of the tubbiness spare of some embodiments of the present invention, well equipment mechanism;
Figure 15 is another cutaway view of the tubbiness spare shown in Figure 14 a-d;
Figure 16 shows according to exemplary fluid conveyer device some embodiments of the present invention, that be set to the pressure rotation that can realize tubbiness spare;
Figure 17 is another illustration of the exemplary fluid conveyer device shown in Figure 16;
Figure 18 is another illustration of the exemplary fluid conveyer device shown in Figure 16;
Figure 19 show according to some embodiments of the present invention, be set to the exemplary fluid conveyer device in the tubbiness spare that allows to penetrate the automatic fill-in well equipment mechanism of member;
Figure 20 is another illustration of the exemplary fluid conveyer device shown in Figure 19;
Figure 21 show according to some embodiments of the present invention, be set to and allow to penetrate member with the exemplary fluid conveyer device in the tubbiness spare of the automatic fill-in well equipment mechanism of required angle;
Figure 22 shows according to some embodiments of the present invention, shown in Figure 19 and be used for penetrating the exemplary fluid conveyer device that the device of the insertion of tube shifts out from the tubbiness spare of well equipment mechanism;
Figure 23 show according to some embodiments of the present invention, penetrate the exemplary fluid conveyer device that member shifts out the tube from penetrating of well equipment mechanism.
The specific embodiment
Fig. 1 shows the exploded view according to the exemplary fluid conveyer device 100 of some embodiments of the present invention.Fluid delivery system 100 comprises and is set to the module unit 110 and the distant control unit (not shown in figure 1) that can adhere on the patient body.Module unit 110 comprises single use portion 112, and it is connected with reusable part 114 separably.Some embodiment with described fluid delivery system of module unit are disclosed in total, common unsettled Israel patent application No.171813, and its whole contents is incorporated into this by reference.One of advantage of above-mentioned structure is to use the relatively costly parts of fluid delivery system in reusable part, and uses not too expensive component in single use portion.Simultaneously, described device cost in making, sell and using is lower.
Fig. 2 shows the assembly drawing according to the illustrated blocks unit 110 of the fluid delivery system 100 shown in Fig. 1 of some embodiments of the present invention.As shown in Figure 2, reusable part 114 is set to single use portion 112 and is connected.Single use portion 112 comprises aperture, top 116.The tubular element that aperture, top 116 is set to well equipment mechanism (not shown in Fig. 2) provides access.The well equipment mechanism is set to (not shown in Fig. 2, as still to discuss in conjunction with Fig. 5 below) between the upper wall and lower wall that is arranged in single use portion 112.
Fig. 3 and 4 shows other details of the module unit 110 shown in Fig. 1 and 2, comprises the parts that are arranged in reusable part 114 and single use portion 112.Module unit 110 comprises the tubular element 322 that is full of treatment fluidic liquid reservoir 318, carrier pipe 320 and is provided with the well equipment mechanism in hole 326.Carrier pipe 320 is set to liquid reservoir 318 and is connected with tubular element 322, so that their mutual fluids are communicated with.Module unit 110 can be set to and comprise and be used for pump that the treatment fluid is distributed to intubate (not shown at Fig. 3, but discuss in conjunction with Fig. 6 below) from liquid reservoir 318, and described intubate can be set to hypodermically and insert in the patient body.In certain embodiments, intubate can be set to be inserted in the tubular element 322, and be set to by hole 326 with by the suitable aperture, bottom in the lower wall that is arranged in single use portion 112 (not shown in Fig. 3 and 4, but discuss in conjunction with Fig. 5 below) and enter patient body hypodermically.
With reference to Fig. 4, carrier pipe 320 can be set between the roller of the swiveling wheel 424 that is placed on fixing head 428 and pump.The roller of pump is invisible in Fig. 4.Pump can be peristaltic pump or other suitable pumping mechanisms arbitrarily.In certain embodiments, can operate, can use spring 430 that fixing head 428 is pushed to roller in order to make module unit 110.By this method, when the wheel rotation, roller to fixing head 428 extruding, pushes carrier pipe 320 with carrier pipe 320 thus, and this can be called as the positive-displacement motion.Therefore, fluid by periodically from liquid reservoir 318 pumping enter carrier pipe 320, the stepping of going forward side by side goes into to be inserted hypodermically the intubate of patient body (not shown in Fig. 4).In some embodiments of the invention, single use portion 112 is set to holds the well equipment mechanism, and this will further describe.The well equipment mechanism can be set between the outlet 432 and intubate of carrier pipe 320.Because described well equipment mechanism makes carrier pipe 320 to be communicated with the intubate fluid, and can realize treating fluid from the supply of liquid reservoir 318 to patient body.
Fig. 4 also shows and passes hatching A-A and the B-B that tubular element 322 is drawn.The corresponding cross section A-A of module unit 110 and the details of B-B are illustrated in respectively among Fig. 5 and the 7a-c.
Fig. 5 shows according to the example well equipment mechanism 510 shown in the mode of the cutaway view of module unit 110 some embodiments of the present invention, that cut open with A-A along the line.Well equipment mechanism 510 comprises the tubular element 322 in the space in the single use portion 112 of being contained between the upper wall 534 of single use portion 112 and lower wall 536.In certain embodiments, tubular element 322 can be set to the tubbiness spare that is limited by cylindrical peripheral wall and two opposite butt ends (butt end).Only for convenience, tubular element 322 will be called as tubbiness spare 322.Tubbiness spare 322 has the center X-axis of portrait orientation.Extend in tubbiness spare 322 along the center Y-axis and perpendicular to X-axis in hole 326, as shown in Figure 5.Hole 326 can be set to and can enter by the aperture in the upper wall 534 116.The lower wall 536 of single use portion 112 comprises and 116 corresponding apertures 540, aperture.Aperture 540 is positioned at the position opposite with aperture 116, and aperture 116 and 540 combination are set to the inlet that the tubbiness spare 322 that passes in the well equipment mechanism 510 is provided and arrives patient skin.Aperture 116 and 540 size and dimension can be set to provides intubate that angle and/or position with any desired enter patient body and the insertion that penetrates member (discussing below).
Well equipment mechanism 510 also comprises two annular grooves 544,546 and corresponding sealing ring 548,550, and described sealing ring 548,550 is set to and is placed on respectively in the described annular groove 544,546.The tubbiness spare 322 of well equipment mechanism 510 also comprise be set to along X-axis from the hole 326 side paths 552 that extend to carrier pipe 320.Side path is provided with the inlet 554 at the junction point place that is disposed in carrier pipe 320 and tubbiness spare 322.Side path 552 also is set to the fluid that hole 326 is provided and enters the mouth between 554 and is communicated with.Because carrier pipe 320 is connected with inlet 554, so the treatment fluid can be transported to patient body by hole 326 from liquid reservoir 318.Tubbiness spare 322 comprises that also two are pressed into groove (indentation grooves) 556 and 558, and they can be disposed on the cylindrical peripheral wall (groove 556 and 558 will be described in more detail in conjunction with Figure 16-23 below) of tubbiness spare 322.
In certain embodiments, the size of tubbiness spare 322 and the layout between upper wall 534 and lower wall 536 thereof can realize that tubbiness spare 322 centers on rotatablely moving of its X-axis, shown in direction arrow 560.When tubbiness spare 322 during around the X-axis rotation, the orientation of Y-axis changes, and therefore, hole 326 is along with 322 rotations of tubbiness spare, and with respect to patient's skin tilt (suppose that before rotation Y-axis skin or any plane of reference with the patient basically is vertical).Those skilled in the art will appreciate that tubbiness spare 322 can rotate to any required angle.This allows intubate to insert in patient's the skin with the angle of penetration of any desired by hole 326.
Tubbiness spare 322 can be made by cheap material (for example plastics, polyethylene or other suitable material arbitrarily), described material can be designed as and is applicable to insulin or other treatment fluid arbitrarily, and can be set to fluid delivery system 100 is each use after, be dropped with the single use portion 112 of module unit 110.
Fig. 6 shows to be set to and is inserted in the tubbiness spare 332 and penetrates tube 662 in the patchhole 326 especially.Penetrate tube 662 and be set to disposablely, and can be dropped with single use portion 112.The described tube 662 that penetrates is set to along in the Y-axis insertion tubbiness spare 322, and described Y-axis is shown in Figure 5.
In certain embodiments, penetrate tube 662 comprise main part 664, the intubate 666 that is connected with main part 664 and have most advanced and sophisticated 686 penetrate member 668, tip 686 is suitable for thrusting patient's skin.Main part 664 can be set to and comprise long chamber 670 and short cavity 672.Long chamber 670 can be set to along main part 664 longitudinal extensions.Short cavity 672 can be set to and cross main part 664 horizontal expansions.Penetrate member 668 and can be inserted in the main part 664, and from main part 664, be moved out of by long chamber 670.
The external diameter in zone, upper and lower 674,676 can be selected by this way, promptly when penetrating tube 662 when being inserted in the hole 326, sealing ring 548, the 550 sealed body parts 664 in the tubbiness spare 322.In addition, the size of main part 664 can be thus set, and promptly in case penetrate tube 662 when being inserted in the tubbiness spare 322, short cavity 672 can be set to the side path 552 of tubbiness spare 322 and align.
Fig. 7 a and 7b are respectively the cutaway views that penetrates tube 662 and tubbiness spare 322.Fig. 7 b is the cutaway view along the intercepting of the profile direction B-B shown in Fig. 4.Fig. 7 b also shows the tubbiness spare 322 that is positioned at position of rotation, and tubbiness spare is (not shown in Fig. 7 b, still shown in Figure 5 around the X-axis rotation in described position; In Fig. 7 b, X-axis is vertical with the Z axle with Y-axis, and therefore, it is vertical with page place face).Fig. 7 b also shows the Y-axis with upper wall 534 and lower wall 536 vertical tubbiness spares.The inclination in case 322 rotations (no matter being to apply under the situation of power forcibly or not) of tubbiness spare, hole 326 promptly become, as shown in Fig. 7 b, therefore, Y direction changes.New Y direction is by dotted line Y
1-Y
1Illustrate.Line Y
1-Y
1Expression penetrates member 668 and is inserted into angle in the described skin 742 near patient's skin and intubate 666.
Fig. 7 a also comprises the hatching C-C that crosses zone line 678 draftings that penetrate tube 662.Fig. 7 c is the cutaway view of the tube 662 of C-C intercepting along the line.As from can seeing Fig. 7 c, the zone line 678 that penetrates tube 662 also comprises auxiliary short cavity 792.Auxiliary short cavity 792 can be set to vertical with short cavity 672, and can also be set to long chamber 670 fluids and be communicated with.Therefore, short cavity 672 and auxiliary short cavity 792 respectively along X-axis and Z spindle guide to, they are vertical with the Y-axis shown in the 7b with Fig. 5.Those skilled in the art will appreciate that in order to set up to be communicated with that additional short cavity and/or auxiliary short cavity can be arranged at and penetrate in the tube 662 with the fluid in long chamber 670.
Fig. 8-11 shows a plurality of views of the parts of the fluid delivery system 100 that is in different phase.Fig. 8 shows the exploded view that penetrates tube 662 according to some embodiments of the present invention.As shown in Figure 8, penetrate member 668 and be moved out of (that is to say, do not insert intubate 666) from main part 664.Therefore, before being used, penetrate member 668 and be set to by the eyelet in the lid 682 and insert in the main part 664 that penetrates tube 662 by patient (or medical worker).Those skilled in the art will appreciate that penetrating member 662 can be set to by patient, doctor or other medical worker arbitrarily, or the maker that penetrates tube 662 inserts.In addition, penetrate tube 662 can by cheap materials such as plastics, polyethylene or arbitrarily other suitable materials make.Like this, penetrating tube 662 can be dropped after fluid delivery system 100 each uses.
Fig. 9 shows and penetrates tube 662 assembly drawing, its have in main part of being inserted into 664 and place outer aperture 116 tops penetrate member 668, described outer aperture 116 is used for making and penetrates tube 662 patchholes 326.As shown in Figure 9, the lower wall 536 of single use portion 112 is set to contiguous patient's skin 742 placements.Figure 10 show in the hole 326 that is inserted into tubbiness spare 322 penetrate the tube 662.As shown in Figure 10, penetrating member 668 is inserted in a downward direction along main part 664.When penetrating member 668 when being inserted in the hole 326, intubate 666 is outstanding with the opening 540 that its sharp-pointed end 686 is set to from lower wall 536, and thrusts patient's skin 742.(as shown in Figure 10) in certain embodiments, the head 690 that penetrates member 668 is set to the top of the upper wall 534 that remains on single use portion 112, and therefore, can shift out from patient body in order to penetrate member 668, and it can be caught by the patient.As further illustrating among Figure 10, penetrate member 668 and be set to vertical with patient's skin 742.Those skilled in the art will appreciate that the angle of penetration that then penetrates 668 pairs of skins 742 of member will correspondingly change if tubbiness spare 322 rotates (shown in Fig. 5) around X-axis.
Figure 11 show when intubate 666 keeps being inserted in the skin 742, penetrate in the tube 662 penetrate that member 668 is moved out of penetrate tube 662.In certain embodiments, penetrate member 668 in order to shift out from skin 742, patient's (perhaps arbitrarily other medical worker) can catch head 690, and spurs it in the upward direction away from skin 742.Shift out penetrate member 668 after, penetrate tube 668 inside and continue immediately to keep and outside seal (and the influence that continues to keep not being subjected to outer member thus).This is owing to the existence of elastic packing plug 680.
In certain embodiments, because the diameter of zone line 678 is set to the diameter less than upper area 674 and lower area 676, so annular space 1194 can and penetrate between the zone line 678 of tube 662 at tubbiness spare 322.Described annular space 1194 can be set to by sealing ring 548,550 sealings.Annular space 1194 also is set to and is full of the treatment fluid, and described treatment fluid is set to by side path 552 and enters in the annular space 1194.Pump can be set to and make the treatment fluid be full of annular space 1194.Annular space 1194 can be manually, automatically, periodically or with any required time be filled at interval.As shown in Figure 11, annular space 1194 is set to long chamber 670 fluids and is communicated with.Such fluid is communicated with by short cavity 672,792 (not shown in Figure 11) to be realized.Therefore, the treatment fluid enters the intubate 666 by flow into long chamber 670 from annular space 1194.
Figure 12 is another cutaway view that penetrates tube 662 along B-B (as shown in Fig. 4 of front) intercepting.Penetrating tube 662 is shown as after it inserts in tubbiness spare 322.Annular space 1194 is shown as by short cavity 792 and is communicated with long chamber 670 fluids.
Figure 13 be near the opening 116 that is placed in the upper wall 534 of single use portion 112, be used for another view that penetrates tube 662 with angle [alpha] patchhole 326.Angle [alpha] centers on the X-axis rotation of described tubbiness spare by tubbiness spare 322 and forms, and is the angular displacement of Y-axis, and described Y-axis is passed hole 326 longitudinal extensions with respect to the surface of patient's skin 742.In order to penetrate in tube 662 patchholes 326, the described tube 662 that penetrates also tilts with identical angle [alpha], to align with hole 326.The rotation of tubbiness spare 322 and the example that penetrates tube 662 inclination are discussed with reference to Figure 16-18 below.
Figure 14-15 shows " float " exemplary embodiment of feature of well equipment mechanism.In some embodiments of the invention, term " floats " and means that upper wall 534 and lower wall 536 that tubbiness spare 322 can be set to respect to single use portion 112 can relatively move.In certain embodiments, tubbiness spare 322 and and the vertical wall of the contiguous single use portion 112 of tubbiness spare between be provided with the gap.
Figure 14 a-d shows the cutaway view of tubbiness spare 322.Especially, Figure 14 b is the cutaway view at the tubbiness spare 322 of the intercepting of the line B-B place shown in Figure 14 a.Figure 14 c is the cutaway view at the tubbiness spare 322 of the intercepting of the line C-C place shown in Figure 14 a.Figure 14 d is the cutaway view at the tubbiness spare 322 of the intercepting of the line X-X place shown in Figure 14 a.Figure 15 is the cutaway view at the tubbiness spare 322 of the intercepting of the line D-D place shown in Figure 14 a.
As shown in Figure 14 a-d, tubbiness spare 322 at one end has recess 1496, has circular projection 1498 at the other end.Single use portion 112 also comprises vertical wall 1402.Axle 1400 is set as and is placed between tubbiness spare 322 and the vertical wall 1402.One end of axle 1400 can be contained in the recess 1404 that is formed in the vertical wall 1402, and the other end of axle 1400 can be contained in the recess 1496. Recess 1404,1496 can be set to the form fit with axle 1400 respective end portions, thereby can realize the rotation of tubbiness spare 322 around its vertical X-axis.In certain embodiments, can have little gap between Zhou end and the corresponding recess 1404,1496.Described gap is set to realize that tubbiness spare 322 moves with respect to the linearity of its outer housing along X-axis and Z axle.
With reference to Figure 14 a-b and 15, tubbiness spare 322 is set to and comprises vertical partitions 1410.Separator 1410 can be set between the upper wall 534 and lower wall 536 of single use portion 112.Separator 1410 can also be set to vertical with vertical X-axis of tubbiness spare 322.In certain embodiments, separator 1410 has the width greater than the diameter of tubbiness spare 322.The width that those skilled in the art will appreciate that other also is feasible.Separator 1410 comprises opposite end 1412,1414. End 1412,1414 is set to by the corresponding alcove 1416,1418 that is arranged in the single use portion 112 and holds, as shown in Figure 14 d.End 1412,1414 is set to and is engaged in the alcove 1416,1418, so that corresponding gap 1420,1422 forms between end 1412,1414 and corresponding alcove 1416,1418.Described gap 1420,1422 is set to can realize separator 1410 moving relative to linear with respect to single use portion 112.
With reference to Figure 14 a-b, single use portion 112 also comprises the projection 1498 that is set in the opening that is received in the separator 1410.Described opening can be set to and described projection 1498 frictional fit, can realize that simultaneously the linearity of tubbiness spare 322 around the rotation of its vertical X-axis and separator 1410 along the Z axle moves.In certain embodiments, little gap 1424 can be arranged between tubbiness spare 322 and the separator 1410, thereby can realize tubbiness spare 322 and separator 1410 moving relative to linear along X-axis.
In certain embodiments, the combination of axle 1410 and projection 1498 can be set to the effect of playing sliding bearing, thereby can realize the rotation of tubbiness spare 322 around its vertical X-axis.This also allows patient (doctor or other medical worker) arbitrarily to adjust to penetrate member 668 (not shown in Figure 14 a-15) to thrust in the skin and intubate 666 can be inserted into angle in the patient body hypodermically.
In certain embodiments, gap 1506,1508,1420,1422 and 1424 can be set to and can realize tubbiness spare moving relative to vertical in horizontal plane.This can compensate and make that when the patient is worn over module unit on the his or her health inevitably moving of 666 pairs of outer housings of intubate is insensitive.In certain embodiments, fluid delivery system 100 can comprise and is set to the sealing ring 1426 that the sealing between carrier pipe 120 and the single use portion 112 is provided.
Figure 16-18 shows the exemplary embodiment that is set to the fluid delivery system of the pressure rotation that can realize tubbiness spare 322 according to of the present invention.In certain embodiments, in order to make 322 rotations of tubbiness spare, use special-purpose the Shear tool 1628.Instrument 1628 is set to and 322 interlocks of tubbiness spare, as shown in Figure 16.As shown in figure 16, special-purpose the Shear tool 1628 can be set to handle, and can be by aperture, top 116 (shown in Figure 17) and the interlock of tubbiness spare.In such embodiments, instrument 1628 can be caught by patient (doctor or other medical worker) arbitrarily, and rotates to required angle along arrow 1630 forcibly.Required angle has determined to penetrate tube 662 angles that will thrust patient's skin.
With reference to Figure 17, the Shear tool 1628 comprises can be set to the lower end 1732 that comprises projection 1734 (shown in Figure 17) and 1836 (shown in Figure 18). Projection 1734 and 1836 is set to away from the bottom surface of lower end 1732 extends.Projection 1734 and 1836 is set to provides the reliable interlock of the Shear tool 1628 with tubbiness spare 322.In certain embodiments, the shape that is set to the end face of tubbiness spare 322 of the bottom surface of lower end 1732 is complementary.Projection 1734,1836 is set to and is engaged in (shown in Figure 5 before) in the groove 556,558 respectively.Therefore, in order to adjust the angle of tubbiness spare 322, patient (doctor or other medical worker) is by aperture 116 insertion instruments 1628, and projection 1734,1836 and corresponding grooves 556,558 are closely cooperated, in case instrument 1628 and 322 interlocks of tubbiness spare, patient (doctor or other medical worker) just makes tubbiness spare rotate to required angle.After tubbiness spare 322 was adjusted to required angle of penetration, instrument 1628 was moved out of, and penetrated tube and 662 be inserted into
(as top discuss with reference to Fig. 1-13).It will be appreciated by those skilled in the art that, the insertion of instrument 1628, rotate and shift out and penetrate tube 662 insertion and shift out and can manually or automatically finish, and its can also by patient, doctor, other the medical worker or arbitrarily other titular individuals carry out.
Figure 19-23 shows according to pressure rotation of the present invention, as can to realize tubbiness spare 322 and penetrates tube 662 exemplary embodiments that enter the fluid delivery system of the automatic insertion in the tubbiness spare 322.Shown in Figure 19-23, can be set to pressure rotation that tubbiness spare 322 is provided and the automatic insertion that penetrates tube 662 with penetrating 662 " insert " instrument 1915 that are included in wherein.In certain embodiments, insert instrument 1915 be set to top with reference to Figure 16-18 content of being discussed similar mode and 322 interlocks of tubbiness spare.
As mentioned above, Figure 19 show when insert 1915 in its outer housing 1938 by preloaded to penetrate tube 662 and actuation spring 1940 biased so that penetrate the situation of tube 662 when being positioned at its retracted position above the tubbiness spare 322.In certain embodiments, to the patient, module unit 110 is adhered on patient's the skin 742 in the treatment FLUID TRANSPORTATION, and the lower end 1942 of " insert " instrument 1915 is (similar to the method for discussion among Figure 16-18 to 322 interlocks of tubbiness spare.Those skilled in the art will appreciate that it also is feasible making the other types of described instrument and 322 interlocks of tubbiness spare).As shown in Figure 19, insert instrument 1915 does not tilt as yet, and similarly, tubbiness spare 322 does not also rotate by instrument 1915 forcibly.In certain embodiments, the initial angle (before the rotation) of instrument 1915 and 322 interlocks of tubbiness spare approximately is 90 degree with respect to the top surface of module unit 110 (or skin 742, or other surface) arbitrarily.Those skilled in the art will appreciate that it is feasible making instrument 1915 and other angles of tubbiness spare 322 interlocks.Insert instrument 1915 also can comprise being set to make and penetrates tube 662 and remain on safe locking mechanism 1944 in the retracted position of outer housing 1938 inside of instrument 1915.In case actuator 1942 is released and safe locking mechanism 1944 is separated, penetrates tube and 662 promptly be released and be advanced in the tubbiness spare 322, and utilize and penetrate member 668 and thrust in patient's the skin 742 (as shown in Figure 20) by spring 1940.
Figure 21 shows insert instrument 1915 and is tilted (similar to the method for being discussed among Figure 16-18) situation to required angle.In case insert instrument 1915 is tilted, penetrate tube 662 promptly to be released to mode similar shown in Figure 19-20.
Figure 22-23 shows the insert instrument 1915 that is moved out of (or separation) from tubbiness spare 322 and module unit 110.In certain embodiments, in case instrument 1915 can be set to and penetrate tube and 662 be inserted in the tubbiness spare 322, penetrate tube 668 and thrust in patient's the skin 742 and intubate 666 is inserted in the patient body (as shown in Figure 22), described instrument 1915 promptly is moved out of.In case described instrument 1915 is moved out of, penetrates member 668 and promptly can under the situation that does not shift out intubate 666, from penetrate tube 662, shift out (as shown in Figure 23).Those skilled in the art will appreciate that the angle that intubate 666 can be set to any desired is inserted into.Treat fluid then and be supplied to patient body hypodermically by intubate 666, described intubate 666 is communicated with carrier pipe 320 fluids by tubbiness spare 322.
Those skilled in the art will appreciate that insert instrument 1915, penetrate tube 662, penetrate member 668 and can be set to and manually or automatically shifted out.In certain embodiments, spring can be set, thus can implementation tool 1915 and the separating of tubbiness spare 322.
The exemplary embodiment of method of the present invention and parts here is described.Mention as other places, these exemplary embodiments are only described for illustrative purposes, and unrestriction.Other embodiment is feasible, and is covered by the present invention.Based in the instruction that this comprised, such embodiment is conspicuous for those skilled in the relevant art.Therefore, range of the present invention and scope should be by above-mentioned exemplary embodiment restrictions arbitrarily, and should be only limit according to following claim book and the description that is equal to thereof.
Claims (31)
1. fluid delivery system that is used to deliver the fluid to patient body comprises:
Have the upper wall that limits opening and the outer housing of lower wall;
Well equipment mechanism, described well equipment mechanism are set to and are arranged between described outer housing inner and described upper wall and the described lower wall, and comprise that the foraminous tubular element of tool, wherein said hole are set to and be arranged in the described opening; With
Be used for the treatment of the penetrate tube of fluid to the conveying of patient body, wherein said penetrate tube be set to along with its by the insertion of described opening with the interlock of described hole;
Wherein, the treatment fluid is set to when described delivering into by described tubular element when penetrating tube with described hole interlock and describedly penetrates tube and enter in the patient body.
2. fluid delivery system as claimed in claim 1 is characterized in that, also comprises:
Single use portion, it is set to and comprises:
The fluidic liquid reservoir of treatment is housed; With
With the joining carrier pipe of described liquid reservoir, wherein said carrier pipe is set to described
The described tubular element of well equipment mechanism links; With
Be set to the pump that the treatment fluid is pumped into described carrier pipe from described liquid reservoir.
3. fluid delivery system as claimed in claim 2 is characterized in that, described single use portion also comprises described well equipment mechanism.
4. fluid delivery system as claimed in claim 1 is characterized in that, described tubular element comprises being set to provides the side path of treatment fluid to the conveying in the described hole of described tubular element.
5. fluid delivery system as claimed in claim 1 is characterized in that described tubular element is set to around at least one rotation.
6. fluid delivery system as claimed in claim 1 is characterized in that described hole is set to around at least one rotation.
7. fluid delivery system as claimed in claim 1 is characterized in that, the described tube that penetrates also comprises:
Main part, it has:
Be set to long chamber along described main part longitudinal extension;
At least one is set to crosses described main part horizontal expansion and is set to the short cavity that is communicated with described long chamber fluid;
Wherein, described long chamber and described short cavity also are set to when the described tube that penetrates and are communicated with the described tubular element fluid of described well equipment mechanism when being inserted in the described hole;
Be set to the intubate that is connected with described main part;
Be set to the member that penetrates that inserts in described long chamber and the described intubate, the wherein said member that penetrates also is set in the skin that thrusts the patient.
8. fluid delivery system as claimed in claim 7 is characterized in that, the described member that penetrates is set to and can shifts out from described intubate.
9. fluid delivery system as claimed in claim 7 is characterized in that, described long chamber is set to vertical mutually basically with described short cavity.
10. fluid delivery system as claimed in claim 7 is characterized in that, described long chamber comprises sealing-plug, and the described member that penetrates is set to when described penetrating and thrusts in the described sealing-plug when member is inserted in the described long chamber; And wherein said sealing-plug is set to when described penetrating and seals described long chamber when member is inserted in the described long chamber.
11. fluid delivery system as claimed in claim 7 is characterized in that, the described member that penetrates comprises and is set to the pin that thrusts in the patient skin.
12. fluid delivery system as claimed in claim 7 is characterized in that, the described tube that penetrates is set to certain angle and inserts in the described hole.
13. fluid delivery system as claimed in claim 12 is characterized in that, described intubate is set to described angle will treat FLUID TRANSPORTATION to patient body.
14. fluid delivery system as claimed in claim 7 is characterized in that, described opening is set to when the described tube that penetrates and is adapted to described hole when being inserted in the described hole and describedly penetrates rotatablely moving of tube.
15. fluid delivery system as claimed in claim 1 is characterized in that, the described tube that penetrates is set to and manually inserts in the described hole.
16. fluid delivery system as claimed in claim 1 is characterized in that, the described tube that penetrates is set to and automatically inserts in the described hole.
17. fluid delivery system as claimed in claim 1 is characterized in that, also comprises being set to described penetrating the Shear tool that tube makes the rotation of described hole before inserting in the described hole.
18. fluid delivery system as claimed in claim 1, it is characterized in that, also comprise the insert instrument, it is set to the described tube that penetrates is fixed in the outer housing of described insert instrument, and wherein said insert instrument is set at the described tube that penetrates and makes the rotation of described hole before inserting in the described hole; And in case described hole rotates to required angle, described insert instrument is set to the described tube that penetrates is inserted in the described hole.
19. fluid delivery system as claimed in claim 18 is characterized in that, described insert instrument is set to the described tube that penetrates is manually inserted in the described hole.
20. fluid delivery system as claimed in claim 18 is characterized in that, described insert instrument is set to the described tube that penetrates is automatically inserted in the described hole.
21. fluid delivery system as claimed in claim 1 is characterized in that, described fluid delivery system is constructed to module unit.
22. fluid delivery system as claimed in claim 1 is characterized in that, the treatment fluid is carried hypodermically.
23. fluid delivery system as claimed in claim 1 is characterized in that, the treatment fluid is an insulin.
24. fluid delivery system as claimed in claim 1 is characterized in that, at least a portion of described single use portion is by the plastics manufacturing.
25. one kind is used to use fluid delivery system to deliver the fluid to the method for patient body, described fluid delivery system has:
Have the upper wall that limits opening and the outer housing of lower wall;
Be set to and be arranged between described outer housing inside and described upper wall and the described lower wall and bag
Draw together the well equipment mechanism of the foraminous tubular element of tool, wherein said hole is set to and is arranged in
In the described opening; With
Be used for the treatment of the penetrate tube of fluid to the conveying of patient body, wherein said penetrate tube be set to along with its by the insertion of described opening with the interlock of described hole;
Said method comprising the steps of:
To penetrate in the described hole of a fill-in well equipment mechanism, up to described penetrate the tube with the interlock of described hole; With
By described tubular element delivering therapeutic fluid enter penetrate the tube and enter in the patient body.
26. method as claimed in claim 25 is characterized in that, described inserting step also comprises in the skin that thrusts the patient.
27. method as claimed in claim 25 is characterized in that, also comprises:
Penetrating before tube is inserted into required angle, make the described hole rotation of well equipment mechanism;
To penetrate tube and insert in the described hole, up to penetrating tube and the interlock of described hole; With
By described tubular element delivering therapeutic fluid enter penetrate the tube and enter in the patient body.
28. one kind is used for the fluid delivery system of treatment FLUID TRANSPORTATION to patient body comprised:
The module unit that comprises single use portion and reusable part;
Comprise the described single use portion that is arranged at the well device between the first wall and second wall;
By at least one first aperture that limits in described first wall and described second wall;
Wherein, described well device is set to and comprises:
The foraminous tubular element of tool;
Inlet;
The carrier pipe that is communicated with described inlet fluid; With
Side path between described inlet and described hole.
29. fluid delivery system as claimed in claim 28 is characterized in that, described tubular element is set to rotation, so that described hole can be positioned a plurality of positions with respect to described first and/or second wall.
30. fluid delivery system as claimed in claim 29, it is characterized in that, also comprise and penetrate tube, the described tube that penetrates comprises main part, intubate and is set to the member that penetrates that thrusts in the patient skin, and wherein said main part comprises and is used to second chamber that receives fluidic first chamber and be communicated with described intubate and described first chamber.
31. one kind is used for the fluid delivery system of treatment FLUID TRANSPORTATION to patient body comprised:
Fluid delivery system with module unit, described module unit comprise single use portion and reusable part, and wherein said single use portion comprises:
First wall with first aperture;
Second wall with second aperture;
Fluid delivery tube; With
Well device between described first wall and described second wall;
Wherein said well equipment mechanism comprises:
The foraminous tubular element of tool;
The inlet that is communicated with described carrier pipe fluid and
Side path between described inlet and described hole, wherein said tubular element is set to rotation, so that first and/or second wall that described hole can be set to respect to described single use portion is positioned a plurality of positions; With
Be set to the tube that penetrates in the described hole that can be received in described tubular element; The wherein said tube that penetrates comprises:
Intubate;
Main part; With
Be suitable for thrusting the member that penetrates in the described patient skin;
Wherein said main part comprises:
Be used to receive fluidic first chamber; With
Second chamber that is communicated with described intubate and described first chamber.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83311006P | 2006-07-24 | 2006-07-24 | |
| US60/833,110 | 2006-07-24 | ||
| US83787706P | 2006-08-14 | 2006-08-14 | |
| US60/837,877 | 2006-08-14 | ||
| PCT/IL2007/000932 WO2008012817A1 (en) | 2006-07-24 | 2007-07-24 | Systems, devices and methods for fluid/drug delivery |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210352811.9A Division CN102921062B (en) | 2006-07-24 | 2007-07-24 | Devices for fluid/drug delivery |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101522234A true CN101522234A (en) | 2009-09-02 |
| CN101522234B CN101522234B (en) | 2012-11-14 |
Family
ID=41082336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007800339432A Expired - Fee Related CN101522234B (en) | 2006-07-24 | 2007-07-24 | Systems, devices and methods for fluid/drug delivery |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP2009544398A (en) |
| CN (1) | CN101522234B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013070715A (en) * | 2011-09-26 | 2013-04-22 | Terumo Corp | Liquid-drug administration device |
| US10232155B2 (en) * | 2012-11-26 | 2019-03-19 | Kci Licensing, Inc. | Combined solution pump and storage system for use with a reduced-pressure treatment system |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1283827C (en) * | 1986-12-18 | 1991-05-07 | Giorgio Cirelli | Appliance for injection of liquid formulations |
| US5957895A (en) * | 1998-02-20 | 1999-09-28 | Becton Dickinson And Company | Low-profile automatic injection device with self-emptying reservoir |
-
2007
- 2007-07-24 CN CN2007800339432A patent/CN101522234B/en not_active Expired - Fee Related
- 2007-07-24 JP JP2009521416A patent/JP2009544398A/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN101522234B (en) | 2012-11-14 |
| JP2009544398A (en) | 2009-12-17 |
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