CN101518673A - Light power reaction device - Google Patents
Light power reaction device Download PDFInfo
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- CN101518673A CN101518673A CN200910106200A CN200910106200A CN101518673A CN 101518673 A CN101518673 A CN 101518673A CN 200910106200 A CN200910106200 A CN 200910106200A CN 200910106200 A CN200910106200 A CN 200910106200A CN 101518673 A CN101518673 A CN 101518673A
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Abstract
The invention discloses a light power reaction device which comprises a box body, a light source module, a lifting platform, a light source drive circuit and a control circuit, wherein the box body is made of light-tight materials, the light source module is fixed below the top of the box body and comprises a light source formed by a plurality of LED lamps, and the lifting platform is arranged above the bottom of the box body, used for placing reactants and connected to the bottom of the box body through a lifting regulating component; the light source drive circuit is electrically connected with the light source module and used for providing power supply for driving the light source module, the light source drive circuit regulates the light power of the light source module by regulating current, and the control circuit is electrically connected with the light source drive circuit and used for controlling the lighting time of the light source module. The invention provides the light power reaction device for light power, which can not be interrupted by external lighting, is convenient to precisely control the amount of light power and the lighting time and has uniform light dose everywhere within a lighting range.
Description
Technical field
The present invention relates to optoelectronic areas, relate in particular to a kind of light power reaction device.
Background technology
Photodynamic therapy (Photodynamic Therapy, PDT) former title photoradiation therapy, photochemotherapy, be utilize specific wavelength rayed on certain photoactive substance, produce a kind of method of reaction such as a series of chemistry, physics, biology then with treatment malignant tumor and various benign diseases.The factor that influences PDT mainly contains photosensitizer, light source and tissue oxygen concentration.In photodynamic therapy, the photosensitizer that uses only is being subjected under the irradiation of special wavelength light, the ability resonant excitation forms the photosensitizer of excited state, promptly with the monochromatic light of doses excite in the inducing cell the photoproduction reaction---the sensitiser absorption light energy is excited, form the excited triplet state photosensitizer.These excited state triplet state photosensitizer are by with tissue substrate or hydrogen atom or electron interaction or directly energy is shifted oxygen supply, produce some oxygen activity molecules (Radical Oxygen Species, ROS), ROS comes the attack cells structure by Oxidation, this damage may be cell membrane or proteic oxidative damage, when the accumulation of oxidative damage surpassed certain threshold value, cell just began death.Yet there is certain dependence in irradiation generates oxide and singlet oxygen in the light dosage pair cell of cell amount, the decrease in efficiency of exposure light dosage too little meeting causing PDT, and light dosage can not be ignored again normal cells injury too greatly.Therefore, the optical wavelength that light source sends, luminous power size and illumination mode etc. all affects cell or the biological tissue photodynamic effect under illumination, thereby influences the effect of photodynamic therapy.Simultaneously, for same group of experiment remained under the identical experiment condition, each position of hot spot should keep identical luminous power, it is the uniformity of hot spot, so the area of the hot spot that light source sends and the luminous power uniformity, influence also can not be ignored with experimental data to the carrying out of the experiment of probing into photodynamic reaction.
At present, it generally is to carry out the photoproduction reaction at 96 well culture plates that the cell of photodynamic therapy is accepted the illumination experiment, and extensively the light source that adopts is a LASER Light Source, and the control of light dosage is generally artificial control light source pair cell irradiation a period of time, irradiation a period of time not then, so repeatedly.
The inventor is in realizing process of the present invention, finding to have now the PDT cell accepts in the illumination experiment, photodynamic reaction is subjected to the interference (as natural light or laboratory illumination light) of external environment illumination easily, simultaneously to the difficult accurately control of the light dosage of photodynamic reaction, irradiated area, thereby influence the effect of photoreaction.
Summary of the invention
The embodiment of the invention provides a kind of light power reaction device, so that a PDT reaction unit simple and easy, that reaction condition well and not is subject to external environmental interference to be provided.
For addressing the above problem, the embodiment of the invention provides a kind of light power reaction device, comprising:
Casing, this casing is made by light-proof material;
Be fixed in the light source module of below, described casing top, this light source module comprises the light source of being made up of a plurality of LED lamps;
Be arranged at the hoistable platform that is used for the placing response thing of described box bottom top, this hoistable platform is connected with described box bottom by the lift adjustment parts;
Light source driving circuit is electrically connected on described light source module, for described light source module provides power drives,, and the luminous power by the described light source module of regulating circuit Current Regulation;
Control circuit is electrically connected on described light source driving circuit, is used to control the light application time of described light source module.
A kind of apparatus for photoreaction that the embodiment of the invention provides, the casing of making by light-proof material, be fixed in the light source module of below, described casing top, be arranged at described box bottom top be used for placing response thing and conditioned reaction thing and space between light sources from hoistable platform, be electrically connected and described light source module, for described light source module provides power drives, and the light source driving circuit of the luminous power of the described light source module of scalable, and be electrically connected on described light source driving circuit, be used to control the control circuit of the light application time of described light source module, constituted one simple and easy, be not subjected to ambient light according to disturbing, be convenient to accurately control the light power reaction device of luminous power size and light application time.
Description of drawings
In order to be illustrated more clearly in the embodiment of the invention or technical scheme of the prior art, to do to introduce simply to the accompanying drawing of required use in embodiment or the description of the Prior Art below, apparently, accompanying drawing in describing below only is some embodiments of the present invention, for those of ordinary skills, under the prerequisite of not paying creative work, can also obtain other accompanying drawing according to these accompanying drawings.
Fig. 1 is the composition sketch map of a kind of light power reaction device of the embodiment of the invention;
Fig. 2 is the schematic diagram of light source driving circuit in a kind of light power reaction device of the embodiment of the invention;
Fig. 3 is the schematic diagram of control circuit in a kind of light power reaction device of the embodiment of the invention;
Fig. 4 is the schematic diagram of power circuit in a kind of light power reaction device of the embodiment of the invention.
The specific embodiment
Below in conjunction with the accompanying drawing in the embodiment of the invention, the technical scheme in the embodiment of the invention is clearly and completely described, obviously, described embodiment only is the present invention's part embodiment, rather than whole embodiment.Based on the embodiment among the present invention, those of ordinary skills belong to the scope of protection of the invention not making the every other embodiment that is obtained under the creative work prerequisite.
Fig. 1 is the composition sketch map of a kind of light power reaction device of the embodiment of the invention.This device mainly comprises casing 10, light source module 11, fin 12, optically focused parts 13, hoistable platform 14, lift adjustment parts 15, light source driving circuit, control circuit and power supply 18, in order to make technical solution of the present invention clear more complete, below will to each component function and between relation be described in detail.
Casing 10, described casing is made by light-proof material, forms " darkroom " of a photoreaction, prevents the interference of extraneous light (as natural light or laboratory illuminating ray) light reflex, and can protect corresponding circuit.
Light source module 11, be fixed in below, described casing 10 tops, this light source module 11 comprises the light source of being made up of a plurality of LED (Light Emitting Diode, light emitting diode) lamp, described led light source is a high-power LED light source, because high-power LED light source heat effect is very little.Great power LED is divided into LED such as astigmatism, optically focused, wine glass-shaped by the top light emitting lens, in order to obtain luminous power hot spot relatively uniformly, this device is selected scattered-light LED for use.Great power LED has redness, yellow, yellow green, green, blueness, white etc. by the color branch, when specifically implementing, can obtain different optical source wavelengths according to the LED lamp that the experiment demand is provided with different colours.In addition, LED is lined up annular or circle and can further improve the hot spot uniformity.
Optically focused parts 13 are arranged under the described light source module, are used to regulate the spot size of the scattered light that described light source module sends.During specific implementation, described optically focused parts 13 can be the optically focused light tube of adjustable-length, described optically focused light tube is made up of two different cylinder sockets of diameter, regulate the total length of optically focused light tube by the coincidence length of regulating two cylinders, for example, use the optically focused light tube of diameter, regulate the length of optically focused light tube as 8cm, the scattered light that light source can be sent is limited in the circular area scope that diameter is 8cm, obtain one everywhere the luminous power size differ and be no more than 5% uniform light spots.
Hoistable platform 14 is arranged at top, described casing 10 bottoms and is used for the placing response thing, and this hoistable platform is connected with described box bottom by lift adjustment parts 15, by regulating the distance between described lift adjustment parts 15 scalable reactants and the light source module.During specific implementation, by the length of the described optically focused light of fit adjustment tube and the distance between described lift adjustment parts change light source and the cell, thereby the luminous power size that the scalable reactant receives, and regulate the light source light scattering and be mapped to spot size on the cell, make the luminous power of each position of reactant be consistent substantially.
The light source driving circuit (not shown) is electrically connected on described light source module, for described light source module 11 provides power drives, and the luminous power by the described light source module of regulating circuit electric current scalable.Described light source driving circuit comprises that an adjustable resistance drives chip with the LED that links to each other with described adjustable resistance, the outfan that described LED drives chip links to each other with described light source module, by regulating the electric current that described adjustable resistance changes circuit, thereby reach the purpose of the luminous power of regulating the light source module; Described LED constant-flow driver comprises the Enable Pin that links to each other with the outfan of control circuit, whether controls described light source driving circuit work by described Enable Pin control circuit according to default light application time, thereby controls the light application time of described light source module.During specific implementation, with reference to figure 2, Fig. 2 is the schematic diagram of light source driving circuit in a kind of light power reaction device of the embodiment of the invention.
It is the DD311 chip that LED drives chip, built-in current mirror and current switch mechanism, and DD311 can drive the output current up to 1 ampere, and can see through output current is set in adjustment arbitrarily with reference to input current (IREF) size.Output current value is about 100 times IREF, and IREF can set by regulating plug-in adjustable resistance or bias voltage.Fine setting adjustable resistance or change bias voltage size can realize that overall brightness is adjusted simultaneously between single LEDs gamma correction or plurality of LEDs.
The voltage that the outfan of chip can bear is up to 33V, supports the serial connection of many great power LEDs to use, and has output enable end (Enable) and can realize controlling lighting of LED and extinguish.Adjustable resistance R in the regulating circuit, scalable input current, thereby the power of adjustable light sources.When power circuit provided the bias voltage of 12V, the maximum value of adjustable resistance was 5K or 10K, and output current is 1A to the maximum, and the operating current of great power LED is approximately 330mA, and if therefore enough driving LED when needing several LED, only need get final product the LED series connection.
The control circuit (not shown) is electrically connected on described light source driving circuit, whether is used to control described light source driving circuit work, thereby controls the light application time of described light source module.During specific implementation, with reference to figure 3, Fig. 3 is the schematic diagram of control circuit in a kind of light power reaction device of the embodiment of the invention.Described control circuit by programming the single-chip microcomputer 89S52 and the correspondent peripheral circuit of program form, single-chip microcomputer has 32 I/O mouths, P1, P2, P3, P4, the keyboard that the design selects for use the P2 mouth to be connected into 4 * 4, the P1.0 mouth is exported high and low level.4 * 4 keyboard has 16 keys, the meaning of this 16 keys representative as shown in Table 1:
Table one:
| 0 | 4 | 8 | ON |
| 1 | 5 | 9 | The input |
| 2 | 6 | 10 | The input |
| 3 | 7 | 20 | Zero clearing |
The port P1.0 of control circuit output high-low level is connected together with Enable Pin the 5th foot of above-mentioned LED driving chip DD311, and the voltage of the 5th foot is during more than or equal to 3.3 volts, chip operation, and during less than 3.3 volts, chip is not worked.The high voltage of single-chip microcomputer output is approximately 4.9 volts, and low-voltage is approximately zero volt.During the experiment beginning, energized is pressed the button ON on the circuit board, control circuit output high level, and light source driving circuit is started working, and light source led is lighted; In addition, press the reset key OFF key on the circuit board, the control circuit output low level, light source driving circuit quits work, and LED extinguishes.
If will import the control time, press this key of zero clearing earlier, when guaranteeing that program begins to carry out, want input high level during the time, click this key of input high level time earlier, and then according to requirement of experiment, the input value corresponding such as input 21 minutes, is then successively pressed 20 and 1 these two keys; In like manner, input low level during the time, click this key of input low level time earlier, and then input value corresponding, such as 15 minutes, then successively press 10 and 5 these two keys, then circuit can repeatedly be exported the high-low level of identical time according to the time of the high-low level of importing.If will revise high-low level time, then to press earlier reset key, and then key in the high-low level value, operation is as previously described.Control the light application time of photodynamic reaction by single-chip microcomputer, not needing the people is timing, and easy to operate and time control accurately.
Power supply 18 is used to described light source driving circuit, control circuit that stable direct-current working volts are provided.Fig. 4 is the power circuit principle figure of a kind of light power reaction device of providing of the embodiment of the invention, described power circuit is formed by connecting by transformator, the rectification of bridge heap, electric capacity and voltage stabilizing chip, change High Level AC Voltage into galvanic current, for described light source driving circuit and control circuit provide stable direct-current working volts.
In sum, a kind of light power reaction device that the embodiment of the invention provides, in the casing of making by light-proof material, height and optically focused parts by the fit adjustment hoistable platform, regulate the distance between photoreaction thing and the light source, thereby the luminous power that the scalable reactant receives size and facula area size, realize accurately control light application time and illumination power by control circuit and light source driving circuit simultaneously, and can obtain different optical source wavelengths according to the high-powered LED lamp that the experiment demand is provided with different colours, therefore, the embodiment of the invention provides one not to be subjected to ambient light according to disturbing, be convenient to the selective light source wavelength, and be convenient to accurately control light application time, illumination power and in illumination range the uniform light power reaction device of light dosage everywhere.
Above disclosed is a kind of preferred embodiment of the present invention only, can not limit the present invention's interest field certainly with this, and therefore the equivalent variations of doing according to claim of the present invention still belongs to the scope that the present invention is contained.
Claims (7)
1, a kind of light power reaction device is characterized in that, comprising:
Casing, this casing is made by light-proof material;
Be fixed in the light source module of below, described casing top, this light source module comprises the light source of being made up of a plurality of LED lamps;
Be arranged at the hoistable platform that is used for the placing response thing of described box bottom top, this hoistable platform is connected with described box bottom by the lift adjustment parts;
Light source driving circuit is electrically connected on described light source module, for described light source module provides power drives, and the luminous power by the described light source module of regulating circuit Current Regulation;
Control circuit is electrically connected on described light source driving circuit, is used to control the light application time of described light source module.
2, device as claimed in claim 1 is characterized in that, described device also comprises the optically focused parts that are arranged under the described light source module, is used to regulate the spot size of the scattered light that described light source module sends.
3, device as claimed in claim 2 is characterized in that, the optically focused light tube that described optically focused parts are adjustable-length.
4, device as claimed in claim 1, it is characterized in that, described light source driving circuit comprises that an adjustable resistance drives chip with the LED that links to each other with described adjustable resistance, the outfan that described LED drives chip links to each other with described light source module, regulates the luminous power of light source module by regulating described adjustable resistance; Described LED drives chip and comprises the Enable Pin that links to each other with the outfan of control circuit, and by described Enable Pin, control circuit is controlled described light source driving circuit according to default light application time and driven described light source module.
5, device as claimed in claim 1 is characterized in that, the led light source in the described light source module is a high-power LED light source.
6, device as claimed in claim 5 is characterized in that, described casing top is provided with at least one fin, and the led light source in the described light source module sticks on the described fin.
7, as any described device of claim 1 to 6, it is characterized in that described device also comprises power supply, be used to described light source driving circuit, control circuit, working power is provided.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910106200A CN101518673A (en) | 2009-03-27 | 2009-03-27 | Light power reaction device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910106200A CN101518673A (en) | 2009-03-27 | 2009-03-27 | Light power reaction device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101518673A true CN101518673A (en) | 2009-09-02 |
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ID=41079598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910106200A Pending CN101518673A (en) | 2009-03-27 | 2009-03-27 | Light power reaction device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101518673A (en) |
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2009
- 2009-03-27 CN CN200910106200A patent/CN101518673A/en active Pending
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Open date: 20090902 |