CN101505676A - Pharmacological, chemical, and topical agent enhancement apparatus and method for using same - Google Patents

Abstract

A method for enhancing pharmacological, chemical, topical, and cosmetic effects comprising applying at least one reactive agent to a target pathway structure (step 101); configuring at least one waveform having at least one waveform parameter (step 102); selecting a value of said at least one waveform parameter of said at least one waveform to maximize at least one of a signal to noise ratio and a Power signal to noise ratio (step 103); in a target pathway structure, using said at least one waveform that maximizes said at least one of a signal to noise ratio and a Power signal to noise ratio in a target pathway structure to which said reactive agent has been applied, to generate an electromagnetic signal (step 104); and coupling said electromagnetic signal to said target pathway structure to modulate said target pathway structure (step 105).

Description

Medicament, chemical agent and local agent enhancement apparatus and using method thereof

Technical field

The interaction that the present invention relates to the electromagnetic environment by change and living tissue, cell and molecule strengthens the effectiveness of the medicament, chemical agent, enamel and the local agent that are used to handle living tissue, cell and molecule.The invention still further relates to the method that should be used for regulating cell and tissue growth, reparation, maintenance and general behavior by the coding electromagnetic information.Especially, the present invention comes to provide to one or more body parts the application of very specific electromagnetic frequency (EMF) signal pattern by the active coupling of the surgery noinvasive of coding electromagnetic information.Can be used for strengthening the various effectiveness of such agent with the application of the bonded such electromagnetic waveforms of the medicament, chemical agent, enamel and the local agent that are applied to people, animal and plant target pathway structure (for example cell, organ, tissue and molecule).

Background technology

The use of most of low frequency EMF combines with the application of bone repair and healing.Like this, the current orthopedic clinical use of EMF waveform and EMF waveform comprises relative low frequency component and very low power is arranged, and causes the maximum field in every centimetre one microvolt (mv/cm) scope at the frequency place that is lower than 5KHz.The linear physico-chemical process of scope of EMF waveform patterns that uses the electrochemistry model of cell membrane to predict can to expect biological effect is based on following hypothesis: cell membrane, particularly be combined in the cell membrane or on the ion of structure be possible EMF target.Therefore, must determine the scope of waveform parameter, for this waveform parameter, induction field can electrochemically be coupled at cell surface for example by using the kinetics that relies on voltage.The expansion of this linear model comprises Lorentz (Lorentz) power Consideration, and its magnetic component that has finally confirmed EMF can play an important role in the EMF treatment.This causes in very low frequency range from the AC of merging and the ion cyclotron resonance and the quantum model of DC magnetic field effect prediction interests.

Continuous sinusoidal wave pulse radiation frequency (PRF) signal that produces by the 27.12MHz that is used for the deep tissues healing is known in the prior art field of diathermy.The pulse of diathermy signal is follow-up to be delivered at first to can excite the electromagnetic field of non-thermal biological effect in the treatment of infectious disease.Subsequently, reported after the wound that is used to reduce soft tissue and the PFR of postoperative pain and edema, wound healing, burn treatment and neuranagenesis treatment is used.The application of PRF of traumatic edema of being used to disappear is used in recent years more and more.In animal and clinical research, use the result of PRF to show that edema can moderately be reduced owing to such electromagnetic stimulation so far.

The present invention is based on biophysics and zooscopy, it exchanges effect to organizational structure sensitivity owing to induced voltage and correlated current with cell and cell.The mathematical analysis of at least one estimation is applied to whether the EMF signal of target pathway structure (as cell, tissue, organ and molecule) is detectable in use signal to noise ratio (snr) and the PSNR power signal-to-noise ratio (Power SNR) on the thermal noise of ions binding position appearance.The dielectric characteristic of organizational structure is not considered in the EMF dosimetry of prior art, and on the contrary, prior art is utilized the characteristic of isolated cells.By utilizing dielectric characteristic, the activity coupling (reactive coupling) of the electromagnetic waveforms that SNR that estimates in the target pathway structure by optimization and Power SNR mathematical value dispose can strengthen the various effectiveness of the medicament, chemical agent, enamel and the local agent that are applied to people, animal and plant cell, organ, tissue and molecule.Potentiation comes from the blood flow of increase and adjusting and other enhanced biological effect process of angiogenesis and neovascularization.

Noinvasive PRF utilizes the impulse train of 27.12MHz sine wave in the nearest clinical use of radio frequency, the general width of showing 65 microseconds of each impulse train, and nearly 1700 sinusoidal period of every impulse train, and have different burst repetition rate.

Broad spectral density bursts with electromagnetic waveforms of the frequency in the scope of one to 100 megahertz (MHz) is selectively used for people, animal and plant cell, organ, tissue and molecule, every impulse train has 1 to 100000 pulse, and burst repetition rate is 0.01 to 10000 hertz (Hz).The voltage amplitude envelope of each impulse train be in pulse burst envelope, effectively provide broad-spectrum density at random, the function of irregular or other similar variable.The signal of consideration in specific target pathway structure and thermal noise than and the mathematical function defined variable of Power SNR.Waveform Design becomes to regulate living cells growth, state and reparation.The application-specific of these signals includes but not limited to: strengthen the effectiveness of medicament, chemical agent, enamel and local agent, the prevention of organ, muscle, joint, skin and hair and health care are handled, behind the surgical operation and the wound healing of wound, angiogenesis, the hemoperfusion that improves, vasodilation, vasoconstriction, decrease in edema, enhanced neovascularization, bone repair, tendon reparation, ligament repair, neomorph and pain relief.Can be used for strengthening the various effectiveness of such chemical compound with the application of the medicament that is applied to people, animal and plant cell, organ, tissue and molecule, chemical agent, enamel and the bonded electromagnetic waveforms of local agent.

According to embodiment of the present invention, the pulse burst envelope of higher spectral density can more effectively be coupled to the dielectric pathways that the physiology is correlated with, for example cell-membrane receptor, change with bonded ion of cellular enzymes and general transmembrane potential.Increased the quantity of the frequency component that is transferred to relevant cellular pathways according to embodiment of the present invention, the biophysics phenomenon in a big way that causes can be applicable to known healing mechanism becomes and can realize, comprises enhanced enzymatic activity, growth factor release and release of cytokines.By increase the impulse train persistent period and by use at random or the envelope of other high spectrum density to induction at every centimetre 10 ^-6And the peak value electric field between 10 volts (V/cm) and satisfy one pole that the detectability according to SNR or Power SNR requires or the pulse burst envelope of bipolar rectangle or sine pulse, the biological healing process of soft tissue in can be applicable to people, animal and plant and sclerous tissues can obtain more effective and bigger effect, causes the enhancing of the effectiveness of medicament, chemical agent, enamel and local agent.

The present invention relates to be applied to the mechanisms known of medicament, chemical agent, enamel and the local agent of people, animal and plant cell, organ, tissue and molecule.Especially, the effect of these agent depends on that described dose optimal dose reaches the target pathway structure of expection, this can by the blood flow that increases with during relevant biochemistry cascade, finished by the enhanced chemism of increase catalysis of organized enzyme.Electromagnetic field can increase described dose of active blood flow of influence and ions binding.Use a favourable result of the present invention to be, the amount of agent may reduce owing to the enhanced effectiveness of agent.The method that the purpose of this invention is to provide improvement is applied to the predictive role of medicament, chemical agent, enamel and the local agent of people, animal and plant cell, organ, tissue and molecule with enhancing and promotion, and improves its effect and other effectiveness.

Another object of the present invention is, by high spectrum density voltage envelope being applied as adjusting or the impulse train defined parameters that requires according to SNR and Power SNR, can be starkly lower than the power requirement than short burst of pulse to the power requirement of the impulse train of persistent period of such increase with same frequency range; This comes from the more effective coupling of frequency component and relevant cellular/molecular process.Therefore, obtained the advantage of the power requirement of enhanced dosimetry that is transferred to relevant dielectric pathways and reduction.

Therefore, exist the predictive role of the medicament, chemical agent, enamel and the local agent that more effectively strengthen and promote to be applied to people, animal and plant cell, organ, tissue and molecule and improve its effect and the needs of the apparatus and method of other biological effect effect.

Summary of the invention

The present invention relates to strengthen the effectiveness of the medicament, chemical agent, enamel and the local agent that are used to handle living tissue, cell and molecule by being provided for the treatment of noinvasive pulse electromagnetic to strengthen treatment, prevention and protection device and the method for living tissue physiological situation, reparation and growth in animal, people and the plant.This beneficial method is operated with the change bioelectromagnetics environment related with cell and organizational environment optionally by using calutron (as EMF generator and applicator head (applicator heads)).Comprise according to embodiment of the present invention flux path is introduced selectable body part, be included in a series of EMF pulses of the minimum width characteristic that has at least 0.01 microsecond in the pulse burst envelope, the every impulse train of described pulse burst envelope has the pulse between 1 and 100000, the voltage amplitude envelope of wherein said impulse train is by the parameter-definition of change at random, wherein instantaneous minimum radius and amplitude peak differ less than ten thousand/.Further, the repetitive rate of such impulse train can change to 10000 hertz from 0.01.The definable parameter on mathematics that satisfies the requirement of SNR and/or Power SNR detectability in target structure is used to define the configuration of impulse train.

Dielectric characteristic by considering the target pathway structure and to because the ratio of the induction field amplitude of the voltage of thermal noise or other basic cellular activity is chosen in the parameter that defines on the mathematics.

Another object of the present invention provides: use to be equipped with the waveform that satisfies SNR and the requirement of Power SNR detectability in the target pathway structure, by regulating the method that responsive adjustment process is handled living cells and tissue at cell membrane and the joint interface electromagnetism between cell.

Utilize PSNR power signal-to-noise ratio (Power SNR) method to come configure bioeffective waveforms according to the preferred embodiments of the invention, and merge miniaturized circuit and lightweight flexible coils.This advantageously allows to utilize the equipment of Power SNR approach, miniaturized circuit and lightweight flexible coils is portative fully, and if expectation be constructed to disposable, and if further expectation be constructed to implantable.

Especially, the broad spectral density bursts that is configured to the electromagnetic waveforms of acquisition maximum signal power in the band of biological targets leads to optionally is applied to target pathway structure (as tissue), to strengthen the effectiveness of medicament, chemical agent, enamel and local agent.Amplitude/the power ratio of the uniqueness of thermal noise waveform is selected waveform in use and the target pathway structure.Signal comprises in sine, rectangle, the irregular and random waveform impulse train of at least one, have the frequency capability in about 0.01Hz arrives the scope of about 100MHz, and have from about 0.01 pulse recurrence rate to about 1000 burst/sec with about 1 to 100000 pulse of per second.The peak signal amplitude of target pathway structure (as organ, cell, tissue and molecule) at about 1 μ V/cm in the scope of about 100 μ V/cm.Each signal burst envelope can be random function, and this random function provides the method for the different electromagnetic signatures that adapt to enhanced biological effect process.Comprise about 0.1 to about 100 milliseconds impulse train according to the preferred embodiments of the invention, this impulse train is included in the impulse train and arrives symmetry or the asymmetric pulses of about 100 KHz multiple about 1 to about 200 microseconds with about 0.1.Pulse envelope be the 1/f function revised and about 0.1 and about 1000Hz between use with random repetition.Fixed repetitive rate also can be used between about 0.1Hz and the about 1000Hz.Induction field from about 0.001V/cm to about 100mV/cm is produced.Another embodiment according to the present invention comprises that about 0.01 millisecond is arrived about 10 milliseconds altofrequency sinusoidal wave pulse group, for example with per second about 1 to about 100 multiple 27.12MHz of impulse train.Induction field from about 0.001V/cm to about 100mV/cm is produced.Consequent waveform can transmit by inductance or Capacitance Coupled.

Summary of the invention

An object of the present invention is to provide adjusting in the electromagnetic susceptibility adjustment process of cell membrane and the joint interface between cell.

Another object of the present invention is the effectiveness that strengthens medicament, chemical agent, enamel and local agent by means of mathematical modelling by the power spectrum of configure waveforms, use the signal to noise ratio (snr) analysis to dispose and be optimized, use then by contoured configuration equipment such as miniaturized circuit the generating equipment of power such as the waveform that the microlight-type wire coil is coupled and is disposed are provided to regulate the waveform of angiogenesis and neovascularization.

Even another object of the present invention is that the electrical equivalent in Huo Qijin (Hodgkin)-Huxley (Huxley) membrane modle is non-linear, also by using any input waveform, by estimating to regulate angiogenesis and neovascularization, to strengthen the effectiveness of medicament, chemical agent, enamel and local agent in the Power SNR of any target pathway structure (as molecule, cell, tissue and organ).

Another object of the present invention provides making of merging Power SNR and is used for controlling and regulating the device of electromagnetic curing processing with the effectiveness of enhancing medicament, chemical agent, enamel and local agent.

Another object of the present invention provides use and is applied to the electromagnetic field that biochemistry target pathway structure is selected with the adjusting that is implemented in molecule, cell, tissue and intraorganic angiogenesis and neovascularization by optimization, strengthens the method and apparatus of the effectiveness of medicament, chemical agent, enamel and local agent.

Another object of the present invention is to rely on Power SNR significantly to reduce peak amplitude and chopped pulse persistent period by the sensitivity coupling that makes frequency range and frequency response and target pathway structure (as molecule, cell, tissue and organ) in the signal, thereby the adjusting of realization angiogenesis and neovascularization is with the effectiveness of enhancing medicament, chemical agent, enamel and local agent.

Other purpose of the present invention provides the device of the application that is used for electromagnetic waveforms, use to combine, so that can strengthen the biological effect process of such chemical compound with the medicament that is applied to people, animal and plant cell, organ, tissue and molecule, chemical agent, enamel and local agent.

Other purpose of the present invention provides in order to treat, to prevent and keeping healthy purpose and strengthen the method for the effectiveness of medicament, chemical agent, enamel and local agent.

Other purpose of the present invention provides and is used for the method for using EMF to come treatment of organs, muscle, joint, skin and hair with the effectiveness that improves these agent in conjunction with medicament, chemical agent, enamel and local agent.

Other purpose of the present invention provides and is used for using EMF to come the method for treatment of organs, muscle, joint, skin and hair to strengthen health in conjunction with medicament, chemical agent, enamel and local agent.

Other purpose of the present invention provides wherein the method that requires to dispose electromagnetic waveforms according to the SNR in the target pathway structure and Power SNR detectability.

Other purpose of the present invention provides the method for the electromagnetic curing that is used to comprise broadband, high broad-spectrum density electromagnetic field.

Other purpose of the present invention provides by using EMF to strengthen the method for soft tissue and hard tissue repair in conjunction with medicament, chemical agent, enamel and local agent.

Other purpose of the present invention provides by using electromagnetic curing to be increased to by the blood flow of the tissue of disease infection to regulate angiogenesis, with the method for the effectiveness that strengthens medicament, chemical agent, enamel and local agent.

Other purpose of the present invention provides increases the method for blood flow with the effectiveness of enhancing medicament, chemical agent, enamel and local agent, and viablity, growth and the differentiation of cell, tissue and the organ transplanted regulated in these agent.

Other purpose of the present invention provides by regulating angiogenesis and increasing blood flow is treated cardiovascular disease with the effectiveness that strengthens medicament, chemical agent, enamel and local agent method.

Other purpose of the present invention provides by improving the blood capillary hemoperfusion and reducing the method for oozing out the physiological effectiveness that increases medicament, chemical agent, enamel and local agent.

Other purpose of the present invention provides increases blood flow is used for the treatment of medicament, chemical agent, enamel and the local agent of skeleton and sclerous tissues's disease with enhancing the method for effectiveness.

Other purpose of the present invention provides increases blood flow is used for the treatment of medicament, chemical agent, enamel and the local agent of the edema of soft tissue and swelling with enhancing the method for effectiveness.

Other purpose of the present invention provides increases blood flow is used to repair medicament, chemical agent, enamel and the local agent of damaged soft tissue with enhancing the method for effectiveness.

Other purpose of the present invention provides by regulating the method that vasodilation and stimulation neovascularization are increased to the blood flow of damaged tissues thereby strengthen the effectiveness of medicament, chemical agent, enamel and local agent.

Other purpose of the present invention provides electromagnetic treatment apparatus, and wherein said device uses the power level that reduces to operate.

Another object of the present invention provides electromagnetic treatment apparatus, and wherein said device is cheap and portative, and produces the electromagnetic interference that reduces.

According to Short Description, detailed description of the present invention and the herewith appended claim of the accompanying drawing of hereinafter setting forth, of the present invention above and also have other purpose and advantage will become obvious.

The accompanying drawing summary

Below with reference to accompanying drawing the preferred embodiments of the invention are described in more detail:

Fig. 1 is the flow chart according to the method for the effectiveness that is used to strengthen the medicament, chemical agent, enamel and the local agent that are used for handling living tissue, cell and molecule of embodiment of the present invention;

Fig. 2 is the view that is applied to kneed control circuit and electric coil according to the preferred embodiments of the invention;

Fig. 3 is the structure chart according to the miniaturized circuit of the preferred embodiments of the invention;

Fig. 4 A is according to the wire coil of the preferred embodiments of the invention such as the string diagram of induction apparatus:

Fig. 4 B is the string diagram according to the flexible magnetic wire of the preferred embodiments of the invention;

Fig. 5 describes to be delivered to for example waveform of molecule, cell, tissue or organ of target pathway structure according to the preferred embodiments of the invention;

Fig. 6 is according to the positioning equipment of the preferred embodiments of the invention such as the view of wrist support;

Fig. 7 is according to the positioning equipment of the preferred embodiments of the invention such as the view of mattress cushion;

Fig. 8 is the curve chart of demonstration according to the effect of the impulse train persistent period of the increase of embodiment of the present invention;

Fig. 9 is the curve chart that shows the dabbling increase of skin blood that obtains according to embodiment of the present invention.

The specific embodiment

Provide higher spectrum density according to embodiment of the present invention to pulse burst envelope, caused the enhanced treatment of relevant dielectric pathways (for example cell-membrane receptor, change with bonded ion of cellular enzymes and general transmembrane potential) is renderd a service.Increased the quantity of the frequency component that is transferred to relevant cellular pathways according to embodiment of the present invention, thereby the chance that provides contact to can be applicable in a big way the biophysics phenomenon of known healing mechanism, for example adjusting of somatomedin and release of cytokines and in the ions binding of regulating the molecule place.According to mathematical model by the definition of the SNR in transduction pathway or Power SNR, by will be at random or other high spectrum density envelope be applied to induction at every centimetre 10 ^-6And the pulse burst envelope of the one pole of the peak value electric field between 10 volts (V/cm) or bipolar rectangle or sine pulse, can reach bigger effect to the biological agglutination that can be applicable to soft tissue and sclerous tissues, thereby strengthen the effectiveness of medicament, chemical agent, enamel and local agent.

A favourable outcome of the present invention is, according to mathematical model by SNR in transduction pathway or Power SNR definition, by using high spectrum density voltage envelope, can be starkly lower than the power requirement of the unmodulated impulse train that is included in the pulse in the identical frequency range to the power requirement of such amplitude adjusted impulse train as regulating or the impulse train defined parameters.Therefore, obtained the advantage of the power requirement of enhanced dosimetry that is transferred to relevant dielectric target approach and reduction.

Additional advantage of the present invention relates to by promoting described dose expection to render a service and the raising effect, strengthens the effectiveness of the medicament, chemical agent, enamel and the local agent that are applied to people, animal and plant cell, organ, tissue and molecule.

The electric current that changes from sensitive time of PEMF or PRF equipment for example flows in molecule, cell, tissue and the organ in the target pathway structure, and these electric currents are a kind of stimulations, and cell and tissue can react to this stimulation with physiology's meaningful ways.The electrical characteristics of target pathway structure influence faradic level and distribution.Molecule, cell, tissue and organ all the faradic current approach as the cell in slot engagement contacts in.At ion that can reside in the binding site place on the lip-deep macromole of film or ligand interaction is the process that relies on voltage, for example can be in response to the electrochemistry of induction field (E).Faradic current arrives these positions by ionic medium on every side.The existence of cell makes faradic current (J) along with the time (J (t)) decays comparatively fast in current pathway.This is owing to transport from the electrical impedance of the increase of the cell of membrane capacitance and bonded time constant and other voltage-sensitive membrane process such as film.

The equivalent-circuit model of representing different films and charged interface configurations is obtained.For example, at calcium (Ca ²⁺) in conjunction with in since the induction E, the bonded Ca at the binding site place ²⁺Concentration change can be in frequency domain describe by impedance expression, as:

$Z_b\left(\mathrm{\ω}\right)=R_{\mathrm{ion}}+\frac{1}{\mathrm{i\ω}{C}_{\mathrm{ion}}}$

It has the form of the equivalent circuit of series resistance-electric capacity.Wherein ω is the angular frequency that is defined as 2 π f, and f is a frequency, i=-1 ^1/2, Z _b(ω) be combined impedance, and R _IonAnd C _IonBe the electric capacity of equivalence in conjunction with resistance and ions binding approach.The value τ of equivalence binding time constant _Ion=R _IonC _IonPass through τ _Ion=R _IonC _Ion=1/k _bRelevant with ions binding rate constant.Therefore, the characteristic time constant of this approach is determined by ions binding kinetics.

Induction E from PEMF or PRF signal can make electric current inflow ions binding approach and influence the bonded Ca of time per unit ²⁺Ionic quantity.Its electrical equivalent is in conjunction with capacitor C in equivalence _IonThe change in voltage at two ends, this is by C _IonThe direct measurement of the change in electrical charge that stores.Electric charge and Ca in binding site ²⁺Ionic surface concentration is in direct ratio, that is, the storage of electric charge is equivalent to the storage of ion or other charged matter on cell surface and joint.The direct driving force credit of impedance bioelectrical measurement and combination rate constant is analysed to provide to configuration PMF waveform leads to the band with the target pathway structure and is mated the time necessary constant value.This considers the desired frequency range to any given induction E waveform, and is logical as being with to the target impedance with Best Coupling.

With regulating the bonded ion of molecule is common EMF target, for example with the bonded Ca of calmodulin, CaM ²⁺(CaM).The use of this approach is to promote tissue repair (for example reparation of bone healing, wound healing, hair reparation and molecule, cell, tissue and organ), and these reparations relate to the adjusting of the somatomedin that discharges in the difference reparation phase.Somatomedin for example platelet derived growth factor (PDGF), fibroblast growth factor (FGF) and epidermal growth factor (EGF) is all related at suitable healing stage.Angiogenesis and neovascularization are also necessary to tissue growth and reparation, and can be regulated by PMF.All these factors all are that Ca/CaM is dependent.

Utilize the configurable waveform of Ca/CaM approach, for this waveform, induced power is fully greater than the background heat noise power.Under suitable physiological condition, this waveform can have significant biological effect on physiology.

Power SNR model is to the application need of the Ca/CaM Ca at CaM ²⁺The knowledge of the electrical equivalent of binding kinetics.In the one-level binding kinetics, at the bonded Ca of CaM binding site ²⁺Concentration over time can be by equivalent binding time constant τ in frequency domain _Ion=R _IonC _IonCharacterization, wherein R _IonAnd C _IonBe the electric capacity of equivalence in conjunction with resistance and ions binding approach.τ _IonPass through τ _Ion=R _IonC _Ion=1/k _bWith ions binding rate constant k _bRelevant.k _bPublished value can be used on then in the cellular array model, to estimate SNR by the voltage that relatively causes by the PRF signal and heat fluctuation at the voltage of CaM binding site.Use the umerical value of PMF response, as V _Max=6.5x10 ^-7Sec ^-1, [Ca ²⁺]=2.5 μ M, K _D=30 μ M, [Ca ²⁺CaM]=K _D([Ca ²⁺]+[CaM]), obtain k _b=665sec ^-1(τ _Ion=1.5msec).Such τ _IonValue can be used in the equivalent circuit of ions binding, and the Power SNR analysis can be performed to be used for any waveform configuration.

According to embodiment of the present invention, mathematical model for example mathematical equation and/or a series of mathematical equation can be configured to absorb the thermal noise that appears in all processes relevant with voltage, and the expression minimum threshold requirement of setting up enough SNR.For example the power spectral density that mathematical model that the minimum threshold of enough SNR requires can be configured to comprise thermal noise is set up in expression, so the power spectral density S of thermal noise _n(ω) can be expressed as:

S _n(ω)＝4kTRe[Z _M(x，ω)]

Z wherein _M(x ω) is the electrical impedance of target pathway structure, and x is the dimension of target pathway structure, and Re represents the real part of impedance of target pathway structure.Z _M(x ω) can be expressed as:

$Z_M(x,\mathrm{\ω})=\left[\frac{R_e+R_i+R_g}{\mathrm{\γ}}\right]\tanh \left(\mathrm{\γx}\right)$

This equation is clearly shown that the electrical impedance of target pathway structure and all promotes noise filtering from the contribution (these resistance are electrically connected to the target pathway structure) of extracellular fluid bulk resistor (Re), intracellular fluid bulk resistor (Ri) and intermembranous resistance (Rg).

Estimate the monodrome of conventional method use root-mean-square (RMS) noise voltage of SNR.This is by getting S on all relevant with complete film reaction or relevant with the bandwidth of target pathway structure frequencies _n(ω)=4kTRe[Z _M(x, ω)] the square root of integration calculate.SNR can be represented by ratio:

$\mathrm{SNR}=\frac{\left|V_M\left(\mathrm{\ω}\right)\right|}{\mathrm{RMS}}$

Wherein | V _M(ω) | be when chosen Frequency Transfer amplitude peak at each frequency place voltage when the target pathway structure.

Embodiment of the present invention comprise the pulse burst envelope with high spectrum density, so as to strengthen to relevant dielectric pathways (as cell-membrane receptor, with the bonded ion of cellular enzymes and transmembrane potential change) therapeutic effect.Therefore, be transferred to a lot of frequency components of relevant cellular pathways by increase, the large-scale biophysics phenomenon (for example regulate somatomedin and release of cytokines and in the ions binding of regulating molecule) that can be applicable to known tissue growth mechanism is attainable.According to embodiment of the present invention, will be at random or other high spectrum density envelope be applied to induction about 10 ^-8And the one pole of the peak value electric field between about 100 volts of V/cm or the pulse burst envelope of bipolar rectangle or sine pulse, the biological agglutination that can be applicable to soft tissue and sclerous tissues is produced bigger effect.

According to another embodiment of the present invention, regulate or the impulse train defined parameters by high spectrum density voltage envelope is applied as, can be starkly lower than the not regulating impulse group's of the pulse that comprises in the similar frequency range power requirement to the power requirement of the impulse train of such amplitude adjusted.This be because, by with irregular, at random the amplitude of being preferably is imposed to otherwise be essentially uniform pulse burst envelope, has produced the substantial minimizing in the intrachain dutycycle of repetitive burst.Therefore, obtained the two-fold advantage of the power requirement of enhanced dosimetry that is transferred to relevant dielectric pathways and reduction.

With reference to figure 1, wherein Fig. 1 is the flow chart according to the method for embodiment of the present invention, in order to treat and prevent purpose, this method is used for strengthening the effectiveness of the medicament, chemical agent, enamel and the local agent that are used to handle stem cell, tissue, cell, organ and molecule by being delivered to target pathway structure (as animal and human's ion and part) by the electromagnetic signal that pulsation ground produces.The target pathway structure also can include but not limited to stem cell, tissue, cell, organ and molecule.The effectiveness that strengthens medicament, chemical agent, enamel and local agent includes but not limited to increase absorbance, reduces actual dose, accelerates the transport in the organism level, and the binding kinetics and the transmission kinetics level that are increased in molecule and cellular level.

At least a activating agent is applied to target pathway structure (step 101).Activating agent includes but not limited to medicament, chemical agent, enamel, local agent and genetic agents.Activating agent can be by oral, topical application, use at intravenous, intramuscular is used or by medical circle in known material and the interactional any alternate manner of target pathway structure of making, as iontophoresis, X-radiation and light radiation and heating.Medicament includes but not limited to antibiotic, somatomedin, chemotherapeutant, hydryllin, angiotensin inhibitor, beta-blocker, inhibin and anti-inflammatory agent.Chemical agent includes but not limited to hydrogen peroxide, polyvidon sulphur (betadine) and alcohol.Local agent includes but not limited to antibiotic, Emulsion, retinal, benzoyl peroxide, tolnaftate, menthol, emollient, oil preparation, lanoline, zamene, Aloe (aloe vera), antioxidant, fatty acid, fatty acid ester, code-liver oil, alpha-tocopherol, oil, hydrogenated polybutene, vitamin A, vitamin E, local protein and collagen.Enamel includes but not limited to cosmetics, eyelid China ink and kermes.Genetic agents includes but not limited to gene, DNA and chromosome.

At least one contoured configuration that will have at least one waveform parameter becomes to be coupled to target pathway structure such as ion and part (step 102).

Described at least one waveform parameter is chosen to maximize in signal to noise ratio in the target pathway structure and the PSNR power signal-to-noise ratio at least one, so that the waveform in the target pathway structure is at for example basic voltage heat fluctuation of background activity be detectable (step 102) on the electrical impedance of target pathway structure, background activity depends on the state of cell and tissue, promptly, whether this state is at least a of rest, growth, displacement and response damage, to be created in useful result on the physiology.In order in the target pathway structure, to be detectable, the value of described at least one waveform parameter can be selected by the constant that uses described target pathway structure, come in estimated snr and the PSNR power signal-to-noise ratio at least one, to compare elementary heat fluctuation and electrical impedance by the voltage of described at least one waveform influence in described target pathway structure and the voltage in described target pathway structure, thus by the band of maximization in described target pathway structure in described signal to noise ratio in logical and the PSNR power signal-to-noise ratio at least one, by means of described at least one waveform, biological effect adjusts in the present described target pathway structure.

The preferred embodiment of the electromagnetic signal that is produced comprises the impulse train of the random waveform with at least one waveform parameter, this waveform parameter comprises the frequency component of a plurality of scopes from about 0.01Hz to about 100MHz, and wherein said a plurality of frequency components satisfy Power SNR model (step 103).For example multiple electromagnetic signal can be by described at least one waveform inductive or generation (step 104) capacitively.Electromagnetic signal also can be non-repeatability.Electromagnetic signal is coupled to the target pathway structure by the output of the Coupling device (as electrode or induction apparatus) closely placed with the target pathway structure utmost point, as ion and part (step 105).The coupling of electromagnetic signal and target pathway structure can additionally appear at any moment before the application of active agents for example, when activating agent is employed or after the time that activating agent is employed.This coupling has increased the bonded adjusting of adjusting molecule in blood flow and ion and part and molecule, tissue, cell and the organ, thereby has strengthened the biopotency of activating agent.

Fig. 2 illustrates the preferred embodiment according to device of the present invention.This device be independently, light-duty with portative.Small-sized control circuit 201 is coupled to the end of at least one adapter 202 as metal wire, but but also radio operation of control circuit.A relative end of described at least one adapter is coupled to generating equipment such as electric coil 203.Small-sized control circuit 201 constitutes in the mode of applied mathematical model, and this model is used for configure waveforms.The waveform that is disposed must satisfy Power SNR, so that for given and known target pathway structure, might select to satisfy the waveform parameter of Power SNR, make on the waveform generation physiology useful result (adjusting of biological example effect) and be detectable in the target pathway structure on background activity.Come induction mM disodium hydrogen phosphate and time dependent electric field in target pathway structure (as ion and part) according to the preferred embodiments of the invention applied mathematical model, comprise that arriving about 0.1 of about 100 microsecond rectangular pulses with per second about 0.1 to about 100 pulses multiple about 1 arrives about 100 milliseconds impulse train.The peak amplitude of induction field is between about 1 μ V/cm and about 100mV/cm, according to the 1/f equation variation of change, wherein f=frequency.Be configured to use the waveform according to the preferred embodiments of the invention to can be applicable to target pathway structure (as ion and part), preferred total irradiation time is 1 minute to 240 minutes every day.Yet can use other irradiation time.Waveform by small-sized control circuit 201 configurations is directed into generating equipment 203 as electric coil by adapter 202.Generating equipment 203 transmission can be used for providing to target pathway structure such as tissue the pulsed magnetic field of treatment.The one section official hour in small-sized control circuit apply pulse magnetic field also can be by needed (for example a day 10 times) and the repeated application pulsed magnetic field automatically repeatedly used in the given time period.The small-sized control circuit in repetitive sequence apply pulse magnetic field can be configured to programmable with any time.Can be according to the preferred embodiments of the invention by merging to the effectiveness that strengthens medicament, chemical agent, enamel and local agent in positioning equipment 204 as the bed.Pulsed magnetic field is coupled to target pathway structure such as ion and part, on treatment and prevent disease, reduced inflammation, thereby advantageously reduced pain, promoted healing in the target site and the interaction that strengthened medicament, chemical agent, enamel and local agent and target pathway structure.When electric coil was used as generating equipment 203, according to Faraday's law, the mM disodium hydrogen phosphate that is used in the time dependent electric field of induction in the target pathway structure can provide power to electric coil.Also can use electromagnetic coupled to use the electromagnetic signal that is produced by generating equipment 203, wherein electrode directly contacts with the other external electric conducting border of skin or target pathway structure.In another embodiment according to the present invention, also can use static to be coupled and use the electromagnetic signal that produces by generating equipment 203 in addition, wherein between generating equipment 203 is as electrode and target pathway structure such as ion and part, have the air gap.Advantage according to the preferred embodiments of the invention is that its microlight-type coil and miniaturized circuit allow to be used for the General Physics Therapeutic Method, and are used for the place of any desired growth, pain relief and tissue and organ healing.Favourable outcome according to the application of the preferred embodiments of the invention is, tissue growth, reparation and maintenance can be anywhere and finished at any time and strengthen, for example when driving or seeing TV.The another favourable outcome of the application of preferred embodiment is, the growth of molecule, cell, tissue and organ, reparation and maintenance can be anywhere and finished at any time and strengthen, for example when driving or seeing TV.

Fig. 3 has described the structure chart according to the small-sized control circuit 300 of the preferred embodiments of the invention.Small-sized control circuit 300 produces the waveform that drives generating equipment (as the top wire coil of describing) in Fig. 2.Small-sized control circuit can be triggered by any flip flop equipment (as on/off switch).Small-sized control circuit 300 has power supply such as lithium battery 301.The preferred embodiment of power supply has 3.3 volts output voltage, but also can use other voltage.In another embodiment according to the present invention, power supply can be for example current and power supply socket of external power source, as be coupled to AC/DC supply socket of the present invention by plug and electric wire.Switching Power Supply 302 controls to the voltage of microcontroller 303.The preferred embodiment of microcontroller 303 is used the microcontroller of 8 bit 4MHz, but can use the combination microcontroller of other bit MHz.Switching Power Supply 302 also can convey electrical current to reservior capacitor 304.The preferred embodiments of the invention are used the reservior capacitor with 220 μ F output, but can use other output.Reservior capacitor 304 allows high-frequency impulse to be transported to Coupling device such as induction apparatus (not shown).Microcontroller 303 also control impuls forms device 305 and impulse phase timing controlled 306.Pulse shaper 305 and impulse phase timing controlled 306 are determined pulse shape, burst width, pulse burst envelope shape and burst repetition rate.The generator of integrated waveform generator such as sine wave or any amount also can be merged so that specific waveform to be provided.307 controls of voltage level conversion electronic circuit are delivered to the induction field of target pathway structure.Switch Hexfet308 allows the impulse train of pulses of randomized amplitude to be passed to the output 309 that waveform is sent at least one Coupling device such as induction apparatus.Total irradiation time that microcontroller 303 is gone back the seance of may command target pathway structure such as molecule, cell, tissue and organ.Small-sized control circuit 300 can be configured to programmable and the one section official hour in apply pulse magnetic field, and presses needed repeatedly application (for example a day 10 times) in the given time period and automatic repeated application pulsed magnetic field.Use about 10 minutes to about 30 minutes treatment time according to the preferred embodiments of the invention.

With reference to figure 4A and Fig. 4 B, it illustrates Coupling device 400 according to the preferred embodiments of the invention as induction apparatus.Coupling device 400 can be the electric coil 401 that twines with sub-thread or multiply flexible wire 402, yet also can use solid wire.In according to the preferred embodiments of the invention, metal wire is made of copper, but also can use other material.Multiply flexible magnetic wire 402 makes electric coil 401 can meet specific anatomical structure such as human or animal's the limb wing or joint.The preferred embodiment of electric coil 401 comprise the about 0.01mm of diameter in the sub-thread magnetic metal wire of about 0.1mm and the multiply magnetic metal wire at least one about 1 to about 1000 circles, metal wire is wrapped on the structure that is initially circle of the outer dia that has between about 2.5cm and the about 50cm, but also can use the circle and the wire diameter of other quantity.The preferred embodiment of electric coil 401 can be wrapped up with nontoxic PVC mold 403, but also can use other non-toxic moulds.Electric coil also can be incorporated in dressing, binder, clothes and generally be used for other structure of Wound healing and bone regeneration.

With reference to figure 5, it illustrates the waveform 500 according to embodiment of the present invention.Pulse 501 repeats in the impulse train 502 with finite duration.Such persistent period 503 makes the dutycycle of the ratio that can be defined as impulse train persistent period and signal period about 1 to about 10 ^-5Between.Utilize accurate rectangle 10 microsecond pulses to arrive about 50 milliseconds according to the preferred embodiments of the invention as the pulse 501 about 10 that is used in the impulse train 502, impulse train 502 has the 1/f amplitude envelops 504 of change and has corresponding to about 0.1 the finite duration 503 in impulse train cycle between about 10 seconds, but can use other waveform, envelope and the impulse train cycle of following mathematical model such as SNR and Power SNR.

Fig. 6 illustrates according to positioning equipment of the preferred embodiments of the invention such as wrist support.Positioning equipment 600 (as wrist support 601) is worn on people's the wrist 602.That positioning equipment can be configured to is portative, can be configured to disposable maybe can be configured to implantable.Positioning equipment can be used in combination with the present invention in many ways, for example by sewing up the present invention is integrated with in the positioning equipment, for example passes through Append to the present invention on the positioning equipment and the present invention is kept in place by positioning equipment is configured to elasticity.

In another embodiment according to the present invention, the present invention can be configured to have or do not have the stand-alone device of the virtually any size of positioning equipment, for example is in to be used in Anywhere, in the clinic, in therapeutic community or outdoor.Wrist support 601 can be with any dissection and for example neoprene manufacturing of support material.Coil 603 is integrated with in the wrist support 601, makes the signal (waveform of for example describing in Fig. 5) of the configuration according to the present invention be applied to the sole of the foot portion into the wrist bottom from the back at wrist top.Use ruggedized equipment as (not shown) is attached to microcircuit the outside of wrist support 601.Microcircuit is coupled to an end of at least one connection device such as flexible wire 605.The other end of described at least one connection device is coupled to coil 603.Positioning equipment according to other embodiments of the present invention comprises knee joint, elbow, lower back, shoulder, other dissection wrappage and medicated clothing for example clothes, fashion accessory and footgear.

With reference to figure 7, it illustrates the electromagnetic treatment apparatus of integrating with mattress cushion 700 according to embodiment of the present invention.Also can use mattress.Some lightweight flexible coils 701 are integrated with mattress cushion.Lightweight flexible coils 701 can be made of fine and soft property conductive metal wire, conductive filament and any other flexible conducting material.Flexible coil is connected at least one end of at least one metal wire 702.Yet flexible coil also can be configured to be directly connected to circuit 703 or wireless connections.Be connected to the other end at least of described at least one metal wire according to the light-duty miniaturized circuit 703 of embodiment of the present invention configure waveforms.When triggering light-duty miniaturized circuit 703, the waveform that configuration is directed into flexible coil (701) is coupled to the PEMF signal of target pathway structure with generation.

Embodiment 1

The myosin phosphorylation that is used for the Ca-dependent of standard enzyme analysis according to the embodiment of the EMF of being used for signal configures of the present invention.Known this enzymatic pathway strengthens the effectiveness of the medicament, chemical agent, enamel and the local agent that are applied to people, animal and plant cell, organ, tissue and molecule.For the phosphorylation rate is linear in the time of a few minutes and is sub-saturated Ca ²⁺Concentration is come choice reaction mixture.In the time of in occurring in damage or owing to use medicament, chemical agent, enamel and the local agent that is applied to people, animal and plant cell, organ, tissue and molecule, this is the Ca to the EMF sensitivity ²⁺/ CaM has opened biological window.Use experimentizes from isolating myosin light chain of turkey gizzard (MLC) and myosin light chain kinase (MLCK).Reactant mixture mainly is made up of following material: comprise 40mM Hepes buffer solution, pH and be 7.0 basic solution; 0.5mM ammonium acetate; The 1mg/ml bovine serum albumin, 0.1% (w/v) Tween 80; And 1mM EGTA.Free Ca ²⁺In 1-7 μ M scope, change.In case set up Ca ²⁺Buffering, freshly prepared 70nM CaM, 160nM MLC and 2nM MLCK are added to basic solution to form final reactant mixture.

Reactant mixture fresh preparation every day to be being used for the experiment of each series, and is divided into the part of 100 μ L and the 1.5ml Eppendorf that packs into pipe.All Eppendorf pipes that comprise reactant mixture are maintained at 0 ℃, and the lasting perfusion that is transferred to then by passing the water that Fisher Scientific model 900 heat exchangers are preheated maintains 37 ± 0.1 ℃ specially designed water-bath.Use is immersed in a thermistor detector (as Cole-Parmer model 8110-20) in the Eppendorf pipe at all experimental sessions and comes monitoring temperature.Reaction starts with 2.5 μ M 32P ATP, and stops with the Laemmli sample buffer solution that comprises 30 μ M EDTA.The minima of five blank samples of counting in each experiment.Blank comprises and deducts active component Ca ²⁺, one of CaM, MLC or MLCK whole analysis of mixtures.Phosphorylation was allowed to carry out 5 minutes and was integrated among the MLC by using TM analytical model 5303 Mark V liquid scintillation counters to count ³²P and being estimated.

Signal comprises the repetitive burst of high frequency waveforms.Amplitude is kept constant at 0.2G, and is 1 burst/sec to all irradiation repetitive rate.According to the estimation of explanation when the mathematical analysis of the present invention of time acquisition best power SNR near 500 μ sec of impulse train persistent period, the impulse train persistent period changes to 1000 μ sec from 65 μ sec.The result is presented among Fig. 8, is that the burst width 801 of unit is indicated on the x axle with μ sec wherein, and myosin phosphorylation 802 is indicated on the y axle as treatment/contrasts (treated/sham).Can see that PMF is to Ca ²⁺Approach its maximum when the about 500 μ sec with the bonded effect of CaM, just shown in Power SNR model.

These results confirm, for the impulse train persistent period of the best power SNR that is enough to obtain given magnetic field amplitude, will increase the effectiveness of the medicament, chemical agent, enamel and the local agent that are applied to people, animal and plant cell, organ, tissue and molecule to greatest extent according to the EFM signal of embodiment of the present invention configuration.

Embodiment 2

Originally determine and use the treatment of pulsed electromagnetic frequency (PEMF) waveform what degree the hemoperfusion in the position of being treated is had influence on.Finish all tests in the room (23 to 24 ℃) of control temperature, the patient is sitting on the comfortable chair freely.On every arm, nonmetal laser-Doppler detector is fixed to from the about 5cm of the fossa cubitalis middle forearm position far away with two-sided tape.The temperature sensing critesistor that is used for surface temperature measurement is placed on from the about 1cm of the outward flange place far away of probe, and the blended rubber band is fixed.The towel tegmentum on each forearm to reduce the direct influence of any flow air stream.The patient cosily has a rest, and the skin temperature of every arm is monitored.During the interval of this monitoring, the excitation coil that is used to produce the PEMF waveform according to the present invention be positioned directly in vertical distance from the about 2cm of skin surface right forearm the laser-Doppler detector above.When the skin temperature of being monitored arrived the value of steady statue, data acquisition phase began.This mainly is made of at interval 20 minute basic time of being followed by 45 minutes intervals, wherein uses the PEMF waveform.

Interval with 5 minutes during whole process writes down skin temperature.Be presented on the chart recorder constantly with the definite blood perfusion signals of laser Doppler flowmeter (LDF), and obtained simultaneously by the computer of following the analog to digital conversion.The LDF signal was got time average by computer during the measuring intervals of TIME in successive 5 minutes at each, to produce the signal averaging perfusion value to each interval.When process finishes, measure relative magnetic field strength at skin part, the loop coupling of 1cm diameter is to the metering system of special design and calibration.

For each patient, the basic perfusion of treatment arm and control arm is measured as meansigma methods interim basic time of 20 minutes.After PEMF treatment beginning, perfusion value subsequently is represented as the percent of this benchmark.Arm is treated in the use variable analysis and to the comparison between the arm, arm is as grouping variable (treatment and contrast), and follow-up measurement of time.

Fig. 9 has summarized the time course of the perfusion variation that 9 patients are found during treating, time-tagging is on x axle 901, and perfusion is indicated on the y axle 902.Analyze the significant treatment-time interphase interaction (P=0.03) of demonstration, after 40 minutes PEMF treatment, the hemoperfusion in the arm of being treated is (P＜.01) improve significantly.Substantially dabbling absolute value (mv) does not have difference between control arm and treatment arm.Also show total variances between treatment arm and the control arm (P＜.01) by the basic perfusion of absolute unit (mv) as the covariance analysis of covariance.

Originally the main discovery of investigating is that when being employed in this way, the PEMF treatment is associated with the dabbling remarkable increase of skin of forearm blood capillary of having a rest.When with the treatment of having a rest before level relatively the time, this of average about 30% occurs after being increased in about 40 minutes of treatment, but do not have so tangible increase in the arm of the non-treatment of offside.This allows to increase medicament, chemical agent, enamel and the local agent flow to intended tissue target.

Described the embodiment of the apparatus and method that are used to strengthen pharmacological action, noted, those skilled in the art can make amendment and change according to top instruction.Therefore, should be understood that in the scope and spirit of the present invention that the change carried out in disclosed particular of the present invention is being defined by the following claims.

Claims (41)

1. method that is used to strengthen pharmacological action, it comprises step:

At least a activating agent is applied to the target pathway structure;

At least one waveform that configuration has at least one waveform parameter;

Select the value of described at least one waveform parameter of described at least one waveform, in the applied target pathway structure of described activating agent, to maximize in signal to noise ratio and the PSNR power signal-to-noise ratio at least one;

Use maximizes in described signal to noise ratio and the PSNR power signal-to-noise ratio described at least one waveform of at least one in the target pathway structure, to produce electromagnetic signal; With

Described electromagnetic signal is coupled to described target pathway structure to regulate described target pathway structure.

2. the method for claim 1, that the step of at least a activating agent of wherein said application comprises is oral, in intravenous injection, intramuscular injection and the topical application at least one.

3. the method for claim 1, wherein said activating agent comprises in medicament, chemical agent, local agent, enamel and the genetic agents at least one.

4. the method for claim 1, wherein said at least one waveform parameter comprises at least one following parameter: with multiple frequency component parameter between described at least one contoured configuration Cheng Zaiyue 0.01Hz and the about 100MHZ, follow the impulse train amplitude envelops parameter of the amplitude function that on mathematics, defines, the burst width parameter that changes at each place of repetition according to the width function that defines on the mathematics, the peak induction electric pulse field parameter that in described target pathway structure, between about 1 μ V/cm and about 100mV/cm, changes according to the function that defines on the mathematics, and the peak induction magnetoelectricity field that in described target pathway structure, between about 1 μ T and about 0.1T, changes according to the function that defines on the mathematics.

5. method as claimed in claim 4, the amplitude function of wherein said definition comprise in 1/f frequency function, logarithmic function, chaotic function and the exponential function at least one.

6. the method for claim 1, wherein said target pathway structure comprises in stem cell, molecule, cell, tissue, organ, ion and the part at least one.

7. the method for claim 1, it further comprises ion and part are combined step with the effectiveness that strengthens described activating agent with the adjusting molecule.

8. method as claimed in claim 7, the bonded step of wherein said ion and part comprise regulates combining of calcium and calmodulin, CaM.

9. method as claimed in claim 7, the bonded step of wherein said ion and part comprise the generation of regulating somatomedin in the target pathway structure.

10. method as claimed in claim 7, the bonded step of wherein said ion and part comprise regulates production of cytokines in the target pathway structure.

11. method as claimed in claim 7, the bonded step of wherein said ion and part comprises somatomedin and the cytokine that adjusting is relevant with tissue growth, reparation and maintenance.

12. comprising, method as claimed in claim 7, the bonded step of wherein said ion and part regulate angiogenesis and neovascularization, to strengthen the effectiveness of described activating agent in described target pathway structure.

13. the method for claim 1, it comprises that further application standard naturopathy method strengthens the step of the effectiveness of described activating agent.

14. method as claimed in claim 13, wherein the standard physical Therapeutic Method comprises in heating, cooling, compressing, massage and the exercise at least one.

15. the method for claim 1, it comprises that further increasing ion and part transports step with the effectiveness that strengthens described activating agent to the extracellular of regulating molecule.

16. the method for claim 1, it further comprises increases ion and part to the transmembrane transport of the adjusting molecule step with the effectiveness that strengthens described activating agent.

17. the method for claim 1, the step of the described electromagnetic signal of wherein said coupling comprise additional coupling.

18. the method for claim 1, it further comprises the step of application standard therapeutic treatment with the effectiveness that strengthens described activating agent.

19. method as claimed in claim 18, wherein the standard medical treatment comprises in tissue transplantation and the organ transplantation at least one.

20. an electromagnetic treatment apparatus that is used to strengthen pharmacological action, it comprises:

Waveform generating apparatus, its generation have at least one waveform of at least one waveform parameter, described at least one waveform parameter can be selected to the interactional target pathway structure of activating agent in maximization signal to noise ratio and the PSNR power signal-to-noise ratio at least one; With

Be connected to the Coupling device of described Waveform generating apparatus, it is used for from least one described at least one waveform generation electromagnetic signal described target pathway structure described signal to noise ratio of maximization and PSNR power signal-to-noise ratio, and be used for described electromagnetic signal is coupled to described target pathway structure, thereby regulate described target pathway structure.

21. electromagnetic treatment apparatus as claimed in claim 20, wherein said at least one waveform parameter comprises at least one following parameter: described at least one contoured configuration is become according to mathematical function multiple frequency component parameter between about 0.01Hz and about 100MHZ, follow the impulse train amplitude envelops parameter of the amplitude function that on mathematics, defines, the burst width parameter that changes at each place of repetition according to the width function that defines on the mathematics, the peak induction electric pulse field parameter that in described target pathway structure, between about 1 μ V/cm and about 100mV/cm, changes according to the function that defines on the mathematics, and the peak induction magnetoelectricity field parameter that in described target pathway structure, between about 1 μ T and about 0.1T, changes according to the function that defines on the mathematics.

22. electromagnetic treatment apparatus as claimed in claim 21, the amplitude function of wherein said definition comprise in 1/f frequency function, logarithmic function, chaotic function and the exponential function at least one.

23. electromagnetic treatment apparatus as claimed in claim 20, wherein said target pathway structure comprises in stem cell, molecule, cell, tissue, organ, ion and the part at least one.

24. electromagnetic treatment apparatus as claimed in claim 20, wherein said activating agent comprise in medicament, chemical agent, local agent, enamel and the genetic agents at least one.

25. electromagnetic treatment apparatus as claimed in claim 20, wherein said Coupling device comprise in active Coupling device, inductive coupled device, Capacitance Coupled equipment and the biochemistry Coupling device at least one.

26. electromagnetic treatment apparatus as claimed in claim 20, wherein said Coupling device is coupled to described target pathway structure with described signal, to regulate combining of calcium and calmodulin, CaM, strengthens the effectiveness of described activating agent.

27. electromagnetic treatment apparatus as claimed in claim 20, wherein said Coupling device is coupled to described target pathway structure with described signal, to regulate in somatomedin generation relevant with the effectiveness that strengthens described activating agent and the cytokine generation at least one.

28. electromagnetic treatment apparatus as claimed in claim 27, wherein said somatomedin comprise in fibroblast growth factor, platelet derived growth factor, interleukin somatomedin and the bone morphogenetic protein somatomedin at least one.

29. electromagnetic treatment apparatus as claimed in claim 20, wherein said Coupling device is coupled to described target pathway structure with described signal, to regulate angiogenesis and neovascularization, strengthens the effectiveness of described activating agent.

30. electromagnetic treatment apparatus as claimed in claim 20, wherein said Coupling device is coupled to described target pathway structure with described signal, with the generation of mediator's somatomedin, strengthens the effectiveness of described activating agent.

31. electromagnetic treatment apparatus as claimed in claim 20, wherein said Coupling device is coupled to described target pathway structure with described signal, to increase cell and tissue activity, strengthens the effectiveness of described activating agent.

32. electromagnetic treatment apparatus as claimed in claim 20, wherein said Coupling device is coupled to described target pathway structure with described signal, to increase cell mass, strengthens the effectiveness of described activating agent.

33. electromagnetic treatment apparatus as claimed in claim 20, wherein said Waveform generating apparatus, connecting device and Coupling device are configured to light-duty and portative.

34. electromagnetic treatment apparatus as claimed in claim 20, wherein said Waveform generating apparatus, connecting device and Coupling device merge in mattress, mattress cushion, bed and the positioning equipment at least one.

35. comprising, electromagnetic treatment apparatus as claimed in claim 34, wherein said positioning equipment dissect in support, dissection wrappage and the medicated clothing at least one.

36. electromagnetic treatment apparatus as claimed in claim 35, wherein said medicated clothing comprise in clothes, fashion accessory and the footgear at least one.

37. electromagnetic treatment apparatus as claimed in claim 20, wherein said Waveform generating apparatus is programmable.

38. electromagnetic treatment apparatus as claimed in claim 20, wherein said Waveform generating apparatus transmit at least one pulsed magnetic signal during preset time.

39. electromagnetic treatment apparatus as claimed in claim 20, wherein said Waveform generating apparatus transmits at least one pulsed magnetic signal at time durations at random.

40. electromagnetic treatment apparatus as claimed in claim 20, it further comprises the transfer device that is used for the standard physical Therapeutic Method.

41. electromagnetic treatment apparatus as claimed in claim 40, wherein said standard physical Therapeutic Method comprise in heating, cooling, massage and the exercise at least one.

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