CN101502457A - Animal corneal contact lens for observing ocular fundus and assisting operation under microscope - Google Patents
Animal corneal contact lens for observing ocular fundus and assisting operation under microscope Download PDFInfo
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- CN101502457A CN101502457A CNA2009100679806A CN200910067980A CN101502457A CN 101502457 A CN101502457 A CN 101502457A CN A2009100679806 A CNA2009100679806 A CN A2009100679806A CN 200910067980 A CN200910067980 A CN 200910067980A CN 101502457 A CN101502457 A CN 101502457A
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Abstract
The invention discloses a corneal contact lens used for microscopically observing fundus and assisting with operation, comprising a cylinder-shaped lens body; both ends of the lens body are respectively provided with a corneal contact surface and a corneal optical surface. The diameter beta of the lens body is more than or equal to 5mm and less than or equal to 15mm and the height gamma of the lens body is more than or equal to 1.5mm and less than or equal to 7.5mm; the corneal contact surface has a smooth surface and blunt round edges; the shape of the corneal contact surface is an inner concave approximately matched with the outward-convex shape of the cornea; the curvature alpha of the inner concave is slightly larger than the corneal curvature of the experimental animal and is more than or equal to 2mm and less than or equal to 9mm; the optical surface is a smooth plane or incline; when the optical surface is an incline, the included angle delta between the incline and the plane is more than or equal to 0 degree and less than or equal to 60 degrees; the lens body is made of fiber plastics or glasses. The invention has the advantages of having simple structure, easy operation and stable imaging, having no damage to cornea, being suitable for cornea with various diameters and curvatures and making obvious progress in using two hands to carry out entoptic operations such as vitrectomy and retinal operation, etc.
Description
Technical field
The present invention relates to the corneal contact lens that a kind of medical experiment is used, in particular, the present invention relates to a kind of animal corneal contact lens that microscopically is observed the optical fundus and assisted vitrectomy that is used for.
Background technology
As everyone knows, retinopathy such as detachment of retina, diabetic renal papillary necrosis, the retinal vein occlusion all can have a strong impact on vision, even cause losing one's sight.At present,, just extensively be carried out in (as rat, mice, rabbit, cat, dog, pig, monkey etc.) in the zoopery, to inquire into the curative effect of disease mechanisms, the new treatment method of observation at a large amount of research work of these diseases.Wherein, operation is the most basic a kind of method at the bottom of the animal eye under the operating microscope, and the variation of record optical fundus is a most important scientific research evidence under the direct-view.But, since animal eyeball itself be high hypermetropia state (as the about 78D of rat, the about 62D of rabbit) considerably beyond researcher merely by microscopical observation ability, so, need just can see the optical fundus clearly in conjunction with other means.
Contemporary ophthalmology studies show that: eyeball is actually the optical instrument of being made up of the refracting media of various different flexion rates, particularly, described refracting media is meant cornea, aqueous humor, crystal and vitreous body, in these refracting medias, the flexion rate accounts for 70～80% cornea and plays main effect, so,, just can reach the target that microscopically is observed the optical fundus and carried out the optical fundus operation as long as solved the flexion rate problem of cornea.
At present, the usual method that solves foregoing problems is: researcher one hand-held plane slide, at microscopically compressing cornea, so that see clearly at the bottom of the animal eye, another hands carries out operations such as intravitreal injection or subretinal injection.Though the method can reach certain effect, have three problems: one, level of compression are limited by the experience and the muscle power of researcher, and long-time compressing can make the imaging effect instability; Its two, singlehanded ophthalmic processing ease is made a fault; Its three, described compressing method often causes the damage of corneal epithelium and corneal stroma elasticity is changed, and is of long duration, also can cause corneal edema, thus influence further observation subsequently.
For this reason, part Study person's corneal contact lens of once attempting being used for human eye is attached at the cornea of animal (as rat, mice, rabbit, cat, dog, pig, monkey etc.).Like this, though can see the optical fundus clearly at microscopically, and obtained the marked improvement of both hands ophthalmic operation, but because the kind difference of animal, it is very big that its corneal diameter and curvature differ, contact shakiness when causing examination of ocular fundus, and the optical effect of peripheral part is also poor.
Summary of the invention
Purpose of the present invention exactly for solving the problems of the technologies described above, provides a kind of simple in structure, easy and simple to handle, imaging is stable, the corneal not damaged, and be suitable for the animal corneal contact lens that microscopically is observed the optical fundus and assisted vitrectomy that is used for of various diameters and curvature cornea.
Technical scheme of the present invention is: a kind of microscopically that is used for is observed optical fundus and the animal corneal contact lens of assisting vitrectomy, and its formation comprises cylindric mirror body, and the two ends of described mirror body are provided with cornea contact surface and optical surface respectively.
The diameter of described mirror body is 5mm≤β≤15mm; The height of described mirror body is 1.5mm≤γ≤7.5mm;
Described cornea contact surface has smooth surface and blunt rounded edge, and it is shaped as the inner concave that the convex shape with animal corneal matches, and the curvature of described inner concave is slightly larger than the corneal curvature of experimental animal, and its curvature range is 2mm≤α≤9mm.
Described optical surface is slick plane or inclined-plane;
When described optical surface was the inclined-plane, the angle of itself and horizontal plane was 0 °≤δ≤60 °;
When described optical surface was the inclined-plane, the optimum angle of itself and horizontal plane was 30 °.
The present invention is used for the animal corneal contact lens that microscopically is observed optical fundus and assisting operation, has following beneficial effect than prior art:
(1) all can be equipped with the curvature and the corresponding contact lens of diameter of a cover and its cornea for the laboratory animal of different genera, and be attached to the cornea face of laboratory animal by couplant, the two is integrated, form a complex optics, the diopter of laboratory animal cornea had both neutralized, the instability that has reduced diameter between contact lens and the cornea, curvature difference again to greatest extent and brought is disturbed, and has overcome prior art and has adopted compressing cornea mode to be limited by the experience and the muscle power of researcher and make the unsettled defective of imaging effect;
(2) illumination by microscope and secondary light source, convenient direct-view down to the optical fundus situation observe, record, and obtain both hands and carry out marked improvement such as ophthalmic such as operation on vitreous or operation on retina operations, cooperate the sight glass of different angles to use instead, overcome prior art because animal species is different and differ the defective that contacts shakiness and peripheral part optical effect difference that is greatly caused with animal corneal diameter and curvature;
(3) the selection of material light weight, robustness is good, heat-resisting, heat-resisting, acid and alkali-resistance, long service life, safe, noinvasive is painless, and applicable object is not limited by animal varieties restriction and animal age, and can not change the organizational structure and the physiological status of animal corneal.
Description of drawings
Fig. 1 is an oblique mirror structural representation of the present invention;
Fig. 2 is a flat mirror structural representation of the present invention.
The specific embodiment
For the easier quilt of content of the present invention is clearly understood, technical scheme of the present invention is done to describe in detail below in conjunction with accompanying drawing and preferred embodiment.
The present invention is used for the animal corneal contact lens that microscopically is observed optical fundus and assisting operation, be the characteristics of utilizing cornea in refraction of eye, can play a major role, Yan Zhi the different corneal curvatures that are suitable for various laboratory animals and the sight glass of different corneal diameters voluntarily, this corneal contact lens can contact with the cornea face of laboratory animal by couplant, be convenient to examine under a microscope, the optical fundus situation of recording laboratory animal, and assist to carry out operation on vitreous and operation on retina.
With reference to Fig. 1, Fig. 2, the present invention is used for the animal corneal contact lens that microscopically is observed optical fundus and assisting operation, and its formation comprises mirror body 200, and the two ends of described mirror body 200 are provided with cornea contact surface 100 and optical surface 300 respectively.
Described mirror body 200 is cylindric, and its diameter range is 5mm≤β≤15mm, and its altitude range is 1.5mm≤γ≤7.5mm, and its function is importing into of light and exports.
The blunt rounded edge that described cornea contact surface 100 has the smooth surface of the light transmission of being beneficial to and can avoid scratching the angle conjunctiva, it is shaped as the inner concave that closely coincide with the convex shape of animal corneal, the curvature of described inner concave is slightly larger than the corneal curvature of experimental animal, its curvature range is 2mm≤α≤9mm, the purpose that this curvature is set is: the inner concave of described cornea contact surface 100 can be combined closely in the canthus of different experiments animal face after applying couplant, and the tortuosity ratio of its cornea that neutralizes, play the effect of supporting the mirror body simultaneously.
Described optical surface 300 is slick plane or inclined-plane, with reference to Fig. 1, the optical surface 300 on inclined-plane and the angular range of horizontal plane are 0 °≤δ≤60 °, being provided with in the scope of this angle, angle is big more, then microscopically is observed the animal eye fundus image the closer to periphery, and preferable angle Selection is δ=30 °; With reference to Fig. 2, parallel with horizontal plane, the such setting of planar optical surface 300 does not need to oppress especially the animal eyeball sclera, and, can also observe different parts at the bottom of the animal eye by the corneal contact lens of using different angles instead.The angle that experiment showed, described corneal contact lens is big more, and the observing effect at the bottom of the periphery hole is good more.
Described mirror body 200, cornea contact surface 100 and optical surface 300, currently used material is compo or glass, the two is compared, compo light weight and hardness is big, suction is few, and the mirror body is thin, stability after laying on the cornea is better than glass, and still, its optical property is poor than glass.Along with the development of material science, can use better material and make this corneal contact lens.
Corneal contact lens of the present invention, can make in groups and use according to the different sizes of different animals eyeball and different curvature, in order to obtain best observing effect, it is the corneal contact lens of smooth ramp that the present invention is at least every kind of animal corneal contact lens and 1 to 2 optical surface that to have prepared 1 optical surface be smooth flat.
Using method of the present invention is such:
(1) according to animal species, select diameter, curvature corneal contact lens correspondingly, the optical surface 300 of this corneal contact lens is slick plane;
(2) on the cornea contact surface 100 of aforementioned corneal contact lens, drip two couplants, and its button is put in the centre of animal corneal;
(3) at microscopically, utilize the illumination of microscope light source or other secondary light sources, observe central part at the bottom of the animal eye by eyepiece by optical surface 300;
(4) use instead at the bottom of the periphery hole of optical surface 300 for the corneal contact lens observation animal of smooth ramp, the optical surface 300 of this corneal contact lens is 30 ° with the angle of horizontal plane, in the time of necessary, the angle that also can use its optical surface 300 and horizontal plane instead is 40 °～60 ° a corneal contact lens, with till the most clearly seeing the optical fundus target clearly.
Experimental results demonstrate, the present invention is used for the animal corneal contact lens that microscopically is observed optical fundus and assisting operation, can clear, effective observation, the optical fundus situations of animals such as record rat, mice, rabbit, pig, dog, monkey, simple to operation, image is clear stable, demonstration can be from line operate a little, and to the eyes not damaged of animal.Intraocular surgery if desired can also bimanualness, has solved the problem that the singlehanded ophthalmic processing ease of prior art is made a fault.
Above is that schematically embodiment wherein also only is for example of the present invention clearly is described, is not the qualification to its embodiment with reference to accompanying drawing to the description of technical solution of the present invention.Those of ordinary skill in the field should be appreciated that, under the enlightenment of above-mentioned explanation, other staff can also make all multi-form variations or change to it, or according to the difference of laboratory animal or difference the material of described contact lens, curvature, mirror height degree, diameter, inclined-plane angle etc. are made being equal to his and replacing of corresponding modify or other settings.Special needs to be pointed out is that only otherwise break away from design aim of the present invention, any conspicuous change that anyone made and have the similar Design that is equal to replacement all is included within protection scope of the present invention.
Claims (9)
1. one kind is used for the animal corneal contact lens that microscopically is observed optical fundus and assisting operation, comprises cylindric mirror body, it is characterized in that the two ends of described mirror body are respectively arranged with cornea contact surface and optical surface.
2. the animal corneal contact lens that is used for microscopically observation optical fundus and assisting operation according to claim 1 is characterized in that the diameter of described mirror body is 5mm≤β≤15mm.
3. the animal corneal contact lens that is used for microscopically observation optical fundus and assisting operation according to claim 1 is characterized in that the height of described mirror body is 1.5mm≤γ≤7.5mm.
4. the animal corneal contact lens that is used for microscopically observation optical fundus and assisting operation according to claim 1, it is characterized in that, described cornea contact surface has smooth surface and blunt rounded edge, it is shaped as the inner concave that closely coincide with the convex shape of animal corneal, and the curvature of described inner concave is slightly larger than the corneal curvature of experimental animal.
5. the animal corneal contact lens that is used for microscopically observation optical fundus and assisting operation according to claim 4 is characterized in that the curvature range of described cornea contact surface is 2mm≤α≤9mm.
6. the animal corneal contact lens that is used for microscopically observation optical fundus and assisting operation according to claim 1 is characterized in that described optical surface is slick plane or inclined-plane.
7. according to claim 6ly be used for the animal corneal contact lens that microscopically is observed optical fundus and assisting operation, it is characterized in that, when described optical surface was the inclined-plane, the angle of itself and horizontal plane was 0 °≤δ≤60 °.
8. according to claim 6ly be used for the animal corneal contact lens that microscopically is observed optical fundus and assisting operation, it is characterized in that, when described optical surface was the inclined-plane, the angle of itself and horizontal plane was 30 °.
9. the animal corneal contact lens that is used for microscopically observation optical fundus and assisting operation according to claim 1 is characterized in that the making material of described mirror body, cornea contact surface and optical surface is compo or glass.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009100679806A CN101502457A (en) | 2009-02-27 | 2009-02-27 | Animal corneal contact lens for observing ocular fundus and assisting operation under microscope |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2009100679806A CN101502457A (en) | 2009-02-27 | 2009-02-27 | Animal corneal contact lens for observing ocular fundus and assisting operation under microscope |
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| CN101502457A true CN101502457A (en) | 2009-08-12 |
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| CNA2009100679806A Pending CN101502457A (en) | 2009-02-27 | 2009-02-27 | Animal corneal contact lens for observing ocular fundus and assisting operation under microscope |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389289A (en) * | 2011-06-30 | 2012-03-28 | 孙晓东 | Handheld experimental animal corneal contact lens |
| CN103211576A (en) * | 2013-04-22 | 2013-07-24 | 江苏省人民医院 | Wide-angle optical imaging system for mouse retina optical coherence tomography (OCT) inspecting and inspecting method with wide-angle optical imaging system |
| CN104173022A (en) * | 2014-09-05 | 2014-12-03 | 何明光 | Corneal contact lens and method for assisting mouse fundus observation with microscope |
| CN104375282A (en) * | 2014-10-22 | 2015-02-25 | 南京医科大学第一附属医院 | Cornea contact lens for vitreous retina operation |
-
2009
- 2009-02-27 CN CNA2009100679806A patent/CN101502457A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389289A (en) * | 2011-06-30 | 2012-03-28 | 孙晓东 | Handheld experimental animal corneal contact lens |
| CN103211576A (en) * | 2013-04-22 | 2013-07-24 | 江苏省人民医院 | Wide-angle optical imaging system for mouse retina optical coherence tomography (OCT) inspecting and inspecting method with wide-angle optical imaging system |
| CN104173022A (en) * | 2014-09-05 | 2014-12-03 | 何明光 | Corneal contact lens and method for assisting mouse fundus observation with microscope |
| CN104375282A (en) * | 2014-10-22 | 2015-02-25 | 南京医科大学第一附属医院 | Cornea contact lens for vitreous retina operation |
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Open date: 20090812 |