CN101500652A - Therapy apparatus with sequential functioning - Google Patents
Therapy apparatus with sequential functioning Download PDFInfo
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- CN101500652A CN101500652A CNA2007800254383A CN200780025438A CN101500652A CN 101500652 A CN101500652 A CN 101500652A CN A2007800254383 A CNA2007800254383 A CN A2007800254383A CN 200780025438 A CN200780025438 A CN 200780025438A CN 101500652 A CN101500652 A CN 101500652A
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- ultrasonic transmitter
- ultrasonic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0056—Beam shaping elements
- A61N2007/0065—Concave transducers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0078—Ultrasound therapy with multiple treatment transducers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0086—Beam steering
- A61N2007/0095—Beam steering by modifying an excitation signal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
- A61N2007/027—Localised ultrasound hyperthermia with multiple foci created simultaneously
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- General Health & Medical Sciences (AREA)
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Abstract
The invention relates to a treating apparatus for treating tissues by emitting a focused ultrasound. The apparatus (I) has a therapy probe (1) with a transducer (2) formed by ultrasound emitters (3) distributed in categories N1 to NM on a high intensity focused ultrasound emission face (8) which is a revolution surface generated by rotation of a curve segment around an symmetry axis. The categories define independent and contiguous focal volumes. A control circuit (7) has a signal generator for independently, alternately and consecutively activating the categories of the emitters to ensure continuous insonification according to a crown derived from different categories.
Description
Technical field
The present invention relates to the technical field of high intensity focused ultrasound (HIFU), relate more specifically to utilize the metacheirisis (trerapeutic treatment) of described focus supersonic.
Background technology
Known when utilizing focused ultrasound therapy, because the combination of heat effect and air pocket (acousticcavitation) phenomenon can cause damage biology to tissue.The shape of these tissue injurys is directly from the section of applied ultrasonic field.Therefore, for example under the situation of spherical sensors, tissue injury is the ellipse that is centered close on the focus substantially.
In some applications, need to form crown tissue injury.For example, thereby crown tissue injury can surround tumor it is isolated on the blood vessel plane, thereby cause tumor necrosis.Similarly, crown damage can be formed at the periphery of the vein or the tremulous pulse of organ joint.
What prior art had proposed multiple employing focus supersonic is the treatment probe of purpose to obtain crown damage biology.
Described therapy equipment among the file US 20,06/,009 753, wherein the treatment probe of this therapy equipment comprises the cylinder shape sensor by conical focusing mirror ultrasonic emitting.This therapy equipment is difficult for making.In addition, the focusing that obtains by reflecting mirror is effective not as the focusing that directly obtains from the geometry of pick off.
Similarly, the document among nuclear magnetic resonance (Magnetic Resonance Imaging) the periodical file 12:571-583 (delivering in 2000) " utilize shake the supersonic local hyperthermia of focusing under the radiography guiding of magnetic: the helical trajectory of the well-balanced property of the optimized temperature of focus in the target area "
(Local hyperthermia with MR-guided focused ultrasound:Spiraltrajectory of the focal point-optimized temperature uniformity in the targetregion) described the therapy equipment of the multicomponent pick off that comprises the spherical geometry body.The document has been described along helical trajectory (approaching crown in this sense) and has been created one group of damage biology, and body to be destroyed (for example tumor) is surrounded.Adopt the purpose of this path to be in body to be destroyed, to obtain more uniform thermal-neutron dose.Yet described device has only by arranged side by side on the repetition of unit damage and the space could form crown damage biology.
Patent application EP 0 421 290 has described a kind of spherical sensors, wherein feels at ease and has put the horizontal stationary district.The effect of this structure is to revise hyperacoustic focusing profile, enough greatly the time, obtains conical focus piece at the diameter of described horizontal stationary surface, and wherein maximum pressure concentrates on the axis of symmetry of pick off usually, and does not label in the periphery.
In order to address this problem, patent application EP 0 421 290 proposes geometrically that spheric pick off is cut into several parts that are separated from each other or rotate to an angle, thereby with focus separately and be placed on position with a certain distance from the axis of symmetry of pick off.Obviously, this frame for movement is difficult to relatively realize, and is difficult to control.In addition, for each structure, the quantity of focus and position are fixed, have considerably limited the probability of handling.
In a word, it should be noted that usually and can form the annular focus piece, because the size of each ultrasonic component is less than half-wavelength from the multicomponent spherical sensors.Because wavelength is very little with respect to the size of pick off, if do not adopt a large amount of ultrasonic components and and these a large amount of ultrasonic component corresponding techniques problem and costs, this solution can not be used in practice.
In order to compensate, must consider that the body of being treated depends on different parameters, specifically comprise time and space interval between time of exposure and the ultrasound emission.When these parameters were correctly defined, handled volume was launched the focus area restriction of face, makes this technology only use as invasive surgical operation means.
In order to treat bigger body, the known moving focal point zone of answering.First kind of technology is included in mechanically mobile ultrasonic transmitter between each ultrasound exposure.Thereby second kind of known technology comprises by postponing rule excitation-emission device moving focal point zone electronically.
At present, must consider, mainly be to utilize the termination period between the ultrasound exposure to control by focused ultrasound therapy so far, thereby make tissue and ultrasonic transmitter cooling.This has caused treatment time relatively significantly to increase.In addition, cavitation and reheat effect (thermalreheating activity) can't keep in area for treatment in the termination period, and this has weakened the effect of treatment.
In prior art, the emission of implementation continuous ultrasound has been proposed, wherein ultrasonic transmitter and intermediate structure are activated continuously, cause ultrasonic transmitter to damage and organize incendiary danger, for example damage of the junction surface outside the target area or shallow burn.
Summary of the invention
The objective of the invention is to correct the shortcoming of prior art by proposing new therapy equipment, wherein said therapy equipment be designed to according to crown and/or in by the focus body of crown distribution concentration ultrasonic, the quantity of focus body and position can be regulated simply, are not restricted to the function of tissue injury to be produced.This device operate in the continuous heating that keeps in the treatment region tissue, protect the tissue on the acoustic path of being positioned at outside treatment region simultaneously.
For reaching this purpose, the objective of the invention is to propose a kind of therapy equipment of carrying out tissue treatment by the emission of concentration ultrasonic.
According to the present invention, this device comprises:
-comprise the probe of the pick off that constitutes by ultrasonic component, wherein ultrasonic component is distributed in several apoplexy due to endogenous wind of the surface of emission of concentration ultrasonic, the surface of emission is the surface of revolution that constitutes by around the pulsating rotation of the curve of axis of symmetry, and the class of ultrasonic component independently defines and fully close focus body.
-and the control circuit that comprises signal generator, wherein signal generator controlledly be used for independently, the class of excitation ultrasound emitter alternately and fully continuously, thereby guarantee to carry out insonify continuously according to crown from different ultrasonic transmitter apoplexy due to endogenous wind.
According to preferred embodiment, ultrasonic component is distributed on the surface of emission of concentration ultrasonic, this surface of emission has by the recessed of given length or convex curve segment around the rotation of axis of symmetry and the surface of revolution that constitutes, the center of curve of wherein said curve segment is positioned at the position that certain distance is arranged apart from axis of symmetry, wherein R ≠ 0.
According to preferred alternate embodiment, this surface of revolution is by given length, given radius and be centered close to apart from the circular arc segment of axis of symmetry certain distance and constitute, wherein this distance ≠ 0.
According to the embodiment of another variation, the radius of the distance of axis of symmetry less than this circular arc arrived at the pulsating center of circular arc.
Advantageously, this surface of revolution therein heart region deviding be centered close to axis of symmetry and be suitable for receiving the opening of image sensor.
According to the favorable characteristics of theme of the present invention, the class of ultrasonic transmitter is corresponding to concentric ring, or radiate fan-shaped, or the radiation group of ultrasonic transmitter.
According to first alternate embodiment, ultrasonic transmitter distributes according to concentric ring, and wherein control circuit comprises signal generator, this signal generator is guaranteed to move delay or the phase rule that focuses on hat according to focal axis according to being used for, thus controlled be used for transmitting activate ultrasonic transmitter on each described concentric ring.
According to another embodiment, ultrasonic transmitter be distributed on the radiation fan-shaped in, wherein control circuit comprises signal generator, this signal generator is according to the delay or the phase rule that move that are used for guaranteeing to focus on hat, thus controlled be used for transmitting activate the ultrasonic transmitter of each described radiation on fan-shaped.
According to preferred alternate embodiment, this ultrasonic transmitter is distributed on and is divided in the segmental concentric ring of radiation, and control circuit comprises signal generator, this signal generator is according to the delay or the phase rule that move that are used for guaranteeing to focus on hat, thus controlled be used for transmitting activate the ultrasonic transmitter of each described radiation on fan-shaped.
Advantageously, the radiation of ultrasonic transmitter is fan-shaped to be combined and to constitute the radiation group, and wherein control circuit comprises signal generator, thus this signal generator controlled be used for transmitting activate ultrasonic transmitter in each described radiation group.
Control circuit preferably includes signal generator, and this signal generator is according to postponing or phase rule is controlled as each radiation group and transmits, thereby activates the ultrasonic transmitter in each radiation group.
Advantageously, control circuit comprises signal generator, and this signal generator is controlled to transmit, thereby activates the ultrasonic transmitter class of ring corresponding to ultrasonic transmitter, fan-shaped or radiation group according to the order that changes or periodically repeat.
Control circuit preferably includes signal generator, thereby be used for the transmitting set of the class that activates ultrasonic transmitter that this signal generator is controlled, the set of wherein said class is made of different ultrasonic transmitter classes, or has the class of some common ground to constitute with this set at least.
Other themes of the present invention focus on the quantity of the binding cable that reduces ultrasonic transmitter.For this reason, the radiation group that constitutes the set of same ultrasonic transmitter and control circuit is connected to ultrasonic transmitter by coaxial cable.Wherein on the one hand, the center of all ultrasonic transmitters of colleague mutually of different radiation groups is joined together, on the other hand, the ground (grounds) of all ultrasonic emission devices of identical radiation group is by interconnection, the signal that is used for activating the ultrasonic emission device is converted to ultrasonic energy by the ultrasonic transmitter that radiation is organized separately, and wherein the ground cover of ultrasonic transmitter reason is connected to the ground of activation signal.
Description of drawings
Various other features will appear in the description below with reference to accompanying drawing, and wherein accompanying drawing provides the embodiment of theme of the present invention by non-restrictive example.
Fig. 1 is the view according to therapy equipment of the present invention.
Fig. 2 to 4 is half views according to the alternate embodiment of the probe of the part of formation therapy equipment of the present invention.
Fig. 5 to 7 is the partial views that comprise the different ingredients of the ultrasonic transmitter that constitutes the part for the treatment of probe.
Fig. 8 A to 8C shows the sequential chart according to the activation rule of the time function of the ultrasonic transmitter as therapy equipment of the present invention.
Fig. 8 D shows the treatment along with the time that is obtained at treatment region by therapy equipment according to of the present invention.
Fig. 9 shows the view of the preferred linking rule of ultrasonic transmitter.
The specific embodiment
Can draw more expressly from Fig. 1, theme of the present invention relates to therapy equipment I in general sense, and it comprises be used for the treatment probe 1 for the treatment of by high intensity focused ultrasound (HIFU) on biological tissue.This treatment probe 1 is particularly including the pick off 2 with one or more ultrasonic transmitters 3, for example piezoelectric element.These ultrasonic transmitters 3 are connected to control circuit 7 by coaxial cable 5 by amplifier stage 6, the activation ultrasonic transmitter 3 thereby control circuit 7 transmits.Control circuit 7 does not describe in further detail, because its manufacturing is very familiar for art technology person.Therefore, control circuit 7 comprises controlled signal generator as a rule, and this signal generator is connected to ultrasonic transmitter by amplifier stage 6.
Pick off 2 has the surface of emission 8 of concentration ultrasonic.The preferred exemplary embodiment of more specifically describing according to Fig. 2, this surface of emission 8 is around the rotation of axis of symmetry S and the surface of revolution that forms by the segment of recessed or convex curve 9, wherein curve 9 length are that I, center of curve C are positioned at apart from axis of symmetry S distance and are the position of R, and wherein R is not 0.
According to the first advantageous variant embodiment shown in Figure 2, surface of revolution 9 by length be 1, radius be that r, center c be positioned at apart from axis of symmetry S distance is that the segment of circular arc of the position of R forms, wherein R is not 0.The geometry of this surface of revolution 9 can be considered to toroid.
According to preferred alternate embodiment shown in Figure 3, surface of revolution 9 is that to be I, its center C form apart from the distance R of the axis of symmetry S segment less than the circular arc of radius r for C, length by the center.Can think that this geometry is so-called crossed loops.For example, the pulsating length I of circular arc can be less than π r/2.
Fig. 3 more clearly illustrates, surface of revolution 9 therein the heart area limiting opening 11, opening 11 be centered close to axis of symmetry S and diameter is for example 2R.Advantageously, this opening 11 is used to receive imageing sensor.
According to the exemplary embodiment shown in Fig. 2 and 3, surface of revolution 9 is made of the segment of concavity towards the annulus axle of axis of symmetry S.Certainly, surface of revolution 9 can be made of the concavity segment towards the circular arc of axis of symmetry S as shown in Figure 4.On this meaning, surface of revolution 9 can be formed by the curve segment that is different from circular arc.Therefore, surface of revolution 9 can be formed by the curve segment that apart from r have continuous changing value (do not have deformation point) of the pulsating every bit of curve to center of curve C, for example the elliptic curve segment.
According to above understanding, the surface of emission 8 of pick off has torus geometry.Usually, the shape of the surface of emission 8 of pick off is that described curve segment can have different shapes by the function of the curve segment geometry of rotating this ultrasound emission surface of formation around axis of symmetry.
According to another characteristic of the invention, ultrasonic transmitter 3 is placed on the surface of emission 8, thereby is distributed to different class N
1To N
MIn, each class definition point, road through, zone or general focus body or focus on body.According to hereinafter describing in detail, the focus body is independent and fully close.
Fig. 5 has described exemplary embodiment, and wherein ultrasonic transmitter 3 is distributed on from a
1To a
iConcentric ring on.Therefore pick off 2 according to the present invention is made of the loop network of i concentric ring, and each concentric ring is made of ultrasonic transmitter 3.The signal activation that does not have time-delay or phase rule of these ultrasonic transmitter 3 controlled circuit 7 emissions, thus guarantee that ultrasound wave is according to hat C
0Naturally focus on.Therefore, such arrangement is positioned at focal length F with respect to face 8 by focus being placed on the focusing of guaranteeing on the focal axis A according to hat naturally
0On.This focuses on hat C
0Radius be R
0
According to alternate embodiment, control circuit 7 sends signal in order to activate concentric ring a
1To a
iOn ultrasonic transmitter 3; Guaranteeing to focus on crown root by time-delay or phase rule moves according to focal axis A.Therefore control circuit 7 carries out dynamic electron and focuses on, thereby will be preced with focus from its natural place C
0Move to terminal position C
1With immediate position C
2Each focuses on hat C
1And C
2Difference is focal length F at interval
1And F
2, its radius is respectively R
1And R
2The tumor that this structure is suitable for treating different size and is arranged in the tissue different depth.
Fig. 6 has described another alternate embodiment of the geometric distribution of ultrasonic transmitter 3.In the embodiment shown in fig. 6, ultrasonic transmitter 3 is distributed on concentric ring a as shown in Figure 5
1To a
iIn, but also be split into the fan-shaped s of radiation
1To s
jIn other words, the plane that the surface of emission 8 of pick off is passed axis of symmetry S is cut apart, thereby it is fan-shaped to produce successive radiation.Being split into the annular and the pick off of radiation ultrasonic transmitter adopts the electron focusing method and focus is preced with from its natural place C
0Move to lateral attitude C
3And C
4Each focus hat C
0, C
3And C
4Between focal length F respectively at interval
0, F
3And F
4And separate with pick off, the diameter of each focus hat is respectively R
0, R
3And R
4Therefore this focusing hat is arranged in the last planar same level that is parallel to pick off, wherein goes up the plane perpendicular to axis of symmetry S.The combination that it should be noted that the electron focusing method that is used for Fig. 5 and structure shown in Figure 6 has been revised this plane with respect to planar angle of incidence on the pick off, but has also caused the hat according to toric distortion.This structure is applicable to the tumor treatment of different size.
It shall yet further be noted that Fig. 6 has described according to concentric ring a
1To a
i, be divided into the radiation fan-shaped s
1To s
jThe distribution of ultrasonic transmitter 3.Certainly, the surface of emission 8 that can suppose pick off comprises that a string is divided into the fan-shaped s of radiation
1To s
jUltrasonic transmitter 3.Advantageously, the segmental ultrasonic transmitter 3 of each described radiation is activated according to being used to guarantee to focus on hat mobile time-delay or phase rule by control circuit 7.
Fig. 7 has described another alternate embodiment, wherein the fan-shaped s of the radiation of ultrasonic transmitter
1To s
jBe combined and constitute radiation group G
1To G
kThe radiation group should mean the fan-shaped s of different radiation
1To s
jCombination, for example defined among the embodiment that Fig. 6 describes, thus ultrasonic transmitter 3 is distributed evenly at concentric ring a
1To a
iIn.The fan-shaped s of the radiation of pick off
1To s
jPreferably as one man made up, thereby formed consecutive identical group G
1To G
kIn the embodiment shown in fig. 7, each radiation group G
1To G
kComprise ten fan-shaped s of radiation
1To s
jIn addition, pick off comprises for example ten radiation group G
1To G
10, they all comprise the ultrasonic transmitter of equal number.In Fig. 7, radiation group G has only been described
1
Control circuit 7 is used for sending signal to the ultrasonic transmitter of radiation group, and is as indicated above.The ultrasonic transmitter of each radiation group is activated, thus with concentration of energy in single focus body.This focusing is corresponding to the described embodiment that utilizes spherical set even obtain by the group from torus geometry.Therefore can will be distributed in concentration of energy that focus labels to picture ultrasonic transmitter group G
1To G
kOn so much individual focal spots body E.Should concentrate and for example can on one or more specified points of tumor to be treated, concentrate and strengthen the tissue gangrene.Also can imagine and form several local foci road warps that focus is labeled that are distributed in simultaneously.
According to another feature of theme of the present invention, the signal generator of control circuit 7 is controlled to be used for independently, to activate alternately, fully continuously and encircle a
1To a
i, radiate fan-shaped s
1To s
j, or ultrasonic transmitter radiation group G
1To G
k, Fig. 5 and Fig. 6 are described as mentioned, thereby guarantee to send continuous insonify from ring, fan-shaped or different radiation group respectively.Must understand that theme of the present invention is to activate independently, alternately, fully continuously to be divided into several class N
1To N
mUltrasonic transmitter, each class associating or in conjunction with one or more ultrasonic transmitter concentric rings, or the radiation of one or more ultrasonic transmitter is fan-shaped, or one or more ultrasonic transmitter radiation group.
Can more clearly obtain N to 8C according to Fig. 8 A
1The ultrasonic transmitter of class is activated and realizes emission T
1At emission T
1Latter stage, N
1The ultrasonic transmitter of class no longer is activated, thereby makes ultrasonic transmitter and be positioned at N
1Intermediate structure between the class ultrasonic transmitter and focal zone cooling.At N
1Class emission T
1After finishing, N
2The class ultrasonic transmitter is activated, thereby finishes emission T in for example equal with first emission time period
2Emission T
2Make ultrasonic transmitter and N thereby be interrupted
2Intermediate structure between the class ultrasonic transmitter and focal zone cooling.Control circuit 7 continues N
1To N
mThe continuous activation of class ultrasonic transmitter.N
1To N
mTherefore the class ultrasonic transmitter is activated one by one, thus respectively differ from one another and the successive substantially focusing body in position in finish emission T
1-T
Km+1...; T
2-T
Km+2..., K=1 wherein, 2....
Opposite with the dynamic focusing method, consider that the ultrasonic transmitter of certain class is activated independently and fully continuously by another kind of ultrasonic transmitter.According to above can obviously finding out N
1To N
mThe ultrasonic transmitter of class is alternately activated, continuously or one by one promptly.In the more detailed description, activate N hereinafter according to variable or immutable order or definite order
1To N
mThe class ultrasonic transmitter.
Favourable and ideally, N
2Class ultrasound emission T
2And then N
1The ultrasound emission T of class
1Realize not having to postpone or shift to an earlier date.In practice, thus must consider that control circuit 7 fully activates all kinds of ultrasonic transmitters continuously and guarantees sustained sound irradiation in the focal zone.In fact, interruption or recovery between the verified insonify of adopting can actually cause launching.If emission T
1End and the emission T
2Beginning between time-delay be not enough to lose the cavitation effect of emission of front and the benefit of heating effect, N
2The emission T of class
2With N
1The emission T of class
1Can be considered to fully continuously.Similarly, can not produce tissue burning, two emission T if the recovery time between these emissions is enough short
1And T
2Can be considered to fully continuously.
Can find out obviously that by Fig. 8 D treatment region is successively by N
1To N
mClass is insonify continuously.Therefore ultrasonic therapeutic is carried out continuously and can not oppressed identical ultrasonic transmitter.Time between two ultrasound emission is 0 or fully little, makes air pocket and heating effect remain on the level of treatment region.Therefore each ultrasound emission is benefited from the intensification of the emission of front and bubble velocity immediately, and need not construct them again between two emissions.This technology has increased on the volume of each damage relevant with the ultrasonic transmitter of each class and/or the certain degree and has reduced treatment time.
Ultrasonic transmitter is distributed at different apoplexy due to endogenous wind, can provide this body of destruction necessary thermal-neutron dose continuously from the continuous activated inhomogeneity of several quilts in identical focus body, wherein a class be independent of and abundant the focus body.
Therefore can treat the damage of large volume continuously, and not need in each ultrasound emission, to oppress components identical.Comprise in each class under the situation of several ultrasonic transmitters, this treatment principle can be combined with electron focusing, as indicated above.Every then class ultrasonic transmitter is activated according to time-delay or phase rule, thereby the electromigration of guaranteeing treatment region is moving.Must understand that described time-delay or phase rule provide for the ultrasonic transmitter that belongs to same item separately.In other words, there is not electron focusing between the inhomogeneity.Certainly, to move be practicable to the machinery of guaranteeing ultrasonic transmitter.
Although the target area is continued heating, the tissue between ultrasonic transmitter and the treatment region only receives ultrasonic successively, and this makes them be cooled off.In fact, when every class ultrasonic transmitter was activated, the acoustics road was exposed to the ultrasonic of each class emission separately through last tissue.In addition, reheating every class ultrasonic transmitter is controlled by its activation continuously.Certain class ultrasonic transmitter is cooled in the process that next class is activated.
Ultrasonic transmitter can activate by distinct methods.Therefore, control circuit 7 can send signal according to the order that periodically repeats and activate all kinds of ultrasonic transmitters.For example, N
1, N
2, N
3, N
4Class is activated one by one, this activation sequence N
1, N
2, N
3, N
4Repeat in time.
Nature can provide time dependent activation sequence.For example first the order in, N
1To N
4Class is pressed N
1To N
4Order activate continuously, and in the order below, the class order of face: the N that is pressed
1, N
3, N
2, N
4Activated continuously.
According to another possible variation, thereby control circuit 7 sends the set that signal activates the class of the ultrasonic transmitter that comprises different ultrasonic transmitter classes.Therefore, can be to class N for example
1-N
2, N
3-N
4Carry out successive group of activation.In other words, the ultrasonic transmitter of N1 and N2 class is activated continuously, is the N3-N4 class then.Group activates and can periodically carry out (N continuously
1-N
2, N
3-N
4, N
1-N
2, N
3-N
4...), or make following form, for example (N into
1-N
2, N
3-N
4, N
1-N
4, N
2-N
3...).
According to another alternate embodiment, thereby control circuit 7 sends the set that signal activates the class of the ultrasonic transmitter that comprises class, and wherein at least some classes are identical with respect to all set.Such variation is comprised that advantageously the pick off of a large amount of class Ni adopts.Therefore can realize class N
1-N
2-N
3-N
4Group activate, be class N then
4-N
5-N
6-N
7, be group N then
7-N
8-N
9-N
10, or the like.According to this example, 25% class recovery is arranged.Recovering the surface must be fully little, thus the burning that in launching continuously, does not produce the tissue between the ultrasonic transmitter of recovery district and focal zone.
Theme of the present invention specifically advantageously is applied in all treatments that utilize focus supersonic the particularly treatment of carcinoma of prostate and hepatocarcinoma.
According to another favorable characteristics, theme purpose of the present invention is to reduce the quantity of the coaxial connection cord between ultrasonic transmitter 3 and the control circuit 7.In order to reduce the quantity of cable, propose to carry out the switching electrically of ultrasonic transmitter 3, thereby fully reduce the quantity of necessary coaxial cable, and the needs of control electronic device (signal generator and power amplifier).
Fig. 9 more clearly provides, and this principle is used for equably and as one man ultrasonic transmitter is distributed in radiation group G
1To G
KSo each radiation group G
1To G
KThe ultrasonic transmitter 3 that comprises equal number i.All ultrasonic transmitters that label is identical in each radiation group are identical, and the center 100 of the coaxial cable of all ultrasonic transmitters of colleague all connects together mutually.The ground 101 of the coaxial cable of all the sensors of identical radiation group links together.Many ground as the radiation group are arranged here.The ground 103 of obsolete radiation group is free of attachment to the ground 104 of the activation signal that sends into control circuit 7 during ultrasound emission.The ground that activates the radiation group is connected to the ground 104 of activation signal.Therefore the activation signal of ultrasonic transmitter only is converted to acoustic energy for the pick off that its ground cover is managed the radiation group on the ground that is connected to activation signal.Ground can utilize the MUX 105 of order 106 controls by control circuit 7 to realize to the switching on another ground.For example, for comprising 256 pick offs that are evenly distributed on the ultrasonic transmitter of 8 radiation groups, each pick off need use a coaxial cable usually, therefore connects 257 lines.Because by the communication protocol on ground, the quantity of cable is 40 lines.
The present invention is not limited to described embodiment, can do the various variations that do not exceed the scope of the invention.
Claims (13)
1, come the therapy equipment of treated tissue by the emission of concentration ultrasonic, it is characterized in that comprising:
-probe (1), it comprises by the several class (N that are distributed on the surface of emission (8) that is positioned at concentration ultrasonic
1To N
M) in the pick off (2) that constitutes of ultrasonic component (3), the wherein said surface of emission (8) is the surface of revolution that is made of around the rotation of axis of symmetry the curve segment, the class of ultrasonic component independently define and abundant close focus body,
-and control circuit (7), it comprises and controlledly is used for independently, alternately and fully encourage the signal generator of the class of ultrasonic transmitter continuously, thereby guarantees to carry out the lasting light irradiation according to the hat that the class of different ultrasonic transmitters is formed.
2, therapy equipment according to claim 1, it is characterized in that described ultrasonic component is distributed on the surface of emission of concentration ultrasonic (8), the described surface of emission (8) has the surface of revolution that is made of around the rotation of axis of symmetry (S) the segment of recessed or convex curve, wherein length of curve is (I), center of curve (C) is positioned at apart from the position of axis of symmetry (S) distance for (R), wherein R ≠ 0.
3, therapy equipment according to claim 2 is characterized in that surface of revolution is made of the circular arc segment, and wherein arc length is (I), and radius is (r), and center (C) is positioned at apart from the position of axis of symmetry distance for (R), wherein R ≠ 0.
4,, it is characterized in that distance (R) is less than radius (r) according to claim 2 or 3 described therapy equipments.
5,, it is characterized in that defining and be centered close to the opening (11) that image sensor was gone up and be used to receive to axis of symmetry (S) in the center of surface of revolution according to each described treatment probe among the claim 2-4.
6, therapy equipment according to claim 1 and 2 is characterized in that ultrasonic transmitter (3) is according to concentric ring (a
1To a
2) distribute, and wherein control circuit (7) comprises signal generator, thereby described signal generator is controlled to be used for sending signal and to guarantee to focus on hat according to focal axis (A) mobile time-delay or phase rule according to being used to, and activates the ultrasonic transmitter on each described concentric ring.
7, therapy equipment according to claim 1 and 2 is characterized in that ultrasonic transmitter (3) is distributed on the fan-shaped (S of radiation
1To S
j) in, wherein control circuit (7) comprises signal generator, the controlled signal that sends of described signal generator is to guarantee that according to being used for the time-delay and the phase rule that move that focus on hat activate the fan-shaped ultrasonic transmitter of each described radiation (3).
8, therapy equipment according to claim 1 and 2, it is characterized in that ultrasonic transmitter (3) be distributed on be split into the radiation fan-shaped (S
1To S
j) concentric ring (a
1To a
i) in, wherein control circuit (7) comprises signal generator, and the controlled signal that sends of described signal generator is to guarantee that according to being used for the time-delay or the phase rule that move that focus on hat activate the fan-shaped ultrasonic transmitter of each described radiation (3).
9, therapy equipment according to claim 8 is characterized in that the fan-shaped (S of radiation of ultrasonic transmitter
1To S
j) being combined constitutes radiation group (G
1To G
k), wherein control circuit (7) comprises signal generator, the controlled signal that sends of described signal generator is to activate the ultrasonic transmitter in each described radiation group.
10, therapeutic equipment according to claim 9 is characterized in that control circuit (7) comprises signal generator, and described signal generator is controlled as each emission group (G
1To G
K) transmit and send signal to activate ultrasonic transmitter in each radiation group according to time-delay or phase rule.
11, therapy equipment according to claim 1 is characterized in that control circuit (7) comprises signal generator, and described signal generator is controlled to be used for sending signal, thereby activates the class of ultrasonic transmitter according to the order that changes or periodically repeat.
12, therapy equipment according to claim 11, it is characterized in that control circuit (7) comprises signal generator, described signal generator is controlled to be used for sending signal, thereby activation comprises different ultrasonic transmitter classes or the wherein set of at least some ultrasonic transmitter classes of identical ultrasonic generator class in set.
13, according to each described therapy equipment among the claim 9-12, it is characterized in that:
-radiation group (G
1To G
K) constitute the set of identical ultrasonic transmitter,
-control circuit (7) is connected to ultrasonic transmitter by coaxial cable (5), wherein on the one hand, the center of all ultrasonic transmitters of colleague mutually in the different radiation groups is joined together, and on the other hand, the ground of all ultrasonic transmitters of identical radiation group is connected to each other, the ultrasonic transmitter that the signal that is used to activate ultrasonic transmitter is radiated group is converted to ultrasonic energy separately, and the ground cover reason of the ultrasonic transmitter of wherein radiation group is connected to the ground of activation signal.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0652813 | 2006-07-05 | ||
| FR0652816A FR2903316B1 (en) | 2006-07-05 | 2006-07-05 | THERAPY PROBE AND THERAPY APPARATUS INCLUDING SUCH A PROBE |
| FR0652816 | 2006-07-05 | ||
| FR0652813A FR2903315B1 (en) | 2006-07-05 | 2006-07-05 | METHOD AND APPARATUS FOR SEQUENTIALLY ACTIVE ULTRASOUND EMITTER THERAPY |
| PCT/FR2007/051601 WO2008003910A1 (en) | 2006-07-05 | 2007-07-05 | Therapy apparatus with sequential functioning |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101500652A true CN101500652A (en) | 2009-08-05 |
| CN101500652B CN101500652B (en) | 2015-12-16 |
Family
ID=37762301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200780025438.3A Active CN101500652B (en) | 2006-07-05 | 2007-07-05 | There is the therapy equipment of continuous function |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN101500652B (en) |
| FR (1) | FR2903315B1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105611969A (en) * | 2013-10-08 | 2016-05-25 | Edaptms法国公司 | Method for characterising ultrasound wound in organic tissues |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3012042B1 (en) | 2013-10-23 | 2015-12-04 | Edap Tms France | APPARATUS FOR GENERATING FOCUSED ULTRASONIC WAVES WITH REDUCED PROCESSING TIME |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2620294B1 (en) * | 1987-09-07 | 1990-01-19 | Technomed Int Sa | PIEZOELECTRIC DEVICE WITH REDUCED NEGATIVE WAVES, AND USE THEREOF FOR EXTRA-BODY LITHOTRITIS OR FOR THE DESTRUCTION OF SPECIAL TISSUES |
| DE3732131A1 (en) * | 1987-09-24 | 1989-04-06 | Wolf Gmbh Richard | FOCUSING ULTRASONIC transducer |
| US4893624A (en) * | 1988-06-21 | 1990-01-16 | Massachusetts Institute Of Technology | Diffuse focus ultrasound hyperthermia system |
| JP2602923B2 (en) * | 1988-10-31 | 1997-04-23 | 株式会社東芝 | Shock wave therapy device |
| DE4302538C1 (en) * | 1993-01-29 | 1994-04-07 | Siemens Ag | Ultrasonic therapy device for tumour treatment lithotripsy or osteorestoration - with ultrasonic imaging and ultrasonic treatment modes using respective acoustic wave frequencies |
| US6692450B1 (en) * | 2000-01-19 | 2004-02-17 | Medtronic Xomed, Inc. | Focused ultrasound ablation devices having selectively actuatable ultrasound emitting elements and methods of using the same |
| US6613004B1 (en) * | 2000-04-21 | 2003-09-02 | Insightec-Txsonics, Ltd. | Systems and methods for creating longer necrosed volumes using a phased array focused ultrasound system |
| US7699780B2 (en) * | 2004-08-11 | 2010-04-20 | Insightec—Image-Guided Treatment Ltd. | Focused ultrasound system with adaptive anatomical aperture shaping |
-
2006
- 2006-07-05 FR FR0652813A patent/FR2903315B1/en active Active
-
2007
- 2007-07-05 CN CN200780025438.3A patent/CN101500652B/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105611969A (en) * | 2013-10-08 | 2016-05-25 | Edaptms法国公司 | Method for characterising ultrasound wound in organic tissues |
| CN105611969B (en) * | 2013-10-08 | 2019-01-22 | Edap Tms法国公司 | A method of for characterizing the ultrasonic wound of organic organization |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2903315A1 (en) | 2008-01-11 |
| FR2903315B1 (en) | 2016-03-11 |
| CN101500652B (en) | 2015-12-16 |
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