CN101495164A - Vascular access device volume displacement - Google Patents
Vascular access device volume displacement Download PDFInfo
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- CN101495164A CN101495164A CNA2007800282453A CN200780028245A CN101495164A CN 101495164 A CN101495164 A CN 101495164A CN A2007800282453 A CNA2007800282453 A CN A2007800282453A CN 200780028245 A CN200780028245 A CN 200780028245A CN 101495164 A CN101495164 A CN 101495164A
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Abstract
A medical device may include a vascular access device with an access port which may include a septum and a slit. The slit may be formed on the inner surface of the body of the septum and the access port may be capable of receiving a separate access device through the slit of the septum. The medical device may also include a flexible member which expands to create an additional volume within the access port when the port is accessed by the access device. A method of controlling volume displacement a chamber of a medical device may include decreasing the volume of a chamber of an extravascular system by inserting a substance having a mass into the chamber and/or increasing the volume of the chamber simultaneously and commensurately with the mass of the substance inserted into the chamber.
Description
Technical field
The present invention relates to the volume displacement in the medical apparatus and instruments, medical apparatus and instruments for example is used for providing to patient the vascular access device of injection or other therapies.Injection treatment is one of the most general health-care method.That be in hospital, home care and other patient accepts fluid, medicine and blood products by the vascular access device that is inserted in the vascular system.Injection treatment can be used for treatment to be infected, provides anesthesia or analgesia, nutritional support is provided, treats cancerous growths, keeps blood pressure and heart rate, perhaps a lot of other important clinical purposes.
Background technology
Injection treatment is implemented by the vascular access device (vascular installs outward) of patient's vascular outside.The outer device of vascular can directly or indirectly enter patient's periphery or central vein system, and the outer device of vascular comprises closed access to plant, for example the BD Q-SYTE of Becton Dickinson Co., Ltd
TMThe closed Luer access to plant; Syringe; The amalgamation access to plant; Conduit; And vein (IV) fluid chamber.But vascular access device short-term (several days), mid-term (a few week) or long-term (some months was by several years) indwelling.Vascular access device can be used for continuous injection treatment or intermittent treatment.
Common vascular access device is the plastic catheter that is inserted in the venous patient.Catheter length does not wait to being used for a lot of centimetres that the center enters from several centimetres of being used for that the periphery enters.But the conduit percutaneous inserts or passes through below the surgical operation implant patient skin.Conduit or the outer device of any other vascular that is connected thereto can have single lumen or be used for injecting simultaneously a plurality of lumens of multiple fluid.
The near-end of vascular access device generally includes the road strategic point joint that can connect other medical apparatus and instruments.For example, the administration device bag can be connected to an end of vascular access device, and the IV bag can be connected to the other end.The administration device bag is the fluid line that is used for continuous injecting fluid and medicine.Usually, the IV access to plant is such vascular access device, and it can be connected to another vascular access device, seals or seal this vascular access device, and allows intermittent infusion or inject fluid or medicine.The IV access to plant can comprise housing and barrier film, is used to seal this system.This barrier film can be opened with the male Luer of blunt sleeve pipe or medical apparatus and instruments.
Can cause very high sickness rate even mortality rate with the injection treatment complications associated with arterial system.A kind of severe complications is the relevant bloodstream infection (CRBSI) of conduit.In the United States Hospital annual occur about 250,000-400,000 routine central venous catheter (CVC) BSI that is correlated with.The related mortality that every example infects is about 12%-25%, for each accident, and the cost of health care system cost $25,000-$56,000.
The vascular access device that CRBSI causes infects may be because pathogen be inserted the back because blood enters fluid flowing path and causes at conduit.Studies show that the CRBSI risk increases during catheter retaining.Wherein partly cause is because blood is displaced to outside the vascular from patient's vascular system to be installed at least, for example conduit.After contaminated, pathogen is attached on the vascular access device, breeding, and form biofilm.Biofilm all has resistance to most biocides and the blood flow that enters patient is provided and causes the pathogen supplementary source of BSI.
The outer device of some vascular can cooperate with one another and form successive Extravascular system, and this system makes fluid enter vascular system, still seals fully with the exterior circumferential environment and separates.Prevent in the restriction of this sealing system or the imagination that deleterious antibacterial from entering patient's vascular system from the exterior circumferential environment by device outside the vascular.
But the sealing system that vascular installs (Extravascular system) outward can play the effect of sealing or sealed vacuum, blood can be pumped in the Extravascular system, can become the culture of the source of infection after the blood of this extraction.Along with device reverses away or otherwise removes from Extravascular system, the volume of Extravascular system increases sometimes slightly.Because the Extravascular system elasticity than patient's vascular system usually is little, therefore when Extravascular system volume gain, the volume of patient's vascular can reduce under from the effect of Extravascular system vacuum pressure.When the volume of vascular system reduced, blood just flow to or is extracted into Extravascular system from vascular system.And because the pressure in the Extravascular system is reduced under patient's vascular pressure, because the volume of Extravascular system can change or other incident, blood can flow into Extravascular system from vascular system.
Known in conjunction with the present invention, even the of short duration blood that occurs brings problem also can for Extravascular system operation in the future in Extravascular system.For example, blood clotting can hinder in the future at the end of the conduit of Extravascular system that fluid flows between Extravascular system and vascular system.If medicine and other flowing material are forced to pass Extravascular system, blood clot to be expelled from Extravascular system, blood clot can enter vascular system, causes dangerous thromboembolism in the patient body.At last, as mentioned above,, also can on pipe inner wall, stay residual protein, antibacterial and other pathogen even blood enters and leave the catheter tip of Extravascular system fast.This residue can become the breeding ground of bacterial growth, after a period of time, can form deleterious biofilm, and biofilm was difficult to remove or walk around in Extravascular system operating period.
Therefore, need such system and method, this system and method is avoided or limit blood is displaced to the Extravascular system that links to each other with patient's vascular from patient's vascular.
Summary of the invention
The present invention is directed to the problems of the prior art that existing Extravascular system, apparatus and method do not solve fully and need and research and develop.Therefore, the system of these research and development, apparatus and method provide a kind of like this Extravascular system, and it can be connected on patient's the vascular system, and can limit or prevent that blood from flowing or be displaced to Extravascular system from vascular system.
A kind of medical apparatus and instruments can comprise vascular access device, and this vascular access device has import and export, and it can comprise barrier film and slit.Described slit can be formed on the inner surface of described membranous main body, and described import and export can receive another access to plant by described membranous described slit.Described medical treatment device also can comprise for example elastomeric flexible member, when described access to plant enters described import and export, and the extra volume of generation in described import and export thereby described flexible member expands.The entering of another access to plant can comprise injecting a fluid in the described import and export or with frame for movement and be inserted in the described import and export.
Described medical apparatus and instruments can comprise the wriggling conduit, is used for the length delivery injection fluid along described wriggling conduit.Described medical apparatus and instruments also can have the check-valves that the injection of flexible door or fluid is passed through.Described medical apparatus and instruments can comprise that the round that is contained in the chamber maybe can form the wringing stream, and described wringing stream launches when described apparatus expands.Described medical apparatus and instruments also can comprise the gas pressure chamber, and the volume in the described import and export is contained in the fluid chamber, and when the volume-variation of described gas pressure chamber or pressure-sensitive chemical chamber, described fluid chamber volume gain.
Described medical apparatus and instruments can comprise the pillar that links to each other with described flexible structure, and described flexible structure expands when described pillar compresses.Described medical apparatus and instruments can have bubble shape thing, and described bubble shape thing expands when described device enters described import and export.Described medical apparatus and instruments also can form the wall of a compression round, and expands when described compression round pressurized.Described medical apparatus and instruments also can comprise the radial compression spring, and wherein said apparatus expands when described radial compression spring moves.
A kind of method of volume displacement of the chamber of controlling medical apparatus and instruments can comprise: be inserted into by the material that will have certain volume in the chamber of Extravascular system, reduce the volume of described chamber; Be inserted in the described chamber simultaneously and increase equally the volume of described chamber with described material with certain volume.Described material can be a frame for movement, states the tip that frame for movement can comprise syringe.Additionally or alternatively, described material can be a fluid.
A kind of medical apparatus and instruments also can comprise: be used for increasing the volumetrical device of a chamber of Extravascular system, wherein saidly be used to increase volumetrical device and link to each other equally with the device that is used to reduce described cavity volume.Describedly be used for increasing volumetrical device and be contained in the closed Luer access to plant.
These and other feature and advantage of the present invention can be included among some embodiment of the present invention, and it is more obvious to become from the following description book and claims, perhaps as mentioned below can learning in practice of the present invention.The present invention does not require that all favorable characteristics described herein and all advantages all are included among each embodiment of the present invention.
Description of drawings
To obtain the above-mentioned and easier quilt of other feature and advantage of the present invention and understand in order to make, the specific embodiment shown in is described more specifically to the present invention of above concise and to the point description with reference to the accompanying drawings.These accompanying drawings are only described exemplary embodiments of the present invention, therefore should not be considered to limit the scope of the invention.
Fig. 1 is the perspective view that is connected to the Extravascular system of patient's vascular.
Fig. 2 is the part viewgraph of cross-section that comprises the Extravascular system of flexible member.
Fig. 3 is the part viewgraph of cross-section that comprises the Extravascular system of flexible member, and flexible member has a bolus flow body.
Fig. 4 is the part viewgraph of cross-section of Extravascular system, this system made this bolus flow body by and the initial conditions of getting back to it.
Fig. 5 is the face upwarding view of vascular access device.
Fig. 6 is the check-valves of vascular access device of Fig. 5 and the part viewgraph of cross-section of flexible door.
Fig. 7 is the part viewgraph of cross-section of the check-valves of Fig. 5, illustrates and injects a certain amount of fluid.
Fig. 8 is the part viewgraph of cross-section of the check-valves of Fig. 5, and it gets back to its original position.
Fig. 9 is the viewgraph of cross-section that is connected to the vascular access device of flexible member, and flexible member is pleated or bubble shape thing or the round that rib is arranged.
Figure 10 is the vascular access device of Fig. 9 and the viewgraph of cross-section of flexible member, and wherein fluid is injected into.
Figure 11 is the plane graph of vascular access device, and wherein flexible member forms the wringing stream.
Figure 12 is the plane graph of the vascular access device of Figure 11, wherein the volume that flexible member launches and the stream demonstration is bigger.
Figure 13 is the plane graph of the vascular access device of Figure 11, and wherein flexible member is got back to its initial wringing position.
Figure 14 is the membranous part viewgraph of cross-section with flexible member, and flexible member has the gas pressure chamber.
Figure 15 is the part viewgraph of cross-section that is inserted into the tip in the barrier film of Figure 14.
Figure 16 is the membranous part viewgraph of cross-section with flexible member, and flexible member has the gas pressure chamber.
Figure 17 is the part viewgraph of cross-section that is inserted into the tip in the barrier film of Figure 16.
Figure 18 is the part viewgraph of cross-section of the vascular access device that links to each other with a pillar.
Figure 19 is the side view of Figure 18 pillar tympanites.
Figure 20 is the part viewgraph of cross-section with the vascular access device that is connected to the pillar on the projection.
Figure 21 is the part viewgraph of cross-section that is inserted into the male Luer tip in the vascular access device of Figure 20.
Figure 22 is the part viewgraph of cross-section with vascular access device of flexible member, and flexible member forms the bubble shape thing that is connected on the separator bottom, and barrier film is contained in the main body.
Figure 23 is the part viewgraph of cross-section that is inserted into the tip in the barrier film of Figure 22.
Figure 24 is the viewgraph of cross-section of an embodiment installing shown in Figure 23, and the rib on the bubble shape thing is shown.
Figure 25 is the viewgraph of cross-section of another embodiment of installing shown in Figure 23, and the pleated configuration is shown.
Figure 26 is the part viewgraph of cross-section with vascular access device of bubble shape thing, and bubble shape thing has the S shape arm that is fixed on the separator bottom.
Figure 27 is the part viewgraph of cross-section with vascular access device of bubble shape thing, and bubble shape thing has the flat arm that is fixed on the separator bottom.
Figure 28 is the perspective view of vascular access device, and this device has barrier film, stream hole, clamping ring and chock.
Figure 29 is the membranous viewgraph of cross-section of Figure 28.
Figure 30 be along with the membranous viewgraph of cross-section of Figure 26 of the viewgraph of cross-section of Figure 29 direction intercepting at an angle of 90.
Figure 31 is membranous 1/4th cross sectional view of Figure 30.
Figure 32 is the viewgraph of cross-section with vascular access device of compression round.
Figure 33 is the viewgraph of cross-section of vascular access device, and this device has below separator bottom, be filled with the chamber of material.
Figure 34 is the viewgraph of cross-section of the vascular access device of Figure 33, and the convex tip that is inserted in the barrier film is shown.
Figure 35 is the viewgraph of cross-section of vascular access device, is illustrated in most advanced and sophisticated this device before that inserts.
Figure 36 is the viewgraph of cross-section of vascular access device during insert at the tip of Figure 35.
Figure 37 is the part viewgraph of cross-section that has the slope, has the vascular access device of flexible member.
Figure 38 is the part viewgraph of cross-section that is inserted into the tip in the vascular access device of Figure 37.
The specific embodiment
Can understand currently preferred embodiment of the present invention well with reference to accompanying drawing, reference number same among the figure is indicated identical or intimate parts.Be readily understood that, can much different configurations be provided with and design with the member of the present invention that illustrates in the drawings as describe, in general terms herein.Therefore, the following more detailed description shown in figure is not the scope of the present invention that will limit as claimed in claim, and only is the representative of currently preferred embodiments of the invention.
Referring now to Fig. 1, vascular access device (be also referred to as vascular and install outward, intravenous access to plant and/or import and export) 10 is used for guiding substance and passes skin 14 through conduit 12 and enter into patient 18 blood vessel 16.Vascular access device 10 comprises main body 20, and main body 20 has lumen and the barrier film 22 that is arranged in the lumen.Barrier film 22 has slit 24, and the outer device of another vascular 26 (for example syringes) can be introduced vascular access device 10 with material by this slit 24.
As mentioning all the time in this manual, even if the of short duration blood that occurs brings problem also can for the operation in future of Extravascular system 28 in Extravascular system 28.These problems can comprise the deleterious biofilm of blood clotting, fluid flow barriers, thromboembolism and generation.Therefore, device disclosed herein is used for avoiding blood to reflux or be displaced to conduit 12 from blood vessel 16.Described device can comprise flexible member, and flexible member can produce a volume when another device 26 is inserted in the vascular access device 10, and allows the volume of this generation to be reduced to its original size.It is original when big or small when this volume is reduced to, the volumetrical volume that reduces to offset displacement when removing another access to plant 26, and fluid flows to patient's vascular system towards the far-end of vascular access device 10 or other medical apparatus and instruments.This is further avoided producing vacuum, vacuum can cause blood from blood vessel 16 flow to or suction catheter 12.
Referring now to Fig. 2, vascular access device 10 comprises at least one elastomer 34 that is connected on vascular access device 10 main bodys 20.Elastomer 34 is the wriggling conduit, is used for carrying a bolus flow body along the length of wriggling conduit.During operation, the tip 30 of another device 26 is inserted into the import and export of device 10, and fluid is 30 lumens of carrying through devices 10 from the tip, and enter elastomeric lumen.
With reference to Fig. 3, after the elastomer 34 of Fig. 2 received this bolus flow body, the outer wall of elastomer 34 was sealed in this bolus flow body back, forced this bolus flow body to flow along the vascular system of direction 36 towards patient.
With reference to Fig. 4, Fig. 2 and 3 elastomer 34 successfully are transported to patient 38 with this bolus flow body.The wall of elastomer 34 is collapsed to their initial rest positions, and prepares to receive another bolus flow body through the lumen of vascular access device 10.
Therefore, embodiment among Fig. 2 to 4 shows elastomer 34, this elastomer 34 can receive volume of fluid and transmit this fluid along direction 36 as follows towards patient, and this mode avoids blood to be back to the elastomer 34 or to connect in thereon any downstream conduit from patient's vascular system.Therefore, use the embodiment of Fig. 2 to 4, the operator can remove the tip 30 of another device 26 from vascular access device 10 safely, and the blood of certain volume can be extracted into any member of Extravascular system 28 from patient 38.
With reference to Fig. 5, the face upwarding view of vascular access device 10 illustrates check-valves 40, and this check-valves 40 can receive the lumen 42 of a certain amount of fluid by it.Device 10 also comprises elastomer 34, and this elastomer 34 forms radially, flexible, elastomer door 44.The extra volume of generation in the stream in vascular access device 10 downstreams thereby elastomer door 44 can expand.Fluid passes after the lumen 42 of check-valves 40, and check-valves 40 cuts out, and the pressure that the fluid fast injection produces makes elastomer door 44 inwardly expand towards the internal chamber of vascular access device 10.
With reference to Fig. 6, the check-valves 40 of vascular access device 10 of Fig. 5 and the cross section of elastomer door 44 are shown.In resting position, there is not the fluid injection by check-valves 40, check-valves 40 is in the flush position on the main body 20 straight, that be resisted against vascular access device 10.Same, straight, resting position that elastomer door 44 is in, reason is not have injecting fluid.Therefore the pressure in vascular access device 10 downstreams does not also increase.
Referring now to Fig. 7, the cross section among Fig. 6 is shown, wherein a certain amount of fluid 46 is being injected by check-valves 40.When fluid 46 injection during by check-valves 40, expand the under pressure internal chamber of access to plant 10 of elastomer door 44.By expansion access to plant 10, the volume that elastomer door 44 produces additional quantity in the downstream or the outside of vascular access device 10.Fluid 46 inject fully pass check-valves 40 after, check-valves 40 cuts out, elastomer door 44 turns back among Fig. 6 its initial starting position.Get back to its original position at elastomer door 44 after, its propelling fluid flows through the downstream chamber of Extravascular system 28, and enters patient's vascular system.
Referring now to Fig. 8, after fluid 46 was injected fully, as mentioned above, the original position that check-valves 40 cuts out and elastomer door 44 is got back to it along direction 48, direction 48 were downstream directions and towards patient's vascular system.
In the embodiment shown in Fig. 5 to 8, the coefficient of elasticity of elastomer door 44 should be in the blood pressure and the level between the stuffing pressure that fluid 46 injection causes during by lumen 42 of patient's vascular.Therefore, elastomer door 44 deflections when lumen 42 is passed through in fluid 46 injections.After check-valves 40 cuts out, thereby the elastic strength of elastomer door 44 is enough got back to greatly its initial position shown in Fig. 6 and 8.Fluid 46 continues along its path to flow towards patient's vascular system then.
Therefore, the embodiment of Fig. 5 to 8 allows the operator to be inserted in the vascular access device 10 another device and injecting fluid 46.After fluid 46 is injected fully, can remove this another device from vascular access device 10, and blood can be extracted into the Extravascular system 28 that vascular access device 10 is connected thereto from patient's vascular system.
Fig. 5 can carry out great change so that realize the theme of explanation here to the general conception of 8 embodiment with each member and configuration, but still within the scope of the invention.For example, the elastomer of Fig. 5 to 8 can change, and is arranged on any point of managing the external system path along the pulse, or the path of close Extravascular system.And, elastomer 34 can comprise any amount of radially, linear or other flexible door, these flexible doors can expand when fluid is injected and can shrink when one or more valves cut out.
Referring now to Fig. 9, vascular access device 10 be connected to for pleated the bubble shape thing of rib is arranged or the flexible member of round 50 on.Round 50 is arranged in the chamber 52 of housing 54.Housing 54 comprises female thread 56, is used for being connected at first end pin thread 58 of vascular access device 10.Housing 54 also comprises convex joint 58 at second end, and other downstream unit of the outer device 28 of conduit 60 or vascular can be connected on this convex joint 58.
Referring now to Figure 10, the Extravascular system 28 of Fig. 9 is shown, wherein the convex tip 30 of another device 26 is connected on the vascular access device 10.Fluid enters round 50 from another device 26 injections by installing 10, makes round 50 expand under the pressure effect that injecting fluid causes.Round 50 expansible reasons can be that convex joint 58 comprises the mobile draught excluder of suppression fluid, also can be that fluid injection enters round 50 by vascular access device 10 speed flows out the speed that round 50 enters conduit 60 greater than fluid.
The sustainable suppression fluid of draught excluder in the convex joint 58 is from round 50 inflow catheters 60, up to user pressing button 62.With medicine or other fluid after another device 26 is applied to the round 50, but user pressing button 62.Before round was filled with fluid and user pressing button 62, fluid can be trapped between the valve of the sealing slit septum (or other similar valve or closure member) of vascular access device 10 and convex joint 58.When user or operator presses button 62, the valve in the convex joint 58 is opened, and pressure fluid is discharged into the conduit 60 towards patient from round 50.
Therefore, Fig. 9 and 10 embodiment provide a kind of system, this system is included as the elastomer of round 50, round 50 provides pressure, can transport fluid into patient, and another device 26 can be removed, and does not have the risk of blood from patient's vascular system inflow catheter 60 or Extravascular system 28 other devices.Button 62 can replace with check valve, this check valve be arranged in the vascular access device 10 or the cervical region 64 of housing 54 in.When fluid entered round 50 through the valve in the cervical region 64, round 50 expanded, and after fluid was injected fully by another device 26, the pressure of round forced the valve in the cervical region 64 to be closed.Valve in cervical region 64 cuts out, when the valve in the convex joint 58 partially opens at least, and the fluid flow further downstream that round 50 promotes wherein.Fluid passes through convex joint 58, conduit 60 under pressure, and enters patient's vascular system.Flow of pressurized fluid does not allow fluid to flow into Extravascular system 28 from patient's vascular system.
Referring now to Figure 11, vascular access device 10 can comprise the elastomer that forms wringing stream 66, and wringing stream 66 manufactures in its resting state and forms the wringing chamber.The volume of wringing chamber is less than the chamber of elastomer under the expansion situation.After stream 66 launched, wringing stream or the bigger volumetrical chamber of wringing chamber 66 deployable formation made elastomer expand.The wringing stream 66 of Figure 11 can form along any part of the stream of Extravascular system 28 or close Extravascular system 28.
With reference to Figure 12, after wringing stream 66 launched, the cross section of stream illustrated the bigger volume of cross section than the wringing stream 66 of Figure 11.Wringing stream 66 begin to reverse maybe can make unfolded other the similar action of elastomer or hinged in launch.For example, when vascular access device 10 was the closed Luer access to plant, device 10 comprised the pin thread that is torqued on the syringe convex tip.When device 10 was connected on the syringe, these two devices reversed together.
Two devices are being connected together required twisting action when carrying out, wringing stream 66 changes to the bigger volumetrical expanded position shown in Figure 12 with initial, static, wringing position from Figure 11.This action appear at when wringing stream 66 when first end 68 is connected on another device 26 of syringe for example.The first meeting of syringe combines or otherwise is fixed to this first end 68 with first end 68 of wringing stream 66, and when the male Luer of syringe was reversed, this first end 68 can reverse with male Luer, makes wringing stream 66 open and launch.Then, when another device male Luer of 26 was removed, first end 68 was unfolded, made wringing stream 66 get back to its original position shown in Figure 11.
Referring now to Figure 13, after being illustrated in syringe or other another device 26 and removing from vascular access device 10, wringing stream 66 turns back to the less initial rest position of its volume.
Therefore, the embodiment that the elastomer of Figure 11 to 13 forms wringing stream 66 illustrates a kind of elastomer, and when the male Luer of another device 26 was connected on the Extravascular system 28, it can provide the volume of additional quantity in the stream of Extravascular system 28.The male Luer of another device 26 or most advanced and sophisticated 30 volumes that occupy in the Extravascular system, this volume are also offset the volume that the expansion stream 66 shown in Figure 12 produces simultaneously equally.Therefore, offset volume that Figure 12 launches stream 66 can reduce when the convex tip 30 of another device 26 insert and/or during withdrawal blood enter the probability of the Extravascular system 28 that is connected with wringing stream 66 from patient's vascular system, or eliminate this risk.
In optional embodiment, the wringing stream 66 of Figure 11 to 13 can launch under the fluidic pressure that receives from another device 26.Therefore in this particular example, another device 26 being connected to device 10 does not just need by with wringing stream 66 deployed device.On the contrary, through wringing stream 66 time, can force the wringing stream to launch from another device 26 fluidic pressure of sending, produce big volume, after fluid flow pressure reduced, the wringing stream returned to its initial wringing position then.The embodiment that adopts fluid pressure to open wringing stream 66 can be used in combination with adopting another device 26 embodiment that launch first end 68 of wringing stream 66.
Referring now to Figure 14, vascular access device 10 comprises the barrier film of being made by elastomer 72 70.In the main body of elastomer 72, gas pressure chamber 74 communicates with second gas chamber 76 by gas pressure groove 78.When another device convex tip 30 of 26 was inserted in the slit of barrier film 70, barrier film moved along outside direction 80 downwards, makes gas pressure chamber 74 expand along direction 84 simultaneously along direction 82 compressions, produces volume and have a net increase of length in gas pressure chamber 74.When gas pressure chamber 74 was volume gain, air entered gas pressure chamber 74 from second chamber 76 through gas pressure grooves 78, makes second gas chamber 76 collapse.When second gas chamber 76 collapsed, the fluid chamber 86 in the vascular access device volume gain offset most advanced and sophisticated 30 and inserts the volume that causes and reduce.
Referring now to Figure 15, the vascular access device 10 of Figure 14 is shown, wherein the tip 30 of another device 26 is inserted in the barrier film 70.As previously mentioned, most advanced and sophisticated 30 insert and cause that volume gain and second gas chamber, 76 volumes of gas pressure chamber 74 reduce equally.The reason that the second gas pressure chamber, 76 volumes reduce is, compare with elastomer 72 all the other surrounding structures around the continuous gas chamber, the sidewall 88 of the second gas pressure chamber is thinner, and pliability is perhaps more arranged, and wherein the continuous gas chamber comprises gas chamber 74, groove 78 and second chamber 76.
Therefore, Figure 14 and 15 embodiment illustrate the gas pressure chamber, and wherein the volume of the import and export of vascular access device 10 is contained in the fluid chamber 86, and the volume of fluid chamber 86 can increase simultaneously and equally with the air pressure of gas pressure chamber 74 and increase.Volume-variation in the internal chamber 86 is offset cause volume gain when most advanced and sophisticated 30 are inserted in the vascular access device.Similarly, when most advanced and sophisticated 30 when vascular access device is removed, barrier film 70 turns back among Figure 14 its original position, makes gas pressure chamber 74 and 76 get back to their initial volumes, this so that make internal chamber 86 get back to its initial volume again.The fluid of Figure 14 and 15 embodiment and the equilibrium of gas pressure chamber make most advanced and sophisticated 30 be inserted in the device 10 and can not cause blood from patient's vascular system flow into install 10 and another install 26 Extravascular systems that are connected 28.
Referring now to Figure 16, illustrate with Figure 14 and 15 in similar embodiment, wherein when the volume change of gas pressure chamber 90, gas pressure chamber 90 can change the volume of internal chamber 92.But the embodiment that describe with Figure 14 and 15 compare, when the volume of gas pressure chamber 90 reduces rather than increases, and the volume of gas pressure chamber 90 increase internal chamber 92.As shown in figure 16, vascular access device 10 comprises the elastomer 96 of barrier film 94 and formation barrier film 94 main bodys.In the housing or main body of elastomer 96, gas pressure chamber 90 is connected on the sinuous gas pressure groove 98 continuously.The end 100 of sinuous gas pressure groove 98 stops the serpentine path of gas pressure grooves 98 along the thin-walled 102 of elastomer 96.When another device tip 30 of 26 was inserted in the barrier film 94 of device 10, elastomer 96 deflections made 90 compressions of gas pressure chamber, and were forced to eluting gas pressure chamber 90 when entering sinuous groove 98 when air, and gas pressure chamber 90 is reduced to less volume.When air was forced through sinuous groove 98 arrival ends 100, the air pressure that is applied on groove 98 sidewalls made thin-walled 102 expand along direction 104.When thin-walled 102 when direction 104 expands, internal chamber 92 volume gain.
Referring now to Figure 17, the vascular access device 10 of Figure 16 is shown, wherein the tip 30 of another device 26 is inserted in the barrier film 94.Barrier film 94 is promoted along direction 106, makes gas pressure chamber 90 shrink.The gas pressure chamber 90 that shrinks promotes air and flows into the groove 98 that wriggles, and makes the thin sidewalls 102 of groove 98 and elastomer 96 expand along direction 104.Thin sidewalls 102 can be because elastomer 96 is such along the attribute of thin sidewalls 102, i.e. elastomer ratio easier expansion on horizontal 108 on axial 104 along direction 104 expansions in the present embodiment.The expansion of thin sidewalls 102 produces volumetrical recruitment in internal chamber 92, the volume offset of increase inserts owing to most advanced and sophisticated 30 and barrier film 94 enters the volume that chamber 92 volumetrical actions reduce.
Therefore, similar with the embodiment of Figure 14 and 15, but be to use opposite mechanism, Figure 16 and 17 embodiment provide a kind of elastomer and gas pressure chamber, they are displacement volume in vascular access device as follows, this mode eliminate with reduce the vascular system of blood from patient be pumped to or flow to install 10 Extravascular systems that are connected 28 probability.The embodiment of Figure 14 to 17 is not exclusive, and they only represent two examples that the principle of the invention is shown on the contrary, and principle of the present invention is that the variation of gas or fluid volume can cause the volumetrical variation of internal chamber, and this is consistent with purpose of the present invention.
Referring now to Figure 18, vascular access device 10 comprises elastomer 110, and elastomer 110 links to each other with a pillar 112 or pillar group.Pillar 112 in internal chamber 114 against the inner surface setting of the wall of elastomer 110.When another device tip 30 of 26 is inserted in the barrier film 116 of device 10, axial compressive force that causes by opening of barrier film 116 and most advanced and sophisticated 30 downward power make pillar or pillar group 112 against the inwall of elastomer 110 along outside direction tympanites, this so make elastomer 110 expand along outside direction.When pillar 112 and elastomer 110 expand and during tympanites the internal capacity increase of internal chamber 114 along outside direction.
Referring now to Figure 19, the pillar 112 of Figure 18 device 10 is shown.Pillar 112 is illustrated in outside tympanites and expansion under the axial compressive force effects that barrier film 116 opens and insert at tip 30.Compression strut can be can outwards expand under the effect of axial compression and the single continuous part of tympanites, and perhaps pillar 112 can be that one group of a plurality of joint, pillar or associated working are to realize other element of same mechanism.
Referring now to Figure 20, vascular access device 10 comprises the pillar 118 that is positioned on elastomer 120 outer surfaces.Pillar 118 is connected on the projection 122 of elastomer 120 as follows, and this mode makes pillar 118 move consistent each other with elastomer 120.
Referring now to Figure 21, the vascular access device 10 of Figure 20 is shown, wherein the male Luer tip 30 of another device 26 is inserted in device 10 barrier films 124.Opening on pillar 118 and the elastomer 120 that is connected with it of most advanced and sophisticated 30 downward power and barrier film 124 causes downward axial compressive force, forces pillar 118 and elastomer 120 outwards expansion or tympanites.When the outside tympanites of pillar 118 and elastomer 120, the internal capacity of internal chamber 126 increases in the device 10.The volumetrical increases of internal chamber 126 are offset because the opening and/or volumetrical reducing that most advanced and sophisticated 30 insertion causes of barrier film 124.Volume offset makes vascular access device 10 can receive another device any part of 26 in its barrier film 124, causes when removing or produces blood enters Extravascular system 28 from patient's vascular system situation from installing 10 and can not install 26 insertion portion at another.Elastomer of the present invention does not need to combine work with the tympanites structure that resembles with reference to the pillar shown in Figure 18 to 21, as the following embodiment that illustrates.
Referring now to Figure 22, vascular access device 10 comprises the elastomer that forms bubble shape thing 128, and bubble shape thing 128 is connected on the bottom of the barrier film 130 in the main body 132 that is contained in device 10.In its resting state, when barrier film 130 activated, bubble shape thing 128 was biased into, is oriented, mechanical realization becomes, or was configured to along direction 134 and moves.
As shown in figure 23, the vascular access device 10 of Figure 22 is shown, wherein the convex tip 30 of another device 26 is inserted in the barrier film 130, makes bubble shape thing 128 move along direction 134.When bubble shape thing 128 along direction 134, when the inner surface of the main body 132 of device 10 moves, in the internal chamber 138 of device 10, produce the storage volume 136 of additional quantity.When barrier film 130 was opened under the effect from most advanced and sophisticated 30 pressure, bubble shape thing 128 was opened naturally under the effect of trampoline effect and is expanded.Shown in Figure 24 and 25, rib 140 and/or pleat 142 can with other frame for movement or another be added to the interior and/or outer surface of bubble shape thing 128, make bubble shape thing 128 when the influencing of the barrier film 130 that is activated and move needed mechanical attributes thereby produce along direction 134.Rib 140 and pleat 142 are two kinds of possible embodiment with the bubble shape thing 128 shown in the viewgraph of cross-section, shown in the additional views of Figure 23.A certain amount of fluid pressure is when direction 134 is applied on the bubble shape thing 128 in internal chamber 138, because the embodiment of Figure 22 and 23 can force barrier film 130 to stay open, therefore as with reference to described another the embodiment of Figure 24, will be more preferably, this embodiment provides such structure, and this structure allows barrier film 130 to close when this pressure occurring.
Referring now to Figure 26, another embodiment of the embodiment shown in Figure 22 and 23 comprises the bubble shape thing 128 that has S shape arm 144, and S shape arm 144 is connected to the top of bubble shape thing 128.S shape arm 144 will steep shape thing 128 and be fixed on the bottom of barrier film 130.S shape arm 144 allows bubble shape thing 128 tympanites under the effect of fluid back pressure, allows the duckbilled of barrier film 130 partly to close simultaneously.
Referring now to Figure 27, thereby the S shape arm 144 of Figure 26 embodiment can flatten and forms flat arm 146 on the top of bubble shape thing 128.Flat arm 146 can or be in direct contact with it near the bottom of barrier film 130, so that extruding is closed as follows, this mode prevents fluid, protein, antibacterial or other pathogenic growth or retains in chamber 148.Arm 146 can flatten, and when bubble shape thing 128 and barrier film 130 used and activate, chamber 148 was eliminated fully like this.
Therefore, Figure 26 and 27 embodiment are provided at the time spent (Figure 23) of doing that is subjected to fluid pressure in the internal chamber 138 and make bubble shape thing stay open to make barrier film 130 close needed additional mechanical structure simultaneously.This additional structure (for example S shape arm 144 and flat arm 146) provides back pressure to discharge, and this makes barrier film 130 close and the tip of another device 26 is removed and increases in internal chamber 138 with barrier film 130 and close and the relevant equivalent volume of most advanced and sophisticated 30 removals.Internal chamber 138 keeps the volume of increase when bubble shape thing 128 still pressurized.Then, the volume of internal chamber 138 reduces and soars, and forces the fluid remainder of chamber 138 flow further downstream process Extravascular system 128 internally, and enters patient's vascular system.Therefore, the inefficacy of the back pressure of Figure 26 and 27 embodiment discharges or counter measure makes the operator remove another device 26 from vascular access device 10, and does not have the risk that blood enters Extravascular system 28 between the operating period from patient's vascular system the operator.
Referring now to Figure 28, vascular access device 10 comprise have stream hole 152, the barrier film 150 of clamping ring 154 and chock 156.Stream hole 152 should with aim at the hole or the lumen of the device of barrier film 150 polyphone.And hole that is communicated with stream hole 152 or lumen diameter should be slightly less than or equal stream hole 152, thereby prevent that the stream outside below stream hole 152 from forming fluid and holding back band.Fluid hold back band be fluid must through the outer side liquid of the stream straight space that can retain therein.Fluid is held back band and can be produced eddy current and other and be detained fluid, is detained fluid and retains a period of time mix with the fluid that imposes on patient then in vascular access device 10.When trap fluid was mixed with the fluid that imposes on patient afterwards, mixture may produce unexpected and unsafe consequence to patient.Design chock 156 is configured to guide barrier film 150 to enter its initial, static, the position that not have actuating.On barrier film 150 outer surfaces, form straight wall 158, be used for preventing that the inside opening of barrier film 150 from opening when the stream pressurized of bubble shape thing 160.
Referring now to Figure 29, the cross section of the barrier film 150 of Figure 28 is shown.As shown in the figure, straight wall 158 is configured to support and close the bottom 162 of barrier film 150 when compression fluid is contained in the internal chamber 164 of steeping shape thing 160.Therefore, straight wall 158 plays the effect of vertical chamber wall, prevents the slit 166 that fluid flows out through barrier film 150 from chamber 164.This design of elastomeric septum 150 provides a kind of vascular access device 10, it makes fluid flow better, make less volume in the chamber 164 need be prepared as the stream of device 10, make and when slit 166 is removed, may carry out volume displacement at the tip 30 of another device 26.
When male Luer or most advanced and sophisticated 30 was inserted in the slit 166 of barrier film 150, the bottom 162 of barrier film 150 extended into chamber 164, makes this bottom 162 outwards open.When most advanced and sophisticated 30 were inserted in the slit 166, barrier film 150 was pushed down under axial compressive force, made the thin sidewalls that steeps shape thing 160 along direction 168 outside tympanites and bendings.When the sidewall of bubble shape thing 160 is outwardly-bent, chamber 164 volume gain, thus offset because bottom 162 enters caused volume towards chamber 164 and reduces.Then, fluid is removed another device 26 by most advanced and sophisticated 30 injections.
When another installs 26 when removal, the original position that the sidewall of bubble shape thing 160 is got back to it, discharge fluid from chamber 164, and force the bottom of barrier film 150 or the original position that it is got back in bottom 162, open to prevent bottom 162 simultaneously straight vertical chamber wall 158 compressing bottoms 162.Bubble shape thing 160 comprises thin sidewalls, and thin sidewalls is along the direction bending of leaving chamber 164, and pleating or change mechanically so that promote to leave stream hole 152 tympanites when activateding.
When device 26 is removed, the original position that the wall of bubble shape thing 160 is got back to it, and fluid is from chamber 164 injections during through stream holes 152, and fluid is pushed the vascular system that enters patient from vascular access device through Extravascular system 28.This fluid flow prevents or limits this probability, and promptly blood can the vascular system from patient enter the part of Extravascular system 28 against this fluid stream.
Referring now to Figure 30, with viewgraph of cross-section the barrier film 150 of Figure 28 and 29 is shown, this viewgraph of cross-section becomes an angle of 90 degrees with the view of Figure 29.Barrier film 150 illustrates inner surface, chock 156, internal chamber 164, bubble shape thing 160 and the stream hole 152 of slit 166.
Referring now to Figure 31,1/4th cross sections of the barrier film 150 of Figure 28 to 30 are shown.This 1/4th cross section illustrates slit 166, bottom 162, straight vertical chamber wall 158, chock 156, internal chamber 164, the thin sidewalls of bubble shape thing 160 and the part in stream hole 152.As previously mentioned, chock 145 and vertically the structure of chamber wall 158 after remove from slit 166 at the tip 30 of another device 26, force the bottom 162 of barrier film 150 get back to it initial, close, resting position.Therefore, the embodiment of Figure 28 to 31 is shown as the elastomer of bubble shape thing 160, and bubble shape thing 160 expands when another device 26 enters the import and export of vascular access device 10 or barrier film 150.
Referring now to Figure 32, the viewgraph of cross-section of vascular access device 10 illustrates the top housing 168 that is connected on the bottom shell body 170.Elastomeric septum 172 is arranged in top housing 168, and link to each other with compression round or the wall 174 that overflows arc 176, thereby when membranous bottom 178 is promoted downwards by the tip 30 of another device 26, the wall 174 of compression round 176 is collapsed, and makes the fluid or the air that are contained in the compression round 176 overflow by tap 180.When another device tip 30 of 26 when barrier film 172 is removed, its original position will be got back in the bottom 178 of barrier film 172, the wall 174 of compression round 176 will be got back to its original position equally, remove the back most advanced and sophisticated 30 and recover.
Therefore, the embodiment shown in Figure 32 has elastomeric vascular access device 10, and elastomer can make the tip 30 of another device 26 insert and extract, and can not make the volume displacement in the downstream chamber 182.Because in chamber 182, do not have volume displacement, therefore inserting and/or removing any downstream chamber that the blood of patient's vascular can not enter chamber 182 or communicate with it at most advanced and sophisticated 30 o'clock.
Referring now to Figure 33, vascular access device 10 comprises: the chamber below barrier film 172 bottoms 178, and this chamber is filled with gel, closed-cell foam or other material 184; With adjacent cave, release chamber 186, discharge cave, chamber 186 and have tap 188.
Referring now to Figure 34, the vascular access device 10 of Figure 33 is shown, wherein the convex tip 30 of another device 26 is inserted in the barrier film 172, makes bottom 178 also outwards move downwards, and compressing material 184 also will be displaced to the cave, chamber of this material below bottom 178 in the release cave, chamber 186.When another device tip 30 of 26 when barrier film 172 is removed, its initial unactuated position among Figure 33 is got back in bottom 178, material 184 moves to caves, chamber below the bottom 178 from discharging cave, chamber 186 equally.Therefore, similar with the embodiment of Figure 32, Figure 33 and 34 embodiment show a kind of and compression similar structure of round or system, and it makes that volume displacement is very little in the chamber 182 in the downstream of inserting at the tip 30 of another device 26, until there not being volume displacement.
Referring now to Figure 35 and 36, Figure 35 illustrates most advanced and sophisticated 30 and inserts preceding vascular access device 10.Figure 36 illustrates this device during most advanced and sophisticated 30 insertions.This vascular inserts the radial compression spring 190 that device is included in the power that applies on the bottom 192 of barrier film 194.Therefore, most advanced and sophisticated 30 insert before, the volume of a small amount of in the chamber 196 of device 10 below its resting position that does not activate is included in the bottom 192 of barrier film 194.After most advanced and sophisticated 30 insertions, as shown in figure 36, most advanced and sophisticated 30 make barrier film 194 and its bottom 192 open downwards, promote radial spring 190 and move to the second position shown in Figure 36 from the primary importance shown in Figure 35.When radial spring 190 moved to the second position, the bottom 192 of barrier film 194 raise, and made that the cubical content in the chamber 196 increases.After most advanced and sophisticated 30 removals, the original position that them are got back in radial spring 190 and bottom 192 reduces the volume in the chamber 196.
Referring now to Figure 37, the part viewgraph of cross-section of vascular access device 10 comprises main body 198 and elastomer 200, has the member or the part of the relative stiffness of slope 202 or elastomer 200.
Ginseng Figure 38 illustrates male Luer or most advanced and sophisticated 30 and inserts the device 10 part viewgraph of cross-section of vascular access device 10 afterwards now, and described insertion forces elastomer to move along outside direction 206.When elastomer 200 when direction 206 moves, O shape ring 204 is pushed on the slope 202 that is attached thereto, and makes elastomer 200 near it or the space or the volume of recruitment be provided in the following chamber.When producing the volume of recruitment in the close chamber of elastomer 200, the volume of recruitment will be offset because the volume that most advanced and sophisticated 30 insertion causes reduces.Volume offset can prevent when removing or limit blood flow into from patient's vascular system and installs 10 Extravascular systems that are connected 28 from installing 10 most advanced and sophisticated 30.
The present invention can other particular form implement, and does not leave other key character of its structure, method or broadly described and back claim herein.The embodiment that describes should be regarded as merely illustrative in every respect, rather than restrictive.Therefore, scope of the present invention is by the explanation of appended claim, rather than by the description of front.The institute that falls into the implication of claim equivalents and scope changes and all should comprise within the scope of the claims.
Claims (20)
1. medical apparatus and instruments comprises:
The vascular access device that has import and export, described import and export have barrier film and slit, and wherein said slit is formed on the inner surface of described membranous main body, and wherein said import and export receive another access to plant by described membranous described slit; With
Flexible member, wherein when described access to plant enters described import and export, thereby described flexible member expands and produce extra volume in described import and export, makes that fluid can not be pumped in the described vascular access device when described another access to plant during from described vascular access device removal.
2. medical apparatus and instruments as claimed in claim 1, the entering of wherein said another access to plant comprise and injecting a fluid in the described import and export.
3. medical apparatus and instruments as claimed in claim 2, wherein said flexible member are the wriggling conduits, are used for carrying a bolus flow body along the length of described wriggling conduit.
4. medical apparatus and instruments as claimed in claim 2, wherein said flexible member are the elastomer door.
5. medical apparatus and instruments as claimed in claim 1 also comprises check-valves, and described fluid injection is by described check-valves.
6. medical apparatus and instruments as claimed in claim 2, wherein said flexible member are the round that is contained in the chamber.
7. medical apparatus and instruments as claimed in claim 1, wherein said flexible member forms the wringing stream, and described wringing stream launches when described flexible member expands.
8. medical apparatus and instruments as claimed in claim 1 also comprises the gas pressure chamber, and the volume in the wherein said import and export is contained in the fluid chamber, and wherein when the volume-variation of described gas pressure chamber, described fluid chamber volume gain.
9. medical apparatus and instruments as claimed in claim 1 also comprises pressure-sensitive chemical chamber, and the volume in the wherein said import and export is contained in the fluid chamber, and wherein when the volume-variation of described pressure-sensitive chemical chamber, described fluid chamber volume gain.
10. medical apparatus and instruments as claimed in claim 1, the entering of wherein said another access to plant comprise frame for movement are inserted in the described import and export.
11. medical apparatus and instruments as claimed in claim 10 also comprises the pillar that links to each other with described flexible member, wherein said flexible member expands when described pillar compresses.
12. medical apparatus and instruments as claimed in claim 10, wherein said flexible member are bubble shape things, described bubble shape thing expands when described device enters described import and export.
13. medical apparatus and instruments as claimed in claim 10, wherein said flexible member form the wall of a compression round, and expand when described compression round pressurized.
14. medical apparatus and instruments as claimed in claim 10 also comprises the radial compression spring, wherein said flexible member expands when described radial compression spring moves.
15. the method for the volume displacement of a chamber of controlling medical apparatus and instruments comprises:
Be inserted into by the material that will have certain volume in the chamber of Extravascular system, reduce described chamber volume and
Be inserted in the described chamber simultaneously and increase equally the volume of described chamber with described material with certain volume, when removing described material with certain volume, fluid can not be pumped in the described chamber like this.
16. method as claimed in claim 15, wherein said material are the frame for movement of medical apparatus and instruments.
17. method as claimed in claim 16, wherein said frame for movement are the tips of syringe.
18. method as claimed in claim 15, wherein said material is a fluid.
19. a medical apparatus and instruments comprises:
Be used for increasing the volumetrical device of Extravascular system one chamber,
Wherein saidly be used to increase volumetrical device and be associated equally with the volumetrical device that is used to reduce described chamber.
20. medical apparatus and instruments as claimed in claim 19 wherein saidly is used for increasing volumetrical device and is contained in the closed Luer access to plant.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82065706P | 2006-07-28 | 2006-07-28 | |
| US60/820,657 | 2006-07-28 | ||
| US11/829,007 | 2007-07-26 |
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| Publication Number | Publication Date |
|---|---|
| CN101495164A true CN101495164A (en) | 2009-07-29 |
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ID=40925326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007800282453A Pending CN101495164A (en) | 2006-07-28 | 2007-07-27 | Vascular access device volume displacement |
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| CN (1) | CN101495164A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109538848A (en) * | 2018-12-30 | 2019-03-29 | 中裕软管科技股份有限公司 | A kind of Novel oil gas transmission high-pressure hose and preparation method thereof |
| CN109862821A (en) * | 2016-09-09 | 2019-06-07 | 普罗根尼蒂公司 | For delivering the electromechanical Ingestible device that can allot substance |
| CN111420168A (en) * | 2020-04-01 | 2020-07-17 | 山西医科大学第一医院 | Intravenous injection device |
| US11363964B2 (en) | 2017-03-31 | 2022-06-21 | Progenity Inc. | Localization systems and methods for an ingestible device |
| US11547301B2 (en) | 2016-12-07 | 2023-01-10 | Biora Therapeutics, Inc. | Methods for collecting and testing bacteria containing samples from within the gastrointestinal tract |
| US12053271B2 (en) | 2014-09-25 | 2024-08-06 | Biora Therapeutics, Inc. | Electromechanical pill device with localization capabilities |
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2007
- 2007-07-27 CN CNA2007800282453A patent/CN101495164A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12053271B2 (en) | 2014-09-25 | 2024-08-06 | Biora Therapeutics, Inc. | Electromechanical pill device with localization capabilities |
| CN109862821A (en) * | 2016-09-09 | 2019-06-07 | 普罗根尼蒂公司 | For delivering the electromechanical Ingestible device that can allot substance |
| US11793420B2 (en) | 2016-09-09 | 2023-10-24 | Biora Therapeutics, Inc. | Ingestible device for delivery of a dispensable substance |
| US11547301B2 (en) | 2016-12-07 | 2023-01-10 | Biora Therapeutics, Inc. | Methods for collecting and testing bacteria containing samples from within the gastrointestinal tract |
| US11363964B2 (en) | 2017-03-31 | 2022-06-21 | Progenity Inc. | Localization systems and methods for an ingestible device |
| US11918342B2 (en) | 2017-03-31 | 2024-03-05 | Biora Therapeutics, Inc. | Localization systems and methods for an ingestible device |
| CN109538848A (en) * | 2018-12-30 | 2019-03-29 | 中裕软管科技股份有限公司 | A kind of Novel oil gas transmission high-pressure hose and preparation method thereof |
| CN111420168A (en) * | 2020-04-01 | 2020-07-17 | 山西医科大学第一医院 | Intravenous injection device |
| CN111420168B (en) * | 2020-04-01 | 2022-03-01 | 山西医科大学第一医院 | Intravenous injection device |
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Open date: 20090729 |