CN101474339B - Pharmaceutical composition for reducing blood sugar - Google Patents
Pharmaceutical composition for reducing blood sugar Download PDFInfo
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- CN101474339B CN101474339B CN 200810239992 CN200810239992A CN101474339B CN 101474339 B CN101474339 B CN 101474339B CN 200810239992 CN200810239992 CN 200810239992 CN 200810239992 A CN200810239992 A CN 200810239992A CN 101474339 B CN101474339 B CN 101474339B
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Abstract
The invention relates to a pharmaceutical composition for lowering blood sugar level, comprising Chinese yam, vitamin A, beta-renieratene and vitamin B complex, vitamin C, vitamin D, vitamin E, macro-elements calcium, potassium and magnesium as well as microelements zinc, selenium, iron, chromium, copper, molybdenum, iodine and manganese. The pharmaceutical composition is mainly applicable for the hyperglycemia population, effective on lowering blood sugar level and can be used for a long time or according to the course of treatment.
Description
Technical field: the present invention relates to the Medicines and Health Product technical field; Pharmaceutical composition in particular for blood sugar lowering.
Background technology: said composition comprises Rhizoma Dioscoreae, vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese.
Rhizoma Dioscoreae be a kind of be food be again the invigorating the spleen and benefiting QI class natural Chinese medicine of medicine, have that spleen invigorating, tonifying the lung are reinforced the kidney, the effect of benefit essence; Be used for diarrhea due to hypofunction of the spleen, the cough due to deficiency of the lung, quench one's thirst, seminal emission, frequent micturition, asthenia is won thin, the diseases such as lack of appetite asthenia; And chronic nephritis, bed-wetting, the women is with inferior; Modern pharmacological research confirms that Rhizoma Dioscoreae has following pharmacological action: 1, significant hypoglycemic activity is arranged; 2, the effect of slow down aging; 3, antioxidation; 4, resisting oxygen lack; 5, regulating intestinal canal flora, appetite stimulator, improve the function of digestion power; 6, health invigorating, the function of raising and adjusting immunity of human body.
Vitamin A also claims retinol, be improved vision, prevent the effect of nyctalopia, participate in the synthetic of glycogen and protein, can promote mucopolysaccharide synthetic, affect renewal, the growth of osseous tissue, long bone is grown to both-end, beta-carotene can change vitamin A under the effect of enzyme in vivo, the effect of performance vitamin A, beta-carotene has the effect that suppresses the LDL-C oxidation reaction with vitamin E, vitamin C in the mode of cooperative compensating.
Vitamin B group participates in body internal protein, fat and sugar metabolism, makes the excitement of brain cell and inhibition be in poised state, and it comprises vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid etc., in vivo collaborative performance physiological action.Vitamin B
1Participate in catabolism and the anabolism of body internal protein, fat, carbohydrate, can show vitamin B1 deficiency during shortage is the various dysbolismus of representative, in addition vitamin B
1Also participate in the neural impulse reaction, keep myocardium normal function, keep normal appetite, gastrointestinal peristalsis and digestive juice secretion etc.; Vitamin B
2Have another name called riboflavin, it is the ingredient of many important coenzyme in the body, participate in the substance metabolism in the body, guarantee that vivo oxidation reduction reaction and energy generate, participate in Antioxidative Defense System in the body, main manifestations oral cavity reproductive system syndrome, retardation of growth, iron deficiency anemia, moisture dermatitis, minimizing erythropoiesis, the systemic-function that affects the nerves, the vision etc. that reduces during shortage; Nicotiamide claims again niacin amide or vitamin PP, and its physiological function is to participate in the body intracellular metabolic, keeps normal neurological function, and pellagra can occur during shortage in synthesizing of assurance gonadal hormone etc., and main manifestations is dermatitis, diarrhoea, dull-witted three large symptoms; Pantothenic acid extensively exists in each organism, participates in widely metabolic activity, and known have 70 plurality of enzymes all to need pantothenic acid to participate in catalysis body different kind organism chemical reaction, otherwise just can Metabolic disorder; Biotin also is a kind of vitamin B group, coordinates to participate in the metabolism of human body matter and energy with other vitamin B group, and it is synthetic with nucleic acid, and the compositive relation of gonadal hormone is close, and it also has control poliosis, bareheaded effect; Vitamin B
6Play in vivo the coenzyme effect of transaminase, amino acid decarboxylases, guarantee the metabolism of the materials such as aminoacid, glycogen, fatty acid and one carbon unit, nicotinic acid, guarantee the normal propagation of the synthetic and cell of nucleic acid and protein, guarantee the homergy with neurotransmitteies such as a hydroxytryptamine, taurine, dopamine, guarantee normal immunologic function, immunity degradation during shortage also can cause neural infringement; Vitamin B
12Participate in nucleic acid in vivo, choline, amino acid whose metabolism that is synthetic and fatty and sugar, to hemopoietic function of bone marrow, the gastrointestinal epithelial cells function, liver function and nervous system myelin function complete has certain effect, it is the necessary vitamin of intelligence of bringing into normal play, not only cause dysnoesia if lack, also nutritional anemia can occur, impact is to blood supply in the brain; Folic acid participates in the synthetic of aminoacid and nucleic acid, and and vitamin B
12The common generation that promotes cell is with ripe, and normal cell can not carry out mitosis during shortage, the neurological symptom can occur, as: the loss of memory, depression and dementia etc.;
Vitamin C claims again ascorbic acid, vitamin C and collagen in close relations, the vessel softening effect is not only arranged, and the effect that purifies the blood in addition prevents arteriosclerosis, in cholesterol metabolism, play an important role, can effectively reduce neutral fat, can also promote human body to the absorption of ferrum in the food, for hemopoietic provides essential raw material, simultaneously, vitamin C regain one's strength, the aspect effect such as allaying tiredness, keeping tensions down emotion is obvious;
Vitamin D is the sterols derivant, and the subcutaneous dehydrocholesterol of human body produces vitamin D through ultraviolet radiation
3, ergosterol produces vitamin D behind ultraviolet radiation
2, the two originates different, and function is consistent, and the importance of vitamin D is to regulate the metabolism of calcium and phosphorus in human nutrition; Vitamin D promotes calcium at intestinal absorption, be deficient in vitamin D then a large amount of calcium discharged by feces, thereby cause the human body calcium deficiency, rickets can occur in the child, become the calcium phosphorus of storing in the human body to exhaust and can cause osteomalacia, modal osteomalacia crowd is anemia of pregnant woman, wet nurse and old people.
Vitamin E is all general designations with the bioactive chromone derivative of alpha-tocopherol, and wherein the activity of alpha-tocopherol is the highest, has antioxidation, avoids the effect of biomembrane generation lipid peroxidation; The effect that stops LDL oxidation to form, thereby the generation of atherosclerosis and cardiovascular disease; Also have to regulate in addition immunity, slow down aging, inhibition tumor, promote fetal development and reproductive performance to reach the protective effect of nerve and skeleton etc.
Trace element zinc is merged in the biomacromolecule ligand---in protein, nucleic acid, the film (being mainly memebrane protein), generate stable metallic biomacromolecule complex---metalloprotein, metalloproteinase nucleic acid complex etc., at present, known these materials participate in the synthetic and degradation process of carbohydrate, lipid, protein and nucleic acid, and the existence of zinc enzyme is arranged in six large fermentoids; Zinc also is the essential element that strengthens immune vigor; Zinc can promote that proinsulin is converted into insulin by activating protaminase, and zinc deficiency makes insulin be obstructed in the activity of peripheral tissues, and it is unusual to cause glucose tolerance curve.
Trace element-selenium has obvious reduction serum total cholesterol, triglyceride and lipid peroxide, improves high density lipoprotein, the effect of superabundant fats metabolism in the acceleration bodies; Selenium also has the strong anti-oxidation function, but prevention of cardiac; Anticancer by strengthening immune recognition system to remove cancerous cell; Remove and the drainage heavy metal ion, hydrargyrum, methyl mercury, cadmium, lead etc. are had Detoxication; Scarce selenium can make the human insulin secretion reduce, impaired glucose tolerance, and oxidation resistance descends and accelerates human senility and intelligence decline.
The main Physiological Function of trace elements iron is as hemoglobin, Myoglobin, and the ingredient of cytochrome etc. participates in transporting and the Tissue respiration process of the interior oxygen of body; In the conveying of oxygen and electronics, play central role; Contain ferrum in the catalatic structure, and hydrogen peroxide relies on catalatic degraded, hydrogen peroxide is free radical the most dangerous in the human body; Iron deficiency is common in infant, anemia of pregnant woman and wet nurse, causes iron deficiency anemia, and its cardinal symptom is to have a delicate constitution, and memory weakens, and ability to work descends, and iron deficiency also can exert an influence to other system of human body; Such as the nervous system iron deficiency, can affect the nerves conduction and make the child occur that intelligence reduces and behavior disorder.
Chromium is insulin " collaborative hormone ", strengthen the effect of insulin with the activated organochromium compounds of tool " glucose tolerance factor (GTF) " form, mainly be to keep the normal carbohydrate metabolism of body and lipid metabolism, following symptom can occur when not enough: weaken glucose tolerance, increase the weight of hyperglycemia, glucose in urine, hypoglycemia, the circulation of acceleration insulin, reduce Insulin receptor INSR quantity, reduce the insulin binding ability, lose weight, increase fat content, increase vision pressure etc.The chromium of two kinds of valence states of stable existence in the environment, i.e. trivalent chromium and Cr VI, trivalent chromium has physiologically active, uses useful and harmlessly in an amount of scope, and Cr VI is a kind of strong oxidizer, and human body is had toxic and side effects.
Copper is the active component of 30 plurality of enzymes such as lysyl oxidase in the body, cytochrome oxidase, monoamine oxidase, MAO, participates in the redox reaction of cell.When lacking copper, the catalysis cholesterol changes 7 α of cholic acid-hydroxyl enzyme into and 12 α-hydroxylase activity reduces, cholesterol biosynthesis and eliminate and reduce, and cholesterol is discharged and is obstructed, and causes hyperlipemia.Absolute or relative copper lacks can make serum TC, TG level raise, and causes high-cholesterol disease.
Molybdenum is one of micro elements needed by human, and it is the Constitution Elements of plurality of enzymes, can help the metabolism of carbohydrate and fat, it participates in removing the murder by poisoning of poisonous aldehydes in the human body, eliminate human free radical, have anticancer, defying age, enhancing immunity and anticariogenic function; Scarce molybdenum can bring out cardiovascular disease, cancer and dental caries.
Iodine is the main synthetic thyroid element that participates in human body, and thyroxinic physiological function is to regulate the organism metabolism level, affects the generation of body heat energy, blood glucose and ketoboidies level, muscle and nervous, many-sided functions such as body weight, intelligence and sexual function; Adult's iodine deficiency can cause thyromegaly.
Manganese participates in the formation of some enzymes in human body, it is the metabolism of involved in sugar and lipid not only, and all works in protein, DNA and RNA are synthetic.
Calcium is the macroelement that body weight for humans is wanted, main two aspects that play a part, the one, consist of the sclerous tissueses such as bone tooth, the 2nd, consist of the material that specific function is arranged with protein bound or with the form of calcium ion, form in so-called miscible calcium pool and the bone tooth calcium and keep dynamic equilibrium, all cells all need its normal function of calcium competence exertion in the body; Anemia of pregnant woman and wet nurse's calcium deficiency can affect the growth of its body constitution and fetus or infant, and calcium deficiency can cause that also endocrine dysfunction and cell cycle regulation are malfunctioning, and anemia of pregnant woman and wet nurse are owing to physiological characteristics, the Deficiency of Intake of ubiquity calcium.
Potassium participates in the metabolic activity of cell, for the normal activity of some enzyme provides suitable condition, its outstanding effect is to keep the normal irritability of myocardial cell, self-disciplining and conductivity, is regulating acid-base balance, keeps osmotic pressure and keeps the water balance aspect to play an important role; Hypokalemia and hyperkalemia all can produce serious infringement to human body, and the lighter can cause tired, irritated, and severe one can cause arrhythmia, even dead.
Magnesium topmost function in human body is the generation of containment free radical, and free radical is short old and feeble factor, also is the factor that mainly causes birth defect; Another function of magnesium is to bring into play the effect of protection skeleton with calcium and vitamin D, and osteoporosis occurs magnesium deficiency easily, fractures easily; Magnesium also has cardioprotection and prevents and treats the function etc. of diabetes in addition.
Application contains Rhizoma Dioscoreae, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, vitamin B
6, nicotiamide, pantothenic acid, biotin, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese is known as the compositions of active component, but with Rhizoma Dioscoreae, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese compatibility not yet report for reducing the pharmaceutical composition of blood glucose.
Current medicine or health food kind for reducing blood glucose has multiplely, but has the medicine of side effect more, and the health food target spot is few, and the link shortcoming needs perfectly, and cost is high, and price is high.
Summary of the invention: in order to overcome the shortcoming and defect of existing blood sugar lowering medicine, the purpose of this invention is to provide a kind of compositions, said composition is by collaborative vitamin A, beta-carotene, the vitamin B of increasing of Rhizoma Dioscoreae
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese blood sugar lowering effect, simultaneously by macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese and vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E, replenish and strengthen the effect of Rhizoma Dioscoreae blood sugar lowering, even chronic administration is also without any side effect; Because the result of broad research, the inventor have found Rhizoma Dioscoreae and vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese novel combination, this novel combination has synergy for blood sugar lowering; And alone Rhizoma Dioscoreae and vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese, its effect is all not as good as this compositions; There is not incompatibility in this compositions, have no side effect, and cost is low, thereby consists of the present invention.
The invention provides the pharmaceutical composition for reducing blood glucose, it comprises as the Rhizoma Dioscoreae of active component and vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese.
Rhizoma Dioscoreae is the rhizome of Dioscoreaceae plant Rhizoma Dioscoreae (Dioscorea opposita Thunb.), Rhizoma Dioscoreae another name Rhizoma Dioscoreae, Rhizoma Dioscoreae etc.; All produce in Henan, Hebei, Shaanxi, Jiangsu, Zhejiang, Jiangxi; But take bosom, the Henan celebrating product person of institute as excellent, the title of " RHIIZOMA DIOSCOREAE fr0m Henan of China " is arranged; The used Rhizoma Dioscoreae of the present invention can be with its extract as raw material.
Be used for vitamin B of the present invention
1(VitaminB
1), vitamin B
2(VitaminB
2), nicotiamide (Nicotinamide), pantothenic acid (Pantothenic Acid), biotin (Vitamin H), vitamin B
6(VitaminB
6), vitamin B
12(VitaminB
12), folic acid (Folic Acid), vitamin C (VitaminC), all are water soluble vitamins, do not accumulate in vivo; Vitamin A (Vitamin A), vitamin D (VitaminD), vitamin E (Vitamin E) are fatsoluble vitamiies, beta-carotene (Beta Carotene) is the precursor substance of vitamin A, and is useful and harmless by the used dosage of the present invention; Zinc (Zn), selenium (Se), ferrum (Fe), chromium (Cr), copper (Cu), molybdenum (Mo), iodine (I) are micro elements needed by human, manganese (Mn) is human body possibility essential trace element, and calcium (Ca), potassium (K), magnesium (Mg) are the macroelements of needed by human; Macroelement calcium among the present invention can be selected calcium gluconate, calcium acetate, calcium caseinate, calcium chloride, calcium citrate, calcium malate, calcium cirate malate, calcium hydrogen phosphate, dalcium biphosphate, calcium phosphate, calcium sulfate, calcium ascorbate, calcium glycerophosphate, calcium lactate, calcium carbonate etc., macroelement potassium can be selected potassium carbonate, potassium chloride, potassium citrate, dipotassium hydrogen phosphate, potassium gluconate, potassium sulfate, potassium glycerinophosphate, potassium lactate etc., macroelement magnesium can be selected magnesium chloride, magnesium gluconate, magnesium lactate, magnesium citrate, magnesium hydrogen phosphate, magnesium phosphate, magnesium glycerophosphate, magnesium carbonate etc., trace element zinc can be selected zinc citrate, zinc gluconate, zinc acetate, zinc carbonate, zinc oxide, zinc chloride, zinc lactate, zinc sulfate, single zinc methionine etc., trace element-selenium can be selected Selenomethionine, methoxybenzyl cyanic acid selenium, the two cyanic acid selenium of phenylene, sodium selenite, selenocarrageenan, selenocysteine, the selenizing methionine, sodium selenate etc., trace elements iron can be selected Ferrous gluconate, ferrous lactate, ferric ammonium citrate, iron chloride, ferric citrate, ferrous carbonate, ferrous citrate, ferrous fumarate, heme iron, ferric phrophosphate, protohemin, ferrous succinate, ferrous sulfate etc., trace element chromium can be selected chromium trichloride, nicotinic acid chromium, chromium picolinate, the trivalent chromiums such as chromium yeast, trace copper can be selected curpic carbonate, copper citrate, copper gluconate, copper sulfate etc., trace element molybdenum can be selected ammonium molybdate, sodium molybdate etc., trace iodine can be selected potassium iodate etc., trace element manganese can be selected manganese sulfate, manganese gluconate, manganese glycerophosphate, manganese chloride, manganese citrates etc. all have professional production factory and supplier.
Compositions of the present invention mainly is applicable to hyperglycemia population, and by the present invention, the effective dose of Rhizoma Dioscoreae is counted 6000-15000mg days with whole crude drug, vitamin B
1Effective dose be 0.5-20mg/ days, vitamin B
2Effective dose be 0.5-20mg/ days, the effective dose of nicotiamide is 5-50mg/ days, the effective dose of pantothenic acid is 2-20mg/ days, the effective dose of biotin is 0.01-0.1mg/ days, vitamin B
6Effective dose be 0.5-10mg/ days, vitamin B
12Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, ascorbic effective dose is 30-500mg/ days, and the effective dose of vitamin A and/or beta-carotene (take retinol equivalent) is 250-800 μ gRE/ days; The effective dose of vitamin D is 0.0015-0.01mg/ days, the effective dose of vitamin E (take the alpha-tocopherol equivalent) is 5-150mg α-TE/ days, the effective dose of macroelement calcium is counted 250-1000mg/ days with element calcium, the effective dose of potassium is counted 200-1200mg/ days with Element Potassium, the effective dose of magnesium is counted 100-300mg/ days with element magnesium, the effective dose of trace element zinc is counted 5-20mg/ days with element zinc, the effective dose of selenium is counted 0.015-0.1mg/ days with elemental selenium, and the effective dose of ferrum is counted 5-20mg/ days with elemental iron.The effective dose of chromium is counted 0.015-0.15mg/ days with elemental chromium, the effective dose of copper is counted 0.5-1.5mg/ days with elemental copper, the effective dose of molybdenum is counted 0.02-0.06mg/ days with molybdenum, the effective dose of iodine is counted 0.05-0.2mg/ days with elemental iodine, and the effective dose of manganese is counted 1-3mg/ days with element manganese.
Compositions of the present invention can or directly be taken by following pharmaceutical dosage forms dispenser, for example, oral formulations is (such as granule, powder, capsule, ball, sheet, dry syrup, liquid formulation), or food such as food (such as cookies), to mix and prepare with other known additive, this class additive is for example: carrier, disintegrating agent, slow releasing agent, excipient, filler, covering, binding agent, lubricant, antioxidant, coating agent, coloring agent, correctives, sweeting agent, sucrose succedaneum, nutrition enhancer, flavouring agent, surfactant, plasticizer, the PH regulator, freshener, suspending agent, defoamer, antiseptic, thickening agent, solubilisation aids etc. are prepared or they are added food as functional component or additive by usual way.
By the present invention, Rhizoma Dioscoreae, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, potassium, magnesium and trace element zinc, selenium, ferrum, chromium, copper, molybdenum, iodine, manganese each component can distinguish preparation, use after the preparation of each component can being mixed when using or do not mix simultaneously and use.
Advantage of the present invention be this compositions from too many levels, multisystem, many target spots blood sugar lowering, the effect of collaborative performance effect is arranged between the each component, blood sugar lowering is had significant effect, sufficient raw, cost is low, and each component has no side effect in the compositions, without incompatibility.
Subordinate list 1 causes diabetic mice blood sugar lowering test effect relatively for this compositions and Rhizoma Dioscoreae component and vitamin added elements component to alloxan.
Relatively tabulate to be described in detail the present invention below with reference to embodiment and test implementation example effect.
Embodiment 1:
Rhizoma Dioscoreae 9500mg,
Vitamin B
13mg,
Vitamin B
23mg,
Vitamin B
62mg,
Folic acid 0.3mg,
Vitamin B
120.003mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace element-selenium) 0.02mg,
Chromium picolinate (in trace element chromium) 0.08mg,
Copper citrate (in trace copper) 0.8mg,
Molybdic acid is received (through the trace element molybdenum meter) 0.3mg,
Potassium iodate (in trace iodine) 10mg,
Manganese citrate (in trace element manganese) 1.5mg,
Magnesium citrate (in trace element magnesium) 200mg,
Retinol equivalent (vitamin A and/or beta-carotene) 600mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 2:
Rhizoma Dioscoreae 9800mg,
Vitamin B
13mg,
Vitamin B
23mg,
Vitamin B
62mg,
Folic acid 0.3mg,
Vitamin B
120.003mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 8mg,
Sodium selenate (in trace element-selenium) 0.02mg,
Chromium picolinate (in trace element chromium) 0.06mg,
Copper citrate (in trace copper) 0.8mg,
Molybdic acid is received (in trace element molybdenum) 0.5mg,
Potassium iodate (in trace iodine) 0.1mg,
Manganese citrate (in trace element manganese) 2mg,
Calcium lactate (in element calcium) 600mg,
Magnesium lactate (in element magnesium) 200mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 3:
Rhizoma Dioscoreae 10000mg,
Vitamin B
13mg,
Vitamin B
23mg,
Vitamin B
62mg,
Folic acid 0.3mg,
Vitamin B
120.003mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace element-selenium) 0.02mg,
Ferric citrate (in trace elements iron) 10mg,
Chromium yeast (in trace element chromium) 0.02mg,
Copper citrate (in trace copper) 0.8mg,
Sodium molybdate (in trace element molybdenum) 0.03mg,
Manganese citrate (in trace element manganese) 1.2mg,
Potassium iodate (in trace iodine) 0.1mg,
Calcium lactate (in element calcium) 600mg,
Magnesium citrate (in trace element magnesium) 250mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 4:
Rhizoma Dioscoreae 12000mg,
Vitamin B
13mg,
Vitamin B
23mg,
Vitamin B
62mg,
Folic acid 0.3mg,
Vitamin B
120.003mg,
Nicotiamide 10mg,
Pantothenic acid 10mg,
Biotin 0.6mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace element-selenium) 0.02mg,
Ferric citrate (in trace elements iron) 10mg,
Chromium yeast (in trace element chromium) 0.02mg,
Copper citrate (in trace copper) 0.8mg,
Sodium molybdate (in trace element molybdenum) 0.03mg,
Potassium iodate (in trace iodine) 0.1mg,
Manganese citrate (in trace element manganese) 2mg,
Calcium lactate (in element calcium) 600mg,
Magnesium lactate (in element magnesium) 200mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Take every day 3 times, each serving a bag.
Embodiment 5:
Rhizoma Dioscoreae 6000mg,
Vitamin B
10.5mg,
Vitamin B
20.5mg,
Vitamin B
60.5mg,
Folic acid 0.1mg,
Vitamin B
120.001mg,
Nicotiamide 5mg,
Pantothenic acid 2mg,
Biotin 0.01mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 5mg,
Sodium selenate (in trace element-selenium) 0.015mg,
Ferric citrate (in trace elements iron) 5mg,
Chromium yeast (in trace element chromium) 0.015mg,
Copper citrate (in trace copper) 0.5mg,
Sodium molybdate (in trace element molybdenum) 0.02mg,
Potassium iodate (in trace iodine) 0.05mg,
Manganese citrate (in trace element manganese) 1mg,
Calcium lactate (in element calcium) 250mg,
Potassium lactate (in Element Potassium) 200mg
Magnesium lactate (in element magnesium) 100mg,
Retinol equivalent (vitamin A and/or beta-carotene) 250 μ g RE,
Vitamin D 0.0015mg,
Vitamin E (in the alpha-tocopherol equivalent) 5mg α-TE.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Take every day 3 times, each serving a bag.
Embodiment 6:
Rhizoma Dioscoreae 15000mg,
Vitamin B
120mg,
Vitamin B
220mg,
Vitamin B
610mg,
Folic acid 1mg,
Vitamin B
120.025mg,
Nicotiamide 50mg,
Pantothenic acid 20mg,
Biotin 0.1mg,
Vitamin C 500mg,
Zinc lactate (in trace element zinc) 20mg,
Sodium selenate (in trace element-selenium) 0.1mg,
Ferric citrate (in trace elements iron) 20mg,
Chromium yeast (in trace element chromium) 0.15mg,
Copper citrate (in trace copper) 1.5mg,
Sodium molybdate (in trace element molybdenum) 0.06mg,
Potassium iodate (in trace iodine) 0.2mg,
Manganese citrate (in trace element manganese) 3mg,
Calcium lactate (in element calcium) 1000mg,
Potassium lactate (in Element Potassium) 1200mg
Magnesium lactate (in element magnesium) 300mg,
Retinol equivalent (vitamin A and/or beta-carotene) 800 μ g RE,
Vitamin D 0.01mg,
Vitamin E (in the alpha-tocopherol equivalent) 150mg α-TE.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Take every day 3 times, each serving a bag, serve on 10, withdrew 5, take again 10.
Belong to nontoxic level through animal experiment proved compositions; The crowd takes and also has no toxicity.
Embodiment 7: this compositions causes diabetic mice blood sugar lowering test effect relatively with each component to alloxan.
Select 60 of Kunming mouses, male female half and half; Wherein 48 mices are male female half and half, and fasting is after 16 hours, tail vein injection alloxan 70mg/kg
-1, after 72 hours, measure fasting blood sugar, blood glucose value is higher than 16.7mmol/L
-1The person is the hyperglycemia mice, according to blood sugar level the hyperglycemia mice is divided into 4 groups: model control group (B group), and the C group, the D group, the E group, each group of test is pressed 0.2mL/10g
-1Continuous 10 days of body weight gastric infusion, fasting in the 10th day gastric infusion after 7 hours is measured after the administration 1 hour with method, 2 hours blood glucose value; 12 remaining mices, as Normal group (A group), model control group and Normal group every day are to equal-volume normal saline gavage once.
Related data sees attached list 1.
Subordinate list 1: this compositions causes diabetic mice blood sugar lowering test effect relatively with Rhizoma Dioscoreae component and vitamin added elements component to alloxan:
From table 1, can obviously find out, take this composite preparation and take Rhizoma Dioscoreae component and vitamin added elements component contrast diabetic mice blood sugar lowering test effect the difference of highly significant is arranged.
Claims (5)
1. pharmaceutical composition for reducing blood glucose is characterized in that it is made by weight ratio by following raw materials according:
2. the pharmaceutical composition for reducing blood glucose according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
3. the pharmaceutical composition for reducing blood glucose according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
4. the pharmaceutical composition for reducing blood glucose according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
5. the pharmaceutical composition for reducing blood glucose according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
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Non-Patent Citations (4)
| Title |
|---|
| 山药对糖尿病小鼠血糖、血脂、肝糖元和心肌糖元含量的影响;舒思洁等;《咸宁医学院学报》;19981230;第12卷(第04期);223-226 * |
| 微量元素和维生素对四氧嘧啶致糖尿病小鼠模型的影响;赵蕊等;《黑龙江八一农垦大学学报》;20100228;第22卷(第1期);58-61 * |
| 舒思洁等.山药对糖尿病小鼠血糖、血脂、肝糖元和心肌糖元含量的影响.《咸宁医学院学报》.1998,第12卷(第04期),223-226. |
| 赵蕊等.微量元素和维生素对四氧嘧啶致糖尿病小鼠模型的影响.《黑龙江八一农垦大学学报》.2010,第22卷(第1期),58-61. |
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