CN101474176A - Pharmaceutical composition of flucloxacillin sodium and amoxicillin sodium and production method thereof - Google Patents
Pharmaceutical composition of flucloxacillin sodium and amoxicillin sodium and production method thereof Download PDFInfo
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- CN101474176A CN101474176A CNA2009100076298A CN200910007629A CN101474176A CN 101474176 A CN101474176 A CN 101474176A CN A2009100076298 A CNA2009100076298 A CN A2009100076298A CN 200910007629 A CN200910007629 A CN 200910007629A CN 101474176 A CN101474176 A CN 101474176A
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- flucloxacillin
- amoxicillin
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- amoxicillin sodium
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Abstract
The invention discloses a flucloxacillin sodium amoxicillin sodium pharmaceutical composition, comprising amoxicillin sodium and flucloxacillin sodium, weight ratio thereof being 5-1:1-10. The invention has the advantages of simple prescription, operable preparation technique, low cost, rapid redissolution, good clarity after redissolution and high purity.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition of flucloxacillin sodium and amoxicillin sodium and method for making thereof.
Background technology
Flucloxacillin sodium, chemistry is by name: (2S, 5R, 6R)-6-[[3-(2-chloro-6-fluorophenyl)-5-methyl isophthalic acid, 2-oxazole-4-formyl] amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-formic acid sodium salt, belong to the 4th Dai isoxazole penicillin, be characterized in being difficult for being destroyed, the drug resistance staphylococcus aureus that produces penicillinase is had bactericidal action by penicillinase, be mainly used in the penicillin resistant staphy lococcus infection, but gram-negative bacteria is to the flucloxacillin drug resistance.
Amoxicillin Sodium is semisynthetic side's spectrum penicillin, belongs to the ampicillin class, and Grain-negative and positive bacteria are all had bactericidal action, is characterized in wide spectrum, not the penicillin resistant enzyme.
Both antibacterial action mechanism is identical with penicillin, all is by combining with antibacterial penicillium sp conjugated protein (PBPs), disturbing the synthetic of a bacterial cell ancient piece of jade, round, flat and with a hole in its centre and an antibacterial action.After flucloxacillin sodium and the Amoxicillin Sodium associating, can play antibacterial action to staphylococcus bacterium producing multi enzyme preparation and some gram-negative bacteria sensitive strain.Be applicable to responsive microbial respiratory tract infection, digestive tract infection, urinary tract infection, skin soft-tissue infection, bone and the infection of joint, oral cavity and otorhinolaryngology infection etc. clinically.
Summary of the invention
The purpose of this invention is to provide a kind of pharmaceutical composition of flucloxacillin sodium and amoxicillin sodium, the said composition prescription is simple, but economical and practical, can be made into injection or powder.
For solving the problems of the technologies described above, technical scheme provided by the present invention is: a kind of pharmaceutical composition of flucloxacillin sodium and amoxicillin sodium, include Amoxicillin Sodium and flucloxacillin sodium, and the two ratio of weight and number is 5～1:1～10.
Preferably, the ratio of weight and number of described Amoxicillin Sodium and flucloxacillin sodium is 2～1:1～5.
Best, the ratio of weight and number of described Amoxicillin Sodium and flucloxacillin sodium is 1:1.
A kind of preparation method of aforesaid pharmaceutical composition of flucloxacillin sodium and amoxicillin sodium, this preparation method is: flucloxacillin sodium and Amoxicillin Sodium are mixed in proportion behind 80～100 mesh sieves respectively excessively, packing under 100 grades of conditions in sterilizing room then promptly makes the flucloxacillin sodium pharmaceutical composition.
Flucloxacillin provided by the invention sodium pharmaceutical composition, but intravenous injection or intravenous drip, 2～4g/ day, divide 2～4 injections, or be dissolved in the 20ml water for injection, in 3～4 minutes, instil in slow notes or the adding transfusion; Also but intrathoracic injection, is dissolved in 5～10ml water for injection 250mg/ day; Joint cavity injection, is dissolved in the 5ml water for injection 250～500mg/ day.
The advantage that the present invention has: prescription is simple, and preparation technology is easy to operate, and cost is low, redissolves soon, and the back clarity of redissolving is good, the purity height.
The specific embodiment:
The preparation of embodiment 1 amoxicillin sodium for injection flucloxacillin sodium
The Amoxicillin Sodium 100g that gets flucloxacillin sodium 100g and list marketing crosses mix homogeneously behind 80 mesh sieves respectively, packing under 100 grades of conditions in sterilizing room then, every bottle of fluorine-containing chlorine XiLin 0.25g, amoxicillin sodium for injection flucloxacillin composition of sodium.
The preparation of embodiment 2 Amoxicillin Sodium flucloxacillin sodium powder
The Amoxicillin Sodium 20g that gets flucloxacillin sodium 100g and list marketing crosses mix homogeneously behind 100 mesh sieves respectively, packing under 100 grades of conditions in sterilizing room then, every bottle of fluorine-containing chlorine XiLin 0.5g, amoxicillin sodium for injection flucloxacillin composition of sodium.
The preparation of embodiment 3 amoxicillin sodium for injection flucloxacillin sodiums
The Amoxicillin Sodium 300g that gets flucloxacillin sodium 30g and list marketing crosses mix homogeneously behind 90 mesh sieves respectively, packing under 100 grades of conditions in sterilizing room then, every bottle of fluorine-containing chlorine XiLin 1g, amoxicillin sodium for injection flucloxacillin composition of sodium.
The preparation of embodiment 4 Amoxicillin Sodium flucloxacillin sodium powder
The Amoxicillin Sodium 160g that gets flucloxacillin sodium 80g and list marketing crosses mix homogeneously behind 85 mesh sieves respectively, packing under 100 grades of conditions in sterilizing room then, every bottle of fluorine-containing chlorine XiLin 1.5g, amoxicillin sodium for injection flucloxacillin composition of sodium.
The preparation of embodiment 5 amoxicillin sodium for injection flucloxacillin sodiums
The Amoxicillin Sodium 100g that gets flucloxacillin sodium 20g and list marketing crosses mix homogeneously behind 95 mesh sieves respectively, packing under 100 grades of conditions in sterilizing room then, every bottle of fluorine-containing chlorine XiLin 2g, amoxicillin sodium for injection flucloxacillin composition of sodium.
The preparation of embodiment 6 Amoxicillin Sodium flucloxacillin sodium powder
The Amoxicillin Sodium 50g that gets flucloxacillin sodium 20g and list marketing crosses mix homogeneously behind 88 mesh sieves respectively, packing under 100 grades of conditions in sterilizing room then, every bottle of fluorine-containing chlorine XiLin 3g, amoxicillin sodium for injection flucloxacillin composition of sodium.
The above, it only is preferred embodiment of the present invention, be not that the present invention is done any pro forma restriction, though the present invention discloses as above with preferred embodiment, yet be not in order to limit the present invention, any those skilled in the art, in not breaking away from the technical solution of the present invention scope, when the technology contents that can utilize above-mentioned announcement is made a little change or is modified to the equivalent embodiment of equivalent variations, in every case be the content that does not break away from technical solution of the present invention, according to technical spirit of the present invention to any simple modification that above embodiment did, equivalent variations and modification all still belong in the scope of technical solution of the present invention.
Claims (4)
1, a kind of pharmaceutical composition of flucloxacillin sodium and amoxicillin sodium includes Amoxicillin Sodium and flucloxacillin sodium, and the two ratio of weight and number is 5～1:1～10.
2, pharmaceutical composition of flucloxacillin sodium and amoxicillin sodium according to claim 1 is characterized in that: the ratio of weight and number of described Amoxicillin Sodium and flucloxacillin sodium is 2～1:1～5.
3, pharmaceutical composition of flucloxacillin sodium and amoxicillin sodium according to claim 1 is characterized in that: the ratio of weight and number of described Amoxicillin Sodium and flucloxacillin sodium is 1:1.
4, a kind of preparation method as the arbitrary described pharmaceutical composition of flucloxacillin sodium and amoxicillin sodium of claim 1 to 3, this preparation method is: flucloxacillin sodium and Amoxicillin Sodium are mixed in proportion behind 80～100 mesh sieves respectively excessively, packing under 100 grades of conditions in sterilizing room then promptly makes the flucloxacillin sodium pharmaceutical composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100076298A CN101474176B (en) | 2009-02-12 | 2009-02-12 | Pharmaceutical composition of flucloxacillin sodium and amoxicillin sodium and production method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100076298A CN101474176B (en) | 2009-02-12 | 2009-02-12 | Pharmaceutical composition of flucloxacillin sodium and amoxicillin sodium and production method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101474176A true CN101474176A (en) | 2009-07-08 |
| CN101474176B CN101474176B (en) | 2010-08-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009100076298A Expired - Fee Related CN101474176B (en) | 2009-02-12 | 2009-02-12 | Pharmaceutical composition of flucloxacillin sodium and amoxicillin sodium and production method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103330711A (en) * | 2013-07-11 | 2013-10-02 | 广州安健实业发展有限公司 | Flucloxacillin sodium and amoxicillin sodium for injection |
| CN103622956A (en) * | 2013-12-16 | 2014-03-12 | 北京元延医药科技有限公司 | Flucloxacillin sodium and amoxicillin sodium composition for injection |
| CN104055771A (en) * | 2013-07-11 | 2014-09-24 | 广州安健实业发展有限公司 | Flucloxacillin sodium/amoxicillin sodium powder injection |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2469179A1 (en) * | 1979-11-08 | 1981-05-22 | Beecham Group Ltd | PHARMACEUTICAL COMPOSITION FOR INJECTION CONTAINING A PENICILLIN |
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2009
- 2009-02-12 CN CN2009100076298A patent/CN101474176B/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103330711A (en) * | 2013-07-11 | 2013-10-02 | 广州安健实业发展有限公司 | Flucloxacillin sodium and amoxicillin sodium for injection |
| CN104055771A (en) * | 2013-07-11 | 2014-09-24 | 广州安健实业发展有限公司 | Flucloxacillin sodium/amoxicillin sodium powder injection |
| CN104055771B (en) * | 2013-07-11 | 2016-10-05 | 广州安健实业发展有限公司 | Flucloxacillin sodium and amoxicillin sodium powder ampoule agent for injection |
| CN103622956A (en) * | 2013-12-16 | 2014-03-12 | 北京元延医药科技有限公司 | Flucloxacillin sodium and amoxicillin sodium composition for injection |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101474176B (en) | 2010-08-18 |
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Owner name: HAINAN MEILAN SHIKE PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: HAINAN BENCHUANG PHARMACEUTICAL TECHNOLOGY CO., LTD. Effective date: 20130826 |
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Free format text: CORRECT: ADDRESS; FROM: 570125 HAIKOU, HAINAN PROVINCE TO: 570216 HAIKOU, HAINAN PROVINCE |
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| TR01 | Transfer of patent right |
Effective date of registration: 20130826 Address after: 6, No. 570216, Haikou Free Trade Zone, 168 Nanhai Avenue, Hainan, Haikou Patentee after: Hainan Meilan Shike Pharmaceutical Co., Ltd. Address before: The new business building No. 48 570125 Hainan city of Haikou province China World Trade Center Road, room 2601 Patentee before: Hainan Benchuang Pharmaceutical Technology Co., Ltd. |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100818 Termination date: 20160212 |