CN101473263B

CN101473263B - Wettable silicone hydrogel contact lenses and related compositions and methods

Info

Publication number: CN101473263B
Application number: CN2007800223506A
Authority: CN
Inventors: 查理·陈; 洪叶; 尼克·马内西斯
Original assignee: CooperVision International Holding Co LP
Current assignee: Cooper optics International Ltd.
Priority date: 2006-06-15
Filing date: 2007-06-12
Publication date: 2011-01-05
Anticipated expiration: 2027-06-12
Also published as: CN101467093A; CN101467094B; CN101473263A; CN101467093B; CN101467094A

Abstract

Silicone hydrogel contact lenses having ophthalmically acceptable surface wettabilities are obtained from pre-extracted polymerized silicone hydrogel contact lens products having relatively large amounts of removable or extractable materials. The silicone hydrogel contact lenses can be obtained from non-polar resin based contact lens molds and without surface treatments or an interpenetrating polymeric network of a polymeric wetting agent. Related lens products, polymerizable compositions, and methods are also described.

Description

Wettable silicone hydrogel contact lenses and compositions related and method

The CROSS-REFERENCE TO RELATED APPLICATIONS case

The application's case is advocated the U.S. patent application case the 60/804th of application on June 15th, 2006, the U.S. patent application case the 60/887th of application on January 31st, No. 911 1, the U.S. patent application case the 60/894th of application on March 13rd, No. 513 1, the U.S. patent application case the 11/761st of No. 609 and on June 11st, 2007 application, No. 272 right, each described application case all is that way of reference is incorporated herein in full.

Technical field

The present invention is especially at silicone-hydrogel Ophthalmoligic instrument and compositions related and method.More particularly, the present invention relates to through molded Wettable silicone hydrogel contact lenses and compositions related and method.

Background technology

Silicone hydrogel contact lens is universal, and this is that contact lens wear person wears the ability of described glasses last much longer on its eyes owing to compare with non-silicone hydrogel contact lens.For instance, decide on specific glasses, silicone hydrogel contact lens can be worn through every day, wears weekly, two week wears or wore in every month and wear and tear or be defined as wear every day, wear weekly, two week wears or wore in every month.Relevant with the silicone hydrogel contact lens benefit to lens wearer can to small part owing to the water wettability component of the silicon-containing polymer matter of contact lenses and the combination of hydrophobic property.

Produce in non-silicone hydrogel contact lens (such as hydrogel contact lens) the non-polar resin contact lens molds of being everlasting (for example contact lens molds that produces by polyolefin resin) based on methacrylic acid 2-hydroxyl ethyl ester (HEMA).The glasses precursor composition that is used for non-silicone hydrogel contact lens in the polymerization of non-polar resin contact lens molds to produce polymerization glasses product based on HEMA.Because it is based on the hydrophilic nmature of the polymerization component of the contact lenses of HEMA,, still compatible and have eye with acceptable surperficial wettable on eyes based on the glasses of HEMA even although use the non-polar resin mould to produce.

By contrast, the existing silicone hydrogel contact lens that is obtained from the non-polar resin mould has the hydrophobicity lens surface.In other words, the surface of described silicone hydrogel contact lens has low moisture adsorbability, and therefore incompatible or do not accepted by eyes on eyes.For instance, described silicone hydrogel contact lens can be relevant with more unfavorable feature, described feature such as the lipidosis that increases, proteins deposited, glasses and ocular surface combine and to the generally stimulation of lens wearer.

Making great efforts to overcome in the process of these problems, attempting adopting silicone hydrogel contact lens or glasses product are carried out surface treatment or surface modification to increase the water wettability and the wettable of lens surface.The surface-treated example of silicone-hydrogel glasses comprises the coating lens surface, chemical substance is adsorbed on the lens surface, and changes the chemical property or the electrostatic charge of chemical group on the lens surface.Described surface treatment, it comprises use plasma gas coating polymerization lens surface, or uses plasma gas to form the polymerization glasses then to handle mould on the contact lens molds surface.Unfortunately, some shortcomings are relevant with the method.Compare with the manufacture method of not using surface treatment or modification, the surface treatment of contact lenses needs more that multimachine tool and time produce contact lenses.In addition, when glasses were worn and/or touched by lens wearer, surface treated silicone hydrogel contact lens can be showed the surperficial wettable of minimizing.For instance, the touch that increases surface treated glasses can cause hydrophilic surface degradation or wearing and tearing.

The wettable of another kind of increase silicone-hydrogel glasses and the method for eyes compatibility are polymerization silicone hydrogel contact lens precursor composition in the presence of second composition that comprises polymerization wetting agent (such as polyvinylpyrrolidone (PVP)).The glasses of described type are referred to herein as the silicone hydrogel contact lens with the inner wetting agent of polymerization, and comprise the interpenetrating polymer network (IPN) that comprises heavy polymer (such as PVP) usually.Understand as one of ordinary skill in the art, IPN is meant the combination of two or more different polymkeric substance with latticed form, and wherein at least a polymkeric substance is synthetic and/or crosslinked in the presence of another kind of polymkeric substance, does not have any covalent bond between the two.IPN can form two independences but adjoins or the chain of the network of IPN is formed by two kinds.The example of IPN comprises substep IPN, synchronous IPN, half IPN and equal IPN.Avoid the problem relevant with surface treatment though comprise the silicone hydrogel contact lens of polymerization wetting agent IPN, the time that described glasses last prolongation may still can't keep its eyes compatibility, comprises surperficial wettable.For instance, because inner wetting agent is other component of covalent bond formation polymerization glasses not, therefore when being worn by lens wearer, it may leach from glasses, thereby and passing in time causes surperficial wettable to reduce and the sense of discomfort of lens wearer increases.

As aforesaid surface treatment or use the alternative of polymerization wetting agent IPN, found to use polar resin molds to replace the non-polar resin mould to produce to have eye with the wettable silicone hydrogel contact lens in acceptable surface.For instance, the silicone hydrogel contact lens that forms in ethylene-vinyl alcohol radical or PVA-based mould has required surperficial wettable.An example that is applicable to the polar resin of the contact lens molds of making the not surface treated silicone hydrogel contact lens be used to produce no polymerization wetting agent IPN is the ethylene-vinyl alcohol copolymer resin, such as (Nippon Gohsei is Ltd) with brand name Suo Lite (SOARLITE) by The Nippon Synthetic Chemical Industry Co., Ltd ^TMThe ethylene-vinyl alcohol copolymer resin of selling.Except that its polarity, Suo Lite ^TMBe described as having following feature: high physical strength, antistatic behaviour, the low-shrinkage when being used for molding process, good oil-proofness and solvent resistance, little thermal expansivity and excellent abrasive resistance.

Though based on Suo Lite ^TMMould provide favourable alternative under the situation of not using surface treatment or polymerization wetting agent IPN, producing the compatible silicone hydrogel contact lens of eyes, but Suo Lite ^TMDeformability that mould is compared with non-polar resin mould (such as polypropylene molds) or flexibility are less, and compare relative difficult with operation with the non-polar resin mould.

According to above, as seen need the compatible silicone hydrogel contact lens of eyes, its with by Suo Lite ^TMThe silicone hydrogel contact lens that contact lens molds obtains is compared and is easier to produce, and need not surface treatment or use polymerization wetting agent IPN (comprising PVP IPN) to reach the eyes compatibility.In addition, very need to provide a kind of method from non-polar resin or the polyolefin-based contact lens molds member generation compatible silicone hydrogel contact lens of eyes (such as having the wettable silicone hydrogel contact lens in the compatible surface of eyes), described method overcomes the shortcoming of existing manufacture method.That is to say, need a kind of modification method that is used to prepare the compatible silicone hydrogel contact lens of eyes, it both need not surface treatment gained contact lens product, also need not to use polymerization wetting agent IPN to provide the product of the glasses with the feature that helps long-term comfort as the part of polymerizable silicone hydrogel contact lens precursor composition.The present invention satisfies these needs.

Summary of the invention

Contact lenses of the present invention, glasses product, composition and method solve needs and the problem relevant with its present production method with having silicone hydrogel contact lens now.Find that shockingly the compatible silicone hydrogel contact lens of eyes is to provide the polymerisable compound of the extraction pre-polymerization silicone hydrogel contact lens product with one or more features that especially need to obtain by making up some component after being provided at polymerization.In one or more embodiments, before extraction, the hydrogel contact lens product has about 10 weight % or more can extract component.In certain embodiments, the extractable of the silicone hydrogel contact lens product before the extraction is at least about 20 weight %.For instance, the silicone hydrogel contact lens product before the extraction can have the extractable of about 22 weight % to about 30 weight %.In at least one specific embodiment, the silicone hydrogel contact lens product before the extraction has the extractable of about 26 weight %.In one or more embodiment of product of the present invention and method, this paper provides a kind of silicone hydrogel contact lens product, it does not adopt polyalkylene oxidation silicon can extract component, but it advantageously causes comparing with existing glasses and has different and need combination of features thing and glasses.

The feature of the silicone hydrogel contact lens that this paper provided comprises that eye as described herein is with accepting surperficial wettable.In addition, silicone hydrogel contact lens of the present invention has oxygen permeability, surperficial wettable, modulus, liquid water content, ion flow and design, it makes glasses of the present invention be fit to the period that patient's eye is cosily worn prolongation, such as at least one sky, at least one week, at least two weeks or about one month, and need not to remove glasses from eyes.

On the one hand, the present invention is directed to a kind of polymerizable silicone hydrogel contact lens precursor composition.Described precursor composition forms silicone hydrogel contact lens effectively.

In a particular aspects, this paper provides a kind of polymerisable compound, and it comprises following component, is formed or be made up of it fully by it basically: α-ω-two (methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyl)-poly-(dimethyl siloxane)-poly-(trifluoro propyl methylsiloxane)-poly-(ω-methoxyl-poly-(ethylene glycol) propyl group methylsiloxane), N-vinyl-N-methylacetamide, methyl methacrylate, Ethylene glycol dimethacrylate, the pure and mild radical initiator of allyloxy.

In one or more embodiments, polymerisable compound further comprises ultraviolet light absorber, such as 2-hydroxyl-4-acryloxy oxethyl-diphenyl-ketone.

In one or more other embodiment, polymerisable compound further comprises colorant, and phthalocyanine color for example is such as phthalocyanine blue.

In one or more other embodiment, the radical initiator that is comprised in the polymerisable compound is 2,2 '-azoisobutyronitrile.

The present invention further comprises any one or the many persons in the above-described polymerisable compound, and it comprises α-ω-two (methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyls)-poly-(dimethyl siloxane)-poly-(trifluoro propyl methylsiloxane)-poly-(ω-methoxyl-poly-(ethylene glycol) propyl group methylsiloxane) of about 34 weight %.

In one or more other embodiment, polymerisable compound can comprise any one or the many persons in following: (i) N-vinyl-N-methylacetamide of about 46 weight %, (ii) methyl methacrylate, the (iii) Ethylene glycol dimethacrylate of about 0.5 weight % and the allyloxy alcohol of (iv) about 1 weight % of about 17 weight %.

In one or more other embodiment, polymerisable compound comprises 2-hydroxyl-4-acryloxy oxethyl-diphenyl-ketone of about 0.9 weight %.

In one or more other embodiment, polymerisable compound comprises the phthalocyanine blue of about 0.1 weight %.

In one or more other embodiment, polymerisable compound comprises the radical initiator of about 0.3 weight %.

In another specific embodiment, polymerisable compound comprises α-ω-two (methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyls)-poly-(dimethyl siloxane)-poly-(trifluoro propyl methylsiloxane)-poly-(ω-methoxyl-poly-(ethylene glycol) propyl group methylsiloxane) of 34 weight %, N-vinyl-N-methylacetamide of about 46 weight %, the methyl methacrylate of about 17 weight %, the Ethylene glycol dimethacrylate of about 0.5 weight %, the allyloxy alcohol of about 1 weight %, the 2-hydroxyl of about 0.9 weight %-4-acryloxy oxethyl-diphenyl-ketone, 2,2 of the phthalocyanine blue of about 0.1 weight % and about 0.3 weight % '-azoisobutyronitrile.

In another embodiment, provide any one or the many persons who does not contain in the polymerisable compound that polyalkylene oxidation silicon can extract component as herein described.

In another aspect, provide a kind of by the silicone hydrogel contact lens that produces as the polymerisable compound that this paper provided.

Also provide a kind of and do not have the formed silicone hydrogel contact lens of the polymerisable compound that can extract component in fact by as described herein.

Also constitute part person of the present invention for a kind of by silicone hydrogel contact lens that following steps produced: polymerization such as the polymerisable compound that this paper provided comprise the extraction pre-polymerization silicone hydrogel contact lens that can extract component with formation, extraction can extract component with the polymerization glasses product of formation through extraction the contact lenses before extracting, and the polymerization glasses product water through extraction is closed to form silicone hydrogel contact lens.

In one or more embodiments, the silicone hydrogel contact lens that produces as mentioned above has equilibrium water content and the oxygen permeability (D in about 80-110 Barre scope to about 50 weight % scopes at about 42 weight % _k* 10 ^-11).

In one or more other embodiment, the silicone hydrogel contact lens of Chan Shenging has about modulus of 0.6 to about 1.2MPa as mentioned above.

In one or more other embodiment, a kind of silicone hydrogel contact lens that produces as mentioned above is provided, wherein polymerization procedure comprises polymerisable compound is heated to greater than about 65 ℃ temperature.

In another aspect, this paper provide a kind of equilibrium water content about 42 weight % to about 50 weight % scopes, oxygen permeability (D _k* 10 ^-11) in about 80-110 Barre scope, modulus be about 0.6 to about 1.2MPa, ion flow be about 1-5 (* 10 ^-3Mm ²/ min), advancing contact angle be about 52 ° to about 62 °, receding contact angle be about 40 ° to 60 ° and lag behind for about 5 ° to about 15 ° silicone hydrogel contact lens.

In one or more embodiments, silicone hydrogel contact lens as described herein is characterized by the mirror body with circular circumference edge in addition.

In one or more other embodiment, silicone hydrogel contact lens of the present invention can be: (i) sphere glasses, (ii) aspheric surface glasses, (iii) single focus glasses, (iv) multifocal spectacles or (v) spin stabilization toric contact lens.

In one or more other embodiment, in silicone hydrogel contact lens of the present invention is in and packs.

In one or more other embodiment, as silicone hydrogel contact lens that this paper provided without surface treatment.

In another aspect, this paper provides a kind of method that produces polymerizable silicone hydrogel contact lens precursor composition.In one or more embodiments, described method comprises combination α-ω-two (methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyls)-poly-(dimethyl siloxane)-poly-(trifluoro propyl methylsiloxane)-poly-(ω-methoxyl-poly-(ethylene glycol) propyl group methylsiloxane), N-vinyl-N-methylacetamide, methyl methacrylate, Ethylene glycol dimethacrylate, the pure and mild radical initiator of allyloxy, thereby to produce polymerisable silicone hydrogel contact lens precursor composition.

In one or more embodiment of described method, combination step comprises ultraviolet light absorber in addition.

In one or more specific embodiments, combination step comprises 2-hydroxyl-4-acryloxy oxethyl-diphenyl-ketone in addition.

In one or more other embodiment of described method, combination step comprises colorant in addition, and phthalocyanine color for example is such as phthalocyanine blue.

In one or more specific embodiments of described method, radical initiator is 2,2 '-azoisobutyronitrile.

In one or more specific embodiments, described method comprises following each thing of combination:

(i) α-ω of about 30 weight % to 40 weight %-two (methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyls)-poly-(dimethyl siloxane)-poly-(trifluoro propyl methylsiloxane)-poly-(ω-methoxyl-poly-(ethylene glycol) propyl group methylsiloxane),

N-vinyl-N-methylacetamide of (ii) about 40 weight % to 50 weight %,

The methyl methacrylate of (iii) about 10 weight % to 25 weight % and

(iv) less than the Ethylene glycol dimethacrylate of about 5 weight %, allyloxy alcohol, 2-hydroxyl-4-acryloxy oxethyl-diphenyl-ketone, phthalocyanine blue and 2,2 '-combination of azoisobutyronitrile.

In one or more other embodiment of described method, combination step comprises α-ω-two (methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyls)-poly-(dimethyl siloxane)-poly-(trifluoro propyl methylsiloxane)-poly-(ω-methoxyl-poly-(ethylene glycol) propyl group methylsiloxane) that makes up about 34 weight %, N-vinyl-N-methylacetamide of about 46 weight %, the methyl methacrylate of about 17 weight %, the Ethylene glycol dimethacrylate of about 0.5 weight %, the allyloxy alcohol of about 1 weight %, the 2-hydroxyl of about 0.9 weight %-4-acryloxy oxethyl-diphenyl-ketone, 2 of the phthalocyanine blue of about 0.1 weight % and about 0.3 weight %, 2 '-azoisobutyronitrile, thereby so that polymerisable silicone hydrogel contact lens precursor composition to be provided.

In one or more other embodiment, described method further comprises polymerization polymerizable glasses precursor composition to form the preceding polymerization silicone hydrogel contact lens of extraction.

In one or more specific embodiments of described method, polymerization procedure comprises heating polymerizable glasses precursor composition.

In one or more other embodiment, described method is positioned over polymerizable glasses precursor composition in the non-polar resin contact lens molds before further being included in polymerization procedure.

In one or more other embodiment, described method further comprise to the polymerization contact lenses before extracting implement extraction with form do not exist in fact can extract component through extraction polymerization glasses product, and the polymerization glasses product water through extraction is closed to form silicone hydrogel contact lens.

In another aspect, this paper provides a kind of silicone hydrogel contact lens, and it comprises the reaction product of not having the polymerisable compound that can extract component in fact as described herein.

Other embodiment of glasses of the present invention, glasses product, composition and method is apparent by following description, icon, example and claims.As understanding by above and following description, as herein described each includes in category of the present invention with each combination with both or both above each in each feature and the described feature, and its restrictive condition is feature included in a described combination unanimity each other.In addition, but any feature or characteristics combination given row except that any embodiment of the present invention.Especially when considering in conjunction with enclose example and icon, others of the present invention and advantage are illustrated in following embodiment and claims.

Description of drawings

Fig. 1 produces the calcspar of the exemplary methods of silicone hydrogel contact lens for explanation.

Fig. 2 is the calcspar of explanation composition of the present invention, glasses product and contact lenses.

Embodiment

The present invention now will more fully describe hereinafter.Yet the present invention is can be multiple multi-form to be specialized, and should not be construed as and be limited to the embodiment that this paper proposes; On the contrary, provide described embodiment so that this disclosure is detailed and complete, and pass on category of the present invention fully the those skilled in the art.

Definition

Must note, unless context clearly indication in addition, otherwise as singulative used in this instructions " " and " as described in " comprise plural indicant.Therefore, for instance, mention that " contact lenses " comprise single glasses and two or more identical or different glasses, mention that " precursor composition " is meant single composition and two or more identical or different composition or the like.

Describing and advocating that when of the present invention, following term will use according to definition hereinafter described.

As used herein term " hydrogel " be meant be generally polymer chain network or matrix can in water, expand or through water swellable polymeric material.Network or matrix crosslinkable or can be not crosslinked.Hydrogel is meant that to meet water inflatable or through water swellable polymeric material, comprises contact lenses.Therefore, hydrogel can (i) without hydration and to meet water inflatable, or (ii) partially hydrated and expand, or (iii) hydration and expand fully through water through water.

" be substituted " part (for example alkyl) that is meant through one or more non-interfering substituent replacements as the term in (for example) " alkyl that is substituted ", described substituting group is such as (but being not limited to) C ₃-C ₈Naphthenic base (for example cyclopropyl, cyclobutyl etc.), halogen (for example fluorine-based, chloro, bromo and iodo), cyano group, alkoxy, low-carbon (LC) phenyl, phenyl of being substituted etc.For the replacement on the phenyl ring, substituting group can be in office where (that is to say in ortho position, a position or contraposition) gone up in the position.

Term " silicone-hydrogel " or " silicone-hydrogel material " are meant the specific hydrogel that comprises silicon (Si) component or silica component.For instance, silicone-hydrogel is normally by preparing silicon-containing material and conventional hydrophilic hydrogel combination of precursors.Silicone hydrogel contact lens is the contact lenses that comprise the silicone-hydrogel material, comprises the contact lenses of correcting defects of vision.The characteristic of silicone hydrogel contact lens is different from conventional hydrogel based glasses.

" contain the silica component " for contain the component of at least one [Si-O-Si] binding in monomer, macromonomer or prepolymer, wherein each silicon atom can have one or more organic group substituting group (R that can be identical or different according to circumstances ₁, R ₂) or the organic group substituting group that is substituted, for example-SiR ₁R ₂O-.

" optional " or " according to circumstances " meaning is that described subsequently incident may take place or may not can take place, so that this description comprises the situation that situation that incident takes place and incident do not take place.

" molecular mass " under the situation of polymkeric substance of the present invention is meant the nominal average molecular mass of polymkeric substance, usually by size exclusion chromatography (SEC), light scattering technique or 1,2, the inherent velocity determination method in the 4-trichloro-benzenes is measured.Molecular weight under the polymkeric substance situation can be expressed as number average molecular weight or weight average molecular weight, and under the situation of the material of manufacturer-supplied, will decide on the supplier.If be not to provide with the packing material form, the basis of so any described molecular weight determination all can be easy to be provided by the supplier.The macromonomer that common this paper mentions or the molecular weight of polymkeric substance in this article refer to weight average molecular weight.The molecular weight determination of number average molecular weight and weight average molecular weight all can use gel permeation chromatography technology or other liquid chromatography technology to measure.Also can use other to measure the method for molecular weight values, measure number average molecular weight such as use end-group analysis or measurement colligative property (for example solidifying point decline, the elevation of boiling point or osmotic pressure), or use light scattering technique, supercentrifugation or viscosimetry to come the gravimetry mean molecular weight.

" network " of hydrophilic polymer or " matrix " usually the meaning be between polymer chain by covalent bond or secondary or physical bond (for example hydrogen bond) form crosslinked.

" water wettability " material is the happiness aqueous substance.Described compound has affinity and normal charged or have a polar side chain group that attracts water to glassware for drinking water.

" hydrophilic polymer " of the present invention is defined as and can expands in water but polymkeric substance not necessarily soluble in water.

" water wettability component " is for can be or can not being the hydroaropic substance of polymkeric substance.When being included in and making up with the remaining reaction component, the water wettability component can provide those water wettability components to gained hydration glasses at least about the liquid water content of 20% (for example at least about 25%).

" silicone hydrogel contact lens that eyes are compatible " is meant and can wears on human eye and the people can not experience or report the silicone hydrogel contact lens of significantly uncomfortable (comprising eye irritation etc.) as used herein.The compatible silicone hydrogel contact lens of eyes has eye with can accepting surperficial wettable, and can not cause or follow remarkable cornea swelling usually, corneal dehydration (" scheroma "), the arciform pathology of top corneal epithelium (" SEAL ") or other significant discomfort.

" in fact " or " basically " or " pact " meaning be almost all or fully, for example more than 95% of a certain specified rate or 95%.

" do not exist in fact " or " not having in fact " a certain feature or the entity meaning is almost all or fully not have described feature or entity, for example contain 5% or be less than some given entity of 5%.For instance, the composition that does not have a certain entity in fact can contain be less than about 5% or be less than about 4%, be less than about 3%, be less than about 2% or even less than some given entity of about 1%.

" alkyl " is meant the length hydrocarbon chain in about 1 to 20 atoms range usually.Described hydrocarbon chain is preferable but might not be saturated, though and straight chain is preferable usually, can be side chain or straight chain.Exemplary alkyl comprises methyl, ethyl, propyl group, butyl, amyl group, 1-methyl butyl, 1-ethyl propyl, 3-methyl amyl etc.When mentioning three or three above carbon atoms, " alkyl " comprises naphthenic base as used herein.

" oligomer " is the molecule of being made up of a limited number of monomer subunits, and forms to about 8 monomer subunits by about 2 usually.

" low-carbon alkyl " is meant the alkyl that contains 1 to 6 carbon atom, and can be straight or branched, for example methyl, ethyl, normal-butyl, isobutyl, the tert-butyl group.

Other definition also is found in in the lower part.

Summary

As discussed previously, the present invention provided herein to small part based on following discovery/composite, that is: can use the problem of avoiding relevant with polar resin molds, avoid the needs of program and the method for solution and polymerization wetting agent IPN relevant issues after the complicated and expensive polymerization are prepared the compatible silicone hydrogel contact lens of eyes.In addition, the composite that this paper provided need not to surpass about 30% remove maybe and can extract component, and described component is not incorporated into basically in the polymerization silicone hydrogel contact lens product and by extraction and removed through molded contact lens product from gained with other unreacted component.For instance, the compatible silicone hydrogel contact lens of eyes can be from having at least 10% and obtain less than about 30% the extraction pre-polymerization silicone hydrogel contact lens product through the extracted inclusions of the silicone hydrogel contact lens of dehydration extraction as discussed herein.In certain embodiments, the glasses composite does not have polyalkylene oxidation silicon component.

Specifically, the method that produces the compatible silicone hydrogel contact lens of eyes comprises the particular combinations of component is incorporated in the polymerizable silica contact lenses precursor composition.Described material gives the final contact lenses of gained required feature, thereby the contact lens product through extraction is provided, then its hydration is had eye with the final silicone hydrogel contact lens that can accept surperficial wettable and other useful feature as described herein with generation

Describing in detail and illustration these and other importance of the present invention with the lower part.

The component of polymerizable silicone hydrogel contact lens precursor composition

Silicone hydrogel contact lens of the present invention is called the material of " polymerizable silicone hydrogel contact lens precursor composition " or " precursor composition " by this paper usually and produces.Precursor composition is the potpourri in order to all ingredients of preparation silicone hydrogel contact lens, just at reaction (being polyreaction under situation of the present invention) preceding reaction mixture.

Precursor composition of the present invention comprises following at least component: α-ω-two (methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyl)-poly-(dimethyl siloxane)-poly-(trifluoro propyl methylsiloxane)-poly-(ω-methoxyl-poly-(ethylene glycol) propyl group methylsiloxane), N-vinyl-N-methylacetamide, methyl methacrylate, Ethylene glycol dimethacrylate, the pure and mild radical initiator of allyloxy usually.In certain embodiments, composition is made up of aforementioned component basically.In other embodiments, composition is made up of aforementioned component fully.

α-ω-two (methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyl)-poly-(dimethyl siloxane)-poly-(trifluoro propyl methylsiloxane)-poly-(ω-methoxyl-poly-(ethylene glycol) propyl group methylsiloxane)

First component α-ω-two (methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyl)-poly-(dimethyl siloxane)-poly-(trifluoro propyl methylsiloxane)-poly-(ω-methoxyl-poly-(ethylene glycol) propyl group methylsiloxane) is reactive fluorine-containing acryloyl group silica macromonomer, is commonly referred to as " M3U " (the CAS accession number is 697234-74-5).Shown in following universal architecture, described macromonomer is a triblock copolymer, that is to say to comprise three kinds of different siloxane polymer blocks.Central block has trifluoromethyl substituent, and acryloyl group partly is present in each end.

Variable n, m and h be corresponding to the number of repeating units of each block, and independently of one another about 3 to about 200 scope, and p (ethylene oxide number of repeating units) about 2 to about 12 scope.Corresponding to a kind of especially preferable macromonomer of above structure be wherein n in 50 to 200 scope, m is in 2 to 50 scope and the macromonomer of h in 1 to 15 scope.One especially in the preferred embodiment, n is about 121, and m is about 7.6, and h is about 4.4, and p is about 7.4.M3U can be easy to synthesize according to the program that proposes in open No. 2006/026474 example 1 of case WO of international monopoly.

The value of apparent variable n, m, h and p and deciding, the molecular weight of silica macromonomer component (M3U just) usually about 8,000 dalton (dalton) to about 25, in the 000 daltonian scope, and preferable about 10,000 dalton to about 20, the 000 daltonian scopes.A kind of especially preferable siloxane macromer that is used for the present invention has about 16,000 daltonian molecular weight.For instance, macromonomer can have about 16,200 daltonian weight average molecular weights (Mw) and about 12,800 daltonian number average molecular weights (Mn).

The polymerizable silicone-hydrogel precursor composition that this paper provides contains α-ω-two (methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyls)-poly-(dimethyl siloxane)-poly-(trifluoro propyl methylsiloxane)-poly-(ω-methoxyl group-PEG propyl group methylsiloxane) at least about 25 % by weight usually, and better α-ω-two (methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyls)-poly-(dimethyl siloxane)-poly-(trifluoro propyl methylsiloxane)-poly-(ω-methoxyl group-PEG propyl group methylsiloxane) that contains at least about 30 % by weight. Even more preferably; polymerisable compound of the present invention contains the 25 weight % that have an appointment to α-ω-two ( the methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyls ) of about 40 weight %-poly- ( dimethyl siloxane )-poly- ( trifluoro propyl methylsiloxane )-poly- ( ω-methoxyl-poly- ( ethylene glycol ) propyl group methylsiloxane ) , or best α-ω-two ( methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyls )-poly- ( dimethyl siloxane )-poly- ( trifluoro propyl methylsiloxane )-poly- ( ω-methoxyl-poly- ( ethylene glycol ) propyl group methylsiloxane ) of 30 weight % to about 40 weight % of having an appointment that contain.A kind of especially preferable polymerisable compound comprises α-ω-two ( methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyls )-poly- ( dimethyl siloxane )-poly- ( trifluoro propyl methylsiloxane )-poly- ( ω-methoxyl-poly- ( ethylene glycol ) propyl group methylsiloxane ) of about 34 weight %.

N-vinyl-N-methylacetamide

Comprise N-vinyl-N-methylacetamide (VMA) in addition as the polymerisable compound that this paper provided, a kind of water wettability contains vinyl (CH ₂=CH-) monomer.The structure of VMA is corresponding to CH ₃C (O) N (CH ₃)-CH=CH ₂

Other water wettability vinyl-containing monomers that can incorporate in the glasses material of the present invention comprises following each thing: N-vinyl lactam (for example N-vinyl pyrrolidone (NVP)), N-vinyl-N-ethyl acetamide, N-vinyl-N-ethyl-formamide, N-vinyl formamide, carbamic acid N-2-hydroxyethyl vinyl acetate, N-carboxyl-Beta-alanine N-vinyl acetate.

N-vinyl-N-methylacetamide is preferable to be present in the polymerisable compound to the amount in order in the precursor composition scope of preparation silica glasses product of about 55 weight % with about 35 weight %, and even goodly exists to the amount in the precursor composition scope of about 50 weight % with about 40 weight %.The representative weight of N-vinyl-N-methylacetamide comprises following each weight: the precursor composition of about 40 weight %, 41 weight %, 42 weight %, 43 weight %, 44 weight %, 45 weight %, 46 weight %, 47 weight %, 48 weight %, 49 weight % or 50 weight %.In a preferred embodiment, comprise N-vinyl-N-methylacetamide of about 46 weight % as the polymerisable compound that this paper provided.

Methyl methacrylate (MMA)

The polymerizable precursors composition that is used to prepare silicone hydrogel contact lens product of the present invention comprises acrylic monomer in addition, such as methyl methacrylate.

Methyl methacrylate is preferable to be existed to the amount in order in the precursor composition scope of preparation silicone-hydrogel glasses product of about 25 weight % with about 10 weight %, and even goodly exists to the amount in the precursor composition scope of about 22 weight % with about 10 weight %.In whole precursor composites, the representative percentage by weight of methyl methacrylate comprises following each percentage by weight: about 10 weight %, 11 weight %, 12 weight %, 13 weight %, 14 weight %, 15 weight %, 16 weight %, 17 weight %, 18 weight %, 19 weight %, 20 weight %, 21 weight %, 22 weight %, 23 weight %, 24 weight % and 25 weight %.

Ethylene glycol dimethacrylate (EGDMA)

Precursor composition comprises the ethylene oxide oligomer of acrylate functional in addition, that is to say to have about 1 to about 8 continuous ethylene oxide (CH ₂CH ₂O-) monomer subunits and terminal through the functionalized ethylene oxide oligomer of reactive group (such as acrylate-based).The ethylene oxide oligomer of acrylate functional is preferably an ethylene oxide monomer or an aggressiveness (1-mer), and is equal difunctionality, that is to say at each end through methacrylate based end-blocking.Universal architecture is provided in hereinafter, and wherein variable s is corresponding to the number of ethylene oxide monomer.

In above structure, s generally between 1 to about 8, is preferably 1 to about 4.That is to say that the preferred values of s comprises 1,2,3,4,5,6,7 and 8.The ethylene oxide oligomer of acrylate functional is preferably the ethylene oxide dimethylacrylate, and wherein s has value 1.

The ethylene oxide oligomer (that is to say EGDMA) of acrylate functional is present in the precursor composition with relatively little amount usually.For instance, oligomer is present in the precursor composition to about 10 weight %, the preferable about 0.075 weight % amount to about 5 weight % scopes with about 0.05 weight %.The representativeness amount of EGDMA component comprises following amount: the precursor composition of about 0.1 weight %, 0.2 weight %, 0.3 weight %, 0.4 weight %, 0.5 weight %, 0.8 weight %, 0.9 weight %, 1 weight %, 2 weight %, 3 weight %, 4 weight % or 5 weight %.In a preferred embodiment, precursor composition of the present invention comprises the EGDMA of about 0.5 weight %.

Allyloxy alcohol

Except that above-mentioned, polymerisable compound of the present invention comprises chain transfer agents.The reagent of chain transfer agents for promoting to react between free radical material and the non-free radical material.Preferable to be used for chain transfer agents of the present invention be allyloxy compound, that is to say the compound that comprises one or more allyloxys parts.The exemplary chain transfer agents that belongs to this type of comprises allyloxy alcohol.Chain-transferring agent can use individually or with form of mixtures.

The compound that comprises at least one allyloxy part has following universal architecture:

Wherein add box part corresponding to the allyloxy part, and Q represents the residue or the residue of parent molecule, for example alcohol or any organic molecule when itself and allyloxy partly link together, can serve as chain-transferring agent.The preferable derive from alcohol of Q is such as ethanol, propyl alcohol, butanols etc. or its form that is substituted.Q is preferably the residue of ethanol, and has structure (CH ₂CH ₂OH), so that chain transfer agents corresponding to the 2-allyloxyethanol.

It has been observed by the present inventors that, comprise that chain transfer agents (such as allyloxy compound) can provide effectively that size and physical property variability reduce through extraction hydration silica contact lenses body.Therefore, add chain-transferring agent in order to " normalization " or " fine setting " precursor glasses composition, so that gained has minimizing changeability between each batch of any one or more following feature usually through extracting hydration contact lenses colony: equilibrium water content, oxygen permeability, static contact angle, dynamic contact angle (advancing contact angle or receding contact angle), hysteresis, refractive index, ion flow, modulus, pulling strengrth etc.

As used herein batch or colony be meant a plurality of contact lenses.Can understand, when the number of contact lenses in contact lenses batch or the colony is enough to significant standard error is provided, reach statistics numerical value through improvement.In some cases, a collection of contact lenses are meant at least 10 contact lenses, at least 100 contact lenses, at least 1000 contact lenses or more.

In general, contain the allyloxy alcohol of 0.1 weight % of having an appointment as the polymerisable compound that this paper provided to about 5 weight %.The preferable allyloxy alcohol of 0.5 weight % of having an appointment that contains of polymerisable compound of the present invention to about 3 weight %.That is to say that polymerisable compound is preferable to contain in the following exemplary percentage by weight of allyloxy alcohol (such as allyloxyethanol) any one: 0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9 or 3 weight %.

Radical initiator

Except that above-mentioned, precursor composition of the present invention comprises one or more initiator compounds usually, that is to say and can cause the precursor composition polymeric compounds.Be preferably thermal initiator, that is to say initiating agent with " polymerization begins " temperature.Have the thermal initiator of higher decomposition starting temperature and use the initiating agent of a small amount of relatively by selection, might reduce the ion flow of glasses of the present invention, thereby can influence the amount of substance removed of in extraction step, removing or extracting.For instance, adoptable a kind of exemplary thermal initiator is

Its corresponding to 2,2 '-azoisobutyronitrile (AIBN), can be available from Du Pont (DuPont) (Wilmington,State of Delaware, US (Wilmington, DE)).As herein described own

Thermal initiator is all available from Du Pont (DuPont) (Wilmington,State of Delaware, US (Wilmington, DE)), and being applicable in the composition that this paper provides.

Thermal initiator is the azonitrile compound that is substituted, and it is through thermal decomposition, and per molecule produces two free radicals.

The half life period of solution under 64 ℃ is 10 hours.Each

The progression of initiating agent (for example " 64 " in the previous examples) is 10 hours residing Celsius temperatures corresponding to the solution half life period.

Be applicable in the composition that this paper provides other

Initiating agent comprises 2,2 '-azo two (2, the 4-methyl pentane nitrile) (

), 2,2 '-azo two (2-methyl propionitrile) (

) and azoisobutyronitrile (

). Have about 50 ℃ decomposition starting temperature, and

Has about 90 ℃ decomposition starting temperature.Be applicable to that other thermal initiator in the polymerisable compound comprises nitrile, such as 1,1 '-azo two (cyclohexanenitriles) and 2,2 '-initiating agent of azo pair (2-methyl propionitrile) and other type, such as initiating agent available from Sigma's aldrich (SigmaAldrich).

The compatible silicone hydrogel contact lens of eyes can be from comprising the radical initiator of about 0.05 weight % to about 1.0 weight % or preferable about 0.07 weight % to about 0.7 weight % (such as above-mentioned

Initiating agent one) precursor composition obtain.Specifically, the preferable radical initiator that contains 0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5, the 0.6 or 0.7 weight % that has an appointment of precursor composition as described herein.

Other component of silicone hydrogel contact lens precursor composition

Glasses precursor composition of the present invention also can comprise other component, for example ultraviolet ray (UV) absorbing agent or UV radiation or energy absorber and/or colorant.

The UV absorbing agent can be (for example) and show high relatively absorption value in the UV-A of about 320-380 nanometer scope, but more than about 380nm transparent relatively strong UV absorbing agent.Example comprises the dihydroxy benaophenonel of photopolymerizable and the benzotriazole of photopolymerizable, such as 2-hydroxyl-4-acryloxy oxethyl-diphenyl-ketone (with

UV416 is available from cyanogen secret service industry company (Cytec Industries)), the benzotriazole of 2-hydroxyl-4-(2 hydroxy-3-methyl acryloxy) propoxyl group benzophenone and photopolymerizable is (with Nuo Boke (NORBLOC)

7966 available from Nola's nurse section (Noramco)).Be applicable to that other photopolymerizable UV absorbing agent of the present invention comprises that polymerisable alkene is unsaturated triazine, salicylate, the acrylate and its potpourri that replace through aryl.In general, if the UV absorbing agent exists, so to provide corresponding to the precursor composition of about 0.5 weight % amount to the composition of about 1.5 weight %.Especially the preferably comprises the composition of about 0.6 weight % to about 1.0 weight %UV absorbing agents.The illustrative composition can contain the UV absorbing agent of (for example) about 0.5 weight %, 0.6 weight %, 0.7 weight %, 0.8 weight %, 0.9 weight %, 1.0 weight %, 1.1 weight %, 1.2 weight %, 1.3 weight %, 1.4 weight % or about 1.5 weight %.

Precursor composition of the present invention also can comprise colorant, although contain colorized glasses product and transparent glasses product.Colorant is preferably chemically-reactive dyes or the pigment that gained glasses product is effectively provided color.

Chemically-reactive dyes is those dyestuffs with silicone-hydrogel glasses material bond and not bleeding.Exemplary colorant comprises following each thing: and benzene sulfonic acid, 4-(4,5-dihydro-4-((2-methoxyl-5-methyl-4-((2-(sulphur oxygen base) ethyl) sulfonyl) phenyl) azo-3-methyl-5-side Oxy-1 H-pyrazol-1-yl); [the 2-naphthalene sulfonic acids, 7-(acetamido)-4-hydroxyl-3-((4-((sulphur oxygen base ethyl) sulfonyl) phenyl) azo)-]; [5-((4,6-two chloro-1,3,5-triazines-2-yl) amino-4-hydroxy-3-((1-sulfo group-2-naphthyl) azo-2,7-naphthalene-disulfonic acid, trisodium salt]; [copper, 29H, 31H-phthalocyanine base (2-)-N ₂₉, N ₃₀, N ₃₁, N ₃₂)-, sulfo group ((4 ((2-sulphur oxygen base) ethyl) sulfonyl) phenyl) amino) sulfonyl-derivatives] and [2,7-naphthalene sulfonic acids, 4-amino-5-hydroxyl-3, two ((4-((2-(sulphur oxygen base) ethyl) sulfonyl) phenyl) the azo)-tetrasodium salts of 6-].

Being used for especially preferable colorant of the present invention is phthalocyanine color, such as the various ferriferous oxides of phthalocyanine blue and phthalocyanine green, chromium oxide-aluminium oxide-cobalt protoxide, chromium oxide and redness, yellow, brown and black.In general, if adopt, the toner of doing that will account for about 0.05 weight % of composition to about 0.5 weight %, or the preferable about 0.07 weight % of composition that accounts for is to about 0.3 weight %.The illustrative percentage by weight of colorant (for example phthalocyanine color) comprises following weight %:0.05 weight %, 0.06 weight %, 0.07 weight %, 0.08 weight %, 0.09 weight %, 0.1 weight %, 0.2 weight %, 0.3 weight %, 0.4 weight %, 0.5 weight % etc.Also can incorporate opacifying agent into such as titania.Use for some, can adopt the outward appearance of the potpourri of color with better simulating nature iris.

Representative precursor composition comprises α-ω-two (methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyls)-poly-(dimethyl siloxane)-poly-(trifluoro propyl methylsiloxane)-poly-(ω-methoxyl-poly-(ethylene glycol) propyl group methylsiloxane) of about 30 weight % to 40 weight %, N-vinyl-N-methylacetamide of about 40 weight % to 50 weight %, the methyl methacrylate of about 10 weight % to 25 weight % and the Ethylene glycol dimethacrylate that is less than about 5 weight %, allyloxy alcohol, 2-hydroxyl-4-acryloxy oxethyl-diphenyl-ketone, phthalocyanine blue and 2,2 '-combination of azoisobutyronitrile, that is to say by making up above component to produce.

Exemplary precursor composition is provided in the example 1.One especially in the preferred embodiment, polymerisable compound can comprise each following component of following amount (in weight %), basically form or form by it fully by it: α-ω of about 34 weight %-two (methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyl)-poly-(dimethyl siloxane)-poly-(trifluoro propyl methylsiloxane)-poly-(ω-methoxyl-poly-(ethylene glycol) propyl group methylsiloxane), N-vinyl-N-methylacetamide of about 46 weight %, the methyl methacrylate of about 17 weight %, the Ethylene glycol dimethacrylate of about 0.5 weight %, the allyloxy alcohol of about 1 weight %, the 2-hydroxyl of about 0.9 weight %-4-acryloxy oxethyl-diphenyl-ketone, 2,2 of the phthalocyanine blue of about 0.1 weight % and about 0.3 weight % '-azoisobutyronitrile.

The polymerizable silicone hydrogel contact lens precursor composition that is provided in the non-polar resin contact lens molds is provided some embodiment of precursor composition of the present invention.Other embodiment is included in the storage container (such as bottle etc.) or the described composition in the distributor (such as artificial or automatic pipetting device).

Form the method for silicone hydrogel contact lens

In general, when producing silicone hydrogel contact lens, the component of silicone hydrogel contact lens precursor composition is weighed and then combination separately.Then (for example) uses magnetic force or mechanical mixture to mix the gained precursor composition usually, and filters according to circumstances to remove particulate.

Glasses of the present invention can (for example) produce as illustrated in fig. 1.

Fig. 1 produces the calcspar of the method for silicone hydrogel contact lens for explanation.Specifically, Fig. 1 illustrates a kind of method of injection molding silicone hydrogel contact lens.But injection molding contact lenses self produce with the form that is suitable for directly being positioned on the human eye, and processing changes glasses and glasses is applicable on the eyes and need not further.The silicone hydrogel contact lens of the present invention that uses the injection molding program of all programs as shown in Figure 1 and produce is considered to " injection molding silicone hydrogel contact lens " at this paper.If make the glasses product after mold component takes off mirror, not use processing to change eyeglass design, so glasses of the present invention be interpreted as " molded silicone hydrogel contact lens fully ".

The illustrative method that is used for producing contact lenses (such as silicone hydrogel contact lens) is described in following at least patent: United States Patent (USP) the 4th, 121, No. 896, the 4th, 495, No. 313, the 4th, 565, No. 348, the 4th, 640, No. 489, the 4th, 889, No. 664, the 4th, 985, No. 186, the 5th, 039, No. 459, the 5th, 080, No. 839, the 5th, 094, No. 609, the 5th, 260, No. 000, the 5th, 607, No. 518, the 5th, 760, No. 100, the 5th, 850, No. 107, the 5th, 935, No. 492, the 6th, 099, No. 852, the 6th, 367, No. 929, the 6th, 822, No. 016, the 6th, 867, No. 245, the 6th, 869, No. 549, No. the 20030125498th, the 6th, 939, No. 487 and U.S. Patent Publication case, No. 20050154080 and No. 20050191335.

Get back to Fig. 1, the existing simple method of summarizing in the calcspar of describing.Illustrated method comprises step 102, that is: with polymerizable silicone-hydrogel glasses precursor composition (202, be positioned on the contact lens molds member as shown in Figure 2) or inner.Polymerizable silicone-hydrogel glasses precursor composition is meant prepolymerization or the precuring composition that is suitable for polymerization.Polymerisable compound of the present invention as used herein also can be described as " monomer mixture " or " reaction mixture ".Before composition curing or polymerization, polymerisable compound or glasses precursor composition are preferable without being polymerized to any significance degree.Yet in some cases, polymerisable compound or glasses precursor composition can be partially polymerized before standing curing.

Before curing or polymerization procedure, glasses precursor composition of the present invention can be provided in container, distributor or the contact lens molds.

Get back to Fig. 1 step 102, the glasses that the glasses precursor composition are positioned over spill contact lens molds member form on the surface.Spill contact lens molds member generally is meant the first contact lens molds member or anterior contact lens molds member.For instance, spill contact lens molds member has glasses and forms the surface, and described delimited is by the front surface of the contact lenses that contact lens molds produced.

The first contact lens molds member contacts with the second contact lens molds member places the contact lens molds that has contact lenses shape cavity with formation.Therefore, method illustrated in fig. 1 comprises step 104, that is: place by two contact lens molds members are contacted with each other to form contact lenses shape cavity and seal contact lens molds.Polymerizable silicone-hydrogel glasses precursor composition 202 is arranged in contact lenses shape cavity.The second contact lens molds member is meant convex contact lens molds member or rear portion contact lens molds member.For instance, the second contact lens molds member comprises that glasses form the surface, the rear surface of the contact lenses that produced in the described delimited contact lens molds.

" non-polar resin contact lens molds " or " hydrophobic resin contact lens molds " is meant the contact lens molds that is formed or produced by nonpolar or hydrophobic resin as used herein.Therefore, non-polar resin base contact lens molds can comprise nonpolar or hydrophobic resin.For instance, described contact lens molds can comprise one or more polyolefin, or can be formed by the polyolefin resin material.The example of non-polar resin contact lens molds that is used for the situation of the application's case comprises tygon contact lens molds, polypropylene contact lens molds and polystyrene contact lens molds.Non-polar resin base contact lens molds has hydrophobic surface usually.For instance, measure as using captive bubble method, non-polar resin mould or hydrophobic resin mould can have about 90 ° or bigger static contact angle.Under described contact angle, the conventional silicone hydrogel contact lens that is produced in the described mould has unacceptable clinically surperficial wettable.

Described method further comprises solidifies 106 polymerisable silicone-hydrogel glasses precursor compositions to form the preceding polymerization silicone hydrogel contact lens product 204 (as shown in Figure 2) of extraction.During curing, the spectacle of polymerizable silicone-hydrogel glasses precursor composition becomes the component polymerization to form polymerization glasses product.Therefore, curing also can be regarded as polymerization procedure.Solidify 106 and can comprise polymerizable glasses precursor composition is exposed to radiation, such as the mode of the component of heat radiation or any other effective polymerization glasses precursor composition.For instance, solidify 106 and can comprise heat or ultraviolet (UV) light that polymerizable glasses precursor composition is exposed to polymerization amount.Curing can be carried out in oxygen-free environment according to circumstances.For instance, curing can (for example under nitrogen, argon gas or other inert gas) be carried out under inert atmosphere.In a specific embodiment, curing comprises and will be heated to greater than about 55 ℃ temperature as the polymerisable compound that this paper provided.

Polymerization silicone hydrogel contact lens product 204 before the extraction is meant the polymerizate before standing to remove from polymerizate in fact all extraction procedures that can remove/can extract component.With before extracts composition contacts, the polymerization silicone hydrogel contact lens product before the extraction can be provided in that contact lens molds, extracting disk or other device are gone up or be inner.For instance, after program curing, the polymerization silicone hydrogel contact lens product before the extraction can be provided in the glasses shape cavity of contact lens molds; After the contact lens molds demoulding, can be provided on a kind of contact lens molds member or inside; Or after taking off the mirror program and before extraction procedures, can be provided in that extracting disk or other device is gone up or inner.Polymerization silicone hydrogel contact lens product before the extraction comprises that spectacle becomes component (such as the siliceous converging network or the matrix that are the glasses shape) and the component removed that can become the component removal from spectacle.Can remove component comprises the monomer of unreacted monomer, oligomer, partial reaction or becomes other covalently bound or unfixing reagent of component with respect to spectacle.Can remove component and also can comprise one or more adjuvants, include organic additive, comprise thinning agent, it can extract from polymerization glasses product during extraction procedures as previously discussed.Therefore, can comprise linear uncrosslinked, the crosslinked and/or branched polymers that the material that can remove component comprises extractable matter uncrosslinked or fixing with respect to main polymer chain, network or the matrix of mirror body.

In addition, can remove component and can comprise other material, such as volatile matter, it can the passive or removal on one's own initiative of the polymerization silicone hydrogel contact lens product before extract before extraction.For instance, a part can be removed component and can evaporate between demoulding step and extraction step.

After solidifying polymerizable glasses precursor composition, carry out the demoulding 108 of contact lens molds.The demoulding is meant the method for two mold components (such as convex and female mold member) that separate the mould contain the polymerization contact lens product before the extraction or polyplant.Polymerization silicone hydrogel contact lens product before the extraction be positioned at through the mold component of the demoulding one on.For instance, polymerization silicone hydrogel contact lens product can be positioned on convex mold member or the female mold member.

Polymerization silicone hydrogel contact lens product 204 before then will extracting during taking off mirror step 110 (as shown in Figure 1) separates with the contact lens molds member that it is located.Polymerization contact lens product before the extraction can be taken off mirror with convex mold member or female mold member, and this depends on which mold component is the polymerization contact lens product keep adhering to during the contact lens molds demoulding.

Silicone hydrogel contact lens product before extraction takes off after the mirror, and described method comprises that the silicone hydrogel contact lens product before extract extracts 112 extractable matters.Through extraction step 112 can obtain through the extraction silicone hydrogel contact lens product 206 (as shown in Figure 2).Extraction step 112 is the programs of instigating the preceding polymerization silicone hydrogel contact lens product of extraction to contact with one or more extracts compositions, and can comprise single extraction step or several times continuous extraction.For instance, polymerization silicone hydrogel contact lens product or a collection of polymerization silicone hydrogel contact lens product contact with one or the liquid extraction medium of many volumes.Spe medium generally includes one or more solvents.For instance, spe medium comprises ethanol, methyl alcohol, propyl alcohol and other alcohols.Spe medium also can comprise the potpourri of alcohols and water, such as the potpourri of 50% ethanol and 50% deionized water, or the potpourri of 70% ethanol and 30% deionized water, or the potpourri of 90% ethanol and 10% deionized water.Perhaps, spe medium can be in fact or is not had alcohol fully, and can comprise that one or more help removing from polymerization silicone-hydrogel glasses product the reagent of hydrophobicity unreacted component.For instance, spe medium can comprise water, buffer solution and like that, form or form by it fully by it basically.Extraction 112 can be carried out under all temps (comprising room temperature).For instance, extraction can take place down in room temperature (for example about 20 ℃), or it can take place down at high temperature (for example about 25 ℃ to about 100 ℃).In addition, in certain embodiments, extraction step 112 can comprise makes the glasses product contact with the potpourri of water with alcohol, and in some cases, it can comprise the final step of multistep extraction procedures.

Polymerization silicone hydrogel contact lens product before extracting is being implemented extraction to provide after the polymerization silicone hydrogel contact lens product of extraction, described method comprises the polymerization silicone hydrogel contact lens product of hydration 114 through extraction.Hydration step 114 for example can comprise makes that a collection of or many batches of described products contact with water or aqueous solution with formation hydration silicone hydrogel contact lens 208 (as shown in Figure 2) through the polymerization silicone hydrogel contact lens product of extraction.For example, the polymerization silicone hydrogel contact lens product through extraction can come hydration by being positioned in two independent volumes or the two independent water (comprising deionized water) more than the volume.In certain embodiments, hydration step 114 and extraction step 112 combinations are so that two steps can be carried out at the single station in contact lens production line.Hydration step 114 can under high pressure be carried out under room temperature or high temperature and in case of necessity in container.For instance, hydration can take place in water under the pressure of the temperature of about 120 ℃ (for example 121 ℃) and 103kPa (15psi).

Therefore, as by above apparent, think that polymerization silicone hydrogel contact lens product and the polymerization silicone hydrogel contact lens product through extracting before the extraction are the product or the element of water expansiveness, and think that the hydration silicone hydrogel contact lens is through water swellable product or element.Silicone hydrogel contact lens is meant the silicone-hydrogel element that experiences hydration step as used herein.Therefore, silicone hydrogel contact lens can be the silicone hydrogel contact lens of complete hydration, partially hydrated silicone hydrogel contact lens or the silicone hydrogel contact lens of dehydration.The silicone hydrogel contact lens of dehydration be meant experience hydration procedures and with after dehydration to remove the contact lenses of water from glasses.

With after producing silicone hydrogel contact lens, described method comprises the step 116 of packing silicone hydrogel contact lens 208 at the silicone hydrogel contact lens product of hydration through extracting.For instance, silicone hydrogel contact lens 208 can be positioned in the blister package or other suitable vessel that comprises certain volume liquid (such as normal saline solution, comprising buffer saline solution).The example that is suitable for the liquid of glasses of the present invention comprises phosphate buffered saline and borate buffer saline.Shown in step 118, then sealed blister is packed or container, and sterilization subsequently.For instance, the silicone hydrogel contact lens through packing can comprise heat radiation such as the radiation that is exposed to bactericidal amount by autoclave processing, γ radiation, electron beam irradiation or UV radiation.

The characteristic of silicone-hydrogel glasses

As above discuss, composition that this paper provided and method provide eyes compatible silicone hydrogel contact lens.Extraction of polymerization silicone-hydrogel glasses product before the extraction and hydration had eye with accepting surperficial wettable silicone hydrogel contact lens with formation.Glasses of the present invention have oxygen permeability, surperficial wettable, modulus, liquid water content, ion flow, design and its combination, it makes glasses of the present invention be fit to the period that patient's eye is cosily worn prolongation, such as at least one sky, at least one week, at least two weeks or about one month, and need not from eyes, to remove glasses.

" silicone hydrogel contact lens that eyes are compatible " is meant and can wears on human eye and the people can not experience or report the silicone hydrogel contact lens of substantive uncomfortable (comprising eye irritation etc.) as used herein.The compatible silicone hydrogel contact lens of eyes has eye with can accepting surperficial wettable, and can not cause remarkable cornea swelling usually, corneal dehydration (" scheroma "), the arciform pathology of top corneal epithelium (" SEAL ") or other significant discomfort or uncorrelated with described symptom.Have eye and be meant that with accepting surperficial wettable silicone hydrogel contact lens the tear film that can sharp influence the lens wearer eyes is to causing placement on lens wearer experience or report and the eyes or wearing the silicone hydrogel contact lens of the degree of the relevant discomfort of silicone hydrogel contact lens.The compatible silicone hydrogel contact lens of eyes satisfies at the acceptable clinically requirement of wearing or wearing for a long time contact lenses every day.

Silicone hydrogel contact lens of the present invention comprises the mirror body, and it has the tool eye with the surface that can accept surperficial wettable (OASW), such as front surface and rear surface.Wettable is meant the water wettability on one or more surfaces of contact lenses.In a kind of measuring method, if glasses obtain the scoring more than 3 or 3 in the following wettable analysis of carrying out, can think that so lens surface is wettable, can think that maybe it has the acceptable wettable of eye.Contact lenses are immersed in the distilled water, from water, shift out, and the mensuration moisture film retreats the time span (for example water drive is loose the time (water BUT or WBUT)) that is consumed from lens surface.Analysis provides the glasses grade on the linear scale of 1-10, wherein is meant the glasses that wherein water droplet needed 20 seconds or the longer time retreats from glasses in 10 minutes.Though the in vitro assessment of WBUT only be a kind of measuring method or indication for OASW, can think and have more than 5 seconds that the silicone hydrogel contact lens of (such as at least 10 seconds or betterly be at least about 15 seconds) water BUT has with accepting surperficial wettable.Perhaps, can assess OASW in vivo.The patient does not report discomfort or stimulation if glasses can be worn on patient's eye 6 hours at least, thinks that so glasses have OASW.

Wettable also can be measured by measuring one or two contact angle on the lens surface.Contact angle can be dynamically or static contact angle.Low contact angle is meant that generally the wettable of contact lens surface increases.For instance, the wettable surface as the silicone hydrogel contact lens that this paper provided can have less than about 90 ° contact angle.Yet in some embodiment of glasses of the present invention, glasses have and are not more than 80 ° contact angle, and in other embodiments, and silicone hydrogel contact lens of the present invention has less than about 75 ° and even better for about 70 ° advancing contact angle.In one embodiment, glasses have at about 52 ° of advancing contact angles to about 62 ° of scopes.

Silicone hydrogel contact lens of the present invention comprise have the eye with accepting surperficial wettable mirror body.For instance, the mirror body of silicone hydrogel contact lens of the present invention has front surface and rear surface usually, and each surface all has eye with acceptable surperficial wettable.

In one embodiment, the mirror body of silicone hydrogel contact lens comprises the silicone-hydrogel material.The mirror soma weighed 90% dry weight before the mirror body had the extraction of being not more than.For instance, the mirror body of the polymerization silicone hydrogel contact lens product before the extraction can have dry weight X.After the extraction procedures, the mirror body of the polymerization silicone hydrogel contact lens product through extracting has the dry weight that is less than or equal to 0.9X.As above discuss, during extraction step, the polymerization silicone hydrogel contact lens product before the extraction can contact with a large amount of multiple organic solvents, carries out hydration step then to produce silicone hydrogel contact lens.Then, with hydration silicone hydrogel contact lens dehydration and weigh heavy with the mirror soma of measuring silicone hydrogel contact lens.

For instance, in some method, the polymerization silicone hydrogel contact lens product before the extraction is taken off mirror from the contact lens molds member, and weigh so that the dry weight of the preceding polymerization silicone hydrogel contact lens product of extraction to be provided.Then make the preceding glasses product of extraction contact about 6 hours, and then carry out hydration with water with alcohol.Then at about 80 ℃ of about 1 hour of dry hydration glasses down, and then under vacuum in about 80 ℃ dry about 2 hours down.The glasses of the drying of weighing are heavy with the mirror soma of measuring silicone hydrogel contact lens.Then more described dry weight is to determine the amount of existing extractable matter in the preceding polymerization silicone hydrogel contact lens product of extraction.Have the about 40% extraction pre-polymerization glasses product that can extract component content and produce the mirror body of dry weight for the silicone hydrogel contact lens of the preceding glasses product about 60% of extraction.Have the about 70% extraction pre-polymerization glasses product that can extract component content and produce the mirror body of dry weight for the silicone hydrogel contact lens of the preceding glasses product about 30% of extraction, or the like.

The amount of existing extractable matter maybe can extract component content and can use following equation to determine in the polymerization silicone hydrogel contact lens product before the extraction:

E=((dry weight of glasses product before the extraction-through the dry weight of the extraction and the contact lenses of hydration)/dry weight of glasses product before extracting) * 100.

E is the number percent of existing extractable matter in the preceding glasses product of extraction.

For instance, the polymerization silicone hydrogel contact lens product before the extraction can have the dry weight of about 20mg.If have the dry weight of about 17mg from the silicone hydrogel contact lens that product obtained, that silicone hydrogel contact lens comprises the mirror body of dry weight for the preceding glasses product dry weight 85% of extraction so.Should be appreciated that the extracted component content that the glasses product has about 15% (weight ratio) before the described extraction.As another example, polymerization silicone hydrogel contact lens product before the extraction can have the dry weight of about 18mg, if and had the dry weight of about 13mg from the silicone hydrogel contact lens that described glasses product is obtained through dehydration, so described silicone hydrogel contact lens would comprise the mirror body of dry weight for the preceding glasses product about 72% of extraction.The extracted component content that polymerization silicone hydrogel contact lens product before the described extraction has about 28% (weight ratio).

In certain embodiments, the mirror soma of silicone hydrogel contact lens (that is to say the silicone hydrogel contact lens that is extracted with hydration procedures) is great in 70% of the dry weight of mirror body before extraction.For instance, the mirror soma after the extraction heavily can be the extraction before the mirror soma heavy about 70% to about 90%.Some embodiment of glasses of the present invention comprise dry weight for extraction before about 70% to about 78% heavy mirror body of mirror soma.In at least one embodiment, silicone hydrogel contact lens have the extraction before mirror soma heavily about 74% dry weight.

Though extraction pre-polymerization silicone hydrogel contact lens product of the present invention contains extractable matter, silicone hydrogel contact lens of the present invention in gained mirror body, have the extractable matter of indivisible (if not significant quantity) through the extraction form.In certain embodiments, the amount of remaining extractable matter is about 0.1% to about 4% in the glasses of extraction, and is all according to appointment 0.4% to about 2% (weight ratio).Described extra extractable matter can contact with the strong solvent (such as chloroform) of additional volumes and measures by making the contact lenses through extraction.

In addition, exist and be distributed in the polymerization silicone hydrogel contact lens product before whole polymerisable silicone-hydrogel glasses precursor composition and the extraction owing to can extract component, therefore glasses product of the present invention and contact lenses can be different from surface treated silicone hydrogel contact lens.Can and not be present in fact through the contact lenses of hydration from the extraction of glasses product owing to can extract component, therefore glasses product of the present invention and contact lenses can be different from the silicone hydrogel contact lens with polymerization wetting agent IPN.

Silicone hydrogel contact lens of the present invention can comprise the mirror body that is obtained from the non-polar resin contact lens molds, and described mirror body has identical in fact configuration of surface when checking under hydration and dewatering state.In addition, described hydration mirror body can have slightly the surfaceness less than the surfaceness of dehydration mirror body.For instance, glasses mirror body of the present invention can have the surface that comprises the big small peak of nanometer, and the big small peak of described nanometer is apparent when analyzing root mean square (RMS) coarseness data of lens surface.The mirror body can be included in the described peak-to-peak zone of otherness protuberance between each peak, the similar in fact configuration of surface with the roughness that minimizing is provided.For instance, though peak height can reduce when the hydration of mirror body, it is identical that peak shape keeps in fact.

Perhaps or in addition, the embodiment through the molded silicone hydrogel contact lens of non-polar resin of the present invention can comprise have with electron microscope (such as scanning electron microscope, transmission electron microscope or scanning transmission electron microscope) but the silicon-rich areas of visual discrimination and the mirror body of poor silicon area when observing.Based on chemical analysis, can understand poor silicon area for there not being the glasses inner region of silicon in fact or fully.Poor silicon area may be bigger than surface treated silicone hydrogel contact lens or the described district that comprises in the silicone hydrogel contact lens of polymerization wetting agent IPN.Can use conventional image analysing computer software and device (such as can be) to measure silicon-rich areas, poor silicon area or both sizes available from the image analysis system of quantitative biological study center (Bioquant) (tennessee,USA (Tennessee)).The image analysing computer software systems can be in order to the boundary profile of sketching the contours of silicon-rich areas and poor silicon area and the cross-sectional area of measuring described district, diameter, volume etc.In certain embodiments, poor silicon area has the cross-sectional area than the poor silicon area big at least 50%, at least 60%, at least 70%, at least 80% or at least 90% of other silicone hydrogel contact lens.

Not surface treated mirror body of the present invention provides eye with accepting surperficial wettable usually.In other words, in one embodiment, the mirror body of silicone hydrogel contact lens of the present invention is not surface treated mirror body.In other words, under the surface-treated situation of not carrying out the mirror body, produce the mirror body to provide eye with accepting surperficial wettable.For instance, illustrative mirror body does not comprise that usefulness is so that mirror surface more acceptable plasma treatment or additional coatings on eyes.Although glasses of the present invention have eye with accepting surperficial wettable, some embodiment still can comprise surface treatment in case of necessity.

Some embodiment of glasses of the present invention comprises the injection molding element mirror body that obtains from the non-polar resin contact lens molds.Polymerization silicone hydrogel contact lens product is meant the product of in non-polar resin contact lens molds polymerization or curing.Perhaps, explanation in another way, polymerization silicone hydrogel contact lens product produces in the non-polar resin contact lens molds.As discussed herein, described contact lens molds is for using nonpolar or hydrophobic resin material or based on mould nonpolar or that the hydrophobic resin material produces.Described material forms at its glasses usually has big relatively contact angle on the surface.

Glasses of the present invention can comprise on front surface, rear surface or preceding and the rear surface advancing contact angle less than 90 ° through hydration mirror body.The mirror body has usually less than 75 ° mirror surface advancing contact angle, and for example the mirror body has approximately mirror surface advancing contact angle in next person (with °): 74,73,72,71,70,69,68,67,66,65,64,63,62,61,60,59,58,57,56,55,54,53,52,51 or 50.The mirror body also can have less than about 75 ° mirror surface receding contact angle.For example, the mirror body can have approximately mirror surface receding contact angle in next person (with °): 74,73,72,71,70,69,68,67,66,65,64,63,62,61,60,59,58,57,56,55,54,53,52,51,50,49,48,47,46,45,44,43,42,41 or 40.In one or more embodiments, the mirror body have about 40 ° to about 60 ° receding contact angle.

Hysteresis as the difference between advancing contact angle and the receding contact angle is generally about 5 ° to about 25 °.Yet, in preferred embodiment, lag behind about 5 ° to about 15 ° scope, although in some cases, glasses can have greater than about 25 ° hysteresis, but still for acceptable clinically.

Can use the known conventional method of one of ordinary skill in the art to measure advancing contact angle.For instance, can use conventional droplet profile method (such as stopping dripping method or captive bubble method) to measure the advancing contact angle and the receding contact angle of contact lenses.The water contact angle that moves forward and backward of silicone hydrogel contact lens can use Ke Lvshi (Kruss) DSA100 utensil ((the Kruss GmbH of Hamburg, Germany Ke Lvshi company, Hamburg)) and as D.A. Blanc De Ruisi (Brandreth): " dynamic contact angle and contact angle hysteresis (Dynamic contact angles and contact angle hysteresis) ", colloid and interface science magazine (Journal of Colloid and Interface Science), the 62nd volume, 1977,205-212 page or leaf and R. receive general kvass base (R.Knapikowski), M. storehouse moral (M.Kudra): Kontaktwinkelmessungen nach demWilhelmy-Prinzip-Ein statistischer Ansatz zur Fehierbeurteilung ＂, chemical technology (Chem.Technik), the 45th volume, 1993,179-185 page or leaf and United States Patent (USP) the 6th, measure described in 436, No. 481.

For example, advancing contact angle and receding contact angle can use captive bubble method to use phosphate buffered saline (PBS; PH=7.2) measure.Glasses are tiled on the quartz surfaces and before test with rehydrated 10 minutes of PBS.Use automatic injecting systems that bubble is positioned on the lens surface.Can increase and reduce the bubble size to obtain receding angle (when increasing the bubble size, obtaining platform) and advancing angle (when reducing the bubble size, obtaining platform).

Perhaps or in addition, glasses of the present invention can comprise displaying greater than the loose mirror body of time (BUT) of 5 seconds water drive.For instance, comprise water BUT and can have eye with accepting surperficial wettable for the embodiment of glasses of the present invention of the mirror body of at least 15 seconds (such as 20 seconds or longer time).

Glasses of the present invention generally comprise the mirror body of modulus less than 1.6MPa.The feature of glasses is its modulus usually between about 0.5 to about 1.5mPa, and is preferable between about 0.6 to about 1.2mPa.In one or more embodiments, glasses have the modulus between about 0.8 to about 1.0MPa.For instance, the mirror body can have the modulus of about 1.2MPa, 1.1MPa, 1.0MPa, 0.9MPa, 0.8MPa, about 0.7MPa, about 0.6MPa or about 0.5MPa.Select mirror phantom amount comfortable glasses to be provided and to make lens wearer can adapt to the operation of glasses with on being positioned over eyes the time.

Can use the known conventional method of one of ordinary skill in the art to measure the modulus of mirror body.For instance, downcut the contact lens of the about 4mm of width from the glasses core, and stretch modulus (unit: MPa) can be by measuring in the initial slope of in the air of at least 75% humidity, carrying out the stress-strain diagram that extension test was obtained with the speed of 10mm/min under 25 ℃ by use Instron (Instron) 3342 (Instron company (Instron Corporation)).

The ion flow of glasses mirror body of the present invention is usually less than about 5 * 10 ^-3Mm ²/ min.Though some glasses mirror body of the present invention can have up to about 7 * 10 ^-3Mm ²The ion flow of/min, but believe and work as ion flow less than about 5 * 10 ^-3Mm ²/ min, and when contact lenses do not comprise MPC, can reduce corneal dehydration dyeing.In certain embodiments, the ion flow of mirror body is about 2 * 10 ^-3Mm ²/ min is to about 5 * 10 ^-3Mm ²In the scope of/min.For instance, ion flow can be about 2 * 10 ^-3Mm ²/ min, 2.5 * 10 ^-3Mm ²/ min, 3.0 * 10 ^-3Mm ²/ min, 3.5 * 10 ^-3Mm ²/ min, 4.0 * 10 ^-3Mm ²/ min, 4.5 * 10 ^-3Mm ²/ min or about 5 * 10 ^-3Mm ²/ min.Yet as described herein, ion flow can be greater than 7 * 10 ^-3Mm ²/ min, but do not cause corneal dehydration dyeing or other clinical problem yet.

The ion flow of glasses mirror body of the present invention can use the known conventional method of one of ordinary skill in the art to measure.For instance, the ion flow of contact lenses or mirror body can use and be similar to United States Patent (USP) the 5th, 849 in fact, and the technology of " ion flow technology (the Ionoflux Technique) " described in No. 811 is measured.For instance, glasses to be measured can be placed between the convex and concave portions in the eyewear retention system.Convex and concave portions comprise the flexible sealing ring between glasses and each convex or concave portions.After being positioned glasses in the eyewear retention system, eyewear retention system is positioned in the threaded lid.Lid is screwed onto on the glass tube to define the feed chamber.Can be filled with the NaCl solution of 16ml0.1 volumetric molar concentration in the feed chamber.Receive chamber and can be filled with the 80ml deionized water.The lead of diagometer is immersed in the deionized water that receives chamber, and stirring rod is added in the reception chamber.To receive chamber and be placed in the constant temperature oven, and temperature will be maintained at about 35 ℃.At last, the feed chamber is immersed in the reception chamber.Can beginning in 10 minutes after the feed chamber immerse is received chamber, carried out the measurement of conductivity every two minutes, last about 20 minutes.It is linear that conductivity and time relation data should be in fact.

Glasses mirror body of the present invention has high oxygen permeability usually.For instance, the mirror body has the oxygen permeability that Dk is not less than 60 Barres.It is about 80 Barres, about 90 Barres, about 100 Barres, about 110 Barres, about 120 Barres, about 130 Barres, about 140 Barres or bigger mirror body that the embodiment of glasses of the present invention comprises Dk.Glasses are preferable to have about 70 Dk to about 110 Barres and better about 80 to 100 Barres.

Can use the known conventional method of one of ordinary skill in the art to measure the Dk of glasses of the present invention.For instance, the Dk value can be used as United States Patent (USP) the 5th, 817, and film health (Mocon) method described in No. 924 is measured.The Dk value can use model name to measure as the commercially available utensil of film health oxygen flow system (Mocon Ox-Tran System).

Glasses of the present invention also comprise and have eye with the mirror body of acceptable liquid water content.For instance, the embodiment of glasses of the present invention comprises equilibrium water content and is not less than about 30% mirror body.In certain embodiments, the mirror body has the equilibrium water content to about 60 weight % scopes at about 40 weight %.For instance, the glasses that this paper provided can have about 35%, about 40%, about 45%, about 50%, about 55%, about 60% or even about 65% equilibrium water content.In one or more embodiments, the mirror body has the equilibrium water content of about 42 weight % to about 50 weight %.

Can use the known conventional method of one of ordinary skill in the art to measure the liquid water content of glasses of the present invention.For instance can with, the hydration silicone hydrogel contact lens shifts out from waterborne liquid, wiping to be removing excessive surface water, and weighs.Then can the glasses through weighing are dry in 80 ℃ of vacuum in baking oven, and the glasses of the drying of then can weighing.Come gravimetry poor by deducting dry glasses weight by hydration glasses weight.Liquid water content (%) is (weight difference/hydration weight) * 100.

Except that the determined particular value above, glasses of the present invention can have the value in the scope between any combination of determined particular value above.

For instance, contact lenses of the present invention can have about 42% to about 50% liquid water content, and about 3 to about 5 (* 10 ^-3Mm ²/ min) ion flow valuve, about 52 ° to about 62 ° advancing contact angle, about 40 ° to about 60 ° receding contact angle, about 5 ° to about 15 ° hysteresis, about 0.6MPa is Young modulus (Young ' s moduli), the length growth rate at least about 100% and its combination of about 1.2MPa extremely.In certain embodiments, length growth rate is about 100% to about 300%.

As discussed herein, glasses of the present invention have feature and the characteristic that allows glasses to wear prolonging period.For instance, glasses of the present invention can be used as wear glasses every day, wear glasses weekly, two week wears glasses or wore glasses in every month and wear.Glasses of the present invention comprise the hydration mirror body with surperficial wettable, modulus, ion flow, oxygen permeability and liquid water content of helping glasses comfort level and availability.

Silicone hydrogel contact lens of the present invention is to correct defects of vision or strengthen the contact lenses of eyesight.Glasses can be sphere glasses or aspheric surface glasses.Glasses can be single focus glasses or multifocal spectacles, comprise bifocal slasses.In certain embodiments, glasses of the present invention are the spin stabilization glasses, such as the spin stabilization toric contact lens.The spin stabilization contact lenses can be the contact lenses that comprise the mirror body that comprises ballast.For instance, the mirror body can have prism ballast thing, ballast and/or zone, one or more thinnings above and below on every side.

Glasses of the present invention also comprise the mirror body that comprises peripheral edge regions.Peripheral edge regions can comprise circular portion.For instance, peripheral edge regions can comprise rounded back edge surface, rounded forward edge edge surface or its combination.In certain embodiments, the neighboring is circular fully from the front surface to the rear surface.Therefore, the mirror body that can understand glasses of the present invention can comprise the circular circumference edge.

Glasses of the present invention can comprise that its thickness distribution can solve the problem relevant with existing silicone hydrogel contact lens but concerning lens wearer still comfortable mirror body.By changing mirror body thickness and mirror phantom amount, the hardness of may command mirror body.For instance, the hardness in a contact lenses zone may be defined as the product of the glasses thickness square of the Young modulus of glasses and appointed area.Therefore, some embodiment of glasses of the present invention can comprise core rigidities (for example hardness at glasses center or vision area center) less than about 0.007MPa-mm ², glasses connect surface hardness less than about 0.03MPa-mm ²Or the mirror body of its combination.Glasses connect that face (lenticular junction) may be defined as glasses district (lenticular zone) and inclined-plane or for the glasses of slope-less apart from the face that connects (referring to United States Patent (USP) the 6th, 849, No. 671) of the point of the about 1.2mm in glasses edge.In other embodiments, glasses of the present invention can comprise core rigidities greater than 0.007MPa-mm ², glasses connect surface hardness greater than about 0.03MPa-mm ²Or the mirror body of its combination.

During silicone hydrogel contact lens of the present invention can be provided in to pack.For instance, silicone hydrogel contact lens of the present invention can be provided in the sealed blister packing or be suitable for paying in other similar containers of lens wearer.Glasses can be stored in the interior aqueous solution of packing, such as normal saline solution.Some appropriate solution comprises phosphate buffered saline solution and borate buffer solution.Optionally, solution can comprise that germifuge maybe can not have germifuge or antiseptic.Optionally, solution also can comprise surfactant, such as poloxamer (poloxamer) etc.

Glasses in packing are preferable aseptic.For instance, glasses can be before packing sterilization or can pack interior sterilization.Can be the glasses of the radiation that is exposed to bactericidal amount through the glasses of sterilization.For instance, glasses can be through autoclave treated glasses, the glasses that expose through gamma-emitting glasses, through UV radiation etc.

Example

Following example explanation some aspect of the present invention and advantage, however think that never the present invention is limited to the specific embodiment of the following stated.

Unless otherwise noted, otherwise practice of the present invention will adopt that polymkeric substance in this technical skills scope is synthetic, the routine techniques of hydrogel formation etc.Described technology proves absolutely in the literature.Unless opposite certain illustrated, otherwise reagent and material are commercially available.

The method for preparing contact lenses (for example silicone hydrogel contact lens) is further described in the following patent: United States Patent (USP) the 4th, 121, No. 896, the 4th, 495, No. 313, the 4th, 565, No. 348, the 4th, 640, No. 489, the 4th, 889, No. 664, the 4th, 985, No. 186, the 5th, 039, No. 459, the 5th, 080, No. 839, the 5th, 094, No. 609, the 5th, 260, No. 000, the 5th, 607, No. 518, the 5th, 760, No. 100, the 5th, 850, No. 107, the 5th, 935, No. 492, the 6th, 099, No. 852, the 6th, 367, No. 929, the 6th, 822, No. 016, the 6th, 867, No. 245, the 6th, 869, No. 549, No. the 20030125498th, the 6th, 939, No. 487 and U.S. Patent Publication case, No. 20050154080 and No. 20050191335.

In following example, though endeavoured to ensure and the relevant accuracy of used numeral (for example amount, temperature etc.), but still should consider some experimental error and deviation.Unless otherwise noted, otherwise temperature in ℃, and pressure is atmospheric pressure or near atmospheric pressure under the sea level.

The chemical substance of below knowing is mentioned in example, and in some cases, is mentioned by the abbreviation of its following proposition.

Material and method

Abbreviation

AE: allyloxyethanol

DI: deionization

MMA: methyl methacrylate

M3U:M3-U; α-ω-two (methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyl)-poly-(dimethyl siloxane)-poly-(trifluoro propyl methylsiloxane)-poly-(ω-methoxyl-poly-(ethylene glycol) propyl group methylsiloxane; The macromonomer that contains dimethyl propylene enoyl-silica

M3U used in the following example is expressed from the next, and wherein n is 121, and m is 7.6, and h is 4.4, and p is 7.4, and Mn=12, and 800, and Mw=16,200 (company limited of Japanese Asahi Chemical Industry (Asahikasei Aime Co., Ltd., Japan)).

M3U colorant: the dispersion liquid (weight %) of β copper phthalocyanine in M3U.Copper phthalocyanine can obtain with phthalocyanine blue (Heliogen Blue) K7090 from BASF (BASF).

N, N-DMF:DMF; N, dinethylformamide

NVP:1-vinyl-2-Pyrrolidone (fresh distillation under vacuum)

PDMS: dimethyl silicone polymer

PDMS-is total to-PEG: the segmented copolymer of dimethyl silicone polymer and PEG, it contains 75%PEG and MW is 600 (from the DBE712 of Jie Lesite company (Gelest))

PEG: polyglycol

PP: propyl group propylene

EGDMA: Ethylene glycol dimethacrylate

TEGDVE: triethylene glycol divinyl ether

TPTMA: trimethylol-propane trimethacrylate

UV416: acrylic acid 2-(4-benzoyl-3-hydroxyphenoxy) ethyl ester

Vazo-64: azoisobutyronitrile (V-64; Thermal initiator)

VMA:N-vinyl-N-methylacetamide (fresh distillation under vacuum)

VM: metering system vinyl acetate

Characterize the method for glasses product

Advancing contact angle/receding contact angleCan use the known conventional method of one of ordinary skill in the art to measure advancing contact angle.For instance, can use conventional droplet profile method (such as stopping dripping a method or a captive bubble method) to measure the advancing contact angle and the receding contact angle of the contact lenses that this paper provides.The water contact angle that moves forward and backward of silicone hydrogel contact lens can use Ke Lvshi (Kruss) DSA100 utensil ((the Kruss GmbH of Hamburg, Germany Ke Lvshi company, Hamburg)) and as D.A. Blanc De Ruisi (Brandreth): " dynamic contact angle and contact angle hysteresis (Dynamic contact angles andcontact angle hysteresis) ", colloid and interface science magazine (Journal of Colloid and InterfaceScience), the 62nd volume, 1977,205-212 page or leaf and R. receive general kvass base (R.Knapikowski), M. storehouse moral (M.Kudra): Kontaktwinkelmessungen nach dem Wilhelmy-Prinzip-Ein statistischer Ansatzzur Fehierbeurteilung ＂, chemical technology (Chem.Technik), the 45th volume, 1993,179-185 page or leaf and United States Patent (USP) the 6th, measure described in 436, No. 481.

ModulusCan use the known conventional method of one of ordinary skill in the art to measure the modulus of mirror body.For instance, can downcut the contact lens of the about 4mm of width from the glasses core, and stretch modulus (unit: MPa) can be by measuring in the initial slope of in the air of at least 75% humidity, carrying out the stress-strain diagram that extension test was obtained with the speed of 10mm/min under 25 ℃ by use Instron (Instron) 3342 (Instron companies).

Ion flowThe ion flow of glasses mirror body of the present invention can use the known conventional method of one of ordinary skill in the art to measure.For instance, the ion flow of contact lenses or mirror body can use and be similar to United States Patent (USP) the 5th, 849 in fact, and the technology of " ion flow technology (the Ionoflux Technique) " described in No. 811 is measured.For instance, glasses to be measured can be placed between the convex and concave portions in the eyewear retention system.Convex and concave portions comprise the flexible sealing ring between glasses and each convex or concave portions.After being positioned glasses in the eyewear retention system, eyewear retention system is positioned in the threaded lid.Lid is screwed onto on the glass tube to define the feed chamber.Can be filled with the NaCl solution of 16ml 0.1 volumetric molar concentration in the feed chamber.Receive chamber and can be filled with the 80ml deionized water.The lead of diagometer is immersed in the deionized water that receives chamber, and stirring rod is added in the reception chamber.To receive chamber and be placed in the constant temperature oven, and temperature will be maintained at about 35 ℃.At last, the feed chamber is immersed in the reception chamber.Can beginning in 10 minutes after the feed chamber immerse is received chamber, carried out the measurement of conductivity every two minutes, last about 20 minutes.It is linear that conductivity and time relation data should be in fact.

Oxygen permeability can use the known conventional method of one of ordinary skill in the art to measure the Dk of glasses of the present invention.For instance, the Dk value can be used as United States Patent (USP) the 5th, 817, and film health (Mocon) method described in No. 924 is measured.The Dk value can use model name to measure as the commercially available utensil of film health oxygen flow system (Mocon Ox-Tran System).

Equilibrium water contentCan use the known conventional method of one of ordinary skill in the art to measure the liquid water content of glasses of the present invention.For instance, the hydration silicone hydrogel contact lens can be shifted out from waterborne liquid, wiping to be removing excessive surface water, and weighs.Then can the glasses through weighing are dry in 80 ℃ of vacuum in baking oven, and the glasses of the drying of then can weighing.Come gravimetry poor by deducting dry glasses weight from hydration glasses weight.Liquid water content (%) is (weight difference/hydration weight) * 100.

Example 1

The preparation of polymerizable silicone hydrogel contact lens precursor composition

Use the reagent and the relative quantity of following appointment to prepare polymerizable silicone hydrogel contact lens precursor composition.This composite is referred to herein as " HM composite ".

Table 1

Compound (abbreviation)

Unit quantity (part)

Weight % (weight ratio)

M3U	35	34.3
			VMA	47	46.1
MMA	17	16.7
			EGDMA	0.5	0.49
AE	1.1	1.1

UV416	0.9	0.88
			Colorant (PB15; Phthalocyanine blue, m3u indigo plant)	0.1	0.10
VAZO-64	0.3	0.29

Amount to 101.9 parts

Weigh in the table 1 component and mix to form potpourri.Via 0.2-20.0 micron injection filter potpourri is filtered in the bottle, and storage reaches about 2 weeks.(this potpourri is referred to herein as polymerizable silicone hydrogel contact lens precursor composition).In table 1, remove separately percentage by weight and (represent with w/w; Each compound of unit quantity is provided weight ratio) in addition.Because the relative umber of each component amounts to up near 100 sum, therefore in the case, the percentage by weight of each component is substantially the same with relative umber.The ratio of MMA and VMA is 0.36:1 in the polymerisable compound.

Example 2

The manufacturing of silicone hydrogel contact lens

Use repeating vacuum/nitrogen wash program that a large amount of precursor compositions from example 1 are outgased.Then will be positioned in the spill non-polar resin mold component through the precursor composition of the degassing.Then by placing the female mold member that seals through filling reaching under the required pressure that closely cooperates contact with non-polar resin convex mold member.Then in nitrogen batch of material baking oven, be cured: 30min N under the room temperature with following circulation ₂Purify 65 ℃ of following 60min and 100 ℃ of following 30min.Carry out the demoulding by the female mold member that knocks contact lens molds, so that the convex mold member is from wherein discharging, wherein polymerization silicone hydrogel contact lens product adheres to the convex mold member.By floating off method or using machinery to take off mirror device and take off mirror.The method of floating off comprises that the convex mold member that will contain dry glasses is soaked in one barrel of water.Glasses left mould usually in about 10 minutes.Adhere to its convex mold member by compression and rotation polymerization silicone hydrogel contact lens product, guiding gas between contact lens product with rotate between the convex mold member, and the exposed surface of contact lens product is applied vacuum carry out machinery and take off mirror.Then separated glasses are carried on the vinyl disc to extract and hydration.

At room temperature, the glasses dish that will contain polymerization silicone hydrogel contact lens product immerses in the solvent liquid (such as the industrial methylated spirit (IMS) that contains 95% ethanol and 5% methyl alcohol) and lasts 45min.Then discharge solvent and replace, and repeat described method with IMS (3 times), 1:1 alcohol/water (1 time) and DI water (3 times) with fresh IMS.

Be stored in the hydration glasses in the vial that contains DI water or the blister package or be stored in the pH value in the phosphate buffered saline of 7.1-7.5.Under 121 ℃, the airtight container autoclave is handled 30min.After autoclave is handled 24h, carry out glasses and measure.The gained hydration silicone hydrogel contact lens of weighing, and then in baking oven, dewater, and weigh once more to measure the dry weight through the silicone hydrogel contact lens of dehydration.

As described herein, measure the glasses characteristic, such as characteristics such as contact angle (comprising dynamic contact angle and static contact angle), oxygen permeability, ion flow, modulus, length growth rate, pulling strengrth, liquid water contents.The wettable of hydration silicone hydrogel contact lens also detects by the water drive of the measuring glasses time of loosing.

During distributing research, further detect the eyes compatibility, wherein contact lenses are positioned over last 1 hour on the human eye, 3 hours or 6 hours or longer time, and then carry out clinical assessment.

Has eye with acceptable surperficial wettable by the silicone hydrogel contact lens that composite of the present invention produced.Described silicone hydrogel contact lens has the equilibrium water concentration (EWC) of 44-47%, and has the extractable of about 26% (weight ratio) after measured.

Gained hydration contact lenses have following characteristic:

Table 2

Characteristic	Value
		Equilibrium water content (EWC)	45-47％
Oxygen permeability (D _k)	91 Barres
		Static contact angle (catching the bubble angle of wetting)	36-38°
Dynamic contact angle (advancing contact angle)	58°
		Dynamic contact angle (receding contact angle)	50°
Lag behind (advancing-retreat)	8°
		Refractive index	1.40
Ion flow	3-4
		Modulus	0.8-1.0MPa
Pulling strengrth	0.6-0.7MPa

Those skilled in the art in the invention will understand, and multiple modification of the present invention and other embodiment have the benefit of the teaching that presents in the aforementioned description.Therefore, should be appreciated that to the invention is not restricted to specific embodiment disclosed herein, thereby present by way of example.Though argumentation exemplary embodiments, the purpose that should understand aforementioned embodiments be to cover embodiment all modifications, substitute and equivalent, define as other disclosure and can belong in spirit of the present invention and the category.Though this paper adopts particular term, it only uses and unrestricted purpose with general and descriptive sense.

Above quoting a large amount of openly case and patents.The mode that open case of being quoted and patent are quoted separately in full is incorporated herein.

Claims

1. polymerisable compound, it comprises α-ω-two (methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyls)-poly-(dimethyl siloxane)-poly-(trifluoro propyl methylsiloxane)-poly-(ω-methoxyl-poly-(ethylene glycol) propyl group methylsiloxane), N-vinyl-N-methylacetamide, methyl methacrylate, Ethylene glycol dimethacrylate, the pure and mild radical initiator of allyloxy.

2. polymerisable compound as claimed in claim 1, it further comprises ultraviolet light absorber, colorant or its combination.

3. polymerisable compound as claimed in claim 2, wherein said ultraviolet light absorber are 2-hydroxyl-4-acryloxy oxethyl-diphenyl-ketone.

4. polymerisable compound as claimed in claim 2, wherein said colorant are phthalocyanine color.

5. as the described polymerisable compound of arbitrary claim in the claim 1 to 4, wherein said radical initiator is 2,2 '-azoisobutyronitrile.

6. as the described polymerisable compound of arbitrary claim in the claim 1 to 5, it comprises one or more following each things: (i) α-ω of about 34 weight %-two (methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyls)-poly-(dimethyl siloxane)-poly-(trifluoro propyl methylsiloxane)-poly-(ω-methoxyl-poly-(ethylene glycol) propyl group methylsiloxane), N-vinyl-N-methylacetamide of (ii) about 46 weight %, the methyl methacrylate of (iii) about 17 weight %, the Ethylene glycol dimethacrylate of (iv) about 0.5 weight %, (the allyloxy alcohol of v) about 1 weight %.

7. as the described polymerisable compound of arbitrary claim in the claim 1 to 6, it further comprises one or more following each things: (the 2-hydroxyl of vi) about 0.9 weight %-4-acryloxy oxethyl-diphenyl-ketone, (phthalocyanine blue of vii) about 0.1 weight % and the (radical initiator of viii) about 0.3 weight %.

8. polymerisable compound as claimed in claim 1, it comprises α-ω-two (methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyls)-poly-(dimethyl siloxane)-poly-(trifluoro propyl methylsiloxane)-poly-(ω-methoxyl-poly-(ethylene glycol) propyl group methylsiloxane) of about 34 weight %, N-vinyl-N-methylacetamide of about 46 weight %, the methyl methacrylate of about 17 weight %, the Ethylene glycol dimethacrylate of about 0.5 weight %, the allyloxy alcohol of about 1 weight %, the 2-hydroxyl of about 0.9 weight %-4-acryloxy oxethyl-diphenyl-ketone, 2,2 of the phthalocyanine blue of about 0.1 weight % and about 0.3 weight % '-azoisobutyronitrile.

9. as the described polymerisable compound of arbitrary claim in the claim 1 to 8, wherein do not exist polyalkylene oxidation silicon can extract component.

10. silicone hydrogel contact lens, it is by making as the described polymerisable compound of arbitrary claim in the claim 1 to 9.

11. a silicone hydrogel contact lens, it is by forming as the described composition of arbitrary claim in the claim 1 to 9, and it does not have in fact can extract component.

12. a silicone hydrogel contact lens, it comprises the reaction product as the described composition of arbitrary claim in the claim 1 to 9.

13. silicone hydrogel contact lens, it makes by following steps: the described polymerisable compound of arbitrary claim comprises the extraction pre-polymerization silicone hydrogel contact lens that can extract component in polymerization such as the claim 1 to 9 with formation, contact lenses before described extraction extract the described component that extracts with the polymerization glasses product of formation through extraction, and the described polymerization glasses product through extracting of hydration is to form silicone hydrogel contact lens.

14. silicone hydrogel contact lens as claimed in claim 13, it has equilibrium water content and the oxygen permeability (D in about 80-100 Barre (barrer) scope to about 50 weight % scopes at about 42 weight % _k* 10 ^-11).

15. as claim 13 or 14 described silicone hydrogel contact lens, it has about modulus of 0.6 to about 1.2MPa.

16. silicone hydrogel contact lens as claimed in claim 13, wherein said polymerization comprise described polymerisable compound is heated to greater than about 55 ℃ temperature.

17. silicone hydrogel contact lens as claimed in claim 13, it has at the equilibrium water content of about 42 weight % to about 50 weight % scopes, the oxygen permeability (D in about 80-100 Barre scope _k* 10 ^-11), about modulus of 0.6 to about 1.2MPa, about 2-5 (* 10 ^-3Mm ²/ min) ion flow, about 52 ° to about 62 ° advancing contact angles, about 40 ° to 60 ° receding contact angle and about 5 ° to about 15 ° hysteresis.

18. one kind is not surface treated as the described silicone hydrogel contact lens of arbitrary claim in the claim 10 to 17.

19. method that produces polymerizable silicone hydrogel contact lens precursor composition, described method comprises: combination α-ω-two (methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyls)-poly-(dimethyl siloxane)-poly-(trifluoro propyl methylsiloxane)-poly-(ω-methoxyl-poly-(ethylene glycol) propyl group methylsiloxane), N-vinyl-N-methylacetamide, methyl methacrylate, Ethylene glycol dimethacrylate, the pure and mild radical initiator of allyloxy, and to produce polymerizable silicone hydrogel contact lens precursor composition thus.

20. method as claimed in claim 19 further comprises ultraviolet light absorber in described combination step, colorant, or its combination.

21. method as claimed in claim 20, wherein said ultraviolet light absorber are that 2-hydroxyl-4-acryloxy oxethyl-diphenyl-ketone and described colorant are phthalocyanine color.

22. as the described method of arbitrary claim in the claim 19 to 21, wherein said combination step comprises combination:

(i) α-ω of about 30-40 weight %-two (methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyls)-poly-(dimethyl siloxane)-poly-(trifluoro propyl methylsiloxane)-poly-(ω-methoxyl-poly-(ethylene glycol) propyl group methylsiloxane),

N-vinyl-N-methylacetamide of (ii) about 40-50 weight %,

The methyl methacrylate of (iii) about 10-25 weight % and

23. method as claimed in claim 22, wherein said combination step comprises α-ω-two (methacryloxyethyl imino-carboxyl group ethoxycarbonyl propyls)-poly-(dimethyl siloxane)-poly-(trifluoro propyl methylsiloxane)-poly-(ω-methoxyl-poly-(ethylene glycol) propyl group methylsiloxane) that makes up about 34 weight %, N-vinyl-N-methylacetamide of about 46 weight %, the methyl methacrylate of about 17 weight %, the Ethylene glycol dimethacrylate of about 0.5 weight %, the allyloxy alcohol of about 1 weight %, the 2-hydroxyl of about 0.9 weight %-4-acryloxy oxethyl-diphenyl-ketone, 2,2 of the phthalocyanine blue of about 0.1 weight % and about 0.3 weight % '-azoisobutyronitrile.

24. as the described method of arbitrary claim in the claim 19 to 23, it further comprises the described polymerizable glasses of polymerization precursor composition to form the preceding polymerization silicone hydrogel contact lens of extraction.

25. method as claimed in claim 24, it is positioned over described polymerizable glasses precursor composition in the non-polar resin contact lens molds before further being included in described polymerization.

26. method as claimed in claim 25, there is not the polymerization glasses product through extraction that can extract component in fact in its polymerization contact lenses that further comprise before the described extraction of extraction to form, and

The described polymerization glasses product through extracting of hydration is to form silicone hydrogel contact lens.