CN101468206A - Virus inactivating device for in vivo blood with extracorporeal circulation - Google Patents
Virus inactivating device for in vivo blood with extracorporeal circulation Download PDFInfo
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- CN101468206A CN101468206A CNA2008100005438A CN200810000543A CN101468206A CN 101468206 A CN101468206 A CN 101468206A CN A2008100005438 A CNA2008100005438 A CN A2008100005438A CN 200810000543 A CN200810000543 A CN 200810000543A CN 101468206 A CN101468206 A CN 101468206A
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- illumination
- extracorporeal circulation
- blood
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- virus inactivating
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Abstract
The present invention discloses a virus blanching device of extracorporeal circulation in-vivo blood, which belongs to the blood irradiation device in a natural loop bypass system, or a device of applied chemical substance and irradiation. The device of the invention is formed to an illumination barrel which is provided with a break at on side and is provided with a tubular light irradiation cavity at the inner part for according the pipeline which takes the virus blood plasma and photosensitive agent in vivo. The illumination barrel is formed with an inner wall which is provided with array illumination holes and an annular space which is combined with the casing and forms an inner part. A plurality of excitation light sources which are connected through conducting wires are respectively installed on the array illumination holes of inner wall. The excitation light sources and photosensitive agent in the pipeline generate photochemical reaction. The generated singlet oxygen or free radial oxidize and damage the molecular structure of virus thereby blanching the virus. Therefore the in-vivo blood after virus blanching directly enter the human body thereby greatly increasing the virus blanching effect and efficiency and reaching the requirement of clinical remedy.
Description
Technical field
The present invention relates to the irradiation devices of blood in the Natural Circulation bypath system, or the device of applied chemistry material and irradiation, specifically be the virus inactivating device of a kind of extracorporeal circulation at body blood.
Background technology
At present, the method that virus (as viruses such as hepatitis, AIDS, SARS) in the extracorporeally circulating blood is carried out deactivation of prior art mainly is to use singlet oxygen or the free-radical oxidation damage viruses molecule structure that photosensitizer produces under illumination, thereby the principle of inactivation of virus is realized.
Chinese patent 1565654 discloses a kind of " virus inactivating method and application thereof in the extracorporeally circulating blood ", and it comprises the steps: 1) add anticoagulant in the full blood, set up the full blood blood circulation; 2) with anticoagulated whole blood suction plasma separating unit, after the separation, the direct blowback full blood of erythrocyte, blood plasma enters the mixing delivery pump; 3) in mixing delivery pump, add simultaneously the photosensitizer methylene blue, methylene blue with pump into the blood plasma container after blood plasma mixes; 4) illumination meter carries out the illumination deactivation to blended blood plasma in the blood plasma container, quick dose of removal device of blood plasma pump light inlet after the deactivation; 5) photosensitizer removal device absorption methylene blue, blood plasma is drawn back full blood after the deactivation; 6) repeating step 2) to step 5), viral level reduces by 99.99% in full blood.The present invention can be in bulk, flowing water and circular treatment blood, uses aseptic and disposable closed system that be isolated from the outside is handled, and the blood plasma after the processing is got back to full blood, can be directly used in to be transported to organism.
Chinese patent 2631512 discloses " the online circulation inactivating device of plasma viral ", comprises illumination meter, and the blood plasma container that is placed in one places the blood plasma container to advance pump before the blood vessel, and the photosensitizer removal device after the blood vessel of going out that places the blood plasma container.Illumination meter comprises supporting plate, luminous plaque, heat sink, fan, its front has increased pump, blood plasma and photosensitizer can conveniently be mixed and by carrying out inactivation of virus in the demand speed input illumination meter, back line adding photosensitizer removal device remains in photosensitizer in the blood plasma with absorption.So, the blood plasma after the processing can be directly used in and be transported to organism; And, simplified the loaded down with trivial details operation of blood plasma deactivation, can be in bulk, flowing water and circular treatment blood plasma, realize that real-time online carries out inactivation of virus to blood plasma.
Chinese patent 2664661 is disclosed to be " disposable blood virus inactivating device ", it comprises slash pocket pin, illumination bag, blood storage bag, virus inactivating agent adder and adsorption filter, the virus inactivating agent adder comprises the glass tubing that solid-state virus inactivating agent is housed and is encapsulated in the plug and the built-in needle for inserting bottle at glass tubing two that what solid-state virus inactivating agent was used is that photosensitizer solution is formed fluffy solid-state photosensitizer through lyophilization or low-temperature vacuum drying.Adopt glass tubing and butyl rubber plug again, not adsorption of solid state photosensitizer and good seal performance, but so long preservation, the photosensitizer stable content does not decompose, fluffy solid-state photosensitizer can be dissolved in the blood that needs deactivation rapidly in use, can carry out damp and hot high temperature sterilize sterilization with package unit during production, guarantee the cleanliness factor of whole device, be convenient to large-scale popularization and use.
Chinese patent 2677914 also discloses a kind of " photochemistry TRAP illumination meter ", and it comprises casing and light source, and feature is that cabinet wall periphery and bottom surface are provided with specular layer; At least two light sources are set up in parallel in box cavity; The sample platform is set between light source.It is applicable to that (Superoxide dismutase, SOD) photochemistry enlarges the instrument of measuring the spectrochemical analysis of using to superoxide dismutase.
But, though existing method to the inactivation of virus in the extracorporeally circulating blood also is to have adopted extracorporeal circulation apparatus, but must at first blood will be extracted out from human body and with its separation, then blood plasma is pumped into the blood plasma container, shine being in static blood plasma in the container this moment again.In addition, existing method only after repeating said process continuously, just may reach the height deactivation to virus.So said method is the program complexity not only, and can not directly carry out the deactivation of virus to the blood that is in the body dynamic circulation.
Summary of the invention
The present invention is exactly in order to solve being in the blood in the dynamic circulation, can not directly to carry out the technical problem of extracorporeal circulation inactivation of virus in body blood, and the virus inactivating device of a kind of extracorporeal circulation at body blood is provided.
The present invention realizes by following technical scheme.
A kind of extracorporeal circulation is at the virus inactivating device of body blood, the connection lead and the excitation source that comprise setting, in order to be contained in the pipeline of dynamic slurry of toxenia in spite of illness of body and photosensitizer, this device is that a side is formed with gap, is the illumination cylindrical shell in tubular light irradiation chamber in it, the illumination cylindrical shell is formed with the inwall in array illumination hole and shell and is combined as a whole and constitutes inner annulus, the a plurality of excitation sources that connect through lead are set in the annulus, and excitation source is separately positioned on the array illumination hole of inwall.
And what be provided with on the array illumination hole is that the wavelength and the photosensitizer in the pipeline of its light wave produces photochemically reactive excitation source.
She Ji the present invention like this, its beneficial effect be used for clinical, promptly directly concrete patient (patients such as hepatitis, AIDS, SARS) is carried out shining in the extracorporeal circulation of body blood, make the blood behind the inactivation of virus directly enter human body, compare with the ablation method of virus in the traditional extracorporeally circulating blood, do not need blood of human body is extracted out and can be handled systemic blood, improve inactivation of virus effect and efficient greatly, make it reach the requirement of clinical treatment.
Description of drawings
Fig. 1 is a structural representation of the present invention;
Fig. 2 is an interior wall construction sketch map of the present invention;
Fig. 3 is a shell mechanism sketch map of the present invention;
Fig. 4 is the structural representation of another embodiment of the present invention;
Fig. 5 is a user mode structural representation of the present invention;
Fig. 6 is the cross section structure sketch map of another embodiment of the present invention.
Fig. 7 is an electrical block diagram of the present invention.
Among the figure: 1. pipeline 2. gap
3. tubular light irradiation chamber 4. illumination cylindrical shells
5. array illumination hole 6. inwalls
7. shell 8. annuluses
9. lead 10. excitation sources
11. outer turned welt is along 12. gap walls
13. carriage 14. plastic cement diaphragm circuit boards entad
15. lead fairlead 16. fixing holes
17. supporting plate.
The specific embodiment
The present invention will be described in detail below in conjunction with drawings and Examples.
A kind of extracorporeal circulation is at the virus inactivating device of body blood, the connection lead and the excitation source that comprise setting, in order to be contained in the pipeline 1 of dynamic slurry of toxenia in spite of illness of body and photosensitizer, this device is that a side is formed with gap 2, is the illumination cylindrical shell 4 in tubular light irradiation chamber 3 in it, the inwall 6 that the illumination cylindrical shell is formed with array illumination hole 5 is combined as a whole with shell 7 and constitutes inner annulus 8, the a plurality of excitation sources 10 that connect through lead 9 are set in the annulus, and excitation source is separately positioned on the array illumination hole 5 of inwall.Be formed with lead fairlead 15 on the shell 7.
The illumination cylindrical shell in described tubular light irradiation chamber is that the cross section is the illumination cylindrical shell in the round tubular photoirradiation chamber of band gap; Or square, or the illumination cylindrical shell (not shown) in hexagon tubulose photoirradiation chamber.
The integrally formed outer turned welt in inwall 6 tops of illumination cylindrical shell 4 is along 11, and the corresponding invagination in the gap limit of shell 7 forms gap wall 12, the bottom of shell 7 be formed with support inwall and circuit board "
" shape carriage 13 entad.
Described extracorporeal circulation is at the virus inactivating device of body blood, and it constitutes inner annular space 8 and the inwall 6 in array illumination hole 5 is arranged is integrally formed with shell 7.
Described extracorporeal circulation is at the virus inactivating device of body blood, and its gap 2 is axially consistent with the illumination cylindrical shell 4 that forms tubular light irradiation chamber 3.
Described extracorporeal circulation is at the virus inactivating device of body blood, and what be provided with on its array illumination hole 5 is that the wavelength and the photosensitizer in the pipeline of its light wave produces photochemically reactive excitation source 10.The wave-length coverage of described excitation source 10 is 400nm-700nm.
Described extracorporeal circulation is at the virus inactivating device of body blood, and wavelength and the photosensitizer in the pipeline that its excitation source 10 that is arranged on the array illumination hole 5 is light waves produce photochemically reactive excitation source.
Described extracorporeal circulation is at the virus inactivating device of body blood, and it is LD or LED that a plurality of excitation sources 10 that connect through lead 9 are set in its annulus 8.
Described extracorporeal circulation is at the virus inactivating device of body blood, and gap 2 width that its illumination cylindrical shell 4 one sides form are less than the external diameter of pipeline 1.
Described extracorporeal circulation is at the virus inactivating device of body blood, its lead 9 serial connections or and connect excitation source 10, described lead 9 is arranged on the plastic cement diaphragm circuit board 14, is convenient to the conformal bending.
Described extracorporeal circulation is at the virus inactivating device of body blood, and its content pipeline 2 of toxenia slurry and photosensitizer in spite of illness is to make the light wave of irradiation and the photosensitizer in the pipeline produce photochemically reactive medical lucite pipe.
Described extracorporeal circulation is at the virus inactivating device of body blood, and the position of corresponding gap 2 is provided with the supporting plate 17 that is formed with fixing hole 16 on its illumination cylinder shell 7.
Use when lacking filter folder (not shown) for ease of extracorporeal circulation of blood machine plate, through fixing hole 16 supporting plate 17 is fixed on extracorporeal circulation of blood machine plate (not shown) with screw and upward gets final product.
The supporting plate 17 that is formed with array illumination hole 5 inwalls 6, shell 7 and is formed with fixing hole 16 of illumination cylindrical shell 4 adopts the medical non-toxic plastic injection mo(u)ldings.Also can adopt aluminum alloy materials to process.The inwall 6 that split forms is rabbeted with shell 7 tops along 11 by outer turned welt, or bonding being integral.
Use when of the present invention, utilize each device on the extracorporeal circulation of blood machine as the prerequisite of this working procedure.Push the handle of filter folder (not shown) on the extracorporeal circulation of blood machine, pressing plate is lifted, the illumination cylindrical shell 4 that forms tubular light irradiation chamber is fixed in the filter folder; To be power source with the peristaltic pump again, connect the hemocyte filter, and with content in spite of illness the blood plasma pipe 1 tunnel of toxenia slurry and photosensitizer in gap 2 pinchings are placed in the tubular light irradiation chamber 3 of illumination cylindrical shell 4; Energized is arranged on excitation source 10 on the array illumination hole 5 and shines the pipeline 1 of toxenia slurry and photosensitizer in spite of illness, singlet oxygen that photosensitizer produces under illumination or free-radical oxidation damage viruses molecule structure, thereby with inactivation of virus.For preventing that pipeline 1 from deviating from from gap 2, can gap 2 be got final product towards extracorporeal circulation of blood machine plate with the illumination cylindrical shell 4 in tubular light irradiation chamber at filter folder internal rotation.
Claims (9)
1. an extracorporeal circulation is at the virus inactivating device of body blood, the connection lead and the excitation source that comprise setting, it is characterized in that, in order to be contained in the pipeline of dynamic slurry of toxenia in spite of illness of body and photosensitizer, this device is that a side is formed with gap, is the illumination cylindrical shell in tubular light irradiation chamber in it, the illumination cylindrical shell is formed with the inwall in array illumination hole and shell and is combined as a whole and constitutes inner annulus, the a plurality of excitation sources that connect through lead are set in the annulus, and excitation source is separately positioned on the array illumination hole of inwall.
2. according to the virus inactivating device of the described extracorporeal circulation of claim 1 at body blood, the integrally formed outer turned welt edge, inwall top that it is characterized in that the illumination cylindrical shell, the corresponding invagination in the gap limit of shell forms the gap wall, and the bottom of shell is formed with the entad carriage of supporting inwall and circuit board.
3. according to the virus inactivating device of the described extracorporeal circulation of claim 1 at body blood, it is integrally formed it is characterized in that constituting the inner annular space and the inwall in array illumination hole and shell being arranged.
4. according to the virus inactivating device of the described extracorporeal circulation of claim 1, it is characterized in that gap and the illumination drum shaft that forms tubular light irradiation chamber are to consistent at body blood.
5. according to the virus inactivating device of the described extracorporeal circulation of claim 1 at body blood, the wavelength and the photosensitizer in the pipeline that it is characterized in that being arranged on excitation source on the array illumination hole and be light wave produce photochemically reactive excitation source.
6. according to the virus inactivating device of the described extracorporeal circulation of claim 1, it is characterized in that it is LD or LED that a plurality of excitation sources that connect through lead are set in the annulus at body blood.
7. according to the virus inactivating device of the described extracorporeal circulation of claim 1, it is characterized in that the external diameter of the gap width of illumination cylindrical shell one side formation less than pipeline at body blood.
8. according to the virus inactivating device of the described extracorporeal circulation of claim 1, it is characterized in that the position of corresponding gap on the illumination cylinder shell is provided with the supporting plate that is formed with fixing hole at body blood.
9. according to the virus inactivating device of the described extracorporeal circulation of claim 1, it is characterized in that the lead that connects excitation source is arranged on the plastic cement diaphragm circuit board at body blood.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100005438A CN101468206A (en) | 2007-12-29 | 2008-01-21 | Virus inactivating device for in vivo blood with extracorporeal circulation |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710060555 | 2007-12-29 | ||
| CN200710060555.5 | 2007-12-29 | ||
| CNA2008100005438A CN101468206A (en) | 2007-12-29 | 2008-01-21 | Virus inactivating device for in vivo blood with extracorporeal circulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101468206A true CN101468206A (en) | 2009-07-01 |
Family
ID=40101885
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2008200007231U Expired - Lifetime CN201154094Y (en) | 2007-12-29 | 2008-01-21 | Virus inactivating device for blood of extracorporeal circulation in vivo |
| CNA2008100005438A Pending CN101468206A (en) | 2007-12-29 | 2008-01-21 | Virus inactivating device for in vivo blood with extracorporeal circulation |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2008200007231U Expired - Lifetime CN201154094Y (en) | 2007-12-29 | 2008-01-21 | Virus inactivating device for blood of extracorporeal circulation in vivo |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN201154094Y (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110101928A (en) * | 2019-05-29 | 2019-08-09 | 刘忠英 | One kind is in body closed loop sterilizing installation |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010141564A2 (en) * | 2009-06-02 | 2010-12-09 | Ceramoptec Industries, Inc. | A novel method for microbial depletion in human blood and blood products using antimicrobial photodynamic therapy |
| CN104548233B (en) * | 2013-10-23 | 2018-05-08 | 国医华科（深圳）医疗科技发展有限公司 | A kind of blood irradiator |
| CN111481764A (en) * | 2020-05-12 | 2020-08-04 | 上海慧勤医疗器械有限公司 | Virus inactivation device and method for blood extracorporeal circulation |
-
2008
- 2008-01-21 CN CNU2008200007231U patent/CN201154094Y/en not_active Expired - Lifetime
- 2008-01-21 CN CNA2008100005438A patent/CN101468206A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110101928A (en) * | 2019-05-29 | 2019-08-09 | 刘忠英 | One kind is in body closed loop sterilizing installation |
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| Publication number | Publication date |
|---|---|
| CN201154094Y (en) | 2008-11-26 |
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Application publication date: 20090701 |