CN101461943A - Micropore ceramics and method for sustained-release of medicament or biological preparation and use thereof - Google Patents
Micropore ceramics and method for sustained-release of medicament or biological preparation and use thereof Download PDFInfo
- Publication number
- CN101461943A CN101461943A CNA2008102051093A CN200810205109A CN101461943A CN 101461943 A CN101461943 A CN 101461943A CN A2008102051093 A CNA2008102051093 A CN A2008102051093A CN 200810205109 A CN200810205109 A CN 200810205109A CN 101461943 A CN101461943 A CN 101461943A
- Authority
- CN
- China
- Prior art keywords
- micropore
- ceramics
- medicine
- slow release
- micropore ceramics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention relates to microporous ceramics capable of slowly releasing medicines and biological agents, a method for preparing the same and application thereof. By utilizing the slow release effect of the microporous biological ceramics and accurately controlling the size and density of micropores, microporous biological ceramic products with different forms, structures and sizes are prepared; and the medicines and the biological agents are loaded in the microporous biological ceramic products. In the method, a ceramic blank is added with a soluble or volatile fine grain, or the size of ceramic power grains is controlled, or the sintering temperature is controlled, so that the size and density of the micropores, which are required in design, are formed in the biological ceramics. By the mold pressing method and the grouting method, products with different forms, structures and sizes can be prepared; furthermore, the single microporous ceramics, microporous/porous composite ceramics, microporous/compact substance composite ceramics, or microporous/porous/compact substance composite ceramics can be prepared; and the effects of medicine storage and slow release are achieved by the micropore, and the double biological reconstruction of bone defect and slow release of the medicine is completed.
Description
Technical field
The present invention relates to a kind of micropore ceramics, method and application thereof that makes medicine and biological preparation slow release.The major function of described micropore ceramics is: 1) utilize the lacuna of pottery to embody the drug storage function; 2) utilize the micropore of pottery to express slow releasing function; 3) utilize the configuration and the intensity of pottery to reach the reconstruction effect.Belong to the bioceramic field.
Technical background
In the human body device matter disease, it is local patholoic change that a sizable part is arranged.Traditional therapy is by oral, arteriovenous and anorectal administration, but most of medicine is lost by human organ, and therapentic part does not reach corresponding concentration.So just force to give the super large dosed administration, can reach the effect of treatment certainly, but the toxicity of medicine and side effect are immeasurable to the infringement of human organ that some can cause irreversible organ injury, especially liver, kidney, brain and the heart.Recent two decades comes, and scientist and doctors strive to find the new way of topical, by and invented " interventional therapy ", promptly application catheter conducts drugs to diseased region by tremulous pulse, receives good effect.But taken away by blood flow because medicine is very fast, very short in partial action time.Interventional procedure is very loaded down with trivial details repeatedly, the cost costliness, and can bring certain life danger to patient.This proposes a new challenge to medical circle again, medicine should be placed on the permanently effective release of diseased region, thereby form " slow release " medicine and utensil.
The medicament slow release effect usually is by organic and inorganic material technologies such as medicine absorption, mixing embedding and core parcel to be finished.Polylactic acid and copolymer thereof can be made related dose forms according to character, release request and the route of administration of medicine.Main adopt methods such as solution molding, hot pressing be in blocks to prepare some slow releasing pharmaceuticals, as insulin polylactic acid double-layer sustained release tablets, gentamycin polylactic acid cylinder, the block implant of pig GRH, the hollow acid fiber by polylactic agent of hormone left side norethindrone etc., polylactic acid also can be made into multiple dosage forms such as some thin film, class Emulsion to reach the effect of controlled release drug.The research focus is the power chemical medicine thing preparation for preparing comparatively complicated effectively controlled release and energy targeted therapy at present, as stratiform microgranule, microsphere, microcapsule and nanoparticle etc.The compound amycin slow release of chitosan medicine grain is implanted rabbit tibia epimere and is contrasted with the administration of vein same dose, keeps high concentration and can reach for 8 weeks in osseous tissue, and content is 29 times of matched group, plasma peaks be its 1/13.Leachate can reach 58.11% on the 1st day to the growth inhibition ratio of osteosarcoma cell line, still had 21.62% at the 60th day.Find that in clinical practice preliminary observation follow up a case by regular visits to 7～19 months no local recurrence, hepatic and renal function is no abnormal to giant cell tumor of bone.Use tricalcium phosphate pottery and hydroxylapatite ceramic, prepare apatite Ceramic Composite MTX drug-loading system with centrifugal, under the same conditions, tricalcium phosphate pottery drug loading is higher than hydroxyapatite, the release level is more stable, concentration is higher, and both drug level all can maintain 0.1～1.0 μ g/ml and reach 12 days.Take all factors into consideration from drug loading, release level and concentration three aspects, as drug-loading system, the tricalcium phosphate pottery more is better than hydroxyapatite.Another studies show that the external release of amycin composite hydroxylapatite implantation slow release agent peaked at the 4th day, and drug releasing rate is very fast in 14 days, and concentration is greater than 1 μ g/ml, and drug level still is higher than IC50 (IC50=0.35) in 40 days.Implant in the rat muscle, local drug concentration maintains higher level in 4 weeks, and Liver and kidney Chinese medicine concentration is respectively 3% and 6% of implant site when first week, after this between 0.2%～1%, blood plasma Chinese medicine concentration does not almost detect, and confirms that this implant whole body toxic and side effects is light.The implantation tumour part can significantly reduce tumor propagation rate and rate of rise, and the neoplasm necrosis zone is 3 times of implant volume.Amycin distributes in tissue and is by the implant center to periphery, and graded from high to low, effective range are 4～8 times of implant volume.
The curative effect of slow releasing pharmaceutical has obtained certainly at present, but, that slow releasing pharmaceutical is made is complicated, cost an arm and a leg, medicine damage amount reaches unfavorable factors such as drug capacity in the slow releasing agent is limited greatly, can influence the activity of biological preparation in addition, can not reach the reconstruction effect of tissue and organ.The present invention will utilize the lacuna of pottery to embody the drug storage function, and the micropore of pottery is expressed slow releasing function, and the configuration and the intensity of pottery reach the reconstruction effect.
Summary of the invention
The object of the present invention is to provide a kind of micropore ceramics, method and application thereof that makes medicine or biological preparation slow release.The present invention can pass through ceramic capillary (aperture is less than 10 microns) release according to medicine of finding under study for action and biological preparation, and micropore size and density can directly influence their throughput and speed.This two key element is regulated in this prompting just can reach the effect of control medicament slow release.
The present invention utilizes the slow releasing function of micropore bioceramic to medicine, by accurate control micropore size and density, the micropore bioceramic goods of preparation different shape, structure and size with medicine and biological preparation loading or wherein compound, are applied to the required therapentic part of patient subsequently.The major function of these micropore ceramics goods is: 1) utilize the lacuna in the pottery to embody the drug storage function, make in the medicine dress storage pottery of sufficient dosage, reach treatment required dosage and cycle; 2) utilize the micropore of pottery to express slow releasing function, make medicine and biological preparation energy controllable sustained-release, in human body, reasonably discharge, reach local application and reduce side effect according to the treatment demand; 3) utilize the configuration and the intensity of pottery to reach the reconstruction effect, make it play filling, support, rebuild and guide effect at diseased region, this is especially even more important to the bone structure position.
Micropore ceramics provided by the invention is cylindrical micropore ceramics box, and it is to be made of cylindrical micropore ceramics box and the lid that matches; One drug storage chamber is arranged in cylindrical micropore ceramics box, and the drug storage top of chamber has a medicine-pouring hole that communicates with the drug storage chamber, and medicine or biological preparation are loaded in the cavity;
Described drug storage chamber is micropore ceramics or porous ceramics, is built into single micropore ceramics respectively or is built into micropore ceramics and the composite ceramics of porous ceramics; The aperture of described porous ceramics is greater than 100 microns;
Described drug storage intracavity has a compact substance pottery, is built into the composite ceramics of micropore ceramics and compact substance pottery or is built into the composite ceramics of micropore ceramics, porous ceramics and compact substance pottery.
The present invention accurately is produced on micropore among the bioceramic, its method is to add solubility or the volatile granule becomes the micropore agent in the blank of pottery, or control ceramic powder granular size, or the control sintering temperature, reach the micropore size and the density that in bioceramic, form designing requirement.And can adopt die pressing or slip casting method to prepare different shape, structure and size.
Particularly, the technological process of medicine of the present invention and biological preparation slow release micropore ceramics:
1) selects corresponding ceramic powder and as the organic granular of micropore agent;
2) make corresponding mould according to shape of product and size;
3) ceramic powder or ceramic powder are added entry, dispersant and binding agent by a certain percentage with becoming the micropore agent, be mixed with serosity through stirring;
4) with slurry filling in mould, dry forming, the demoulding and finishing obtain ceramic body;
5) or with ceramic powder or ceramic powder make ceramic body at mould inner pressure with becoming the micropore agent composition;
6) base substrate is moved in the binder removal stove, be warming up to 200-600 ℃ and remove organic substance;
7) move into subsequently in the high temperature sintering furnace, progressively be warmed to predetermined temperature, make it sinter the micropore bioceramic into.
Wherein:
1) in ceramic batch, adds solubility or the granular micropore agent of volatile, it is a class is not stayed any harmful substance behind high-temp combustion Organic substance, for example polystyrene, polyethylene, polypropylene, polrvinyl chloride, polyamide, polyurethane, polymethyl methacrylate, protein, chitin, chitosan, cellulose, saccharide and wooden carbon etc.This organic granular particle diameter is controlled in 100 nanometers to 10 micron, and addition is controlled at 0.5%-50% by volume.Behind ceramic 800-1800 ℃ sintering, former organic microgranule position will form micropore.This method can accurately be controlled micropore size and the density in the pottery.
2) make used controlled 100 nanometers to 50 of ceramic powder particle size of pottery micron.Pottery makes to form the gap between granule in sintering process, makes it not reach tight burning and forms micropore.This method can be controlled micropore size and the density in the pottery.
3) when using same granularity ceramic powder, sintering temperature is strictly controlled at the ceramic post sintering point with interior (800-1800 ℃), makes ceramic powder particle not reach tight burning and forms micropore.This method can be controlled micropore size and the density in the pottery.
4) said method can be controlled at the micropore diameter in the pottery 50 nanometers to 10 micron, and microporosity is controlled at 0.01%-50% (Fig. 1).
5) adopt die pressing or slip casting method to prepare the goods of different shape, structure and size, and can copy human dissection form and structure.
6) the present invention can prepare micropore ceramics, or micropore/porous (aperture is greater than 100 microns) composite ceramics, or micropore/fine and close composite ceramics, or micropore/porous/fine and close composite ceramics (Fig. 2).
7) there is no particular limitation to used ceramic powders in the present invention, as long as can satisfy biocompatibility, as hydroxyapatite, tricalcium phosphate, calcium carbonate, aluminium oxide, zirconium oxide, titanium dioxide, aluminum-spinel, calcium silicates etc., also their mixture.
The configuration of the micropore ceramics that utilization of the present invention provides and intensity reach the reconstruction effect, utilize the micropore of micropore ceramics to reach drug storage function and slow releasing function.
Description of drawings
Fig. 1, be the microcellular structure in the pottery that scanning electron microscope shows, the aperture is less than 10 microns (arrows).
The goods of Fig. 2, this invention have dissimilar: micropore ceramics (A), micropore/porous composite ceramics (B), micropore/compact substance composite ceramics (C) and micropore/porous/compact substance composite ceramics (D).
Fig. 3, tricalcium phosphate micropore ceramics product form and structure.
The specific embodiment
Embodiment 1:
Adopting the tricalcium phosphate of powder 1-2 micron is Ceramic Material, makes 30 millimeters of diameters and high 20 millimeters cylinder micropore ceramics box, and wall and lid are thick to be 5 millimeters (Fig. 3).Micropore diameter is at the 1-2 micron, microporosity 5%.
Concrete steps are as follows:
1) makes corresponding mould according to shape of product and size;
2) 65% ceramic powder+30% pure water+5% dispersant and binding agent were mixed with serosity in 3 hours through stirring;
3) with slurry filling in mould, be shaped in dry 10 hours, the demoulding and finishing obtain ceramic body;
4) base substrate is moved in the binder removal stove, be warming up to 370 ℃ and eliminate organic substance;
5) move in the high temperature sintering furnace, progressively be warmed to 1000 ℃, sintering becomes the micropore ceramics product after 3 hours.
Embodiment 2:
The tricalcium phosphate (85%) of employing powder 1-2 micron and the wooden carbon of 2-4 micron are as micropore agent (15%), make 30 millimeters of diameters and high 20 millimeters cylinder micropore ceramics box, 5 millimeters of wall thickness, the drug storage chamber is 20 millimeters of diameters and high 10 millimeters cylindrical, and a diameter that communicates with the drug storage chamber is arranged at the top is medicine-pouring hole (Fig. 2-A) of 0.5～1.5 millimeter.Micropore diameter is at the 1-3 micron, microporosity 15%.
Concrete steps are as follows:
1) makes corresponding mould according to shape of product and size;
2) 85% ceramic powder+15% one-tenth micropore agent was made mixture in 3 hours through stirring;
3) mixture is poured in the mould, continue compacting 30 minutes through 100MPa, the demoulding forms ceramic body;
4) base substrate is moved in the binder removal stove, be warming up to 500 ℃ and eliminate organic substance;
5) move into subsequently in the high temperature sintering furnace, progressively be warmed to 1100 ℃, sintering became the micropore ceramics product in 3 hours.
Embodiment 3:
Adopting the tricalcium phosphate of powder 2-4 micron is Ceramic Material, and the PMMA spheroidal particle of 300-500 micron is a pore creating material.Make 30 millimeters of diameters and high 20 millimeters cylinder micropore ceramics box, wall thickness is 5 millimeters, and porous ceramics drug storage chamber is 20 millimeters of diameters and high 10 millimeters cylindrical, and medicine-pouring hole (Fig. 2-B) of 1 millimeter of a diameter that communicates with the drug storage chamber is arranged at the top.The aperture 1-3 micron and the porosity 15% of micropore ceramics part.The aperture 350-450 micron and the porosity 65% of porous ceramics part.
Concrete steps are as follows:
1) makes corresponding mould according to shape of product and size;
2) the PMMA spheroidal particle is placed in the mold cavity, added acetone after 10 minutes, purified rinse water obtains cylindrical porous framework thing;
3) 65% ceramic powder+30% pure water+5% dispersant and binding agent was mixed with serosity in 3 hours through stirring;
4) porous framework thing is placed reperfusion serosity in the mold cavity, be shaped in dry 10 hours, the demoulding and finishing obtain ceramic body;
5) base substrate is moved in the binder removal stove, be warming up to 350 ℃ and eliminate organic substance;
6) move into subsequently in the high temperature sintering furnace, progressively be warmed to 900 ℃ of sintering 3 hours, form micropore/porous composite ceramics product.
Embodiment 4:
Adopting the tricalcium phosphate of powder 1-2 micron is Ceramic Material, and the wooden carbon of 2-4 micron becomes the micropore agent, and the PMMA spheroidal particle of 300-500 micron is a pore creating material.Make 30 millimeters of diameters and high 20 millimeters cylinder micropore ceramics box, tight section is 5 millimeters of diameters and high 20 millimeters cylindrical, and the micropore part is thick to be 5 millimeters, and porous part is thick to be 20 millimeters (Fig. 2-D).The aperture 1-3 micron and the porosity 15% of micropore ceramics part.The aperture 350-450 micron and the porosity 65% of porous ceramics part.
Concrete steps are as follows:
1) makes corresponding mould according to shape of product and size;
2) ceramic powder is inserted in the mould, continues compacting 30 minutes through 100MPa, forms 5 millimeters of diameters and high 20 millimeters cylindrical tight section ceramic body;
3) the PMMA spheroidal particle is placed in the mold cavity, added acetone after 10 minutes, purified rinse water obtains 5 millimeters in inner chamber footpath, 25 millimeters of external diameters and high 20 millimeters drum shape porous framework thing;
4) the wooden carbon dust grain of 56% ceramic powder+9%+30% pure water+5% dispersant and binding agent was mixed with serosity in 3 hours through stirring;
5) the tight section ceramic body is installed in the porous framework thing, is placed into reperfusion serosity in the mold cavity subsequently, be shaped in dry 10 hours, the demoulding and finishing obtain ceramic body;
6) base substrate is moved in the binder removal stove, be warming up to 500 ℃ and eliminate organic substance;
7) move into subsequently in the high temperature sintering furnace, progressively be warmed to 1100 ℃ of sintering 3 hours, form micropore/porous/fine and close composite ceramics product.
Embodiment 5:
52 years old breast carcinoma postoperative of women 2 years found the second lumbar vertebra metastatic carcinoma.Implement the full vertebral resection postoperative of second lumbar vertebra, inject anticarcinogen cisplatin 400mg, it is installed in bone defect location behind the tumor resection, finish dual biological reconstruction of the damaged and medicament slow release of bone at the infrastructure product drug storage intracavity of embodiment 3.Add with strong internal fixation in the spinal column way of escape subsequently.Followed up a case by regular visits to after the operation 2 years, and do not find tumor local recur, patient's disease free survival.
Present embodiment proves absolutely the configuration of utilizing micropore ceramics, reaches drug storage and slow releasing function.
Claims (10)
1, a kind of micropore ceramics that makes medicine or biological preparation slow release, it is characterized in that described micropore ceramics is to utilize the slow releasing function of micropore ceramics to medicine or biological preparation, by control micropore size and density, prepare the micropore bioceramic goods of different shape, structure and size, with medicine and biological preparation loading or wherein compound, be applied to the required therapentic part of patient subsequently.
2, by the described micropore ceramics that makes medicine or biological preparation slow release of claim 1, the aperture that it is characterized in that described micropore bioceramic is 50nm～10 μ m, and microporosity is 0.01～50%.
3, by the described micropore ceramics that makes medicine or biological preparation slow release of claim 1, it is characterized in that micropore ceramics is the pottery that satisfies biocompatibility, they are hydroxyapatite, tricalcium phosphate, calcium carbonate, aluminium oxide, zirconium oxide, titanium dioxide, aluminum-spinel or calcium silicates and their mixture.
4, by claim 1, the 2 or 3 described micropore ceramics that make medicine or biological preparation slow release, it is characterized in that described micropore ceramics is cylindrical micropore ceramics box, it is to be made of cylindrical micropore ceramics box and the lid that matches; One drug storage chamber is arranged in cylindrical micropore ceramics box, and the drug storage top of chamber has a medicine-pouring hole that communicates with the drug storage chamber, and medicine or biological preparation are loaded in the cavity.
5, by the described micropore ceramics that makes medicine or biological preparation slow release of claim 4, it is characterized in that described drug storage chamber is micropore ceramics or porous ceramics, be built into single micropore ceramics respectively or be built into micropore ceramics and the composite ceramics of porous ceramics; The aperture of described porous ceramics is greater than 100 microns.
6, by the described micropore ceramics that makes medicine or biological preparation slow release of claim 4, it is characterized in that described drug storage intracavity has a compact substance pottery, be built into the composite ceramics of micropore ceramics and compact substance pottery or be built into the composite ceramics of micropore ceramics, porous ceramics and compact substance pottery.
7, by the described micropore ceramics that makes medicine or biological preparation slow release of claim 4, the diameter that it is characterized in that described cylindrical micropore ceramics box is 30 millimeters, highly is that 20 millimeters, wall thickness are 5 millimeters cylindrical; The diameter in described drug storage chamber is 20 millimeters, highly is 10 millimeters, and the medicine-pouring hole diameter of drug storage top of chamber is 0.5～1.5 millimeter.
8, preparation is as each described method that makes the micropore ceramics of medicine or biological preparation slow release in the claim 1～3, it is characterized in that in the blank of pottery, adding solubility or volatile granule as the micropore agent, or control ceramic powder granular size, or control sintering temperature, reach the micropore size and the density that in bioceramic, form designing requirement, adopt die pressing or slip casting method to prepare different shape, structure and size, concrete feature is as follows:
1) selects corresponding ceramic powder and as the organic granular of micropore agent;
2) make corresponding mould according to shape of product and size;
3) ceramic powder or ceramic powder are added entry, dispersant and binding agent by a certain percentage with becoming the micropore agent, be mixed with serosity through stirring;
4) with slurry filling in mould, dry forming, the demoulding and finishing obtain ceramic body;
5) or with ceramic powder or ceramic powder make ceramic body at mould inner pressure with becoming the micropore agent composition;
6) base substrate is moved in the binder removal stove, be warming up to 200-600 ℃ and remove organic substance;
7) be transplanted to then in the high temperature sintering furnace, progressively be warmed to predetermined temperature, fired microporous bioceramic.
9, by the described preparation method that makes the micropore ceramics of medicine or biological preparation slow release of claim 8, it is characterized in that:
(1) described organic granular as the micropore agent is polystyrene, polyethylene, polypropylene, polrvinyl chloride, polyamide, polyurethane, polymethyl methacrylate, protein, chitin, chitosan, cellulose, saccharide or wooden carbon; Described organic granular particle diameter is controlled at 100 nanometers to 10 micron, and addition by volume percentage ratio be controlled at 0.5%-50%; Behind 800-1800 ℃ of sintering, original organic fine particles position forms micropore at ceramic powder, thereby accurately controls micropore size and density in the pottery;
(2) make used controlled 100 nanometers to 50 of ceramic powder particle size of pottery micron; Pottery makes to form the gap between granule in sintering process, makes it not reach tight burning and forms micropore; Thereby micropore size and density in the control pottery;
(3) when using same granularity ceramic powder, sintering temperature is strictly controlled at below the ceramic sintering temperature, is 800-1800 ℃, makes ceramic powder particle not reach tight burning and forms micropore, thereby can control ceramic interior micropore size and density.
10, by claim 1,4, the 5 or 6 described application that make the micropore ceramics of medicine or biological preparation slow release, it is characterized in that utilizing the configuration of micropore ceramics and intensity to reach the reconstruction effect, utilize micropore to reach drug storage function and slow releasing function, finish bone dual biology damaged and medicament slow release and rebuild.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008102051093A CN101461943A (en) | 2008-12-30 | 2008-12-30 | Micropore ceramics and method for sustained-release of medicament or biological preparation and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008102051093A CN101461943A (en) | 2008-12-30 | 2008-12-30 | Micropore ceramics and method for sustained-release of medicament or biological preparation and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101461943A true CN101461943A (en) | 2009-06-24 |
Family
ID=40802878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008102051093A Pending CN101461943A (en) | 2008-12-30 | 2008-12-30 | Micropore ceramics and method for sustained-release of medicament or biological preparation and use thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101461943A (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101962298A (en) * | 2010-04-20 | 2011-02-02 | 无锡南理工科技发展有限公司 | Method for preparing light nano porous ceramics |
| CN104586818A (en) * | 2013-11-01 | 2015-05-06 | 北京中卫神农慢性病医学研究院有限公司 | Micro-porous capsicine sustained-release apparatus |
| CN105194727A (en) * | 2014-06-04 | 2015-12-30 | 卢建熙 | Controllable drug sustained release biological ceramic pill case and preparation technology and application thereof |
| CN106691598A (en) * | 2017-02-06 | 2017-05-24 | 浙江荣诚医疗科技有限公司 | Gold mark with coating and coating location device |
| CN107311654A (en) * | 2017-06-29 | 2017-11-03 | 王青山 | A kind of preparation method for aoxidizing zirconium base nanometer hydroxyapatite function-graded material |
| CN107307926A (en) * | 2017-08-11 | 2017-11-03 | 上海交通大学医学院附属第九人民医院 | A kind of porous beta tricalcium phosphate drug sustained release system and preparation method thereof |
| WO2018032664A1 (en) * | 2016-08-19 | 2018-02-22 | 北京派尔特医疗科技股份有限公司 | Titanium clip with drug-loading feature, drug-loaded titanium clip, and manufacturing method thereof |
| CN107822752A (en) * | 2017-10-25 | 2018-03-23 | 中国人民解放军总医院 | Bracket for eluting medicament and preparation method thereof |
| CN107822740A (en) * | 2017-10-25 | 2018-03-23 | 中国人民解放军总医院 | Artery medicine elution bracket of biological absorbable material and preparation method thereof |
| CN108793845A (en) * | 2018-07-05 | 2018-11-13 | 叶露穗 | A kind of calcium phosphate bioactive ceramics and preparation method thereof |
| CN114557364A (en) * | 2022-02-21 | 2022-05-31 | 广西环保产业发展研究院有限公司 | Chlorine dioxide slow-release air freshener |
| CN115040698A (en) * | 2021-08-05 | 2022-09-13 | 苏州大学 | Preparation method of maxillo-mandibular implant with medicine storage function |
| CN115432994A (en) * | 2022-11-09 | 2022-12-06 | 新明珠集团股份有限公司 | Fragrance slow-release ceramic plate with multistage pore diameter structure |
-
2008
- 2008-12-30 CN CNA2008102051093A patent/CN101461943A/en active Pending
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101962298B (en) * | 2010-04-20 | 2012-10-03 | 南京理工大学 | Method for preparing light nano porous ceramics |
| CN101962298A (en) * | 2010-04-20 | 2011-02-02 | 无锡南理工科技发展有限公司 | Method for preparing light nano porous ceramics |
| CN104586818A (en) * | 2013-11-01 | 2015-05-06 | 北京中卫神农慢性病医学研究院有限公司 | Micro-porous capsicine sustained-release apparatus |
| CN105194727A (en) * | 2014-06-04 | 2015-12-30 | 卢建熙 | Controllable drug sustained release biological ceramic pill case and preparation technology and application thereof |
| US10286117B2 (en) | 2016-08-19 | 2019-05-14 | B.J. Zh. F. Panther Medical Equipment Co. Ltd. | Titanium nail capable of loading drug and drug-loaded titanium nail and preparing method of the same |
| WO2018032664A1 (en) * | 2016-08-19 | 2018-02-22 | 北京派尔特医疗科技股份有限公司 | Titanium clip with drug-loading feature, drug-loaded titanium clip, and manufacturing method thereof |
| CN106691598A (en) * | 2017-02-06 | 2017-05-24 | 浙江荣诚医疗科技有限公司 | Gold mark with coating and coating location device |
| CN107311654A (en) * | 2017-06-29 | 2017-11-03 | 王青山 | A kind of preparation method for aoxidizing zirconium base nanometer hydroxyapatite function-graded material |
| CN107307926A (en) * | 2017-08-11 | 2017-11-03 | 上海交通大学医学院附属第九人民医院 | A kind of porous beta tricalcium phosphate drug sustained release system and preparation method thereof |
| CN107307926B (en) * | 2017-08-11 | 2024-03-19 | 上海交通大学医学院附属第九人民医院 | Porous beta-tricalcium phosphate medicine slow-release system and preparation method thereof |
| CN107822752A (en) * | 2017-10-25 | 2018-03-23 | 中国人民解放军总医院 | Bracket for eluting medicament and preparation method thereof |
| CN107822740A (en) * | 2017-10-25 | 2018-03-23 | 中国人民解放军总医院 | Artery medicine elution bracket of biological absorbable material and preparation method thereof |
| CN108793845A (en) * | 2018-07-05 | 2018-11-13 | 叶露穗 | A kind of calcium phosphate bioactive ceramics and preparation method thereof |
| CN115040698A (en) * | 2021-08-05 | 2022-09-13 | 苏州大学 | Preparation method of maxillo-mandibular implant with medicine storage function |
| CN115040698B (en) * | 2021-08-05 | 2023-08-11 | 苏州大学 | Method for designing and preparing jawbone implant with medicine storage function |
| CN114557364A (en) * | 2022-02-21 | 2022-05-31 | 广西环保产业发展研究院有限公司 | Chlorine dioxide slow-release air freshener |
| CN114557364B (en) * | 2022-02-21 | 2023-06-27 | 广西环保产业发展研究院有限公司 | Chlorine dioxide slow-release air freshener |
| CN115432994A (en) * | 2022-11-09 | 2022-12-06 | 新明珠集团股份有限公司 | Fragrance slow-release ceramic plate with multistage pore diameter structure |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101461943A (en) | Micropore ceramics and method for sustained-release of medicament or biological preparation and use thereof | |
| Kolmas et al. | Synthetic hydroxyapatite in pharmaceutical applications | |
| Zhou et al. | Loading BMP-2 on nanostructured hydroxyapatite microspheres for rapid bone regeneration | |
| Manzano et al. | Revisiting bioceramics: Bone regenerative and local drug delivery systems | |
| JP4172883B2 (en) | Drug sustained release carrier and method for producing drug sustained release carrier | |
| US6689375B1 (en) | Resorbable bone implant material and method for producing the same | |
| Lopez-Heredia et al. | An injectable calcium phosphate cement for the local delivery of paclitaxel to bone | |
| Paris et al. | Tuning dual-drug release from composite scaffolds for bone regeneration | |
| ES2837425T3 (en) | Structured Mineral Bone Substitute Mold | |
| ES2342123T3 (en) | BIOREABSORBIBLE COMPOSITION OF CONTROLLED LIBERATION. | |
| Ślósarczyk et al. | The kinetics of pentoxifylline release from drug-loaded hydroxyapatite implants | |
| Kim et al. | In situ formation of biphasic calcium phosphates and their biological performance in vivo | |
| TWI651103B (en) | Multiphase bone graft replacement material | |
| US8399009B2 (en) | Bioceramic and biopolymer composite | |
| US20160346211A1 (en) | Bioerodible silicon-based delivery vehicles for delivery of therapeutic agents | |
| CN101905033B (en) | Medicament microcapsule composite calcium deficiency calcium phosphate bone cement and use, preparation method and application thereof | |
| CN107073172A (en) | Porous foam derived from extracellular matrix, porous foam ECM medical treatment devices and its application method and manufacture method | |
| JPH04164456A (en) | Hydroxyl-apatite porous living organism filler and its manufacture | |
| Lasserre et al. | Ceramic drug-delivery devices | |
| TWI327071B (en) | Composite bone graft substitute cement and articles produced therefrom | |
| JP4802317B2 (en) | Calcium phosphate ceramic bead assembly and method for constructing the same | |
| Szymura-Oleksiak et al. | The kinetics of pentoxifylline release in vivo from drug-loaded hydroxyapatite implants | |
| CN101007184A (en) | Ultra-high-molecular-weight-polyethylene and drug complexes artificial joint material and its preparation method, and artificial joint prepared therefrom | |
| CN105194727A (en) | Controllable drug sustained release biological ceramic pill case and preparation technology and application thereof | |
| CN109331222B (en) | Bone repair material capable of forming 3D porous scaffold in situ and preparation and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20090624 |