CN101451992A - Biochemical sensing system, measurement device, biochemical sensing test piece and method for manufacturing same - Google Patents
Biochemical sensing system, measurement device, biochemical sensing test piece and method for manufacturing same Download PDFInfo
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- CN101451992A CN101451992A CNA2007101962935A CN200710196293A CN101451992A CN 101451992 A CN101451992 A CN 101451992A CN A2007101962935 A CNA2007101962935 A CN A2007101962935A CN 200710196293 A CN200710196293 A CN 200710196293A CN 101451992 A CN101451992 A CN 101451992A
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- insulated substrate
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Abstract
The invention provides a biochemical sensing system, a measuring device, a biochemical sensing test block and a manufacturing method. The biochemical sensing system comprises the biochemical sensing test block and the measuring device. The biochemical sensing test block has an insulated base plate, an electrode group arranged on the insulated base plate and image codes arranged on one side of the insulated base plate. The image codes have N components, and at least one of the N components impenetrates the insulated base plate. The measuring device has a microprocessing unit and a connector, which is coupled to the image codes and the electrode group to receive the signals corresponding to the image code, and the microprocessing unit is coupled to the connector to receive the signals from the connector.
Description
Technical field
The present invention relates to a kind of biochemical sensing system, measuring equipment, biochemical sensing test piece and manufacture method thereof, particularly, about a kind of biochemical sensing system from normal moveout correction, measuring equipment, biochemical sensing test piece and manufacture method thereof of exempting password card demand.
Background technology
Along with the progress of medical science and the modern lifting day by day for the health care idea, fixed point is looked after detection (Point-of-Care; POCT) market universalness also also heightens.The self-checking product that the detection trend of this class is quick, cheap, volume is little and do not need the professional to operate, for example blood glucose meter, electronics ear thermometer and electronics are sphygmomanometers etc.And in this field, the use of biochemical sensing test piece has been a very skillful technology, wherein again to analyze being most widely used of blood sugar.
In the known biochemical sensing system, each batch biochemical sensing test piece has all been set unique variation parameter in process of production.Therefore, using measuring equipment to need come measuring equipment is proofreaied and correct before this batch biochemical sensing test piece is measured by password card (code card), such as No. the 5366609th, United States Patent (USP) and PCT patent WO00/33072 number announcement.Yet the burning of password card and preparation can increase manpower and manufacturing cost, and the user is often taken place forget and insert or wrong plug password card causes problems such as mistake on error recovery and the data interpretation or the loss of password card.
Use the inconvenience that is caused in order to improve the password card, United States Patent (USP) has disclosed a kind of bar code (bar code) of utilizing for No. 6814844 as the identification mode.Fig. 1 shows No. 6814844 disclosed known detection test piece 100 of United States Patent (USP), and it comprises the test piece conduction group 110 with a plurality of electrodes insulated from each other and is arranged at bar code 120 in the middle of the test piece conduction group group 110.Bar code 120 is formed at the bar code graphics on the substrate for utilizing the laser molten method (laser ablaion method) that disappears, in detail, utilize high energy pulse laser bombardment to be coated on the surface of the gold target material on the substrate, make gold target material surface flash evapn, and form bar code graphics.Yet, such as No. the 6814844th, United States Patent (USP) announcement, the identification mode of bar code 120 is all the detection system of optical profile type, for example uses CCD or LED as detecting.Moreover the repeatability of this kind identification bar code 120 and accuracy not only can cause technologic restriction also may increase manufacturing cost in the target material surface material.
Therefore, being necessary to provide a kind of exempts the correction of password card and can keep process yield and the biochemical sensing system of detection accuracy rate.
Summary of the invention
In view of the existing problem of prior art, the invention provides a kind of use of exempting the password card, reduce misoperation and can reduce the not biochemical sensing system from normal moveout correction of yield rate of technology.
According to an aspect of the present invention, provide a kind of biochemical sensing system, it comprises biochemical sensing test piece and measuring equipment.The figure sign indicating number that biochemical sensing test piece has insulated substrate, is arranged at the electrode group on the insulated substrate and is arranged at a side of insulated substrate.Figure sign indicating number has N and constitutes the unit, and runs through one of at least insulated substrate in N formation unit.Be meant positive integer in this word " N " of noting this paper.Measuring equipment has microprocessing unit and connector, and wherein connector is in order to being coupled to figure sign indicating number and electrode group receiving the signal of corresponding diagram sign indicating number, and microprocessing unit is coupled to connector to receive the signal from connector.
According to a further aspect in the invention, provide a kind of measuring equipment.This measuring equipment, use in order to the collocation biochemical sensing test piece, the biochemical sensing test piece figure sign indicating number that has insulated substrate, be arranged at the electrode group on the insulated substrate and be arranged at a side of insulated substrate wherein, the figure sign indicating number has N and constitutes the unit, and N constitutes and to run through one of at least insulated substrate in the unit, measuring equipment comprises connector, in order to extremely figure yard of electrical couplings, to receive the signal that runs through the formation unit of insulated substrate in the corresponding diagram sign indicating number; And microprocessing unit, be coupled to connector to receive signal from connector.
In accordance with a further aspect of the present invention, provide a kind of biochemical sensing test piece, the figure sign indicating number that it comprises insulated substrate, is arranged at the electrode group on the insulated substrate and is arranged at a side of insulated substrate.Figure sign indicating number has N and constitutes the unit, and runs through one of at least insulated substrate in N formation unit.Constitute the unit and whether run through insulated substrate by controlling each N respectively, capable of being combinedly go out a plurality of different identification codes.
A kind of manufacture method of biochemical sensing test piece is provided according to another aspect of the invention.The method comprises following steps: insulated substrate is provided; Form conductive layer on insulated substrate; Provide the insulating mat high level on conductive layer, wherein the high-rise part that exposes conductive layer of insulating mat has the reaction zone of openend with formation; Be provided with and be placed on the insulating mat high level, wherein loam cake covers reaction zone at least; And carry out and to cut or punch press technology, to produce a plurality of biochemical sensing test pieces that have the figure sign indicating number of having set respectively, the figure sign indicating number of wherein having set partly runs through insulated substrate.
Other aspects of the present invention, part will be stated in follow-up explanation, and part can be learnt in illustrating easily, or can be learnt by enforcement of the present invention.Each side of the present invention can be utilized specifically noted element and combination in the accompanying Claim and understand and reach.Need to understand, aforesaid general remark and following detailed description are all only made usefulness for example, are not in order to restriction the present invention.
Description of drawings
Fig. 1 illustrates a known biochemical sensing test piece;
Fig. 2 illustrates the biochemical sensing test piece of one embodiment of the invention;
Fig. 3 illustrates the STRUCTURE DECOMPOSITION figure of the biochemical sensing test piece of Fig. 2;
Fig. 4 and Fig. 5 are the biochemical sensing test piece according to different embodiments of the invention illustrated;
Fig. 6 is the block schematic diagram according to the biochemical sensing system that one embodiment of the invention illustrated; And
Fig. 7 is the manufacture method process flow diagram of biochemical sensing test piece according to an embodiment of the invention.
Description of reference numerals
100 known detection test piece 110 test piece conduction groups
120 bar codes, 200 biochemical sensing test pieces
210 insulated substrates, 220 conductive layers
221 electrode groups, 222 working electrodes
224 reference electrodes, 226 sensing electrodes
228 figure sign indicating numbers, 230 insulating mat high levels
235 grooves, 240 responding layers
250 loam cakes, 255 air holes
400 biochemical sensing test pieces, 410 insulated substrates
422 working electrodes, 424 reference electrodes
426 sensing electrodes, 428 figure sign indicating numbers
428a, 428b, 428c, 428d, 428e, 428f constitute the unit
500 biochemical sensing test pieces, 510 insulated substrates
522 working electrodes, 524 reference electrodes
526 sensing electrodes, 528 figure sign indicating numbers
528a, 528b, 528c, 528d, 528e, 528f constitute the unit
600 biochemical sensing systems, 610 biochemical sensing test pieces
622 working electrodes, 624 reference electrodes
626 sensing electrodes, 628 figure sign indicating numbers
630 measuring equipments, 640 connectors
650 microprocessing units, 655 numerical datas
660 power supplys, 670 displays
Embodiment
The present invention discloses a kind of biochemical sensing system, measuring equipment, biochemical sensing test piece and the method for making thereof need not utilize the password card to proofread and correct, its can exempt the password clipping technique, easy to operate, prevent the possibility forgetting errors such as inserting password card or wrong plug password card and can reduce error generation in the manufacture process.In order to make narration of the present invention more detailed and complete, can and cooperate the graphic of Fig. 2 to Fig. 7, wherein similar elements symbology similar elements with reference to following description.Device, element and program step described in right following examples in order to explanation the present invention, is not in order to limit the scope of the invention only.
Fig. 2 illustrates the biochemical sensing test piece 200 of one embodiment of the invention, and Fig. 3 then illustrates the STRUCTURE DECOMPOSITION figure of biochemical sensing test piece 200.Biochemical sensing test piece 200 of the present invention comprises insulated substrate 210, conductive layer 220, insulating mat high level 230, reaches loam cake 250.Conductive layer 220 comprises electrode group 221 and figure sign indicating number 228, and wherein figure sign indicating number 228 comprises the part that runs through insulated substrate 210.Should also be formed by understanding figure sign indicating number 228 by conductive materials.In one embodiment, electrode group 221 comprises working electrode 222, reference electrode 224, and the sensing electrode 226 of mutually insulated.
The material of conductive layer 220 can be any conductive materials, for example carbon paste, gold and silver glue, copper glue, carbon silver epoxy glue or its analog and combination etc.In one embodiment, conductive layer 220 is by the conductive silver glue-line and place the conductive carbon bisque on the conductive silver glue-line to be formed.In this embodiment, sensing electrode 226 is arranged between working electrode 222 and the reference electrode 224, in order to sensing biochemical sensing test piece 200 and measuring equipment (as Fig. 6 620) between electric connection.After biochemical sensing test piece 200 is inserted measuring equipment, sensing electrode 226 will and measuring equipment between form the loop, and start measuring equipment.In fact, as long as each electrode group putting in order in reaction zone as above-mentioned, and it is insulated from each other promptly enough between each electrode, the present invention is restraint of labour electrode 222, reference electrode 224, and the arrangement of sensing electrode 226 not, also do not limit the quantity of electrode, can be according to required other electrodes that increases of practical application.
Insulating mat high level 230 places on the conductive layer 220, and comprises the groove 235 of a part that exposes conductive layer 220.As long as it is promptly enough that groove 235 can expose the working electrode 222 and the reference electrode 224 partly of part, the present invention is the shape of confinement groove 235 not.In addition, insulating mat high level 230 also exposes another part (indicate) of conductive layer 220 so that conductive layer 220 can with measuring equipment (as Fig. 6 620) be electrically connected.The material of insulating mat high level 230 can be including but not limited to PVC insulating tape, PET insulating tape, heated drying type insullac or ultraviolet curing type insullac.
Biochemical sensing test piece 200 of the present invention also comprises the responding layer 240 that places groove 235, it has the ability of selectivity identification biomaterial or signal, wherein the material of responding layer 240 is different and different with sample, for example can be oxidoreducing enzyme, in order to produce chemical reaction with sample.Generally speaking, responding layer 240 working electrode 222 of cover part at least.
Fig. 4 and Fig. 5 are the biochemical sensing test piece 400 and 500 according to different embodiments of the invention illustrated.Biochemical sensing test piece 400 comprises working electrode 422, reference electrode 424, sensing electrode 426, and the figure sign indicating number 428 of insulated substrate 410 and mutually insulated, and wherein figure sign indicating number 428 comprises six and constitutes unit 428a, 428b, 428c, 428d, 428e, and 428f.In this embodiment, constituting unit 428b is the groove that runs through insulated substrate 410.With reference to figure 5, biochemical sensing test piece 500 comprises working electrode 522, reference electrode 524, sensing electrode 526, and the figure sign indicating number 528 of insulated substrate 510 and mutually insulated, and wherein figure sign indicating number 528 comprises six and constitutes unit 528a, 528b, 528c, 528d, 528e, and 528f.In the embodiment shown in fig. 5, constituting unit 528c and 528e is the groove that runs through insulated substrate.Therefore, when biochemical sensing test piece 400 or 500 is inserted measuring equipment, groove part in the figure sign indicating number (as constituting unit 428b, 528c or 528e) can't form with measuring equipment and electrically connect, and make measuring equipment be distinguished biochemical sensing test piece 400 and 500 therefrom.
Have six figure sign indicating numbers that constitute the unit though Fig. 4 and Fig. 5 have shown, the present invention does not limit the quantity that constitutes the unit.Also should be appreciated that the quantity and the position that constitute the groove in the unit can be set up on their own according to practical application by the deviser, it is capable of being combined to go out a plurality of different identification codes.For instance, when figure sign indicating number has N formation unit, go out 2N-1 identification code with capable of being combined.In other embodiments, constitute unit 428b, 528c or 528e and can be the hole that runs through insulated substrate, but not groove.The present invention also not the shape of confinement groove or hole with the size.
Fig. 6 is the block schematic diagram according to the biochemical sensing system 600 that one embodiment of the invention illustrated, and it comprises biochemical sensing test piece 610 and measuring equipment 630.Biochemical sensing test piece 610 comprises working electrode 622, reference electrode 624, sensing electrode 626, reaches figure sign indicating number 628, and wherein figure sign indicating number 628 comprises at least one groove, as previously mentioned.Measuring equipment 630 comprises connector 640 and is coupled to the microprocessing unit 650 of connector 640, microprocessing unit 650 built-in numerical datas 655 wherein, and it can for example be correction parameter, detecting pattern or other information etc.Working electrode 622, reference electrode 624, sensing electrode 626, and figure sign indicating number 628 sees through and connector 640 between join and be electrical connected with measuring equipment 630.
When biochemical sensing test piece 610 is connected with connector 640, will form the loop between sensing electrode 626 and the connector 640, and make microprocessing unit 650 start measuring equipment 630.In addition, because the groove part of figure sign indicating number 628 can't form with connector 640 and electrically connect, therefore will produce the chopping signal of corresponding this groove part to microprocessing unit 650, microprocessing unit 650 will carry out identification according to this signal, and select the parameter of corresponding this signal or pattern to carry out in data 655.Measuring equipment 630 also comprises in order to the display 670 that shows various measurements, and the power supply 660 in order to required power supply to be provided.In another embodiment, display 670 and power supply 660 can be external device, and are not contained in the measuring equipment 630.
Fig. 7 is the manufacture method process flow diagram of biochemical sensing test piece according to an embodiment of the invention.At first, in step S700, provide insulated substrate.Then, in step S710, the coating conductive materials on insulated substrate and form conductive layer, the conductive layer figure sign indicating number that comprises a plurality of electrodes of mutually insulated and do not set wherein.The so-called figure sign indicating number of not setting is meant the figure sign indicating number of the formation unit that does not comprise groove or hole, and meaning does not promptly comprise formation unit 428b shown in Figure 4 or 528c shown in Figure 5 and the figure sign indicating number of 528e.For example, the figure sign indicating number of not setting in some embodiment can comprise the formation unit of non-groove or hole, as Fig. 4 and shown in constitute unit 428a, 428c, 428d, 428e, and 428f, or formation unit 528a as shown in Figure 5,528b, 528d, and 528f.So in another embodiment, the figure sign indicating number of not setting can not have to appoint to close the formation unit yet.Then, in step S720, provide the insulating mat high level on conductive layer, wherein the insulating mat high level exposes the part of conductive layer and forms the reaction zone with openend.Then, in step S730, add responding layer in reaction zone, it has the ability of selectivity identification biomaterial or signal.Then, in step S740, be provided with and be placed on the insulating mat high level, and this loam cake covers reaction zone at least.At last, in step S750, carry out cutting or punch press technology, to produce a plurality of biochemical sensing test pieces that have the figure sign indicating number of having set respectively, the figure sign indicating number of wherein having set partly runs through insulated substrate.In detail, the figure sign indicating number of having set comprises the formation unit of groove or hole, and meaning is that the formation unit (formation unit 428b as shown in Figure 4 or 528c and 528e shown in Figure 5) of groove or hole is to form in step S750.
Figure sign indicating number of the present invention be for identification with specify in the measuring equipment built-in data, wherein have correction parameter, detecting pattern or other information of many groups in the measuring equipment corresponding to the last figure code combination of test piece number.Disclosed biochemical sensing system not only reaches purpose that need not the password card and has reduced the manufacturing cost of test piece.
The above is the preferred embodiments of the present invention only, is not in order to limit claim of the present invention; All other do not break away from the equivalence of being finished under the disclosed spirit and changes or modification, all should be included in the following claim.
Claims (18)
1. biochemical sensing system comprises:
Biochemical sensing test piece, the figure sign indicating number that has insulated substrate, is arranged at the electrode group on this insulated substrate and is arranged at a side of this insulated substrate, wherein this figure sign indicating number has N and constitutes the unit, and one of at least runs through this insulated substrate in this N formation unit, and wherein N is a positive integer; And
Measuring equipment has microprocessing unit and connector, and wherein this connector is in order to being coupled to this figure sign indicating number and this electrode group receiving should scheming the signal of sign indicating number, and this microprocessing unit is coupled to this connector to receive this signal from this connector.
2. biochemical sensing system as claimed in claim 1, the wherein built-in many group correction parameters of this microprocessing unit, and this processing unit select wherein one group of correction parameter that this biochemical sensing system is proofreaied and correct according to this signal that is received.
3. biochemical sensing system as claimed in claim 1, the wherein built-in a plurality of patterns of this microprocessing unit, and this processing unit are selected wherein pattern execution according to this signal that is received.
4. biochemical sensing system as claimed in claim 1, wherein this electrode group comprises working electrode, reference electrode, and the sensing electrode of mutually insulated, and wherein this sensing electrode in order to the electric connection between this biochemical sensing test piece of sensing and this measuring equipment.
5. measuring equipment, use in order to the collocation biochemical sensing test piece, this biochemical sensing test piece figure sign indicating number of having insulated substrate, being arranged at the electrode group on this insulated substrate and being arranged at a side of this insulated substrate wherein, this figure sign indicating number has N and constitutes the unit, and this N constitutes and to run through one of at least this insulated substrate in the unit, wherein N is a positive integer, and this measuring equipment comprises:
Connector, in order to electrical couplings to this figure sign indicating number, to receive signal to this formation unit that should scheme to run through in the sign indicating number this insulated substrate; And
Microprocessing unit is coupled to this connector to receive this signal from this connector.
6. biochemical sensing test piece comprises:
Insulated substrate;
The electrode group is arranged on this insulated substrate; And
Scheme sign indicating number, be arranged at a side of this insulated substrate;
Wherein this figure sign indicating number has N and constitutes the unit, and wherein N is a positive integer, runs through the identification code of this biochemical sensing test piece of determining positions of the formation unit of this insulated substrate by at least one of this N formation unit.
7. biochemical sensing test piece as claimed in claim 6, wherein this N constitutes that the unit is capable of being combined to go out 2N-1 identification code.
8. biochemical sensing test piece as claimed in claim 6, this formation unit that wherein runs through this insulated substrate is a hole.
9. biochemical sensing test piece as claimed in claim 6, this formation unit that wherein runs through this insulated substrate is a groove.
10. biochemical sensing test piece as claimed in claim 6 also comprises:
The insulating mat high level covers the part of this electrode group, is wherein formed the reaction zone with openend by the part of high-rise this electrode group that covers of this insulating mat; And
Loam cake places on this insulating mat high level and covers this reaction zone, and this loam cake has air hole that should reaction zone.
11. biochemical sensing test piece as claimed in claim 10 also comprises responding layer, places this reaction zone, wherein this responding layer comprises oxidoreducing enzyme.
12. biochemical sensing test piece as claimed in claim 6, wherein this electrode group comprises working electrode, reference electrode, and the sensing electrode of mutually insulated.
13. biochemical sensing test piece as claimed in claim 11, wherein this responding layer covers this working electrode at least.
14. biochemical sensing test piece as claimed in claim 6, the wherein following group that is formed of the optional freedom of material of this electrode group and this figure sign indicating number: carbon paste, elargol, copper glue, gold and silver epoxy glue, carbon silver epoxy glue, and composition thereof.
15. the manufacture method of a biochemical sensing test piece comprises following steps:
Insulated substrate is provided;
Form conductive layer on this insulated substrate;
Provide the insulating mat high level on this conductive layer, wherein the high-rise part that exposes this conductive layer of this insulating mat has the reaction zone of openend with formation;
Be provided with and be placed on this insulating mat high level, this loam cake covers this reaction zone at least; And
Execution cuts or punch press technology, has the biochemical sensing test piece of figure sign indicating number with generation, and wherein this figure sign indicating number has the formation unit that at least one runs through this insulated substrate.
16. manufacture method as claimed in claim 15, the step that wherein forms this conductive layer also comprises following steps:
Provide conductive materials on this insulated substrate;
This conductive materials of etching, with reference electrode, working electrode, the sensing electrode that forms mutually insulated, the formation unit that reaches this figure sign indicating number, this formation unit does not run through this insulated substrate.
17. manufacture method as claimed in claim 15, wherein this formation unit that runs through this insulated substrate be carry out this cut or during this punch press technology institute form.
18. manufacture method as claimed in claim 15, wherein this formation unit that runs through this insulated substrate is groove or hole.
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CNA2007101962935A CN101451992A (en) | 2007-12-07 | 2007-12-07 | Biochemical sensing system, measurement device, biochemical sensing test piece and method for manufacturing same |
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CNA2007101962935A CN101451992A (en) | 2007-12-07 | 2007-12-07 | Biochemical sensing system, measurement device, biochemical sensing test piece and method for manufacturing same |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102954989A (en) * | 2012-11-30 | 2013-03-06 | 北京宏元兴邦科技有限责任公司 | Electrochemical sensing strip |
CN108414594A (en) * | 2017-02-10 | 2018-08-17 | 琦芯科技股份有限公司 | Biological sensing test piece made of non-etching solvent and its making method |
CN109085329A (en) * | 2018-07-23 | 2018-12-25 | 青岛厚美德生物科技有限公司 | One kind is exempted to adjust code bio-sensing test paper and its exempts to adjust code identifying processing method |
-
2007
- 2007-12-07 CN CNA2007101962935A patent/CN101451992A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102954989A (en) * | 2012-11-30 | 2013-03-06 | 北京宏元兴邦科技有限责任公司 | Electrochemical sensing strip |
CN108414594A (en) * | 2017-02-10 | 2018-08-17 | 琦芯科技股份有限公司 | Biological sensing test piece made of non-etching solvent and its making method |
CN109085329A (en) * | 2018-07-23 | 2018-12-25 | 青岛厚美德生物科技有限公司 | One kind is exempted to adjust code bio-sensing test paper and its exempts to adjust code identifying processing method |
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Application publication date: 20090610 |