CN101450232B - Double-channel hollow fiber film type artificial lung and manufacture method thereof - Google Patents
Double-channel hollow fiber film type artificial lung and manufacture method thereof Download PDFInfo
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- CN101450232B CN101450232B CN2008102206959A CN200810220695A CN101450232B CN 101450232 B CN101450232 B CN 101450232B CN 2008102206959 A CN2008102206959 A CN 2008102206959A CN 200810220695 A CN200810220695 A CN 200810220695A CN 101450232 B CN101450232 B CN 101450232B
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Abstract
The invention provides a dual-channel hollow fibre film type artificial lung and a method thereof. The artificial lung includes a case and an inner-placed hollow fibre bundle consisted of hollow fibre, the case is made of gradient earthenware pipe and inner wall of the case is coated with ionomer film; the hollow fibre outside surface is coated with liquid crystal/silicon rubber crosslinking film. The invention also provides a method for manufacturing the artificial lung which mainly includes a coating technics of the hollow fibre and gradient earthenware pipe. The invention firstly disclosesthat O2 and CO2 have a dual-channel type artificial lung respectively, compared with the artificial lung with single channel, oxygen gas transmitting rate is larger and pressure fall is lower, working life is more longer and better oxygenation effect can be obtained.
Description
Technical field
The present invention relates to doughnut membrane type artificial lung, be specifically related to a kind of O
2And CO
2Turnover have the dual pathways doughnut membrane type artificial lung and the manufacture method thereof of passage separately respectively.
Background technology
Artificial lung has O in the blood of adjusting
2And CO
2The function of content, its major function are to realize O by the film of doughnut surface applied
2Picked-up and CO
2Discharge.External membrane artificial lungs still exists blood-transmitted efficient deficiency as current clinical practice and business-like oxygenator, and blood penetration causes the gas exchange amount to descend problems such as shortening service time.And the oxygenator of domestic clinical practice, the membrane module of its use almost all relies on import.
Hollow-fibre membrane is that doughnut membrane type artificial lung carries out blood and O
2, CO
2The support body material of exchange is a kind of porous membrane of being made by high molecular synthetic material.Membranous wall must apply a kind of polymeric membrane for separation of densification, and this is the core material of artificial lung.Usually, logical oxygen is walked blood in the doughnut between the fiber.Oxygen exchanges CO with the molecularity infiltration by the dense film of coating and the hemoglobin in the blood
2Infiltration is discharged after entering doughnut by film from blood.This oxygenator also is called single channel doughnut membrane type artificial lung (as shown in Figure 1 by us, taking in the hollow fiber bundle that doughnut 2 forms by polyurethane outer 1 constitutes, the doughnut outer surface is coated with silicone rubber membrane, and the place, two ends is provided with seal 3 and 4, and O is set respectively on the shell
2Import 5, O
2And CO
2Outlet 6, the import 7 of blood and the outlet 8 of blood).This exchanged form has improved blood absorption O
2Ability, reduced the degeneration of serum albumin.But exist blood plasma easily to stop up problems such as coat film and the easy deposition of blood constituent at present, and O
2And CO
2Infiltration all must be easy to hinder O by identical film
2And CO
2Infiltration, thereby shortened service time of artificial lung.Improve the structure of artificial lung, improve blood and O
2And CO
2Exchange efficiency, improve the gas permeation rate of coat film and anticoagulation, contamination resistance, extend working time, be valid approach in the current artificial lung research.Therefore, improve the O that industrial single channel doughnut membrane type artificial lung is adopted
2And CO
2The infiltration defective that all must exist by identical film, explore a kind of new O
2And CO
2Penetration mode be the researcher problem demanding prompt solution.
Summary of the invention
The objective of the invention is to overcome the shortcoming of existing single channel doughnut membrane type artificial lung, a kind of dual pathways doughnut membrane type artificial lung is provided, similarly dual pathways doughnut membrane type artificial lung is not seen in worldwide any bibliographical information up to now.
Another object of the present invention provides the manufacture method of above-mentioned dual pathways doughnut membrane type artificial lung.
The objective of the invention is to realize by following technical solution: a kind of dual pathways doughnut membrane type artificial lung, comprise housing and the built-in hollow fiber bundle of forming by doughnut, wherein, the material of described housing is a graded ceramic tube, and its coated inner wall is from ionpolymeric film; Outer surface coated with liquid crystal/silicone rubber crosslinking the film of described doughnut.
The outer wall preferred coated inverse osmosis membrane coat of described graded ceramic tube.
The manufacture method of above-mentioned dual pathways doughnut membrane type artificial lung comprises following concrete steps:
(1) outer surface of hollow-fibre membrane coating
With the vinyl molar content is the silicone rubber of 2-10%, with oxolane or petroleum ether dissolution, forms homogeneous solution, adds the catalyst platinum acid chloride solution again, and stirring is mixed with component one, and the mass fraction of silicone rubber is 5-7.5% in the component one; With oxolane or petroleum ether dissolution olefin(e) acid cholesterol ester liquid crystal, form homogeneous solution, adding containing hydrogen silicone oil cross-linking agent stirs and is mixed with component two, and the mass fraction of olefin(e) acid cholesterol ester liquid crystal is 5-7.5% in the component two; After doughnut successively soaked component one and component two solution,, liquid crystal/silicone rubber crosslinking is solidified by heating; Apply repeatedly, promptly obtain the doughnut of uniform liquid crystal/silicone rubber crosslinking film on the surface applied;
(2) the graded ceramics inside pipe wall applies from ionpolymeric film
With graded ceramic tube, clean with the ultrasonic concussion of distilled water, then with the abundant vacuum drying of cleaned graded ceramic tube;
With mass concentration is that 0.5-3% pours in the earthenware from aggressiveness solution, and quick slant is placed graded ceramic tube makes the liquid level of solution of pouring into just in time equal with the top bead of graded ceramic tube; Rotate graded ceramic tube and pour out the residue residual liquid after one week; Graded ceramic tube is placed in air, and solution is no longer till the wire drawing, the abundant vacuum drying film forming of graded ceramic tube in waiting to manage;
(3) assembling of artificial lung
With (1) gained doughnut assembling bunchy, load to applying in the graded ceramic tube of ionpolymeric film, use epoxy resin to carry out end-blocking, make described dual pathways doughnut membrane type artificial lung.
In the outer surface coated technique of the described hollow-fibre membrane of step (1), for reaching better coating effect, described silicone rubber is vinylsiloxane rubber, and the molar content of vinyl is preferably 5%; In the described component one, the mass concentration of silicone rubber is preferably 5.0%; In the described component two, the mass concentration of olefin(e) acid cholesterol ester liquid crystal is preferably 5.0%; In the described component one, the chloroplatinic acid mass concentration is preferred 0.02～0.05%, and more preferably 0.02%; In the described component two, described containing hydrogen silicone oil cross-linking agent mass concentration is preferred 0.04%～0.06%, and more preferably 0.05%.
In the coated inner wall technology of the described graded ceramic tube of step (2), for reaching better coating effect, described mass concentration from aggressiveness solution is preferably 1%, describedly preferably contains cobalt from aggressiveness from aggressiveness.
The action principle of above-mentioned dual pathways doughnut membrane type artificial lung is: the flow process of picked-up oxygen, discharge carbon dioxide adopts oxygen to enter in the doughnut from the porch, see through liquid crystal/silicone rubber crosslinking film, enter behind the blood and the hemoglobin oxygenate, simultaneously, carbon dioxide in the blood sees through from ionpolymeric film, excretes by the earthenware sheathing material.
Compared to existing technology, the present invention has following beneficial effect: the present invention has overcome the defective that present industrial single channel doughnut membrane type artificial lung exists, O
2And CO
2Having separately respectively, the dual pathways doughnut membrane type artificial lung of passage will provide technology to use for reference for the design of membrane artificial lungs.Compare with single channel doughnut membrane type artificial lung, the oxygen transmission rate of dual pathways membrane artificial lungs is bigger, and pressure falls lower, and longer service life has higher oxygenate effect.
Description of drawings
Fig. 1 is the single channel doughnut membrane type artificial lung sketch map of industrial employing;
Fig. 2 is a dual pathways doughnut membrane type artificial lung sketch map of the present invention;
Fig. 3 is the testing in vitro flow chart of membrane artificial lungs assembly;
Fig. 4 is the influence figure of the flow velocity of normal saline and deionized water to oxygen transmission rate;
Fig. 5 is that the flow velocity of normal saline and deionized water influences figure to what pressure fell;
Fig. 6 is the influence figure of testing time to oxygen transmission rate;
Fig. 7 is the testing time influences figure to what pressure fell.
The specific embodiment
Below in conjunction with embodiment and accompanying drawing, the present invention is described in further detail, but the mode of practicing of the present invention is not limited thereto.
The invention will be further described below in conjunction with accompanying drawing.Dual pathways doughnut membrane type artificial lung of the present invention is to take in the hollow fiber bundle that doughnut 10 is formed with graded ceramics pipe shell 9, and O is set on the shell
2Import 11, O
2Outlet 12, the import 13 of blood and the outlet 14 of blood, and at the two ends of artificial lung are promptly near O
2Import 11, O
2Outlet 12 places epoxy sealing end 15 and 16 are set.The coated inner wall of graded ceramics pipe shell 9 is from ionpolymeric film, and outer wall optionally applies the inverse osmosis coating.Outer surface coated with liquid crystal/silicone rubber crosslinking the film of doughnut 10.The flow process of dual pathways doughnut membrane type artificial lung picked-up oxygen, discharge carbon dioxide adopts oxygen to enter in the doughnut from the porch, see through liquid crystal/silicone rubber crosslinking film, enter behind the blood and the hemoglobin oxygenate, simultaneously, carbon dioxide in the blood sees through from ionpolymeric film, excretes by the earthenware sheathing material.Adopt in the doughnut and walk oxygen, doughnut outer wall and earthenware inwall are walked the mode of water, replace blood with normal saline and deionized water respectively, measure the external performance of dual pathways doughnut membrane type artificial lung.
Embodiment 1
1, the surface applied of hollow-fibre membrane
Select the two component coated techniques of doughnut for use: with the vinyl molar content is 5% silicone rubber, with the oxolane dissolving, adds the catalyst platinum acid chloride solution, and stirring is mixed with component one, and the mass concentration of silicone rubber is 5% in the component one; With oxolane dissolving olefin(e) acid cholesterol ester liquid crystal, adding containing hydrogen silicone oil cross-linking agent stirs and is mixed with component two, and olefin(e) acid cholesterol ester liquid crystal mass concentration is 5% in the component two.After doughnut successively soaked component one and component two solution, behind heater, silicone rubber crosslinking is solidified.Coating repeatedly, can be on the doughnut surface applied liquid crystal/silicone rubber crosslinking film uniformly.
2, the surface applied from ionpolymeric film of earthenware inwall
Graded ceramic tube is placed ultrasonic oscillator, cleaned 24 hours with the distilled water concussion, to remove the dust and the granule of the inner remained on surface of earthenware, make after the ionpolymeric film molding, to have good smoothness, also help film simultaneously and stick molding at the earthenware inwall.Cleaned earthenware was placed 35 ℃ of vacuum desiccator intensive dryings 2 days.
With pouring in the earthenware from aggressiveness solution (mass percent is 1%) of configuring, quick slant is placed earthenware makes the liquid level of solution of pouring into just in time equal with the top bead of earthenware.Rotate earthenware with the speed of v=10r/min and pour out the residue residual liquid after one week.Earthenware is placed a period of time in air, and solution no longer till the wire drawing, places earthenware 35 ℃ vacuum desiccator to preserve the intensive drying film forming two days in waiting to manage.After get wherein the part pipe and pour into once more from aggressiveness solution and rotate all film forming.Under scanning electron microscope, observe and be about 5～10 μ m from the thickness of ionpolymeric film at the earthenware inwall.
3, the assembling of artificial lung
The doughnut of coated with liquid crystal/silicone rubber membrane is loaded to applying in the graded ceramic tube of ionpolymeric film, used epoxy resin to carry out end-blocking, by leak detection, mending course makes the dual pathways doughnut membrane type artificial lung assembly sketch map as Fig. 2.The relevant parameter of dual pathways doughnut membrane type artificial lung assembly is listed in table 1.
Table 1 dual pathways doughnut membrane type artificial lung assembly relevant parameter
1, the surface applied of hollow-fibre membrane
Select the two component coated techniques of doughnut for use: with the vinyl molar content is 2% silicone rubber, with the oxolane dissolving, adds the catalyst platinum acid chloride solution, and stirring is mixed with component one, and the mass concentration of silicone rubber is 6% in the component one; With petroleum ether dissolution olefin(e) acid cholesterol ester liquid crystal, adding containing hydrogen silicone oil cross-linking agent stirs and is mixed with component two, and olefin(e) acid cholesterol ester liquid crystal mass concentration is 6% in the component two.After doughnut successively soaked component one and component two solution, behind heater, silicone rubber crosslinking is solidified.Coating repeatedly, can be on the doughnut surface applied liquid crystal/silicone rubber crosslinking film uniformly.
2, the surface applied from ionpolymeric film of earthenware inwall
Graded ceramic tube is placed ultrasonic oscillator, cleaned 24 hours with the distilled water concussion, to remove the dust and the granule of the inner remained on surface of earthenware, make after the ionpolymeric film molding, to have good smoothness, also help film simultaneously and stick molding at the earthenware inwall.Cleaned earthenware was placed 35 ℃ of vacuum desiccator intensive dryings 2 days.
With pouring in the earthenware from aggressiveness solution (mass percent is 0.5%) of configuring, quick slant is placed earthenware makes the liquid level of solution of pouring into just in time equal with the top bead of earthenware.Rotate earthenware with the speed of v=10r/min and pour out the residue residual liquid after one week.Earthenware is placed a period of time in air, and solution no longer till the wire drawing, places earthenware 35 ℃ vacuum desiccator to preserve the intensive drying film forming two days in waiting to manage.After get wherein the part pipe and pour into once more from aggressiveness solution and rotate all film forming.Under scanning electron microscope, observe and be about 5～10 μ m from the thickness of ionpolymeric film at the earthenware inwall.
3, the assembling of artificial lung
The doughnut of coated with liquid crystal/silicone rubber membrane is loaded to applying in the graded ceramic tube of ionpolymeric film, used epoxy resin to carry out end-blocking, by leak detection, mending course makes the dual pathways doughnut membrane type artificial lung assembly sketch map as Fig. 2.The relevant parameter of dual pathways doughnut membrane type artificial lung assembly is listed in table 2.
Table 2 dual pathways doughnut membrane type artificial lung assembly relevant parameter
1, the surface applied of hollow-fibre membrane
Select the two component coated techniques of doughnut for use: with the vinyl molar content is 10% silicone rubber, with the oxolane dissolving, adds the catalyst platinum acid chloride solution, and stirring is mixed with component one, and the mass concentration of silicone rubber is 7.5% in the component one; Oxolane dissolving olefin(e) acid cholesterol ester liquid crystal, adding containing hydrogen silicone oil cross-linking agent stirs and is mixed with component two, and olefin(e) acid cholesterol ester liquid crystal mass concentration is 7.5% in the component two.After doughnut successively soaked component one and component two solution, behind heater, silicone rubber crosslinking is solidified.Coating repeatedly, can be on the doughnut surface applied liquid crystal/silicone rubber crosslinking film uniformly.
2, the surface applied from ionpolymeric film of earthenware inwall
Graded ceramic tube is placed ultrasonic oscillator, cleaned 32 hours with the distilled water concussion, to remove the dust and the granule of the inner remained on surface of earthenware, make after the ionpolymeric film molding, to have good smoothness, also help film simultaneously and stick molding at the earthenware inwall.Cleaned earthenware was placed 35 ℃ of vacuum desiccator intensive dryings 3 days.
With pouring in the earthenware from aggressiveness solution (mass percent is 3%) of configuring, quick slant is placed earthenware makes the liquid level of solution of pouring into just in time equal with the top bead of earthenware.Rotate earthenware with the speed of v=15r/min and pour out the residue residual liquid after one week.Earthenware is placed a period of time in air, and solution no longer till the wire drawing, places earthenware 35 ℃ vacuum desiccator to preserve the intensive drying film forming two days in waiting to manage.After get wherein the part pipe and pour into once more from aggressiveness solution and rotate all film forming.Under scanning electron microscope, observe and be about 5～10 μ m from the thickness of ionpolymeric film at the earthenware inwall.
3, the assembling of artificial lung
The doughnut of coated with liquid crystal/silicone rubber membrane is loaded to applying in the graded ceramic tube of ionpolymeric film, used epoxy resin to carry out end-blocking, by leak detection, mending course makes dual pathways doughnut membrane type artificial lung.The relevant parameter of dual pathways doughnut membrane type artificial lung is listed in table 3.
Table 3 dual pathways doughnut membrane type artificial lung relevant parameter
| (mm) |
Testing external performance
Dual pathways doughnut membrane type artificial lung with embodiment 1 assembling is an example below, and in its performance of testing in vitro, the performance of embodiment 2-3 gained dual pathways doughnut membrane type artificial lung and embodiment's 1 is similar.
Assembling laboratory tests flow process as shown in Figure 3 comprises liquid phase circulation canal and gas phase channel.Liquid channel uses the medical polyvinyl blood vessel to connect the blood inlet 13 of liquid storing bag 17, blood pump 18, constant temperature instrument 19, effusion meter 20 and artificial lung successively, and the blood outlet 14 of the artificial lung liquid that comes out is back to liquid storing bag 17.Piezometer 21 among the figure and oxygen analyser 22 and 23 are used to detect liquid phase pressure and the oxygen content that blood inlet 13 and blood export 14 places.Gas phase channel partly uses the O of oxygen source 24, effusion meter 25 and artificial lung that the General Purpose Rubber pipe connects successively
2Import 11, unreacted O
2O from artificial lung
2Artificial lung is got rid of in outlet 12.The concrete operations step is as follows:
1. according to assembling and testing device shown in Figure 3;
2. use dosing container to demarcate blood pump 18 flow velocitys;
3. use the Na of new preparation
2SO
3The distilled water of solution and uncovered long-time placement is demarcated oxygen analyser 22 and 23;
4. with CO
2And N
2After 1: 4 mixed, feed liquid storing bag 17 continuously in the bubbling mode and carry out 15min, and measure the dissolved oxygen value of water in the bag, reduce to (concentration of dissolved oxygen adopts the Shanghai thunder magnetic RSS-5100 of instrument plant type oxygen analyser to measure in the liquid phase) below the 1mg/L until the concentration of aqueous phase oxygen;
5. open oxygen, regulate desired flow;
6. open liquid storing bag 17 valves, open blood pump 18, make water fill whole loop.The folliculus device can be used for removing the foam that water may exist after the deoxidation; Exhaust apparatus is used for removing the oxygen of bloody path.Regulate the flow velocity of liquid phase and the flow velocity of oxygen, behind system stability, measure the oxygen dissolution amount of heavy-oxygen-enriched water once more, write down the pressure difference under this flow velocity simultaneously.
5. and 6. repeating step is measured the oxygen dissolution amount and the pressure difference of (50ml/min, 150ml/min, 250ml/min, 350ml/min, 450ml/min) under different oxygen gas flow rates and the liquid phase flow rate.
The mensuration that oxygen transmission rate and pressure fall
Oxygen transmission rate: the gas-liquid flow-rate ratio selected for use of experiment equals 3, and the flow velocity of water is respectively 50,150,250,350 and 450ml/min.By measuring the different oxygen dissolution amounts of WATER AS FLOW MEDIUM, can calculate the transfer rate of oxygen at the import and export of process doughnut membrane type artificial lung.
Pressure falls: measure the different pressure reduction of oxygenator import and export, be the pressure of fluid by oxygenator and fall.Can calculate the average transmission rate of oxygen to water, R according to mass balance
O-W(ml/min):
R
O-W＝Q
W(C
O-C
I)
Q in the formula
W---the flow rate of water, 1/min;
C
O, C
I---be respectively the dissolubility (ml/l) of oxygenator outlet and water inlet oxygen.
Embodiment 6
External performance
(1) oxygen transmission rate is to the artificial lung Effect on Performance
The flow velocity of normal saline and deionized water to the influence of dual pathways doughnut membrane type artificial lung oxygen transmission rate as shown in Figure 4.As seen from the figure, oxygen transmission rate increases and increases along with aqueous phase flow rate on the whole.For example, silicone rubber concentration is 5.0% in the doughnut coated film, and gas and fluid flow are 3 o'clock, and when normal saline and deionized water flow velocity were 50ml/min, oxygen transmission rate was respectively 31.0ml/ (minm
2) and 26.2ml/ (minm
2); And when normal saline and deionized water flow velocity increased to 450ml/min, oxygen transmission rate was respectively 71.6ml/ (minm
2) and 65.9ml/ (minm
2).
(2) pressure falls the artificial lung Effect on Performance
Fig. 5 is the influence that the flow velocity of normal saline and deionized water falls pressure.As can be seen from the figure, along with the flow velocity increase of normal saline and deionized water, pressure falls gradually to be increased.For example, silicone rubber concentration is 5.0% in the doughnut coated film, and gas and fluid flow are 3 o'clock, and when normal saline and deionized water flow velocity were 50ml/min, pressure fell and is respectively 15.4mmHg and 13.3mmHg; And when normal saline and deionized water flow velocity increased to 450ml/min, pressure fell and is respectively 29.1mmHg and 26.9mmHg.In addition, also as can be seen, pressure falls and is always maintained at below the 30mmHg, meets the basic demand of membrane artificial lungs from figure.
(3) testing time is to the artificial lung Effect on Performance
Fig. 6 and Fig. 7 are respectively the influence that the experiment test time falls oxygen transmission rate and pressure.As can be seen from the figure, no matter be in normal saline or deionized water, oxygen transmission rate and pressure fall all and descend along with the increase of experiment test time.In 2 day testing time, oxygen transmission rate and pressure fall slightly and reduce, but after surpassing 4 days, oxygen transmission rate and pressure are fallen trend and increased.
Compare with single channel doughnut membrane type artificial lung, the oxygen transmission rate of dual pathways membrane artificial lungs is bigger, and pressure falls lower, longer service life.Show liquid crystal/silicone rubber crosslinking film and help improving the oxygenate effect of membrane artificial lungs from ionpolymeric film.Can look forward to, dual pathways doughnut membrane type artificial lung will have excellent research prospect and using value.
The foregoing description is a preferred implementation of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other any do not deviate from change, the modification done under spirit of the present invention and the principle, substitutes, combination, simplify; all should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (7)
1. dual pathways doughnut membrane type artificial lung comprises housing and the built-in hollow fiber bundle of being made up of doughnut, and it is characterized in that: the material of described housing is a graded ceramic tube, and its coated inner wall is from ionpolymeric film; Outer surface coated with liquid crystal/silicone rubber crosslinking the film of described doughnut is provided with O on shell
2Import and export and the import and export of blood, thereby the oxygen of absorption is entered in the doughnut from the porch, see through liquid crystal/silicone rubber crosslinking film, enter behind the blood and the hemoglobin oxygenate, simultaneously, the carbon dioxide in the blood sees through from ionpolymeric film, excretes by the earthenware sheathing material.
2. dual pathways doughnut membrane type artificial lung according to claim 1 is characterized in that: the outer wall coating inverse osmosis membrane coat of described graded ceramic tube.
3. the manufacture method of claim 1 or 2 described dual pathways doughnut membrane type artificial lungs is characterized in that comprising following concrete steps:
(1) outer surface of hollow-fibre membrane coating
With the vinyl molar content is the silicone rubber of 2-10%, with oxolane or petroleum ether dissolution, forms homogeneous solution, adds the catalyst platinum acid chloride solution again, and stirring is mixed with component one, and the mass fraction of silicone rubber is 5-7.5% in the component one; With oxolane or petroleum ether dissolution olefin(e) acid cholesterol ester liquid crystal, form homogeneous solution, adding containing hydrogen silicone oil cross-linking agent stirs and is mixed with component two, and the mass fraction of olefin(e) acid cholesterol ester liquid crystal is 5-7.5% in the component two; After doughnut successively soaked component one and component two solution,, liquid crystal/silicone rubber crosslinking is solidified by heating; Apply repeatedly, promptly obtain the doughnut of uniform liquid crystal/silicone rubber crosslinking film on the surface applied;
(2) the graded ceramics inside pipe wall applies from ionpolymeric film
With graded ceramic tube, clean with the ultrasonic concussion of distilled water, then with the abundant vacuum drying of cleaned graded ceramic tube;
With mass concentration is that 0.5-3% pours in the earthenware from aggressiveness solution, and quick slant is placed graded ceramic tube makes the liquid level of solution of pouring into just in time equal with the top bead of graded ceramic tube; Rotate graded ceramic tube and pour out the residue residual liquid after one week; Graded ceramic tube is placed in air, and solution is no longer till the wire drawing, the abundant vacuum drying film forming of graded ceramic tube in waiting to manage;
(3) assembling of artificial lung
With (1) gained doughnut assembling bunchy, load to applying in the graded ceramic tube of ionpolymeric film, use epoxy resin to carry out end-blocking, make described dual pathways doughnut membrane type artificial lung.
4. according to the manufacture method of the described dual pathways doughnut of claim 3 membrane type artificial lung, it is characterized in that: in the described step 1, the molar content of vinyl is 5% in the described silicone rubber; In the described component one, the mass fraction of silicone rubber is 5.0%; In the described component two, the mass fraction of olefin(e) acid cholesterol ester liquid crystal is 5%.
5. according to the manufacture method of the described dual pathways doughnut of claim 3 membrane type artificial lung, it is characterized in that: in the described step (1), the mass fraction of chloroplatinic acid is 0.02～0.05% in the described component one; In the described component two, the mass fraction of containing hydrogen silicone oil cross-linking agent is 0.04～0.06%.
6. according to the manufacture method of the described dual pathways doughnut of claim 5 membrane type artificial lung, it is characterized in that: in the described step (1), the mass fraction of chloroplatinic acid is 0.02% in the described component one; In the described component two, the mass fraction of containing hydrogen silicone oil cross-linking agent is 0.05%.
7. according to the manufacture method of the described dual pathways doughnut of claim 3 membrane type artificial lung, it is characterized in that: in the described step (2), described mass concentration from aggressiveness solution is 1%.
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| ES2619828T3 (en) * | 2011-09-23 | 2017-06-27 | Yoram Palti | Gas exchanger comprises nanotubes and artificial lung |
| DE102013010735A1 (en) * | 2013-06-27 | 2015-01-15 | Mann + Hummel Gmbh | A ceramic whole blood hollow fiber membrane filter medium and use thereof for separating blood plasma / serum from whole blood |
| CN104939946B (en) * | 2015-06-29 | 2017-01-11 | 上海大学 | Method for preparing hollow hydrogel fibers and constructing branch blood vessel unit |
| JP6912426B2 (en) * | 2018-07-25 | 2021-08-04 | 株式会社日本トリム | Hydrogen gas melting device |
| CN112007519B (en) * | 2020-08-17 | 2023-05-02 | 杭州科百特科技有限公司 | Oxygenation membrane, preparation method thereof and oxygenation assembly |
| CN112370589A (en) * | 2020-09-28 | 2021-02-19 | 中国科学院精密测量科学与技术创新研究院 | Artificial lung/artificial kidney device and method |
| CN115920161B (en) * | 2022-07-13 | 2024-05-31 | 心擎医疗（苏州）股份有限公司 | Oxygenator |
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| CN101312758A (en) * | 2005-11-24 | 2008-11-26 | 株式会社Jms | Hollow fiber membrane type artificial lung |
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| CN101312758A (en) * | 2005-11-24 | 2008-11-26 | 株式会社Jms | Hollow fiber membrane type artificial lung |
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