CN101450001A - Novel thrombus cleaning device - Google Patents
Novel thrombus cleaning device Download PDFInfo
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- CN101450001A CN101450001A CNA200710144721XA CN200710144721A CN101450001A CN 101450001 A CN101450001 A CN 101450001A CN A200710144721X A CNA200710144721X A CN A200710144721XA CN 200710144721 A CN200710144721 A CN 200710144721A CN 101450001 A CN101450001 A CN 101450001A
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- shape
- memory
- microdrive
- resistance
- memory polymer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00867—Material properties shape memory effect
- A61B2017/00871—Material properties shape memory effect polymeric
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Abstract
A novel thrombus cleaning apparatus, the invention relates to a thrombus cleaning apparatus of surgical operation in order to solve the problem that the accurate and complicated surgical operation is difficult to perform in a narrow blood vessel cavity. The thrombus cleaning apparatus comprises a shape memory material minitype driver 1, a minitype connector 2 and a minitype vessel 3, the shape memory material minitype driver 1 and the minitype connector 2 are connected and mounted in the minitype vessel 3 together. The invention has simple design and manufacture, can satisfy the requirement that the accurate and complicated surgical operation can be performed in the narrow blood vessel cavity.
Description
Technical field
The present invention relates to a kind of thrombus cleaning device of vascular operation.
Background technology
The alluvial of thrombosis is a kind of common cardiovascular disease in the human vas.Because thrombosis makes lumen of vessels narrow or inaccessible,, can have a strong impact on patient's life even direct life threatening if treat untimely method or method is improper.But because technical reason, traditional treatment is to utilize medicine to make thromboembolism, if directly take thrombolytic, anticoagulant or medicament for expanding vascellum, Time of Administration is long, DeGrain; Or intravenous method, but the general course of treatment is long, but general medicine is the patient at certain stage, and treatment cycle is long, and therapeutic process is relatively more painful, and it is slow to take effect.If with the method for intubate topical, then intubate is many, and need to prepare for a long time, operation is loaded down with trivial details, and can not effect a radical cure.Therefore, how easily and effectively removing thrombosis is the difficult problem that medical circle needs to be resolved hurrily.
When Drug therapy is invalid, just answer the promoting the circulation of blood pipe to cut embolectomy or the operation of femoral vein intersection turn of tidal stream, but these operating danger are very big and surgery cost is expensive.For how effectively to remove thrombosis by surgery, there is the scholar to propose to adopt metal mechanical type expansion structure to remove thrombosis, but, since the blood vessel cavity very narrow and small, this size that requires to remove structure is necessary for micron order, therefore, the design difficulty of this kind metal mechanical structure is very big, is difficult to satisfy accurately and complicated operating requirement.
Along with the fast development of new material, the huge applications that this intellectual material of shape-memory polymer shows especially out gradually at medical domain is worth.Shape-memory polymer is by polymer being carried out molecular combinations and modification, make them under certain condition, being endowed certain shape (playing primary state); When external condition changed, it can correspondingly change shape and be fixed (deformation states).If external environment condition changes once more with rule in a particular manner, they can reversibly return to primary state; So far, finish the circulation of " remembered primary state → fixed deformation attitude → recovered primary state ", this specific character of polymer is called the memory effect of material.Shape-memory polymer deformation-recovery power is bigger, kinetic stability, and reliability is higher, and the shape hold facility is better.The elementary heat of shape-memory polymer-mechanically deform process is: the shape memory shape-memory polymer can apply external force and make its distortion more than glass transition temperature (Tg); Keeping making it be cooled to the following uniform temperature of Tg under the constant prerequisite of external constraint, remove external constraint, the institute's deformation energy of composing quilt is kept for a long time; When being heated to Tg once more when above, shape-memory polymer can automatically revert to the most primary shape.
Along with the development of intellectual material and structure technology, the especially initiatively appearance and the fast development of deformable material such as shape-memory polymer makes its utilization in the vascular surgery field become possibility, and this will promote the development of relevant medical domain greatly.
Summary of the invention
Extremely difficultly in narrow and small blood vessel wall to carry out the difficult problem that mechanical type is removed thrombosis in order solving medically, and to propose a kind of novel thrombus cleaning device of utilizing this intellectual material of shape-memory polymer to design.
Novel thrombus cleaning device of the present invention is by shape-memory material microdrive 1, and microconnector 2 and microguide 3 constitute, and shape-memory material microdrive 1 is connected with microconnector 2 and is loaded in the lump in the microguide 3.Its concrete manufacture process is: shape-memory material microdrive 1 is processed into helical form through curing; Be heated to the above and stretching of softening temperature (Tg) of shape-memory polymer, keeping under the stretching restrained condition it being cooled off the elastic modelling quantity rising of cooling back shape-memory material microdrive 1, hardened material, vertical bar fixed in shape; Be connected with the microconnector 2 in the microguide; Microguide 3 tips of packing into.
The work process of thrombus cleaning device of the present invention is: open one little mouthful at human body shallow-layer blood vessel, thrombus cleaning device of the present invention is transported to the thrombosis position along lumen of vessels.Shape-memory material microdrive 1 is partly released outside the microguide 3 under the promotion of microconnector 2 after microguide 3 tips pass thrombosis 4; Under extraneous heat effect, when the temperature of shape-memory material microdrive 1 is higher than himself Tg, shape-memory material microdrive 1 is because the shape memory effect distortion returns to spiral type, and after cooling, the sclerosis of thrombosis distortion remover, spiral-shaped state are fixed; At last, spiral type thrombosis distortion remover moves, thrombosis 4 is held to drive by dragging microconnector 2 and microtubular 3, and thrombosis distortion remover is taken out of thrombosis from blood vessel 5 external, and blood recovers proper flow.
The shape-memory material of the shape-memory material microdrive among the present invention comprises that pure shape memory polymer material, magnetic-particle strengthen shape memory polymer composite material, resistance wire and strengthen a kind of in the composite material of shape memory.The cross section of shape-memory material microdrive 1 is round, and radius is 10 μ m～2000 μ m, and the radius of microconnector 2 is 10 μ m～1000 μ m, and the internal diameter of microguide 3 is than big 0～1000 μ m of radius of shape-memory material microdrive 1.Shape-memory material microdrive 1 is pushed out into microguide 3 outer length and accounts for 10% to 90% of shape-memory material microdrive 1.
Shape memory polymer material is that polystyrene shape-memory polymer, epoxy resin shape-memory polymer, cyanate are one or more the mixing among a kind of in shape-memory polymer, shape memory polyurethane, shape memory polyester, shape memory SB, shape memory using trans-polyisoprene or the shape memory polynorbornene.
The granule wild phase that magnetic-particle strengthens shape memory polymer composite material is: Ni powder particles, Fe powder, Fe
3O
4In one or more mixing.
The resistance wire material that resistance wire strengthens composite material of shape memory comprises: the mixing of one or more in nichrome resistance material, nickel chromium iron resistance material, siderochrome resistance material, nickel chromium triangle ferro-aluminum resistance material, siderochrome aluminum resistance material, molybdenum resistance material, pure nickel resistance material, copper-manganese resistance material, constantan resistance material, copper nickel resistance material, iron resistance material, copper resistance material, the electric resistance of stainless material.
Since the blood vessel cavity very narrow and small, this size of require removing structure is necessary for micron order, therefore, if thrombus cleaning device is the metal mechanical structure, its design and manufacture difficulty will be greatly, and are difficult to satisfy accurately and the operating requirement of complexity.Crushed element in the thrombus cleaning device provided by the present invention is a shape memory polymer material, physical dimension is a micron order, its design and manufacturing are simple, can be fine satisfy and in narrow and small vessel lumen, carry out complicated and accurate thrombosis is removed the requirement of operation, make thrombosis remove the simple and fast that to become.The application of thrombosis provided by the invention distortion remover medical stent aspect therapeutic treatment has great importance: not only can improve the thrombosis clear quality, shorten thrombus cleaning course of treatment, thereby reduce patient's misery to a great extent; And the cost of treatment is significantly reduced.The subject range of thrombosis provided by the present invention distortion remover is extensive, can be used for spending clearly, severe thrombosis patient.
Description of drawings
The structural representation of Fig. 1, thrombus cleaning device; Fig. 2, thrombus cleaning device work process one sketch map: shape-memory material microdrive 1 is released outside the microguide 3 by microconnector 2 and is passed thrombosis 4; Fig. 3, thrombus cleaning device work process two sketch maps: 1 distortion of shape-memory material microdrive returns to spiral type; Fig. 4, thrombus cleaning device work process three sketch maps: drag microconnector 2 and microguide 3, spiral shape-memory material microdrive 1 drags thrombosis 4 and moves in blood vessel 5, and thrombosis 4 finally is scavenged into external.
The specific embodiment
The specific embodiment one: in conjunction with Fig. 1, Fig. 2, Fig. 3 and Fig. 4 present embodiment is described, the novel thrombus cleaning device of present embodiment is made through the following step: shape-memory material microdrive 1 is processed into helical form through curing; Be heated to the above and stretching of softening temperature (Tg) of shape-memory polymer, keeping under the stretching restrained condition it being cooled off the elastic modelling quantity rising of cooling back shape-memory material microdrive 1, hardened material, vertical bar fixed in shape; Be connected with the microconnector 2 in the microguide; Microguide 3 tips of packing into.In the work process of thrombus cleaning device, shape-memory material microdrive 1 is after microguide 3 tips pass thrombosis 4, under the promotion of microconnector 2, partly released outside the microguide 3, under extraneous heat effect, when the temperature of shape-memory material microdrive 1 is higher than himself Tg, shape memory microdrive 1 is because the shape memory effect distortion returns to spiral type, and after cooling, shape-memory material hardens, spiral-shaped being fixed; At last, shape memory microdrive 1 moves, thrombosis 4 is held to drive by dragging microconnector 2 and microtubular 3, and last thrombosis distortion remover is taken thrombosis out of external from blood vessel 5, and blood recovers proper flow.
The specific embodiment two: present embodiment and the specific embodiment one difference are that the material of shape memory polymer material microdrive 1 is a shape memory polymer material.Comprise that polystyrene shape-memory polymer, epoxy resin shape-memory polymer, cyanate are a kind of in shape-memory polymer, shape memory polyurethane, shape memory polyester, shape memory SB, shape memory using trans-polyisoprene or the shape memory polynorbornene.Microconnector 2 is a fiber optic materials.The heating of shape-memory material microdrive 1 is by heating it by optical fiber, to reach the purpose that shape is recovered.
The specific embodiment three: present embodiment and the specific embodiment one difference are that the material of shape memory polymer material microdrive 1 is that magnetic-particle strengthens shape memory polymer material.Shape-memory polymer comprises that polystyrene shape-memory polymer, epoxy resin shape-memory polymer, cyanate are a kind of in shape-memory polymer, shape memory polyurethane, shape memory polyester, shape memory SB, shape memory using trans-polyisoprene or the shape memory polynorbornene.Magnetic-particle comprises Ni powder particles, Fe powder, Fe
3O
4In one or more mixture.Microconnector 2 is a fiber optic materials.The heating of shape-memory material microdrive 1 applies alternating magnetic field by the external world heats, to reach the purpose that shape is recovered.
The specific embodiment four: present embodiment and the specific embodiment one difference are that the material of shape-memory material microdrive 1 is that resistance wire strengthens shape memory polymer material.The single resistance wire that is enclosed with insullac forms the galvanic circle in the shape-memory polymer matrix material.Shape-memory polymer comprises that polystyrene shape-memory polymer, epoxy resin shape-memory polymer, cyanate are a kind of in shape-memory polymer, shape memory polyurethane, shape memory polyester, shape memory SB, shape memory using trans-polyisoprene or the shape memory polynorbornene.Resistance wire strengthens one or more the mixing comprise in nichrome resistance material, nickel chromium iron resistance material, siderochrome resistance material, nickel chromium triangle ferro-aluminum resistance material, siderochrome aluminum resistance material, molybdenum resistance material, pure nickel resistance material, copper-manganese resistance material, constantan resistance material, copper nickel resistance material, iron resistance material, copper resistance material, the electric resistance of stainless material.Microconnector 2 is that the resistance wire of shape-memory material microdrive 1 exposes outside and the part that is connected with external power source.The heating of shape-memory material microdrive 1 is heated resistance wire by external voltage and is realized, to reach the purpose that shape is recovered.
The specific embodiment five: in conjunction with Fig. 1 present embodiment is described, present embodiment and the specific embodiment one difference are that the cross section of shape-memory material microdrive 1 is round, and radius is 10 μ m～2000 μ m.
The specific embodiment six: in conjunction with Fig. 1 present embodiment is described, present embodiment and the specific embodiment one difference are that the radius of microconnector 2 is 10 μ m～1000 μ m.
The specific embodiment seven: in conjunction with Fig. 1 present embodiment is described, present embodiment is radius big 0～1000 μ m of the internal diameter of microguide 3 than shape-memory material microdrive 1 with the specific embodiment one difference.
The specific embodiment eight: in conjunction with Fig. 2 present embodiment is described, present embodiment and the specific embodiment one difference are that shape-memory material microdrive 1 is pushed out into microguide 3 outer length and accounts for 10% to 90% of shape-memory material microdrive 1.
The specific embodiment nine: in conjunction with Fig. 2 present embodiment is described, present embodiment and the specific embodiment one difference are that shape-memory material microdrive 1 is pushed out into microguide 3 outer length and accounts for 50% to 80% of shape-memory material microdrive 1.
The specific embodiment ten: in conjunction with Fig. 2 present embodiment is described, present embodiment and the specific embodiment one difference are that shape-memory material microdrive 1 is pushed out into microguide 3 outer length and accounts for 70% of shape-memory material microdrive 1.
Claims (7)
1, a kind of novel thrombus cleaning device is characterized in that it comprises shape-memory material microdrive 1, microconnector 2, and microguide 3, shape-memory material microdrive 1 is connected with microconnector 2 and is loaded in the lump in the microguide 3.
2, a kind of novel thrombus cleaning device according to claim 1 is characterized in that the material of shape memory polymer material microdrive 1 is a shape memory polymer material.Comprise that polystyrene shape-memory polymer, epoxy resin shape-memory polymer, cyanate are a kind of in shape-memory polymer, shape memory polyurethane, shape memory polyester, shape memory SB, shape memory using trans-polyisoprene or the shape memory polynorbornene.
3, a kind of novel thrombus cleaning device according to claim 2 is characterized in that microconnector 2 is optical fiber.The heating of shape-memory material microdrive 1 is by heating it by optical fiber, to reach the purpose that shape is recovered.
4, a kind of novel thrombus cleaning device according to claim 1 is characterized in that being that the material of shape memory polymer material microdrive 1 is that magnetic-particle strengthens shape memory polymer material.Shape-memory polymer comprises that polystyrene shape-memory polymer, epoxy resin shape-memory polymer, cyanate are a kind of in shape-memory polymer, shape memory polyurethane, shape memory polyester, shape memory SB, shape memory using trans-polyisoprene or the shape memory polynorbornene.Magnetic-particle comprises Ni powder particles, Fe powder, Fe
3O
4In one or more mixture.
5, a kind of novel thrombus cleaning device according to claim 4 is characterized in that being that microconnector 2 is optical fiber.The heating of shape-memory material microdrive 1 applies alternating magnetic field by the external world heats, to reach the purpose that shape is recovered.
6, a kind of novel thrombus cleaning device according to claim 1, the material that it is characterized in that shape-memory material microdrive 1 are that resistance wire strengthens shape memory polymer material.The single resistance wire that is enclosed with insullac forms the galvanic circle in the shape-memory polymer matrix material.Shape-memory polymer comprises that polystyrene shape-memory polymer, epoxy resin shape-memory polymer, cyanate are a kind of in shape-memory polymer, shape memory polyurethane, shape memory polyester, shape memory SB, shape memory using trans-polyisoprene or the shape memory polynorbornene.Resistance wire strengthens one or more the mixing comprise in nichrome resistance material, nickel chromium iron resistance material, siderochrome resistance material, nickel chromium triangle ferro-aluminum resistance material, siderochrome aluminum resistance material, molybdenum resistance material, pure nickel resistance material, copper-manganese resistance material, constantan resistance material, copper nickel resistance material, iron resistance material, copper resistance material, the electric resistance of stainless material.
7, a kind of novel thrombus cleaning device according to claim 6 is characterized in that microconnector 2 exposes outside and the part that can be connected with external power source for the resistance wire of shape-memory material microdrive 1.The heating of shape-memory material microdrive 1 is heated resistance wire by external voltage and is realized, to reach the purpose that shape is recovered.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200710144721XA CN101450001A (en) | 2007-12-03 | 2007-12-03 | Novel thrombus cleaning device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200710144721XA CN101450001A (en) | 2007-12-03 | 2007-12-03 | Novel thrombus cleaning device |
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| Publication Number | Publication Date |
|---|---|
| CN101450001A true CN101450001A (en) | 2009-06-10 |
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| CNA200710144721XA Pending CN101450001A (en) | 2007-12-03 | 2007-12-03 | Novel thrombus cleaning device |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104994799A (en) * | 2012-11-21 | 2015-10-21 | 香港科技大学 | Low force thrombectomy device |
| WO2019153984A1 (en) * | 2018-02-12 | 2019-08-15 | 中南大学 | Microelectronic controlled magnetic cleaning system and method therefor |
| CN110308514A (en) * | 2019-07-26 | 2019-10-08 | 南京邮电大学 | Microdrive based on optical waveguide structure |
-
2007
- 2007-12-03 CN CNA200710144721XA patent/CN101450001A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104994799A (en) * | 2012-11-21 | 2015-10-21 | 香港科技大学 | Low force thrombectomy device |
| WO2019153984A1 (en) * | 2018-02-12 | 2019-08-15 | 中南大学 | Microelectronic controlled magnetic cleaning system and method therefor |
| US11389182B2 (en) | 2018-02-12 | 2022-07-19 | Central South University | Microelectronic controlled magnetic cleaning system and method thereof |
| CN110308514A (en) * | 2019-07-26 | 2019-10-08 | 南京邮电大学 | Microdrive based on optical waveguide structure |
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Open date: 20090610 |