CN101443065A - Atomiser - Google Patents

Abstract

An atomiser (1) is proposed for the delivery and in particular the atomisation of a formulation (2), particularly a powder. A simple construction and simple intuitive operation are made possible in particular by the fact that the atomiser (1) has a mouthpiece (8) with an associated cover (10), so that opening and/or closing the cover causes a delivery medium, in particular air, to be taken in and/or put under pressure by a delivery device, a spring store is put under tension and/or a preferably annular reservoir containing a plurality of doses of the formulation (2) is further rotated.

Description

Nebulizer

Technical field

The present invention relates to a kind of nebulizer as claim 1,4 or 25 preamble.

The invention particularly relates to sending and atomizing of the preparation that is used to suck or is used for other medical treatment or therapeutic use.Especially preferably, the present invention relates to especially contain sending of at least a active substance or the medical preparation of forming by at least a active substance, pharmaceutical preparation and/or treatment preparation.

The invention particularly relates to a kind of inhaler.Between atomization period, produce have be specifically used for sucking preferred in 1 to 10 mu m range very fine solid and/or the aerosol or the spray cloud of liquid particle.

Preparation is preferably powder.Especially preferably, therefore the present invention relates to a kind of powder inhalator.Yet, preferably also comprise liquid according to terms " formulation " of the present invention, simultaneously term " liquid " should be interpreted as on than broad sense and especially comprise solution, suspension, aaerosol solution (mixture of solution and suspension), dispersion liquid, its mixture or analog.

Following description mainly is sending and atomizing or at a kind of powder inhalator, although the present invention is not limited to this, description also can be used in particular for other inhalers, nebulizer or dispensing device at powder formulation.

The invention particularly relates to a kind of nebulizer with preparation through measuring in advance.Particularly, indivedual dosage are included in the independent container such as chamber, foaming bag, insert, capsule or analog, and can individually be taken out and atomize.

Background technology

Basically, there are passive type nebulizer and active nebulizer.In the passive type type, the air flow that preparation is produced when sucking or breathe via user and discharging.In active type, preparation is discharged during sucking and is had nothing to do with breathing, and can trigger and send by so-called respiratory triggering particularly by suction process.Particularly, produce flowing by nebulizer or inhaler self such as the delivery media of air or a certain other gases so that delivery formulation.For reaching this purpose, nebulizer has the delivery apparatus such as air pump or pressurized gas tank.The advantage that active type is better than the passive type type is, in active type, can be independent of user and reach preparation be very easy to reproduce sending and atomizing.

EP 0 950 423 B1 disclose a kind of medium active dispensing device of (particularly, powder) that is used for, and this dispensing device has a compressed air pump (that is to say piston pump) that is incorporated in the dispensing device.Dispensing device has a foaming disk, and this foaming disk has a plurality of foaming bags that contain powder that are configured to circle.For activating or open indivedual foaming bags, move axially casing part.

EP 1 132 104 B1 prompting is a kind of to be used to send the active dispensing device that contains from the medium of at least a medicinal activity material of foamed strip.This dispensing device has a fluid that is used to discharge medium (particularly, air) pump, is used for setting up the impact that fluid is communicated with and follows closely (impact spike) and a transverse actuating device between pump and foaming bag, when activating, this transverse actuating device is located the foaming bag and medium is discharged with respect to impacting nail.Dispensing device also has a spring, this spring is being in tension and can be during second actuation step be released into slack position by discharging a breech lock during first actuation step, spring make successively with respect to impact nail locate the foaming bag, by impact nail open foaming bag and air supply to the foaming bag so that discharge medium.

WO 91/06333 A1 discloses a kind of active dispensing device with a hollow cylindrical storage, and this storage comprises a plurality of axially extended chamber that contains powder.By axially promoting dispensing device together, compressed air and finally carry air so that discharge dosage of powder out of the ordinary in piston pump via chamber out of the ordinary.

US 5,533, and 502 A disclose a kind of passive type powder inhalator with an annular storage (particularly, foaming), and this annular storage has a plurality of containers that are used for powder.Storage is retained in the inhaler rotationally by a carriage.Can be by means of axially outstanding knob carriage selecting next container, and carriage can move axially so that pierce through container.Yet this mode does not allow to be easy to operation.In fact, during sucking, user must be retained on the state of moving axially with knob or carriage.After release, carriage and storage by the effect of spring force and be back to carriage away from the axial home position that pierces through element.

Summary of the invention

Target of the present invention is for providing a kind of nebulizer, and this nebulizer can (particularly, operation while its simple structure and with low cost, and/or this nebulizer intuitively) be of compact construction, and has low whole height particularly very simply.

Above Chen Shu target is by by solving as claim 1,4 or 25 nebulizer.Other are characterized as the theme of dependent claims.

According to a first aspect of the invention, the cover of the mouthpiece of nebulizer is coupled to such as the delivery apparatus of pump and/or such as the spring energy stored and stores, and makes that opening and/or close cover actuating delivery apparatus and/or produce power and energy is stored in the energy storage.Particularly, when opening cover, delivery media (being preferably air) is absorbed into and/or places under the pressure by delivery apparatus.Perhaps or in addition, preferably store and store by opening and/or close the energy that cover produces by back-moving spring.Therefore, very simply and particularly operating intuitively of nebulizer becomes possibility.In addition, this feasible structure can keep simple especially and therefore also with low cost.For instance, may not need to have the individually actuating element that is used to operate delivery apparatus or pump and/or is used for back-moving spring storage or analog.

According to the second aspect that also can independently implement of the present invention, nebulizer has a gear or driver, its be used for from cover open and/or closing movement produce preferred axially-movable with open next container, this storage that is used for moving container and/or move forward one by one, the enumerator or other devices that are used for the back-moving spring storage, are used to activate delivery apparatus (particularly, being used to be absorbed into air) and/or are used to activate nebulizer.This obtains simple, compact structure, especially when gear or driver are configured in the loop configurations of storage or container.

In the third aspect that also can independently implement of the present invention, nebulizer has one and is independent of the cut out chamber that storage is used to hold medicament.This obtains having simple, the compact structure of the agent capacity of increase.

Description of drawings

The further aspect of the present invention, feature, character and advantage will become clear from following explanation of preferred embodiment being carried out with reference to accompanying drawing and claim, wherein

Fig. 1 illustrates the schematic cross-sectional according to the proposed nebulizer that is in transmission location of first embodiment;

Fig. 2 illustrates the schematic cross-sectional of the nebulizer of starting state that is in according to Fig. 1;

Fig. 3 illustrates to be in and opens or the perspective view of the nebulizer of starting state;

Fig. 4 a illustrates the sketch map according to the rail plate in the nebulizer of Fig. 1;

Fig. 4 b illustrates the sketch map according to the nebulizer of opening or excise a part with ratchet mechanism of Fig. 1;

Fig. 4 c illustrates the schematic cross-sectional according to the nebulizer with locking device of Fig. 1;

Fig. 4 d illustrates the perspective view according to the control loop of the locking device of Fig. 4 c;

Fig. 4 e illustrates another schematic cross-sectional according to the nebulizer with locking device of Fig. 4 c;

Fig. 5 illustrates the schematic cross-sectional according to the nebulizer after sending or atomizing of Fig. 1;

Fig. 6 illustrates the schematic cross-sectional according to the proposed nebulizer that is in transmission location of second embodiment;

Fig. 7 illustrates according to being in of Fig. 6 and starts or the schematic cross-sectional of the nebulizer of open mode;

Fig. 8 illustrates according to being in of the 3rd embodiment and opens or the schematic cross-sectional of the proposed nebulizer of starting state;

Fig. 9 illustrates the sketch map according to the proposed nebulizer 1 that is in transmission location of the 4th embodiment;

Figure 10 illustrates the not schematic cross-sectional of the nebulizer of latch mode that is in according to Fig. 9;

Figure 11 illustrates the schematic cross-sectional of the nebulizer of the state that starts, is pressed together according to being in of Fig. 9;

Figure 12 illustrates the schematic cross-sectional according to the proposed nebulizer that is in transmission location of the 5th embodiment;

Figure 13 illustrates the not schematic cross-sectional of the nebulizer of latch mode that is in according to Figure 12;

Figure 14 illustrate according to being in of Figure 12 start, the schematic cross-sectional of the nebulizer of coarctate state;

Figure 15 illustrates the schematic cross-sectional according to the proposed nebulizer that is in transmission location of the 6th embodiment;

Figure 16 illustrates the not schematic cross-sectional of the nebulizer of latch mode that is in according to Figure 15;

Figure 17 illustrates the sketch map according to the Connection Element of the nebulizer of Figure 16;

Figure 18 illustrates another exemplary details from Figure 16;

Figure 19 illustrates the side view according to the details of the nebulizer that is in transmission location with enumerator of Figure 15;

Figure 20 illustrates the not side view of the nebulizer of latch mode that is in corresponding to Figure 19;

Figure 21 illustrates the perspective view according to the nebulizer with timer of Figure 15;

Figure 22 illustrates the perspective view according to the nebulizer with medicine container of Figure 15;

Figure 23 illustrates the schematic cross-sectional according to the proposed nebulizer that is in transmission location of the 8th embodiment;

Figure 24 illustrates according to being in of Figure 23 and opens or the schematic cross-sectional of the nebulizer of starting state;

Figure 25 illustrates the sketch map according to the transmitting device of the nebulizer of Figure 23;

Figure 26 illustrates the sketch map according to the part of the proposed nebulizer of the 9th embodiment;

Figure 27 illustrates the view of the nebulizer of starting state that is in corresponding to Figure 26;

Figure 28 illustrates the schematic functional representation according to the proposed nebulizer of the tenth embodiment; And

Figure 29 illustrates the schematic cross-sectional according to the nebulizer of Figure 28.

At Zhu Tuzhong, same reference numbers is used for identical or like parts, even the description that does not repeat to be associated.Particularly, obtain identical whereby or corresponding advantages and character.

The specific embodiment

Fig. 1 illustrates the proposed nebulizer 1 that is in transmission location according to first embodiment with schematic cross-sectional.Particularly, nebulizer 1 is for especially being preferred for the preferred portable type inhaler of treatment by aerosol.

Nebulizer 1 is through the preparation 2 of design to send and to atomize and be preferably powder.Particularly, the implication that can above be explained of nebulizer 1 is used for preparation 2.

Preparation 2 is preferably through the indivedual dosage that are specifically used for suck of metering in advance for being sent in succession by nebulizer 1.

Nebulizer 1 have storage 3 or through the design with fixing one storage.If necessary, storage 3 can be inserted in the nebulizer 1 and optionally be changed to reuse nebulizer 1.

Storage 3 has a plurality of containers 4, and each container 4 contains the preparation 2 of a dosage.Container 4 can be (for example) foaming bag, but preferably contains the insert 28 of the preparation 2 with dosage out of the ordinary.Storage 3 preferably has rigidity and/or circular structure.Particularly, storage 3 or container 4 form loop configurations, these container 4 preferred circle distribution around storage 3.

Nebulizer 1 is preferably active type.In with the embodiment shown in the example, nebulizer 1 preferably has the delivery apparatus 5 of the delivery media (being in particular air or a certain other gases) that is used for delivery formulation 2.Particularly, delivery apparatus 5 is configured to pump (especially being preferably air pump) or designs to carry delivery media with a certain additive method.

Particularly, delivery apparatus 5 has a pump chambers 6, and pump chambers 6 is preferably formed, delimits and/or changed by flexible capsule 7 and/or a certain other elements of delivery apparatus 5.

Use delivery apparatus 5, particularly, surrounding air can be used as delivery media and is absorbed into and is under pressure.Use delivery media, can be when activating or use nebulizer 1 (particularly, only after corresponding triggering nebulizer 1) discharge preparations 2 from container 4, that is to say the preparation 2 of a dosage.Yet, delivery apparatus 5 in theory can also a certain other modes produce, provide and/or pressurize as the air of delivery media, other gases or even liquid so that delivery formulation 2 is as aerosol with preferred finely particulate (solid and/or liquid) or spraying mist particularly.

Nebulizer 1 preferably has one and is used for (particularly) extremity piece or mouthpiece 8 to user or sufferer (not shown) delivery formulation 2.To only use term " mouthpiece " from now on.Yet, this mouthpiece also can be used to throw with or a certain other extremity pieces of delivery formulation 2, especially when nebulizer 1 is not used as inhaler.

The opening of sending of mouthpiece 8 optionally possesses grid 9 or other protective elements; particularly so as can to prevent by external effect or analog cause to nebulizer 1 (for example; storage 3 or container 4) damage, and/or prevent that other parts, big microgranule or analog from discharging.

Nebulizer 1 preferably has a cover 10 that is associated with mouthpiece 8, with the removable cover 10 of hands, particularly so that mouthpiece 8 can be opened and close.Fig. 1 illustrates the cover 10 that is in closed condition (that is to say, cover mouthpiece 8).Fig. 2 is illustrated in cover 10 with similar cutaway view and opens the nebulizer 1 (that is to say that nebulizer 1 is ready for suction) that has started under the situation of (that is to say, can be free near mouthpiece 8).

Particularly, cover 10 can move (particularly, slidably and/or rotatable) with indicated delivery side among Fig. 2 with meeting at right angles to 11.

In example embodiment, cover 10 preferably can or rotate around the pivot center rotation of the central axis 12 of the loop configurations of nebulizer 1 or storage 3 or container 4 or storage 3.Nebulizer 1 or its shell 13 be particularly with respect to axis 12 rotation-symmetric at least in fact preferably, and/or structure is to be essentially at least smooth or discous, particularly the shape of rounded in fact dish.Yet other geometry and structure solution and configuration also are possible.

Cover 10 preferably can move with the shell 13 of nebulizer 1 tangently or can move along the periphery of nebulizer 1.Particularly, cover 10 extends along periphery in fact, extends along the circumferential sectors of nebulizer 1 particularly.

Fig. 3 illustrates a preferable configuration of nebulizer 1, particularly, and one smooth, plate-like and/or circular embodiment.Also apparent, cover 10 covers or preferred 90 ° of overlapping nebulizer 1, about in fact 150 ° to 170 ° circumferential section particularly at least, particularly on peripheral direction and from a planar side via this circumferential section to another planar side.Yet other structure solutions and configuration equally also are possible herein.

In shown embodiment, in the fully open position shown in Fig. 2 and Fig. 3, cover 10 preferably rotates with respect to the transmission location of closing shown in Fig. 1 or rotates about 150 ° to 180 °.Yet other anglecs of rotation also are possible.

Perhaps, cover 10 can (for example) with the mode of slide plate and/or baffle plate form and can (for example) by shell 13 or mouthpiece 8 guide, installation or fixing.

Cover 10 preferably is coupled to delivery apparatus 5, makes to operate or activate delivery apparatus 5 by opening and/or close (and particularly only by opening) cover 10, and is absorbed into delivery media (surrounding air particularly) by delivery apparatus 5 particularly.Perhaps or in addition, can opening and/or closing movement and delivery media is under pressure by cover 10.Under this situation, owing to realize the actuating of delivery apparatus 5 intuitively by opening and/or close cover 10 and, be very simply and intuitively so operate particularly without any need for any additional actuated of other actuation elements.

Nebulizer 1 or delivery apparatus 5 preferably have an energy storage, store for the spring that is spring 14 forms in shown embodiment particularly.Cover 10 preferably is coupled to energy storage so that by opening and/or close cover 10 produce powers and storing energy in the energy storage.Particularly, opening and/or close (especially preferably only closing) cover 10 makes and to store or spring 14 and storage power by back-moving spring.

Energy storage or spring store and can drive various devices and/or be used for different purposes, and be specifically used for driving delivery apparatus 5 or delivery media be under pressure or delivery media is shifted out from pump chambers 6, so that discharge the preparation 2 of corresponding dosage and then make its atomizing via the container transport delivery media and in wanted mode.Preferably only during delivery formulation 2 or for delivery formulation 2, delivery media is under pressure.Yet in theory, this also can take place in advance, under this situation, provides valve gear or similar device (not shown), particularly with prevent reality desired send and atomize before send this delivery media and preparation 2 too early.

Energy storage preferably is associated with delivery apparatus 5 or forms a part of delivery apparatus 5.Especially preferably, energy storage or spring store around delivery apparatus 5 or are configured or are incorporated in the delivery apparatus 5.

In with the embodiment shown in the example, spring 14 is installed in respect to the direction of pump or pumping action and extends axially or be installed in after pump chambers 6 or the flexible capsule 7.Under this situation, spring 14 preferably serves as the compression spring, its compression or driving pump chamber 6 or flexible capsule 7 or mobile (for example) piston (not shown), contained delivery media (that is to say in the size of pump chambers 6 or the compressor pump chamber 6 so that reduce, delivery media is under pressure), and reach sending of delivery media whereby.

Delivery apparatus 5 and/or energy storage especially preferred disposition are configured in the center of shell 13 particularly so at least in fact in the loop configurations of storage 3 or container 4.Preferably, delivery apparatus 5 and energy storage are configured in the zone of axis 12 or are configured and around axis 12, preferably are configured and concentric with axis 12.

According to the present invention, delivery apparatus 5 and/or energy storage or other devices are configured in also make delivery apparatus 5 and/or energy storage to extend axially in the loop configurations of storage 3 or container 4 to exceed storage 3 or container 4, or (for example) makes delivery apparatus 5 and/or energy storage can be configured in the axial dipole field position of the principal plane of storage 3 or planar annular in the transmission location shown in Fig. 1.

Delivery apparatus 5 and/or energy storage are configured in the especially compact structure and the especially lower particularly axial height of atomized device 1 in the loop configurations of storage 3 or container 4 or other devices.

With more detailed description, preferably corresponding to the axis 12 of the loop configurations of storage 3 or container 4, storage 3 preferably can rotate around this axis cover 10 rotation axis as hereinafter.

Nebulizer 1 preferably has a driver or gear 15, and it is specifically used for as above mentionedly will covering 10 and preferably being coupled to delivery apparatus 5 and/or energy storage.Perhaps or in addition, driver (hereinafter being called gear 15) also can drive and/or activate other devices or carry out other functions.

Preferably, gear 15 partly or entirely is configured in the loop configurations of storage 3 or container 4.This promotes the compactly designed of nebulizer 1 again.

Gear 15 preferably drives by the motion of cover 10, and directly or indirectly is coupled to cover 10 particularly.

Especially preferably, by opening and/or closing movement of cover 10, gear 15 produces axially-movable with respect to loop configurations and/or axis 12 particularly.Especially preferably, axially-movable is extended or 12 extensions of paralleling to the axis on axis 12 or along axis 12.It is that at least one component in the motion that is produced by gear 15 on the power outlet side extends on axial direction mentioned above that term " axially-movable " is interpreted as looking like.

Can especially be preferred for opening next container 4 by the axially-movable that gear 15 produces, be used for moving and/or reach storage 3 or container 4, be used for another device that back-moving spring stores, is used to activate delivery apparatus 5 (being specifically used for being absorbed into air) and/or be used to activate nebulizer 1 (such as, enumerator).Preferably, gear 15 has the different drive ratios that is used to drive different device on the power outlet side.

Gear 15 preferably includes at least one screw thread, and one rotatingly has a screw shell 16 particularly, and it especially preferably has female thread 17 and/or external screw thread 18.

Screw thread or have screw shell 16 preferably couple directly or indirectly or be connected to cover 10 and/or with the rotation axis arranged coaxial of cover 10, or form the rotation axis of cover 10.Particularly, the rotation of cover 10 directly causes has screw shell 16 to rotate.

In shown embodiment, delivery apparatus 5 and particularly and energy storage can preferably drive in the axial direction or activate via female thread 17 by gear 15 (particularly).Female thread 17 preferably meshes with the inside meshing part 19 that comprises complementary threads part or other outthrust, mating surface or analog particularly, and making has the rotation of screw shell 16 to cause the axially-movable of the nonrotational meshing part 19 that is associated with delivery apparatus 5 or energy storage.

Particularly, spring 14 at one end (for example) and be coupled to the flexible capsule 7 of delivery apparatus 5 or the movable terminal of other pumping elements by means of end plate or analog and be supported on the meshing part 19 that is preferably formed corresponding spring seat or bearing at other end place.Yet different structure solutions still also is possible.Particularly, gear 15 or meshing part also can only act directly on flexible capsule 7 or other pumping elements, and only are coupled to spring 14 in addition indirectly or are not coupled to spring 14 fully.

Begin from the transmission location shown in Fig. 1, when cover 10 is opened, on the one hand, meshing part 19 moves axially, that is to say, it carries out preferred axially-movable, and on the other hand, preferred chain and/or releasable connection part between meshing part 19 and delivery apparatus 5 and/or spring storage (for example, by means of at least one lock arm 20) the transmission axially-movable, and cause that particularly pump chambers 6 increases in the axial direction and preferably is absorbed into surrounding air, flexible capsule 7 is pulled in the axial direction to be opened or increases, and/or preferred disposition at the center or the actuation element 21 of axial arrangement be released and/or axially outwards shift out (especially when reaching the axial end position), as shown in the end position in Fig. 2.Spring 14 through tension preferably moves axially with the axial end of meshing part 19 and flexible capsule 7.

Between the follow-up period of energization of actuation element 21,, initially send and atomize from the preparation 2 of adjacent vessel 4 particularly by radially inwardly pushing.Particularly, meshing part 19 on the one hand with at least one lock arm 20 between be connected or on the other hand with delivery apparatus 5 and/or energy storage between be connected particularly because at least one engaged element 22 springs into the fact of disengaged orientation (radially inside in shown embodiment) with at least one lock arm 20 and sets up.As hereinafter with more detailed argumentation, spring stores or causes that then flexible capsule 7 is compressed and make that pump chambers 6 is littler through the resilience or the spring force of back-moving spring 14, as its result, contained delivery media (particularly in the pump chambers 6, surrounding air) be under pressure and be moved out of, thereby preparation 2 is discharged from wanted mode and atomizes.

Replace screw thread or except that screw thread, can use a certain other control cams, slope, clinoplain or other gear drives to connect in theory, to reach motion sequence as described above, hereinafter described motion sequence and/or a certain other motion sequences particularly.

Nebulizer 1 preferably have a transmitting device 23 so that storage 3 can be preferably step by step or one by one container 4 ground reach or further turn to next container 4, and preferably have a connecting device 24, it is used for particularly these containers 4 being connected to delivery apparatus 5 severally and/or being specifically used for individually opening container 4.

Preferably, by cover 10 opening and/or closing, drive or activate transmitting device 23 and/or connecting device 24 particularly via gear 15.Especially preferably, reuse the axially-movable that produces by gear 15.

In shown embodiment, the actuating of the actuating of transmitting device 23 and connecting device 24 (that is to say, storage 3 is moved forward to next container 4 and open next container 4 and/or be attached to delivery apparatus 5) is combined or is coupled.Yet these activate also can control independently of one another or control via the independent driving of gear 15 or independent drive chain particularly.

Preferably, drive by means of the combination of reaching transmitting device 23 and connecting device 24 with the external engagement parts 25 of external screw thread 18 engagement that screw shell 16 is arranged (particularly via corresponding have threaded portion, slidingsurface or analog).This meshing part 25 is connected to preferred annular storage 3 specifically non-rotatingly or is formed by storage 3.For instance, meshing part 25 can form a sealing internal ring of storage 3.Yet this meshing part 25 is not indispensable.For instance, storage 3 also can be via the slidingsurface of correspondence or analog and with directly engagement of gear 15 (external screw thread 18 that screw shell 16 is arranged particularly).

Storage 3 is preferably locked to prevent and to have screw shell 16 or external screw thread 18 freely to rotate around axis 12, particularly by (for example) rail plate with shell 13 cooperations formation at its outer periphery place.

Rotation has screw shell 16 or external screw thread 18 (or other control cams) to cause non-co-rotation meshing part 25 and the therefore axially-movable of storage 3.For instance, during cover 10 open and as the result who opens of cover 10, that is to say that by means of gear 15, the axial location of storage 3 in the transmission location shown in Fig. 1 with container 4 moves axially to the position shown in Fig. 2.In shown embodiment, this axially-movable or lifter motion are carried out on the direction opposite with the axially-movable that is used to activate delivery apparatus 5 (particularly, being absorbed into surrounding air) but also can be carried out on same direction.

Only activated back (that is to say, sending and atomize) and closed cover 10 once more from preparation 2 back of container 4 at actuation element 21.Close cover 10 and make screw shell 16 rotations causing storage 3 carry out opposite axially-movable or lifter motion once more.In this axially-movable process and/or opening in the opposite shaft orientation motion of cover during 10, rail plate causes storage 3 container 4 ground reach or further rotate (that is to say, to next container 4) one by one.

The rail plate that Fig. 4 a explanation is preferably formed by the inwall of shell 13 or the possible structure configuration of control flume or control cam 26 are so that carry out the desired preferred alternately axially-movable and the storage 3 progressively further rotation of container 4 one by one of storage 3.Particularly, this aggregate motion is reached by the extension, diagonal angle that alternately axially reaches of control cam 26, and the outthrust of (for example) storage 3 radially is engaged in these parts.Yet other inner radial and/or axial means also are possible.

In shown embodiment, external engagement parts 25 and above-mentioned rail plate form transmitting device 23 or its assembly.Particularly, rail plate or transport sector are constructed (reciprocal axial motion causes progressively rotation) in the mode of ball point pen mechanism.Yet other structure solutions also be possible, and these structure solutions cause storage 3 progressively to move forward or further rotation on container 4 ground one by one particularly, especially preferably by the axially-movable and/or the rotation of all gear assemblies if any screw shell 16.

According to the alternate embodiment shown in Fig. 4 b, replace rail plate or control cam 26 or except that rail plate or control cam 26, transmitting device 23 can have ratchet mechanism or the bolt latch mechanism 27 that (particularly) allows storage 3 progressively move forward or further rotate, and this storage 3 is opened shown in graphic or cuts away a part.Ratchet mechanism 27 is formed between external engagement parts 25 and the annular storage 3 particularly, makes these both can relative to each other rotate on a direction by corresponding ratchet step (ratchet step).

In shown embodiment, ratchet mechanism 27 has a ratchet 27a particularly, and transfer arm 27b can mesh in this ratchet 27a.Especially preferably, the locking radial engagement takes place.Yet engagement also can occur in the axial direction on the principle.Preferably, ratchet mechanism 27 is formed on inside and/or forms around storage 3.Transfer arm 27b can especially preferably move in an alternating manner by delivery apparatus 5 (gear 15 particularly).In shown embodiment, transfer arm 27b directly or indirectly has been connected to screw shell 16, is formed on particularly on the external engagement parts 25.Preferably, transfer arm 27b towards ratchet 27a elastic biasing (particularly, by its intrinsic elasticity) to produce desired locking mesh.Especially preferably, provide a plurality of transfer arm 17b with by cover 10 or the reciprocating motion of screw shell 16 is arranged or rotate the desired reliably progressively motion obtain storage 3.

Now with the preferable configuration of more detailed description connecting device 24.Yet,, at first will be explained in more detail the preferred embodiment of storage 3 for ease of understanding.

For the structure and configuration of storage 3 and container 4, there are various probabilities.For instance, it can be optionally and disposes with the foaming of carriage or analog combination.Then (for example) forms individual containers 4 by the foaming bag.

Especially preferably, form container 4 by insert 28, these inserts 28 are contained in storage 3 the preferred guide rail that separately, radially extends particularly or take in the chamber 29.Particularly, but each insert 28 preferred radial displacement or move.

In shown embodiment, particularly, insert 28, take in chamber 29, mouthpiece 8 and/or delivery apparatus 11 arranged radiallys.Yet, also may have different the arrangement in theory, for example, axially-aligned.

Take on the outer periphery that chamber 29 preferably is provided at storage 3 with opening 30 or loop configurations, when not using or be in state when supplying with, these openings 30 are preferably and close, particularly sealing or otherwise be closed or cover.Corresponding sealing, paper tinsel, thin film or analog is by 30 indications of the reference marker among Fig. 1.As state when supplying with in, contain insert 28 take in chamber 29 each particularly with fluid sealing mode and also may seal with air tight manner with being hedged off from the outer world.Storage 3 is made by the non-proliferation plastics particularly and/or is optionally possessed the diffusion outer enclosure.

Each insert 28 has a storage chamber 31, and it contains the dosage of specific insert 28 or preparation 2 and has been filled with preparation 2 particularly during factory makes storage 3 or nebulizer 1.32 preferred connections with storage chamber 31 to be used for delivery formulation 2 of passage in the insert 28, this passage 32 can (if needs) be integrated with in the nozzle (not shown) or form this nozzle.In shown embodiment, therefore insert 28 is formed for the container 4 of preparation 2 with its storage chamber 31.

Be delivery formulation 2, open container 4 out of the ordinary.In shown embodiment, this preferably delivery end by particularly via opening 30 with insert 28 parts out of the ordinary shift out its take in chamber 29 and via opening 30 radially outward promote the sealing or analog (not shown) carry out.In this way, take in that chamber 29 or its opening 30 are opened and passage 32 exposes.For instance, the sealed foil or the analog (not shown) of sealing respective openings 30 tear off from insert 28, or another closure or the coating member of sealing opening 30 are moved, open, release or otherwise remove from insert 28.

In shown embodiment, distinctly take in preferably moving radially preferably of chamber 29 inserts 28 and carry out for opening, axially thrust the desired outward radial of taking in chamber 29 and carrying out insert 28 by corresponding slidingsurface (on finger piece 33 and/or insert 28) particularly particularly by the finger piece 33 that makes connecting device 24 or other actuated components in the zone of the inner radial end in insert 28 out of the ordinary particularly and move and carry out by means of connecting device 24 or transmitting device 23.

For example because storage 3 has enough thin wall or have easily broken point in thrusting the zone, so thrusting of finger piece 33 is possible.Perhaps, storage 3 also can comprise an opening or analog, and it is sealed, cover or possess closure and can be opened or be thrust by finger piece 33.

Fig. 1 with the cross section on the left side illustrate still close take in chamber 29, wherein insert 29 is not radially pushed as yet.Fig. 2 be illustrated in be opened on the outlet side take in chamber 29, the insert 28 that has wherein moved radially is outstanding from opening 30.

In this embodiment, connecting device 24 has one and is used for setting up the Connection Element 34 that the fluid that is used to supply with delivery media is communicated with container 4 out of the ordinary, make particularly can (for example) via as (that is to say via container 4 out of the ordinary by the passage 35 of sending shown in the delivery apparatus 5, insert 28 out of the ordinary or its storage chamber 31) Connection Element 32 supply with delivery media, thereby be used to send the preparation of dosage out of the ordinary and the preparation of the dosage out of the ordinary that is specifically used for atomizing.

Fluid is communicated with preferably also to be set up with respect to the axially-movable of shell 13 or Connection Element 34 by storage 3.Particularly, finger piece 33 at first axially is engaged on and distinctly takes in the chamber 29 so that moving next insert 28 with use in the radial direction.After this radial motion, along with axially-movable continues, Connection Element 34 is engaged on to be taken in the chamber 29 and is engaged in the insert 28.For this reason, Connection Element 34 is configured to pierce through element particularly, for example be to have the corresponding most advanced and sophisticated intubate or the form of pin so that auxiliary particularly carry out storage chamber 31 pierce through or other thrust to set up desired fluid and are communicated with.Thereby, provide delivery media to the fluid of storage chamber 31 to be communicated with and delivery media can be supplied to storage chamber 31 to discharge preparation 2.

In shown embodiment, external engagement parts 25, finger piece 33 and Connection Element 34 form connecting device 24 or its assembly.Yet, other structure solutions are possible, open or pierce through with connecting these containers 4 or optionally open or sting the container 4 that is through on the supply side and/or on outlet side being used to, and/or be used for these containers 4 are connected to delivery apparatus 5, or another fluid that is used to set up the direct supply that for example is used for surrounding air or suction is communicated with, and is specifically used for preferably radially that (but optionally also axial) moves relevant insert 28, be used for opening respective openings 30 of taking in chamber 29 and/or the supply that is used for the storage chamber 31 of insert 28 is connected to delivery media, be specifically used for Connection Element 34 is inserted in the storage chamber 31.

In shown embodiment, particularly, axially-movable causes via connecting device 24 to be opened, connects or pierce through, preferably with the delivery side to 11 or the throughput direction of container 4 or the motion or the rotation direction of storage 3 meet at right angles.Particularly, execution axially connects or pierces through in shown embodiment.Yet radially or other connections or also pierce through basically to possible, and (if necessary) also can be provided by means of the axially-movable that is provided by gear 15 or carry out for this.

In theory, the direction 11 that connects, opens, pierces through and/or send can radially be moved.

Especially preferably, connecting device 24 (particularly as delivery apparatus 5 and/or transmitting device 23) can activate by opening and/or cut out cover 10 and/or can activate by preferred common gear 15 or at least one axially-movable.

Another feature according to hereinafter explaining referring to alternate embodiment also may be configured in transmitting device 23 and/or connecting device 24 in the loop configurations of storage 3 or container 4.The axial height that this promotes the especially compact structure of nebulizer 1 again and helps to minimize nebulizer 1 particularly.

Storage 3 is preferably inflexible.Adopt term " rigidity " to mean storage 3 or its and take in that chamber 29 is preferably formed the holder of enough stablizing or well defining that is used for insert 28 and may be guide rail.Yet other structure solutions are possible.For instance, take in will guiding of contained insert 28 in the chamber 29 by externally guiding storage 3 or distinctly take in chamber 29, may reaching, even (for example) storage 3 is not to be rigid construction.Perhaps or in addition, in order to connect container 4,, or, can remove insert 28 fully from storage 3 in order to send dosage out of the ordinary maybe when opening when taking in chamber 29.Under this situation, particularly, storage 3 also can (for example) only be configured to blister pack or other encapsulation.

Fig. 2 illustrates the nebulizer 1 that is in starting state.Surrounding air is inhaled in the pump chambers 6.Spring 14 is tightened up.The selected container 4 that is used to send next dosage has been opened and has connected, and corresponding insert 28 has radially outward been promoted and be connected to by means of Connection Element 34 (being pierced through by Connection Element 34 particularly) supply of delivery media.

In shown embodiment, the actual delivery of taking in preparation contained in the chamber 29 2 or dosage through piercing through reaches atomizing particularly only can be after correspondence triggers or further activates (for example, cover 10 another or further activate after) but take place as the result of actuation element 21 particularly, actuation element 21 preferably only axially outwards moves under this state, is axially inwardly pushed and is activated by user or sufferer (not shown) particularly.This latch or other mesh components make spring store or spring 14 can relax.Delivery media in the pump chambers 6 is under pressure and is delivered in the connection storage chamber 31 via sending passage 35 and Connection Element 34.Delivery media continues to flow through passage 32 and flows out insert 28, and contained preparation 2 is discharged from the storage chamber 31 simultaneously.Gained aerosol or spray cloud are sent via mouthpiece 8 via selecting grid 9, the preparation 2 that makes user or sufferer to suck to have sent and atomized particularly.

Fig. 5 illustrates after the suction nebulizer 1 of (that is to say that, container 4 14 lax at spring is for empty and cover 10 and still open under the situation) with schematic cross-sectional.

After sucking or after the delivery formulation 2, close cover 10 once more.This finishes on opposite rotation direction particularly.Because what provided couples (particularly, by means of gear 15), inner meshing part 19 moves back into it in the axial direction once more in the original position shown in Fig. 1, spring storage simultaneously or spring 14 are strained once more, and finally rebulid meshing part 19 and delivery apparatus 5 or spring between storing be operatively connected or other axially are connected (particularly via latch wall 20), make to relax and will keep being connected the original position shown in Fig. 1 under the situation about rebuliding between capsule 7 and/or the spring 14 with stretching particularly at meshing part 19 at spring 14.In addition, storage 3 moves back into its axial home position, that is to say, is axially promoted back in the opposite direction.Particularly, this discharges storage 3 from finger piece 33 and from Connection Element 34.

When connecting device 24 (its finger piece 33 and Connection Element 34 particularly) no longer is engaged in the storage 3 but allows desired rotational motion, storage 3 reach or the further rotation of container one by one preferably is superimposed upon in the axially-movable, and this (that is to say, opening and/or the down periods of cover 10) during cover 10 move up and down all the time and takes place.In shown embodiment, rail plate or control cam 26 therefore preferably through design make storage 3 one by one container 4 to move forward or further rotate an only part in axially-movable during take place.

Measure described above is had very compact, the simple structure of the nebulizer 1 of few components particularly.

Proposed nebulizer 1 can very simply and intuitively be operated.In essence, operation nebulizer 1 is needed only for opening and cut out cover 10.The all functions of imagination or process are triggered whereby or control or generation automatically.Except that cover 10 actuating, when nebulizer 1 being configured to active nebulizer 1, it triggers actual delivery and atomizing after only remaining on and opening cover 10.This preferably finishes by activating (pushing particularly) actuation element 21.Since actuation element 21 only be preferably and be activated at nebulizer 1 (that is to say that cover 10 has been opened) actuatable afterwards, axially shift out and/or can be approaching, therefore make simple intuitive operation become and may and get rid of maloperation.

Actuation element 21 is particularly by the opening in the cover 10.Yet different herein embodiment equally also is possible.In addition, actuation element 21 also may be in the starting state of nebulizer 1 can be by near (for example, appearing) by cover 10.

After suction, can close nebulizer 1 once more or cover 10.Preferably,, that is to say, in shown embodiment, still be in axially extended position as long as actuation element 21 do not activated as yet, or oneself be opened or connect or container 4 delivery formulations 2 that pierce through before, cover 10 is against closure and fastening.

Fig. 3 illustrates to be in and opens or the proposed nebulizer 1 of starting state.Therefore cover 10 rotates about 160 ° to 180 ° with respect to the transmission location of closing shown in Fig. 1.Preferably can be only in the opposite direction rotating mask 10 to open and to close cover 10.Therefore rotating retainer 36 preferably is provided, its in shown embodiment from the outside visible and (for example) outstanding from periphery or shell 13.This help to guarantee nebulizer 1 simply and operation intuitively because user understands intuitively how many covers 10 must open or close and at which side to opening or closing.Especially preferably, the rotating retainer 36 that makes of nebulizer 1 structure is formed for the retainer that is in the cover 10 of open mode and also is used to be in the cover 10 of closed condition.Perhaps, also can provide independent outthrust or retainer for this purpose.

Nebulizer 1 or cover 10 and preferably also comprise the locking device 37 shown in Fig. 4 c (being in the partial cross section of the nebulizer 1 of starting state), it guarantees only alternately to open and close cover 10.For this purpose, (for example) is axially providing at least one corresponding breech lock 38 or analog up and down or between the zone of the cover 10 of front and back configuration and shell 13 each other, and be functional to provide.

Preferably, nebulizer 1 or locking device 37 are included in the control loop 39 that illustrates separately with perspective view among Fig. 4 d.Control loop 39 its axially or planar side have tooth or breech lock 38 on both.As shown in Fig. 1, Fig. 2 and Fig. 4 c, control loop 39 is guided with rotary way in the circular passage in nebulizer 1 or its shell 37 or the analog particularly.

As indicated among Fig. 4 c, lock in shell side and to decide in the breech lock 38 that arm 40a is engaged on control loop 39, lock arm 40b is engaged in another breech lock 38 on the cover side simultaneously.Breech lock 38 matches each other with lock arm 40a and 40b so that cover 10 initially only can move in one direction or rotate with respect to shell 13, and therefore works in the opposite direction and prevent in the opposite direction rotation by locking device 37 or by lock arm 40a or 40b.

Preferably, provide a plurality of lock arm 40a on shell 13, it is engaged in the related breech lock 38 of control loop 39 and allows control loop 39 only to rotate in one direction with respect to nebulizer 1 or shell 13.Therefore, preferably also on cover 10, dispose some lock arm 40b or some lock arm 40b are associated with cover 10, and these lock arms 40b allows control loop 39 only rotating on a rotation direction with respect to cover 10.

For guaranteeing that covering 10 only alternately opens or closes fully, control loop 39 is with respect to shell 13 or cover 10 and only may rotation in one direction under any situation can alternately be blocked and if only if arrive end position out of the ordinary (that is to say, in the fully open position or fully the closed position) time and restart or release.Hereinafter will referring to according to another cross section brief explanation control loop 39 of the nebulizer 1 of Fig. 4 e with respect to shell 13 or cover this locking of 10.

Form the retainer 40c as shown in Fig. 4 d on control loop 39, it is cooperated with stopper arms 40d as shown in Fig. 4 e.Fig. 4 e illustrates the locking of control loop 39 to prevent the rotation with respect to shell 13 with example.Carry out this locking with correspondence or similar fashion between cover 10 and the control loop 39, and this is locked in and works during covering 10 reverse motions with respect to shell 13.

In above-mentioned locking, at least one retainer 40c hits at least one stopper arms 40d, make control loop 39 also be blocked with respect to the rotation of shell 13, control loop 39 may enter not in the rotation direction by lock arm 40a and 38 blocking-up of related breech lock thereof with respect to the rotation of shell 13 originally.Keep this blocking-up to move to its end position until cover 10 by stopper arms 40d.

When arriving end position, the control inclined-plane or the slidingsurface 40e that are formed on the cover 10 cause stopper arms 40d springing, make the retainer 40c of previous blocking-up now be released, and therefore cover 10 and can return with respect to control loop 39 and therefore also rotate in the opposite direction or move.Simultaneously, at this end position, another retainer 40c (not shown in Fig. 4 e) of control loop 39 blocks the relative turnability of control loop 39 with respect to cover 10 whereby in abutting connection with the stopper arms 40d that is configured on the cover 10.As a result, cover 10 now can only rotate or move until arriving other end position with control loop 39 in the opposite direction.In other end position, correspondingly block the rotation of control loop 39 once more, and to cover 10 turnability with respect to control loop 39 be freely again with respect to shell 13.Therefore, cover 10 only alternately opens or closes fully, so that guarantee simply and operation intuitively or activate and particularly so that the operation of debug.

Shown embodiment illustrates active nebulizer 1.Yet in theory, nebulizer 1 also can be configured to the passive type nebulizer.Under this situation, can save delivery apparatus 5 and/or energy storage or spring and store.Truth is, for instance, can during sucking, be absorbed into surrounding air by respiratory movement, and with this air via container 4 out of the ordinary (particularly, the access portal 30 of the insert 28 of taking in chamber 29 and using) is delivered to mouthpiece 8, makes and send or discharge and atomization preparation 2 in wanted mode.

If need, also can be independent of delivery apparatus 5 and use spring to store, for example be used for reach and/or open or close container 4, be specifically used for driving and/or activating transmitting device 23 and/or conveyer device 24.

If nebulizer 1 does not have delivery apparatus 5 and/or energy storage, then can omit actuation element 21 and needed actuating except that mobile cover 10 (that is to say the actual release of preparation 2 and the additional triggers of atomizing).More suitably, then preferably be enough to open cover 10, make next container 4 ready being directly used in suck and suck and to take place immediately with its dosage or preparation 2 so that start nebulizer 1.

Mouthpiece 8 is preferably fixture construction and/or arranged radially and/or preferably is formed directly on the shell 13.This is had the simple and compact structure of the nebulizer 1 of (particularly) level and smooth at least in fact exterior contour.Yet mouthpiece 8 also can be movably in theory, for example, collapsible, slidably, telescopically extends or can a certain other modes move.Perhaps or in addition, mouthpiece 8 also can be in different directions (for example, diagonally or axially) arranges or is configured to be used for delivery formulation 2 or aerosol.

Proposed nebulizer 1 preferably comprises an enumerator (not shown) in addition.

Proposed nebulizer 1 preferred Purely mechanical operation.

Proposed nebulizer 1 preferably only is made up of plastic assembly or part at least in essence, or only is made of plastics in essence at least.If necessary, only spring 14 and optionally grid 13 can be made of metal.

According to another feature, also can be omitted in the manual activation of effectively sending and atomizing of the preparation of carrying out by pushing actuation element 21 particularly among first embodiment 2.Truth is that the actuating of controlling by breathing preferably is provided.For instance, when in nebulizer 1, producing corresponding vacuum by breathing, can not set up inner meshing part 19 on the one hand with the spring 14 of biasing between fixing be connected or on the other hand with flexible capsule 7, another conveying or pumping element or analog between fixing be connected, so that make preparation 2 to send and particularly the atomizing of preparation 2 (that is to say, by means of being stored in energy storage or the spring energy in storing) can be during sucking takes place in fact automatically.

Some extra embodiment of proposed nebulizer 1 now will be described, wherein only emphasize to compare in essence difference or new aspect with first embodiment.Therefore explanation that provides in the preamble and note are preferably still with its original meaning application or to augment or the similar type application.

Fig. 6 and Fig. 7 illustrate the sketch map of second embodiment of proposed nebulizer 1.Fig. 6 is illustrated in container 4 and does not pierce through nebulizer in the closed position under the situation 1.It is opened or pierce through the nebulizer 1 that is in starting state under the situation that Fig. 7 is illustrated in container 4.

In a second embodiment, form contrast with first embodiment, storage 3 can not move axially.Truth is, connecting device 24 preferred axes are to slidably or removable.In shown embodiment, come fixing storage 3 by rotatable inner body 41.Connecting device 24 (its Connection Element 34 and preferably its finger piece 33 at least) is installed on the axially movable but not rotatable carriage 42.Carriage 42 is preferably axially movable by opening and/or cut out cover 10 (particularly by means of herein not the gear 15 of detailed icon) again.

Carriage 42 preferably has axial work tooth 43, the axial work tooth 43 that for example has class sawtooth slidingsurface or analog, it is with 44 cooperations of the complementation that provides on inner body 41 or form or corresponding matching tooth and be engaged on particularly and cooperate in the tooth 44 so that the axially-movable of carriage 42 cause inner body 41 and storage 3 through define, progressively further rotation.

In a second embodiment, carriage 42 cooperates along periphery with storage 3 is preferred on inner body or around inner body, and particularly with carriage 42 above the end face of the inner body 41 of the outside that centers on storage 43 extends to the other end of storage 3 and radially inwardly is back to, be formed with preferred axial tooth 43 internal edge mode and cooperate.Carriage 42 has a peripheral openings 45, and it is positioned in starting state on the extension of special container 4 that has been opened or has pierced through or the insert 28 that radially moves forward, so that sending of preparation 2 can be carried out and not get clogged at least.

In a second embodiment, use and the operation sequence identical operations program in first embodiment.

Fig. 8 with schematic cross-sectional illustrate be in open, the 3rd embodiment of the proposed nebulizer 1 of starting state.The 3rd embodiment major part is corresponding to second embodiment, but connecting device 24 and be engaged in the storage 3 not as the planar side that covers from the annular lip by inner body 41 among second embodiment but from opposite planar side and (utilize finger piece 33 and Connection Element 34 particularly).

Fig. 9 is to illustrate four embodiment of source in the proposed nebulizer 1 of transmission location or lock-out state.

Cover 10 herein and be the hat formula.The rotation axis of cover 10 disposes prejudicially or forms, and disposes particularly or is formed in the periphery or marginal area of nebulizer 1.Form contrast with previous embodiment, cover 10 only covers mouthpiece 8 in essence.

In the 4th embodiment, cover 10 open and/or close preferred not with other Function Coupling of nebulizer 1.

Nebulizer 1 has a relieving mechanism 46, and it is configured to the slide plate that can move along periphery particularly.

Figure 10 illustrates the nebulizer 1 that is in unlocked state with schematic cross-sectional.

In the 4th embodiment, nebulizer 1 has can axially movable toward each other two preferred outer enclosure parts, upper case part 47 and lower case part 48 particularly.Particularly, as shown in Figure 10, casing part 47,48 is preferably setovered away from each other by a plurality of spring elements 49, makes that in non-locking and non-compressed state upper case part 47 axially raises with respect to lower case part 48.

Two casing parts 47,48 can move axially together on the contrary with the power of spring element 49.In the axial compression state, breech locked is together particularly for two casing parts 47,48.This breech lock can discharge by activating relieving mechanism 46.

Begin from the transmission position, after release, upper case part 47 is by spring element 49 and automatic axial moves away from lower case part 48.This causes away from motion or lifter motion and the actuating of delivery apparatus 5 that is to say the increase of pump chambers 6 and the suction of surrounding air.In addition, the spring 14 that is associated with delivery apparatus 5 (its flexible capsule 7 particularly) is axially strained whereby or is compressed.Therefore spring element 21 has the spring force greater than spring 14.

In addition, above-mentioned axially-movable or lifter motion cause that the actuation element 41 that is associated with spring 14 axially raises or shifts out.

In addition, axially lifter motion causes that storage 3 moves axially and separates with connecting device 24 (not detailed icon).

Then, user (not shown) must manually axially promote two casing parts 47,48 together on the contrary with the power of spring element 49.During this axially-movable and/or during the lifter motion formerly, storage 3 is container 4 ground rotation one by one further.The further rotation of storage 3 or reach are preferably carried out by the slidably control of transmitting device 23 or analog again.Along with process continues, turned to container 4 in the delivery apparatus and then be opened and preferably be connected to conveyer device via connecting device 24 (not shown) herein again.

Figure 11 is illustrated in the starting state of nebulizer 1 of gained after the promotion together, wherein casing part 47,48 breech locks or lock together and actuation element 21 axially outstanding.Preferably, only when reaching this state or only after being opened, cover 10 just might activate actuation element 21, with permission sending and atomizing from the preparation of dosage through opening container 4.

By activating (particularly, axially be pressed into) actuation element 21, the blocking-up of retracting spring 14, make spring 14 axially to relax and activate delivery apparatus 5 whereby, make air pressurized contained in the pump chambers 6 particularly, make this air carry via attached container 4 and in wanted mode via mouthpiece 8 delivery formulations 2.

The 4th embodiment also allows very simple and direct operation.Prevent maloperation by suitable blocking-up member particularly.

Figure 12 to Figure 14 illustrates the 5th embodiment that is in corresponding to the proposed nebulizer 1 of the various states of the they's state shown in Fig. 9 to Figure 11.

The 5th embodiment and the 4th embodiment difference in essence be, container 4 or insert 28 open, pierce through and/or move and/or aligned direction with respect to the axis 12 of storage 3 or container 4 or loop configurations at least in fact axially or extend in parallel but not radially extend.In shown embodiment, mouthpiece 8 therefore dispose or be formed on storage 3 tops at nebulizer 1 or shell 13 (under this situation, the upper case part 47 particularly) side on, simultaneously mouthpiece 8 in fact with the planar side of nebulizer 1 ground or vertically outstanding or stretch out that meets at right angles.

In the 5th embodiment, begin from the transmission location shown in Figure 12, at first, cover 10 must be opened, and in shown embodiment, they preferably can be around the tangential axis that extends 12 rotations.Only be opened Shi Caike near relieving mechanism 46 when covering 10.Other aspect programs are identical with the program of the 4th embodiment.

Figure 15 illustrates the 6th embodiment of the proposed nebulizer 1 that is in transmission location with schematic cross-sectional.The 6th embodiment is similar to the 4th embodiment on the principle particularly.Yet different with previous embodiment, the 6th embodiment does not have delivery apparatus 5.More suitably, it is a passive type nebulizer 1.

In transmission location, can axially movable away from each other two casing parts 47 and 48 particularly by at least one snap fit hook 50 or analog and breech lock or lock together.After this at least one snap fit hook 50 can preferably be engaged on annular shoulder 51 or analog on another casing part 47,48, so that the chain fixing that is formed in latched position in the axial direction between two casing parts 47,48 connects.

In the 4th embodiment, preferably provide a plurality of spring elements 49.In the 6th embodiment, the only central spring element 49 that is formed by the central spiral spring particularly preferably is provided, this central authorities' spring element 49 supports two casing parts 47 and opened in 48 minutes.As shown in Figure 16, under this situation, when particularly when axial compressive force activates central relieving mechanism 46, at least one snap fit hook 50 or analog are jumped out, that is to say, do not form the breech lock of two casing parts 47 and 48, make two casing parts 47 and 48 to move axially away from each other.As the result of this lifter motion, container 4 of storage 3 preferred further rotations.Automatically take place owing to the spring force of spring element 49 away from motion or axially-movable.This axially-movable is again preferably by gear or tooth, rail plate or analog (not shown) and be converted to desired, the progressively rotational motion of storage 3.Preferably, the ball point pen mechanism of mentioning previously also can begin to work herein.Simultaneously, as the result away from motion, the Connection Element 34 of connecting device 24 can have been inclined empty container 4 separately between a comfortable last delivery period.

Then, the power with spring element 49 manually is pressed together two casing parts 47,48 on the contrary.In this way, spring element 49 is strained once more and is connected by connecting device 24 (its Connection Element 34 particularly) or open next container 4.At last, as shown in Figure 15, at least one snap fit hook 50 is automatically locking two casing parts 47 and 48 together in promoting end position together once more.

Now can suck.In the 6th embodiment, as schematically indicating by arrow 54 for the Connection Element among Figure 17 34, by breathing, user or sufferer (not shown) produce inlet 52 via Connection Element 34 and are delivered in the container 4 of opening or piercing through and with the air-flow that is passed to mouthpiece 8 from the preparation 2 of container 4 via the outlet 53 of Connection Element 34.

In the 6th embodiment, the container 4 that is using is preferably also axially opened or is pierced through.For instance, indicated in the details as shown in Figure 18 particularly, storage 3 is configured to comprise the foaming ring (not shown) of a plurality of foaming bags herein, or is configured to particularly have and is used to take in the loop bracket 55 of a plurality of preferred axes of foaming ring (not shown) or foaming bag to the dimple of opening 56.In shown embodiment, particularly, storage 3 directly forms or is fixedly attached to particularly lower case part 48 by lower case part 48.

The 6th embodiment preferably includes a blocking vessel 57, its all containers 4 be used or incline empty after further actuating of blocking-up, block further opening or the motion of casing part 47 and 48 of nebulizer 1 particularly.Blocking vessel 57 for example forms the hook on storage 3, related inner body 41 or loop bracket 55, and (for example) is engaged in the bearing 58 that forms on upper case part 47 when arriving blocking position, makes two casing parts 47 and 48 can not move axially separately again.This blocking-up preferably also is irreversible.Figure 18 illustrates casing part and is in its position that still is separated from each other.

Be similar to other embodiment, the 6th embodiment preferably includes an enumerator 59, in shown embodiment, this enumerator 59 preferably include one on storage 3 (particularly, on the outer periphery of storage 3 or lower case part 48) corresponding scale 60, and one in shell 13 the corresponding window 61 of (particularly, in upper case part 47).The relative rotation position of storage 3 is corresponding to being used or the number of still operational container 4.Therefore, scale 60 can be indicated the number of still available or the container 4 that has been used.Figure 19 illustrates enumerator 59 with the side view that excises a part.

Figure 20 illustrates the nebulizer 1 that is in unlocked state (that is to say, under upper case part 47 axial rising situations) with the view corresponding to Figure 19.In this position, storage 3 has preferably been moved axially with respect to window 61 makes that scale 60 is invisible.Truth is that preferably how a symbol (arrow or analog particularly) operates on it to illustrate to user through indication, that is to say optionally by two casing parts 47 and 48 are pressed together.On this aspect, enumerator not only is used for counting but also having the operation of another function and auxiliary proposed nebulizer 1.

As indicated among Figure 15 and Figure 16, can have central authorities or axial dimple 62 in shell 13 or upper case part 47 according to the nebulizer 1 of the 6th embodiment.This dimple 62 can be used for additional functionality or device.

Figure 21 illustrates the alternate embodiment of the nebulizer 1 that has clock 63 or have the measuring time value device.Clock 63 be preferably mounted in the dimple be incorporated into nebulizer 1 in addition or its shell 13 in.What clock 63 was constructed particularly makes that can send preferred optics, acoustics and/or vibration signal uses nebulizer 1 to remind user.

Figure 22 illustrates another alternate embodiment of the nebulizer 1 with the sealed chamber that is used for medicament or analog (not shown) or other containers.Particularly, dimple 62 structure to hold medicament or analog and can (for example) to seal by lid 64 or other closures.

Figure 23 illustrates the 8th embodiment of the proposed nebulizer 1 that is in transmission location (that is to say, close under the situation at cover 10) with schematic cross-sectional.The 8th embodiment is the passive type nebulizer 1 that is similar to the nebulizer 1 among the 7th embodiment.Yet, open and close and activate on nebulizer 1 principle corresponding to first to the 3rd embodiment by rotation or rotary cover 10.

In the 8th embodiment, storage 3 and connecting device 24 are constructed as the 7th embodiment in essence.Connecting device 24 or its Connection Element 34 are axially movable by open and close cover 10 by means of gear (not detailed icon).In transmission location, connecting device 24 or its Connection Element 34 move axially away from storage 3.

By opening cover 10 (rotation preferably reach 180 ° approximately), at first reach or further rotate storage 3, and along with axially-movable continues by connecting device 24, is pierced through or attached in addition and open next container 4 by Connection Element 34 particularly.Figure 24 illustrates this starting state with schematic cross-sectional.

When user or sufferer (not shown) are breathed when sucking, generation is via Connection Element 34 air flow by container 4 or storage chamber 31 (such as foaming bag or analog), and in this way via connect that mouthpiece 8 is discharged and delivery container 4 in contained preparation 2.

For permitting simple and cheap structure, inlet 52 and export 53 and preferably form by common elements forms by single-piece Connection Element 34 particularly.In addition, Connection Element 34 preferably also has particularly an exit passageway 65 that is adjacent to outlet 53 and broadens with funnel shaped or other suitable methods.Therefore, do not need the mouthpiece 8 on the conventional sense or be generally used for the extension or the analog of inhaler.More suitably, the correspondence with shell aperture and (if necessary) shell 13 be shaped be enough in case be formed for user or the compactness of sufferer (not shown), save spatial mouthpiece 8.

Figure 25 illustrates a sketch map, and its explanation is according to the transmitting device 23 of the nebulizer 1 of the 8th embodiment.Particularly, tooth 44 is (particularly movingly for axial tooth 43 on the storage side and the axially-displaceable on the shell side, with connecting device 24) cooperate wherein to cooperate tooth 44 to be associated with opening of cover 10 with respect to each axially-movable of tooth 43 so that reach the storage 3 desired progressively reach or the further rotation of container 4 one by one.Particularly, previously mentioned ball point pen principle begins to work once more.

Yet other structure solutions also are possible, so that by the desired progressively reach or the further rotation that storage 3 is reached in the motion (particularly, opening and/or close deutero-rotatablely moving and/or axially-movable certainly) of opening and/or closing that have concurrently of covering 10.

Form contrast with the 7th embodiment, in the 8th embodiment, enumerator 59 preferred disposition are on the planar side or axial side of nebulizer 1, and window 61 is formed on and reaches in the shell 13 in the cover 10 particularly, make preferably the current state of read-out counter all the time, even when closing when covering 10.

Also in the 8th embodiment, storage 3 also preferably possesses one and is used for the loop bracket 55 that (foaming ring or analog particularly) disposed in the fixing foaming.Yet, can use any storage 3 of wanting type herein basically, particularly even have a storage 3 of the insert 28 that is used to form container 4.

Only cover 10 so that start nebulizer 1 (that is to say, get ready), so the 8th embodiment allows especially shirtsleeve operation owing to needed for atomizing or sucking for opening.Even after atomizing or sucking, also do not need other operation bidirectionals.More suitably, only be necessary to close nebulizer 1 or cover 10.When closing cover 10 the time, connecting device 24 or its Connection Element 34 move axially away from storage 3 or the container 4 opened recently, make and recover the transmission location shown in Figure 23.

Figure 26 illustrates the schematic basic representation of height of notion of the 9th embodiment of proposed nebulizer 1.The 9th embodiment relates to and has delivery apparatus 5 and energy storage or the spring active nebulizer 1 that store of preferred disposition in the loop configurations of storage 3 or container 4, container 4 in Figure 26 only by taking in chamber 29 indications.

In the 9th embodiment, delivery apparatus 5 also preferable configuration is pump and possesses flexible capsule 7 particularly, flexible capsule 7 be used for pumping in the radial direction on delivery apparatus 5 preferably movably, extensible specifically and scalable or compressible.Spring storage or spring 14 preferably after being configured in flexible capsule 7 on this pumping direction, are configured on the side away from connecting device 24 particularly.

Figure 26 is illustrated in the spring that is in bias state under the flexible capsule 7 extension situations and stores or spring 14.Under this state, be absorbed into surrounding air by delivery apparatus 5 or flexible capsule 7.

Delivery apparatus 5 with spring storage preferably can the slide plate mode move.Next with the container 4 that uses for opening, at first radially move forward delivery apparatus 5 and connecting device 24 or Connection Element 34 make next container 4 or next insert 28 radially be pierced through or are connected and radially outward moved by delivery apparatus 5.This state is illustrated in the schematically showing among Figure 27.Then activate and take place.By making spring 14 lax in the radial direction, the flexible capsule 7 of compression, and contained air flows through Connection Element 34 and attached container 4 (particularly, attached insert 28) in the flexible capsule 7, as its result, contained preparation 2 in amount discharge container 4 or the insert 28.Then, can radially recall delivery apparatus 5 and connecting device 24 once more.In addition, spring 14 setovered once more and fastening or breech lock in offset position.

Utilize opposite radial motion, next container 4 or insert 28 can be pierced and radially outward promote particularly to open its sealing out of the ordinary.During this radial motion, spring 24 keeps compression or tension and flexible capsule 7 to keep extending.Therefore, reach the starting state of nebulizer 1.

Preferably, utilize the actuating of actuation element (not shown), spring 14 is through discharging in order to compress flexible capsule 7, that is to say in order to actuated pump, make compressed delivery media (that is to say air) be forced through insert 28 with the preparation 2 of sending or discharge or atomize or go coalescent dosage out of the ordinary and produce will spraying of preparation 2.

The part of radial motion preferably also with so that storage 3 points to or moves to next container 4, that is to say in order to activate transmitting device 23.

In the 9th embodiment, preferably particularly via pinion 66 inner engagement on storage 3, this pinion 66 preferably is engaged in the internal tooth 67 of storage 3 transmitting device 23.

Have to be noted that connecting device 24 and pump 5 are preferably formed a unit or interconnection.

Connection Element 34 is connected to slide plate and/or pump 5 and/or flexible capsule 7.

In the 9th embodiment, container 4/ is taken in chamber 29 and is formed particularly with fit form and/or rigid manner and be installed in preferred independent part on the preferred class ring carriage 55.Take in chamber 29 or container 4 preferably by sealing out of the ordinary and/or preferably separately or individually sealing (not shown in Figure 26 and Figure 27) on its exterior periphery periphery at least.

Figure 28 with similarly very schematically basic representation the tenth embodiment of proposed nebulizer 1 is shown.The tenth embodiment relates to the 9th embodiment and is similar to the 9th embodiment particularly, and configuration and/or the function aspects at delivery apparatus 5 and connecting device 24 is similar to the 9th embodiment best, and does not therefore need the explanation to these.

Figure 29 illustrates with Figure 28 with schematic cross-sectional and forms the nebulizer 1 according to the tenth embodiment that contrast has shell 13 and preferably rotatable or rotatable cover 10.

The tenth embodiment allows the rotation of (particularly) cover 10 or rotational motion to be converted to linearity and/or radial motion so that activate delivery apparatus 5 and/or connecting device 24, best so that mobile Connection Element 34.Particularly, to slide and/or gear-drivenly automatically couple or control.

In shown embodiment, nebulizer 1 has at least one control element 68, and it is constructed in dish mode (comparing with Figure 28) particularly.Control element 68 preferably is coupled to cover 10 (in shown embodiment, via as axial engagement 69 indicated among Figure 29) rotationally or for example forms by covering element 10.

Especially preferably, control element 68 forms a rail plate or some rail plates, so that wanted or the mode of necessity activates (particularly) delivery apparatus 5 and connecting device 24 or its Connection Element 34 with institute.Yet, also may use independent control element 68, rail plate and/or other gear drives to connect in theory, control and activate delivery apparatus 5 and control and activate connecting device 24 or its Connection Element 34 on the other hand with one side, and/or the different sections that are used to move.

In shown embodiment, provide first control cam or the rail plate 70 to be used for connecting device 24 or the preferred linearity or the radial motion of the slide plate 79 that forms by delivery apparatus 5 and/or connecting device 24.For this purpose, particularly, first engaged element 71 is engaged in first rail plate 70.Preferably, first engaged element 71 is rigidly connected to connecting device 24 or its Connection Element 34 directly or indirectly.

First rail plate 70 is shown in Figure 28 to be opening.Yet it also can be particularly as shown in Figure 29 dimple, groove or analog.

The path of first rail plate 70 is determined that gear drive couples or determined also can be along circumference and/or the linear movement of radially extending and the dependence of rotational motion.In shown embodiment, first rail plate 70 comprises first section 72 that extends particularly, the second preferred linear segments 73 of connection and/or second section 73 with radial component on circumference, and/or the 3rd section 74 that extends on circumference once more particularly.

Therefore, between cover 10 period of energization, that is to say, during cover 10 rotates the position shown in Figure 28 and Figure 29 (closed position or transmission location), at first during first section 72, do not have the linearity or the radial motion of connecting device 24 or slide plate 79.In shown embodiment, slide plate 79 or connecting device 24 only take place further along the linearity or the radial motion of second section 73, make Connection Element 34 contact with next container 4, be engaged on particularly in next container 4 or next insert 28, being created in delivery apparatus 5 or Connection Element 34 best is communicated with fluid between the storage chamber 31, and optionally move it by opening 30 by radially moving forward insert 28 particularly, so that open opening 30.Nebulizer 1 presents enable position.

During the starting state, delivery apparatus 5 or spring store or spring 14 preferably has been in tension at the self closing status transition.Therefore, actuation element 21 now can activated, make particularly by making lock arm 20 deflections and retracting spring 14 or flexible capsule 7 and compressor pump chamber 6 and delivery formulation 2 whereby, as its result, preparation 2 is discharged or is sent by delivery media in wanted mode and atomizing particularly, as previously explained.

In shown embodiment, cover 10 or control element 68 preferably are used for activating delivery apparatus 5 simultaneously, store or spring 14 in order to bias spring particularly.For this purpose, control element 68 comprises second control cam or the rail plate 75, second engaged element 76 and this second control cam or rail plate 75 cooperations, particularly, in shown embodiment, second control cam or the rail plate 75 and delivery apparatus 5 or spring stores or spring 14 (particularly, spring 14 radially or linear removable bearing 77) be associated, or directly or indirectly firmly be connected to delivery apparatus 5 or spring and store or spring 14.

Especially preferably, slidably or with on the delivery apparatus 5 or the mode of the slide plate on slide plate 79 guide bearing 77, slide plate 79 again with the mode of slide plate in the direction of motion (under this situation, radial direction) on slidably, and fixing or carrying connecting device 24 or its Connection Element 34 particularly.

Figure 29 illustrates the spring 14 (under this situation, compressed state) that is in offset position.Bearing 77 is by means of lock arm 20 at least and be retained on offset position.In shown embodiment, second rail plate, 75 preferable configuration so that in closed position or transmission location, spring store or spring 14 particularly by at the shoulder 78 of the radial motion of this position blocking-up second engagement 76 and fastening non-desired lax to prevent.

When actuation element 21 activated, lock arm 20 was not finished to extrinsic deflection or locking mesh, and lax spring stores or spring 14 or triggering delivery apparatus 5.Then, spring 14 is in previous described mode, in shown embodiment with linear mode or in flexible capsule 7 of compression or pump chambers 6 in the radial direction.Therefore, as explaining referring to other embodiment, the container 4 of connection or the preparation 2 (not shown in Figure 28 and Figure 29) of insert 28 of hanging oneself of then sending and atomize particularly through connecting.

Between relaxation period, second engaged element 76 moves (and optionally exceeding) towards the center of nebulizer 1 or control element 68 or towards the pivot center that covers 10 particularly.Second rail plate 75 is through correspondingly freely cutting to allow this motion.In shown embodiment, this motion is extended along the radial segment 80 of second rail plate 75 in essence.

In shown embodiment, particularly cover 10 close or travelling backwards during, control element 68 returns or spring stores or spring 14 is in tension once more.

(preferably rotate 90 ° to 180 °) when the position travelling backwards in the control element 68 self-starting states or when returning with respect to the position among Figure 28 and Figure 29, maintenance section 81 by second rail plate 75 stops bearing 77 via second engaged element 76 on a certain section of the opposite radial motion of the slide plate 79 or first engaged element 71, make in this section of motion, spring stores or spring 14 is biased once more and flexible capsule 7 extends once more, particularly till by means of lock arm 29 breech lock taking place.Between this moving period, Connection Element 34 is preferably recalled at least in part from attached container 4 or attached insert 28 simultaneously.

During further linearity or radial motion, delivery apparatus 5, connecting device 24, Connection Element 34 and slide plate 79 together with spring 14 travelling backwards of biasing to the original position shown in Figure 28 and Figure 29.

In shown embodiment, above-mentioned motion sequence is particularly by closing cover 10 and control element 68 being returned carry out with closing to be associated.

Figure 29 illustrates preferred annular storage 3 with pure schematic form again.In conjunction with this figure, can be with reference to particularly about the note of other embodiment.

During the rotation of opening motion and/or closing movement or control element 68 of cover 10, not shown transmitting device 23 preferably can activated so that make storage 3 move forward to next container 4 in the tenth embodiment.This is particularly by means of corresponding or suitable gear drive couples or analog and finishing.For instance, as explained before, can carry out moving axially of storage 3 for this purpose, carry out reach by means of preferred control cam 26 or analog on shell side in a circumferential direction or particularly.Particularly or, as using particularly gear drive to couple in other embodiments by means of screw thread.

But the individual characteristics of indivedual embodiment and aspect be combination with one another also, as required or use in other structures of nebulizer, inhaler, dispensing device or analog.

In the present invention, preferably should explain term " nebulizer " very widely so that comprise other delivery apparatus, dispensing device etc., preparation 2 or other media or fluid only need to atomize when being required and randomly can also multi-formly send simultaneously.

Hereinafter list some preferred composition and/or compositionss of preferred pharmaceutical formulation 2.As mentioning, it is in particular powder or liquid in the broad sense.Especially preferably, preparation 2 contains following each material:

Hereinafter listed chemical compound can himself or combination be used for apparatus of the present invention.In the mentioned hereinafter chemical compound, W is pharmacological active substance and is selected from (for example) following material: β analogies (betamimetics), anticholinergic, corticosteroid, PDE4-inhibitor, LTD4-antagonist, EGFR-inhibitor, dopamine agonist, H1-antihistaminic, PAF-antagonist and PI3-inhibitors of kinases.In addition, dual or three recombinations of W can and be used for apparatus of the present invention through combination.The combination of W may be (for example):

-W represents the combination of β analogies and anticholinergic agents, corticosteroid, PDE4-inhibitor, EGFR-inhibitor or LTD4-antagonist,

-W represents the combination of anticholinergic agents and β analogies, corticosteroid, PDE4-inhibitor, EGFR-inhibitor or LTD4-antagonist,

-W represents the combination of corticosteroid and PDE4-inhibitor, EGFR-inhibitor or LTD4-antagonist,

-W represents the combination of PDE4-inhibitor and EGFR-inhibitor or LTD4-antagonist,

-W represents the combination of EGFR-inhibitor and LTD4-antagonist.

Preferably, as the chemical compound of β analogies are the chemical compounds that are selected from following: albuterol, Ah's formoterol (arformoterol), bambuterol, bitolterol, broxaterol, carbuterol, clenbuterol, fenoterol, formoterol, hexoprenaline, ibuterol, neoisuprel, isoproterenol, levosalbutamol, Mabuterol, meluadrine, orciprenaline, orciprenaline, pirbuterol, procaterol, reproterol, rimiterol, ritodrine, Salmefamol, salmaterol, soterenol (soterenol), Suo Fenteluo (sulphonterol), terbutaline, tiaramide, special sieve (tolubuterol) of special infectious coryza, zinterol (zinterol), CHF-1035, HOKU-81, KUL-1248, and

3-(4-{6-[2-hydroxyl-2-(4-hydroxyl-3-hydroxymethyl-phenyl)-ethylamino]-hexyl oxygen base }-butyl)-benzyl-sulfonamide

5-[2-(5,6-diethyl-indane-2-base is amino)-1-hydroxyl-ethyl]-8-hydroxyl-1H-quinoline-2-one-

4-hydroxyl-7-[2-{[2-{[3-(2-phenyl ethoxy) propyl group] sulfonyl } ethyl]-amino } ethyl]-2 (3H)-benzothiazolones

1-(2-fluoro-4-hydroxy phenyl)-2-[4-(1-benzimidazolyl)-2-methyl-2-butyl amino] ethanol

1-[3-(4-methoxy-benzyl-amino)-4-hydroxy phenyl]-2-[4-(1-benzimidazolyl)-2-methyl-2-butyl amino] ethanol

1-[2H-5-hydroxyl-3-oxo-4H-1,4-benzoxazinyl-8-yl]-2-[3-(4-N, N-dimethylaminophenyl)-2-methyl-2-propyl group amino] ethanol

1-[2H-5-hydroxyl-3-oxo-4H-1,4-benzoxazinyl-8-yl]-2-[3-(4-methoxyphenyl)-2-methyl-2-propyl group amino] ethanol

1-[2H-5-hydroxyl-3-oxo-4H-1,4-benzoxazinyl-8-yl]-2-[3-(4-normal-butyl oxygen base phenyl)-2-methyl-2-propyl group amino] ethanol

1-[2H-5-hydroxyl-3-oxo-4H-1,4-benzoxazinyl-8-yl]-2-{4-[3-(4-methoxyphenyl)-1,2,4-triazole-3-yl]-2-methyl-2-butyl amino } ethanol

5-hydroxyl-8-(the amino butyl of 1-hydroxyl-2-isopropyl)-2H-1,4-benzoxazinyl-3-(4H)-ketone

1-(4-amino-3-chloro-5-trifluoromethyl)-2-tert-butyl group amino) ethanol

6-hydroxyl-8-{1-hydroxyl-2-[2-(4-methoxyl group-phenyl)-1,1-dimethyl-ethylamino]-ethyl }-4H-benzo [1,4] oxazine-ketone

6-hydroxyl-8-{1-hydroxyl-2-[2-(4-phenoxy group-acetic acid ethyl ester)-1,1-dimethyl-ethylamino]-ethyl }-4H-benzo [1,4] oxazine-3-ketone

6-hydroxyl-8-{1-hydroxyl-2-[2-(4-phenoxy group-acetic acid)-1,1-dimethyl-ethylamino]-ethyl }-4H-benzo [1,4] oxazine-3-ketone

8-{2-[1,1-dimethyl-2-(2,4, the 6-trimethylphenyl)-ethylamino]-1-hydroxyl-ethyl }-6-hydroxyl-4H-benzo [1,4] oxazine-3-ketone

6-hydroxyl-8-{1-hydroxyl-2-[2-(4-hydroxyl-phenyl)-1,1-dimethyl-ethylamino]-ethyl }-4H-benzo [1,4] oxazine-3-ketone

6-hydroxyl-8-{1-hydroxyl-2-[2-(4-isopropyl-phenyl)-1,1-dimethyl-ethylamino]-ethyl }-4H-benzo [1,4] oxazine-3-ketone

8-{2-[2-(4-ethyl-phenyl)-1,1-dimethyl-ethylamino]-1-hydroxyl-ethyl }-6-hydroxyl-4H-benzo [1,4] oxazine-3-ketone

8-{2-[2-(4-ethyoxyl-phenyl)-1,1-dimethyl-ethylamino]-1-hydroxyl-ethyl }-6-hydroxyl-4H-benzo [1,4] oxazine-3-ketone

4-(4-{2-[2-hydroxyl-2-(6-hydroxyl-3-oxo-3,4-dihydro-2H-benzo [1,4] oxazine-8-yl)-ethylamino]-2-methyl-propyl group }-phenoxy group)-butanoic acid

8-{2-[2-(3,4-two fluoro-phenyl)-1,1-dimethyl-ethylamino]-1-hydroxyl-ethyl }-6-hydroxyl-4H-benzo [1,4] oxazine-3-ketone

1-(4-ethyoxyl-carbonylamino-3-cyano group-5-fluorophenyl)-2-(tert-butyl group amino) ethanol

2-hydroxyl-5-(1-hydroxyl-2-{2-[4-(2-hydroxyl-2-phenyl-ethylamino)-phenyl]-ethylamino }-ethyl)-benzaldehyde

N-[2-hydroxyl-5-(1-hydroxyl-2-{2-[4-(2-hydroxyl-2-phenyl-ethylamino)-phenyl]-ethylamino }-ethyl)-phenyl]-Methanamide

8-hydroxyl-5-(1-hydroxyl-2-{2-[4-(6-methoxyl group-biphenyl-3-base is amino)-phenyl]-ethylamino }-ethyl)-the 1H-quinoline-2-one-

8-hydroxyl-5-[1-hydroxyl-2-(6-phenethyl amino-hexyl amino)-ethyl]-the 1H-quinoline-2-one-

5-[2-(2-{4-[4-(2-amino-2-methyl-propoxyl group)-phenyl amino]-phenyl }-ethylamino)-1-hydroxyl-ethyl]-8-hydroxyl-1H-quinoline-2-one-

[3-(4-{6-[2-hydroxyl-2-(4-hydroxyl-3-hydroxymethyl-phenyl)-ethylamino]-hexyl oxygen base }-butyl)-5-methyl-phenyl]-urea

4-(2-{6-[2-(2,6-two chloro-benzyloxies)-ethyoxyl]-hexyl amino }-1-hydroxyl-ethyl)-2-hydroxymethyl-phenol

3-(4-{6-[2-hydroxyl-2-(4-hydroxyl-3-hydroxymethyl-phenyl)-ethylamino]-hexyl oxygen base }-butyl)-benzsulfamide

3-(3-{7-[2-hydroxyl-2-(4-hydroxyl-3-hydroxymethyl-phenyl)-ethylamino]-heptyl oxygen base }-propyl group)-benzsulfamide

4-(2-{6-[4-(3-Pentamethylene. sulfonyl-phenyl)-butoxy]-hexyl amino }-1-hydroxyl-ethyl)-2-hydroxymethyl-phenol

N-diamantane (obsolete)-2-base-2-(3-{2-[2-hydroxyl-2-(4-hydroxyl-3-hydroxymethyl-phenyl)-ethylamino]-propyl group }-phenyl)-acetamide,

Optional form with its racemic modification, enantiomer or diastereomer or optional with the acceptable acid-addition salts of its pharmacology, solvate or hydrate forms.According to the present invention, the acid-addition salts of β analogies is preferably selected from following each salt: hydrochlorate, hydrobromate, hydriodate, sulfate, phosphate, methane sulfonates, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalates, succinate, benzoate and tosilate.

Spendable preferred anticholinergic preferably is selected from: tiotropium (Tiotropium) salt is preferably bromide salt; Oxygen holder ammonium (Oxitropium) salt is preferably bromide salt; Fluorine holder ammonium (Flutropium) salt is preferably bromide salt; Ipratropium (Ipratropium) salt is preferably bromide salt; GLYCOPYRRONIUM (Glycopyrronium) salt is preferably bromide salt; Trospium cation (Trospium) salt is preferably chloride salt, i.e. tolterodine (Tolterodin).In the salt referred to above, pharmacologically active partly is a cation.Anion can be preferably chloride ion, bromide ion, iodide ion, sulfate radical, phosphate radical, Loprazolam root, nitrate anion, maleate, acetate, citrate, fumaric acid radical, tartrate anion, oxalate, amber acid radical, benzoate anion or p-methyl benzenesulfonic acid root, simultaneously chloride ion, bromide ion thing, iodide ion, sulfate radical, Loprazolam root or the preferred counter ion counterionsl gegenions of p-methyl benzenesulfonic acid root.With regard to all salt, chloride, bromide, iodide and methane sulfonates are especially preferred.

Other preferred anticholinergic are the salt that is selected from formula AC-1,

X wherein ^-Indication has the anion of single negative charge, preferably be selected from the anion in following: fluorion, chloride ion, bromide ion, iodide ion, sulfate radical, phosphate radical, the Loprazolam root, nitrate anion, maleate, acetate, citrate, fumaric acid radical, tartrate anion, oxalate, amber acid radical, benzoate anion and p-methyl benzenesulfonic acid root, be preferably the anion that has single negative charge, especially be preferably selected from following anion: fluorion, chloride ion, bromide ion, Loprazolam root and p-methyl benzenesulfonic acid root, especially be preferably bromide ion, randomly be racemic isomer, the form of enantiomer or hydrate.The person of being even more important is those medicine combinations that contain the enantiomer of formula AC-1-en

X wherein ^-Can have implication mentioned above.Other preferred anticholinergic are the salt that is selected from formula AC-2

Wherein R represents methyl or ethyl, and X wherein ^-Can have implication mentioned above.

In substituting embodiment, the form that formula AC-2 chemical compound can also free alkali AC-2-alkali exists.

AC-2-alkali

Other concrete chemical compounds are:

2,2-diphenyl-propionic acid tropine alcohol ester Methobromide,

2,2-diphenyl-propionic acid Di(2-thienyl)glycolic acid scopine ester. Methobromide,

2-fluoro-2,2-diphenyl acetic acid Di(2-thienyl)glycolic acid scopine ester. Methobromide,

2-fluoro-2,2-diphenyl acetic acid tropine alcohol ester Methobromide,

3,3 ', 4,4 '-tetrafluoro diphenylglycollic acid tropine alcohol ester Methobromide,

3,3 ', 4,4 '-tetrafluoro diphenylglycollic acid Di(2-thienyl)glycolic acid scopine ester. Methobromide,

4,4 '-difluorodiphenyl glycolic tropine alcohol ester Methobromide,

4,4 '-difluorodiphenyl glycolic Di(2-thienyl)glycolic acid scopine ester. Methobromide,

3,3 '-difluorodiphenyl glycolic tropine alcohol ester Methobromide,

3,3 '-difluorodiphenyl glycolic Di(2-thienyl)glycolic acid scopine ester. Methobromide,

9-hydroxyl-fluorenes-9-carboxylic acid tropine alcohol ester Methobromide,

9-fluoro-fluorenes-9-carboxylic acid tropine alcohol ester Methobromide,

9-hydroxyl-fluorenes-9-carboxylic acid Di(2-thienyl)glycolic acid scopine ester. Methobromide,

9-fluoro-fluorenes-9-carboxylic acid Di(2-thienyl)glycolic acid scopine ester. Methobromide,

9-methyl-fluorenes-9-carboxylic acid tropine alcohol ester Methobromide,

9-methyl-fluorenes-9-carboxylic acid Di(2-thienyl)glycolic acid scopine ester. Methobromide,

Diphenylglycollic acid cyclopropyl hyoscyamine ester Methobromide,

2,2-diphenyl-propionic acid cyclopropyl hyoscyamine ester Methobromide,

9-hydroxyl-xanthene-9-carboxylic acid cyclopropyl hyoscyamine ester Methobromide,

9-methyl-fluorenes-9-carboxylic acid cyclopropyl hyoscyamine ester Methobromide,

9-methyl-xanthene-9-carboxylic acid cyclopropyl hyoscyamine ester Methobromide,

9-hydroxyl-fluorenes-9-carboxylic acid cyclopropyl hyoscyamine ester Methobromide,

4,4 '-difluorodiphenyl glycolic cyclopropyl hyoscyamine methyl ester Methobromide,

9-hydroxyl-xanthene-9-carboxylic acid tropine alcohol ester Methobromide,

9-hydroxyl-xanthene-9-carboxylic acid Di(2-thienyl)glycolic acid scopine ester. Methobromide,

9-methyl-xanthene-9-carboxylic acid tropine alcohol ester Methobromide,

9-methyl-xanthene-9-carboxylic acid Di(2-thienyl)glycolic acid scopine ester. Methobromide,

9-ethyl-xanthene-9-carboxylic acid tropine alcohol ester Methobromide,

9-difluoromethyl-xanthene-9-carboxylic acid tropine alcohol ester Methobromide,

9-hydroxymethyl-xanthene-9-carboxylic acid Di(2-thienyl)glycolic acid scopine ester. Methobromide.

Chemical compound mentioned above within the scope of the invention also can be used as salt and uses, and wherein except that Methobromide, these salt can use methyl-X, and wherein X can have above at X ^-Given implication.

As corticosteroid, the preferred chemical compound that is selected from following that uses:

Beclometasone, betamethasone, budesonide, butixocort, ciclesonide, deflazacort, dexamethasone, Ai Puruinuo, flunisolide, fluticasone, loteprednol, mometasone, prednisolone, prednisone, rofleponide, triamcinolone, RPR-106541, NS-126, ST-26 reach

6,9-two fluoro-17-[(2-furyl carbonyls) the oxygen base]-11-hydroxyl-16-methyl-3-oxo-androstane-1,4-diene-17-thiocarbonic acid (S)-methyl fluoride ester

6,9-two fluoro-11-hydroxyls-16-methyl-3-oxo-17-propionyloxy-androstane-1,4-diene-17-thiocarbonic acid (S)-(2-oxo-tetrahydrochysene-furan-3S-yl) ester

6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxo-17 α-(2,2,3,3-tetramethyl cyclopropyl carbonyl) oxygen base-androstane-1,4-diene-17 β-carboxylic acid cyano methyl ester

It is optional to be racemic form, as enantiomer, diastereomer, or randomly is the form of acceptable salt on the pharmacology and derivant, solvate and/or hydrate.Corticosteroid comprises any salt or derivant, hydrate or the solvate that may exist.The possible salt and the example of derivant are alkali metal salt (for example sodium salt or potassium salt), sulfonic benzo formates, phosphate, nicotimine hydrochlorate, acetate, dichloroacetate, propionate, dihydric phosphate, palmitate, pivalate or furoate.

Spendable PDE4-inhibitor preferably is selected from the chemical compound among the following material: enprofylline, theophylline, roflumilast, Ai Ruifu (cilomilast), TOEFL department special (Tofimilast), pumafentrine, Li Ruisite (Lirimilast), arofylline, if Ah Ti is agate, D4418, Bay-198004, BY343, CP-325366, D-4396 (Sch-351591), AWD-12-281 (GW-842470), NCS-613, CDP-840, D-4418, PD-168787, T-440, T-2585, V-11294A, C1-1018, CDC-801, CDC-3052, D-22888, YM-58997, Z-15370 reaches

N-(3,5-two chloro-1-oxo-pyridin-4-yls)-4-difluoro-methoxy-3-cyclo propyl methoxy Benzoylamide,

(-) right-[(4aR ^*, 10bS ^*)-9-ethyoxyl-1,2,3,4,4a, 10b-six hydrogen-8-methoxyl group-2-methyl benzo [s] [1,6] benzodiazine-6-yl]-N, N-diisopropyl Benzoylamide

(R)-(+)-1-(4-benzyl bromide)-4-[(3-cyclopentyloxy)-the 4-methoxyphenyl]-2-Pyrrolidone

3-(cyclopentyloxy-4-methoxyphenyl)-1-(4-N '-[N-2-cyano group-S-methyl-isothiourea group] benzyl)-2-Pyrrolidone

Along [4-cyano group-4-(3-cyclopentyloxy-4-methoxyphenyl) cyclohexane extraction-1-carboxylic acid]

2-carbomethoxy-4-cyano group-4-(3-cyclo propyl methoxy-4-difluoro-methoxy phenyl) hexamethylene-1-ketone

Along [4-cyano group-4-(3-cyclo propyl methoxy-4-difluoro-methoxy phenyl) hexamethylene-1-alcohol]

(R)-(+)-ethyl [4-(3-cyclopentyloxy-4-methoxyphenyl) pyrrolidine-2-subunit] acetas

(S)-(-)-ethyl [4-(3-cyclopentyloxy-4-methoxyphenyl) pyrrolidine-2-subunit] acetas

9-cyclopenta-5,6-dihydro-7-ethyl-3-(2-thienyl)-9H-pyrazolo [3,4-c]-1,2,4-triazol [4,3-a] pyridine

9-cyclopenta-5,6-dihydro-7-ethyl-3-(tert-butyl group)-9H-pyrazolo [3,4-c]-1,2,4-triazol [4,3-a] pyridine,

Optional form with its racemic modification, enantiomer or diastereomer, perhaps optional with the acceptable acid-addition salts of its pharmacology, solvate and/or hydrate forms.According to the present invention, the acid-addition salts of PDE4-inhibitor is preferably and is selected from by following each salt: hydrochlorate, hydrobromate, hydriodate, sulfate, phosphate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalates, succinate, benzoate and tosilate.

Employed LTD4-antagonist preferably is selected from the chemical compound in the following material: montelukast, pranlukast, zafirlukast, MCC-847 (ZD-3523), MN-001, MEN-91507 (LM-1507), VUF-5078, VUF-K-8707, L-733321 reach

1-(((R)-(3-(2-(6,7-two fluoro-2-quinolyls) vinyl) phenyl)-3-(2-(2-hydroxyl-2-propyl group) phenyl)-sulfenyl)-methyl-cyclopropane-acetic acid

1-(((1 (R)-3 (3-(2-(2, the 3-dichloro-thiophene is [3,2-b] pyridine-5-yl also)-(E)-vinyl) phenyl)-3-(2-(1-hydroxyl-1-methyl-ethyl) phenyl) propyl group) sulfenyl) methyl) cyclopropane-acetic acid

[2-[[2-(the 4-tert-butyl group-2-thiazolyl)-5-benzofuranyl] oxygen ylmethyl] phenyl]-acetic acid

Optional form, or optional form, solvate and/or hydrate forms with the acceptable acid-addition salts of its pharmacology with its racemic modification, enantiomer or diastereomer.Acid-addition salts according to the present invention is preferably and is selected from each salt: hydrochlorate, hydrobromate, hydriodate, sulfate, phosphate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalates, succinate, benzoate and tosilate.The salt of LTD4-antagonist or derivant can randomly form alkali metal salt (for example sodium salt or potassium salt), sulfonic benzo formates, phosphate, nicotimine hydrochlorate, acetate, propionate, dihydric phosphate, palmitate, pivalate or furoate.

Spendable EGFR-inhibitor preferably is selected from the chemical compound in the following material: Cetuximab, trastuzumab, ABX-EGF, Mab ICR-62 reach

4-[(3-chloro-4-fluorophenyl) amino]-6-{[4-(morpholine-4-yl)-1-oxo-2-butylene-1-yl] amino }-7-cyclo propyl methoxy-quinazoline

4-[(3-chloro-4-fluorophenyl) amino]-6-{[4-(N, N-diethylamino)-1-oxo-2-butylene-1-yl] amino }-7-cyclo propyl methoxy-quinazoline

4-[(3-chloro-4-fluorophenyl) amino]-6-{[4-(N, N-dimethylamino)-1-oxo-2-butylene-1-yl] amino }-7-cyclo propyl methoxy-quinazoline

4-[(R)-(1-phenyl-ethyl) amino]-6-{[4-(morpholine-4-yl)-1-oxo-2-butylene-1-yl] amino }-7-cyclopentyloxy-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-{[4-((R)-6-methyl-2-oxo-morpholine-4-yl)-1-oxo-2-butylene-1-yl] amino }-7-cyclo propyl methoxy-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-{[4-((R)-6-methyl-2-oxo-morpholine-4-yl)-1-oxo-2-butylene-1-yl] amino }-7-[(S)-(oxolane-3-yl) oxygen base]-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-{[4-((R)-2-methoxy-6-oxo-morpholine-4-yl)-1-oxo-2-butylene-1-yl] amino }-7-cyclo propyl methoxy-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-[2-((S)-6-methyl-2-oxo-morpholine-4-yl)-ethyoxyl]-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluorophenyl) amino]-6-(4-[N-(2-methoxyl group-ethyl)-N-methyl-amino]-1-oxo-2-butylene-1-yl } amino)-7-cyclo propyl methoxy-quinazoline

4-[(3-chloro-4-fluorophenyl) amino]-6-{[4-(N, N-dimethylamino)-1-oxo-2-butylene-1-yl] amino }-7-cyclopentyloxy-quinazoline

4-[(R)-(1-phenyl-ethyl) amino]-6-{[4-(N, N-is two-(2-methoxyl group-ethyl)-amino)-1-oxo-2-butylene-1-yl] amino }-7-cyclo propyl methoxy-quinazoline

4-[(R)-(1-phenyl-ethyl) amino]-6-(4-[N-(2-methoxyl group-ethyl)-N-ethyl-amino]-1-oxo-2-butylene-1-yl } amino)-7-cyclo propyl methoxy-quinazoline

4-[(R)-(1-phenyl-ethyl) amino]-6-(4-[N-(2-methoxyl group-ethyl)-N-methyl-amino]-1-oxo-2-butylene-1-yl } amino)-7-cyclo propyl methoxy-quinazoline

4-[(R)-(1-phenyl-ethyl) amino]-6-(4-[N-(tetrahydropyran-4-base)-N-methyl-amino]-1-oxo-2-butylene-1-yl } amino)-7-cyclo propyl methoxy-quinazoline

4-[(3-chloro-4-fluorophenyl) amino]-6-{[4-(N, N-dimethylamino)-1-oxo-2-butylene-1-yl] amino }-7-((R)-oxolane-3-base oxygen base)-quinazoline

4-[(3-chloro-4-fluorophenyl) amino]-6-{[4-(N, N-dimethylamino)-1-oxo-2-butylene-1-yl] amino }-7-((S)-oxolane-3-base oxygen base)-quinazoline

4-[(3-chloro-4-fluorophenyl) amino]-6-{[4-[N-(2-methoxyl group-ethyl)-N-methyl-amino]-1-oxo-2-butylene-1-yl } amino)-7-cyclopentyloxy-quinazoline

4-[(3-chloro-4-fluorophenyl) amino]-6-{[4-(N-cyclopropyl-N-methyl-amino)-1-oxo-2-butylene-1-yl] amino }-7-cyclopentyloxy-quinazoline

4-[(3-chloro-4-fluorophenyl) amino]-6-{[4-(N, N-dimethylamino)-1-oxo-2-butylene-1-yl] amino }-7-[(R)-(oxolane-2-yl) methoxyl group)-quinazoline

4-[(3-chloro-4-fluorophenyl) amino]-6-{[4-(N, N-dimethylamino)-1-oxo-2-butylene-1-yl] amino }-7-[(S)-(oxolane-2-yl) methoxyl group)-quinazoline

4-[(3-acetenyl-phenyl) amino]-6,7-pair-(2-methoxyl group-ethyoxyl)-quinazoline

4-[(3-chloro-4-fluorophenyl) amino]-7-[3-(morpholine-4-yl)-propyl group oxygen base]-6-[(vinyl-carbonyl) amino]-quinazoline

4-[(R)-(1-phenyl-ethyl) amino]-6-(4-hydroxyl-phenyl)-7H-pyrrolo-[2,3-d] pyrimidine

3-cyano group-4-[(3-chloro-4-fluorophenyl) amino]-6-{[4-(N, N-dimethylamino)-1-oxo-2-butylene-1-yl] amino }-7-ethoxy yl-quinoline

4-{[3-chloro-4-(3-fluoro-benzyloxy)-phenyl] amino }-6-(5-{[(2-methane sulfonyl-ethyl) amino] methyl }-furan-2-yl) quinazoline

4-[(R)-(1-phenyl-ethyl) amino]-6-{[4-((R)-6-methyl-2-oxo-morpholine-4-yl)-1-oxo-2-butylene-1-yl] amino }-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluorophenyl) amino]-6-{[4-(morpholine-4-yl)-1-oxo-2-butylene-1-yl] amino }-7-[(oxolane-2-yl) methoxyl group]-quinazoline

4-[(3-chloro-4-fluorophenyl) amino]-6-(4-[N, N-pair-(2-methoxyl group-ethyl)-amino]-1-oxo-2-butylene-1-yl } amino)-7-[(oxolane-2-yl) methoxyl group]-quinazoline

4-[(3-acetenyl-phenyl) amino]-6-{[4-(5,5-dimethyl-2-oxo-morpholine-4-yl)-1-oxo-2-butylene-1-yl] amino }-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-[2-(2,2-dimethyl-6-oxo-morpholine-4-yl)-ethyoxyl]-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-[2-(2,2-dimethyl-6-oxo-morpholine-4-yl)-ethyoxyl]-7-[(R)-(oxolane-2-yl) methoxyl group]-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-7-[2-(2,2-dimethyl-6-oxo-morpholine-4-yl)-ethyoxyl]-6-[(S)-(oxolane-2-yl) methoxyl group]-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-{2-[4-(2-oxo-morpholine-4-yl)-piperidines-1-yl]-ethyoxyl }-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-[1-(tert-butyl group oxygen base carbonyl)-piperidin-4-yl oxygen base]-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(anti--4-amino-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(anti--4-methane sulfonyl amino-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(tetrahydropyran-3-base oxygen base)-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(1-methyl-piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-{1-[(morpholine-4-yl) carbonyl]-piperidin-4-yl oxygen base }-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-the 6-{1-[(methoxy) carbonyl]-piperidin-4-yl oxygen base }-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(piperidines-3-base oxygen base)-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-[1-(2-acetyl-amino-ethyl)-piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(tetrahydropyran-4-base oxygen base)-7-ethyoxyl-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-((S)-oxolane-3-base oxygen base)-7-hydroxyl-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(tetrahydropyran-4-base oxygen base)-7-(2-methoxyl group-ethyoxyl)-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-{ is anti--the 4-[(dimethylamino) and sulfuryl amino]-hexamethylene-1-base oxygen base }-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-{ is anti--4-[(morpholine-4-yl) and carbonylamino]-hexamethylene-1-base oxygen base }-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-{ is anti--4-[(morpholine-4-yl) and sulfuryl amino]-hexamethylene-1-base oxygen base }-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(tetrahydropyran-4-base oxygen base)-7-(2-acetyl-amino-ethyoxyl)-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(tetrahydropyran-4-base oxygen base)-7-(2-methane sulfonyl amino-ethyoxyl)-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-{1-[(piperidines-1-yl) carbonyl]-piperidin-4-yl oxygen base }-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(1-amino carbonyl methyl-piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(suitable-the 4-{N-[(tetrahydropyran-4-base) carbonyl]-N-methyl-amino }-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(suitable-4-{N-[(morpholine-4-yl) carbonyl]-N-methyl-amino }-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(suitable-4-{N-[(morpholine-4-yl) sulfonyl]-N-methyl-amino }-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(anti--4-ethane sulfuryl amino-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(1-methane sulfonyl-piperidin-4-yl oxygen base)-7-ethyoxyl-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(1-methane sulfonyl-piperidin-4-yl oxygen base)-7-(2-methoxyl group-ethyoxyl)-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-[1-(2-methoxyl group-acetyl group)-piperidin-4-yl oxygen base]-7-(2-methoxyl group-ethyoxyl)-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(suitable-4-acetyl-amino-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

4-[(3-acetenyl-phenyl) amino]-6-[1-(tert-butyl group oxygen base carbonyl)-piperidin-4-yl oxygen base]-7-methoxyl group-quinazoline

4-[(3-acetenyl-phenyl) amino]-6-(tetrahydropyran-4-base oxygen base]-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(suitable-4-{N-[(piperidines-1-yl) carbonyl]-N-methyl-amino }-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(suitable-4-{N-[(4-methyl-piperazine-the 1-yl) carbonyl]-N-methyl-amino }-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-{ is suitable-4-[(morpholine-4-yl) and carbonylamino]-hexamethylene-1-base oxygen base }-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-{1-[2-(2-oxo-pyrrolidine-1-yl) ethyl]-piperidin-4-yl oxygen base }-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-{1-[(morpholine-4-yl) carbonyl]-piperidin-4-yl oxygen base }-7-(2-methoxyl group-ethyoxyl)-quinazoline

4-[(3-acetenyl-phenyl) amino]-6-(1-acetyl group-piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline

4-[(3-acetenyl-phenyl) amino]-6-(1-methyl-piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline

4-[(3-acetenyl-phenyl) amino]-6-(1-methane sulfonyl-piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(1-methyl-piperidin-4-yl oxygen base)-7-(2-methoxyl group-ethyoxyl) quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(1-isopropyl oxygen base carbonyl-piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(suitable-4-methylamino-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-{ is suitable-4-[N-(2-methoxyl group-acetyl group)-N-methyl-amino]-hexamethylene-1-base oxygen base }-7-methoxyl group-quinazoline

4-[(3-acetenyl-phenyl) amino]-6-(piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline

4-[(3-acetenyl-phenyl) amino]-6-[1-(2-methoxyl group-acetyl group)-piperidin-4-yl oxygen base]-7-methoxyl group-quinazoline

4-[(3-acetenyl-phenyl) amino]-6-{1-[(morpholine-4-yl) carbonyl]-piperidin-4-yl oxygen base }-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-{1-[(is suitable-2,6-dimethyl-morpholine-4-yl) carbonyl]-piperidin-4-yl oxygen base]-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-{1-[(2-methyl-morpholine-4-yl) carbonyl]-piperidin-4-yl oxygen base]-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-{1-[(S, S)-(2-oxa--5-aza-bicyclo [2.2.1] heptan-5-yl) carbonyl]-piperidin-4-yl oxygen base]-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-{1-[(N-methyl-N-2-methoxy ethyl-amino) carbonyl]-piperidin-4-yl oxygen base }-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(1-ethyl-piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-the 6-{1-[(2-methoxy ethyl) carbonyl]-piperidin-4-yl oxygen base }-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-{1-[(3-methoxy-propyl-amino) carbonyl]-piperidin-4-yl oxygen base }-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-[is suitable-4-(N-methane sulfonyl-N-methyl-amino)-hexamethylene-1-base oxygen base]-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-[is suitable-4-(N-acetyl group-N-methyl-amino)-hexamethylene-1-base oxygen base]-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(anti--4-methylamino-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-[is anti--4-(N-methane sulfonyl-N-methyl-amino)-hexamethylene-1-base oxygen base]-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(anti--4-dimethylamino-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(anti--4-{N-[(morpholine-4-yl) carbonyl]-N-methyl-amino }-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-[2-(2,2-dimethyl-6-oxo-morpholine-4-yl)-ethyoxyl]-7-[(S)-(oxolane-2-yl) methoxyl group]-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(1-methane sulfonyl-piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline

4-[(3-chloro-4-fluoro-phenyl) amino]-6-(1-cyano group-piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline,

Optional form with its racemic modification, enantiomer or diastereomer and optional with the acceptable acid-addition salts of its pharmacology, solvate or hydrate forms.According to the present invention, these acid-addition salts preferably are selected from following each salt: hydrochlorate, hydrobromate, hydriodate, sulfate, phosphate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalates, succinate, benzoate and tosilate.

Employed dopamine agonist preferably is selected from the chemical compound in the following material: (α-Dihydroergocryptine), lisuride, pergolide, pramipexole, Roxindole, ropinirole, talipexole, terguride and dimension are praised (Viozane) for bromocriptine, cabergoline, α-dihydro ergocryptine, its optional racemic form that is, be enantiomer, diastereomer, or randomly go up acceptable salt, solvate or hydrate for the pharmacology.According to the present invention, these acid-addition salts are preferably and are selected from following each salt: hydrochlorate, hydrobromate, hydriodate, sulfate, phosphate, methane sulfonates, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalates, succinate, benzoate and tosilate.

Spendable H1-antihistaminic preferably is selected from the chemical compound in the following material: epinastine, cetirizine, azelastine, fexofenadine, levocabastine, loratadine, mizolastine, can be how for fragrant (Ketotifen), emedastine, dimetindene, clemastine, bamipine, dexchlorpheniramine (Cexchlorpheniramine), pheniramine, doxylamine, chlorphenoxamine, dimenhydrinate, diphenhydramine, promethazine, ebastine, chlorine thunder ground, ground fixed (Desloratidine) and meclizine, its optional racemic form that is, as enantiomer, diastereomer, or randomly go up acceptable salt for the pharmacology, solvate or hydrate.According to the present invention, these acid-addition salts are preferably and are selected from by following each salt: hydrochlorate, hydrobromate, hydriodate, sulfate, phosphate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalates, succinate, benzoate and tosilate.

Also can use as EP 1,003 the disclosed macromole that sucks among 478 A1 or CA 2,297,174 A1.

In addition, described chemical compound can be selected from the derivant of following each material: the derivant of peptide, triptan (triptane), CGRP-antagonist, phosphodiesterase-V-inhibitor, its optional racemic modification, enantiomer, diastereomeric form of being, and optional its pharmacology goes up acceptable acid-addition salts, solvate and/or hydrate.

The example of peptide derivant is dihydroergotamine and Ergotamine.

The main element symbol description

1 atomizer

2 preparations

3 storages

4 containers

5 delivery apparatus

6 pump chambers

7 retractable sacks

8 mouthpieces

9 grids

10 covers

11 delivery sides to

12 axis

13 shells

14 springs

15 gears

16 have screw shell

17 internal threads

18 external screw threads

19 inner meshing parts

20 lock arms

21 actuation elements

22 engaged elements

23 transmitting devices

24 jockeys

25 external engagement parts

26 control cams

27 protrusions

The 27a ratchet

The 27b transfer arm

28 inserts

29 take in chamber

30 openings

31 storage chamber

32 passages

33 finger pieces

34 Connection Elements

35 send passage

36 rotating retainers

37 locking devices

38 breech locks

39 control loops

The 40a lock arm

40b lock arm (shell)

The 40c retainer

The 40d stopper arms

The 40e slidingsurface

41 inner bodies

42 carriages

43 teeth

44 cooperate tooth

45 peripheral openings

46 relieving mechanisms

47 upper case parts

48 lower case parts

49 spring elements

50 snap fit hooks

51 annular shoulders

52 inlets

53 outlets

54 arrows

55 loop brackets

56 dimples

57 blocking vessels

58 bearings

59 enumerators

60 scales

61 windows

62 dimples

63 clocks

64 lids

65 interface channels

66 pinions

67 internal tooths

68 control elements

69 axially engagements

70 first rail plates

71 first engaged elements

72 first sections

73 second sections

74 the 3rd sections

75 second rail plates

76 second engaged elements

77 bearings

78 shoulders

79 slide plates

80 radial components

81 fixing parts

Claims (30)

1. nebulizer (1) that is used to send specifically from the preparation (2) of a storage (3), this storage (3) has the container (4) of a plurality of preferred loop configurations, and each in these a plurality of containers (4) contains the said preparation (2) of a dosage,

This nebulizer (1) has one and is used to send the delivery media of said preparation (2), the delivery apparatus of air (5), an and/or energy storage specifically, and a spring stores specifically,

This nebulizer (1) has an extremity piece or mouthpiece (8), and it is used to send said preparation (2) specifically as aerosol, and

This nebulizer (1) has a usefulness hands and movably covers (10), and it is associated with this extremity piece or mouthpiece (8),

It is characterized in that,

This cover (10) is coupled to this delivery apparatus (5), so that be absorbed into this delivery media or this delivery media be under pressure by this delivery apparatus (5) by opening and/or close this cover (10), and/or

This cover (10) is coupled to this energy storage so that by opening and/or close this cover (10) produce power and storing energy in this energy storage.

2. nebulizer as claimed in claim 1 is characterized in that, and is that this nebulizer (1) is constructed so that this spring stores, a spring (14) is in tension so that storage power particularly.

3. nebulizer as claimed in claim 1 or 2 is characterized in that, this nebulizer (1) structure so that said preparation (2) can be sent and be atomized specifically by means of this delivery media through being absorbed into and/or being under pressure.

4. each described nebulizer (1) that is used to send specifically from the preparation (2) of a storage (3) in the claim as described above particularly, this storage (3) has the container (4) of a plurality of preferred loop configurations, in these a plurality of containers (4) each contains the said preparation (2) of a dosage

This nebulizer (1) has an extremity piece or mouthpiece (8), and it is used to send said preparation (2) specifically as aerosol, and

This nebulizer (1) has a cover (10), and it is associated with this extremity piece or mouthpiece (8) and is removable being used to open and/or close (10) with hands,

It is characterized in that

This nebulizer (1) comprises a driver or gear (15), its be used for from this cover (10) open and/or closing movement produces a preferred axially-movable opening next container (4), to be used for moving and/or this storage (3) that moves forward, to be used to strain spring storage, to be used to activate a delivery apparatus (5) and to be specifically used for being absorbed into air, and/or be used to activate an enumerator (59).

5. nebulizer as claimed in claim 4 is characterized in that, this driver or gear (15) have the different drive ratios that is used to drive different device on the power outlet side.

6. as claim 4 or 5 described nebulizers, it is characterized in that, this driver or gear (15) have a screw thread, and one rotatingly has a screw shell (16) particularly, and this has screw shell (16) especially preferably to have a female thread (17) and/or an external screw thread (18).

7. nebulizer as claimed in claim 6, it is characterized in that, this screw thread maybe this have screw shell (16) directly or indirectly be coupled to this cover (10) and/or with a rotation axis (12) arranged coaxial of this cover (10), or form this rotation axis (12) of this cover (10).

8. as each described nebulizer in the claim 4 to 7, it is characterized in that this driver or gear (15) are configured in the loop configurations of this storage (3) or these containers (4).

9. as each described nebulizer in the claim 4 to 8, it is characterized in that, this driver or gear (15) comprise that at least one rail plate (70,75) reaches the control element (68) of this rail plate of formation (70,75) specifically, and this control element (68) preferably can cover (10) and rotate by means of this.

10. each described nebulizer in the claim as described above is characterized in that, this nebulizer (1) structure so that activate a transmitting device (23) by opening or closing this cover (10), the result makes this storage (3) reach container (4).

11. each described nebulizer in the claim as described above, it is characterized in that, this nebulizer (1) structure so that activate a connecting device (24) by opening this cover (10), so that this next container (4) is connected to the atomizing that this delivery apparatus (5) is used for dosage out of the ordinary, and/or open this container (4), pierce through this container (4) specifically.

12. each described nebulizer in the claim as described above, it is characterized in that, can moving to (11) transverse to the delivery side of this extremity piece or mouthpiece (8) of this nebulizer (1) structure so that should cover (10), specifically slidably and/or rotatable, and/or it is characterized in that this cover (10) can be tangential on a shell (13) or mobile along a periphery of this nebulizer (1).

13. each described nebulizer in the claim is characterized in that as described above, this cover (10) extends along periphery in fact, extends along a circumferential sectors of this nebulizer (1) specifically.

14. each described nebulizer in the claim is characterized in that as described above, this delivery apparatus (5) comprises or forms a pump.

15. each described nebulizer in the claim is characterized in that as described above, this delivery apparatus (5) comprises and one is used to carry, the flexible capsule (7) of this delivery media of pumping particularly.

16. each described nebulizer in the claim is characterized in that as described above, this energy storage is associated with this delivery apparatus (5) or forms the part of this delivery apparatus (5).

17. each described nebulizer in the claim is characterized in that as described above, this energy storage or spring store around this delivery apparatus (5) or are configured or are incorporated in this delivery apparatus (5).

18. each described nebulizer in the claim is characterized in that as described above, and is that this nebulizer (1) is constructed so that this delivery media can and be under pressure so that send said preparation (2) by this energy storage or spring storage.

19. each described nebulizer in the claim is characterized in that as described above, this nebulizer (1) comprises a transmitting device (23) that is used for preferably progressively moving forward this storage (3), so as can adjoining land to incline empty these containers (4) thus this dosage out of the ordinary of atomizing.

20. nebulizer as claimed in claim 19 is characterized in that, this storage (3) has the tooth with this transmitting device (23) engagement, and these teeth are used to make this storage (3) to move or rotate, so that move forward these containers (4).

21. each described nebulizer in the claim is characterized in that as described above, this storage (3) is configured to a stiffening ring.

22. each described nebulizer in the claim is characterized in that as described above, this nebulizer (1) comprises that one is used to send that said preparation (2) is fixed as the preferred warp of aerosol specifically and/or the extremity piece or the mouthpiece (8) of radial guide.

23. each described nebulizer in the claim is characterized in that as described above, this nebulizer (1) textural be smooth, be plate-like specifically.

24. each described nebulizer in the claim is characterized in that as described above, this nebulizer (1) has an actuation element (21) that is positioned at central authorities, can axially pushes specifically, sends with one of the said preparation (2) that is used to trigger a dosage.

25. each described nebulizer (1) that is used to send specifically from the preparation (2) of a storage (3) in the claim as described above preferably, this storage (3) has the container (4) of a plurality of preferred loop configurations, in these a plurality of containers (4) each contains the said preparation (2) of a dosage

It is characterized in that

This nebulizer (1) has a cut out chamber that is used to hold medicament (62) that is independent of this storage (3).

26. each described nebulizer in the claim is characterized in that as described above, this nebulizer (1) has one and is used to specifically indicate and is joined by executing or the enumerator of operational these dosage (59) still.

27. each described nebulizer in the claim as described above, it is characterized in that, this nebulizer (1) has a clock (63), and is that this clock (63) is constructed specifically so that can send the prompting as this nebulizer of use (1) of a preferred optics, acoustics and/or vibration signal.

28. each described nebulizer in the claim is characterized in that as described above, this nebulizer (1) is configured to one and is used for the preferred portable type inhaler that medicinal aerosol is treated specifically, especially preferably is configured to a powder inhalator.

29. each described nebulizer in the claim is characterized in that as described above, this delivery apparatus (5) and/or this connecting device (24) can be linear, radially and/or similar slide plate mode move.

30. each described nebulizer in the claim is characterized in that as described above, this delivery apparatus (5) and/or this connecting device (24) can move by means of a rail plate (70,75), particularly slidably.

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