CN101439005B - Toothbrushing agent - Google Patents
Toothbrushing agent Download PDFInfo
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- CN101439005B CN101439005B CN 200810181117 CN200810181117A CN101439005B CN 101439005 B CN101439005 B CN 101439005B CN 200810181117 CN200810181117 CN 200810181117 CN 200810181117 A CN200810181117 A CN 200810181117A CN 101439005 B CN101439005 B CN 101439005B
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Abstract
The invention provides grains for dentifrice and dentifrice containing the same, wherein the dentifrice uses grains to disintegrate between teeth and interstice of teeth, and effects on removing teeth dirt and coloring are further improved. The grains for dentifrice contain ingredients (A) 40-91% of grinding powder by quality, (B) 5-35% of water-insoluble inorganic bond by quality and (C) 1-40% of water-insoluble fiber by quality. Besides, the average grain diameter of the grains for dentifrice ranges from 50 to 500 um.
Description
Technical field
The present invention relates to Toothbrushing agent with granule and the Toothbrushing agent that contains this granule.
Background technology
Known by have can be in mouth the intensity of perception degree and size and in the process of brushing teeth slowly disintegrate demonstrate the granule of the removing effect of the tooth dirt between tooth and teeth crevice and the Toothbrushing agent that cooperates this granule.As such granule, known have: make the water-insoluble dusty material that uses as the abrasiveness powder body bonding and intensity of disintegration that obtain is 0.1～10g/ granule (patent documentation 1) with inorganic bonding agent, perhaps, making the bonding and intensity of disintegration that obtain of water-insoluble dusty material with organic bonds such as oils and fats and higher fatty acids is 0.1～50g/ granule (patent documentation 2).In addition, in order to obtain the purpose of soft use sense, have and in cellulose powder, use the water-soluble substanceses such as saccharide and polysaccharide as the granule (patent documentation 3) of bonding agent.And, as the granule that does not contain bonding agent, known have: make the different particles aggregate of particle diameter more than 2 kinds and the granule (patent documentation 4) that obtains, to make the glomerate granule of calcium carbonate primary particle coagulation (patent documentation 5) with platy structure, make average primary particle diameter be granule (patent documentation 6) of being combined into of the calcium carbonate microparticle of 0.01～0.5 μ m etc.
[patent documentation 1] Unexamined Patent 1-299211 communique
[patent documentation 2] Unexamined Patent 4-243815 communique
[patent documentation 3] Unexamined Patent 11-236324 communique
The flat 10-506885 communique of [patent documentation 4] special table
[patent documentation 5] Unexamined Patent 10-59716 communique
[patent documentation 6] JP 2002-275041 communique
Summary of the invention
The invention provides a kind of Toothbrushing agent granule, described Toothbrushing agent contains following composition (A), (B) and (C) with granule, and mean diameter is 50～500 μ m,
(A) abrasiveness powder body 40～94 quality %,
(B) water-insoluble inorganic bond 5～35 quality %,
(C) water-insoluble fiber 1～40 quality %.
In addition, the present invention also provides the Toothbrushing agent that contains above-mentioned granule.
Description of drawings
Fig. 1 is the sketch map of concept of evaluation methodology of the dirt removal effect of evaluation model 1.
Fig. 2 be when the use level of comparison granule is changed each Toothbrushing agent to the sketch map of the removing effect of tooth dirt or dirt.
Fig. 3 has cooperated the Toothbrushing agent of granule of the present invention or comparison granule to the sketch map of the removing effect of tooth dirt or dirt.
Fig. 4 is the sketch map of concept of evaluation methodology of the removing effect of the tooth dirt of evaluation model 2 or dirt.
Fig. 5 is the simple sketch map of the Tooth-brushing device of use in evaluation model 2.
Fig. 6 is the result's of granule more of the present invention and the disintegrate easness that compares granule sketch map.
The specific embodiment
Even remove the purpose of effect or painted dirt removal effect in order to obtain high tooth dirt, and further increase the use level of these existing granules, also can't confirm the raising of expected degree effect.In addition, if improve the intensity of disintegration of granule for the purpose of the removing performance that improves the tooth dirt, then can produce foreign body sensation, this foreign body sensation be exactly in mouth the sensation granule similarly be foreign body.
Therefore, the invention provides Toothbrushing agent with granule and the Toothbrushing agent that contains this granule, this Toothbrushing agent granule is because good disintegrative and enter easily granule between the slit of tooth and tooth, and the removing effect of the removing effect of its tooth dirt and painted dirt has obtained further raising.
The present inventor is for the granule that satisfies these two kinds of reverse functions that the removing effect is improved and foreign body sensation is low of the removing effect of developing tooth dirt not only or painted dirt and carried out all research, the result is surprised to find that very much: cooperate abrasiveness powder body and water-insoluble inorganic bonding agent, and when further the hydrous water insoluble fibre comes particle modulator, resulting granule has good disintegrative, and, the removing effect of the tooth dirt between the slit of tooth and tooth or the removing effect of painted dirt also are significantly improved, simultaneously, this granule produces foreign body sensation hardly.
Toothbrushing agent of the present invention with granule have can perception in mouth size, also have in the process of brushing teeth the slowly intensity of disintegrate, and significantly be better than existing granule for the removing effect of the tooth dirt between the slit of tooth and tooth and the removing effect of painted dirt.In addition, because disintegrative is good, so fundamental sensation is less than foreign body sensation.Therefore, particularly the removing effect of the tooth dirt between tooth and teeth crevice and painted dirt is excellent for the tooth dirt for the Toothbrushing agent that contains this granule, and uses sense also excellent.
Toothbrushing agent of the present invention contains (A) abrasiveness powder body, (B) water-insoluble inorganic bonding agent and (C) water-insoluble fiber with granule.As (A) abrasiveness powder body, can enumerate as the normally used material of dental abrasive, for example, dicalcium phosphate, tricalcium phosphate, insoluble Polymeric sodium metaphosphate., silicon dioxide, aluminium hydroxide, magnesium phosphate, calcium carbonate, calcium pyrophosphate, zeolite, complex silicate aluminum salt, magnesium carbonate etc.Wherein, high and easily operation and polyfunctional viewpoint from cleaning effect, preferred calcium carbonate, silicon dioxide, aluminium hydroxide, zeolite, particularly preferably calcium carbonate.These abrasiveness powder body can use separately or also can make up more than 2 kinds and use.
Abrasiveness after the granule disintegrate and the viewpoint that does not injure tooth, (A) mean diameter of abrasiveness powder body is preferably 0.1～20 μ m, and more preferably 0.5～10 μ m is particularly preferably 1～10 μ m.
The content of (A) abrasiveness powder body is 40～94 quality % in the granule, still, the abrasiveness after disintegrative, granule disintegrate and do not injure the viewpoint of tooth, its content is preferably 50～85 quality %, is particularly preferably 60～85 quality %.
As (B) water-insoluble inorganic bonding agent, can enumerate, such as: silica gel, Magnesiumaluminumsilicate, synthetic aluminium silicate, calcium silicates, bentonite, Montmorillonitum, Kaolin, gel aluminum hydroxide, alumina sol (alumina sol), synthetic hydrotalcite etc.Wherein, preferred silicon compounds, wherein, and from the viewpoints such as operability spray granulation, preferred silica gel, Magnesiumaluminumsilicate, synthetic aluminium silicate, particularly preferably silica gel.These inorganic bonding agents can use separately or also can make up more than 2 kinds and use.
The content of (B) water-insoluble inorganic bonding agent in the granule is 5～35 quality %, but from the viewpoint of the balance of the intensity of granule and disintegrative, its content is preferably 10～35 quality %, particularly preferably 10～30 quality %.
As (C) water-insoluble fiber, the insoluble dietary fiber of preferred water, can enumerate, such as: cellulose, water-insoluble hemicellulose, lignin, chitin, chitosan etc., wherein, from the viewpoint of the removing of the disintegrative of granule, the removing of tooth dirt, painted dirt, particularly preferably cellulose.Cellulose except can be with paper pulp etc. as raw material through the cellulose of the refining Powdered dry product that forms, can also be that the Avicel that obtains confirming of the crystalline texture through processed etc. is through the cellulose of processed.In addition, except the aforementioned fibers element, can also enumerate plant as raw material through the refining and beet fiber that obtains, corn fiber, apple fiber etc.These consist of, contain the material of water-soluble fibre by cellulose, water-insoluble hemicellulose, lignin etc., so long as the water-insoluble dietary fiber just can use in the scope of the formation that does not affect granule of the present invention, intensity and disintegrative.
The content of (C) water-insoluble fiber is 1～40 quality % in the granule, but the viewpoint from the removing of the disintegrative of granule, the removing of tooth dirt, painted dirt, its content is 2～30 quality % more preferably, further be preferably 2～25 quality %, be particularly preferably 2～20 quality %.
In addition, in granule of the present invention, can also contain in the scope of the formation that does not affect granule of the present invention, intensity and disintegrative other composition.For example, the coloring agent such as titanium dioxide, ultramarine can also be contained in the granule of the present invention, the Toothbrushing agent aesthetic effect can be given by colored particles.The content of coloring agent in granule is that 0.01～10 quality %, particularly 0.1～5 quality % are more suitable.
There is granule from feeling the mouth, can confirms the effect sense, but fundamental sensation is less than foreign body sensation and can not injure tooth, viewpoint with tooth dirt removing power and painted dirt removal power sets out, the mean diameter of granule of the present invention is 50～500 μ m, consider especially effectively disintegrate of granule, be preferably 75～300 μ m.In the present invention, the mean diameter of granule is the value of measuring with sieve method (sound wave sieve, cylinder well Physicochemical SW-20-AT).
There is granule from feeling the mouth, can confirms the effect sense, but fundamental sensation is less than foreign body sensation and can not injure tooth, viewpoint with tooth dirt removing power sets out, the intensity of disintegration of granule of the present invention is preferably 1～20g/, more preferably 2～15g/, be particularly preferably 5～15g/.Intensity of disintegration among the present invention represents that (Shimadzu Seisakusho Ltd. MCTM-500) measures the meansigma methods that the granule of 10～20 particle diameters (180～200 μ m) obtains with the Mini compressed testing machine.And, also have same intensity under (moisture state) under the state of preferred granule of the present invention in being coupled to toothpaste.Namely, when using Toothbrushing agent, there is granule from feeling the mouth, can confirms the effect sense, but fundamental sensation is less than foreign body sensation and can not injure tooth, viewpoint with tooth dirt removing power and painted dirt removal power sets out, intensity under the preferred moisture state is 1～20g/, is particularly preferably 5～15g/.
Granule of the present invention can be made with known comminution granulation.For example, in the present invention, because preferred grain shape be spherical, can enumerate the shape that makes granules and be configured as the spray granulation that is almost proper sphere, the method ratio is easier to operate, preferably as the manufacture method of granule of the present invention.In addition, the granule (granules) of the unsetting shape made from comminution granulations such as extruding pelletization methods carries out the spheroidizing operation by the corner angle of granule partly being used such as Spheroidgranulatemachine etc., can obtain spherical particle.
The granule of the present invention that so obtains may be fitted in the various Toothbrushing agents such as paste Toothbrushing agent, powdery Toothbrushing agent, still, owing to can show the taste of granule, and so particularly preferably be coupled in the paste Toothbrushing agent.
The content of preferred granule of the present invention in Toothbrushing agent is 1～50 quality %, more preferably 3～30 quality %.In addition, in Toothbrushing agent of the present invention, granule of the present invention can become the grinding composition individually, also can with normally used Toothbrushing agent with grinding agent (for example aforementioned composition (A) abrasiveness powder body) in Toothbrushing agent substrate directly and usefulness, perhaps with other particle shape and use.
The modulation of Toothbrushing agent can be carried out according to a conventional method, and can be combined with other composition that uses in the common Toothbrushing agent.Can use such as binding agent, wetting agent, sweeting agent, antiseptic, pH adjusting agent, surfactant, spice etc.In addition, as medicinal ingredient, can use allantoin, tranexamic acid, vitamin E, vitamin C, sodium chloride, sodium fluoride, sodium monofluorophosphate, benzethonium chloride, enoxolone, hibitane, cetylpyridinium chloride, trichlorine hydroxyl phenylate (triclosan) etc.
The preferred binding agent that cooperates in Toothbrushing agent of the present invention.As binding agent, for example can enumerate: sodium alginate, sodium carboxymethyl cellulose, carrageenin, xanthan gum, sodium polyacrylate, hydroxyethyl-cellulose, hydroxypropyl cellulose, pectin, Tragacanth, arabic gum, guar gum, karaya, carob gum, gellan gum, tamarind gum, Semen Lini glue, polyvinyl alcohol, sodium chondroitin sulfate, methoxy-ethylene copolymer-maleic anhydride, the binding agent more than 2 kinds that preferably will be selected from wherein cooperates.The content of binding agent is all accounting for about 0.1～3 quality % in the Toothbrushing agent usually, about preferred 0.2～2.0 quality %.
As wetting agent, preferably use glycerol, Sorbitol, propylene glycol, xylitol, maltose alcohol (maltit), lactose (lactit), trehalose etc.
As sweeting agent, can enumerate: saccharin sodium, aspartame sugar, Talin, acesulfame potassium, stevioside (stevioside), Flos Chrysanthemi extract, p-met hoxycinnamic aldehyde, neohesperidin dihydro chalcone, perillartine (perillartine) etc.
As pH adjusting agent, can contain, such as: phosphoric acid and salt thereof (sodium phosphate, dibastic sodium phosphate etc.), citric acid and salt (sodium citrate etc.), malic acid and salt, gluconic acid and salt thereof, maleic acid and salt thereof, aspartic acid and salt thereof, succinic acid and salt thereof, glucuronic acid and salt thereof, fumaric acid and salt thereof, glutamic acid and salt thereof, adipic acid and salt thereof, hydrochloric acid, sodium hydroxide, potassium hydroxide, sodium silicate etc.Just the content of pH adjusting agent is not particularly limited as long as reach the pH of expection, its content is preferably 0.01～10 quality % in Toothbrushing agent is all, be particularly preferably about 0.1～5 quality %.As long as can realize that effect of the present invention just is not particularly limited the pH of Toothbrushing agent of the present invention, be generally about 4～10.
In addition, as foaming agent, can cooperate anion surfactant and non-ionic surface active agent.As anion surfactant; can enumerate; such as: the acyl amino hydrochlorates such as acyl glutamic acid sodium, acyl group sodium sarcosinate, the fatty acid ester salt of the alkylphosphonics such as alkyl phosphoric acid sodium, alkyl sulfate salt, higher fatty acids sulfonation monoglyceride salt, isethionic acid, N-methyl long acyl taurine sodium salt, polyoxyethylene MAP etc.The alkyl of the hydrophobic group in these anion surfactants, the carbon number of acyl group are preferably 6～18, are particularly preferably 10～14.In addition, as its salt particular certain cancers.As anion surfactant, and the viewpoint that can with cheap price buy good from foaminess, particularly preferably alkyl sulfate salt.
As non-ionic surface active agent, can enumerate: polyoxyethylene alkyl ether, polyxyethylated allyl ether, polyoxyethylene polyoxy-propylene, polyoxyethylene polyoxypropylene block copolymer, sucrose fatty acid ester, fatty acid glyceride, methyl glycol fatty acid ester, the Sorbitol fatty acid ester, the polyoxyethylene sorbitol fatty acid ester, four oleic acid polyoxyethylene sorbitol, fatty acid esters of alkyl glycosides, the polyoxyethylene sucrose fatty acid ester, the polyoxyethylene glycol fatty acid ester, alkyl polyglucoside, fatty monoethanol amide, the polyoxyethylene fatty acid single ethanol amide, the polyoxyethylene fatty acid diglycollic amide, polyoxyethylene castor oil, polyoxyethylene hardened castor oil, polyoxyethylene Cera Flava derivant etc.Wherein, particularly preferably sucrose fatty acid ester, polyoxyethylene hardened castor oil, polyglyceryl fatty acid ester, Sorbitol fatty acid ester.As the fatty acid part of the non-ionic surface active agent that contains fatty acid, can enumerate carbon number and be 6～24 saturated or unsaturated fatty acid, specifically, can enumerate: lauric acid, nutmeg acid, Palmic acid, oleic acid, stearic acid etc.
The content of surfactant in Toothbrushing agent of the present invention is preferably 0.1～5 quality %, more preferably 0.2～2 quality %.
As spice, can enumerate: Menthol (menthol), carvone, anethole (anethole), acetaminol, limonene, Oleum menthae (peppermint oil), Oleum Menthae Rotundifoliae (spearmint oil), ocimene, n-amyl alcohol, citronellol, α-terpinol, methyl salicylate, methyl acetate, geraniol acetate, eucalyptole, linalool, ethyl linalool, vanillin, thymol, Fructus Citri Limoniae oil, orange peel oil, sage oil, oil of rosemary, Oleum Cinnamomi, pimento oil, perilla oil, Oleum Caryophylli, Oleum Eucalypti etc.
The content of water can consider that dosage form etc. suitably sets, and its content is generally about 0～60 quality % in Toothbrushing agent is all, is preferably about 10～50 quality %.
Embodiment
Embodiment 1
(manufacturing of granule)
(mean diameter is 2～5 μ m with calcium carbonate; ト ヨ ホ ワ イ ト (Japan's electrochemical industry (strain)), silica gel (SNOWTEX SK; daily output chemistry (strain)), cellulose (KC FLOCKW-400G; Nippon Paper Chemicals Co.; Ltd.) and water be mixed to get water slurry, being about 200 ℃, temperature of outgoing air with sponging granulator at wind pushing temperature is to have implemented mist projection granulating under 80～90 ℃ the condition.Resulting granule has been carried out classification with the sieve of 90 μ m/500 μ m (particle diameter is 90～500 μ m).Be displayed in Table 1 the composition of granule after the spray drying.
In addition, intensity of disintegration is that (Shimadzu Seisakusho Ltd. MCTM-500) measures the meansigma methods that the granule of 10～20 particle diameters (180～200 μ m) is calculated with the Mini compressed testing machine.Its result is presented in the table 1 jointly.
Table 1
| Gradation composition (quality %) | Granule 1 | Granule 2 | Granule 3 | Compare granule 1 |
| Calcium carbonate | 75 | 70 | 60 | 80 |
| |
20 | 20 | 20 | 20 |
| Cellulose | 5 | 10 | 20 | — |
| Mean diameter (μ m) | 250 | 250 | 250 | 200 |
| Intensity of disintegration (g/) | 10 | 7 | 5 | 10 |
Embodiment 2
With the granule that obtains among the embodiment 1 and comparison granule, modulated Toothbrushing agent according to the prescription of table 2.To resulting Toothbrushing agent, estimate the effect of removing tooth dirt or dirt according to following 2 evaluation models.
Table 2
Toothbrushing agent
| Gradation composition (quality %) | The present invention's product 1 | The present invention's product 2 | Relatively product 1 |
| Granule 1 (intensity of disintegration 10g/) | 13 | 14 | — |
| Compare granule 1 (intensity of disintegration 10g/) | — | — | 12 |
| Silicon dioxide * 1 | 7 | 7 | 7 |
| Macrogol 600 | 3 | 3 | 3 |
| Sorbitol (70% aqueous solution) | 30 | 30 | 30 |
| Calcium carbonate (mean |
5 | 5 | 5 |
| Saccharin sodium | 1.5 | 1.5 | 1.5 |
| Sodium monofluorophosphate | 0.7 | 0.7 | 0.7 |
| Sodium carboxymethyl cellulose | 1.5 | 1.5 | 1.5 |
| Sodium lauryl sulphate | 1.5 | 1.5 | 1.5 |
| Spice | 1 | 1 | 1 |
| Purified Water | Surplus | Surplus | Surplus |
| Add up to | 100 | 100 | 100 |
*1：Sylopure #25(Fuji Silysia Chemical Ltd.)
Below the evaluation model 1 of tooth dirt or dirt is removed in expression.In addition, the concept map of expression operation in Fig. 1.
(method)
(1) fixes side by side 5 with binding agent (long-time curing type)
The 4mm glass tubing makes the between cog model.
(2) in the ditch of glass tubing the lipstick of colored red (AUBE Le-ジ ユ De レ シ ヤ ス, RD305 (flower king)) as tooth dirt or dirt.
(3) the coating lipstick of surplus is scrubbed cleaning (toothbrush, " spherical brush " standard size, plain edition (flower king)) with edible utensil with detergent (not containing grinding agent), until redness do not occur.
(4) at the various Toothbrushing agent 2g of lipstick coating.
(5) scrub to lipstick no longer drop (toothbrush is identical with (3)).
(6) remove Toothbrushing agent and lipstick with flushing water.
(7) the between cog model is immersed among the ethanol 100mL, with ultrasonic washing 10 minutes (lipstick that remains in model between cog section depths is dissolved out).
(8) for the alcoholic solution that in (7), obtains, under 540nm, measure absorbance (Abs).
And, will carry out having carried out after process above-mentioned (3) sample of (7) (8) processing as reference substance (initial value).The tooth dirt of evaluation model 1 or the clearance rate of dirt are from calculating with respect to absorbance (A) slip ((A0-A)/A0) * 100) of each Toothbrushing agent after the evaluation of the absorbance (A0) of reference substance.
The removing evaluation model 2 of tooth dirt or dirt is expressed as follows.In addition, Fig. 4 represents the concept map that operates.
(method)
(1) will bight place have R (radius of curvature) for the angle type aluminium block of the curved surface of 4mm with curved surface between in opposite directions mode placed side by side, make the between cog model.
(2) as tooth dirt or painted dirt model, sticking pencil hardness on the surface of the between cog model of (1) is videotapes (the material OPP that the printing-ink (material: carbon black and olefin resin) of 2H forms through silk screen printing with the thickness of 10 μ m, thickness is 25 μ m), it is made the videotapes magnetosphere.
(3) will be contained on the testing machine with the between cog model (aluminium block) of the painted dirt model that makes, use each Toothbrushing agent to carry out sweeping with Tooth-brushing device.In Fig. 5, show the concept map with the Tooth-brushing device sweeping.
(4) under the sweeping condition of load 200g, speed 120rpm, amplitude 30mm, sweeping number of times 120 times, use toothbrush (Check Standard (flower king)).
(5) evaluation region of between cog section is the zone suitable with a side of curved surface, and the 15mm width that will brush teeth with toothbrush is as its altitude range, wherein, and the borderline phase of described curved surface between center and aluminium block pair.That is, the area of evaluation region is (1/2) * π R * 15mm (R=4mm).
(6) the videotapes magnetosphere after the expansion sweeping is taken a picture with digital camera, and parsing is drawn a portrait, and draws a portrait by resolving, and calculates area (mm that exposes (bleaching) part that the interior printing-ink of evaluation region peels off the front tape of rear printing
2), with its removing area as tooth dirt or dirt.
In addition, the videotapes magnetosphere of (2) is to work as to be fitted on the flat surfaces, when under above-mentioned (4) condition, using the toothbrush sweeping, and after the printing-ink in the zone of process toothbrush sweeping peels off, the exposed portions serve of tape before the printing.
(result)
(1) at first, to cooperating the Toothbrushing agent (relatively product 1) of the comparison granule 1 (mismatching cellulose) of making among the embodiment 1 according to the prescription of table 2, the Toothbrushing agent when changing with the use level of evaluation model 1 mensuration granule is to the tooth dirt of between cog section or the clearance rate of dirt.Fig. 2 shows that the Toothbrushing agent that will cooperate 12 quality % to compare granule 1 is as 100 o'clock, according to the tooth dirt of evaluation model 1 or the relative value of dirt removal rate.As can be seen from Figure 2: in the situation of the granule of cellulose not, when in Toothbrushing agent, cooperating the granule of 12 quality %, Toothbrushing agent is to the clearance rate maximum of tooth dirt or the dirt of model, in the situation till its use level reaches 12 quality %, along with the raising tooth dirt of use level or the removing effect of dirt are improved, but when its use level being increased to 12 quality % when above, the removing effect of tooth dirt or dirt does not change.
In addition, Fig. 3 has shown the present invention's product 1 and 2 of table 2, relatively the Toothbrushing agent of product 1 is according to the tooth dirt of evaluation model 1 or the clearance rate of dirt.Although cooperate 5% cellulosic granule granule strength low, the removing effect of tooth dirt or dirt is high.In addition, in the Toothbrushing agent that the granule use level improves, this effect can be further enhanced.
(2) subsequently, the removing effect that the Toothbrushing agent that has cooperated the granule of the present invention that obtains in embodiment 1 has been compared tooth dirt or dirt.Jointly shown the composition of Toothbrushing agent in the table 3, according to the clearance rate of the tooth dirt of evaluation model 1 or dirt and according to the tooth dirt of evaluation model 2 or the removing area of dirt (for the purpose that compares easily, the prescription that again showed in the display list 2).In arbitrary evaluation model, the Toothbrushing agent that cooperates granule 1～3 of the present invention is compared with cooperating not the Toothbrushing agent of the comparison granule 1 of cellulose (relatively product 1: the tooth dirt of evaluation model 1 or the clearance rate of dirt are 43.6%), and the removing effect of tooth dirt or dirt is excellent.
Table 3
| Gradation composition (quality %) | The present invention's product 1 | The present invention's product 2 | The present invention's product 3 | The present invention's product 4 | The present invention's product 5 | The present invention's product 6 | Relatively product 1 |
| Granule 1 (intensity of disintegration 10g/) | 13 | 14 | — | — | 12 | — | — |
| Granule 2 (intensity of disintegration 7g/) | — | — | 13 | 14 | — | — | — |
| Granule 3 (intensity of disintegration 5g/) | — | — | — | — | — | 13 | — |
| Compare granule 1 (intensity of disintegration 10g/) | — | — | — | — | — | — | 12 |
| Silicon dioxide * 1 | 7 | 7 | 7 | 7 | 7 | 7 | 7 |
| Macrogol 600 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
| Sorbitol (70% aqueous solution) | 30 | 30 | 30 | 30 | 30 | 30 | 30 |
| Calcium carbonate (mean diameter 10 μ m) | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| Saccharin sodium | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 |
| Sodium monofluorophosphate | 0.7 | 0.7 | 0.7 | 0.7 | 0.7 | 0.7 | 0.7 |
| Sodium carboxymethyl cellulose | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 |
| Sodium lauryl sulphate | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 |
| Spice | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Purified Water | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus |
| Add up to | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
| The mean diameter of granule (μ m) | 250 | 250 | 250 | 250 | 250 | 250 | 200 |
| The intensity of disintegration of granule (g/) | 10 | 10 | 7 | 7 | 10 | 5 | 10 |
| The clearance rate (%) of evaluation model 1 tooth dirt or dirt | 60.4 | 67.5 | 55.0 | 61.8 | 59.5 | 47.1 | 43.6 |
| Removing area (the mm of evaluation model 2 tooth dirts or dirt 2) | 2.62 | 4.28 | 4.10 | 6.04 | 2.56 | 6.83 | 2.40 |
Embodiment 3
The result of remaining particle after making granule of the present invention and do not contain cellulosic granule disintegrate with microscopic examination, with Particle Phase ratio relatively, granule of the present invention is significantly trickle.In addition, to the disintegrative of granule, measure the disintegrate granularity with following methods.Its result obtains: the present invention's product (granule 1 and 2) get trickleer (table 4) than granule 1 disintegrate frequently.Therefore, think: when brushing teeth with the Toothbrushing agent that cooperates granule of the present invention, because granule disintegrate of the present invention becomes fine particle, these fine particles enter the between cog depths easily, thus the removing effect of the tooth dirt of raising between cog section and the removing effect of dirt.
[assay method] is to each disintegrate granulometry particle weight
To granule 1,2 and granule 1 relatively, select respectively the granule of particle diameter between 250～300 μ m.Get the granule of 3g through selecting respectively, each granule of obtaining is packed in the styrene rod bottle (25mL, AS ONE company) with about 15g stainless shot (4mm), to prepare test specimen.Each styrene rod bottle is mounted to the tablet abrasion tester (on the TFT-120 (Fushan Mountain industry (strain)), with fixed speed (75 revolutions/2 minutes and 30 seconds) revolution 200 times, get the particle of grain graininess below 250 μ m with screening, its ratio of expression in table 4.Similarly, divide and get grain graininess at the particle below the 125 μ m, below the 88 μ m, below the 53 μ m, be displayed in Table 4 its ratio.
Table 4
| Granule 1 | Granule 2 | Granule 3 | |
| Cellulose amount (quality %) | 5 | 10 | — |
| Intensity of disintegration (g/) | 10 | 7 | 10 |
| The particle weight (%) that 250 μ m are following | 67 | 79 | 46 |
| The particle weight (%) that 125 μ m are following | 23 | 26 | 10 |
| The particle weight (%) that 88 μ m are following | 12 | 12 | 4 |
| The particle weight (%) that 53 μ m are following | 5 | 4 | 1 |
Be appreciated that as follows from result shown in the table 4.Granule of the present invention compares than the easy disintegrate of granule, and, can obtain a large amount of trickle disintegrate particles.Therefore, the result that trickle disintegrate particle is many is exactly that the granule particle of disintegrate becomes and enters into easily between cog section.
And Fig. 6 has shown makes granule 1,2 and the rheological parameters' change with time of the disintegrate rate when relatively granule 1 turns round with fixed speed according to the said determination method.Specifically, shown and used the tablet abrasion tester, make granule 1,2 and relatively behind 75 times 2 minutes halfs of granule 1 revolution, revolution after 113 times 3 minutes 45 seconds, revolution be after 150 times 5 minutes and after turning round 200 times 6 minutes 40 seconds, the ratio of the particle weight that its 250 μ m separately are following is as the disintegrate rate.Fig. 6 shows that granule 1,2 is frequently than granule 1 winding number few (in early days), disintegrate rate height.Its result also show granule 1,2 through the time disintegrate easy.
Embodiment 4
Make 10 of 20 years old～40 years old healthy women with the present invention's product 1 and relatively product 1 brush teeth, estimate it by questionnaire method and use and feel.
[evaluation]
(1) for the removing effect of tooth dirt, according to " the removal sense of tooth dirt, dirt ", is divided into 5 grades and estimates, add up to its value.The present invention's product add up to 8 minutes, and relatively product add up to-2 minutes.
2: the removal sense of tooth dirt, dirt is abundant
1: the removal sense of tooth dirt, dirt is general
0: do not feel
-1: almost do not have the removal sense of tooth dirt, dirt
-2: do not have the removal sense of tooth dirt, dirt
(2) for the granular sensation in the process of brushing teeth, whether to feel that incompatible sense estimates.About the present invention's product, nobody feels incompatible sense (0 people/10 people), and about product relatively, then has 5 people/10 people to feel incompatible sense.
According to above result, the Toothbrushing agent that has obtained cooperating granule of the present invention equal excellent result aspect the removal sense of tooth dirt, dirt and granular sensation when brushing teeth.
Claims (7)
1. a Toothbrushing agent granule is characterized in that,
Contain following composition (A), (B) and (C),
(A) abrasiveness powder body 40～94 quality %,
(B) water-insoluble inorganic bond 5～35 quality %,
(C) water-insoluble fiber 2～20 quality %,
And described Toothbrushing agent is 50～500 μ m with the mean diameter of granule, and intensity of disintegration is 1～20g/,
Described Toothbrushing agent is used for being coupled to the paste Toothbrushing agent with granule.
2. Toothbrushing agent granule according to claim 1 is characterized in that,
Intensity of disintegration is 2～15g/.
3. Toothbrushing agent granule according to claim 1 is characterized in that,
Intensity of disintegration is 5～15g/.
4. Toothbrushing agent granule according to claim 1 is characterized in that,
Intensity of disintegration is 5～10g/.
5. Toothbrushing agent granule according to claim 1 is characterized in that,
Described Toothbrushing agent granule is by carrying out mist projection granulating and obtain containing composition (A), (B) and mixture (C).
6. Toothbrushing agent granule according to claim 1 is characterized in that,
Described composition (C) is the water-insoluble dietary fiber.
7. a Toothbrushing agent is characterized in that,
Contain the described granule of any one in the claim 1～6, and the content of water is 10～50 quality %.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007301994 | 2007-11-21 | ||
| JP2007-301994 | 2007-11-21 | ||
| JP2007301994 | 2007-11-21 | ||
| JP2008066932A JP5238304B2 (en) | 2007-11-21 | 2008-03-17 | Dentifrice |
| JP2008-066932 | 2008-03-17 | ||
| JP2008066932 | 2008-03-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101439005A CN101439005A (en) | 2009-05-27 |
| CN101439005B true CN101439005B (en) | 2013-01-02 |
Family
ID=40723707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200810181117 Active CN101439005B (en) | 2007-11-21 | 2008-11-21 | Toothbrushing agent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101439005B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2681077C1 (en) * | 2013-12-18 | 2019-03-04 | Као Корпорейшн | Dentifrice |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1375275A (en) * | 2001-03-14 | 2002-10-23 | 花王株式会社 | Teeth powder |
-
2008
- 2008-11-21 CN CN 200810181117 patent/CN101439005B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1375275A (en) * | 2001-03-14 | 2002-10-23 | 花王株式会社 | Teeth powder |
Non-Patent Citations (1)
| Title |
|---|
| 王建明等.新型纤维素衍生物.《分散体系理论在制剂学中的应用》.北京医科大学 中国协和医科大学,1995,(第1版),246-247页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101439005A (en) | 2009-05-27 |
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